854196 chrX:106871660:T>A PRPS1 NM_002764:c.-199T>A FIVE_PRIME_EXON Unknown significance rs750915295 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854197 chrX:106871675:T>G PRPS1 NM_002764:c.-184T>G FIVE_PRIME_EXON Benign This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 400 0 0 320 0 4 320 0.0125 0 400 0 0 360 0 3 200 0.015 7 2000 0.0035 854198 chrX:106871684:C>T PRPS1 NM_002764:c.-175C>T FIVE_PRIME_EXON Unknown significance rs758827912 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854199 chrX:106871692:A>C PRPS1 NM_002764:c.-167A>C FIVE_PRIME_EXON Benign This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 400 0 0 320 0 4 320 0.0125 0 400 0 0 360 0 3 200 0.015 7 2000 0.0035 854200 chrX:106871697:A>C PRPS1 NM_002764:c.-162A>C FIVE_PRIME_EXON Benign This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 400 0 0 320 0 4 320 0.0125 0 400 0 0 360 0 4 200 0.02 8 2000 0.004 854201 chrX:106871706:G>- PRPS1 NM_002764:c.-153delG FIVE_PRIME_EXON Benign rs768856537 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 22 764 0.0288 0 718 0 22 3775 0.00582781 854202 chrX:106871783:G>T PRPS1 NM_002764:c.-76G>T FIVE_PRIME_EXON Unknown significance rs751262798 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854203 chrX:106871786:T>C PRPS1 NM_002764:c.-73T>C FIVE_PRIME_EXON Unknown significance rs199968422 This variant is a VUS because it does not have enough information. 854204 chrX:106871809:T>G PRPS1 NM_002764:c.-50T>G FIVE_PRIME_EXON Unknown significance rs772406932 This variant is a VUS because it does not have enough information. 854205 chrX:106871815:G>- PRPS1 NM_002764:c.-44delG FIVE_PRIME_EXON Unknown significance rs761523210 This variant is a VUS because it does not have enough information. 0 8470 0 0 9324 0 0 6638 0 0 4530 0 0 47842 0 0 632 0 1 10125 0.0000987654 1 87561 0.0000114206 854206 chrX:106871823:G>A PRPS1 NM_002764:c.-36G>A FIVE_PRIME_EXON Unknown significance rs371006312 This variant is a VUS because it does not have enough information. 0 6728 0 1 3835 0.000260756 1 10563 0.0000946701 854207 chrX:106871826:C>A PRPS1 NM_002764:c.-33C>A FIVE_PRIME_EXON Unknown significance rs776399830 This variant is a VUS because it does not have enough information. 0 8486 0 0 9324 0 0 6638 0 0 4530 0 1 47870 0.0000208899 0 632 0 0 10125 0 1 87605 0.0000114149 854208 chrX:106871826:C>T PRPS1 NM_002764:c.-33C>T FIVE_PRIME_EXON Unknown significance rs776399830 This variant is a VUS because it does not have enough information. 0 8486 0 0 9324 0 0 6638 0 0 4530 0 1 47870 0.0000208899 0 632 0 0 10125 0 1 87605 0.0000114149 854209 chrX:106871838:T>G PRPS1 NM_002764:c.-21T>G FIVE_PRIME_EXON Unknown significance This variant is a VUS because it does not have enough information. 0 400 0 0 320 0 0 320 0 0 400 0 0 360 0 0 200 0 0 2000 0 854210 chrX:106871855:C>T PRPS1 NM_002764:c.-4C>T FIVE_PRIME_EXON Unknown significance rs765129709 This variant is a VUS because it does not have enough information. 0 8497 0 0 9324 0 1 6638 0.000150648 0 4530 0 0 47921 0 0 632 0 1 10125 0.0000987654 2 87667 0.0000228136 854211 chrX:106871870:C>T PRPS1 NM_002764:p.Ile4Ile NM_002764:c.12C>T EXON1 Unknown significance rs752590804 This variant is a VUS because it does not have enough information. 0 8504 0 0 9324 0 0 6638 0 0 4530 0 2 47937 0.0000417214 0 632 0 0 10125 0 2 87690 0.0000228076 854212 chrX:106871882:C>T PRPS1 NM_002764:p.Ser8Ser NM_002764:c.24C>T EXON1 Unknown significance rs754682838 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 0 8498 0 0 9324 0 0 6638 0 0 4530 0 0 47918 0 0 632 0 2 10125 0.000197531 2 87665 0.0000228141 854213 chrX:106871888:C>G PRPS1 NM_002764:p.Ser10Arg NM_002764:c.30C>G EXON1 Unknown significance rs763453976 This variant is a VUS because it does not have enough information. -0.328 N 0.067;0.049 T;D 0.03 B 0 D 0.999774 D;D 2.23 C 854214 chrX:106871904:T>C PRPS1 NM_002764:p.Ser16Pro NM_002764:c.46T>C EXON1 Pathogenic Retinitis pigmentosa, syndromic 25491489 Pathogenicity is based on the literature provided in PubMed. 1.061 C 0.002 D 0.835 P 0 D 0.999999 D;D 4.93 C 854215 chrX:106871912:A>G PRPS1 NM_002764:p.Lys18Lys NM_002764:c.54A>G EXON1 Unknown significance rs751085506 This variant is a VUS because it does not have enough information. 0 8505 0 0 9321 0 0 6637 0 0 4530 0 0 47942 0 0 632 0 1 10124 0.0000987752 1 87691 0.0000114037 854216 chrX:106871918:T>C PRPS1 NM_002764:p.Ala20Ala NM_002764:c.60T>C EXON1 Unknown significance rs756853882 This variant is a VUS because it does not have enough information. 0 8504 0 0 9321 0 0 6637 0 0 4530 0 2 47941 0.0000417179 0 631 0 0 10123 0 2 87687 0.0000228084 854217 chrX:106871947:T>G PRPS1 NM_002764:p.Val30Gly NM_002764:c.89T>G EXON1 Unknown significance This variant is a VUS because it does not have enough information. 1.061 C 0.0 D 0.689 P 0 D 1 D;D 4.93 C 0 400 0 0 320 0 0 320 0 0 400 0 0 360 0 0 200 0 0 2000 0 854218 chrX:106871950:T>G PRPS1 NM_002764:p.Val31Gly NM_002764:c.92T>G EXON1 Unknown significance This variant is a VUS because it does not have enough information. 1.061 C 0.417;0.411 T 0.086 B 0 D 1 D;D 4.93 C 0 400 0 0 320 0 0 320 0 0 400 0 0 360 0 0 200 0 0 2000 0 854219 chrX:106871965:G>C PRPS1 NM_002764:p.Ser36Thr NM_002764:c.107G>C EXON1 Unknown significance rs780954680 This variant is a VUS because it does not have enough information. 1.048 C 0.053;0.048 T;D 0.0 B 0 D 0.999999 D;D 4.93 C 0 8487 0 0 9309 0 0 6631 0 0 4522 0 1 47824 0.00002091 0 629 0 0 10078 0 1 87480 0.0000114312 854220 chrX:106871981:->TGTGGAAATTGGTGAAAGTGTACGTGGAGAGGATGTCTACATT PRPS1 NM_002764:c.122+1_122+2insTGTGGAAATTGGTGAAAGTGTACGTGGAGAGGATGTCTACATT INTRON1 Unknown significance rs767417913 This variant is a VUS because it does not have enough information. 854221 chrX:106871993:T>C PRPS1 NM_002764:c.122+13T>C INTRON1 Unknown significance rs750791916 This variant is a VUS because it does not have enough information. 0 8442 0 0 9235 0 0 6588 0 0 4488 0 1 47352 0.0000211184 0 623 0 0 9979 0 1 86707 0.0000115331 854222 chrX:106871996:G>A PRPS1 NM_002764:c.122+16G>A INTRON1 Unknown significance rs756583830 This variant is a VUS because it does not have enough information. 854223 chrX:106872004:A>G PRPS1 NM_002764:c.122+24A>G INTRON1 Unknown significance rs375500956 This variant is a VUS because it does not have enough information. 1 6728 0.000148633 0 3835 0 1 10563 0.0000946701 0 8377 0 0 9189 0 0 6552 0 0 4473 0 1 46944 0.000021302 0 616 0 0 9947 0 1 86098 0.0000116147 854224 chrX:106872010:C>T PRPS1 NM_002764:c.122+30C>T INTRON1 Unknown significance rs367842963 This variant is a VUS because it does not have enough information. 0 8321 0 0 9174 0 0 6535 0 0 4463 0 0 46653 0 0 614 0 1 9925 0.000100756 1 85685 0.0000116707 854225 chrX:106872017:T>G PRPS1 NM_002764:c.122+37T>G INTRON1 Benign rs193273254 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 2 6727 0.000297309 1 3835 0.000260756 3 10562 0.000284037 0 1003 0 0 766 0 20 524 0.0382 9 764 0.0118 0 718 0 29 3775 0.00768212 0 8270 0 341 9122 0.0373822 103 6483 0.0158877 6 4446 0.00134953 19 46277 0.000410571 4 611 0.00654664 4 9891 0.000404408 477 85100 0.00560517 854226 chrX:106872018:G>A PRPS1 NM_002764:c.122+38G>A INTRON1 Unknown significance rs778859413 This variant is a VUS because it does not have enough information. 0 8238 0 0 9127 0 0 6471 0 0 4434 0 1 46135 0.0000216755 0 609 0 0 9885 0 1 84899 0.0000117787 854227 chrX:106872026:G>A PRPS1 NM_002764:c.122+46G>A INTRON1 Unknown significance rs748321395 This variant is a VUS because it does not have enough information. 0 8188 0 0 9063 0 0 6409 0 1 4408 0.00022686 0 45698 0 0 607 0 2 9806 0.000203957 3 84179 0.0000356383 854228 chrX:106872036:A>G PRPS1 NM_002764:c.122+56A>G INTRON1 Unknown significance rs747701318 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 0 718 0 1 3775 0.000264901 854229 chrX:106872140:C>T PRPS1 NM_002764:c.122+160C>T INTRON1 Unknown significance rs755523346 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854230 chrX:106872178:G>- PRPS1 NM_002764:c.122+198delG INTRON1 Unknown significance rs749410565 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854231 chrX:106872194:A>G PRPS1 NM_002764:c.122+214A>G INTRON1 Unknown significance rs771636792 This variant is a VUS because it does not have enough information. 854232 chrX:106872234:C>T PRPS1 NM_002764:c.122+254C>T INTRON1 Benign rs138384709 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 32 1003 0.0319 1 766 0.0013 0 524 0 0 764 0 0 718 0 33 3775 0.00874172 854233 chrX:106872268:G>A PRPS1 NM_002764:c.122+288G>A INTRON1 Unknown significance rs185415093 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854234 chrX:106872270:C>A PRPS1 NM_002764:c.122+290C>A INTRON1 Unknown significance rs773293666 This variant is a VUS because it does not have enough information. 854235 chrX:106872275:G>- PRPS1 NM_002764:c.122+295delG INTRON1 Unknown significance rs778869012 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 0 718 0 1 3775 0.000264901 854236 chrX:106872308:C>G PRPS1 NM_002764:c.122+328C>G INTRON1 Unknown significance rs760477411 This variant is a VUS because it does not have enough information. 854237 chrX:106872343:G>A PRPS1 NM_002764:c.122+363G>A INTRON1 Unknown significance rs766240300 This variant is a VUS because it does not have enough information. 854238 chrX:106872348:G>A PRPS1 NM_002764:c.122+368G>A INTRON1 Unknown significance rs745615704 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854239 chrX:106872389:A>G PRPS1 NM_002764:c.122+409A>G INTRON1 Unknown significance rs768924705 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 1 764 0.0013 0 718 0 2 3775 0.000529801 854240 chrX:106872395:G>T PRPS1 NM_002764:c.122+415G>T INTRON1 Unknown significance rs753555561 This variant is a VUS because it does not have enough information. 854241 chrX:106872399:T>C PRPS1 NM_002764:c.122+419T>C INTRON1 Unknown significance rs374765543 This variant is a VUS because it does not have enough information. 854242 chrX:106872433:A>G PRPS1 NM_002764:c.122+453A>G INTRON1 Benign rs142874509 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 1 1003 0.001 7 766 0.0091 3 524 0.0057 0 764 0 2 718 0.0028 13 3775 0.00344371 854243 chrX:106872575:C>A PRPS1 NM_002764:c.122+595C>A INTRON1 Benign rs146084272 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 1 766 0.0013 0 524 0 4 764 0.0052 4 718 0.0056 9 3775 0.00238411 854244 chrX:106872588:T>C PRPS1 NM_002764:c.122+608T>C INTRON1 Unknown significance rs769758337 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854245 chrX:106872613:T>G PRPS1 NM_002764:c.122+633T>G INTRON1 Unknown significance rs189414406 This variant is a VUS because it does not have enough information. 