386569
chr16:21689842:C>G
OTOA
NM_144672:p.Gln3Glu
NM_144672:c.7C>G
EXON1
Unknown significance
rs769673166
This variant is a VUS because it does not have enough information.
0.932
N
0.025;0.029
D
0.571
P
0.177234
N
0.999999
N
3.72
C
0
10402
0
0
11546
0
0
8650
0
1
6610
0.000151286
0
66630
0
0
906
0
0
16450
0
1
121194
0.00000825123
386570
chr16:21689848:C>T
OTOA
NM_144672:p.Pro5Ser
NM_144672:c.13C>T
EXON1
Likely benign
rs774328343
Pathogenicity is based on prediction data only. 1 out of 6 predictions were pathogenic.
-0.331
N
0.058;0.065
T
0.027
B
0.036466
N
0.999987
N
1.56
C
0
10402
0
0
11558
0
0
8650
0
0
6612
0
1
66682
0.0000149966
0
906
0
0
16478
0
1
121288
0.00000824484
386571
chr16:21689852:C>T
OTOA
NM_144672:p.Thr6Met
NM_144672:c.17C>T
EXON1
Likely benign
rs144912852
Pathogenicity is based on prediction data only. 1 out of 6 predictions were pathogenic.
-2.439
N
0.044;0.041
D
0.087
B
0.092515
N
1
N
-1.03
N
0
8600
0
1
4398
0.000227376
1
12998
0.0000769349
1
10402
0.0000961354
0
11564
0
0
8652
0
0
6612
0
0
66694
0
0
906
0
0
16488
0
1
121318
0.0000082428
386572
chr16:21689853:G>A
OTOA
NM_144672:p.Thr6Thr
NM_144672:c.18G>A
EXON1
Unknown significance
rs776083450
This variant is a VUS because it does not have enough information.
0
10402
0
0
11566
0
0
8652
0
0
6612
0
1
66700
0.0000149925
0
906
0
2
16492
0.000121271
3
121330
0.000024726
386573
chr16:21689858:->AC
OTOA
NM_144672:c.23_24insAC
EXON1
Unknown significance
rs751802266
This variant is a VUS because it does not have enough information.
0
10402
0
0
11570
0
0
8652
0
0
6612
0
1
66714
0.0000149894
0
906
0
0
16500
0
1
121356
0.00000824022
386574
chr16:21689859:C>T
OTOA
NM_144672:p.Tyr8Tyr
NM_144672:c.24C>T
EXON1
Unknown significance
rs775840011
This variant is a VUS because it does not have enough information.
386575
chr16:21689861:C>T
OTOA
NM_144672:p.Ser9Phe
NM_144672:c.26C>T
EXON1
Likely benign
rs148606491
Pathogenicity is based on prediction data only. 0 out of 6 predictions were pathogenic.
-0.374
N
0.409;0.524
T
0.0
B
0.771305
N
1
N
-2.98
N
0
8600
0
4
4398
0.000909504
4
12998
0.00030774
16
10402
0.00153817
0
11570
0
0
8654
0
1
6612
0.00015124
0
66716
0
0
906
0
0
16500
0
17
121360
0.000140079
386576
chr16:21689863:C>T
OTOA
NM_144672:p.Leu10Phe
NM_144672:c.28C>T
EXON1
Likely benign
rs546735877
Pathogenicity is based on prediction data only. 2 out of 6 predictions were pathogenic.
0.068
N
0.0
D
0.033
B
0.114661
N
1
N
0.973
C
0
1322
0
0
1006
0
0
694
0
0
1008
0
2
978
0.002
2
5008
0.000399361
0
10402
0
0
11572
0
0
8654
0
0
6612
0
0
66716
0
0
906
0
11
16502
0.000666586
11
121364
0.0000906364
386577
chr16:21689870:T>G
OTOA
NM_144672:p.Leu12Arg
NM_144672:c.35T>G
EXON1
Unknown significance
rs754205689
This variant is a VUS because it does not have enough information.
1.058
C
0.0
D
1.0
D
0.000782
D
0.946496
D
5.77
C
0
10402
0
0
11572
0
1
8654
0.000115554
0
6612
0
0
66722
0
0
908
0
0
16504
0
1
121374
0.000008239
386578
chr16:21689879:T>A
OTOA
NM_144672:p.Phe15Tyr
NM_144672:c.44T>A
EXON1
Benign
rs78970023
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0.139
N
0.03;0.033
D
0.779
P
0.00948
N
0.999296
P
4.67
C
95
8600
0.0110465
343
4398
0.07799
438
12998
0.0336975
8
400
0.02
40
320
0.125
17
320
0.053125
260
400
0.65
3
360
0.00833333
16
200
0.08
344
2000
0.172
127
1322
0.0961
14
1006
0.0139
107
694
0.1542
227
1008
0.2252
41
978
0.0419
516
5008
0.103035
840
10402
0.0807537
2829
11570
0.244512
2231
8646
0.258038
80
6612
0.0120992
896
66722
0.0134289
48
908
0.0528634
645
16510
0.0390672
7569
121370
0.062363
386579
chr16:21689891:G>A
OTOA
NM_144672:p.Gly19Glu
NM_144672:c.56G>A
EXON1
Unknown significance
rs765770190
This variant is a VUS because it does not have enough information.
1.045
C
0.049;0.059
D;T
0.493
P
0.750827
N
0.980632
N
3.83
C
0
10402
0
0
11572
0
1
8654
0.000115554
0
6612
0
0
66722
0
0
908
0
0
16510
0
1
121380
0.00000823859
386580
chr16:21689892:A>C
OTOA
NM_144672:p.Gly19Gly
NM_144672:c.57A>C
EXON1
Unknown significance
rs749912295
This variant is a VUS because it does not have enough information.
0
10402
0
0
11572
0
0
8654
0
0
6612
0
1
66722
0.0000149876
0
908
0
0
16510
0
1
121380
0.00000823859
386581
chr16:21689892:A>T
OTOA
NM_144672:p.Gly19Gly
NM_144672:c.57A>T
EXON1
Unknown significance
rs749912295
This variant is a VUS because it does not have enough information.
0
10402
0
0
11572
0
2
8654
0.000231107
0
6612
0
0
66722
0
0
908
0
0
16510
0
2
121380
0.0000164772
386582
chr16:21689893:G>A
OTOA
NM_144672:p.Val20Met
NM_144672:c.58G>A
EXON1
Unknown significance
rs779422476
This variant is a VUS because it does not have enough information.
1.045
C
0.038;0.041
D
0.986
D
0.288215
N
0.999997
N
3.77
C
0
10402
0
0
11572
0
0
8654
0
0
6612
0
1
66722
0.0000149876
0
908
0
0
16510
0
1
121380
0.00000823859
386583
chr16:21689893:G>C
OTOA
NM_144672:p.Val20Leu
NM_144672:c.58G>C
EXON1
Unknown significance
rs779422476
This variant is a VUS because it does not have enough information.
1.045
C
0.096;0.105
T
0.729
P
0.288215
N
0.999997
N
3.77
C
0
10402
0
0
11572
0
1
8654
0.000115554
0
6612
0
0
66722
0
0
908
0
0
16510
0
1
121380
0.00000823859
386584
chr16:21689897:C>T
OTOA
NM_144672:p.Ser21Leu
NM_144672:c.62C>T
EXON1
Unknown significance
rs754607351
This variant is a VUS because it does not have enough information.
0.932
N
0.008
D
0.531
P
0.18714
N
1
N
2.74
C
2
10402
0.000192271
0
11572
0
0
8654
0
0
6612
0
0
66720
0
0
908
0
0
16508
0
2
121376
0.0000164777
386585
chr16:21689898:G>A
OTOA
NM_144672:p.Ser21Ser
NM_144672:c.63G>A
EXON1
Unknown significance
rs780990149
This variant is a VUS because it does not have enough information.
0
10402
0
0
11568
0
0
8654
0
0
6612
0
1
66716
0.0000149889
0
908
0
0
16508
0
1
121368
0.0000082394
386586
chr16:21689905:A>G
OTOA
NM_144672:p.Thr24Ala
NM_144672:c.70A>G
EXON1
Likely benign
rs747900321
Pathogenicity is based on prediction data only. 0 out of 6 predictions were pathogenic.
0.235
N
0.683;0.711
T
0.0
B
0.280795
N
1
N
-0.851
N
0
10402
0
0
11566
0
0
8654
0
0
6612
0
0
66716
0
0
908
0
1
16506
0.000060584
1
121364
0.00000823968
386587
chr16:21689928:T>G
OTOA
NM_144672:c.91+2T>G
INTRON1
Unknown significance
This variant is a VUS because it does not have enough information.
1.058
C
1
D
4.65
C
0
400
0
0
320
0
0
320
0
0
400
0
0
360
0
0
200
0
0
2000
0
386588
chr16:21689929:A>G
OTOA
NM_144672:c.91+3A>G
INTRON1
Unknown significance
rs769730051
This variant is a VUS because it does not have enough information.
0
10398
0
0
11556
0
0
8654
0
0
6612
0
2
66662
0.0000300021
0
906
0
0
16480
0
2
121268
0.0000164924
386589
chr16:21689940:G>A
OTOA
NM_144672:c.91+14G>A
INTRON1
Unknown significance
rs777710266
This variant is a VUS because it does not have enough information.
1
10394
0.0000962094
0
11548
0
0
8654
0
0
6612
0
0
66634
0
0
906
0
0
16464
0
1
121212
0.00000825001
386590
chr16:21689950:C>T
OTOA
NM_144672:c.91+24C>T
INTRON1
Unknown significance
rs185354413
This variant is a VUS because it does not have enough information.
1
8600
0.000116279
0
4398
0
1
12998
0.0000769349
0
10392
0
0
11540
0
0
8652
0
0
6612
0
11
66590
0.00016519
0
904
0
0
16454
0
11
121144
0.000090801
386591
chr16:21689956:T>C
OTOA
NM_144672:c.91+30T>C
INTRON1
Unknown significance
rs772261529
This variant is a VUS because it does not have enough information.
0
10390
0
0
11530
0
0
8648
0
0
6612
0
1
66584
0.0000150186
0
904
0
0
16446
0
1
121114
0.00000825668
386592
chr16:21689958:G>A
OTOA
NM_144672:c.91+32G>A
INTRON1
Unknown significance
rs775409513
This variant is a VUS because it does not have enough information.
0
10384
0
0
11534
0
0
8648
0
0
6610
0
1
66562
0.0000150236
0
904
0
0
16446
0
1
121088
0.00000825846
386593
chr16:21689965:C>A
OTOA
NM_144672:c.91+39C>A
INTRON1
Unknown significance
rs761000445
This variant is a VUS because it does not have enough information.
0
10378
0
0
11516
0
0
8648
0
0
6608
0
1
66534
0.0000150299
0
904
0
0
16426
0
1
121014
0.00000826351
386594
chr16:21689970:->T
OTOA
NM_144672:c.91+44_91+45insT
INTRON1
Unknown significance
rs755401766
This variant is a VUS because it does not have enough information.
4
10370
0.000385728
0
11516
0
0
8642
0
0
6608
0
0
66510
0
0
904
0
0
16428
0
4
120978
0.0000330639
386595
chr16:21689975:G>A
OTOA
NM_144672:c.91+49G>A
INTRON1
Unknown significance
rs535438314
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
0
10358
0
0
11498
0
1
8628
0.000115902
0
6602
0
0
66386
0
0
900
0
0
16402
0
1
120774
0.00000827993
386596
chr16:21689976:G>A
OTOA
NM_144672:c.91+50G>A
INTRON1
Unknown significance
rs777138490
This variant is a VUS because it does not have enough information.
0
10362
0
0
11504
0
0
8624
0
0
6604
0
2
66376
0.0000301314
0
900
0
0
16398
0
2
120768
0.0000165607
386597
chr16:21689978:A>G
OTOA
NM_144672:c.91+52A>G
INTRON1
Unknown significance
rs762208638
This variant is a VUS because it does not have enough information.
0
10362
0
0
11504
0
0
8626
0
0
6600
0
1
66366
0.000015068
0
900
0
0
16400
0
1
120758
0.00000828102
386598
chr16:21690046:T>C
OTOA
NM_144672:c.91+120T>C
INTRON1
Unknown significance
rs556681772
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
4
978
0.0041
4
5008
0.000798722
386599
chr16:21690087:C>T
OTOA
NM_144672:c.92-149C>T
INTRON1
Unknown significance
rs576715493
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386600
chr16:21690096:CA>-
OTOA
NM_144672:c.92-140_92-139delCA
INTRON1
Unknown significance
rs542559376
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
4
1008
0.004
0
978
0
4
5008
0.000798722
386601
chr16:21690100:G>A
OTOA
NM_144672:c.92-136G>A
INTRON1
Unknown significance
rs764278603
This variant is a VUS because it does not have enough information.
386602
chr16:21690174:A>T
OTOA
NM_144672:c.92-62A>T
INTRON1
Benign
rs534194706
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0
1322
0
0
1006
0
0
694
0
0
1008
0
5
978
0.0051
5
5008
0.000998403
386603
chr16:21690178:G>A
OTOA
NM_144672:c.92-58G>A
INTRON1
Unknown significance
rs558754565
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386604
chr16:21690185:T>C
OTOA
NM_144672:c.92-51T>C
INTRON1
Unknown significance
rs765503180
This variant is a VUS because it does not have enough information.
