id,variation,vep_hgvs_c,vep_hgvs_p,vep_exon,vep_intron,final_pathogenicity,final_disease,vep_consequence,vep_cadd_phred,overall_max_maf,overall_max_maf_source,gene
386579,16:21689842:C>G,NM_144672.3:c.7C>G,NP_653273.3:p.Gln3Glu,1/28,\N,Unknown significance,\N,missense_variant,9.075,0.000151286,EXAC_FIN_AF,OTOA
386580,16:21689848:C>T,NM_144672.3:c.13C>T,NP_653273.3:p.Pro5Ser,1/28,\N,Likely benign,\N,missense_variant,3.304,0.0000149966,EXAC_NFE_AF,OTOA
386581,16:21689852:C>T,NM_144672.3:c.17C>T,NP_653273.3:p.Thr6Met,1/28,\N,Likely benign,\N,missense_variant,14.15,0.000227376,EVS_AA_AF,OTOA
386582,16:21689853:G>A,NM_144672.3:c.18G>A,NP_653273.3:p.Thr6=,1/28,\N,Unknown significance,\N,synonymous_variant,7.223,0.000121271,EXAC_SAS_AF,OTOA
386583,16:21689857:T>TAC,NM_144672.3:c.23_24dup,NP_653273.3:p.Ser9ThrfsTer9,1/28,\N,Unknown significance,\N,frameshift_variant,13.73,0.0000149894,EXAC_NFE_AF,OTOA
386584,16:21689859:C>T,NM_144672.3:c.24C>T,NP_653273.3:p.Tyr8=,1/28,\N,Unknown significance,\N,synonymous_variant,1.945,\N,\N,OTOA
386585,16:21689861:C>T,NM_144672.3:c.26C>T,NP_653273.3:p.Ser9Phe,1/28,\N,Likely benign,\N,missense_variant,0.006,0.00153817,EXAC_AFR_AF,OTOA
386586,16:21689863:C>T,NM_144672.3:c.28C>T,NP_653273.3:p.Leu10Phe,1/28,\N,Likely benign,\N,missense_variant,12.04,0.002,1KG_SAS_AF,OTOA
386587,16:21689870:T>G,NM_144672.3:c.35T>G,NP_653273.3:p.Leu12Arg,1/28,\N,Unknown significance,\N,missense_variant,25.1,0.000115554,EXAC_EAS_AF,OTOA
386588,16:21689879:T>A,NM_144672.3:c.44T>A,NP_653273.3:p.Phe15Tyr,1/28,\N,Benign,\N,missense_variant,23.3,0.65,OTO_JP_AF,OTOA
386589,16:21689891:G>A,NM_144672.3:c.56G>A,NP_653273.3:p.Gly19Glu,1/28,\N,Unknown significance,\N,missense_variant,12.97,0.000115554,EXAC_EAS_AF,OTOA
386590,16:21689892:A>C,NM_144672.3:c.57A>C,NP_653273.3:p.Gly19=,1/28,\N,Unknown significance,\N,synonymous_variant,0.044,0.0000149876,EXAC_NFE_AF,OTOA
386591,16:21689892:A>T,NM_144672.3:c.57A>T,NP_653273.3:p.Gly19=,1/28,\N,Unknown significance,\N,synonymous_variant,0.088,0.000231107,EXAC_EAS_AF,OTOA
386592,16:21689893:G>A,NM_144672.3:c.58G>A,NP_653273.3:p.Val20Met,1/28,\N,Unknown significance,\N,missense_variant,15.04,0.0000149876,EXAC_NFE_AF,OTOA
386593,16:21689893:G>C,NM_144672.3:c.58G>C,NP_653273.3:p.Val20Leu,1/28,\N,Unknown significance,\N,missense_variant,8.482,0.000115554,EXAC_EAS_AF,OTOA
386594,16:21689897:C>T,NM_144672.3:c.62C>T,NP_653273.3:p.Ser21Leu,1/28,\N,Likely benign,\N,missense_variant,20.9,0.000192271,EXAC_AFR_AF,OTOA
386595,16:21689898:G>A,NM_144672.3:c.63G>A,NP_653273.3:p.Ser21=,1/28,\N,Unknown significance,\N,synonymous_variant,6.14,0.0000149889,EXAC_NFE_AF,OTOA
386596,16:21689905:A>G,NM_144672.3:c.70A>G,NP_653273.3:p.Thr24Ala,1/28,\N,Likely benign,\N,missense_variant,0.001,0.000060584,EXAC_SAS_AF,OTOA
386597,16:21689928:T>G,NM_144672.3:c.91+2T>G,\N,\N,1/27,Unknown significance,\N,splice_donor_variant,23.6,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
386598,16:21689929:A>G,NM_144672.3:c.91+3A>G,\N,\N,1/27,Unknown significance,\N,splice_region_variant&intron_variant,12.99,0.0000300021,EXAC_NFE_AF,OTOA
386599,16:21689940:G>A,NM_144672.3:c.91+14G>A,\N,\N,1/27,Unknown significance,\N,intron_variant,9.402,0.0000962094,EXAC_AFR_AF,OTOA
386600,16:21689950:C>T,NM_144672.3:c.91+24C>T,\N,\N,1/27,Unknown significance,\N,intron_variant,8.298,0.00016519,EXAC_NFE_AF,OTOA
386601,16:21689956:T>C,NM_144672.3:c.91+30T>C,\N,\N,1/27,Unknown significance,\N,intron_variant,6.237,0.0000150186,EXAC_NFE_AF,OTOA
386602,16:21689958:G>A,NM_144672.3:c.91+32G>A,\N,\N,1/27,Unknown significance,\N,intron_variant,7.898,0.0000150236,EXAC_NFE_AF,OTOA
386603,16:21689965:C>A,NM_144672.3:c.91+39C>A,\N,\N,1/27,Unknown significance,\N,intron_variant,4.734,0.0000150299,EXAC_NFE_AF,OTOA
386604,16:21689969:G>GT,NM_144672.3:c.91+46dup,\N,\N,1/27,Unknown significance,\N,intron_variant,1.93,0.000385728,EXAC_AFR_AF,OTOA
386605,16:21689975:G>A,NM_144672.3:c.91+49G>A,\N,\N,1/27,Unknown significance,\N,intron_variant,5.991,0.001,1KG_EAS_AF,OTOA
386606,16:21689976:G>A,NM_144672.3:c.91+50G>A,\N,\N,1/27,Unknown significance,\N,intron_variant,5.358,0.0000301314,EXAC_NFE_AF,OTOA
386607,16:21689978:A>G,NM_144672.3:c.91+52A>G,\N,\N,1/27,Unknown significance,\N,intron_variant,3.382,0.000015068,EXAC_NFE_AF,OTOA
386608,16:21690046:T>C,NM_144672.3:c.91+120T>C,\N,\N,1/27,Unknown significance,\N,intron_variant,3.628,0.0041,1KG_SAS_AF,OTOA
386609,16:21690087:C>T,NM_144672.3:c.92-149C>T,\N,\N,1/27,Unknown significance,\N,intron_variant,0.183,0.001,1KG_SAS_AF,OTOA
386610,16:21690095:TCA>T,NM_144672.3:c.92-140_92-139del,\N,\N,1/27,Unknown significance,\N,intron_variant,7.96,0.004,1KG_EAS_AF,OTOA
386611,16:21690100:G>A,NM_144672.3:c.92-136G>A,\N,\N,1/27,Unknown significance,\N,intron_variant,1.255,\N,\N,OTOA
386612,16:21690174:A>T,NM_144672.3:c.92-62A>T,\N,\N,1/27,Benign,\N,intron_variant,1.199,0.0051,1KG_SAS_AF,OTOA
386613,16:21690178:G>A,NM_144672.3:c.92-58G>A,\N,\N,1/27,Unknown significance,\N,intron_variant,10.8,0.0008,1KG_AFR_AF,OTOA
386614,16:21690185:T>C,NM_144672.3:c.92-51T>C,\N,\N,1/27,Unknown significance,\N,intron_variant,15.58,0.000015024,EXAC_NFE_AF,OTOA
386615,16:21690190:G>A,NM_144672.3:c.92-46G>A,\N,\N,1/27,Unknown significance,\N,intron_variant,18.86,0.000756659,EXAC_FIN_AF,OTOA
386616,16:21690191:T>A,NM_144672.3:c.92-45T>A,\N,\N,1/27,Unknown significance,\N,intron_variant,20.1,0.000116279,EVS_EA_AF,OTOA
386617,16:21690192:C>G,NM_144672.3:c.92-44C>G,\N,\N,1/27,Unknown significance,\N,intron_variant,17.78,0.0000983284,EXAC_AFR_AF,OTOA
386618,16:21690214:A>G,NM_144672.3:c.92-22A>G,\N,\N,1/27,Unknown significance,\N,intron_variant,15.3,0.000545124,EXAC_SAS_AF,OTOA
386619,16:21690215:C>G,NM_144672.3:c.92-21C>G,\N,\N,1/27,Unknown significance,\N,intron_variant,14.64,0.0000450369,EXAC_NFE_AF,OTOA
386620,16:21690216:A>C,NM_144672.3:c.92-20A>C,\N,\N,1/27,Unknown significance,\N,intron_variant,12.66,0.0000150105,EXAC_NFE_AF,OTOA
386621,16:21690219:C>G,NM_144672.3:c.92-17C>G,\N,\N,1/27,Unknown significance,\N,intron_variant,14.66,0.0029,1KG_AMR_AF,OTOA
386622,16:21690225:C>A,NM_144672.3:c.92-11C>A,\N,\N,1/27,Benign,\N,intron_variant,14.38,0.0952,1KG_EAS_AF,OTOA
386623,16:21690225:C>T,NM_144672.3:c.92-11C>T,\N,\N,1/27,Unknown significance,\N,intron_variant,13.91,0.000302847,EXAC_SAS_AF,OTOA
386624,16:21690235:G>T,NM_144672.3:c.92-1G>T,\N,\N,1/27,Unknown significance,\N,splice_acceptor_variant,25.4,0.000116279,EVS_EA_AF,OTOA
386625,16:21690236:A>T,NM_144672.3:c.92A>T,NP_653273.3:p.Asp31Val,2/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,25.8,0.000014988,EXAC_NFE_AF,OTOA
386626,16:21690240:G>T,NM_144672.3:c.96G>T,NP_653273.3:p.Leu32Phe,2/28,\N,Unknown significance,\N,missense_variant,24.9,0.000346661,EXAC_EAS_AF,OTOA
386627,16:21690245:C>T,NM_144672.3:c.101C>T,NP_653273.3:p.Pro34Leu,2/28,\N,Unknown significance,\N,missense_variant,31,0.0000149858,EXAC_NFE_AF,OTOA
386628,16:21690247:T>C,NM_144672.3:c.103T>C,NP_653273.3:p.Leu35=,2/28,\N,Unknown significance,\N,synonymous_variant,3.371,0.0000863856,EXAC_AMR_AF,OTOA
386629,16:21690248:T>C,NM_144672.3:c.104T>C,NP_653273.3:p.Leu35Ser,2/28,\N,Unknown significance,\N,missense_variant,25.8,0.0000149849,EXAC_NFE_AF,OTOA
386630,16:21690252:G>A,NM_144672.3:c.108G>A,NP_653273.3:p.Leu36=,2/28,\N,Unknown significance,\N,synonymous_variant,9.162,0.0000149844,EXAC_NFE_AF,OTOA