3 1003 0.003 0 766 0 0 524 0 0 764 0 0 718 0 3 3775 0.000794702 854246 chrX:106872651:C>T PRPS1 NM_002764:c.122+671C>T INTRON1 Unknown significance rs765444382 This variant is a VUS because it does not have enough information. 854247 chrX:106872652:A>G PRPS1 NM_002764:c.122+672A>G INTRON1 Unknown significance rs752850344 This variant is a VUS because it does not have enough information. 854248 chrX:106872792:A>- PRPS1 NM_002764:c.122+812delA INTRON1 Unknown significance rs35200070 This variant is a VUS because it does not have enough information. 854249 chrX:106872809:T>C PRPS1 NM_002764:c.122+829T>C INTRON1 Unknown significance rs758486202 This variant is a VUS because it does not have enough information. 854250 chrX:106872817:A>T PRPS1 NM_002764:c.122+837A>T INTRON1 Unknown significance rs180981877 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854251 chrX:106872877:A>G PRPS1 NM_002764:c.122+897A>G INTRON1 Unknown significance rs766823778 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854252 chrX:106872897:->G PRPS1 NM_002764:c.122+917_122+918insG INTRON1 Unknown significance rs35044412 This variant is a VUS because it does not have enough information. 854253 chrX:106873144:AATC>- PRPS1 NM_002764:c.122+1164_122+1167delAATC INTRON1 Unknown significance rs759095342 This variant is a VUS because it does not have enough information. 854254 chrX:106873167:A>- PRPS1 NM_002764:c.122+1187delA INTRON1 Unknown significance rs751954344 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854255 chrX:106873292:C>T PRPS1 NM_002764:c.122+1312C>T INTRON1 Unknown significance rs759753528 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854256 chrX:106873305:T>C PRPS1 NM_002764:c.122+1325T>C INTRON1 Unknown significance rs183775374 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 2 524 0.0038 0 764 0 0 718 0 2 3775 0.000529801 854257 chrX:106873343:T>A PRPS1 NM_002764:c.122+1363T>A INTRON1 Unknown significance rs752281052 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854258 chrX:106873413:A>G PRPS1 NM_002764:c.122+1433A>G INTRON1 Unknown significance rs796366037 This variant is a VUS because it does not have enough information. 854259 chrX:106873464:T>C PRPS1 NM_002764:c.122+1484T>C INTRON1 Benign rs10521515 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 32 1003 0.0319 1 766 0.0013 0 524 0 0 764 0 0 718 0 33 3775 0.00874172 854260 chrX:106873635:G>A PRPS1 NM_002764:c.122+1655G>A INTRON1 Benign rs73522885 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 219 1003 0.2183 1 766 0.0013 16 524 0.0305 0 764 0 0 718 0 236 3775 0.0625166 854261 chrX:106873643:A>G PRPS1 NM_002764:c.122+1663A>G INTRON1 Unknown significance rs757672970 This variant is a VUS because it does not have enough information. 854262 chrX:106873647:G>C PRPS1 NM_002764:c.122+1667G>C INTRON1 Unknown significance rs552527422 This variant is a VUS because it does not have enough information. 854263 chrX:106873750:T>A PRPS1 NM_002764:c.122+1770T>A INTRON1 Unknown significance rs188846804 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 2 524 0.0038 0 764 0 0 718 0 2 3775 0.000529801 854264 chrX:106873804:->T PRPS1 NM_002764:c.122+1824_122+1825insT INTRON1 Unknown significance rs200870825 This variant is a VUS because it does not have enough information. 854265 chrX:106873819:T>C PRPS1 NM_002764:c.122+1839T>C INTRON1 Unknown significance rs181131365 This variant is a VUS because it does not have enough information. 2 1003 0.002 0 766 0 0 524 0 0 764 0 0 718 0 2 3775 0.000529801 854266 chrX:106873821:C>A PRPS1 NM_002764:c.122+1841C>A INTRON1 Unknown significance rs186982435 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 0 718 0 1 3775 0.000264901 854267 chrX:106873821:C>T PRPS1 NM_002764:c.122+1841C>T INTRON1 Unknown significance rs186982435 This variant is a VUS because it does not have enough information. 854268 chrX:106873886:T>G PRPS1 NM_002764:c.122+1906T>G INTRON1 Unknown significance rs781655355 This variant is a VUS because it does not have enough information. 854269 chrX:106873891:C>T PRPS1 NM_002764:c.122+1911C>T INTRON1 Unknown significance rs745688321 This variant is a VUS because it does not have enough information. 3 1003 0.003 0 766 0 0 524 0 0 764 0 0 718 0 3 3775 0.000794702 854270 chrX:106873940:T>A PRPS1 NM_002764:c.122+1960T>A INTRON1 Unknown significance rs771748172 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854271 chrX:106873969:->AC PRPS1 NM_002764:c.122+1989_122+1990insAC INTRON1 Benign rs111543861 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 360 1003 0.3589 72 766 0.094 63 524 0.1202 61 764 0.0798 81 718 0.1128 637 3775 0.168742 854272 chrX:106873969:->ACAC PRPS1 NM_002764:c.122+1989_122+1990insACAC INTRON1 Unknown significance rs111543861 This variant is a VUS because it does not have enough information. 854273 chrX:106873969:AC>- PRPS1 NM_002764:c.122+1989_122+1990delAC INTRON1 Unknown significance rs371707973 This variant is a VUS because it does not have enough information. 854274 chrX:106874039:G>A PRPS1 NM_002764:c.122+2059G>A INTRON1 Unknown significance rs191474853 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 2 764 0.0026 0 718 0 2 3775 0.000529801 854275 chrX:106874103:->C PRPS1 NM_002764:c.122+2123_122+2124insC INTRON1 Unknown significance rs36067824 This variant is a VUS because it does not have enough information. 854276 chrX:106874167:ATA>- PRPS1 NM_002764:c.122+2187_122+2189delATA INTRON1 Unknown significance rs760134364 This variant is a VUS because it does not have enough information. 854277 chrX:106874202:G>A PRPS1 NM_002764:c.122+2222G>A INTRON1 Unknown significance rs746204757 This variant is a VUS because it does not have enough information. 854278 chrX:106874243:G>A PRPS1 NM_002764:c.122+2263G>A INTRON1 Unknown significance rs754743556 This variant is a VUS because it does not have enough information. 854279 chrX:106874314:G>A PRPS1 NM_002764:c.122+2334G>A INTRON1 Unknown significance rs769966211 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854280 chrX:106874318:T>C PRPS1 NM_002764:c.122+2338T>C INTRON1 Unknown significance rs773302921 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854281 chrX:106874334:T>- PRPS1 NM_002764:c.122+2354delT INTRON1 Unknown significance rs34555392 This variant is a VUS because it does not have enough information. 854282 chrX:106874351:A>G PRPS1 NM_002764:c.122+2371A>G INTRON1 Unknown significance rs182452681 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854283 chrX:106874478:T>A PRPS1 NM_002764:c.122+2498T>A INTRON1 Unknown significance rs778709371 This variant is a VUS because it does not have enough information. 854284 chrX:106874479:A>G PRPS1 NM_002764:c.122+2499A>G INTRON1 Unknown significance rs747741622 This variant is a VUS because it does not have enough information. 854285 chrX:106874494:G>C PRPS1 NM_002764:c.122+2514G>C INTRON1 Unknown significance rs186379973 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854286 chrX:106874496:G>A PRPS1 NM_002764:c.122+2516G>A INTRON1 Unknown significance rs771728429 This variant is a VUS because it does not have enough information. 854287 chrX:106874547:G>A PRPS1 NM_002764:c.122+2567G>A INTRON1 Unknown significance rs570999604 This variant is a VUS because it does not have enough information. 854288 chrX:106874548:C>T PRPS1 NM_002764:c.122+2568C>T INTRON1 Unknown significance rs772806190 This variant is a VUS because it does not have enough information. 854289 chrX:106874589:G>A PRPS1 NM_002764:c.122+2609G>A INTRON1 Unknown significance rs774784583 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854290 chrX:106874630:A>G PRPS1 NM_002764:c.122+2650A>G INTRON1 Unknown significance rs747019743 This variant is a VUS because it does not have enough information. 854291 chrX:106874682:A>C PRPS1 NM_002764:c.122+2702A>C INTRON1 Unknown significance rs770762937 This variant is a VUS because it does not have enough information. 854292 chrX:106874862:C>T PRPS1 NM_002764:c.122+2882C>T INTRON1 Benign rs760006234 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 9 718 0.0125 9 3775 0.00238411 854293 chrX:106874942:C>T PRPS1 NM_002764:c.122+2962C>T INTRON1 Unknown significance rs776561387 This variant is a VUS because it does not have enough information. 854294 chrX:106874974:T>A PRPS1 NM_002764:c.122+2994T>A INTRON1 Benign rs190873476 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 32 1003 0.0319 1 766 0.0013 0 524 0 0 764 0 0 718 0 33 3775 0.00874172 854295 chrX:106875002:C>T PRPS1 NM_002764:c.122+3022C>T INTRON1 Unknown significance rs372450890 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 1 764 0.0013 0 718 0 2 3775 0.000529801 854296 chrX:106875073:C>T PRPS1 NM_002764:c.122+3093C>T INTRON1 Unknown significance rs200476611 This variant is a VUS because it does not have enough information. 854297 chrX:106875091:T>A PRPS1 NM_002764:c.122+3111T>A INTRON1 Unknown significance rs111613490 This variant is a VUS because it does not have enough information. 854298 chrX:106875209:G>A PRPS1 NM_002764:c.122+3229G>A INTRON1 Unknown significance rs760264647 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854299 chrX:106875213:C>T PRPS1 NM_002764:c.122+3233C>T INTRON1 Unknown significance rs764954665 This variant is a VUS because it does not have enough information. 854300 chrX:106875229:A>G PRPS1 NM_002764:c.122+3249A>G INTRON1 Unknown significance rs763795780 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 0 718 0 1 3775 0.000264901 854301 chrX:106875324:T>C PRPS1 NM_002764:c.122+3344T>C INTRON1 Benign rs144193551 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 31 1003 0.0309 0 766 0 1 524 0.0019 0 764 0 0 718 0 32 3775 0.00847682 854302 chrX:106875353:C>T PRPS1 NM_002764:c.122+3373C>T INTRON1 Unknown significance rs756765672 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854303 chrX:106875589:G>A PRPS1 NM_002764:c.122+3609G>A INTRON1 Unknown significance rs779050605 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 3 718 0.0042 3 3775 0.000794702 854304 chrX:106875615:C>T PRPS1 NM_002764:c.122+3635C>T INTRON1 Unknown significance rs182334827 This variant is a VUS because it does not have enough information. 