0
10148
0
0
11564
0
0
8624
0
0
6608
0
1
66560
0.000015024
0
904
0
0
16506
0
1
120914
0.00000827034
386605
chr16:21690190:G>A
OTOA
NM_144672:c.92-46G>A
INTRON1
Unknown significance
rs751002817
This variant is a VUS because it does not have enough information.
0
10158
0
0
11566
0
0
8624
0
5
6608
0.000756659
0
66564
0
0
904
0
0
16506
0
5
120930
0.0000413462
386606
chr16:21690191:T>A
OTOA
NM_144672:c.92-45T>A
INTRON1
Unknown significance
rs369994436
This variant is a VUS because it does not have enough information.
1
8600
0.000116279
0
4398
0
1
12998
0.0000769349
0
10162
0
0
11566
0
0
8622
0
0
6608
0
1
66564
0.0000150231
0
904
0
0
16504
0
1
120930
0.00000826925
386607
chr16:21690192:C>G
OTOA
NM_144672:c.92-44C>G
INTRON1
Unknown significance
rs765965770
This variant is a VUS because it does not have enough information.
1
10170
0.0000983284
0
11566
0
0
8624
0
0
6606
0
0
66562
0
0
904
0
0
16506
0
1
120938
0.0000082687
386608
chr16:21690214:A>G
OTOA
NM_144672:c.92-22A>G
INTRON1
Unknown significance
rs750987667
This variant is a VUS because it does not have enough information.
0
10268
0
0
11568
0
0
8636
0
0
6612
0
0
66604
0
0
908
0
9
16510
0.000545124
9
121106
0.0000743151
386609
chr16:21690215:C>G
OTOA
NM_144672:c.92-21C>G
INTRON1
Unknown significance
rs754658744
This variant is a VUS because it does not have enough information.
0
10272
0
0
11568
0
0
8638
0
0
6612
0
3
66612
0.0000450369
0
908
0
0
16510
0
3
121120
0.0000247688
386610
chr16:21690216:A>C
OTOA
NM_144672:c.92-20A>C
INTRON1
Unknown significance
rs767091787
This variant is a VUS because it does not have enough information.
0
10290
0
0
11570
0
0
8640
0
0
6612
0
1
66620
0.0000150105
0
908
0
0
16510
0
1
121150
0.00000825423
386611
chr16:21690219:C>G
OTOA
NM_144672:c.92-17C>G
INTRON1
Unknown significance
rs180736579
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
2
694
0.0029
0
1008
0
0
978
0
2
5008
0.000399361
0
10300
0
1
11570
0.0000864304
0
8640
0
0
6612
0
0
66642
0
0
908
0
0
16510
0
1
121182
0.00000825205
386612
chr16:21690225:C>A
OTOA
NM_144672:c.92-11C>A
INTRON1
Benign
rs117553471
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
5
8600
0.000581395
0
4398
0
5
12998
0.000384675
0
400
0
0
320
0
1
320
0.003125
24
400
0.06
0
360
0
3
200
0.015
28
2000
0.014
0
1322
0
8
1006
0.008
1
694
0.0014
96
1008
0.0952
7
978
0.0072
112
5008
0.0223642
3
10340
0.000290135
3
11574
0.000259202
705
8648
0.0815217
384
6612
0.0580762
230
66680
0.00344931
17
908
0.0187225
110
16510
0.00666263
1452
121272
0.0119731
386613
chr16:21690225:C>T
OTOA
NM_144672:c.92-11C>T
INTRON1
Unknown significance
rs117553471
This variant is a VUS because it does not have enough information.
0
10340
0
0
11574
0
0
8648
0
0
6612
0
0
66680
0
0
908
0
5
16510
0.000302847
5
121272
0.0000412296
386614
chr16:21690235:G>T
OTOA
NM_144672:c.92-1G>T
INTRON1
Unknown significance
rs376382794
This variant is a VUS because it does not have enough information.
1.045
C
1
D
6.02
C
1
8600
0.000116279
0
4398
0
1
12998
0.0000769349
0
10366
0
0
11574
0
0
8654
0
0
6614
0
2
66714
0.0000299787
0
908
0
0
16510
0
2
121340
0.0000164826
386615
chr16:21690236:A>T
OTOA
NM_144672:p.Asp31Val
NM_144672:c.92A>T
EXON2
Unknown significance
rs766274586
This variant is a VUS because it does not have enough information.
1.194
C
0.002
D
0.997
D
0.000119
D
1
D
6.02
C
0
10368
0
0
11574
0
0
8654
0
0
6614
0
1
66720
0.000014988
0
908
0
0
16510
0
1
121348
0.00000824076
386616
chr16:21690240:G>T
OTOA
NM_144672:p.Leu32Phe
NM_144672:c.96G>T
EXON2
Unknown significance
rs372826296
This variant is a VUS because it does not have enough information.
-0.22
N
0.076;0.079
T
1.0
D
0.000011
D
0.993749
D
4.07
C
0
10380
0
0
11576
0
3
8654
0.000346661
0
6614
0
0
66726
0
0
908
0
0
16510
0
3
121368
0.0000247182
386617
chr16:21690245:C>T
OTOA
NM_144672:p.Pro34Leu
NM_144672:c.101C>T
EXON2
Unknown significance
rs747016683
This variant is a VUS because it does not have enough information.
0.932
N
0.0
D
0.999
D
0.00018
D
1
D
6.02
C
0
10382
0
0
11576
0
0
8654
0
0
6614
0
1
66730
0.0000149858
0
908
0
0
16510
0
1
121374
0.000008239
386618
chr16:21690247:T>C
OTOA
NM_144672:p.Leu35Leu
NM_144672:c.103T>C
EXON2
Unknown significance
rs769011374
This variant is a VUS because it does not have enough information.
0
10384
0
1
11576
0.0000863856
0
8654
0
0
6614
0
2
66734
0.0000299697
0
908
0
0
16510
0
3
121380
0.0000247158
386619
chr16:21690248:T>C
OTOA
NM_144672:p.Leu35Ser
NM_144672:c.104T>C
EXON2
Unknown significance
rs777048518
This variant is a VUS because it does not have enough information.
1.058
C
0.004;0.005
D
0.992
D
0.023865
N
0.576162
D
6.02
C
0
10384
0
0
11576
0
0
8654
0
0
6614
0
1
66734
0.0000149849
0
908
0
0
16510
0
1
121380
0.00000823859
386620
chr16:21690252:G>A
OTOA
NM_144672:p.Leu36Leu
NM_144672:c.108G>A
EXON2
Unknown significance
rs748373663
This variant is a VUS because it does not have enough information.
0
10388
0
0
11576
0
0
8654
0
0
6614
0
1
66736
0.0000149844
0
908
0
0
16510
0
1
121386
0.00000823818
386621
chr16:21690258:C>T
OTOA
NM_144672:p.Asn38Asn
NM_144672:c.114C>T
EXON2
Unknown significance
rs770229981
This variant is a VUS because it does not have enough information.
0
10392
0
0
11576
0
0
8654
0
0
6614
0
1
66736
0.0000149844
0
908
0
0
16510
0
1
121390
0.00000823791
386622
chr16:21690263:C>T
OTOA
NM_144672:p.Ala40Val
NM_144672:c.119C>T
EXON2
Likely benign
rs201061211
Pathogenicity is based on prediction data only. 2 out of 6 predictions were pathogenic.
0.065
N
0.136;0.16
T
0.597
P
0.002761
N
0.545585
N
6.02
C
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
0
10392
0
0
11576
0
0
8654
0
0
6614
0
0
66734
0
0
908
0
2
16510
0.000121139
2
121388
0.0000164761
386623
chr16:21690264:G>A
OTOA
NM_144672:p.Ala40Ala
NM_144672:c.120G>A
EXON2
Unknown significance
rs763543175
This variant is a VUS because it does not have enough information.
0
10392
0
0
11576
0
1
8654
0.000115554
0
6614
0
0
66734
0
0
908
0
1
16510
0.0000605694
2
121388
0.0000164761
386624
chr16:21690264:G>T
OTOA
NM_144672:p.Ala40Ala
NM_144672:c.120G>T
EXON2
Unknown significance
rs763543175
This variant is a VUS because it does not have enough information.
0
10392
0
0
11576
0
0
8654
0
0
6614
0
1
66734
0.0000149849
0
908
0
0
16510
0
1
121388
0.00000823805
386625
chr16:21690266:T>G
OTOA
NM_144672:c.120+2T>G
INTRON2
Unknown significance
rs79223811
This variant is a VUS because it does not have enough information.
1.058
C
1
D
6.02
C
386626
chr16:21690268:A>G
OTOA
NM_144672:c.120+4A>G
INTRON2
Unknown significance
rs74554742
This variant is a VUS because it does not have enough information.
386627
chr16:21690274:C>-
OTOA
NM_144672:c.120+10delC
INTRON2
Unknown significance
rs780808160
This variant is a VUS because it does not have enough information.
0
10396
0
0
11576
0
1
8654
0.000115554
0
6614
0
0
66736
0
0
908
0
0
16510
0
1
121394
0.00000823764
386628
chr16:21690274:C>G
OTOA
NM_144672:c.120+10C>G
INTRON2
Likely benign
24033266
rs200215069
Pathogenicity is based on ClinVar submissions. All submitters agree with this pathogenicity.
6
8600
0.000697674
0
4398
0
6
12998
0.000461609
0
10396
0
2
11576
0.000172771
0
8652
0
0
6614
0
51
66738
0.000764182
0
908
0
0
16510
0
53
121394
0.000436595
386629
chr16:21690293:G>A
OTOA
NM_144672:c.120+29G>A
INTRON2
Unknown significance
rs758989932
This variant is a VUS because it does not have enough information.
0
10398
0
1
11578
0.0000863707
0
8654
0
0
6614
0
0
66736
0
0
908
0
0
16510
0
1
121398
0.00000823737
386630
chr16:21690296:C>A
OTOA
NM_144672:c.120+32C>A
INTRON2
Unknown significance
rs551512393
This variant is a VUS because it does not have enough information.
0
10400
0
0
11578
0
0
8654
0
0
6614
0
0
66736
0
0
908
0
1
16510
0.0000605694
1
121400
0.00000823723
386631
chr16:21690296:C>G
OTOA
NM_144672:c.120+32C>G
INTRON2
Unknown significance
rs551512393
This variant is a VUS because it does not have enough information.
386632
chr16:21690297:C>T
OTOA
NM_144672:c.120+33C>T
INTRON2
Unknown significance
rs574312459
This variant is a VUS because it does not have enough information.
0
10400
0
0
11578
0
0
8654
0
0
6614
0
3
66736
0.0000449532
0
908
0
1
16510
0.0000605694
4
121400
0.0000329489
386633
chr16:21690302:A>G
OTOA
NM_144672:c.120+38A>G
INTRON2
Unknown significance
rs755692387
This variant is a VUS because it does not have enough information.
2
10402
0.000192271
0
11578
0
0
8654
0
0
6614
0
0
66736
0
0
908
0
0
16510
0
2
121402
0.0000164742
386634
chr16:21690304:T>C
OTOA
NM_144672:c.120+40T>C
INTRON2
Unknown significance
rs185776371
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386635
chr16:21690305:G>A
OTOA
NM_144672:c.120+41G>A
INTRON2
Unknown significance
rs765036142
This variant is a VUS because it does not have enough information.
0
10402
0
0
11578
0
0
8654
0
0
6614
0
1
66736
0.0000149844
0
908
0
0
16510
0
1
121402
0.0000082371
386636
chr16:21690307:A>G
OTOA
NM_144672:c.120+43A>G
INTRON2
Unknown significance
rs753536066
This variant is a VUS because it does not have enough information.
0
10402
0
0
11578
0
0
8654
0
0
6614
0
0
66736
0
0
908
0
2
16510
0.000121139
2
121402
0.0000164742
386637
chr16:21690312:C>A
OTOA
NM_144672:c.121-45C>A
INTRON2
Unknown significance
rs757221313
This variant is a VUS because it does not have enough information.
0
10402
0
0
11578
0
0
8654
0
2
6614
0.000302389
0
66740
0
0
908
0
0
16510
0
2
121406
0.0000164737
386638
chr16:21690314:A>G
OTOA
NM_144672:c.121-43A>G
INTRON2
Unknown significance
rs778657034
This variant is a VUS because it does not have enough information.
0
10402
0
0
11578
0
0
8654
0
0
6614
0
0
66740
0
0
908
0
1
16510
0.0000605694
1
121406
0.00000823683
386639
chr16:21690322:G>A
OTOA
NM_144672:c.121-35G>A
INTRON2
Unknown significance
rs372912040
This variant is a VUS because it does not have enough information.
0
10402
0
0
11578
0
0
8654
0
0
6614
0
0
66740
0
0
908
0
1
16510
0.0000605694
1
121406
0.00000823683
386640
chr16:21690322:G>C
OTOA
NM_144672:c.121-35G>C
INTRON2
Unknown significance
rs372912040
This variant is a VUS because it does not have enough information.
0
8600
0
1
4398
0.000227376
1
12998
0.0000769349
386641
chr16:21690329:T>C
OTOA
NM_144672:c.121-28T>C
INTRON2
Unknown significance
rs367724540
This variant is a VUS because it does not have enough information.