386631,16:21690258:C>T,NM_144672.3:c.114C>T,NP_653273.3:p.Asn38=,2/28,\N,Unknown significance,\N,synonymous_variant,10.8,0.0000149844,EXAC_NFE_AF,OTOA
386632,16:21690263:C>T,NM_144672.3:c.119C>T,NP_653273.3:p.Ala40Val,2/28,\N,Likely benign,\N,missense_variant&splice_region_variant,21.7,0.001,1KG_EAS_AF,OTOA
386633,16:21690264:G>A,NM_144672.3:c.120G>A,NP_653273.3:p.Ala40=,2/28,\N,Unknown significance,\N,splice_region_variant&synonymous_variant,15.4,0.000115554,EXAC_EAS_AF,OTOA
386634,16:21690264:G>T,NM_144672.3:c.120G>T,NP_653273.3:p.Ala40=,2/28,\N,Unknown significance,\N,splice_region_variant&synonymous_variant,14.95,0.0000149849,EXAC_NFE_AF,OTOA
386635,16:21690266:T>G,NM_144672.3:c.120+2T>G,\N,\N,2/27,Unknown significance,\N,splice_donor_variant,25.4,\N,\N,OTOA
386636,16:21690268:A>G,NM_144672.3:c.120+4A>G,\N,\N,2/27,Unknown significance,\N,splice_region_variant&intron_variant,15.7,\N,\N,OTOA
386637,16:21690273:TC>T,NM_144672.3:c.120+10del,\N,\N,2/27,Unknown significance,\N,intron_variant,16.36,0.000115554,EXAC_EAS_AF,OTOA
386638,16:21690274:C>G,NM_144672.3:c.120+10C>G,\N,\N,2/27,Likely benign,\N,intron_variant,16.46,0.000764182,EXAC_NFE_AF,OTOA
386639,16:21690293:G>A,NM_144672.3:c.120+29G>A,\N,\N,2/27,Unknown significance,\N,intron_variant,13.82,0.0000863707,EXAC_AMR_AF,OTOA
386640,16:21690296:C>A,NM_144672.3:c.120+32C>A,\N,\N,2/27,Unknown significance,\N,intron_variant,15.64,0.0000605694,EXAC_SAS_AF,OTOA
386641,16:21690296:C>G,NM_144672.3:c.120+32C>G,\N,\N,2/27,Unknown significance,\N,intron_variant,14.73,\N,\N,OTOA
386642,16:21690297:C>T,NM_144672.3:c.120+33C>T,\N,\N,2/27,Unknown significance,\N,intron_variant,15.75,0.0000605694,EXAC_SAS_AF,OTOA
386643,16:21690302:A>G,NM_144672.3:c.120+38A>G,\N,\N,2/27,Unknown significance,\N,intron_variant,12.66,0.000192271,EXAC_AFR_AF,OTOA
386644,16:21690304:T>C,NM_144672.3:c.120+40T>C,\N,\N,2/27,Unknown significance,\N,intron_variant,14.45,0.001,1KG_EAS_AF,OTOA
386645,16:21690305:G>A,NM_144672.3:c.120+41G>A,\N,\N,2/27,Unknown significance,\N,intron_variant,15.15,0.0000149844,EXAC_NFE_AF,OTOA
386646,16:21690307:A>G,NM_144672.3:c.120+43A>G,\N,\N,2/27,Unknown significance,\N,intron_variant,14.88,0.000121139,EXAC_SAS_AF,OTOA
386647,16:21690312:C>A,NM_144672.3:c.121-45C>A,\N,\N,2/27,Unknown significance,\N,intron_variant,14.86,0.000302389,EXAC_FIN_AF,OTOA
386648,16:21690314:A>G,NM_144672.3:c.121-43A>G,\N,\N,2/27,Unknown significance,\N,intron_variant,14.34,0.0000605694,EXAC_SAS_AF,OTOA
386649,16:21690322:G>A,NM_144672.3:c.121-35G>A,\N,\N,2/27,Unknown significance,\N,intron_variant,0.921,0.0000605694,EXAC_SAS_AF,OTOA
386650,16:21690322:G>C,NM_144672.3:c.121-35G>C,\N,\N,2/27,Unknown significance,\N,intron_variant,0.115,0.000227376,EVS_AA_AF,OTOA
386651,16:21690329:T>C,NM_144672.3:c.121-28T>C,\N,\N,2/27,Unknown significance,\N,intron_variant,5.834,0.0008,1KG_AFR_AF,OTOA
386652,16:21690335:A>G,NM_144672.3:c.121-22A>G,\N,\N,2/27,Unknown significance,\N,intron_variant,14.15,0.000181708,EXAC_SAS_AF,OTOA
386653,16:21690337:G>A,NM_144672.3:c.121-20G>A,\N,\N,2/27,Benign,\N,intron_variant,13.33,0.0177782,EXAC_AFR_AF,OTOA
386654,16:21690338:T>C,NM_144672.3:c.121-19T>C,\N,\N,2/27,Unknown significance,\N,intron_variant,13.1,0.000227376,EVS_AA_AF,OTOA
386655,16:21690350:C>T,NM_144672.3:c.121-7C>T,\N,\N,2/27,Unknown significance,\N,splice_region_variant&intron_variant,14.51,0.0000449506,EXAC_NFE_AF,OTOA
386656,16:21690353:T>G,NM_144672.3:c.121-4T>G,\N,\N,2/27,Unknown significance,\N,splice_region_variant&intron_variant,13.19,0.000115554,EXAC_EAS_AF,OTOA
386657,16:21690367:T>C,NM_144672.3:c.131T>C,NP_653273.3:p.Ile44Thr,3/28,\N,Unknown significance,\N,missense_variant,23.8,0.0000899011,EXAC_NFE_AF,OTOA
386658,16:21690374:A>G,NM_144672.3:c.138A>G,NP_653273.3:p.Gly46=,3/28,\N,Unknown significance,\N,synonymous_variant,7.929,0.0008,1KG_AFR_AF,OTOA
386659,16:21690375:A>G,NM_144672.3:c.139A>G,NP_653273.3:p.Ser47Gly,3/28,\N,Unknown significance,\N,missense_variant,14.55,\N,\N,OTOA
386660,16:21690388:G>A,NM_144672.3:c.151+1G>A,\N,\N,3/27,Pathogenic,Hearing loss| non-syndromic| autosomal recessive,splice_donor_variant,26.3,\N,\N,OTOA
386661,16:21690391:A>G,NM_144672.3:c.151+4A>G,\N,\N,3/27,Unknown significance,\N,splice_region_variant&intron_variant,15.68,0.000115554,EXAC_EAS_AF,OTOA
386662,16:21690395:G>A,NM_144672.3:c.151+8G>A,\N,\N,3/27,Unknown significance,\N,splice_region_variant&intron_variant,4.985,0.001,1KG_SAS_AF,OTOA
386663,16:21690395:G>GC,NM_144672.3:c.151+13dup,\N,\N,3/27,Unknown significance,\N,intron_variant,\N,0.000423985,EXAC_SAS_AF,OTOA
386664,16:21690396:C>T,NM_144672.3:c.151+9C>T,\N,\N,3/27,Unknown significance,\N,intron_variant,11.46,0.000424345,EXAC_SAS_AF,OTOA
386665,16:21690403:G>A,NM_144672.3:c.151+16G>A,\N,\N,3/27,Unknown significance,\N,intron_variant,0.313,0.000348837,EVS_EA_AF,OTOA
386666,16:21690405:T>A,NM_144672.3:c.151+18T>A,\N,\N,3/27,Unknown significance,\N,intron_variant,3.881,0.000227376,EVS_AA_AF,OTOA
386667,16:21690430:T>G,NM_144672.3:c.151+43T>G,\N,\N,3/27,Unknown significance,\N,intron_variant,18.48,0.000014984,EXAC_NFE_AF,OTOA
386668,16:21690434:A>G,NM_144672.3:c.151+47A>G,\N,\N,3/27,Unknown significance,\N,intron_variant,15.7,0.000192197,EXAC_AFR_AF,OTOA
386669,16:21690476:G>A,NM_144672.3:c.152-29G>A,\N,\N,3/27,Unknown significance,\N,intron_variant,20.2,0.0000299697,EXAC_NFE_AF,OTOA
386670,16:21690481:C>A,NM_144672.3:c.152-24C>A,\N,\N,3/27,Unknown significance,\N,intron_variant,21.7,0.0000149862,EXAC_NFE_AF,OTOA
386671,16:21690487:A>G,NM_144672.3:c.152-18A>G,\N,\N,3/27,Unknown significance,\N,intron_variant,17.72,0.00110132,EXAC_OTH_AF,OTOA
386672,16:21690497:C>T,NM_144672.3:c.152-8C>T,\N,\N,3/27,Unknown significance,\N,splice_region_variant&intron_variant,16.41,0.000121124,EXAC_SAS_AF,OTOA
386673,16:21690511:T>C,NM_144672.3:c.158T>C,NP_653273.3:p.Leu53Pro,4/28,\N,Unknown significance,\N,missense_variant,27.6,0.0000149867,EXAC_NFE_AF,OTOA
386674,16:21690522:C>T,NM_144672.3:c.169C>T,NP_653273.3:p.Gln57Ter,4/28,\N,Unknown significance,\N,stop_gained,39,0.0000149898,EXAC_NFE_AF,OTOA
386675,16:21690524:G>C,NM_144672.3:c.171G>C,NP_653273.3:p.Gln57His,4/28,\N,Likely benign,\N,missense_variant,13.75,0.003125,OTO_CO_AF,OTOA
386676,16:21690526:T>C,NM_144672.3:c.173T>C,NP_653273.3:p.Phe58Ser,4/28,\N,Unknown significance,\N,missense_variant,28.1,0.0000149916,EXAC_NFE_AF,OTOA
386677,16:21690541:C>G,NM_144672.3:c.179+9C>G,\N,\N,4/27,Unknown significance,\N,intron_variant,10.98,0.000172801,EXAC_AMR_AF,OTOA
386678,16:21690542:C>G,NM_144672.3:c.179+10C>G,\N,\N,4/27,Unknown significance,\N,intron_variant,11.62,\N,\N,OTOA
386679,16:21690559:G>A,NM_144672.3:c.179+27G>A,\N,\N,4/27,Benign,\N,intron_variant,13.58,0.7475,OTO_JP_AF,OTOA
386680,16:21690572:T>A,NM_144672.3:c.179+40T>A,\N,\N,4/27,Unknown significance,\N,intron_variant,16.69,0.001,1KG_EAS_AF,OTOA
386681,16:21690578:A>G,NM_144672.3:c.179+46A>G,\N,\N,4/27,Unknown significance,\N,intron_variant,15.15,0.000206697,EXAC_AFR_AF,OTOA
386682,16:21690579:T>G,NM_144672.3:c.179+47T>G,\N,\N,4/27,Unknown significance,\N,intron_variant,14.03,0.000015174,EXAC_NFE_AF,OTOA
386683,16:21690602:T>C,NM_144672.3:c.179+70T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,2.964,0.0015,1KG_AFR_AF,OTOA
386684,16:21690649:T>C,NM_144672.3:c.179+117T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,0.851,0.001,1KG_EAS_AF,OTOA
386685,16:21690678:C>T,NM_144672.3:c.179+146C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,2.816,\N,\N,OTOA