2 1003 0.002 0 766 0 2 524 0.0038 0 764 0 0 718 0 4 3775 0.0010596 854305 chrX:106875621:A>G PRPS1 NM_002764:c.122+3641A>G INTRON1 Unknown significance rs758252130 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854306 chrX:106875626:C>T PRPS1 NM_002764:c.122+3646C>T INTRON1 Unknown significance rs763123265 This variant is a VUS because it does not have enough information. 854307 chrX:106875712:A>G PRPS1 NM_002764:c.122+3732A>G INTRON1 Unknown significance rs764196639 This variant is a VUS because it does not have enough information. 854308 chrX:106875720:C>T PRPS1 NM_002764:c.122+3740C>T INTRON1 Benign rs148691098 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 6 766 0.0078 1 524 0.0019 0 764 0 4 718 0.0056 11 3775 0.00291391 854309 chrX:106875741:G>C PRPS1 NM_002764:c.122+3761G>C INTRON1 Unknown significance rs746769872 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854310 chrX:106875759:T>A PRPS1 NM_002764:c.122+3779T>A INTRON1 Unknown significance rs756360348 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 2 718 0.0028 2 3775 0.000529801 854311 chrX:106875797:T>C PRPS1 NM_002764:c.122+3817T>C INTRON1 Unknown significance rs757839327 This variant is a VUS because it does not have enough information. 854312 chrX:106875867:G>T PRPS1 NM_002764:c.122+3887G>T INTRON1 Benign rs10217967 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 231 1003 0.2303 1 766 0.0013 9 524 0.0172 3 764 0.0039 6 718 0.0084 250 3775 0.0662252 854313 chrX:106875940:A>G PRPS1 NM_002764:c.122+3960A>G INTRON1 Unknown significance rs750872392 This variant is a VUS because it does not have enough information. 854314 chrX:106876014:T>G PRPS1 NM_002764:c.122+4034T>G INTRON1 Unknown significance rs756557143 This variant is a VUS because it does not have enough information. 854315 chrX:106876047:C>T PRPS1 NM_002764:c.122+4067C>T INTRON1 Unknown significance rs186482273 This variant is a VUS because it does not have enough information. 854316 chrX:106876171:A>G PRPS1 NM_002764:c.122+4191A>G INTRON1 Unknown significance rs749385243 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854317 chrX:106876188:C>T PRPS1 NM_002764:c.122+4208C>T INTRON1 Unknown significance rs532784341 This variant is a VUS because it does not have enough information. 854318 chrX:106876248:G>C PRPS1 NM_002764:c.122+4268G>C INTRON1 Benign rs73522887 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 257 1003 0.2562 3 766 0.0039 60 524 0.1145 34 764 0.0445 39 718 0.0543 393 3775 0.104106 854319 chrX:106876272:A>G PRPS1 NM_002764:c.122+4292A>G INTRON1 Unknown significance rs191421495 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854320 chrX:106876273:T>A PRPS1 NM_002764:c.122+4293T>A INTRON1 Unknown significance rs746333368 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854321 chrX:106876314:A>T PRPS1 NM_002764:c.122+4334A>T INTRON1 Benign rs182847765 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 8 764 0.0105 0 718 0 8 3775 0.00211921 854322 chrX:106876331:C>T PRPS1 NM_002764:c.122+4351C>T INTRON1 Unknown significance rs188712487 This variant is a VUS because it does not have enough information. 2 1003 0.002 0 766 0 1 524 0.0019 0 764 0 0 718 0 3 3775 0.000794702 854323 chrX:106876349:G>T PRPS1 NM_002764:c.122+4369G>T INTRON1 Unknown significance rs192975637 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 0 718 0 1 3775 0.000264901 854324 chrX:106876375:G>A PRPS1 NM_002764:c.122+4395G>A INTRON1 Unknown significance rs185204310 This variant is a VUS because it does not have enough information. 0 1003 0 2 766 0.0026 0 524 0 0 764 0 1 718 0.0014 3 3775 0.000794702 854325 chrX:106876381:G>A PRPS1 NM_002764:c.122+4401G>A INTRON1 Benign rs7884442 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 257 1003 0.2562 3 766 0.0039 60 524 0.1145 34 764 0.0445 39 718 0.0543 393 3775 0.104106 854326 chrX:106876497:->A PRPS1 NM_002764:c.122+4517_122+4518insA INTRON1 Unknown significance rs764603309 This variant is a VUS because it does not have enough information. 854327 chrX:106876511:G>A PRPS1 NM_002764:c.122+4531G>A INTRON1 Unknown significance rs761480846 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 1 524 0.0019 0 764 0 0 718 0 2 3775 0.000529801 854328 chrX:106876525:G>A PRPS1 NM_002764:c.122+4545G>A INTRON1 Unknown significance rs764808225 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 1 718 0.0014 2 3775 0.000529801 854329 chrX:106876525:G>T PRPS1 NM_002764:c.122+4545G>T INTRON1 Unknown significance rs764808225 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 2 764 0.0026 0 718 0 2 3775 0.000529801 854330 chrX:106876596:G>A PRPS1 NM_002764:c.122+4616G>A INTRON1 Benign rs758290517 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 1 1003 0.001 7 766 0.0091 4 524 0.0076 0 764 0 5 718 0.007 17 3775 0.00450331 854331 chrX:106876615:G>A PRPS1 NM_002764:c.122+4635G>A INTRON1 Benign rs145160619 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 64 524 0.1221 0 764 0 0 718 0 64 3775 0.0169536 854332 chrX:106876734:G>A PRPS1 NM_002764:c.122+4754G>A INTRON1 Unknown significance rs188088931 This variant is a VUS because it does not have enough information. 854333 chrX:106876860:A>T PRPS1 NM_002764:c.122+4880A>T INTRON1 Benign rs751317330 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 9 1003 0.009 0 766 0 2 524 0.0038 0 764 0 0 718 0 11 3775 0.00291391 854334 chrX:106877017:C>T PRPS1 NM_002764:c.122+5037C>T INTRON1 Benign rs537971156 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 12 718 0.0167 12 3775 0.00317881 854335 chrX:106877055:G>A PRPS1 NM_002764:c.122+5075G>A INTRON1 Unknown significance rs770411841 This variant is a VUS because it does not have enough information. 854336 chrX:106877093:G>A PRPS1 NM_002764:c.122+5113G>A INTRON1 Unknown significance rs776447158 This variant is a VUS because it does not have enough information. 854337 chrX:106877152:G>A PRPS1 NM_002764:c.122+5172G>A INTRON1 Benign rs778029393 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 10 718 0.0139 10 3775 0.00264901 854338 chrX:106877308:G>A PRPS1 NM_002764:c.123-5217G>A INTRON1 Unknown significance rs369171236 This variant is a VUS because it does not have enough information. 854339 chrX:106877331:T>A PRPS1 NM_002764:c.123-5194T>A INTRON1 Unknown significance rs749511614 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 0 718 0 0 3775 0 854340 chrX:106877445:T>G PRPS1 NM_002764:c.123-5080T>G INTRON1 Unknown significance rs757371182 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854341 chrX:106877491:C>A PRPS1 NM_002764:c.123-5034C>A INTRON1 Unknown significance rs112037796 This variant is a VUS because it does not have enough information. 854342 chrX:106877506:G>A PRPS1 NM_002764:c.123-5019G>A INTRON1 Unknown significance rs745757185 This variant is a VUS because it does not have enough information. 854343 chrX:106877526:G>A PRPS1 NM_002764:c.123-4999G>A INTRON1 Unknown significance rs778841095 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854344 chrX:106877545:C>T PRPS1 NM_002764:c.123-4980C>T INTRON1 Unknown significance rs775236243 This variant is a VUS because it does not have enough information. 854345 chrX:106877547:C>T PRPS1 NM_002764:c.123-4978C>T INTRON1 Unknown significance rs763209177 This variant is a VUS because it does not have enough information. 854346 chrX:106877589:C>T PRPS1 NM_002764:c.123-4936C>T INTRON1 Benign rs550209701 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 15 718 0.0209 15 3775 0.00397351 854347 chrX:106877651:C>T PRPS1 NM_002764:c.123-4874C>T INTRON1 Benign rs113906370 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 5 1003 0.005 0 766 0 0 524 0 0 764 0 0 718 0 5 3775 0.0013245 854348 chrX:106877750:A>C PRPS1 NM_002764:c.123-4775A>C INTRON1 Unknown significance rs59623574 This variant is a VUS because it does not have enough information. 854349 chrX:106877863:T>C PRPS1 NM_002764:c.123-4662T>C INTRON1 Unknown significance rs112717844 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854350 chrX:106877904:A>T PRPS1 NM_002764:c.123-4621A>T INTRON1 Unknown significance rs764286284 This variant is a VUS because it does not have enough information. 854351 chrX:106877944:A>G PRPS1 NM_002764:c.123-4581A>G INTRON1 Unknown significance rs183830604 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854352 chrX:106877955:G>A PRPS1 NM_002764:c.123-4570G>A INTRON1 Unknown significance rs769136248 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854353 chrX:106878001:->AGAT PRPS1 NM_002764:c.123-4524_123-4523insAGAT INTRON1 Benign rs776461951 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 12 718 0.0167 12 3775 0.00317881 854354 chrX:106878065:G>T PRPS1 NM_002764:c.123-4460G>T INTRON1 Unknown significance rs111806334 This variant is a VUS because it does not have enough information. 854355 chrX:106878066:->T PRPS1 NM_002764:c.123-4459_123-4458insT INTRON1 Unknown significance rs781010422 This variant is a VUS because it does not have enough information. 854356 chrX:106878070:T>G PRPS1 NM_002764:c.123-4455T>G INTRON1 Unknown significance rs761534167 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854357 chrX:106878138:C>T PRPS1 NM_002764:c.123-4387C>T INTRON1 Unknown significance rs764933023 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854358 chrX:106878178:C>T PRPS1 NM_002764:c.123-4347C>T INTRON1 Unknown significance rs372725144 This variant is a VUS because it does not have enough information. 854359 chrX:106878237:->T PRPS1 NM_002764:c.123-4288_123-4287insT INTRON1 Unknown significance rs772628145 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854360 chrX:106878245:T>C PRPS1 NM_002764:c.123-4280T>C INTRON1 Unknown significance rs762458667 This variant is a VUS because it does not have enough information. 0 1003 0 2 766 0.0026 1 524 0.0019 0 764 0 1 718 0.0014 4 3775 0.0010596 854361 chrX:106878272:C>T PRPS1 NM_002764:c.123-4253C>T INTRON1 Unknown significance rs766241716 This variant is a VUS because it does not have enough information. 2 1003 0.002 1 766 0.0013 1 524 0.0019 0 764 0 0 718 0 4 3775 0.0010596 854362 chrX:106878307:G>A PRPS1 NM_002764:c.123-4218G>A INTRON1 Unknown significance rs751502881 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854363 chrX:106878314:G>C PRPS1 NM_002764:c.123-4211G>C INTRON1 Unknown significance rs746052519 This variant is a VUS because it does not have enough information. 