0
8600
0
3
4398
0.000682128
3
12998
0.000230805
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
7
10402
0.000672948
2
11578
0.000172741
0
8654
0
0
6614
0
0
66740
0
0
908
0
0
16510
0
9
121406
0.0000741314
386642
chr16:21690335:A>G
OTOA
NM_144672:c.121-22A>G
INTRON2
Unknown significance
rs781385117
This variant is a VUS because it does not have enough information.
0
10406
0
0
11578
0
0
8654
0
0
6614
0
0
66740
0
0
908
0
3
16510
0.000181708
3
121410
0.0000247097
386643
chr16:21690337:G>A
OTOA
NM_144672:c.121-20G>A
INTRON2
Benign
rs7187792
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
4
8600
0.000465116
63
4398
0.0143247
67
12998
0.00515464
0
400
0
1
320
0.003125
0
320
0
0
400
0
0
360
0
0
200
0
1
2000
0.0005
23
1322
0.0174
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
24
5008
0.00479233
185
10406
0.0177782
16
11578
0.00138193
0
8654
0
0
6614
0
7
66740
0.000104885
0
908
0
1
16510
0.0000605694
209
121410
0.00172144
386644
chr16:21690338:T>C
OTOA
NM_144672:c.121-19T>C
INTRON2
Unknown significance
rs369373625
This variant is a VUS because it does not have enough information.
0
8600
0
1
4398
0.000227376
1
12998
0.0000769349
1
10406
0.0000960984
0
11578
0
0
8654
0
0
6614
0
0
66740
0
0
908
0
0
16510
0
1
121410
0.00000823655
386645
chr16:21690350:C>T
OTOA
NM_144672:c.121-7C>T
INTRON2
Unknown significance
rs773660453
This variant is a VUS because it does not have enough information.
0
10406
0
0
11578
0
0
8654
0
0
6614
0
3
66740
0.0000449506
0
908
0
0
16510
0
3
121410
0.0000247097
386646
chr16:21690353:T>G
OTOA
NM_144672:c.121-4T>G
INTRON2
Unknown significance
rs749551809
This variant is a VUS because it does not have enough information.
0
10406
0
0
11578
0
1
8654
0.000115554
0
6614
0
0
66738
0
0
908
0
0
16510
0
1
121408
0.00000823669
386647
chr16:21690367:T>C
OTOA
NM_144672:p.Ile44Thr
NM_144672:c.131T>C
EXON3
Unknown significance
24033266
rs730882117
Pathogenicity is based on ClinVar submissions. All submitters agree with this pathogenicity.
1.058
C
0.004
D
0.996
D
0.000004
D
0.994299
D
6.02
C
0
10406
0
0
11578
0
0
8654
0
0
6614
0
6
66740
0.0000899011
0
908
0
0
16510
0
6
121410
0.0000494193
386648
chr16:21690374:A>G
OTOA
NM_144672:p.Gly46Gly
NM_144672:c.138A>G
EXON3
Unknown significance
rs530866594
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
1
10406
0.0000960984
0
11578
0
0
8654
0
0
6614
0
0
66740
0
0
908
0
0
16510
0
1
121410
0.00000823655
386649
chr16:21690375:A>G
OTOA
NM_144672:p.Ser47Gly
NM_144672:c.139A>G
EXON3
Unknown significance
rs757845701
This variant is a VUS because it does not have enough information.
1.194
C
0.072;0.085
T
0.571
P
0.015236
N
0.988392
N
2.44
C
386650
chr16:21690388:G>A
OTOA
NM_144672:c.151+1G>A
INTRON3
Pathogenic
Hearing loss, non-syndromic, autosomal recessive
04/10/2015 -- Manually curated by the MORL.
1.045
C
1
D
6.02
C
386651
chr16:21690391:A>G
OTOA
NM_144672:c.151+4A>G
INTRON3
Unknown significance
rs760032419
This variant is a VUS because it does not have enough information.
0
10406
0
0
11578
0
1
8654
0.000115554
0
6614
0
0
66740
0
0
908
0
0
16510
0
1
121410
0.00000823655
386652
chr16:21690395:G>A
OTOA
NM_144672:c.151+8G>A
INTRON3
Unknown significance
rs552163112
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
0
10406
0
0
11578
0
0
8654
0
0
6614
0
0
66736
0
0
908
0
3
16510
0.000181708
3
121406
0.0000247105
386653
chr16:21690396:->C
OTOA
NM_144672:c.151+9_151+10insC
INTRON3
Unknown significance
rs752396507
This variant is a VUS because it does not have enough information.
0
10406
0
1
11578
0.0000863707
0
8654
0
0
6614
0
1
66736
0.0000149844
0
908
0
7
16510
0.000423985
9
121406
0.0000741314
386654
chr16:21690396:C>T
OTOA
NM_144672:c.151+9C>T
INTRON3
Unknown significance
rs774931605
This variant is a VUS because it does not have enough information.
0
10406
0
0
11576
0
0
8654
0
0
6614
0
0
66736
0
0
908
0
7
16496
0.000424345
7
121390
0.0000576654
386655
chr16:21690403:G>A
OTOA
NM_144672:c.151+16G>A
INTRON3
Unknown significance
rs372055857
This variant is a VUS because it does not have enough information.
3
8600
0.000348837
0
4398
0
3
12998
0.000230805
0
10406
0
0
11578
0
0
8654
0
0
6614
0
7
66738
0.000104888
0
908
0
0
16510
0
7
121408
0.0000576568
386656
chr16:21690405:T>A
OTOA
NM_144672:c.151+18T>A
INTRON3
Unknown significance
rs375683455
This variant is a VUS because it does not have enough information.
0
8600
0
1
4398
0.000227376
1
12998
0.0000769349
1
10406
0.0000960984
0
11578
0
0
8654
0
0
6614
0
0
66738
0
0
908
0
0
16510
0
1
121408
0.00000823669
386657
chr16:21690430:T>G
OTOA
NM_144672:c.151+43T>G
INTRON3
Unknown significance
rs753679538
This variant is a VUS because it does not have enough information.
0
10406
0
0
11578
0
0
8654
0
0
6614
0
1
66738
0.000014984
0
908
0
0
16512
0
1
121410
0.00000823655
386658
chr16:21690434:A>G
OTOA
NM_144672:c.151+47A>G
INTRON3
Unknown significance
rs761568367
This variant is a VUS because it does not have enough information.
2
10406
0.000192197
1
11578
0.0000863707
0
8654
0
0
6614
0
3
66738
0.0000449519
0
908
0
0
16512
0
6
121410
0.0000494193
386659
chr16:21690476:G>A
OTOA
NM_144672:c.152-29G>A
INTRON3
Unknown significance
rs765116960
This variant is a VUS because it does not have enough information.
0
10370
0
0
11574
0
0
8654
0
0
6614
0
2
66734
0.0000299697
0
908
0
0
16512
0
2
121366
0.0000164791
386660
chr16:21690481:C>A
OTOA
NM_144672:c.152-24C>A
INTRON3
Unknown significance
rs750421991
This variant is a VUS because it does not have enough information.
0
10360
0
0
11574
0
0
8654
0
0
6614
0
1
66728
0.0000149862
0
908
0
0
16512
0
1
121350
0.00000824063
386661
chr16:21690487:A>G
OTOA
NM_144672:c.152-18A>G
INTRON3
Unknown significance
rs758384344
This variant is a VUS because it does not have enough information.
0
10344
0
6
11574
0.000518403
0
8654
0
0
6614
0
0
66732
0
1
908
0.00110132
0
16512
0
7
121338
0.0000576901
386662
chr16:21690497:C>T
OTOA
NM_144672:c.152-8C>T
INTRON3
Unknown significance
rs781448216
This variant is a VUS because it does not have enough information.
0
10294
0
0
11574
0
0
8654
0
0
6614
0
0
66730
0
0
908
0
2
16512
0.000121124
2
121286
0.0000164899
386663
chr16:21690511:T>C
OTOA
NM_144672:p.Leu53Pro
NM_144672:c.158T>C
EXON4
Unknown significance
rs752789222
This variant is a VUS because it does not have enough information.
1.058
C
0.001
D
1.0
D
0.002543
N
0.999999
D
5.99
C
0
10232
0
0
11574
0
0
8654
0
0
6614
0
1
66726
0.0000149867
0
908
0
0
16512
0
1
121220
0.00000824946
386664
chr16:21690522:C>T
OTOA
NM_144672:p.Gln57Stop
NM_144672:c.169C>T
EXON4
Unknown significance
rs756365553
This variant is a VUS because it does not have enough information.
0.932
N
0.050608
N
1
A
5.99
C
0
10172
0
0
11574
0
0
8654
0
0
6614
0
1
66712
0.0000149898
0
908
0
0
16512
0
1
121146
0.0000082545
386665
chr16:21690524:G>C
OTOA
NM_144672:p.Gln57His
NM_144672:c.171G>C
EXON4
Likely benign
Pathogenicity is based on prediction data only. 1 out of 6 predictions were pathogenic.
-0.204
N
0.321;0.366
T
0.01
B
0.050608
N
0.997407
N
2.96
C
0
400
0
1
320
0.003125
0
320
0
0
400
0
0
360
0
0
200
0
1
2000
0.0005
386666
chr16:21690526:T>C
OTOA
NM_144672:p.Phe58Ser
NM_144672:c.173T>C
EXON4
Unknown significance
rs777803753
This variant is a VUS because it does not have enough information.
1.058
C
0.001
D
0.999
D
0.000001
D
0.999062
D
5.99
C
0
10156
0
0
11574
0
0
8654
0
0
6614
0
1
66704
0.0000149916
0
908
0
0
16512
0
1
121122
0.00000825614
386667
chr16:21690541:C>G
OTOA
NM_144672:c.179+9C>G
INTRON4
Unknown significance
rs749514289
This variant is a VUS because it does not have enough information.
0
10092
0
2
11574
0.000172801
0
8654
0
0
6614
0
0
66674
0
0
906
0
0
16508
0
2
121022
0.0000165259
386668
chr16:21690542:C>G
OTOA
NM_144672:c.179+10C>G
INTRON4
Unknown significance
rs746658126
This variant is a VUS because it does not have enough information.
386669
chr16:21690559:G>A
OTOA
NM_144672:c.179+27G>A
INTRON4
Benign
rs12445216
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
761
8596
0.0885295
1632
4392
0.371585
2393
12988
0.184247
47
400
0.1175
73
320
0.228125
54
320
0.16875
299
400
0.7475
31
360
0.0861111
34
200
0.17
538
2000
0.269
582
1322
0.4402
90
1006
0.0895
157
694
0.2262
293
1008
0.2907
102
978
0.1043
1224
5008
0.244409
3904
9962
0.391889
3263
11554
0.282413
2781
8624
0.322472
465
6604
0.0704119
6180
66504
0.0929267
109
906
0.120309
1720
16504
0.104217
18422
120658
0.152679
386670
chr16:21690572:T>A
OTOA
NM_144672:c.179+40T>A
INTRON4
Unknown significance
rs528307113
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
0
9712
0
0
11504
0
1
8562
0.000116795
0
6594
0
0
66136
0
0
898
0
0
16482
0
1
119888
0.00000834112
386671
chr16:21690578:A>G
OTOA
NM_144672:c.179+46A>G
INTRON4
Unknown significance
rs746424685
This variant is a VUS because it does not have enough information.
2
9676
0.000206697
0
11484
0
0
8534
0
0
6582
0
0
66012
0
0
894
0
0
16468
0
2
119650
0.0000167154
386672
chr16:21690579:T>G
OTOA
NM_144672:c.179+47T>G
INTRON4
Unknown significance
rs772527280
This variant is a VUS because it does not have enough information.
0
9664
0
0
11468
0
0
8508
0
0
6580
0
1
65902
0.000015174
0
892
0
0
16452
0
1
119466
0.00000837058
386673
chr16:21690602:T>C
OTOA
NM_144672:c.179+70T>C
INTRON4
Unknown significance
rs546772662
This variant is a VUS because it does not have enough information.
2
1322
0.0015
0
1006
0
0
694
0
0
1008
0
0
978
0
2
5008
0.000399361
386674
chr16:21690649:T>C
OTOA
NM_144672:c.179+117T>C
INTRON4
Unknown significance
rs568210413
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386675
chr16:21690678:C>T
OTOA
NM_144672:c.179+146C>T
INTRON4
Unknown significance
rs781595937
This variant is a VUS because it does not have enough information.
386676
chr16:21690688:C>A
OTOA
NM_144672:c.179+156C>A
INTRON4
Unknown significance
rs535192299
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386677
chr16:21690689:G>A
OTOA
NM_144672:c.179+157G>A
INTRON4
Unknown significance
rs746166266
This variant is a VUS because it does not have enough information.
386678
chr16:21690725:->T
OTOA
NM_144672:c.179+193_179+194insT
INTRON4
Unknown significance
rs551238916
This variant is a VUS because it does not have enough information.
3
1322
0.0023
0
1006
0
0
694
0
0
1008
0
0
978
0
3
5008
0.000599042
386679
chr16:21690746:G>A
OTOA
NM_144672:c.179+214G>A
INTRON4
Unknown significance
rs550586914
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386680
chr16:21690753:G>A
OTOA
NM_144672:c.179+221G>A
INTRON4
Unknown significance
rs568737967
This variant is a VUS because it does not have enough information.