386686,16:21690688:C>A,NM_144672.3:c.179+156C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,2.695,0.001,1KG_EAS_AF,OTOA
386687,16:21690689:G>A,NM_144672.3:c.179+157G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,1.251,\N,\N,OTOA
386688,16:21690724:A>AT,NM_144672.3:c.179+200dup,\N,\N,4/27,Unknown significance,\N,intron_variant,0.233,0.0023,1KG_AFR_AF,OTOA
386689,16:21690746:G>A,NM_144672.3:c.179+214G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,1.222,0.001,1KG_SAS_AF,OTOA
386690,16:21690753:G>A,NM_144672.3:c.179+221G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,0.163,0.0015,1KG_AFR_AF,OTOA
386691,16:21690754:C>T,NM_144672.3:c.179+222C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,1.482,0.001,1KG_EUR_AF,OTOA
386692,16:21690785:C>T,NM_144672.3:c.179+253C>T,\N,\N,4/27,Benign,\N,intron_variant,2.111,0.4402,1KG_AFR_AF,OTOA
386693,16:21690786:T>C,NM_144672.3:c.179+254T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,1.563,\N,\N,OTOA
386694,16:21690818:G>A,NM_144672.3:c.179+286G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,1.574,0.0008,1KG_AFR_AF,OTOA
386695,16:21690846:C>T,NM_144672.3:c.179+314C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,9.641,\N,\N,OTOA
386696,16:21690892:A>G,NM_144672.3:c.179+360A>G,\N,\N,4/27,Unknown significance,\N,intron_variant,3.573,0.0008,1KG_AFR_AF,OTOA
386697,16:21690917:G>A,NM_144672.3:c.179+385G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,2.682,\N,\N,OTOA
386698,16:21690917:G>T,NM_144672.3:c.179+385G>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.928,0.0008,1KG_AFR_AF,OTOA
386699,16:21690930:T>G,NM_144672.3:c.179+398T>G,\N,\N,4/27,Unknown significance,\N,intron_variant,4.092,0.001,1KG_EUR_AF,OTOA
386700,16:21690972:G>A,NM_144672.3:c.179+440G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,0.022,0.0008,1KG_AFR_AF,OTOA
386701,16:21690991:G>A,NM_144672.3:c.179+459G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,0.711,\N,\N,OTOA
386702,16:21691001:C>G,NM_144672.3:c.179+469C>G,\N,\N,4/27,Unknown significance,\N,intron_variant,0.237,\N,\N,OTOA
386703,16:21691001:C>T,NM_144672.3:c.179+469C>T,\N,\N,4/27,Benign,\N,intron_variant,0.425,0.013,1KG_AMR_AF,OTOA
386704,16:21691016:G>A,NM_144672.3:c.179+484G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,0.237,\N,\N,OTOA
386705,16:21691021:C>T,NM_144672.3:c.179+489C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.295,0.0008,1KG_AFR_AF,OTOA
386706,16:21691042:T>C,NM_144672.3:c.179+510T>C,\N,\N,4/27,Benign,\N,intron_variant,3.248,0.1165,1KG_AFR_AF,OTOA
386707,16:21691077:C>T,NM_144672.3:c.179+545C>T,\N,\N,4/27,Benign,\N,intron_variant,4.426,0.4402,1KG_AFR_AF,OTOA
386708,16:21691078:G>T,NM_144672.3:c.179+546G>T,\N,\N,4/27,Unknown significance,\N,intron_variant,2.613,0.0014,1KG_AMR_AF,OTOA
386709,16:21691081:T>C,NM_144672.3:c.179+549T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,4.697,0.0008,1KG_AFR_AF,OTOA
386710,16:21691127:C>A,NM_144672.3:c.179+595C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,4.249,0.001,1KG_SAS_AF,OTOA
386711,16:21691148:A>T,NM_144672.3:c.179+616A>T,\N,\N,4/27,Benign,\N,intron_variant,5.945,0.0109,1KG_EUR_AF,OTOA
386712,16:21691151:A>G,NM_144672.3:c.179+619A>G,\N,\N,4/27,Unknown significance,\N,intron_variant,6.314,\N,\N,OTOA
386713,16:21691208:C>A,NM_144672.3:c.179+676C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,4.295,0.001,1KG_SAS_AF,OTOA
386714,16:21691231:T>C,NM_144672.3:c.179+699T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,2.171,0.0008,1KG_AFR_AF,OTOA
386715,16:21691290:G>A,NM_144672.3:c.179+758G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,4.771,\N,\N,OTOA
386716,16:21691293:C>G,NM_144672.3:c.179+761C>G,\N,\N,4/27,Unknown significance,\N,intron_variant,1.4,0.001,1KG_SAS_AF,OTOA
386717,16:21691295:A>G,NM_144672.3:c.179+763A>G,\N,\N,4/27,Unknown significance,\N,intron_variant,3.832,0.0008,1KG_AFR_AF,OTOA
386718,16:21691309:C>T,NM_144672.3:c.179+777C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.605,0.001,1KG_SAS_AF,OTOA
386719,16:21691337:G>C,NM_144672.3:c.179+805G>C,\N,\N,4/27,Unknown significance,\N,intron_variant,0.328,0.0008,1KG_AFR_AF,OTOA
386720,16:21691352:C>T,NM_144672.3:c.179+820C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,2.873,\N,\N,OTOA
386721,16:21691353:G>A,NM_144672.3:c.179+821G>A,\N,\N,4/27,Benign,\N,intron_variant,4.164,0.0227,1KG_AFR_AF,OTOA
386722,16:21691387:G>C,NM_144672.3:c.179+855G>C,\N,\N,4/27,Unknown significance,\N,intron_variant,1.015,\N,\N,OTOA
386723,16:21691428:TC>T,NM_144672.3:c.179+898del,\N,\N,4/27,Benign,\N,intron_variant,0.442,0.0072,1KG_AMR_AF,OTOA
386724,16:21691461:T>G,NM_144672.3:c.179+929T>G,\N,\N,4/27,Benign,\N,intron_variant,5.439,0.0083,1KG_AFR_AF,OTOA
386725,16:21691471:C>A,NM_144672.3:c.179+939C>A,\N,\N,4/27,Benign,\N,intron_variant,1.41,0.4402,1KG_AFR_AF,OTOA
386726,16:21691504:T>C,NM_144672.3:c.179+972T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,5.943,\N,\N,OTOA
386727,16:21691505:T>C,NM_144672.3:c.179+973T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,5.721,\N,\N,OTOA
386728,16:21691505:T>TATCC,NM_144672.3:c.179+1001_179+1004dup,\N,\N,4/27,Unknown significance,\N,intron_variant,3.995,\N,\N,OTOA
386729,16:21691505:T>TATCCATCC,NM_144672.3:c.179+997_179+1004dup,\N,\N,4/27,Unknown significance,\N,intron_variant,3.308,\N,\N,OTOA
386730,16:21691505:T>TATCCATCCATCC,NM_144672.3:c.179+993_179+1004dup,\N,\N,4/27,Unknown significance,\N,intron_variant,2.657,\N,\N,OTOA
386731,16:21691505:T>TATCCATCCATCCATCC,NM_144672.3:c.179+989_179+1004dup,\N,\N,4/27,Unknown significance,\N,intron_variant,2.072,\N,\N,OTOA
386732,16:21691505:T>TATCCATCCATCCATCCATCC,NM_144672.3:c.179+985_179+1004dup,\N,\N,4/27,Unknown significance,\N,intron_variant,1.577,\N,\N,OTOA
386733,16:21691510:A>G,NM_144672.3:c.179+978A>G,\N,\N,4/27,Unknown significance,\N,intron_variant,1.343,0.001,1KG_EAS_AF,OTOA
386734,16:21691530:A>C,NM_144672.3:c.179+998A>C,\N,\N,4/27,Unknown significance,\N,intron_variant,0.866,0.001,1KG_EUR_AF,OTOA
386735,16:21691555:C>A,NM_144672.3:c.179+1023C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,2.191,0.001,1KG_SAS_AF,OTOA
386736,16:21691561:G>A,NM_144672.3:c.179+1029G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,0.141,0.0014,1KG_AMR_AF,OTOA
386737,16:21691570:C>T,NM_144672.3:c.179+1038C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,2.604,0.001,1KG_SAS_AF,OTOA
386738,16:21691577:A>G,NM_144672.3:c.179+1045A>G,\N,\N,4/27,Benign,\N,intron_variant,1.872,0.1938,1KG_EUR_AF,OTOA
386739,16:21691587:G>C,NM_144672.3:c.179+1055G>C,\N,\N,4/27,Benign,\N,intron_variant,0.227,0.4569,1KG_AFR_AF,OTOA
386740,16:21691589:C>T,NM_144672.3:c.179+1057C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,1.109,0.001,1KG_SAS_AF,OTOA
386741,16:21691631:G>A,NM_144672.3:c.179+1099G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,1.216,\N,\N,OTOA
386742,16:21691665:C>T,NM_144672.3:c.179+1133C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.563,0.0038,1KG_AFR_AF,OTOA
386743,16:21691676:T>C,NM_144672.3:c.179+1144T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,1.997,0.001,1KG_EUR_AF,OTOA
386744,16:21691701:G>C,NM_144672.3:c.179+1169G>C,\N,\N,4/27,Unknown significance,\N,intron_variant,0.362,\N,\N,OTOA
386745,16:21691705:C>T,NM_144672.3:c.179+1173C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,1.764,0.002,1KG_EAS_AF,OTOA