854364 chrX:106878318:G>A PRPS1 NM_002764:c.123-4207G>A INTRON1 Unknown significance rs754836548 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854365 chrX:106878322:C>T PRPS1 NM_002764:c.123-4203C>T INTRON1 Unknown significance rs377248917 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 1 524 0.0019 0 764 0 0 718 0 2 3775 0.000529801 854366 chrX:106878334:G>A PRPS1 NM_002764:c.123-4191G>A INTRON1 Unknown significance rs754112314 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854367 chrX:106878351:G>A PRPS1 NM_002764:c.123-4174G>A INTRON1 Benign rs188101417 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 60 1003 0.0598 1 766 0.0013 2 524 0.0038 0 764 0 0 718 0 63 3775 0.0166887 854368 chrX:106878354:AGCCACCGTGCCCAGCGATA>- PRPS1 NM_002764:c.123-4171_123-4152delAGCCACCGTGCCCAGCGATA INTRON1 Benign rs201578496 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 20 1003 0.0199 2 766 0.0026 19 524 0.0363 45 764 0.0589 5 718 0.007 91 3775 0.024106 854369 chrX:106878356:C>T PRPS1 NM_002764:c.123-4169C>T INTRON1 Unknown significance rs750479526 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854370 chrX:106878369:C>T PRPS1 NM_002764:c.123-4156C>T INTRON1 Unknown significance rs758489477 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854371 chrX:106878428:T>C PRPS1 NM_002764:c.123-4097T>C INTRON1 Unknown significance rs181484489 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854372 chrX:106878507:G>A PRPS1 NM_002764:c.123-4018G>A INTRON1 Unknown significance rs750912126 This variant is a VUS because it does not have enough information. 854373 chrX:106878518:A>T PRPS1 NM_002764:c.123-4007A>T INTRON1 Unknown significance rs374991635 This variant is a VUS because it does not have enough information. 854374 chrX:106878571:A>C PRPS1 NM_002764:c.123-3954A>C INTRON1 Unknown significance rs150953574 This variant is a VUS because it does not have enough information. 3 1003 0.003 0 766 0 0 524 0 0 764 0 0 718 0 3 3775 0.000794702 854375 chrX:106878625:C>T PRPS1 NM_002764:c.123-3900C>T INTRON1 Benign rs73522890 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 219 1003 0.2183 1 766 0.0013 16 524 0.0305 0 764 0 0 718 0 236 3775 0.0625166 854376 chrX:106878639:A>G PRPS1 NM_002764:c.123-3886A>G INTRON1 Benign rs5962868 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 22 1003 0.0219 0 766 0 2 524 0.0038 0 764 0 0 718 0 24 3775 0.00635762 854377 chrX:106878676:->T PRPS1 NM_002764:c.123-3849_123-3848insT INTRON1 Benign rs748484157 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 222 1003 0.2213 19 766 0.0248 68 524 0.1298 48 764 0.0628 70 718 0.0975 427 3775 0.113113 854378 chrX:106878676:->TT PRPS1 NM_002764:c.123-3849_123-3848insTT INTRON1 Benign rs748484157 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 218 1003 0.2173 1 766 0.0013 10 524 0.0191 3 764 0.0039 4 718 0.0056 236 3775 0.0625166 854379 chrX:106878676:->TTTT PRPS1 NM_002764:c.123-3849_123-3848insTTTT INTRON1 Unknown significance rs748484157 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854380 chrX:106878676:T>- PRPS1 NM_002764:c.123-3849delT INTRON1 Unknown significance rs769800664 This variant is a VUS because it does not have enough information. 854381 chrX:106878704:C>G PRPS1 NM_002764:c.123-3821C>G INTRON1 Benign rs189754915 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 4 766 0.0052 0 524 0 0 764 0 0 718 0 4 3775 0.0010596 854382 chrX:106878706:C>G PRPS1 NM_002764:c.123-3819C>G INTRON1 Benign rs149666552 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 64 1003 0.0638 1 766 0.0013 2 524 0.0038 0 764 0 0 718 0 67 3775 0.0177483 854383 chrX:106878785:C>T PRPS1 NM_002764:c.123-3740C>T INTRON1 Unknown significance rs369420289 This variant is a VUS because it does not have enough information. 854384 chrX:106878798:A>G PRPS1 NM_002764:c.123-3727A>G INTRON1 Unknown significance rs754244641 This variant is a VUS because it does not have enough information. 854385 chrX:106878823:A>G PRPS1 NM_002764:c.123-3702A>G INTRON1 Benign rs73249852 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 20 1003 0.0199 221 766 0.2885 67 524 0.1279 39 764 0.051 43 718 0.0599 390 3775 0.103311 854386 chrX:106878882:C>T PRPS1 NM_002764:c.123-3643C>T INTRON1 Unknown significance rs775692710 This variant is a VUS because it does not have enough information. 854387 chrX:106878891:T>C PRPS1 NM_002764:c.123-3634T>C INTRON1 Unknown significance rs759451608 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854388 chrX:106878897:G>A PRPS1 NM_002764:c.123-3628G>A INTRON1 Unknown significance rs777299439 This variant is a VUS because it does not have enough information. 854389 chrX:106878944:C>T PRPS1 NM_002764:c.123-3581C>T INTRON1 Unknown significance rs181894823 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854390 chrX:106879025:T>A PRPS1 NM_002764:c.123-3500T>A INTRON1 Unknown significance rs752488676 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 1 718 0.0014 2 3775 0.000529801 854391 chrX:106879026:C>A PRPS1 NM_002764:c.123-3499C>A INTRON1 Unknown significance rs760400412 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 1 718 0.0014 2 3775 0.000529801 854392 chrX:106879045:C>T PRPS1 NM_002764:c.123-3480C>T INTRON1 Unknown significance rs765431742 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 1 718 0.0014 2 3775 0.000529801 854393 chrX:106879072:C>T PRPS1 NM_002764:c.123-3453C>T INTRON1 Benign rs373175062 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 11 1003 0.011 0 766 0 0 524 0 0 764 0 0 718 0 11 3775 0.00291391 854394 chrX:106879105:A>G PRPS1 NM_002764:c.123-3420A>G INTRON1 Unknown significance rs185828952 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 0 718 0 1 3775 0.000264901 854395 chrX:106879114:C>- PRPS1 NM_002764:c.123-3411delC INTRON1 Benign rs200264830 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 228 1003 0.2273 1 766 0.0013 9 524 0.0172 3 764 0.0039 6 718 0.0084 247 3775 0.0654305 854396 chrX:106879204:C>T PRPS1 NM_002764:c.123-3321C>T INTRON1 Benign rs190926438 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 29 766 0.0379 7 524 0.0134 0 764 0 6 718 0.0084 42 3775 0.0111258 854397 chrX:106879215:G>A PRPS1 NM_002764:c.123-3310G>A INTRON1 Unknown significance rs755573363 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854398 chrX:106879221:T>G PRPS1 NM_002764:c.123-3304T>G INTRON1 Unknown significance rs781737393 This variant is a VUS because it does not have enough information. 1 1003 0.001 3 766 0.0039 0 524 0 2 764 0.0026 2 718 0.0028 8 3775 0.00211921 854399 chrX:106879245:G>A PRPS1 NM_002764:c.123-3280G>A INTRON1 Benign rs376913780 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 5 1003 0.005 0 766 0 0 524 0 0 764 0 0 718 0 5 3775 0.0013245 854400 chrX:106879267:C>T PRPS1 NM_002764:c.123-3258C>T INTRON1 Benign rs181723083 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 206 1003 0.2054 1 766 0.0013 7 524 0.0134 3 764 0.0039 6 718 0.0084 223 3775 0.0590728 854401 chrX:106879299:A>C PRPS1 NM_002764:c.123-3226A>C INTRON1 Benign rs777356985 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 22 1003 0.0219 1 766 0.0013 0 524 0 0 764 0 0 718 0 23 3775 0.00609272 854402 chrX:106879301:A>C PRPS1 NM_002764:c.123-3224A>C INTRON1 Unknown significance rs748942542 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 2 524 0.0038 0 764 0 0 718 0 2 3775 0.000529801 854403 chrX:106879304:A>C PRPS1 NM_002764:c.123-3221A>C INTRON1 Unknown significance rs201751847 This variant is a VUS because it does not have enough information. 854404 chrX:106879347:T>A PRPS1 NM_002764:c.123-3178T>A INTRON1 Unknown significance rs59904555 This variant is a VUS because it does not have enough information. 854405 chrX:106879361:T>C PRPS1 NM_002764:c.123-3164T>C INTRON1 Benign rs140723505 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 32 1003 0.0319 1 766 0.0013 0 524 0 0 764 0 0 718 0 33 3775 0.00874172 854406 chrX:106879361:T>G PRPS1 NM_002764:c.123-3164T>G INTRON1 Unknown significance This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 2 524 0.0038 0 764 0 0 718 0 2 3775 0.000529801 854407 chrX:106879376:G>A PRPS1 NM_002764:c.123-3149G>A INTRON1 Unknown significance rs772006987 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 1 764 0.0013 0 718 0 2 3775 0.000529801 854408 chrX:106879384:G>A PRPS1 NM_002764:c.123-3141G>A INTRON1 Benign rs113802590 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 22 766 0.0287 4 524 0.0076 1 764 0.0013 9 718 0.0125 36 3775 0.00953642 854409 chrX:106879384:G>T PRPS1 NM_002764:c.123-3141G>T INTRON1 Unknown significance rs113802590 This variant is a VUS because it does not have enough information. 854410 chrX:106879388:T>C PRPS1 NM_002764:c.123-3137T>C INTRON1 Unknown significance rs760450929 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 1 718 0.0014 2 3775 0.000529801 854411 chrX:106879402:G>T PRPS1 NM_002764:c.123-3123G>T INTRON1 Unknown significance rs763916436 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854412 chrX:106879439:G>A PRPS1 NM_002764:c.123-3086G>A INTRON1 Benign rs190639554 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 12 766 0.0157 0 524 0 0 764 0 0 718 0 12 3775 0.00317881 854413 chrX:106879474:C>T PRPS1 NM_002764:c.123-3051C>T INTRON1 Unknown significance rs763258140 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854414 chrX:106879509:C>T PRPS1 NM_002764:c.123-3016C>T INTRON1 Unknown significance rs182761573 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854415 chrX:106879546:C>T PRPS1 NM_002764:c.123-2979C>T INTRON1 Benign rs186485143 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 5 1003 0.005 0 766 0 0 524 0 0 764 0 0 718 0 5 3775 0.0013245 854416 chrX:106879551:T>C PRPS1 NM_002764:c.123-2974T>C INTRON1 Benign rs145869180 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 39 1003 0.0389 1 766 0.0013 2 524 0.0038 0 764 0 0 718 0 42 3775 0.0111258 854417 chrX:106879601:T>G PRPS1 NM_002764:c.123-2924T>G INTRON1 Benign rs5962869 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 231 1003 0.2303 1 766 0.0013 9 524 0.0172 3 764 0.0039 6 718 0.0084 250 3775 0.0662252 854418 chrX:106879634:G>A PRPS1 NM_002764:c.123-2891G>A INTRON1 Benign rs753253435 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 5 718 0.007 5 3775 0.0013245 854419 chrX:106879641:C>T PRPS1 NM_002764:c.123-2884C>T INTRON1 Unknown significance rs191417002 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854420 chrX:106879642:G>A PRPS1 NM_002764:c.123-2883G>A INTRON1 Benign rs141340480 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 40 764 0.0524 0 718 0 40 3775 0.010596 854421 chrX:106879649:C>G PRPS1 NM_002764:c.123-2876C>G INTRON1 Unknown significance rs749570109 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854422 chrX:106879663:A>T PRPS1 NM_002764:c.123-2862A>T INTRON1 Unknown significance rs756969417 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854423 chrX:106879744:T>- PRPS1 NM_002764:c.123-2781delT INTRON1 Unknown significance rs778474958 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 1 524 0.0019 1 764 0.0013 2 718 0.0028 5 3775 0.0013245 854424 chrX:106879797:T>C PRPS1 NM_002764:c.123-2728T>C INTRON1 Unknown significance rs769699724 This variant is a VUS because it does not have enough information. 