2
1322
0.0015
0
1006
0
0
694
0
0
1008
0
0
978
0
2
5008
0.000399361
386681
chr16:21690754:C>T
OTOA
NM_144672:c.179+222C>T
INTRON4
Unknown significance
rs539391946
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386682
chr16:21690785:C>T
OTOA
NM_144672:c.179+253C>T
INTRON4
Benign
rs12445825
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
582
1322
0.4402
90
1006
0.0895
157
694
0.2262
292
1008
0.2897
102
978
0.1043
1223
5008
0.244209
386683
chr16:21690786:T>C
OTOA
NM_144672:c.179+254T>C
INTRON4
Unknown significance
rs749831109
This variant is a VUS because it does not have enough information.
386684
chr16:21690818:G>A
OTOA
NM_144672:c.179+286G>A
INTRON4
Unknown significance
rs577081113
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386685
chr16:21690846:C>T
OTOA
NM_144672:c.179+314C>T
INTRON4
Unknown significance
rs545958408
This variant is a VUS because it does not have enough information.
386686
chr16:21690892:A>G
OTOA
NM_144672:c.179+360A>G
INTRON4
Unknown significance
rs190147269
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386688
chr16:21690917:G>A
OTOA
NM_144672:c.179+385G>A
INTRON4
Unknown significance
rs546404275
This variant is a VUS because it does not have enough information.
386687
chr16:21690917:G>T
OTOA
NM_144672:c.179+385G>T
INTRON4
Unknown significance
rs546404275
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386689
chr16:21690930:T>G
OTOA
NM_144672:c.179+398T>G
INTRON4
Unknown significance
rs564243363
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386690
chr16:21690972:G>A
OTOA
NM_144672:c.179+440G>A
INTRON4
Unknown significance
rs541940587
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386691
chr16:21690991:G>A
OTOA
NM_144672:c.179+459G>A
INTRON4
Unknown significance
rs528319303
This variant is a VUS because it does not have enough information.
386693
chr16:21691001:C>G
OTOA
NM_144672:c.179+469C>G
INTRON4
Unknown significance
rs148701084
This variant is a VUS because it does not have enough information.
386692
chr16:21691001:C>T
OTOA
NM_144672:c.179+469C>T
INTRON4
Benign
rs148701084
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
2
1322
0.0015
10
1006
0.0099
9
694
0.013
0
1008
0
0
978
0
21
5008
0.00419329
386694
chr16:21691016:G>A
OTOA
NM_144672:c.179+484G>A
INTRON4
Unknown significance
rs199526273
This variant is a VUS because it does not have enough information.
386695
chr16:21691021:C>T
OTOA
NM_144672:c.179+489C>T
INTRON4
Unknown significance
rs575568112
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386696
chr16:21691042:T>C
OTOA
NM_144672:c.179+510T>C
INTRON4
Benign
rs28449428
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
154
1322
0.1165
0
1006
0
5
694
0.0072
0
1008
0
1
978
0.001
160
5008
0.0319489
386697
chr16:21691077:C>T
OTOA
NM_144672:c.179+545C>T
INTRON4
Benign
rs28711934
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
582
1322
0.4402
98
1006
0.0974
156
694
0.2248
389
1008
0.3859
109
978
0.1115
1334
5008
0.266374
386698
chr16:21691078:G>T
OTOA
NM_144672:c.179+546G>T
INTRON4
Unknown significance
rs528394782
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
2
5008
0.000399361
386699
chr16:21691081:T>C
OTOA
NM_144672:c.179+549T>C
INTRON4
Unknown significance
rs546858568
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386700
chr16:21691127:C>A
OTOA
NM_144672:c.179+595C>A
INTRON4
Unknown significance
rs561719603
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386701
chr16:21691148:A>T
OTOA
NM_144672:c.179+616A>T
INTRON4
Benign
rs117866053
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
1
1322
0.0008
11
1006
0.0109
2
694
0.0029
0
1008
0
9
978
0.0092
23
5008
0.00459265
386702
chr16:21691151:A>G
OTOA
NM_144672:c.179+619A>G
INTRON4
Unknown significance
rs201764275
This variant is a VUS because it does not have enough information.
386703
chr16:21691208:C>A
OTOA
NM_144672:c.179+676C>A
INTRON4
Unknown significance
rs371402861
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386704
chr16:21691231:T>C
OTOA
NM_144672:c.179+699T>C
INTRON4
Unknown significance
rs568899522
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386705
chr16:21691290:G>A
OTOA
NM_144672:c.179+758G>A
INTRON4
Unknown significance
rs766908866
This variant is a VUS because it does not have enough information.
386706
chr16:21691293:C>G
OTOA
NM_144672:c.179+761C>G
INTRON4
Unknown significance
rs532799486
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386707
chr16:21691295:A>G
OTOA
NM_144672:c.179+763A>G
INTRON4
Unknown significance
rs550914740
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386708
chr16:21691309:C>T
OTOA
NM_144672:c.179+777C>T
INTRON4
Unknown significance
rs570854613
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386709
chr16:21691337:G>C
OTOA
NM_144672:c.179+805G>C
INTRON4
Unknown significance
rs534975950
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386710
chr16:21691352:C>T
OTOA
NM_144672:c.179+820C>T
INTRON4
Unknown significance
rs372679215
This variant is a VUS because it does not have enough information.
386711
chr16:21691353:G>A
OTOA
NM_144672:c.179+821G>A
INTRON4
Benign
rs116615159
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
30
1322
0.0227
0
1006
0
2
694
0.0029
0
1008
0
0
978
0
32
5008
0.00638978
386712
chr16:21691387:G>C
OTOA
NM_144672:c.179+855G>C
INTRON4
Unknown significance
rs565474685
This variant is a VUS because it does not have enough information.
386713
chr16:21691429:C>-
OTOA
NM_144672:c.179+897delC
INTRON4
Benign
rs551074628
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0
1322
0
0
1006
0
5
694
0.0072
0
1008
0
0
978
0
5
5008
0.000998403
386714
chr16:21691461:T>G
OTOA
NM_144672:c.179+929T>G
INTRON4
Benign
rs142271874
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
11
1322
0.0083
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
12
5008
0.00239617
386715
chr16:21691471:C>A
OTOA
NM_144672:c.179+939C>A
INTRON4
Benign
rs7194128
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
582
1322
0.4402
90
1006
0.0895
155
694
0.2233
292
1008
0.2897
102
978
0.1043
1221
5008
0.24381
386716
chr16:21691504:T>C
OTOA
NM_144672:c.179+972T>C
INTRON4
Unknown significance
rs138864625
This variant is a VUS because it does not have enough information.
386717
chr16:21691505:T>C
OTOA
NM_144672:c.179+973T>C
INTRON4
Unknown significance
rs148311668
This variant is a VUS because it does not have enough information.
386718
chr16:21691506:->ATCC
OTOA
NM_144672:c.179+974_179+975insATCC
INTRON4
Unknown significance
rs143747290
This variant is a VUS because it does not have enough information.
386719
chr16:21691506:->ATCCATCC
OTOA
NM_144672:c.179+974_179+975insATCCATCC
INTRON4
Unknown significance
rs143747290
This variant is a VUS because it does not have enough information.
386720
chr16:21691506:->ATCCATCCATCC
OTOA
NM_144672:c.179+974_179+975insATCCATCCATCC
INTRON4
Unknown significance
rs143747290
This variant is a VUS because it does not have enough information.
386721
chr16:21691506:->ATCCATCCATCCATCC
OTOA
NM_144672:c.179+974_179+975insATCCATCCATCCATCC
INTRON4
Unknown significance
rs143747290
This variant is a VUS because it does not have enough information.
386722
chr16:21691506:->ATCCATCCATCCATCCATCC
OTOA
NM_144672:c.179+974_179+975insATCCATCCATCCATCCATCC
INTRON4
Unknown significance
rs143747290
This variant is a VUS because it does not have enough information.
386723
chr16:21691510:A>G
OTOA
NM_144672:c.179+978A>G
INTRON4
Unknown significance
rs181702985
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386724
chr16:21691530:A>C
OTOA
NM_144672:c.179+998A>C
INTRON4
Unknown significance
rs575650557
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386725
chr16:21691555:C>A
OTOA
NM_144672:c.179+1023C>A
INTRON4
Unknown significance
rs546269947
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386726
chr16:21691561:G>A
OTOA
NM_144672:c.179+1029G>A
INTRON4
Unknown significance
rs558176481
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
1
694
0.0014
0
1008
0
1
978
0.001
2
5008
0.000399361
386727
chr16:21691570:C>T
OTOA
NM_144672:c.179+1038C>T
INTRON4
Unknown significance
rs573210344
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386728
chr16:21691577:A>G
OTOA
NM_144672:c.179+1045A>G
INTRON4
Benign
rs74643689
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
4
1322
0.003
195
1006
0.1938
64
694
0.0922
0
1008
0
19
978
0.0194
282
5008
0.0563099
386729
chr16:21691587:G>C
OTOA
NM_144672:c.179+1055G>C
INTRON4
Benign
rs58398187
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
604
1322
0.4569
98
1006
0.0974
157
694
0.2262
390
1008
0.3869
110
978
0.1125
1359
5008
0.271366
386730
chr16:21691589:C>T
OTOA
NM_144672:c.179+1057C>T
INTRON4
Unknown significance
rs529093451
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386731
chr16:21691631:G>A
OTOA
NM_144672:c.179+1099G>A
INTRON4
Unknown significance
rs368201997
This variant is a VUS because it does not have enough information.
386732
chr16:21691665:C>T
OTOA
NM_144672:c.179+1133C>T
INTRON4
Unknown significance
rs544354001
This variant is a VUS because it does not have enough information.
5
1322
0.0038
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
6
5008
0.00119808
386733
chr16:21691676:T>C
OTOA
NM_144672:c.179+1144T>C
INTRON4
Unknown significance
rs562445126
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386734
chr16:21691701:G>C
OTOA
NM_144672:c.179+1169G>C
INTRON4
Unknown significance
rs780664179
This variant is a VUS because it does not have enough information.
386735
chr16:21691705:C>T
OTOA
NM_144672:c.179+1173C>T
INTRON4
Unknown significance
rs532859161
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
2
1008
0.002
0
978
0
2
5008
0.000399361
386736
chr16:21691738:G>A
OTOA
NM_144672:c.179+1206G>A
INTRON4
Unknown significance
rs551000752
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386737
chr16:21691757:C>T
OTOA
NM_144672:c.179+1225C>T
INTRON4
Unknown significance
rs566114666
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386738
chr16:21691759:C>T
OTOA
NM_144672:c.179+1227C>T
INTRON4
Unknown significance
rs528785034
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
1
694
0.0014
0
1008
0
4
978
0.0041
5
5008
0.000998403
386739
chr16:21691760:G>A
OTOA
NM_144672:c.179+1228G>A
INTRON4
Unknown significance
rs756380137
This variant is a VUS because it does not have enough information.
386740
chr16:21691764:G>C
OTOA
NM_144672:c.179+1232G>C
INTRON4
Unknown significance
rs551475589
This variant is a VUS because it does not have enough information.
386741
chr16:21691771:G>A
OTOA
NM_144672:c.179+1239G>A
INTRON4
Unknown significance
rs186049233
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386742
chr16:21691798:G>A
OTOA
NM_144672:c.180-1261G>A
INTRON4
Benign
rs192510438
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
19
1322
0.0144
0
1006
0
0
694
0
0
1008
0
0
978
0
19
5008
0.00379393
386743
chr16:21691813:C>T
OTOA
NM_144672:c.180-1246C>T
INTRON4
Unknown significance
rs753941609
This variant is a VUS because it does not have enough information.
386744
chr16:21691833:G>A
OTOA
NM_144672:c.180-1226G>A
INTRON4
Unknown significance
rs757181064
This variant is a VUS because it does not have enough information.
386745
chr16:21691836:->AAAC
OTOA
NM_144672:c.180-1223_180-1222insAAAC
INTRON4
Unknown significance
rs566695464
This variant is a VUS because it does not have enough information.
386746
chr16:21691836:AAAC>-
OTOA
NM_144672:c.180-1223_180-1220delAAAC
INTRON4
Unknown significance
rs146969285
This variant is a VUS because it does not have enough information.
386747
chr16:21691836:AAACAAAC>-
OTOA
NM_144672:c.180-1223_180-1216delAAACAAAC
INTRON4
Unknown significance
rs777337006
This variant is a VUS because it does not have enough information.
386748
chr16:21691867:C>G
OTOA
NM_144672:c.180-1192C>G
INTRON4
Unknown significance
rs151255712
This variant is a VUS because it does not have enough information.
386749
chr16:21691945:A>G
OTOA
NM_144672:c.180-1114A>G
INTRON4
Benign
rs28657714
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
605
1322
0.4576
90
1006
0.0895
156
694
0.2248
291
1008
0.2887
103
978
0.1053
1245
5008
0.248602
386750
chr16:21691953:C>T
OTOA
NM_144672:c.180-1106C>T
INTRON4
Unknown significance
rs749810961
This variant is a VUS because it does not have enough information.