386746,16:21691738:G>A,NM_144672.3:c.179+1206G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,3.541,0.001,1KG_SAS_AF,OTOA
386747,16:21691757:C>T,NM_144672.3:c.179+1225C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,1.038,0.001,1KG_SAS_AF,OTOA
386748,16:21691759:C>T,NM_144672.3:c.179+1227C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.762,0.0041,1KG_SAS_AF,OTOA
386749,16:21691760:G>A,NM_144672.3:c.179+1228G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,0.15,\N,\N,OTOA
386750,16:21691764:G>C,NM_144672.3:c.179+1232G>C,\N,\N,4/27,Unknown significance,\N,intron_variant,0.459,\N,\N,OTOA
386751,16:21691771:G>A,NM_144672.3:c.179+1239G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,2.058,0.0008,1KG_AFR_AF,OTOA
386752,16:21691798:G>A,NM_144672.3:c.180-1261G>A,\N,\N,4/27,Benign,\N,intron_variant,4.724,0.0144,1KG_AFR_AF,OTOA
386753,16:21691813:C>T,NM_144672.3:c.180-1246C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,5.046,\N,\N,OTOA
386754,16:21691833:G>A,NM_144672.3:c.180-1226G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,0.056,\N,\N,OTOA
386755,16:21691835:A>AAAAC,NM_144672.3:c.180-1204_180-1201dup,\N,\N,4/27,Unknown significance,\N,intron_variant,0.235,\N,\N,OTOA
386756,16:21691835:AAAAC>A,NM_144672.3:c.180-1204_180-1201del,\N,\N,4/27,Unknown significance,\N,intron_variant,1.756,\N,\N,OTOA
386757,16:21691835:AAAACAAAC>A,NM_144672.3:c.180-1208_180-1201del,\N,\N,4/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
386758,16:21691867:C>G,NM_144672.3:c.180-1192C>G,\N,\N,4/27,Unknown significance,\N,intron_variant,0.707,\N,\N,OTOA
386759,16:21691945:A>G,NM_144672.3:c.180-1114A>G,\N,\N,4/27,Benign,\N,intron_variant,2.487,0.4576,1KG_AFR_AF,OTOA
386760,16:21691953:C>T,NM_144672.3:c.180-1106C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,1.547,\N,\N,OTOA
386761,16:21691954:G>A,NM_144672.3:c.180-1105G>A,\N,\N,4/27,Benign,\N,intron_variant,0.042,0.006,1KG_EUR_AF,OTOA
386762,16:21691975:C>T,NM_144672.3:c.180-1084C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,1.001,0,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,OTOA
386763,16:21691982:C>T,NM_144672.3:c.180-1077C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.054,\N,\N,OTOA
386764,16:21691983:G>A,NM_144672.3:c.180-1076G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,1.357,0.004,1KG_EAS_AF,OTOA
386765,16:21692031:G>T,NM_144672.3:c.180-1028G>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.799,0.001,1KG_EAS_AF,OTOA
386766,16:21692032:G>T,NM_144672.3:c.180-1027G>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.575,0.001,1KG_SAS_AF,OTOA
386767,16:21692047:G>A,NM_144672.3:c.180-1012G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,0.044,0.0014,1KG_AMR_AF,OTOA
386768,16:21692089:G>A,NM_144672.3:c.180-970G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,1.837,0.001,1KG_EUR_AF,OTOA
386769,16:21692091:T>C,NM_144672.3:c.180-968T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,1.893,\N,\N,OTOA
386770,16:21692098:T>C,NM_144672.3:c.180-961T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,0.236,0.0008,1KG_AFR_AF,OTOA
386771,16:21692105:C>T,NM_144672.3:c.180-954C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.169,0.0014,1KG_AMR_AF,OTOA
386772,16:21692106:G>A,NM_144672.3:c.180-953G>A,\N,\N,4/27,Benign,\N,intron_variant,0.27,0.0516,1KG_EAS_AF,OTOA
386773,16:21692116:G>A,NM_144672.3:c.180-943G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,2.708,\N,\N,OTOA
386774,16:21692130:C>A,NM_144672.3:c.180-929C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,2.226,\N,\N,OTOA
386775,16:21692131:A>G,NM_144672.3:c.180-928A>G,\N,\N,4/27,Unknown significance,\N,intron_variant,0.636,\N,\N,OTOA
386776,16:21692168:T>A,NM_144672.3:c.180-891T>A,\N,\N,4/27,Unknown significance,\N,intron_variant,3.705,\N,\N,OTOA
386777,16:21692168:T>C,NM_144672.3:c.180-891T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,1.129,0.001,1KG_SAS_AF,OTOA
386778,16:21692174:C>A,NM_144672.3:c.180-885C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,0.221,\N,\N,OTOA
386779,16:21692175:A>C,NM_144672.3:c.180-884A>C,\N,\N,4/27,Unknown significance,\N,intron_variant,0.79,\N,\N,OTOA
386780,16:21692191:A>G,NM_144672.3:c.180-868A>G,\N,\N,4/27,Benign,\N,intron_variant,1.119,0.0082,1KG_SAS_AF,OTOA
386781,16:21692208:A>G,NM_144672.3:c.180-851A>G,\N,\N,4/27,Unknown significance,\N,intron_variant,0.606,\N,\N,OTOA
386782,16:21692241:C>T,NM_144672.3:c.180-818C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.993,0.0014,1KG_AMR_AF,OTOA
386783,16:21692247:T>A,NM_144672.3:c.180-812T>A,\N,\N,4/27,Unknown significance,\N,intron_variant,6.443,\N,\N,OTOA
386784,16:21692256:T>G,NM_144672.3:c.180-803T>G,\N,\N,4/27,Unknown significance,\N,intron_variant,2.495,0.001,1KG_SAS_AF,OTOA
386785,16:21692311:G>A,NM_144672.3:c.180-748G>A,\N,\N,4/27,Benign,\N,intron_variant,7.712,0.0439,1KG_AFR_AF,OTOA
386786,16:21692315:C>A,NM_144672.3:c.180-744C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,2.407,\N,\N,OTOA
386787,16:21692338:C>T,NM_144672.3:c.180-721C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.981,0.001,1KG_SAS_AF,OTOA
386788,16:21692393:C>T,NM_144672.3:c.180-666C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,7.107,0.0008,1KG_AFR_AF,OTOA
386789,16:21692399:A>C,NM_144672.3:c.180-660A>C,\N,\N,4/27,Unknown significance,\N,intron_variant,1.548,\N,\N,OTOA
386790,16:21692400:CTA>C,NM_144672.3:c.180-657_180-656del,\N,\N,4/27,Unknown significance,\N,intron_variant,3.382,0.002,1KG_EUR_AF,OTOA
386791,16:21692415:C>A,NM_144672.3:c.180-644C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,6.649,\N,\N,OTOA
386792,16:21692417:C>T,NM_144672.3:c.180-642C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,5.583,\N,\N,OTOA
386793,16:21692440:T>G,NM_144672.3:c.180-619T>G,\N,\N,4/27,Unknown significance,\N,intron_variant,2.756,0.001,1KG_EAS_AF,OTOA
386794,16:21692477:T>C,NM_144672.3:c.180-582T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,1.659,0.002,1KG_EAS_AF,OTOA
386795,16:21692504:G>A,NM_144672.3:c.180-555G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,1.137,\N,\N,OTOA
386796,16:21692591:A>G,NM_144672.3:c.180-468A>G,\N,\N,4/27,Unknown significance,\N,intron_variant,0.279,0.0008,1KG_AFR_AF,OTOA
386797,16:21692654:G>A,NM_144672.3:c.180-405G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,6.42,\N,\N,OTOA
386798,16:21692664:T>C,NM_144672.3:c.180-395T>C,\N,\N,4/27,Benign,\N,intron_variant,8.542,0.9917,1KG_AFR_AF,OTOA
386799,16:21692701:C>A,NM_144672.3:c.180-358C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,13.7,0.0041,1KG_SAS_AF,OTOA
386800,16:21692714:C>G,NM_144672.3:c.180-345C>G,\N,\N,4/27,Unknown significance,\N,intron_variant,12.05,\N,\N,OTOA
386801,16:21692723:G>A,NM_144672.3:c.180-336G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,14.77,0.001,1KG_SAS_AF,OTOA
386802,16:21692759:C>G,NM_144672.3:c.180-300C>G,\N,\N,4/27,Unknown significance,\N,intron_variant,4.305,\N,\N,OTOA
386803,16:21692816:A>T,NM_144672.3:c.180-243A>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.572,\N,\N,OTOA
386804,16:21692852:C>T,NM_144672.3:c.180-207C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,0.964,0.001,1KG_EUR_AF,OTOA
386805,16:21692853:G>A,NM_144672.3:c.180-206G>A,\N,\N,4/27,Unknown significance,\N,intron_variant,0.153,\N,\N,OTOA