854425 chrX:106879870:A>G PRPS1 NM_002764:c.123-2655A>G INTRON1 Unknown significance rs745436730 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854426 chrX:106879887:C>A PRPS1 NM_002764:c.123-2638C>A INTRON1 Unknown significance rs143310878 This variant is a VUS because it does not have enough information. 0 1003 0 3 766 0.0039 0 524 0 0 764 0 1 718 0.0014 4 3775 0.0010596 854427 chrX:106879955:G>T PRPS1 NM_002764:c.123-2570G>T INTRON1 Unknown significance rs183186635 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854428 chrX:106879968:A>G PRPS1 NM_002764:c.123-2557A>G INTRON1 Benign rs148324130 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 10 766 0.0131 1 524 0.0019 0 764 0 1 718 0.0014 12 3775 0.00317881 854429 chrX:106879984:G>C PRPS1 NM_002764:c.123-2541G>C INTRON1 Unknown significance rs774445249 This variant is a VUS because it does not have enough information. 854430 chrX:106880005:G>T PRPS1 NM_002764:c.123-2520G>T INTRON1 Unknown significance rs768420605 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854431 chrX:106880065:G>A PRPS1 NM_002764:c.123-2460G>A INTRON1 Unknown significance rs776491429 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854432 chrX:106880077:T>C PRPS1 NM_002764:c.123-2448T>C INTRON1 Unknown significance rs762042244 This variant is a VUS because it does not have enough information. 854433 chrX:106880090:G>T PRPS1 NM_002764:c.123-2435G>T INTRON1 Unknown significance rs187391300 This variant is a VUS because it does not have enough information. 2 1003 0.002 0 766 0 0 524 0 0 764 0 0 718 0 2 3775 0.000529801 854434 chrX:106880113:T>C PRPS1 NM_002764:c.123-2412T>C INTRON1 Unknown significance rs766729633 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 0 718 0 1 3775 0.000264901 854435 chrX:106880115:C>G PRPS1 NM_002764:c.123-2410C>G INTRON1 Unknown significance rs772072973 This variant is a VUS because it does not have enough information. 854436 chrX:106880151:T>C PRPS1 NM_002764:c.123-2374T>C INTRON1 Unknown significance rs774691877 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 1 524 0.0019 0 764 0 1 718 0.0014 3 3775 0.000794702 854437 chrX:106880155:A>C PRPS1 NM_002764:c.123-2370A>C INTRON1 Unknown significance rs370479557 This variant is a VUS because it does not have enough information. 854438 chrX:106880157:T>C PRPS1 NM_002764:c.123-2368T>C INTRON1 Unknown significance rs773309543 This variant is a VUS because it does not have enough information. 854439 chrX:106880182:A>G PRPS1 NM_002764:c.123-2343A>G INTRON1 Unknown significance rs192530289 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 1 764 0.0013 0 718 0 2 3775 0.000529801 854440 chrX:106880217:T>C PRPS1 NM_002764:c.123-2308T>C INTRON1 Unknown significance rs767699234 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854441 chrX:106880225:->TAT PRPS1 NM_002764:c.123-2300_123-2299insTAT INTRON1 Unknown significance rs753198935 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854442 chrX:106880262:A>G PRPS1 NM_002764:c.123-2263A>G INTRON1 Benign rs7886132 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 256 1003 0.2552 3 766 0.0039 60 524 0.1145 34 764 0.0445 39 718 0.0543 392 3775 0.103841 854443 chrX:106880304:TGT>- PRPS1 NM_002764:c.123-2221_123-2219delTGT INTRON1 Unknown significance rs757643117 This variant is a VUS because it does not have enough information. 854444 chrX:106880312:G>A PRPS1 NM_002764:c.123-2213G>A INTRON1 Benign rs150826893 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 5 1003 0.005 1 766 0.0013 43 524 0.0821 34 764 0.0445 39 718 0.0543 122 3775 0.0323179 854445 chrX:106880318:T>C PRPS1 NM_002764:c.123-2207T>C INTRON1 Unknown significance rs754332850 This variant is a VUS because it does not have enough information. 854446 chrX:106880334:T>A PRPS1 NM_002764:c.123-2191T>A INTRON1 Unknown significance rs568114648 This variant is a VUS because it does not have enough information. 854447 chrX:106880338:A>C PRPS1 NM_002764:c.123-2187A>C INTRON1 Unknown significance rs754256062 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854448 chrX:106880339:A>T PRPS1 NM_002764:c.123-2186A>T INTRON1 Unknown significance rs759996554 This variant is a VUS because it does not have enough information. 854449 chrX:106880355:C>T PRPS1 NM_002764:c.123-2170C>T INTRON1 Unknown significance rs757544212 This variant is a VUS because it does not have enough information. 3 1003 0.003 0 766 0 0 524 0 0 764 0 1 718 0.0014 4 3775 0.0010596 854450 chrX:106880394:T>A PRPS1 NM_002764:c.123-2131T>A INTRON1 Unknown significance rs183283933 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854451 chrX:106880415:C>T PRPS1 NM_002764:c.123-2110C>T INTRON1 Unknown significance rs187933931 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854452 chrX:106880420:A>G PRPS1 NM_002764:c.123-2105A>G INTRON1 Unknown significance rs370752684 This variant is a VUS because it does not have enough information. 854453 chrX:106880484:A>C PRPS1 NM_002764:c.123-2041A>C INTRON1 Unknown significance rs765588411 This variant is a VUS because it does not have enough information. 854454 chrX:106880507:G>A PRPS1 NM_002764:c.123-2018G>A INTRON1 Benign rs192462989 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 5 524 0.0095 0 764 0 0 718 0 5 3775 0.0013245 854455 chrX:106880649:A>G PRPS1 NM_002764:c.123-1876A>G INTRON1 Benign rs138261844 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 61 1003 0.0608 1 766 0.0013 2 524 0.0038 0 764 0 0 718 0 64 3775 0.0169536 854456 chrX:106880683:T>C PRPS1 NM_002764:c.123-1842T>C INTRON1 Unknown significance rs780618725 This variant is a VUS because it does not have enough information. 854457 chrX:106880685:A>G PRPS1 NM_002764:c.123-1840A>G INTRON1 Unknown significance rs746439481 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854458 chrX:106880751:A>G PRPS1 NM_002764:c.123-1774A>G INTRON1 Unknown significance rs749919993 This variant is a VUS because it does not have enough information. 854459 chrX:106880810:C>T PRPS1 NM_002764:c.123-1715C>T INTRON1 Unknown significance rs768671101 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854460 chrX:106880848:C>A PRPS1 NM_002764:c.123-1677C>A INTRON1 Unknown significance rs776383737 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854461 chrX:106880923:A>T PRPS1 NM_002764:c.123-1602A>T INTRON1 Unknown significance rs756110655 This variant is a VUS because it does not have enough information. 854462 chrX:106880943:G>A PRPS1 NM_002764:c.123-1582G>A INTRON1 Benign rs748024617 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 5 718 0.007 5 3775 0.0013245 854463 chrX:106881009:T>G PRPS1 NM_002764:c.123-1516T>G INTRON1 Benign rs16985261 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 228 1003 0.2273 1 766 0.0013 9 524 0.0172 3 764 0.0039 6 718 0.0084 247 3775 0.0654305 854464 chrX:106881081:T>C PRPS1 NM_002764:c.123-1444T>C INTRON1 Unknown significance rs774779711 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854465 chrX:106881160:->AT PRPS1 NM_002764:c.123-1365_123-1364insAT INTRON1 Unknown significance rs796383314 This variant is a VUS because it does not have enough information. 854466 chrX:106881176:A>T PRPS1 NM_002764:c.123-1349A>T INTRON1 Benign rs759817033 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 45 1003 0.0449 1 766 0.0013 0 524 0 0 764 0 0 718 0 46 3775 0.0121854 854467 chrX:106881178:A>- PRPS1 NM_002764:c.123-1347delA INTRON1 Unknown significance rs200547919 This variant is a VUS because it does not have enough information. 854468 chrX:106881178:A>T PRPS1 NM_002764:c.123-1347A>T INTRON1 Benign rs184457141 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 105 1003 0.1047 3 766 0.0039 9 524 0.0172 2 764 0.0026 9 718 0.0125 128 3775 0.0339073 854469 chrX:106881180:A>T PRPS1 NM_002764:c.123-1345A>T INTRON1 Benign rs7887547 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 663 1003 0.661 299 766 0.3903 177 524 0.3378 201 764 0.2631 215 718 0.2994 1555 3775 0.411921 854470 chrX:106881182:T>A PRPS1 NM_002764:c.123-1343T>A INTRON1 Benign rs60559960 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 215 1003 0.2144 6 766 0.0078 18 524 0.0344 0 764 0 6 718 0.0084 245 3775 0.0649007 854471 chrX:106881262:C>T PRPS1 NM_002764:c.123-1263C>T INTRON1 Unknown significance rs764715587 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854472 chrX:106881309:C>T PRPS1 NM_002764:c.123-1216C>T INTRON1 Benign rs147425497 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 18 1003 0.0179 0 766 0 5 524 0.0095 0 764 0 0 718 0 23 3775 0.00609272 854473 chrX:106881333:T>C PRPS1 NM_002764:c.123-1192T>C INTRON1 Unknown significance rs184335222 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854474 chrX:106881336:T>- PRPS1 NM_002764:c.123-1189delT INTRON1 Unknown significance rs57348912 This variant is a VUS because it does not have enough information. 854475 chrX:106881339:T>G PRPS1 NM_002764:c.123-1186T>G INTRON1 Unknown significance rs765575661 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854476 chrX:106881348:A>T PRPS1 NM_002764:c.123-1177A>T INTRON1 Unknown significance rs750730977 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 2 764 0.0026 1 718 0.0014 3 3775 0.000794702 854477 chrX:106881362:C>T PRPS1 NM_002764:c.123-1163C>T INTRON1 Unknown significance rs758052169 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854478 chrX:106881363:G>A PRPS1 NM_002764:c.123-1162G>A INTRON1 Unknown significance rs779642170 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854479 chrX:106881392:C>T PRPS1 NM_002764:c.123-1133C>T INTRON1 Benign rs112965644 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 29 1003 0.0289 0 766 0 1 524 0.0019 0 764 0 0 718 0 30 3775 0.00794702 854480 chrX:106881584:C>T PRPS1 NM_002764:c.123-941C>T INTRON1 Unknown significance rs181913459 This variant is a VUS because it does not have enough information. 