386751
chr16:21691954:G>A
OTOA
NM_144672:c.180-1105G>A
INTRON4
Benign
rs145464941
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
1
1322
0.0008
6
1006
0.006
1
694
0.0014
0
1008
0
0
978
0
8
5008
0.00159744
386752
chr16:21691975:C>T
OTOA
NM_144672:c.180-1084C>T
INTRON4
Unknown significance
rs569295724
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
0
978
0
0
5008
0
386753
chr16:21691982:C>T
OTOA
NM_144672:c.180-1077C>T
INTRON4
Unknown significance
rs774552776
This variant is a VUS because it does not have enough information.
386754
chr16:21691983:G>A
OTOA
NM_144672:c.180-1076G>A
INTRON4
Unknown significance
rs367859705
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
4
1008
0.004
0
978
0
4
5008
0.000798722
386755
chr16:21692031:G>T
OTOA
NM_144672:c.180-1028G>T
INTRON4
Unknown significance
rs558213164
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386756
chr16:21692032:G>T
OTOA
NM_144672:c.180-1027G>T
INTRON4
Unknown significance
rs573297799
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386757
chr16:21692047:G>A
OTOA
NM_144672:c.180-1012G>A
INTRON4
Unknown significance
rs540598583
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
1
5008
0.000199681
386758
chr16:21692089:G>A
OTOA
NM_144672:c.180-970G>A
INTRON4
Unknown significance
rs555384304
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386759
chr16:21692091:T>C
OTOA
NM_144672:c.180-968T>C
INTRON4
Unknown significance
rs772226582
This variant is a VUS because it does not have enough information.
386760
chr16:21692098:T>C
OTOA
NM_144672:c.180-961T>C
INTRON4
Unknown significance
rs573833328
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386761
chr16:21692105:C>T
OTOA
NM_144672:c.180-954C>T
INTRON4
Unknown significance
rs544124151
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
1
5008
0.000199681
386762
chr16:21692106:G>A
OTOA
NM_144672:c.180-953G>A
INTRON4
Benign
rs147712987
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0
1322
0
8
1006
0.008
1
694
0.0014
52
1008
0.0516
3
978
0.0031
64
5008
0.0127796
386763
chr16:21692116:G>A
OTOA
NM_144672:c.180-943G>A
INTRON4
Unknown significance
rs758297983
This variant is a VUS because it does not have enough information.
386764
chr16:21692130:C>A
OTOA
NM_144672:c.180-929C>A
INTRON4
Unknown significance
rs779925018
This variant is a VUS because it does not have enough information.
386765
chr16:21692131:A>G
OTOA
NM_144672:c.180-928A>G
INTRON4
Unknown significance
rs746670957
This variant is a VUS because it does not have enough information.
386767
chr16:21692168:T>A
OTOA
NM_144672:c.180-891T>A
INTRON4
Unknown significance
rs532896008
This variant is a VUS because it does not have enough information.
386766
chr16:21692168:T>C
OTOA
NM_144672:c.180-891T>C
INTRON4
Unknown significance
rs532896008
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386768
chr16:21692174:C>A
OTOA
NM_144672:c.180-885C>A
INTRON4
Unknown significance
rs75996092
This variant is a VUS because it does not have enough information.
386769
chr16:21692175:A>C
OTOA
NM_144672:c.180-884A>C
INTRON4
Unknown significance
rs75257066
This variant is a VUS because it does not have enough information.
386770
chr16:21692191:A>G
OTOA
NM_144672:c.180-868A>G
INTRON4
Benign
rs532667148
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0
1322
0
0
1006
0
0
694
0
0
1008
0
8
978
0.0082
8
5008
0.00159744
386771
chr16:21692208:A>G
OTOA
NM_144672:c.180-851A>G
INTRON4
Unknown significance
rs780629413
This variant is a VUS because it does not have enough information.
386772
chr16:21692241:C>T
OTOA
NM_144672:c.180-818C>T
INTRON4
Unknown significance
rs559786532
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
1
5008
0.000199681
386773
chr16:21692247:T>A
OTOA
NM_144672:c.180-812T>A
INTRON4
Unknown significance
rs567937888
This variant is a VUS because it does not have enough information.
386774
chr16:21692256:T>G
OTOA
NM_144672:c.180-803T>G
INTRON4
Unknown significance
rs527302624
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
1
978
0.001
2
5008
0.000399361
386775
chr16:21692311:G>A
OTOA
NM_144672:c.180-748G>A
INTRON4
Benign
rs115473521
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
58
1322
0.0439
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
59
5008
0.0117812
386776
chr16:21692315:C>A
OTOA
NM_144672:c.180-744C>A
INTRON4
Unknown significance
rs375060757
This variant is a VUS because it does not have enough information.
386777
chr16:21692338:C>T
OTOA
NM_144672:c.180-721C>T
INTRON4
Unknown significance
rs562294810
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386778
chr16:21692393:C>T
OTOA
NM_144672:c.180-666C>T
INTRON4
Unknown significance
rs529584595
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386779
chr16:21692399:A>C
OTOA
NM_144672:c.180-660A>C
INTRON4
Unknown significance
rs769470747
This variant is a VUS because it does not have enough information.
386780
chr16:21692401:TA>-
OTOA
NM_144672:c.180-658_180-657delTA
INTRON4
Unknown significance
rs538200986
This variant is a VUS because it does not have enough information.
1
1322
0.0008
2
1006
0.002
0
694
0
0
1008
0
0
978
0
3
5008
0.000599042
386781
chr16:21692415:C>A
OTOA
NM_144672:c.180-644C>A
INTRON4
Unknown significance
rs775394412
This variant is a VUS because it does not have enough information.
386782
chr16:21692417:C>T
OTOA
NM_144672:c.180-642C>T
INTRON4
Unknown significance
rs762852456
This variant is a VUS because it does not have enough information.
386783
chr16:21692440:T>G
OTOA
NM_144672:c.180-619T>G
INTRON4
Unknown significance
rs550930431
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386784
chr16:21692477:T>C
OTOA
NM_144672:c.180-582T>C
INTRON4
Unknown significance
rs75422939
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
2
1008
0.002
0
978
0
2
5008
0.000399361
386785
chr16:21692504:G>A
OTOA
NM_144672:c.180-555G>A
INTRON4
Unknown significance
rs796384535
This variant is a VUS because it does not have enough information.
386786
chr16:21692591:A>G
OTOA
NM_144672:c.180-468A>G
INTRON4
Unknown significance
rs142543205
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386787
chr16:21692654:G>A
OTOA
NM_144672:c.180-405G>A
INTRON4
Unknown significance
rs556891468
This variant is a VUS because it does not have enough information.
386788
chr16:21692664:T>C
OTOA
NM_144672:c.180-395T>C
INTRON4
Benign
rs215893
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
1311
1322
0.9917
882
1006
0.8767
533
694
0.768
676
1008
0.6706
702
978
0.7178
4104
5008
0.819489
386789
chr16:21692701:C>A
OTOA
NM_144672:c.180-358C>A
INTRON4
Unknown significance
rs566930128
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
4
978
0.0041
4
5008
0.000798722
386790
chr16:21692714:C>G
OTOA
NM_144672:c.180-345C>G
INTRON4
Unknown significance
rs539514843
This variant is a VUS because it does not have enough information.
386791
chr16:21692723:G>A
OTOA
NM_144672:c.180-336G>A
INTRON4
Unknown significance
rs534186760
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386792
chr16:21692759:C>G
OTOA
NM_144672:c.180-300C>G
INTRON4
Unknown significance
rs558759408
This variant is a VUS because it does not have enough information.
386793
chr16:21692816:A>T
OTOA
NM_144672:c.180-243A>T
INTRON4
Unknown significance
rs557891893
This variant is a VUS because it does not have enough information.
386794
chr16:21692852:C>T
OTOA
NM_144672:c.180-207C>T
INTRON4
Unknown significance
rs372707474
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386795
chr16:21692853:G>A
OTOA
NM_144672:c.180-206G>A
INTRON4
Unknown significance
rs751524829
This variant is a VUS because it does not have enough information.
386796
chr16:21692865:C>T
OTOA
NM_144672:c.180-194C>T
INTRON4
Unknown significance
rs573892147
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386797
chr16:21692900:A>G
OTOA
NM_144672:c.180-159A>G
INTRON4
Unknown significance
rs538126577
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
1
5008
0.000199681
386798
chr16:21692907:->AAAGA
OTOA
NM_144672:c.180-152_180-151insAAAGA
INTRON4
Unknown significance
rs558851068
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
2
978
0.002
3
5008
0.000599042
386799
chr16:21692954:C>A
OTOA
NM_144672:c.180-105C>A
INTRON4
Unknown significance
rs556111128
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386800
chr16:21692993:C>G
OTOA
NM_144672:c.180-66C>G
INTRON4
Unknown significance
rs117245113
This variant is a VUS because it does not have enough information.
0
1322
0
2
1006
0.002
0
694
0
0
1008
0
0
978
0
2
5008
0.000399361
386801
chr16:21693012:A>T
OTOA
NM_144672:c.180-47A>T
INTRON4
Unknown significance
rs544767087
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
0
10132
0
0
11124
0
0
8444
0
0
6402
0
0
65336
0
0
876
0
2
15812
0.000126486
2
118126
0.0000169311
386802
chr16:21693016:G>C
OTOA
NM_144672:c.180-43G>C
INTRON4
Unknown significance
rs760043999
This variant is a VUS because it does not have enough information.
0
10150
0
0
11142
0
2
8446
0.000236798
0
6398
0
0
65366
0
0
882
0
0
15850
0
2
118234
0.0000169156
386803
chr16:21693033:C>A
OTOA
NM_144672:c.180-26C>A
INTRON4
Unknown significance
rs200586771
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386804
chr16:21693044:T>C
OTOA
NM_144672:c.180-15T>C
INTRON4
Unknown significance
rs750035094
This variant is a VUS because it does not have enough information.
0
10334
0
0
11412
0
1
8634
0.000115821
0
6522
0
1
66374
0.0000150661
0
896
0
0
16220
0
2
120392
0.0000166124
386805
chr16:21693047:C>T
OTOA
NM_144672:c.180-12C>T
INTRON4
Unknown significance
rs776210902
This variant is a VUS because it does not have enough information.
0
10350
0
3
11448
0.000262055
0
8638
0
0
6534
0
4
66460
0.0000601866
0
898
0
0
16282
0
7
120610
0.0000580383
386806
chr16:21693053:C>T
OTOA
NM_144672:c.180-6C>T
INTRON4
Unknown significance
rs761492464
This variant is a VUS because it does not have enough information.
0
10376
0
0
11486
0
0
8652
0
0
6552
0
0
66560
0
0
898
0
1
16366
0.0000611023
1
120890
0.00000827198
386807
chr16:21693060:T>G
OTOA
NM_144672:p.Ser61Ala
NM_144672:c.181T>G
EXON5
Unknown significance
rs369772866
This variant is a VUS because it does not have enough information.
1.061
C
0.13;0.138
T
0.016
B
0.006618
N
0.669736
D
0.695
C
1
8600
0.000116279
0
4398
0
1
12998
0.0000769349
386808
chr16:21693066:G>A
OTOA
NM_144672:p.Val63Met
NM_144672:c.187G>A
EXON5
Likely benign
rs755864812
Pathogenicity is based on prediction data only. 1 out of 6 predictions were pathogenic.
-1.55
N
0.208;0.214
T
0.018
B
0.174906
N
1
N
0.582
C
0
10396
0
0
11542
0
0
8654
0
0
6592
0
3
66670
0.0000449978
0
908
0
2
16454
0.000121551
5
121216
0.0000412487
386809
chr16:21693066:G>T
OTOA
NM_144672:p.Val63Leu
NM_144672:c.187G>T
EXON5
Likely benign
rs755864812
Pathogenicity is based on prediction data only. 1 out of 6 predictions were pathogenic.
-1.55
N
0.265;0.308
T
0.019
B
0.174906
N
1
N
0.582
C
0
10396
0
0
11542
0
0
8654
0
0
6592
0
2
66670
0.0000299985
0
908
0
0
16454
0
2
121216
0.0000164995
386811
chr16:21693073:C>A
OTOA
NM_144672:p.Thr65Lys
NM_144672:c.194C>A
EXON5
Unknown significance
rs140152105
This variant is a VUS because it does not have enough information.
0.068
N
0.0
D
1.0
D
0.000001
D
0.995987
D
4.98
C
3
10400
0.000288462
0
11554
0
0
8654
0
0
6596
0
0
66698
0
0
908
0
0
16466
0
3
121276
0.000024737
386810
chr16:21693073:C>T
OTOA
NM_144672:p.Thr65Met
NM_144672:c.194C>T
EXON5
Unknown significance
rs140152105
This variant is a VUS because it does not have enough information.
0.068
N
0.0
D
1.0
D
0.000001
D
0.992776
D
4.98
C
1
8600
0.000116279
1
4398
0.000227376
2
12998
0.00015387
0
1322
0
0
1006
0
0
694
0
0
1008
0
2
978
0.002
2
5008
0.000399361
0
10400
0
1
11554
0.0000865501
3
8654
0.000346661
0
6596
0
10
66698
0.00014993
0
908
0
9
16466
0.000546581
23
121276
0.00018965
386812
chr16:21693093:G>A
OTOA
NM_144672:p.Val72Ile
NM_144672:c.214G>A
EXON5
Likely benign
rs373454098
Pathogenicity is based on prediction data only. 1 out of 6 predictions were pathogenic.