386806,16:21692865:C>T,NM_144672.3:c.180-194C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,2.44,0.001,1KG_SAS_AF,OTOA
386807,16:21692900:A>G,NM_144672.3:c.180-159A>G,\N,\N,4/27,Unknown significance,\N,intron_variant,1.563,0.0014,1KG_AMR_AF,OTOA
386808,16:21692906:G>GAAAGA,NM_144672.3:c.180-142_180-138dup,\N,\N,4/27,Unknown significance,\N,intron_variant,0.244,0.002,1KG_SAS_AF,OTOA
386809,16:21692954:C>A,NM_144672.3:c.180-105C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,4.005,0.001,1KG_EAS_AF,OTOA
386810,16:21692993:C>G,NM_144672.3:c.180-66C>G,\N,\N,4/27,Unknown significance,\N,intron_variant,4.214,0.002,1KG_EUR_AF,OTOA
386811,16:21693012:A>T,NM_144672.3:c.180-47A>T,\N,\N,4/27,Unknown significance,\N,intron_variant,3.303,0.001,1KG_SAS_AF,OTOA
386812,16:21693016:G>C,NM_144672.3:c.180-43G>C,\N,\N,4/27,Unknown significance,\N,intron_variant,1.769,0.000236798,EXAC_EAS_AF,OTOA
386813,16:21693033:C>A,NM_144672.3:c.180-26C>A,\N,\N,4/27,Unknown significance,\N,intron_variant,5.695,0.001,1KG_EAS_AF,OTOA
386814,16:21693044:T>C,NM_144672.3:c.180-15T>C,\N,\N,4/27,Unknown significance,\N,intron_variant,6.38,0.000115821,EXAC_EAS_AF,OTOA
386815,16:21693047:C>T,NM_144672.3:c.180-12C>T,\N,\N,4/27,Unknown significance,\N,intron_variant,8.539,0.000262055,EXAC_AMR_AF,OTOA
386816,16:21693053:C>T,NM_144672.3:c.180-6C>T,\N,\N,4/27,Unknown significance,\N,splice_region_variant&intron_variant,2.724,0.0000611023,EXAC_SAS_AF,OTOA
386817,16:21693060:T>G,NM_144672.3:c.181T>G,NP_653273.3:p.Ser61Ala,5/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,7.291,0.000116279,EVS_EA_AF,OTOA
386818,16:21693066:G>A,NM_144672.3:c.187G>A,NP_653273.3:p.Val63Met,5/28,\N,Likely benign,\N,missense_variant,3.774,0.000121551,EXAC_SAS_AF,OTOA
386819,16:21693066:G>T,NM_144672.3:c.187G>T,NP_653273.3:p.Val63Leu,5/28,\N,Likely benign,\N,missense_variant,0.257,0.0000299985,EXAC_NFE_AF,OTOA
386820,16:21693073:C>A,NM_144672.3:c.194C>A,NP_653273.3:p.Thr65Lys,5/28,\N,Unknown significance,\N,missense_variant,26.4,0.000288462,EXAC_AFR_AF,OTOA
386821,16:21693073:C>T,NM_144672.3:c.194C>T,NP_653273.3:p.Thr65Met,5/28,\N,Unknown significance,\N,missense_variant,25.6,0.002,1KG_SAS_AF,OTOA
386822,16:21693093:G>A,NM_144672.3:c.214G>A,NP_653273.3:p.Val72Ile,5/28,\N,Likely benign,\N,missense_variant,9.214,0.000116279,EVS_EA_AF,OTOA
386823,16:21693105:C>G,NM_144672.3:c.226C>G,NP_653273.3:p.Leu76Val,5/28,\N,Unknown significance,\N,missense_variant,24.9,0.000029976,EXAC_NFE_AF,OTOA
386824,16:21693106:T>C,NM_144672.3:c.227T>C,NP_653273.3:p.Leu76Pro,5/28,\N,Unknown significance,\N,missense_variant,26,\N,\N,OTOA
386825,16:21693114:C>T,NM_144672.3:c.235C>T,NP_653273.3:p.Arg79Trp,5/28,\N,Likely benign,\N,missense_variant,23.6,0.0000606061,EXAC_SAS_AF,OTOA
386826,16:21693115:G>A,NM_144672.3:c.236G>A,NP_653273.3:p.Arg79Gln,5/28,\N,Likely benign,\N,missense_variant,10.93,0.00365244,EXAC_AFR_AF,OTOA
386827,16:21693116:G>C,NM_144672.3:c.237G>C,NP_653273.3:p.Arg79=,5/28,\N,Unknown significance,\N,synonymous_variant,5.558,0.0000960984,EXAC_AFR_AF,OTOA
386828,16:21693123:G>A,NM_144672.3:c.244G>A,NP_653273.3:p.Ala82Thr,5/28,\N,Likely benign,\N,missense_variant,4.31,0.00005997,EXAC_NFE_AF,OTOA
386829,16:21693124:C>A,NM_144672.3:c.245C>A,NP_653273.3:p.Ala82Asp,5/28,\N,Likely benign,\N,missense_variant,18.88,0.000014993,EXAC_NFE_AF,OTOA
386830,16:21693125:C>G,NM_144672.3:c.246C>G,NP_653273.3:p.Ala82=,5/28,\N,Unknown significance,\N,synonymous_variant,14.94,0.000115554,EXAC_EAS_AF,OTOA
386831,16:21693129:A>C,NM_144672.3:c.250A>C,NP_653273.3:p.Thr84Pro,5/28,\N,Unknown significance,\N,missense_variant,26.2,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
386832,16:21693134:C>T,NM_144672.3:c.255C>T,NP_653273.3:p.Ile85=,5/28,\N,Unknown significance,\N,synonymous_variant,13.34,0.000384541,EXAC_AFR_AF,OTOA
386833,16:21693140:C>A,NM_144672.3:c.261C>A,NP_653273.3:p.Ser87Arg,5/28,\N,Unknown significance,\N,missense_variant,32,0.000151791,EXAC_FIN_AF,OTOA
386834,16:21693141:C>T,NM_144672.3:c.262C>T,NP_653273.3:p.Leu88=,5/28,\N,Unknown significance,\N,synonymous_variant,14.92,0.0000961908,EXAC_AFR_AF,OTOA
386835,16:21693158:A>G,NM_144672.3:c.267+12A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,16.67,0.00011558,EXAC_EAS_AF,OTOA
386836,16:21693163:C>T,NM_144672.3:c.267+17C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,10.94,0.000121966,EXAC_SAS_AF,OTOA
386837,16:21693164:A>T,NM_144672.3:c.267+18A>T,\N,\N,5/27,Unknown significance,\N,intron_variant,8.412,0.0000150362,EXAC_NFE_AF,OTOA
386838,16:21693165:T>A,NM_144672.3:c.267+19T>A,\N,\N,5/27,Unknown significance,\N,intron_variant,5.995,0.0000150399,EXAC_NFE_AF,OTOA
386839,16:21693172:G>GT,NM_144672.3:c.267+28dup,\N,\N,5/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
386840,16:21693191:G>A,NM_144672.3:c.267+45G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,8.931,0.000116523,EXAC_EAS_AF,OTOA
386841,16:21693197:G>A,NM_144672.3:c.267+51G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,9.026,0.000117288,EXAC_EAS_AF,OTOA
386842,16:21693217:A>G,NM_144672.3:c.267+71A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,3.408,0.001,1KG_SAS_AF,OTOA
386843,16:21693264:G>A,NM_144672.3:c.267+118G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,4.311,\N,\N,OTOA
386844,16:21693271:G>C,NM_144672.3:c.267+125G>C,\N,\N,5/27,Unknown significance,\N,intron_variant,0.194,\N,\N,OTOA
386845,16:21693277:T>C,NM_144672.3:c.267+131T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,0.862,0,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,OTOA
386846,16:21693298:A>G,NM_144672.3:c.267+152A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,3.007,0.0008,1KG_AFR_AF,OTOA
386847,16:21693314:C>T,NM_144672.3:c.267+168C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,6.265,0.001,1KG_SAS_AF,OTOA
386848,16:21693322:C>T,NM_144672.3:c.267+176C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,7.402,\N,\N,OTOA
386849,16:21693327:T>C,NM_144672.3:c.267+181T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,7.805,\N,\N,OTOA
386850,16:21693343:G>C,NM_144672.3:c.267+197G>C,\N,\N,5/27,Unknown significance,\N,intron_variant,0.397,0.0008,1KG_AFR_AF,OTOA
386851,16:21693388:C>A,NM_144672.3:c.267+242C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,6.367,\N,\N,OTOA
386852,16:21693417:A>G,NM_144672.3:c.267+271A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,1.592,0.0008,1KG_AFR_AF,OTOA
386853,16:21693433:G>A,NM_144672.3:c.267+287G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.732,0.001,1KG_SAS_AF,OTOA
386854,16:21693437:A>C,NM_144672.3:c.267+291A>C,\N,\N,5/27,Unknown significance,\N,intron_variant,7.041,\N,\N,OTOA
386855,16:21693536:T>C,NM_144672.3:c.267+390T>C,\N,\N,5/27,Benign,\N,intron_variant,0.946,0.0144,1KG_AFR_AF,OTOA
386856,16:21693558:T>C,NM_144672.3:c.267+412T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,1.055,0.003,1KG_EUR_AF,OTOA
386857,16:21693565:G>A,NM_144672.3:c.267+419G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,5.954,0.0038,1KG_AFR_AF,OTOA
386858,16:21693585:C>T,NM_144672.3:c.267+439C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.43,0.0008,1KG_AFR_AF,OTOA
386859,16:21693589:C>T,NM_144672.3:c.267+443C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.394,\N,\N,OTOA
386860,16:21693592:G>A,NM_144672.3:c.267+446G>A,\N,\N,5/27,Benign,\N,intron_variant,3.338,0.0129,1KG_AFR_AF,OTOA
386861,16:21693623:G>A,NM_144672.3:c.267+477G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.333,0.001,1KG_SAS_AF,OTOA