854481 chrX:106881619:G>A PRPS1 NM_002764:c.123-906G>A INTRON1 Unknown significance rs779971354 This variant is a VUS because it does not have enough information. 854482 chrX:106881753:C>G PRPS1 NM_002764:c.123-772C>G INTRON1 Unknown significance rs754423996 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854483 chrX:106881765:C>T PRPS1 NM_002764:c.123-760C>T INTRON1 Unknown significance rs781229093 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 0 718 0 1 3775 0.000264901 854484 chrX:106881805:T>A PRPS1 NM_002764:c.123-720T>A INTRON1 Unknown significance rs12854967 This variant is a VUS because it does not have enough information. 854485 chrX:106881815:T>G PRPS1 NM_002764:c.123-710T>G INTRON1 Unknown significance rs12854983 This variant is a VUS because it does not have enough information. 854486 chrX:106881867:T>- PRPS1 NM_002764:c.123-658delT INTRON1 Unknown significance rs750708928 This variant is a VUS because it does not have enough information. 854487 chrX:106881895:C>T PRPS1 NM_002764:c.123-630C>T INTRON1 Unknown significance rs186400784 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854488 chrX:106881899:C>G PRPS1 NM_002764:c.123-626C>G INTRON1 Unknown significance rs769767405 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854489 chrX:106881907:C>T PRPS1 NM_002764:c.123-618C>T INTRON1 Unknown significance rs749166704 This variant is a VUS because it does not have enough information. 854490 chrX:106881939:C>G PRPS1 NM_002764:c.123-586C>G INTRON1 Unknown significance rs777721203 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854491 chrX:106881954:->TATTT PRPS1 NM_002764:c.123-571_123-570insTATTT INTRON1 Benign rs749021712 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 18 1003 0.0179 0 766 0 1 524 0.0019 0 764 0 0 718 0 19 3775 0.00503311 854492 chrX:106881954:->TATTTTATTT PRPS1 NM_002764:c.123-571_123-570insTATTTTATTT INTRON1 Benign rs749021712 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 6 1003 0.006 0 766 0 0 524 0 0 764 0 0 718 0 6 3775 0.0015894 854493 chrX:106881954:TATTT>- PRPS1 NM_002764:c.123-571_123-567delTATTT INTRON1 Unknown significance rs758517960 This variant is a VUS because it does not have enough information. 854494 chrX:106881968:T>C PRPS1 NM_002764:c.123-557T>C INTRON1 Unknown significance rs768354851 This variant is a VUS because it does not have enough information. 854495 chrX:106882046:T>C PRPS1 NM_002764:c.123-479T>C INTRON1 Unknown significance rs778725410 This variant is a VUS because it does not have enough information. 854496 chrX:106882048:C>T PRPS1 NM_002764:c.123-477C>T INTRON1 Benign rs775521805 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 4 718 0.0056 4 3775 0.0010596 854497 chrX:106882077:C>T PRPS1 NM_002764:c.123-448C>T INTRON1 Unknown significance rs748356756 This variant is a VUS because it does not have enough information. 854498 chrX:106882108:G>A PRPS1 NM_002764:c.123-417G>A INTRON1 Benign rs760853439 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 4 718 0.0056 4 3775 0.0010596 854499 chrX:106882182:C>T PRPS1 NM_002764:c.123-343C>T INTRON1 Unknown significance rs768618401 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854500 chrX:106882184:C>T PRPS1 NM_002764:c.123-341C>T INTRON1 Benign rs777255715 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 5 1003 0.005 0 766 0 0 524 0 0 764 0 0 718 0 5 3775 0.0013245 854501 chrX:106882185:G>T PRPS1 NM_002764:c.123-340G>T INTRON1 Unknown significance rs190557438 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854502 chrX:106882259:C>T PRPS1 NM_002764:c.123-266C>T INTRON1 Benign rs181077764 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 10 764 0.0131 0 718 0 10 3775 0.00264901 854503 chrX:106882275:C>T PRPS1 NM_002764:c.123-250C>T INTRON1 Benign rs750818907 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 6 1003 0.006 0 766 0 0 524 0 0 764 0 0 718 0 6 3775 0.0015894 854504 chrX:106882296:C>T PRPS1 NM_002764:c.123-229C>T INTRON1 Unknown significance rs763255133 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 2 764 0.0026 0 718 0 2 3775 0.000529801 854505 chrX:106882326:C>T PRPS1 NM_002764:c.123-199C>T INTRON1 Benign rs368386568 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 1 1003 0.001 0 766 0 1 524 0.0019 4 764 0.0052 1 718 0.0014 7 3775 0.0018543 854506 chrX:106882327:G>A PRPS1 NM_002764:c.123-198G>A INTRON1 Unknown significance rs773495942 This variant is a VUS because it does not have enough information. 854507 chrX:106882344:T>A PRPS1 NM_002764:c.123-181T>A INTRON1 Unknown significance rs760844833 This variant is a VUS because it does not have enough information. 854508 chrX:106882373:A>C PRPS1 NM_002764:c.123-152A>C INTRON1 Benign rs751139553 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 4 718 0.0056 4 3775 0.0010596 854509 chrX:106882478:T>C PRPS1 NM_002764:c.123-47T>C INTRON1 Unknown significance rs370316413 This variant is a VUS because it does not have enough information. 1 6728 0.000148633 0 3835 0 1 10563 0.0000946701 0 8496 0 0 9319 0 0 6637 0 0 4530 0 1 47972 0.0000208455 0 633 0 0 10120 0 1 87707 0.0000114016 854510 chrX:106882478:T>G PRPS1 NM_002764:c.123-47T>G INTRON1 Unknown significance rs370316413 This variant is a VUS because it does not have enough information. 0 8496 0 0 9319 0 0 6637 0 0 4530 0 5 47972 0.000104227 0 633 0 0 10120 0 5 87707 0.000057008 854511 chrX:106882489:A>G PRPS1 NM_002764:c.123-36A>G INTRON1 Benign rs373779872 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 8 6728 0.00118906 1 3835 0.000260756 9 10563 0.000852031 0 1003 0 0 766 0 3 524 0.0057 0 764 0 0 718 0 3 3775 0.000794702 1 8498 0.000117675 6 9321 0.000643708 0 6638 0 0 4530 0 50 47982 0.00104206 0 633 0 1 10122 0.0000987947 58 87724 0.000661165 854512 chrX:106882495:T>G PRPS1 NM_002764:c.123-30T>G INTRON1 Unknown significance rs367746767 This variant is a VUS because it does not have enough information. 2 6728 0.000297265 0 3835 0 2 10563 0.00018934 0 8504 0 0 9321 0 0 6638 0 0 4530 0 2 47990 0.0000416753 0 633 0 0 10123 0 2 87739 0.0000227949 854513 chrX:106882500:C>T PRPS1 NM_002764:c.123-25C>T INTRON1 Unknown significance rs201020362 This variant is a VUS because it does not have enough information. 854514 chrX:106882507:->T PRPS1 NM_002764:c.123-18_123-17insT INTRON1 Unknown significance rs750392051 This variant is a VUS because it does not have enough information. 854515 chrX:106882525:T>C PRPS1 NM_002764:p.Ser41Ser NM_002764:c.123T>C EXON2 Unknown significance rs777304127 This variant is a VUS because it does not have enough information. 854516 chrX:106882531:A>C PRPS1 NM_002764:p.Glu43Asp NM_002764:c.129A>C EXON2 Pathogenic Rosenberg-Chutorian syndrome 20301731,20301532,17701900 rs80338731 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 0.23 N 0.091;0.166 T 0.002 B 0 D 0.999544 A;A 2.24 C 854517 chrX:106882556:G>C PRPS1 NM_002764:p.Asp52His NM_002764:c.154G>C EXON2 Pathogenic Phosphoribosylpyrophosphate synthetase superactivity 171280,7593598,20301734,23509005 rs137852542 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 1.048 C 0.0;0.01 D 1.0 D 0 D 1 A;A 4.7 C 854518 chrX:106882579:T>A PRPS1 NM_002764:p.Gly59Gly NM_002764:c.177T>A EXON2 Unknown significance rs147896410 This variant is a VUS because it does not have enough information. 1 6728 0.000148633 0 3835 0 1 10563 0.0000946701 0 8516 0 0 9324 0 0 6638 0 0 4530 0 1 47999 0.0000208338 0 633 0 0 10124 0 1 87764 0.0000113942 854520 chrX:106882585:C>A PRPS1 NM_002764:p.Gly61Gly NM_002764:c.183C>A EXON2 Unknown significance rs371538576 This variant is a VUS because it does not have enough information. 0 8516 0 0 9324 0 1 6638 0.000150648 0 4530 0 0 47999 0 0 633 0 0 10124 0 1 87764 0.0000113942 854519 chrX:106882585:C>T PRPS1 NM_002764:p.Gly61Gly NM_002764:c.183C>T EXON2 Unknown significance rs371538576 This variant is a VUS because it does not have enough information. 1 6728 0.000148633 1 3835 0.000260756 2 10563 0.00018934 1 8516 0.000117426 0 9324 0 0 6638 0 0 4530 0 1 47999 0.0000208338 0 633 0 0 10124 0 2 87764 0.0000227884 854521 chrX:106882586:G>A PRPS1 NM_002764:p.Glu62Lys NM_002764:c.184G>A EXON2 Unknown significance rs773719662 This variant is a VUS because it does not have enough information. 1.048 C 0.195;0.165 T 0.792 P 0.00001 D 0.999999 D;D 4.5 C 0 8516 0 0 9324 0 0 6638 0 0 4530 0 1 47999 0.0000208338 0 633 0 0 10124 0 1 87764 0.0000113942 854522 chrX:106882595:G>A PRPS1 NM_002764:p.Asp65Asn NM_002764:c.193G>A EXON2 Pathogenic Sensorineural deafness, nonsyndromic 20021999,20301607,21834172 rs180177151 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 1.048 C 0.119;0.057 T 0.181 B 0 D 1 A;A;A 4.5 C 854523 chrX:106882645:A>G PRPS1 NM_002764:p.Ser81Ser NM_002764:c.243A>G EXON2 Unknown significance rs780551723 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 0 8507 0 0 9324 0 0 6638 0 0 4530 0 1 47994 0.0000208359 0 633 0 0 10123 0 1 87749 0.0000113961 854524 chrX:106882650:G>T PRPS1 NM_002764:p.Ser83Ile NM_002764:c.248G>T EXON2 Unknown significance rs767243595 This variant is a VUS because it does not have enough information. 1.048 C 0.026;0.077;0.011 D;T;D 0.688 P 0.000001 D 0.99965 D;D;D;D 4.5 C 854525 chrX:106882651:C>T PRPS1 NM_002764:p.Ser83Ser NM_002764:c.249C>T EXON2 Unknown significance rs750054054 This variant is a VUS because it does not have enough information. 1 8498 0.000117675 0 9324 0 0 6638 0 0 4530 0 0 47994 0 0 633 0 0 10120 0 1 87737 0.0000113977 854526 chrX:106882661:G>A PRPS1 NM_002764:p.Ala87Thr NM_002764:c.259G>A EXON2 Pathogenic Sensorineural deafness, nonsyndromic 20021999,20301607,8968763,21834172 rs180177152 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 1.048 C 0.017;0.016;0.021 D 0.987 D 0 D 1 A;A;A;A;A 4.5 C 854527 chrX:106882663:A>C PRPS1 NM_002764:p.Ala87Ala NM_002764:c.261A>C EXON2 Unknown significance rs755850703 This variant is a VUS because it does not have enough information. 0 8489 0 1 9323 0.000107262 0 6638 0 0 4530 0 0 47992 0 0 633 0 0 10120 0 1 87725 0.0000113993 854528 chrX:106882672:A>C PRPS1 NM_002764:p.Pro90Pro NM_002764:c.270A>C EXON2 Unknown significance rs766786656 This variant is a VUS because it does not have enough information. 