-0.67
N
0.235;0.246
T
0.011
B
0.033588
N
0.956944
N
0.166
C
1
8600
0.000116279
0
4398
0
1
12998
0.0000769349
0
10406
0
0
11564
0
0
8654
0
0
6606
0
1
66720
0.000014988
0
908
0
0
16490
0
1
121348
0.00000824076
386813
chr16:21693105:C>G
OTOA
NM_144672:p.Leu76Val
NM_144672:c.226C>G
EXON5
Unknown significance
rs756208278
This variant is a VUS because it does not have enough information.
0.935
N
0.023;0.026
D
0.925
P
0.034187
N
0.833667
N
3.81
C
0
10406
0
0
11560
0
0
8654
0
0
6606
0
2
66720
0.000029976
0
908
0
0
16500
0
2
121354
0.0000164807
386814
chr16:21693106:T>C
OTOA
NM_144672:p.Leu76Pro
NM_144672:c.227T>C
EXON5
Unknown significance
rs777905759
This variant is a VUS because it does not have enough information.
1.061
C
0.004
D
0.996
D
0.034187
N
0.999996
D
4.81
C
386815
chr16:21693114:C>T
OTOA
NM_144672:p.Arg79Trp
NM_144672:c.235C>T
EXON5
Likely benign
rs754047945
Pathogenicity is based on prediction data only. 2 out of 6 predictions were pathogenic.
0.02
N
0.048;0.051
D;T
0.116
B
0.397645
N
1
N
1.41
C
0
10406
0
0
11560
0
0
8654
0
0
6604
0
0
66712
0
0
908
0
1
16500
0.0000606061
1
121344
0.00000824103
386816
chr16:21693115:G>A
OTOA
NM_144672:p.Arg79Gln
NM_144672:c.236G>A
EXON5
Likely benign
rs147088274
Pathogenicity is based on prediction data only. 0 out of 6 predictions were pathogenic.
-0.668
N
0.442;0.459
T
0.093
B
0.397645
N
1
N
-0.664
N
1
8600
0.000116279
15
4398
0.00341064
16
12998
0.00123096
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
38
10404
0.00365244
1
11558
0.0000865202
0
8654
0
0
6606
0
1
66712
0.0000149898
1
908
0.00110132
0
16500
0
41
121342
0.000337888
386817
chr16:21693116:G>C
OTOA
NM_144672:p.Arg79Arg
NM_144672:c.237G>C
EXON5
Unknown significance
rs779280512
This variant is a VUS because it does not have enough information.
1
10406
0.0000960984
0
11558
0
0
8654
0
0
6604
0
0
66714
0
0
908
0
0
16500
0
1
121344
0.00000824103
386818
chr16:21693123:G>A
OTOA
NM_144672:p.Ala82Thr
NM_144672:c.244G>A
EXON5
Likely benign
rs200249536
Pathogenicity is based on prediction data only. 0 out of 6 predictions were pathogenic.
-1.096
N
0.345;0.381
T
0.003
B
0.131565
N
0.999995
N
-4.64
N
0
10404
0
0
11556
0
0
8654
0
0
6604
0
4
66700
0.00005997
0
908
0
0
16494
0
4
121320
0.0000329707
386819
chr16:21693124:C>A
OTOA
NM_144672:p.Ala82Asp
NM_144672:c.245C>A
EXON5
Likely benign
rs772578617
Pathogenicity is based on prediction data only. 1 out of 6 predictions were pathogenic.
0.935
N
0.356;0.396
T
0.003
B
0.131565
N
0.578805
N
4.98
C
0
10404
0
0
11556
0
0
8654
0
0
6600
0
1
66698
0.000014993
0
908
0
0
16490
0
1
121310
0.00000824334
386820
chr16:21693125:C>G
OTOA
NM_144672:p.Ala82Ala
NM_144672:c.246C>G
EXON5
Unknown significance
rs780595280
This variant is a VUS because it does not have enough information.
0
10404
0
0
11556
0
1
8654
0.000115554
0
6600
0
0
66698
0
0
908
0
0
16490
0
1
121310
0.00000824334
386821
chr16:21693129:A>C
OTOA
NM_144672:p.Thr84Pro
NM_144672:c.250A>C
EXON5
Unknown significance
This variant is a VUS because it does not have enough information.
1.199
C
0.004;0.005
D
1.0
D
0.000181
D
0.992364
D
5.93
C
0
400
0
0
320
0
0
320
0
0
400
0
0
360
0
0
200
0
0
2000
0
386822
chr16:21693134:C>T
OTOA
NM_144672:p.Ile85Ile
NM_144672:c.255C>T
EXON5
Unknown significance
rs371085958
This variant is a VUS because it does not have enough information.
0
8600
0
1
4398
0.000227376
1
12998
0.0000769349
4
10402
0.000384541
0
11542
0
0
8654
0
0
6592
0
0
66682
0
0
908
0
0
16486
0
4
121266
0.0000329853
386823
chr16:21693140:C>A
OTOA
NM_144672:p.Ser87Arg
NM_144672:c.261C>A
EXON5
Unknown significance
rs376927793
This variant is a VUS because it does not have enough information.
0.935
N
0.004
D
0.999
D
0
D
0.99233
D
4.8
C
1
8600
0.000116279
0
4398
0
1
12998
0.0000769349
0
10398
0
0
11524
0
0
8654
0
1
6588
0.000151791
8
66672
0.00011999
0
908
0
0
16472
0
9
121216
0.0000742476
386824
chr16:21693141:C>T
OTOA
NM_144672:p.Leu88Leu
NM_144672:c.262C>T
EXON5
Unknown significance
rs776180718
This variant is a VUS because it does not have enough information.
1
10396
0.0000961908
0
11524
0
0
8654
0
0
6586
0
0
66666
0
0
908
0
0
16470
0
1
121204
0.00000825055
386825
chr16:21693158:A>G
OTOA
NM_144672:c.267+12A>G
INTRON5
Unknown significance
rs747774114
This variant is a VUS because it does not have enough information.
0
10364
0
0
11458
0
1
8652
0.00011558
0
6564
0
0
66558
0
0
906
0
0
16412
0
1
120914
0.00000827034
386826
chr16:21693163:C>T
OTOA
NM_144672:c.267+17C>T
INTRON5
Unknown significance
rs769534844
This variant is a VUS because it does not have enough information.
0
10358
0
0
11438
0
0
8642
0
0
6562
0
0
66510
0
0
904
0
2
16398
0.000121966
2
120812
0.0000165546
386827
chr16:21693164:A>T
OTOA
NM_144672:c.267+18A>T
INTRON5
Unknown significance
rs773149989
This variant is a VUS because it does not have enough information.
0
10356
0
0
11434
0
0
8646
0
0
6562
0
1
66506
0.0000150362
0
904
0
0
16400
0
1
120808
0.0000082776
386828
chr16:21693165:T>A
OTOA
NM_144672:c.267+19T>A
INTRON5
Unknown significance
rs762780701
This variant is a VUS because it does not have enough information.
0
10354
0
0
11426
0
0
8644
0
0
6558
0
1
66490
0.0000150399
0
904
0
0
16398
0
1
120774
0.00000827993
386829
chr16:21693173:->T
OTOA
NM_144672:c.267+27_267+28insT
INTRON5
Unknown significance
rs34356730
This variant is a VUS because it does not have enough information.
386830
chr16:21693191:G>A
OTOA
NM_144672:c.267+45G>A
INTRON5
Unknown significance
rs766266628
This variant is a VUS because it does not have enough information.
0
10300
0
0
11310
0
1
8582
0.000116523
0
6500
0
0
66174
0
0
900
0
0
16274
0
1
120040
0.00000833056
386831
chr16:21693197:G>A
OTOA
NM_144672:c.267+51G>A
INTRON5
Unknown significance
rs774223142
This variant is a VUS because it does not have enough information.
0
10236
0
0
11228
0
1
8526
0.000117288
0
6478
0
0
65884
0
0
896
0
0
16188
0
1
119436
0.00000837268
386832
chr16:21693217:A>G
OTOA
NM_144672:c.267+71A>G
INTRON5
Unknown significance
rs560924868
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386833
chr16:21693264:G>A
OTOA
NM_144672:c.267+118G>A
INTRON5
Unknown significance
rs12447559
This variant is a VUS because it does not have enough information.
386834
chr16:21693271:G>C
OTOA
NM_144672:c.267+125G>C
INTRON5
Unknown significance
rs780253312
This variant is a VUS because it does not have enough information.
386835
chr16:21693277:T>C
OTOA
NM_144672:c.267+131T>C
INTRON5
Unknown significance
rs529590101
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
0
978
0
0
5008
0
386836
chr16:21693298:A>G
OTOA
NM_144672:c.267+152A>G
INTRON5
Unknown significance
rs149013870
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386837
chr16:21693314:C>T
OTOA
NM_144672:c.267+168C>T
INTRON5
Unknown significance
rs563142507
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386838
chr16:21693322:C>T
OTOA
NM_144672:c.267+176C>T
INTRON5
Unknown significance
rs754305836
This variant is a VUS because it does not have enough information.
386839
chr16:21693327:T>C
OTOA
NM_144672:c.267+181T>C
INTRON5
Unknown significance
rs570566627
This variant is a VUS because it does not have enough information.
386840
chr16:21693343:G>C
OTOA
NM_144672:c.267+197G>C
INTRON5
Unknown significance
rs533575162
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386841
chr16:21693388:C>A
OTOA
NM_144672:c.267+242C>A
INTRON5
Unknown significance
rs573035458
This variant is a VUS because it does not have enough information.
386842
chr16:21693417:A>G
OTOA
NM_144672:c.267+271A>G
INTRON5
Unknown significance
rs551958194
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386843
chr16:21693433:G>A
OTOA
NM_144672:c.267+287G>A
INTRON5
Unknown significance
rs567017627
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386844
chr16:21693437:A>C
OTOA
NM_144672:c.267+291A>C
INTRON5
Unknown significance
rs755418871
This variant is a VUS because it does not have enough information.
386845
chr16:21693536:T>C
OTOA
NM_144672:c.267+390T>C
INTRON5
Benign
rs143017378
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
19
1322
0.0144
0
1006
0
2
694
0.0029
0
1008
0
0
978
0
21
5008
0.00419329
386846
chr16:21693558:T>C
OTOA
NM_144672:c.267+412T>C
INTRON5
Unknown significance
rs540420834
This variant is a VUS because it does not have enough information.
0
1322
0
3
1006
0.003
2
694
0.0029
0
1008
0
0
978
0
5
5008
0.000998403
386847
chr16:21693565:G>A
OTOA
NM_144672:c.267+419G>A
INTRON5
Unknown significance
rs567628489
This variant is a VUS because it does not have enough information.
5
1322
0.0038
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
6
5008
0.00119808
386848
chr16:21693585:C>T
OTOA
NM_144672:c.267+439C>T
INTRON5
Unknown significance
rs537820457
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386849
chr16:21693589:C>T
OTOA
NM_144672:c.267+443C>T
INTRON5
Unknown significance
rs183906848
This variant is a VUS because it does not have enough information.
386850
chr16:21693592:G>A
OTOA
NM_144672:c.267+446G>A
INTRON5
Benign
rs115156928
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
17
1322
0.0129
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
18
5008
0.00359425
386851
chr16:21693623:G>A
OTOA
NM_144672:c.267+477G>A
INTRON5
Unknown significance
rs577471865
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386852
chr16:21693632:C>T
OTOA
NM_144672:c.267+486C>T
INTRON5
Unknown significance
rs538094046
This variant is a VUS because it does not have enough information.
386853
chr16:21693647:C>A
OTOA
NM_144672:c.267+501C>A
INTRON5
Unknown significance
rs538447233
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386854
chr16:21693648:G>A
OTOA
NM_144672:c.267+502G>A
INTRON5
Unknown significance
rs553544171
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386855
chr16:21693653:T>C
OTOA
NM_144672:c.267+507T>C
INTRON5
Unknown significance
rs571846621
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386856
chr16:21693680:A>G
OTOA
NM_144672:c.267+534A>G
INTRON5
Unknown significance
rs542687122
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386857
chr16:21693695:A>G
OTOA
NM_144672:c.267+549A>G
INTRON5
Benign
rs117610946
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0
1322
0
0
1006
0
0
694
0
32
1008
0.0317
1
978
0.001
33
5008
0.00658946
386858
chr16:21693709:C>T
OTOA
NM_144672:c.267+563C>T
INTRON5
Unknown significance
rs188905872
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386859
chr16:21693717:G>A
OTOA
NM_144672:c.267+571G>A
INTRON5
Unknown significance
rs148197104
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386860
chr16:21693723:T>C
OTOA
NM_144672:c.267+577T>C
INTRON5
Unknown significance
rs190852481
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386861
chr16:21693728:C>T
OTOA
NM_144672:c.267+582C>T
INTRON5
Unknown significance
rs533664203
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386862
chr16:21693762:G>A
OTOA
NM_144672:c.267+616G>A
INTRON5
Unknown significance
rs772031924
This variant is a VUS because it does not have enough information.