386862,16:21693632:C>T,NM_144672.3:c.267+486C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.434,\N,\N,OTOA
386863,16:21693647:C>A,NM_144672.3:c.267+501C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,3.236,0.001,1KG_EUR_AF,OTOA
386864,16:21693648:G>A,NM_144672.3:c.267+502G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.909,0.0008,1KG_AFR_AF,OTOA
386865,16:21693653:T>C,NM_144672.3:c.267+507T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,1.89,0.001,1KG_SAS_AF,OTOA
386866,16:21693680:A>G,NM_144672.3:c.267+534A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,0.489,0.0008,1KG_AFR_AF,OTOA
386867,16:21693695:A>G,NM_144672.3:c.267+549A>G,\N,\N,5/27,Benign,\N,intron_variant,1.929,0.0317,1KG_EAS_AF,OTOA
386868,16:21693709:C>T,NM_144672.3:c.267+563C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.045,0.0008,1KG_AFR_AF,OTOA
386869,16:21693717:G>A,NM_144672.3:c.267+571G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.547,0.0008,1KG_AFR_AF,OTOA
386870,16:21693723:T>C,NM_144672.3:c.267+577T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,3.004,0.001,1KG_EAS_AF,OTOA
386871,16:21693728:C>T,NM_144672.3:c.267+582C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,1.239,0.0008,1KG_AFR_AF,OTOA
386872,16:21693762:G>A,NM_144672.3:c.267+616G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,0.34,\N,\N,OTOA
386873,16:21693821:A>G,NM_144672.3:c.267+675A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,4.634,0.001,1KG_EUR_AF,OTOA
386874,16:21693824:T>C,NM_144672.3:c.267+678T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,4.082,\N,\N,OTOA
386875,16:21693838:A>G,NM_144672.3:c.267+692A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,3.435,0.0008,1KG_AFR_AF,OTOA
386876,16:21693874:A>G,NM_144672.3:c.267+728A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,1.24,0.001,1KG_EAS_AF,OTOA
386877,16:21693902:G>A,NM_144672.3:c.267+756G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,0.267,\N,\N,OTOA
386878,16:21693921:C>T,NM_144672.3:c.267+775C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,0.732,\N,\N,OTOA
386879,16:21693922:G>A,NM_144672.3:c.267+776G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,2.891,\N,\N,OTOA
386880,16:21693957:A>G,NM_144672.3:c.267+811A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,4.519,\N,\N,OTOA
386881,16:21694006:T>C,NM_144672.3:c.267+860T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,0.411,0.0029,1KG_AMR_AF,OTOA
386882,16:21694015:A>G,NM_144672.3:c.267+869A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,0.527,\N,\N,OTOA
386883,16:21694019:C>A,NM_144672.3:c.267+873C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.462,0.0008,1KG_AFR_AF,OTOA
386884,16:21694078:G>A,NM_144672.3:c.267+932G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.85,0.001,1KG_SAS_AF,OTOA
386885,16:21694092:C>CATA,NM_144672.3:c.267+947_267+949dup,\N,\N,5/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
386886,16:21694092:CATA>C,NM_144672.3:c.267+947_267+949del,\N,\N,5/27,Benign,\N,intron_variant,4.785,0.357,1KG_AFR_AF,OTOA
386887,16:21694095:A>T,NM_144672.3:c.267+949A>T,\N,\N,5/27,Benign,\N,intron_variant,0.489,0.0151,1KG_AFR_AF,OTOA
386888,16:21694112:A>G,NM_144672.3:c.267+966A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,4.573,\N,\N,OTOA
386889,16:21694236:A>G,NM_144672.3:c.267+1090A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,5.917,\N,\N,OTOA
386890,16:21694238:A>G,NM_144672.3:c.267+1092A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,2.01,\N,\N,OTOA
386891,16:21694296:C>T,NM_144672.3:c.267+1150C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,4.427,\N,\N,OTOA
386892,16:21694358:C>T,NM_144672.3:c.267+1212C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,0.362,0.0029,1KG_AMR_AF,OTOA
386893,16:21694391:T>C,NM_144672.3:c.267+1245T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,1.74,0.001,1KG_EUR_AF,OTOA
386894,16:21694398:A>T,NM_144672.3:c.267+1252A>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.554,0.0008,1KG_AFR_AF,OTOA
386895,16:21694420:G>A,NM_144672.3:c.267+1274G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,0.969,0.0031,1KG_SAS_AF,OTOA
386896,16:21694449:G>T,NM_144672.3:c.267+1303G>T,\N,\N,5/27,Unknown significance,\N,intron_variant,0.35,0.002,1KG_EAS_AF,OTOA
386897,16:21694451:G>A,NM_144672.3:c.267+1305G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.081,0.0008,1KG_AFR_AF,OTOA
386898,16:21694463:G>A,NM_144672.3:c.267+1317G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,3.402,0.001,1KG_SAS_AF,OTOA
386899,16:21694473:G>T,NM_144672.3:c.267+1327G>T,\N,\N,5/27,Unknown significance,\N,intron_variant,0.353,\N,\N,OTOA
386900,16:21694515:G>A,NM_144672.3:c.267+1369G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.717,\N,\N,OTOA
386901,16:21694549:T>C,NM_144672.3:c.267+1403T>C,\N,\N,5/27,Benign,\N,intron_variant,0.585,0.0164,1KG_SAS_AF,OTOA
386902,16:21694549:TAG>T,NM_144672.3:c.267+1407_267+1408del,\N,\N,5/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
386903,16:21694570:A>G,NM_144672.3:c.267+1424A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,0.54,0.001,1KG_EAS_AF,OTOA
386904,16:21694576:C>T,NM_144672.3:c.267+1430C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,1.602,\N,\N,OTOA
386905,16:21694626:C>T,NM_144672.3:c.267+1480C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.794,\N,\N,OTOA
386906,16:21694646:A>G,NM_144672.3:c.267+1500A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,2.897,\N,\N,OTOA
386907,16:21694650:C>T,NM_144672.3:c.267+1504C>T,\N,\N,5/27,Benign,\N,intron_variant,2.058,0.0643,1KG_AFR_AF,OTOA
386908,16:21694673:A>G,NM_144672.3:c.267+1527A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,0.322,0.0015,1KG_AFR_AF,OTOA
386909,16:21694688:C>A,NM_144672.3:c.267+1542C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,5.822,0.0014,1KG_AMR_AF,OTOA
386910,16:21694712:G>A,NM_144672.3:c.267+1566G>A,\N,\N,5/27,Benign,\N,intron_variant,9.561,0.0053,1KG_AFR_AF,OTOA
386911,16:21694729:T>C,NM_144672.3:c.267+1583T>C,\N,\N,5/27,Benign,\N,intron_variant,6.2,0.0386,1KG_AFR_AF,OTOA
386912,16:21694776:G>C,NM_144672.3:c.267+1630G>C,\N,\N,5/27,Unknown significance,\N,intron_variant,0.351,\N,\N,OTOA
386913,16:21694792:T>A,NM_144672.3:c.267+1646T>A,\N,\N,5/27,Unknown significance,\N,intron_variant,4.558,\N,\N,OTOA
386914,16:21694808:G>A,NM_144672.3:c.267+1662G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,2.133,0.001,1KG_EUR_AF,OTOA
386915,16:21694809:T>G,NM_144672.3:c.267+1663T>G,\N,\N,5/27,Unknown significance,\N,intron_variant,3.285,0.001,1KG_SAS_AF,OTOA
386916,16:21694815:A>G,NM_144672.3:c.267+1669A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,1.855,\N,\N,OTOA
386917,16:21694820:C>A,NM_144672.3:c.267+1674C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,3.548,0.001,1KG_SAS_AF,OTOA
386918,16:21694821:C>A,NM_144672.3:c.267+1675C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,2.746,0.0008,1KG_AFR_AF,OTOA
386919,16:21694834:C>G,NM_144672.3:c.267+1688C>G,\N,\N,5/27,Unknown significance,\N,intron_variant,0.102,\N,\N,OTOA
386920,16:21694839:C>A,NM_144672.3:c.267+1693C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,3.542,\N,\N,OTOA
386921,16:21694839:C>G,NM_144672.3:c.267+1693C>G,\N,\N,5/27,Unknown significance,\N,intron_variant,1.783,0.001,1KG_EAS_AF,OTOA