1 8478 0.000117952 0 9323 0 0 6638 0 0 4530 0 0 47974 0 0 633 0 0 10120 0 1 87696 0.000011403 854529 chrX:106882672:A>T PRPS1 NM_002764:p.Pro90Pro NM_002764:c.270A>T EXON2 Unknown significance rs766786656 This variant is a VUS because it does not have enough information. 0 8478 0 0 9323 0 0 6638 0 0 4530 0 1 47974 0.0000208446 0 633 0 0 10120 0 1 87696 0.000011403 854530 chrX:106882690:G>A PRPS1 NM_002764:p.Arg96Arg NM_002764:c.288G>A EXON2 Unknown significance rs752194539 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 2 764 0.0026 0 718 0 2 3775 0.000529801 0 8375 0 0 9317 0 25 6633 0.00376903 0 4529 0 0 47919 0 0 630 0 0 10114 0 25 87517 0.000285659 854531 chrX:106882709:->A PRPS1 NM_002764:c.306+1_306+2insA INTRON2 Unknown significance rs755093762 This variant is a VUS because it does not have enough information. 854532 chrX:106882709:->AGCCGGGCGCCAATCTCAGCCAAGCTT PRPS1 NM_002764:c.306+1_306+2insAGCCGGGCGCCAATCTCAGCCAAGCTT INTRON2 Unknown significance rs755093762 This variant is a VUS because it does not have enough information. 854533 chrX:106882709:->AGCCGGGCGCCAATCTCAGCCAAGCTTGTTGCAAATATGCTATCT PRPS1 NM_002764:c.306+1_306+2insAGCCGGGCGCCAATCTCAGCCAAGCTTGTTGCAAATATGCTATCT INTRON2 Unknown significance rs755093762 This variant is a VUS because it does not have enough information. 854534 chrX:106882710:->CCGGGCGCCAATCTCAGCCAAGCTTGTTGCAAATATGC PRPS1 NM_002764:c.306+2_306+3insCCGGGCGCCAATCTCAGCCAAGCTTGTTGCAAATATGC INTRON2 Unknown significance rs758657216 This variant is a VUS because it does not have enough information. 854535 chrX:106882726:->T PRPS1 NM_002764:c.306+18_306+19insT INTRON2 Unknown significance rs777885394 This variant is a VUS because it does not have enough information. 0 8109 0 0 9265 0 0 6557 0 0 4520 0 1 47536 0.0000210367 0 629 0 0 10083 0 1 86699 0.0000115342 854536 chrX:106882803:G>T PRPS1 NM_002764:c.306+95G>T INTRON2 Unknown significance rs11797233 This variant is a VUS because it does not have enough information. 854537 chrX:106882884:C>T PRPS1 NM_002764:c.306+176C>T INTRON2 Unknown significance rs760049067 This variant is a VUS because it does not have enough information. 854538 chrX:106882909:G>A PRPS1 NM_002764:c.306+201G>A INTRON2 Unknown significance rs372166721 This variant is a VUS because it does not have enough information. 854539 chrX:106882909:G>C PRPS1 NM_002764:c.306+201G>C INTRON2 Unknown significance rs372166721 This variant is a VUS because it does not have enough information. 854540 chrX:106882979:C>T PRPS1 NM_002764:c.306+271C>T INTRON2 Unknown significance rs567661963 This variant is a VUS because it does not have enough information. 2 1003 0.002 0 766 0 0 524 0 0 764 0 0 718 0 2 3775 0.000529801 854541 chrX:106883012:C>T PRPS1 NM_002764:c.306+304C>T INTRON2 Unknown significance rs761433252 This variant is a VUS because it does not have enough information. 854542 chrX:106883107:->ATAG PRPS1 NM_002764:c.306+399_306+400insATAG INTRON2 Benign rs777809064 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 30 1003 0.0299 0 766 0 3 524 0.0057 0 764 0 1 718 0.0014 34 3775 0.00900662 854543 chrX:106883107:ATAG>- PRPS1 NM_002764:c.306+399_306+402delATAG INTRON2 Unknown significance rs749112922 This variant is a VUS because it does not have enough information. 2 1003 0.002 0 766 0 0 524 0 2 764 0.0026 0 718 0 4 3775 0.0010596 854544 chrX:106883127:A>G PRPS1 NM_002764:c.306+419A>G INTRON2 Unknown significance rs112061305 This variant is a VUS because it does not have enough information. 854545 chrX:106883183:A>G PRPS1 NM_002764:c.306+475A>G INTRON2 Benign rs113432416 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 29 1003 0.0289 0 766 0 2 524 0.0038 0 764 0 0 718 0 31 3775 0.00821192 854546 chrX:106883216:C>A PRPS1 NM_002764:c.306+508C>A INTRON2 Unknown significance rs780394440 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854547 chrX:106883236:C>T PRPS1 NM_002764:c.306+528C>T INTRON2 Benign rs143984346 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 1 766 0.0013 0 524 0 17 764 0.0223 0 718 0 18 3775 0.00476821 854548 chrX:106883237:G>A PRPS1 NM_002764:c.306+529G>A INTRON2 Benign rs148639312 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 50 1003 0.0499 0 766 0 3 524 0.0057 0 764 0 0 718 0 53 3775 0.0140397 854549 chrX:106883252:T>G PRPS1 NM_002764:c.306+544T>G INTRON2 Unknown significance rs765822776 This variant is a VUS because it does not have enough information. 854550 chrX:106883291:G>A PRPS1 NM_002764:c.306+583G>A INTRON2 Benign rs142094002 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 19 1003 0.0189 0 766 0 0 524 0 0 764 0 0 718 0 19 3775 0.00503311 854551 chrX:106883306:C>T PRPS1 NM_002764:c.306+598C>T INTRON2 Benign rs186057710 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 27 1003 0.0269 1 766 0.0013 0 524 0 0 764 0 0 718 0 28 3775 0.00741722 854552 chrX:106883339:C>T PRPS1 NM_002764:c.306+631C>T INTRON2 Unknown significance rs770308633 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854553 chrX:106883386:G>A PRPS1 NM_002764:c.306+678G>A INTRON2 Unknown significance rs773687656 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854554 chrX:106883389:G>A PRPS1 NM_002764:c.306+681G>A INTRON2 Unknown significance rs763348546 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854555 chrX:106883404:T>G PRPS1 NM_002764:c.306+696T>G INTRON2 Unknown significance rs766648581 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854556 chrX:106883432:C>T PRPS1 NM_002764:c.307-700C>T INTRON2 Unknown significance rs191234504 This variant is a VUS because it does not have enough information. 0 1003 0 3 766 0.0039 0 524 0 0 764 0 0 718 0 3 3775 0.000794702 854557 chrX:106883433:G>A PRPS1 NM_002764:c.307-699G>A INTRON2 Unknown significance rs376728633 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854558 chrX:106883433:G>C PRPS1 NM_002764:c.307-699G>C INTRON2 Unknown significance rs376728633 This variant is a VUS because it does not have enough information. 854559 chrX:106883438:G>A PRPS1 NM_002764:c.307-694G>A INTRON2 Unknown significance rs182507328 This variant is a VUS because it does not have enough information. 0 1003 0 2 766 0.0026 0 524 0 0 764 0 0 718 0 2 3775 0.000529801 854560 chrX:106883442:C>T PRPS1 NM_002764:c.307-690C>T INTRON2 Unknown significance rs752284346 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 0 718 0 1 3775 0.000264901 854561 chrX:106883454:C>A PRPS1 NM_002764:c.307-678C>A INTRON2 Unknown significance rs367607000 This variant is a VUS because it does not have enough information. 854562 chrX:106883457:A>G PRPS1 NM_002764:c.307-675A>G INTRON2 Unknown significance rs113057540 This variant is a VUS because it does not have enough information. 854563 chrX:106883487:G>A PRPS1 NM_002764:c.307-645G>A INTRON2 Unknown significance rs778618665 This variant is a VUS because it does not have enough information. 854564 chrX:106883504:A>G PRPS1 NM_002764:c.307-628A>G INTRON2 Unknown significance rs112257441 This variant is a VUS because it does not have enough information. 854565 chrX:106883507:G>A PRPS1 NM_002764:c.307-625G>A INTRON2 Unknown significance rs755633573 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854566 chrX:106883575:->A PRPS1 NM_002764:c.307-557_307-556insA INTRON2 Unknown significance rs759522021 This variant is a VUS because it does not have enough information. 854567 chrX:106883688:G>A PRPS1 NM_002764:c.307-444G>A INTRON2 Unknown significance rs747973583 This variant is a VUS because it does not have enough information. 854568 chrX:106883713:C>G PRPS1 NM_002764:c.307-419C>G INTRON2 Unknown significance rs758065373 This variant is a VUS because it does not have enough information. 854569 chrX:106883738:C>G PRPS1 NM_002764:c.307-394C>G INTRON2 Unknown significance rs764172370 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 3 718 0.0042 3 3775 0.000794702 854570 chrX:106883782:G>A PRPS1 NM_002764:c.307-350G>A INTRON2 Unknown significance rs778157677 This variant is a VUS because it does not have enough information. 854571 chrX:106883802:A>G PRPS1 NM_002764:c.307-330A>G INTRON2 Unknown significance rs186181815 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 1 524 0.0019 0 764 0 0 718 0 1 3775 0.000264901 854572 chrX:106883803:A>C PRPS1 NM_002764:c.307-329A>C INTRON2 Unknown significance rs757137560 This variant is a VUS because it does not have enough information. 0 1003 0 2 766 0.0026 0 524 0 0 764 0 0 718 0 2 3775 0.000529801 854573 chrX:106883860:A>G PRPS1 NM_002764:c.307-272A>G INTRON2 Unknown significance rs778589733 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854574 chrX:106883962:G>T PRPS1 NM_002764:c.307-170G>T INTRON2 Benign rs17847389 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 5 1003 0.005 1 766 0.0013 44 524 0.084 34 764 0.0445 39 718 0.0543 123 3775 0.0325828 854575 chrX:106883998:G>- PRPS1 NM_002764:c.307-134delG INTRON2 Unknown significance rs60316832 This variant is a VUS because it does not have enough information. 854576 chrX:106884025:A>G PRPS1 NM_002764:c.307-107A>G INTRON2 Unknown significance rs190505754 This variant is a VUS because it does not have enough information. 0 1003 0 2 766 0.0026 0 524 0 0 764 0 0 718 0 2 3775 0.000529801 854577 chrX:106884026:T>C PRPS1 NM_002764:c.307-106T>C INTRON2 Unknown significance rs41300247 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854578 chrX:106884046:G>A PRPS1 NM_002764:c.307-86G>A INTRON2 Unknown significance rs748276680 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854579 chrX:106884057:A>G PRPS1 NM_002764:c.307-75A>G INTRON2 Benign rs769832506 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 5 1003 0.005 0 766 0 0 524 0 0 764 0 0 718 0 5 3775 0.0013245 854580 chrX:106884081:T>A PRPS1 NM_002764:c.307-51T>A INTRON2 Unknown significance rs374952552 This variant is a VUS because it does not have enough information. 0 6726 0 1 3835 0.000260756 1 10561 0.000094688 854581 chrX:106884095:T>- PRPS1 NM_002764:c.307-37delT INTRON2 Unknown significance rs747340670 This variant is a VUS because it does not have enough information. 0 8288 0 0 9315 0 0 6629 0 0 4523 0 1 47861 0.0000208938 0 631 0 0 10120 0 1 87367 0.000011446 854582 chrX:106884095:T>C PRPS1 NM_002764:c.307-37T>C INTRON2 Unknown significance rs779526573 This variant is a VUS because it does not have enough information. 854583 chrX:106884101:G>C PRPS1 NM_002764:c.307-31G>C INTRON2 Unknown significance rs182983731 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 0 8318 0 0 9317 0 18 6631 0.00271452 0 4526 0 0 47866 0 0 632 0 0 10119 0 18 87409 0.000205928 854584 chrX:106884103:T>C PRPS1 NM_002764:c.307-29T>C INTRON2 Unknown significance rs758465030 This variant is a VUS because it does not have enough information. 