386863
chr16:21693821:A>G
OTOA
NM_144672:c.267+675A>G
INTRON5
Unknown significance
rs545658378
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386864
chr16:21693824:T>C
OTOA
NM_144672:c.267+678T>C
INTRON5
Unknown significance
rs371188477
This variant is a VUS because it does not have enough information.
386865
chr16:21693838:A>G
OTOA
NM_144672:c.267+692A>G
INTRON5
Unknown significance
rs560652283
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386866
chr16:21693874:A>G
OTOA
NM_144672:c.267+728A>G
INTRON5
Unknown significance
rs527810183
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386867
chr16:21693902:G>A
OTOA
NM_144672:c.267+756G>A
INTRON5
Unknown significance
rs777973220
This variant is a VUS because it does not have enough information.
386868
chr16:21693921:C>T
OTOA
NM_144672:c.267+775C>T
INTRON5
Unknown significance
rs772431775
This variant is a VUS because it does not have enough information.
386869
chr16:21693922:G>A
OTOA
NM_144672:c.267+776G>A
INTRON5
Unknown significance
rs747167230
This variant is a VUS because it does not have enough information.
386870
chr16:21693957:A>G
OTOA
NM_144672:c.267+811A>G
INTRON5
Unknown significance
rs771231191
This variant is a VUS because it does not have enough information.
386871
chr16:21694006:T>C
OTOA
NM_144672:c.267+860T>C
INTRON5
Unknown significance
rs182112735
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
2
694
0.0029
0
1008
0
0
978
0
2
5008
0.000399361
386872
chr16:21694015:A>G
OTOA
NM_144672:c.267+869A>G
INTRON5
Unknown significance
rs776857725
This variant is a VUS because it does not have enough information.
386873
chr16:21694019:C>A
OTOA
NM_144672:c.267+873C>A
INTRON5
Unknown significance
rs567617863
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386874
chr16:21694078:G>A
OTOA
NM_144672:c.267+932G>A
INTRON5
Unknown significance
rs374952485
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386876
chr16:21694093:->ATA
OTOA
NM_144672:c.267+947_267+948insATA
INTRON5
Unknown significance
rs746778542
This variant is a VUS because it does not have enough information.
386875
chr16:21694093:ATA>-
OTOA
NM_144672:c.267+947_267+949delATA
INTRON5
Benign
rs145027265
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
472
1322
0.357
84
1006
0.0835
146
694
0.2104
295
1008
0.2927
117
978
0.1196
1114
5008
0.222444
386877
chr16:21694095:A>T
OTOA
NM_144672:c.267+949A>T
INTRON5
Benign
rs549714550
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
20
1322
0.0151
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
21
5008
0.00419329
386878
chr16:21694112:A>G
OTOA
NM_144672:c.267+966A>G
INTRON5
Unknown significance
rs369140998
This variant is a VUS because it does not have enough information.
386879
chr16:21694236:A>G
OTOA
NM_144672:c.267+1090A>G
INTRON5
Unknown significance
rs762694891
This variant is a VUS because it does not have enough information.
386880
chr16:21694238:A>G
OTOA
NM_144672:c.267+1092A>G
INTRON5
Unknown significance
rs768441392
This variant is a VUS because it does not have enough information.
386881
chr16:21694296:C>T
OTOA
NM_144672:c.267+1150C>T
INTRON5
Unknown significance
rs774218924
This variant is a VUS because it does not have enough information.
386882
chr16:21694358:C>T
OTOA
NM_144672:c.267+1212C>T
INTRON5
Unknown significance
rs187112216
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
2
694
0.0029
0
1008
0
0
978
0
2
5008
0.000399361
386883
chr16:21694391:T>C
OTOA
NM_144672:c.267+1245T>C
INTRON5
Unknown significance
rs538532768
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386884
chr16:21694398:A>T
OTOA
NM_144672:c.267+1252A>T
INTRON5
Unknown significance
rs191623934
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386885
chr16:21694420:G>A
OTOA
NM_144672:c.267+1274G>A
INTRON5
Unknown significance
rs141603664
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
3
978
0.0031
4
5008
0.000798722
386886
chr16:21694449:G>T
OTOA
NM_144672:c.267+1303G>T
INTRON5
Unknown significance
rs536026397
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
2
1008
0.002
0
978
0
2
5008
0.000399361
386887
chr16:21694451:G>A
OTOA
NM_144672:c.267+1305G>A
INTRON5
Unknown significance
rs146213838
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386888
chr16:21694463:G>A
OTOA
NM_144672:c.267+1317G>A
INTRON5
Unknown significance
rs576007540
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
1
978
0.001
2
5008
0.000399361
386889
chr16:21694473:G>T
OTOA
NM_144672:c.267+1327G>T
INTRON5
Unknown significance
rs111866476
This variant is a VUS because it does not have enough information.
386890
chr16:21694515:G>A
OTOA
NM_144672:c.267+1369G>A
INTRON5
Unknown significance
rs760945946
This variant is a VUS because it does not have enough information.
386891
chr16:21694549:T>C
OTOA
NM_144672:c.267+1403T>C
INTRON5
Benign
rs547556633
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0
1322
0
0
1006
0
0
694
0
0
1008
0
16
978
0.0164
16
5008
0.00319489
386892
chr16:21694550:AG>-
OTOA
NM_144672:c.267+1404_267+1405delAG
INTRON5
Unknown significance
rs765672810
This variant is a VUS because it does not have enough information.
386893
chr16:21694570:A>G
OTOA
NM_144672:c.267+1424A>G
INTRON5
Unknown significance
rs558577918
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386894
chr16:21694576:C>T
OTOA
NM_144672:c.267+1430C>T
INTRON5
Unknown significance
rs760223800
This variant is a VUS because it does not have enough information.
386895
chr16:21694626:C>T
OTOA
NM_144672:c.267+1480C>T
INTRON5
Unknown significance
rs764373372
This variant is a VUS because it does not have enough information.
386896
chr16:21694646:A>G
OTOA
NM_144672:c.267+1500A>G
INTRON5
Unknown significance
rs796337413
This variant is a VUS because it does not have enough information.
386897
chr16:21694650:C>T
OTOA
NM_144672:c.267+1504C>T
INTRON5
Benign
rs59954465
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
85
1322
0.0643
0
1006
0
4
694
0.0058
0
1008
0
0
978
0
89
5008
0.0177716
386898
chr16:21694673:A>G
OTOA
NM_144672:c.267+1527A>G
INTRON5
Unknown significance
rs545693356
This variant is a VUS because it does not have enough information.
2
1322
0.0015
0
1006
0
0
694
0
0
1008
0
0
978
0
2
5008
0.000399361
386899
chr16:21694688:C>A
OTOA
NM_144672:c.267+1542C>A
INTRON5
Unknown significance
rs184481289
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
1
5008
0.000199681
386900
chr16:21694712:G>A
OTOA
NM_144672:c.267+1566G>A
INTRON5
Benign
rs187369303
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
7
1322
0.0053
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
8
5008
0.00159744
386901
chr16:21694729:T>C
OTOA
NM_144672:c.267+1583T>C
INTRON5
Benign
rs116653572
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
51
1322
0.0386
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
52
5008
0.0103834
386902
chr16:21694776:G>C
OTOA
NM_144672:c.267+1630G>C
INTRON5
Unknown significance
rs755329021
This variant is a VUS because it does not have enough information.
386903
chr16:21694792:T>A
OTOA
NM_144672:c.267+1646T>A
INTRON5
Unknown significance
rs753913918
This variant is a VUS because it does not have enough information.
386904
chr16:21694808:G>A
OTOA
NM_144672:c.267+1662G>A
INTRON5
Unknown significance
rs137980040
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386905
chr16:21694809:T>G
OTOA
NM_144672:c.267+1663T>G
INTRON5
Unknown significance
rs531706338
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386906
chr16:21694815:A>G
OTOA
NM_144672:c.267+1669A>G
INTRON5
Unknown significance
rs142551088
This variant is a VUS because it does not have enough information.
386907
chr16:21694820:C>A
OTOA
NM_144672:c.267+1674C>A
INTRON5
Unknown significance
rs559708721
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386908
chr16:21694821:C>A
OTOA
NM_144672:c.267+1675C>A
INTRON5
Unknown significance
rs571288345
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386909
chr16:21694834:C>G
OTOA
NM_144672:c.267+1688C>G
INTRON5
Unknown significance
rs779476851
This variant is a VUS because it does not have enough information.
386911
chr16:21694839:C>A
OTOA
NM_144672:c.267+1693C>A
INTRON5
Unknown significance
rs74415782
This variant is a VUS because it does not have enough information.
386910
chr16:21694839:C>G
OTOA
NM_144672:c.267+1693C>G
INTRON5
Unknown significance
rs74415782
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386912
chr16:21694840:C>T
OTOA
NM_144672:c.267+1694C>T
INTRON5
Unknown significance
rs62044222
This variant is a VUS because it does not have enough information.
386913
chr16:21694964:T>C
OTOA
NM_144672:c.268-1587T>C
INTRON5
Unknown significance
rs62044223
This variant is a VUS because it does not have enough information.
386914
chr16:21694967:C>T
OTOA
NM_144672:c.268-1584C>T
INTRON5
Unknown significance
rs753249401
This variant is a VUS because it does not have enough information.
386915
chr16:21694968:G>A
OTOA
NM_144672:c.268-1583G>A
INTRON5
Unknown significance
rs62044224
This variant is a VUS because it does not have enough information.
386916
chr16:21694978:G>T
OTOA
NM_144672:c.268-1573G>T
INTRON5
Unknown significance
rs758984163
This variant is a VUS because it does not have enough information.
386917
chr16:21694979:A>C
OTOA
NM_144672:c.268-1572A>C
INTRON5
Unknown significance
rs62044225
This variant is a VUS because it does not have enough information.
386918
chr16:21694986:C>T
OTOA
NM_144672:c.268-1565C>T
INTRON5
Unknown significance
rs62044226
This variant is a VUS because it does not have enough information.
386919
chr16:21694993:T>C
OTOA
NM_144672:c.268-1558T>C
INTRON5
Unknown significance
rs62044227
This variant is a VUS because it does not have enough information.
386920
chr16:21694995:T>C
OTOA
NM_144672:c.268-1556T>C
INTRON5
Unknown significance
rs62044228
This variant is a VUS because it does not have enough information.
386921
chr16:21695021:C>T
OTOA
NM_144672:c.268-1530C>T
INTRON5
Unknown significance
rs62044229
This variant is a VUS because it does not have enough information.
386922
chr16:21695093:A>-
OTOA
NM_144672:c.268-1458delA
INTRON5
Unknown significance
rs780582141
This variant is a VUS because it does not have enough information.
386923
chr16:21695093:AT>-
OTOA
NM_144672:c.268-1458_268-1457delAT
INTRON5
Unknown significance
rs769292336
This variant is a VUS because it does not have enough information.
386924
chr16:21695094:T>-
OTOA
NM_144672:c.268-1457delT
INTRON5
Benign
rs75007819
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
1234
1322
0.9334
869
1006
0.8638
513
694
0.7392
667
1008
0.6617
700
978
0.7157
3983
5008
0.795327
386925
chr16:21695122:C>T
OTOA
NM_144672:c.268-1429C>T
INTRON5
Unknown significance
rs547306583
This variant is a VUS because it does not have enough information.
2
1322
0.0015
0
1006
0
0
694
0
2
1008
0.002
2
978
0.002
6
5008
0.00119808
386926
chr16:21695224:G>A
OTOA
NM_144672:c.268-1327G>A
INTRON5
Unknown significance
rs193027664
This variant is a VUS because it does not have enough information.
3
1322
0.0023
0
1006
0
0
694
0
0
1008
0
0
978
0
3
5008
0.000599042
386927
chr16:21695232:G>C
OTOA
NM_144672:c.268-1319G>C
INTRON5
Unknown significance
rs374135864
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386928
chr16:21695302:C>G
OTOA
NM_144672:c.268-1249C>G
INTRON5
Benign
rs554465392
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
8
1322
0.0061
0
1006
0
0
694
0
0
1008
0
0
978
0
8
5008
0.00159744
386929
chr16:21695330:C>T
OTOA
NM_144672:c.268-1221C>T
INTRON5
Unknown significance
rs542278898
This variant is a VUS because it does not have enough information.
1
1322
0.0008
1
1006
0.001
0
694
0
0
1008
0
0
978
0
2
5008
0.000399361
386930
chr16:21695340:G>T
OTOA
NM_144672:c.268-1211G>T
INTRON5
Unknown significance
rs537128196
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
1
5008
0.000199681
386931
chr16:21695449:->A
OTOA
NM_144672:c.268-1102_268-1101insA
INTRON5
Unknown significance
rs547570023
This variant is a VUS because it does not have enough information.
386933
chr16:21695449:A>T
OTOA
NM_144672:c.268-1102A>T
INTRON5
Benign
rs558612095
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0
1322
0
0
1006
0
0
694
0
0
1008
0
5
978
0.0051
5
5008
0.000998403
386932
chr16:21695449:AA>-
OTOA
NM_144672:c.268-1102_268-1101delAA
INTRON5
Unknown significance
rs80259883
This variant is a VUS because it does not have enough information.