386922,16:21694840:C>T,NM_144672.3:c.267+1694C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.713,\N,\N,OTOA
386923,16:21694964:T>C,NM_144672.3:c.268-1587T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,3.691,\N,\N,OTOA
386924,16:21694967:C>T,NM_144672.3:c.268-1584C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,3.361,\N,\N,OTOA
386925,16:21694968:G>A,NM_144672.3:c.268-1583G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,3.79,\N,\N,OTOA
386926,16:21694978:G>T,NM_144672.3:c.268-1573G>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.078,\N,\N,OTOA
386927,16:21694979:A>C,NM_144672.3:c.268-1572A>C,\N,\N,5/27,Unknown significance,\N,intron_variant,2.684,\N,\N,OTOA
386928,16:21694986:C>T,NM_144672.3:c.268-1565C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,3.379,\N,\N,OTOA
386929,16:21694993:T>C,NM_144672.3:c.268-1558T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,0.198,\N,\N,OTOA
386930,16:21694995:T>C,NM_144672.3:c.268-1556T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,0.065,\N,\N,OTOA
386931,16:21695021:C>T,NM_144672.3:c.268-1530C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,0.363,\N,\N,OTOA
386932,16:21695092:GA>G,NM_144672.3:c.268-1458del,\N,\N,5/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
386933,16:21695092:GAT>G,NM_144672.3:c.268-1458_268-1457del,\N,\N,5/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
386934,16:21695093:AT>A,NM_144672.3:c.268-1444del,\N,\N,5/27,Benign,\N,intron_variant,1.841,0.9334,1KG_AFR_AF,OTOA
386935,16:21695122:C>T,NM_144672.3:c.268-1429C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,1.865,0.002,1KG_EAS_AF|1KG_SAS_AF,OTOA
386936,16:21695224:G>A,NM_144672.3:c.268-1327G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,5.734,0.0023,1KG_AFR_AF,OTOA
386937,16:21695232:G>C,NM_144672.3:c.268-1319G>C,\N,\N,5/27,Unknown significance,\N,intron_variant,1.285,0.0008,1KG_AFR_AF,OTOA
386938,16:21695302:C>G,NM_144672.3:c.268-1249C>G,\N,\N,5/27,Benign,\N,intron_variant,8.381,0.0061,1KG_AFR_AF,OTOA
386939,16:21695330:C>T,NM_144672.3:c.268-1221C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,9.059,0.001,1KG_EUR_AF,OTOA
386940,16:21695340:G>T,NM_144672.3:c.268-1211G>T,\N,\N,5/27,Unknown significance,\N,intron_variant,6.634,0.0014,1KG_AMR_AF,OTOA
386941,16:21695448:T>TA,NM_144672.3:c.268-1090dup,\N,\N,5/27,Unknown significance,\N,intron_variant,0.186,\N,\N,OTOA
386942,16:21695448:TAA>T,NM_144672.3:c.268-1091_268-1090del,\N,\N,5/27,Unknown significance,\N,intron_variant,5.828,\N,\N,OTOA
386943,16:21695449:A>T,NM_144672.3:c.268-1102A>T,\N,\N,5/27,Benign,\N,intron_variant,0.062,0.0051,1KG_SAS_AF,OTOA
386944,16:21695477:G>A,NM_144672.3:c.268-1074G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,3.774,0.001,1KG_SAS_AF,OTOA
386945,16:21695511:C>T,NM_144672.3:c.268-1040C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,5.528,0.001,1KG_EAS_AF,OTOA
386946,16:21695581:T>C,NM_144672.3:c.268-970T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,2.038,\N,\N,OTOA
386947,16:21695615:A>G,NM_144672.3:c.268-936A>G,\N,\N,5/27,Benign,\N,intron_variant,1.702,0.0143,1KG_SAS_AF,OTOA
386948,16:21695658:A>G,NM_144672.3:c.268-893A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,5.002,0.0008,1KG_AFR_AF,OTOA
386949,16:21695664:C>A,NM_144672.3:c.268-887C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,7.301,\N,\N,OTOA
386950,16:21695676:G>A,NM_144672.3:c.268-875G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,7.283,0.0008,1KG_AFR_AF,OTOA
386951,16:21695707:T>A,NM_144672.3:c.268-844T>A,\N,\N,5/27,Unknown significance,\N,intron_variant,7.325,0.0008,1KG_AFR_AF,OTOA
386952,16:21695728:G>T,NM_144672.3:c.268-823G>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.113,0.001,1KG_SAS_AF,OTOA
386953,16:21695740:G>C,NM_144672.3:c.268-811G>C,\N,\N,5/27,Unknown significance,\N,intron_variant,1.738,0.0008,1KG_AFR_AF,OTOA
386954,16:21695741:T>G,NM_144672.3:c.268-810T>G,\N,\N,5/27,Unknown significance,\N,intron_variant,4.677,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
386955,16:21695752:C>A,NM_144672.3:c.268-799C>A,\N,\N,5/27,Benign,\N,intron_variant,2.374,0.0389,1KG_SAS_AF,OTOA
386956,16:21695760:T>G,NM_144672.3:c.268-791T>G,\N,\N,5/27,Benign,\N,intron_variant,4.452,0.0386,1KG_AFR_AF,OTOA
386957,16:21695781:T>C,NM_144672.3:c.268-770T>C,\N,\N,5/27,Benign,\N,intron_variant,1.669,0.0098,1KG_AFR_AF,OTOA
386958,16:21695802:T>C,NM_144672.3:c.268-749T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,10.14,0.000115048,EXAC_NFE_AF,OTOA
386959,16:21695869:A>T,NM_001161683.1:c.26A>T,NP_001155155.1:p.Asp9Val,1/24,\N,Likely benign,\N,missense_variant,1.963,0.000314268,EVS_EA_AF,OTOA
386960,16:21695871:C>A,NM_001161683.1:c.28C>A,NP_001155155.1:p.Gln10Lys,1/24,\N,Likely benign,\N,missense_variant&splice_region_variant,6.407,0.000117316,EXAC_NFE_AF,OTOA
386961,16:21695871:C>T,NM_001161683.1:c.28C>T,NP_001155155.1:p.Gln10Ter,1/24,\N,Unknown significance,\N,stop_gained&splice_region_variant,4.978,0.000117316,EXAC_NFE_AF,OTOA
386962,16:21695897:G>A,NM_144672.3:c.268-654G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,2.401,0.00245098,EXAC_AMR_AF,OTOA
386963,16:21695925:A>G,NM_144672.3:c.268-626A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,7.149,0.00144509,EVS_AA_AF,OTOA
386964,16:21695968:G>A,NM_144672.3:c.268-583G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,5.202,0.001,1KG_EAS_AF,OTOA
386965,16:21695978:C>T,NM_144672.3:c.268-573C>T,\N,\N,5/27,Benign,\N,intron_variant,6.279,0.0242,1KG_AFR_AF,OTOA
386966,16:21696040:CCTT>C,NM_144672.3:c.268-510_268-508del,\N,\N,5/27,Benign,\N,intron_variant,4.512,0.0749,1KG_AMR_AF,OTOA
386967,16:21696040:CCTTATT>C,NM_144672.3:c.268-510_268-505del,\N,\N,5/27,Unknown significance,\N,intron_variant,7.421,\N,\N,OTOA
386968,16:21696040:CCTTATTATT>C,NM_144672.3:c.268-510_268-502del,\N,\N,5/27,Unknown significance,\N,intron_variant,7.466,\N,\N,OTOA
386969,16:21696041:C>A,NM_144672.3:c.268-510C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.028,0.0031,1KG_SAS_AF,OTOA
386970,16:21696041:CTTA>C,NM_144672.3:c.268-465_268-463del,\N,\N,5/27,Unknown significance,\N,intron_variant,7.252,\N,\N,OTOA
386971,16:21696041:CTTATTATTATTATTA>C,NM_144672.3:c.268-477_268-463del,\N,\N,5/27,Unknown significance,\N,intron_variant,6.892,\N,\N,OTOA
386972,16:21696050:A>G,NM_144672.3:c.268-501A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,2.987,0.0015,1KG_AFR_AF,OTOA
386973,16:21696059:A>ATT,NM_144672.3:c.268-491_268-490dup,\N,\N,5/27,Unknown significance,\N,intron_variant,0.161,\N,\N,OTOA
386974,16:21696074:ATTATTATTATTATTT>A,NM_144672.3:c.268-474_268-460del,\N,\N,5/27,Unknown significance,\N,intron_variant,1.521,\N,\N,OTOA
386975,16:21696077:ATTATTATTATTT>A,NM_144672.3:c.268-471_268-460del,\N,\N,5/27,Unknown significance,\N,intron_variant,1.565,\N,\N,OTOA
386976,16:21696080:ATTATTATTT>A,NM_144672.3:c.268-468_268-460del,\N,\N,5/27,Benign,\N,intron_variant,1.879,0.9185,1KG_EUR_AF,OTOA
386977,16:21696083:A>ATTATTT,NM_144672.3:c.268-465_268-460dup,\N,\N,5/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
386978,16:21696083:ATTATTT>A,NM_144672.3:c.268-465_268-460del,\N,\N,5/27,Unknown significance,\N,intron_variant,2.286,\N,\N,OTOA
386979,16:21696086:ATTT>A,NM_144672.3:c.268-461_268-459del,\N,\N,5/27,Unknown significance,\N,intron_variant,1.075,\N,\N,OTOA
386980,16:21696089:T>A,NM_144672.3:c.268-462T>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.945,\N,\N,OTOA