0 8336 0 1 9317 0.000107331 0 6631 0 0 4526 0 0 47872 0 0 632 0 0 10120 0 1 87434 0.0000114372 854585 chrX:106884105:T>C PRPS1 NM_002764:c.307-27T>C INTRON2 Unknown significance rs368218592 This variant is a VUS because it does not have enough information. 1 6728 0.000148633 0 3835 0 1 10563 0.0000946701 0 8340 0 0 9318 0 0 6633 0 0 4527 0 2 47880 0.0000417711 0 632 0 0 10120 0 2 87450 0.0000228702 854586 chrX:106884106:T>G PRPS1 NM_002764:c.307-26T>G INTRON2 Unknown significance rs747178513 This variant is a VUS because it does not have enough information. 854587 chrX:106884107:C>T PRPS1 NM_002764:c.307-25C>T INTRON2 Unknown significance rs771144683 This variant is a VUS because it does not have enough information. 854588 chrX:106884112:C>T PRPS1 NM_002764:c.307-20C>T INTRON2 Unknown significance rs775258743 This variant is a VUS because it does not have enough information. 854589 chrX:106884124:C>T PRPS1 NM_002764:c.307-8C>T INTRON2 Unknown significance rs749164598 This variant is a VUS because it does not have enough information. 0 8445 0 0 9323 0 1 6638 0.000150648 0 4530 0 0 47938 0 0 632 0 0 10125 0 1 87631 0.0000114115 854590 chrX:106884127:T>- PRPS1 NM_002764:c.307-5delT INTRON2 Unknown significance rs771206190 This variant is a VUS because it does not have enough information. 0 8458 0 0 9323 0 0 6638 0 0 4530 0 1 47943 0.0000208581 0 632 0 0 10125 0 1 87649 0.0000114091 854591 chrX:106884140:G>A PRPS1 NM_002764:p.Ala105Ala NM_002764:c.315G>A EXON3 Unknown significance rs768455048 This variant is a VUS because it does not have enough information. 0 8508 0 0 9324 0 0 6638 0 0 4530 0 1 47978 0.0000208429 0 633 0 0 10125 0 1 87736 0.0000113978 854592 chrX:106884160:T>C PRPS1 NM_002764:p.Val112Ala NM_002764:c.335T>C EXON3 Unknown significance rs11541075 This variant is a VUS because it does not have enough information. 1.061 C 0.0 D 0.988 D 0 D 0.999999 D;D;D 4.75 C 854593 chrX:106884161:T>C PRPS1 NM_002764:p.Val112Val NM_002764:c.336T>C EXON3 Benign Arts syndrome; Arts Syndrome 20301738 rs80338674 Pathogenicity is based on ClinVar submissions. All submitters agree with this pathogenicity. 854594 chrX:106884162:G>T PRPS1 NM_002764:p.Ala113Ser NM_002764:c.337G>T EXON3 Pathogenic Hearing loss, non-syndromic 20301607,25182139,21834172 rs587781261 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 1.048 C 0.0 D 1.0 D 0 D 1 D;D;D 4.75 C 854595 chrX:106884166:A>G PRPS1 NM_002764:p.Asn114Ser NM_002764:c.341A>G EXON3 Pathogenic Phosphoribosylpyrophosphate synthetase superactivity 8253776,7593598,20301734,2423135,1664177 rs137852540 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 1.199 C 0.002;0.001 D 0.68 P 0 D 0.999976 A;A;A;A;A 4.75 C 854596 chrX:106884168:A>G PRPS1 NM_002764:p.Met115Val NM_002764:c.343A>G EXON3 Pathogenic 20301607,25182139,20301532,20301731,21834172 rs587781262 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 1.199 C 0.001;0.002 D 0.497 P 0 D 0.99998 D;D;D 4.75 C 854597 chrX:106884169:T>C PRPS1 NM_002764:p.Met115Thr NM_002764:c.344T>C EXON3 Pathogenic Charcot-Marie-Tooth disease 5 20301731,20301532,17701900 rs80338732 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 1.061 C 0.0 D 0.972 D 0 D 0.999992 A;A;A;A 3.58 C 854598 chrX:106884173:A>G PRPS1 NM_002764:p.Leu116Leu NM_002764:c.348A>G EXON3 Unknown significance rs774382720 This variant is a VUS because it does not have enough information. 0 8516 0 3 9324 0.00032175 0 6638 0 0 4530 0 0 47996 0 0 633 0 0 10125 0 3 87762 0.0000341834 854599 chrX:106884187:C>G PRPS1 NM_002764:p.Ala121Gly NM_002764:c.362C>G EXON3 Pathogenic Charcot-Marie-Tooth disease 5 24285972,20301731,20301532 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 0.935 N 0.0 D 0.875 P 0 D 0.999861 D;D;D 3.88 C 854600 chrX:106884210:C>A PRPS1 NM_002764:p.Leu129Ile NM_002764:c.385C>A EXON3 Pathogenic Phosphoribosylpyrophosphate synthetase superactivity 7593598,20301734 rs137852543 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 0.935 N 0.001;0.0 D 0.982 D 0.000001 D 0.997099 A;A;A;A;A 3.05 C 854601 chrX:106884223:A>C PRPS1 NM_002764:p.Gln133Pro NM_002764:c.398A>C EXON3 Pathogenic Phosphoribosylpyrophosphate synthetase deficiency 20301738,17701896 rs80338675 Pathogenicity is based on ClinVar submissions and the literature provided in PubMed. 1.199 C 0.0 D 0.997 D 0 D 1 A;A;A;A 4.84 C 854602 chrX:106884238:T>A PRPS1 NM_002764:c.405+8T>A INTRON3 Unknown significance rs761682942 This variant is a VUS because it does not have enough information. 0.144 N 0.002 D 1 D;N;N 3.91 C 0 8509 0 0 9312 0 0 6629 0 0 4528 0 0 47913 0 0 632 0 1 10091 0.0000990982 1 87614 0.0000114137 854603 chrX:106884253:G>T PRPS1 NM_002764:c.405+23G>T INTRON3 Unknown significance rs767084172 This variant is a VUS because it does not have enough information. -0.248 N 0.214 T 1 N;N;N;N;N 0.844 C 0 8477 0 0 9247 0 0 6558 0 0 4515 0 1 47464 0.0000210686 0 628 0 0 9975 0 1 86864 0.0000115122 854604 chrX:106884285:A>G PRPS1 NM_002764:c.405+55A>G INTRON3 Unknown significance rs772859341 This variant is a VUS because it does not have enough information. 0.237 N 0.0 D 1 N;N;N;N;N -1.24 N 0 8222 0 1 8523 0.00011733 0 6094 0 0 4282 0 0 43653 0 0 588 0 0 9371 0 1 80733 0.0000123865 854605 chrX:106884319:C>T PRPS1 NM_002764:c.405+89C>T INTRON3 Unknown significance rs760403126 This variant is a VUS because it does not have enough information. 0.789 N 0.0 D 1 N;N;N;N;N 2.5 C 0 6960 0 0 5659 0 0 4605 0 0 3584 0 1 32498 0.0000307711 0 474 0 0 7938 0 1 61718 0.0000162027 854606 chrX:106884332:A>T PRPS1 NM_002764:c.405+102A>T INTRON3 Unknown significance rs766195011 This variant is a VUS because it does not have enough information. 1.006 C 1 N;N;N;N;N -9.75 N 0 6129 0 0 4395 0 0 3732 0 0 3134 0 1 26601 0.0000375926 0 421 0 0 7172 0 1 51584 0.0000193859 854607 chrX:106884334:A>G PRPS1 NM_002764:c.405+104A>G INTRON3 Unknown significance rs749779821 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 0 764 0 1 718 0.0014 1 3775 0.000264901 854608 chrX:106884342:G>T PRPS1 NM_002764:c.405+112G>T INTRON3 Unknown significance rs755413640 This variant is a VUS because it does not have enough information. 0 5429 0 0 3212 0 3 2993 0.00100234 0 2727 0 0 21922 0 0 359 0 0 6551 0 3 43193 0.0000694557 854609 chrX:106884346:T>C PRPS1 NM_002764:c.405+116T>C INTRON3 Unknown significance rs765552257 This variant is a VUS because it does not have enough information. 0 5077 0 0 2715 0 1 2741 0.00036483 0 2590 0 0 20211 0 0 346 0 0 6300 0 1 39980 0.0000250125 854610 chrX:106884347:C>T PRPS1 NM_002764:c.405+117C>T INTRON3 Unknown significance rs753199324 This variant is a VUS because it does not have enough information. 1 5075 0.000197044 0 2673 0 0 2724 0 0 2577 0 0 20062 0 0 345 0 0 6272 0 1 39728 0.0000251712 854611 chrX:106884353:->CATT PRPS1 NM_002764:c.405+123_405+124insCATT INTRON3 Unknown significance rs747112610 This variant is a VUS because it does not have enough information. 854613 chrX:106884381:C>A PRPS1 NM_002764:c.405+151C>A INTRON3 Unknown significance rs771409227 This variant is a VUS because it does not have enough information. 0 2715 0 0 673 0 0 1052 0 0 1755 0 0 10811 0 0 245 0 2 5036 0.000397141 2 22287 0.0000897384 854612 chrX:106884381:C>T PRPS1 NM_002764:c.405+151C>T INTRON3 Unknown significance rs771409227 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 0 2715 0 0 673 0 0 1052 0 0 1755 0 1 10811 0.0000924984 0 245 0 0 5036 0 1 22287 0.0000448692 854614 chrX:106884382:T>G PRPS1 NM_002764:c.405+152T>G INTRON3 Unknown significance rs747156350 This variant is a VUS because it does not have enough information. 0 2731 0 0 681 0 0 1059 0 0 1756 0 1 10830 0.0000923361 0 241 0 0 5052 0 1 22350 0.0000447427 854615 chrX:106884461:C>A PRPS1 NM_002764:c.405+231C>A INTRON3 Unknown significance rs775783311 This variant is a VUS because it does not have enough information. 854616 chrX:106884521:T>- PRPS1 NM_002764:c.405+291delT INTRON3 Benign rs774581026 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 4 718 0.0056 4 3775 0.0010596 854618 chrX:106884526:C>G PRPS1 NM_002764:c.405+296C>G INTRON3 Benign This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 0 766 0 0 524 0 0 764 0 4 718 0.0056 4 3775 0.0010596 854617 chrX:106884526:C>T PRPS1 NM_002764:c.405+296C>T INTRON3 Unknown significance This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854619 chrX:106884535:G>A PRPS1 NM_002764:c.405+305G>A INTRON3 Benign rs59783882 This variant contains a MAF in at least one population that meets or exceeds our maximum cutoff of 0.005. 0 1003 0 1 766 0.0013 1 524 0.0019 85 764 0.1113 36 718 0.0501 123 3775 0.0325828 854620 chrX:106884540:T>C PRPS1 NM_002764:c.405+310T>C INTRON3 Unknown significance rs763687524 This variant is a VUS because it does not have enough information. 0 1003 0 0 766 0 0 524 0 1 764 0.0013 0 718 0 1 3775 0.000264901 854621 chrX:106884542:A>C PRPS1 NM_002764:c.405+312A>C INTRON3 Unknown significance rs764384343 This variant is a VUS because it does not have enough information. 854622 chrX:106884561:T>C PRPS1 NM_002764:c.405+331T>C INTRON3 Unknown significance rs753343045 This variant is a VUS because it does not have enough information. 1 1003 0.001 0 766 0 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854623 chrX:106884618:C>G PRPS1 NM_002764:c.405+388C>G INTRON3 Unknown significance rs188957036 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854624 chrX:106884649:G>A PRPS1 NM_002764:c.405+419G>A INTRON3 Unknown significance rs765183525 This variant is a VUS because it does not have enough information. 0 1003 0 1 766 0.0013 0 524 0 0 764 0 0 718 0 1 3775 0.000264901 854625 chrX:106884676:C>T PRPS1 NM_002764:c.405+446C>T INTRON3 Unknown significance rs369157421 This variant is a VUS because it does not have enough information. 854626 chrX:106884740:C>A PRPS1 NM_002764:c.405+510C>A INTRON3 Unknown significance rs372971913 This variant is a VUS because it does not have enough information. 854627 chrX:106884742:->G PRPS1 NM_002764:c.405+512_405+513insG INTRON3 Unknown significance rs35584843 This variant is a VUS because it does not have enough information. 854628 chrX:106884786:->C PRPS1 NM_002764:c.405+556_405+557insC INTRON3 Unknown significance rs34566376 This variant is a VUS because it does not have enough information. 854629 chrX:106884807:C>T PRPS1 NM_002764:c.405+