386934
chr16:21695477:G>A
OTOA
NM_144672:c.268-1074G>A
INTRON5
Unknown significance
rs372041012
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
1
978
0.001
2
5008
0.000399361
386935
chr16:21695511:C>T
OTOA
NM_144672:c.268-1040C>T
INTRON5
Unknown significance
rs540990225
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386936
chr16:21695581:T>C
OTOA
NM_144672:c.268-970T>C
INTRON5
Unknown significance
rs544215294
This variant is a VUS because it does not have enough information.
386937
chr16:21695615:A>G
OTOA
NM_144672:c.268-936A>G
INTRON5
Benign
rs554454611
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0
1322
0
0
1006
0
0
694
0
0
1008
0
14
978
0.0143
14
5008
0.00279553
386938
chr16:21695658:A>G
OTOA
NM_144672:c.268-893A>G
INTRON5
Unknown significance
rs139611776
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386939
chr16:21695664:C>A
OTOA
NM_144672:c.268-887C>A
INTRON5
Unknown significance
rs747058537
This variant is a VUS because it does not have enough information.
386940
chr16:21695676:G>A
OTOA
NM_144672:c.268-875G>A
INTRON5
Unknown significance
rs543250192
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386941
chr16:21695707:T>A
OTOA
NM_144672:c.268-844T>A
INTRON5
Unknown significance
rs561310139
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386942
chr16:21695728:G>T
OTOA
NM_144672:c.268-823G>T
INTRON5
Unknown significance
rs576511714
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
1
978
0.001
1
5008
0.000199681
386943
chr16:21695740:G>C
OTOA
NM_144672:c.268-811G>C
INTRON5
Unknown significance
rs543533749
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386944
chr16:21695741:T>G
OTOA
NM_144672:c.268-810T>G
INTRON5
Unknown significance
This variant is a VUS because it does not have enough information.
0
400
0
0
320
0
0
320
0
0
400
0
0
360
0
0
200
0
0
2000
0
386945
chr16:21695752:C>A
OTOA
NM_001161683:c.-92C>A
FIVE_PRIME_EXON
Benign
rs530011814
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0
400
0
0
320
0
0
320
0
0
400
0
4
360
0.0111111
1
200
0.005
5
2000
0.0025
0
1322
0
0
1006
0
0
694
0
0
1008
0
38
978
0.0389
38
5008
0.00758786
386946
chr16:21695760:T>G
OTOA
NM_001161683:c.-84T>G
FIVE_PRIME_EXON
Benign
rs16972655
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
1
3182
0.000314268
45
1384
0.0325145
46
4566
0.0100745
51
1322
0.0386
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
52
5008
0.0103834
386947
chr16:21695781:T>C
OTOA
NM_144672:c.268-770T>C
INTRON5
Benign
rs149333462
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
0
400
0
0
320
0
0
320
0
0
400
0
2
360
0.00555556
0
200
0
2
2000
0.001
13
1322
0.0098
0
1006
0
0
694
0
0
1008
0
0
978
0
13
5008
0.00259585
386948
chr16:21695802:T>C
OTOA
NM_144672:c.268-749T>C
INTRON5
Unknown significance
rs759489392
This variant is a VUS because it does not have enough information.
0
2152
0
0
410
0
0
620
0
0
938
0
1
8692
0.000115048
0
218
0
0
7912
0
1
20942
0.0000477509
386949
chr16:21695869:A>T
OTOA
NM_001161683:p.Asp9Val
NM_001161683:c.26A>T
EXON1
Unknown significance
rs375953749
This variant is a VUS because it does not have enough information.
0.829
N
0.024
D
0.95
P
1
N;N;N
1.82
C
1
3182
0.000314268
0
1384
0
1
4566
0.00021901
386950
chr16:21695871:C>A
OTOA
NM_001161683:p.Gln10Lys
NM_001161683:c.28C>A
EXON1
Likely benign
rs764130349
Pathogenicity is based on prediction data only. 1 out of 5 predictions were pathogenic.
0.655
N
0.066
T
0.001
B
1
N;N;N
0.881
C
0
2146
0
0
408
0
0
616
0
0
324
0
1
8524
0.000117316
0
196
0
0
7912
0
1
20126
0.000049687
386951
chr16:21695871:C>T
OTOA
NM_001161683:p.Gln10Stop
NM_001161683:c.28C>T
EXON1
Unknown significance
rs764130349
This variant is a VUS because it does not have enough information.
0.655
N
1
A;N;N
0.881
C
0
2146
0
0
408
0
0
616
0
0
324
0
1
8524
0.000117316
0
196
0
0
7912
0
1
20126
0.000049687
386952
chr16:21695897:G>A
OTOA
NM_144672:c.268-654G>A
INTRON5
Unknown significance
rs368987029
This variant is a VUS because it does not have enough information.
1
3182
0.000314268
0
1384
0
1
4566
0.00021901
0
2140
0
1
408
0.00245098
0
610
0
0
132
0
1
8438
0.000118511
0
192
0
0
7912
0
2
19832
0.000100847
386953
chr16:21695925:A>G
OTOA
NM_144672:c.268-626A>G
INTRON5
Unknown significance
rs374911630
This variant is a VUS because it does not have enough information.
0
3182
0
2
1384
0.00144509
2
4566
0.00043802
386954
chr16:21695968:G>A
OTOA
NM_144672:c.268-583G>A
INTRON5
Unknown significance
rs559647030
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386955
chr16:21695978:C>T
OTOA
NM_144672:c.268-573C>T
INTRON5
Benign
rs73549616
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
32
1322
0.0242
0
1006
0
0
694
0
0
1008
0
0
978
0
32
5008
0.00638978
386959
chr16:21696041:C>A
OTOA
NM_144672:c.268-510C>A
INTRON5
Unknown significance
rs117580635
This variant is a VUS because it does not have enough information.
1
1322
0.0008
3
1006
0.003
0
694
0
0
1008
0
3
978
0.0031
7
5008
0.00139776
386956
chr16:21696041:CTT>-
OTOA
NM_144672:c.268-510_268-508delCTT
INTRON5
Benign
rs199850780
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
66
1322
0.0499
57
1006
0.0567
52
694
0.0749
5
1008
0.005
42
978
0.0429
222
5008
0.0443291
386957
chr16:21696041:CTTATT>-
OTOA
NM_144672:c.268-510_268-505delCTTATT
INTRON5
Unknown significance
rs752546078
This variant is a VUS because it does not have enough information.
386958
chr16:21696041:CTTATTATT>-
OTOA
NM_144672:c.268-510_268-502delCTTATTATT
INTRON5
Unknown significance
rs763430168
This variant is a VUS because it does not have enough information.
386960
chr16:21696042:TTA>-
OTOA
NM_144672:c.268-509_268-507delTTA
INTRON5
Unknown significance
rs768509228
This variant is a VUS because it does not have enough information.
386961
chr16:21696042:TTATTATTATTATTA>-
OTOA
NM_144672:c.268-509_268-495delTTATTATTATTATTA
INTRON5
Unknown significance
rs531589434
This variant is a VUS because it does not have enough information.
386962
chr16:21696050:A>G
OTOA
NM_144672:c.268-501A>G
INTRON5
Unknown significance
rs569729624
This variant is a VUS because it does not have enough information.
2
1322
0.0015
0
1006
0
0
694
0
0
1008
0
0
978
0
2
5008
0.000399361
386963
chr16:21696060:->TT
OTOA
NM_144672:c.268-491_268-490insTT
INTRON5
Unknown significance
rs776536256
This variant is a VUS because it does not have enough information.
386964
chr16:21696075:TTATTATTATTATTT>-
OTOA
NM_144672:c.268-476_268-462delTTATTATTATTATTT
INTRON5
Unknown significance
rs567726861
This variant is a VUS because it does not have enough information.
386965
chr16:21696078:TTATTATTATTT>-
OTOA
NM_144672:c.268-473_268-462delTTATTATTATTT
INTRON5
Unknown significance
rs200011647
This variant is a VUS because it does not have enough information.
386966
chr16:21696081:TTATTATTT>-
OTOA
NM_144672:c.268-470_268-462delTTATTATTT
INTRON5
Benign
rs68184103
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
788
1322
0.5961
924
1006
0.9185
548
694
0.7896
710
1008
0.7044
851
978
0.8701
3821
5008
0.762979
386967
chr16:21696084:->TTATTT
OTOA
NM_144672:c.268-467_268-466insTTATTT
INTRON5
Unknown significance
rs761681752
This variant is a VUS because it does not have enough information.
386968
chr16:21696084:TTATTT>-
OTOA
NM_144672:c.268-467_268-462delTTATTT
INTRON5
Unknown significance
rs201146251
This variant is a VUS because it does not have enough information.
386969
chr16:21696087:TTT>-
OTOA
NM_144672:c.268-464_268-462delTTT
INTRON5
Unknown significance
rs371843665
This variant is a VUS because it does not have enough information.
386970
chr16:21696089:T>A
OTOA
NM_144672:c.268-462T>A
INTRON5
Unknown significance
rs674917
This variant is a VUS because it does not have enough information.
386971
chr16:21696105:G>A
OTOA
NM_144672:c.268-446G>A
INTRON5
Unknown significance
rs537213727
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
0
1008
0
3
978
0.0031
3
5008
0.000599042
386972
chr16:21696130:T>-
OTOA
NM_144672:c.268-421delT
INTRON5
Unknown significance
rs752416382
This variant is a VUS because it does not have enough information.
386973
chr16:21696133:C>T
OTOA
NM_144672:c.268-418C>T
INTRON5
Benign
rs552315481
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
8
1322
0.0061
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
9
5008
0.00179712
386974
chr16:21696141:C>T
OTOA
NM_144672:c.268-410C>T
INTRON5
Benign
rs112380156
This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005.
17
1322
0.0129
0
1006
0
0
694
0
0
1008
0
0
978
0
17
5008
0.00339457
386975
chr16:21696163:C>T
OTOA
NM_144672:c.268-388C>T
INTRON5
Unknown significance
rs562866941
This variant is a VUS because it does not have enough information.
0
1322
0
2
1006
0.002
0
694
0
0
1008
0
0
978
0
2
5008
0.000399361
386976
chr16:21696218:G>T
OTOA
NM_144672:c.268-333G>T
INTRON5
Unknown significance
rs552688319
This variant is a VUS because it does not have enough information.
0
1322
0
1
1006
0.001
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681
386977
chr16:21696221:C>T
OTOA
NM_144672:c.268-330C>T
INTRON5
Unknown significance
rs572737301
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386978
chr16:21696262:G>C
OTOA
NM_144672:c.268-289G>C
INTRON5
Unknown significance
rs533176024
This variant is a VUS because it does not have enough information.
386979
chr16:21696279:G>A
OTOA
NM_144672:c.268-272G>A
INTRON5
Unknown significance
rs376394764
This variant is a VUS because it does not have enough information.
386980
chr16:21696289:T>C
OTOA
NM_144672:c.268-262T>C
INTRON5
Unknown significance
rs113278726
This variant is a VUS because it does not have enough information.
386981
chr16:21696290:C>T
OTOA
NM_144672:c.268-261C>T
INTRON5
Unknown significance
rs758351068
This variant is a VUS because it does not have enough information.
386982
chr16:21696292:T>A
OTOA
NM_144672:c.268-259T>A
INTRON5
Unknown significance
rs780049479
This variant is a VUS because it does not have enough information.
386983
chr16:21696306:C>T
OTOA
NM_144672:c.268-245C>T
INTRON5
Unknown significance
rs536525929
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386984
chr16:21696316:C>G
OTOA
NM_144672:c.268-235C>G
INTRON5
Unknown significance
rs555219680
This variant is a VUS because it does not have enough information.
2
1322
0.0015
0
1006
0
0
694
0
0
1008
0
0
978
0
2
5008
0.000399361
386985
chr16:21696323:G>A
OTOA
NM_144672:c.268-228G>A
INTRON5
Unknown significance
rs576246211
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386986
chr16:21696363:G>T
OTOA
NM_144672:c.268-188G>T
INTRON5
Unknown significance
rs543571225
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
1
694
0.0014
0
1008
0
0
978
0
1
5008
0.000199681
386987
chr16:21696396:A>G
OTOA
NM_144672:c.268-155A>G
INTRON5
Unknown significance
rs565042807
This variant is a VUS because it does not have enough information.
2
1322
0.0015
0
1006
0
0
694
0
0
1008
0
0
978
0
2
5008
0.000399361
386988
chr16:21696405:T>C
OTOA
NM_144672:c.268-146T>C
INTRON5
Unknown significance
rs746099623
This variant is a VUS because it does not have enough information.
386989
chr16:21696406:T>C
OTOA
NM_144672:c.268-145T>C
INTRON5
Unknown significance
rs190511327
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
0
694
0
1
1008
0.001
0
978
0
1
5008
0.000199681
386990
chr16:21696422:C>A
OTOA
NM_144672:c.268-129C>A
INTRON5
Unknown significance
rs541456162
This variant is a VUS because it does not have enough information.
0
1322
0
0
1006
0
2
694
0.0029
0
1008
0
0
978
0
2
5008
0.000399361
386991
chr16:21696447:C>A
OTOA
NM_144672:c.268-104C>A
INTRON5
Unknown significance
rs192424249
This variant is a VUS because it does not have enough information.
1
1322
0.0008
0
1006
0
0
694
0
0
1008
0
0
978
0
1
5008
0.000199681