386981,16:21696105:G>A,NM_144672.3:c.268-446G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.027,0.0031,1KG_SAS_AF,OTOA
386982,16:21696129:GT>G,NM_144672.3:c.268-421del,\N,\N,5/27,Unknown significance,\N,intron_variant,6.358,\N,\N,OTOA
386983,16:21696133:C>T,NM_144672.3:c.268-418C>T,\N,\N,5/27,Benign,\N,intron_variant,7.013,0.0061,1KG_AFR_AF,OTOA
386984,16:21696141:C>T,NM_144672.3:c.268-410C>T,\N,\N,5/27,Benign,\N,intron_variant,7.011,0.0129,1KG_AFR_AF,OTOA
386985,16:21696163:C>T,NM_144672.3:c.268-388C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,7.533,0.002,1KG_EUR_AF,OTOA
386986,16:21696218:G>T,NM_144672.3:c.268-333G>T,\N,\N,5/27,Unknown significance,\N,intron_variant,0.327,0.001,1KG_EUR_AF,OTOA
386987,16:21696221:C>T,NM_144672.3:c.268-330C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,0.282,0.001,1KG_EAS_AF,OTOA
386988,16:21696262:G>C,NM_144672.3:c.268-289G>C,\N,\N,5/27,Unknown significance,\N,intron_variant,0.425,\N,\N,OTOA
386989,16:21696279:G>A,NM_144672.3:c.268-272G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.62,\N,\N,OTOA
386990,16:21696289:T>C,NM_144672.3:c.268-262T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,0.074,\N,\N,OTOA
386991,16:21696290:C>T,NM_144672.3:c.268-261C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,1.669,\N,\N,OTOA
386992,16:21696292:T>A,NM_144672.3:c.268-259T>A,\N,\N,5/27,Unknown significance,\N,intron_variant,1.39,\N,\N,OTOA
386993,16:21696306:C>T,NM_144672.3:c.268-245C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.82,0.001,1KG_EAS_AF,OTOA
386994,16:21696316:C>G,NM_144672.3:c.268-235C>G,\N,\N,5/27,Unknown significance,\N,intron_variant,1.455,0.0015,1KG_AFR_AF,OTOA
386995,16:21696323:G>A,NM_144672.3:c.268-228G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,3.289,0.001,1KG_EAS_AF,OTOA
386996,16:21696363:G>T,NM_144672.3:c.268-188G>T,\N,\N,5/27,Unknown significance,\N,intron_variant,0.296,0.0014,1KG_AMR_AF,OTOA
386997,16:21696396:A>G,NM_144672.3:c.268-155A>G,\N,\N,5/27,Unknown significance,\N,intron_variant,6.192,0.0015,1KG_AFR_AF,OTOA
386998,16:21696405:T>C,NM_144672.3:c.268-146T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,2.212,\N,\N,OTOA
386999,16:21696406:T>C,NM_144672.3:c.268-145T>C,\N,\N,5/27,Unknown significance,\N,intron_variant,2.118,0.001,1KG_EAS_AF,OTOA
387000,16:21696422:C>A,NM_144672.3:c.268-129C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,5.679,0.0029,1KG_AMR_AF,OTOA
387001,16:21696447:C>A,NM_144672.3:c.268-104C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,7.541,0.0008,1KG_AFR_AF,OTOA
387002,16:21696458:A>AT,NM_144672.3:c.268-92dup,\N,\N,5/27,Unknown significance,\N,intron_variant,1.658,\N,\N,OTOA
387003,16:21696464:G>T,NM_144672.3:c.268-87G>T,\N,\N,5/27,Unknown significance,\N,intron_variant,2.355,0.001,1KG_SAS_AF,OTOA
387004,16:21696469:G>C,NM_144672.3:c.268-82G>C,\N,\N,5/27,Benign,\N,intron_variant,0.172,0.0836,1KG_AMR_AF,OTOA
387005,16:21696485:C>G,NM_144672.3:c.268-66C>G,\N,\N,5/27,Unknown significance,\N,intron_variant,12.28,0.002,1KG_SAS_AF,OTOA
387006,16:21696516:T>G,NM_144672.3:c.268-35T>G,\N,\N,5/27,Unknown significance,\N,intron_variant,10.41,0.00052749,EXAC_NFE_AF,OTOA
387007,16:21696523:AC>A,NM_144672.3:c.268-26del,\N,\N,5/27,Unknown significance,\N,intron_variant,5.188,0.0000150652,EXAC_NFE_AF,OTOA
387008,16:21696524:C>G,NM_144672.3:c.268-27C>G,\N,\N,5/27,Unknown significance,\N,intron_variant,6.768,0.0038,1KG_AFR_AF,OTOA
387009,16:21696525:C>A,NM_144672.3:c.268-26C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,6.357,0.0000606134,EXAC_SAS_AF,OTOA
387010,16:21696525:C>T,NM_144672.3:c.268-26C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,4.882,0.0000150666,EXAC_NFE_AF,OTOA
387011,16:21696526:G>A,NM_144672.3:c.268-25G>A,\N,\N,5/27,Unknown significance,\N,intron_variant,5.598,0.0000150639,EXAC_NFE_AF,OTOA
387012,16:21696529:T>A,NM_144672.3:c.268-22T>A,\N,\N,5/27,Unknown significance,\N,intron_variant,9.242,0.004,1KG_EAS_AF,OTOA
387013,16:21696533:C>G,NM_144672.3:c.268-18C>G,\N,\N,5/27,Unknown significance,\N,intron_variant,8.972,0.0000150584,EXAC_NFE_AF,OTOA
387014,16:21696537:C>A,NM_144672.3:c.268-14C>A,\N,\N,5/27,Unknown significance,\N,intron_variant,11.05,0.000116279,EVS_EA_AF,OTOA
387015,16:21696538:A>C,NM_144672.3:c.268-13A>C,\N,\N,5/27,Unknown significance,\N,intron_variant,4.973,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
387016,16:21696539:C>T,NM_144672.3:c.268-12C>T,\N,\N,5/27,Unknown significance,\N,intron_variant,10.45,0.000116279,EVS_EA_AF,OTOA
387017,16:21696542:C>G,NM_144672.3:c.268-9C>G,\N,\N,5/27,Unknown significance,\N,intron_variant,5.741,0.0000150457,EXAC_NFE_AF,OTOA
387018,16:21696545:A>C,NM_144672.3:c.268-6A>C,\N,\N,5/27,Unknown significance,\N,splice_region_variant&intron_variant,0.032,0.0000150448,EXAC_NFE_AF,OTOA
387019,16:21696549:A>G,NM_144672.3:c.268-2A>G,\N,\N,5/27,Unknown significance,\N,splice_acceptor_variant,20.8,0.0000150448,EXAC_NFE_AF,OTOA
387020,16:21696556:C>T,NM_144672.3:c.273C>T,NP_653273.3:p.Ala91=,6/28,\N,Unknown significance,\N,synonymous_variant,13.42,0.0000967867,EXAC_AFR_AF,OTOA
387021,16:21696557:G>T,NM_144672.3:c.274G>T,NP_653273.3:p.Val92Leu,6/28,\N,Likely benign,\N,missense_variant,9.503,0.000181774,EXAC_SAS_AF,OTOA
387022,16:21696560:G>C,NM_144672.3:c.277G>C,NP_653273.3:p.Glu93Gln,6/28,\N,Likely benign,\N,missense_variant,9.391,0.00110865,EXAC_OTH_AF,OTOA
387023,16:21696564:A>C,NM_144672.3:c.281A>C,NP_653273.3:p.Asn94Thr,6/28,\N,Likely benign,\N,missense_variant,0.306,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
387024,16:21696566:C>T,NM_144672.3:c.283C>T,NP_653273.3:p.His95Tyr,6/28,\N,Likely benign,\N,missense_variant,3.396,0.0000150358,EXAC_NFE_AF,OTOA
387025,16:21696567:A>C,NM_144672.3:c.284A>C,NP_653273.3:p.His95Pro,6/28,\N,Benign,\N,missense_variant,23.6,0.015,OTO_TR_AF,OTOA
387026,16:21696568:CCTGGAGCAGCGT>C,NM_144672.3:c.289_300del,NP_653273.3:p.Glu97_Leu100del,6/28,\N,Unknown significance,\N,inframe_deletion,16.99,\N,\N,OTOA
387027,16:21696569:C>CTCCATTT,NM_144672.3:c.287_288insCCATTTT,NP_653273.3:p.Glu97HisfsTer116,6/28,\N,Unknown significance,\N,frameshift_variant,33,\N,\N,OTOA
387028,16:21696571:G>GCAGATAAGAAAACT,NM_144672.3:c.288_289insCAGATAAGAAAACT,NP_653273.3:p.Glu97GlnfsTer19,6/28,\N,Unknown significance,\N,frameshift_variant,24,\N,\N,OTOA
387029,16:21696574:G>GGCC,NM_144672.3:c.291_292insGCC,NP_653273.3:p.Glu97_Gln98insAla,6/28,\N,Unknown significance,\N,inframe_insertion,7.879,\N,\N,OTOA
387030,16:21696585:A>C,NM_144672.3:c.302A>C,NP_653273.3:p.His101Pro,6/28,\N,Benign,\N,missense_variant,18.94,0.00625,OTO_US_AF,OTOA
387031,16:21696587:C>T,NM_144672.3:c.304C>T,NP_653273.3:p.Gln102Ter,6/28,\N,Unknown significance,\N,stop_gained,35,0.000116279,EVS_EA_AF,OTOA
387032,16:21696588:AG>A,NM_144672.3:c.306del,NP_653273.3:p.Gln102HisfsTer9,6/28,\N,Unknown significance,\N,frameshift_variant,28.1,0.000115955,EXAC_EAS_AF,OTOA
387033,16:21696593:C>G,NM_144672.3:c.310C>G,NP_653273.3:p.Gln104Glu,6/28,\N,Unknown significance,\N,missense_variant,22.3,0.0000150195,EXAC_NFE_AF,OTOA
387034,16:21696601:G>T,NM_144672.3:c.318G>T,NP_653273.3:p.Leu106=,6/28,\N,Unknown significance,\N,synonymous_variant,8.103,0.0000150182,EXAC_NFE_AF,OTOA
387035,16:21696604:GGAGGACCTGAGGAAGACA>G,NM_144672.3:c.324_341del,NP_653273.3:p.Glu108_Thr113del,6/28,\N,Unknown significance,\N,inframe_deletion,22.2,\N,\N,OTOA
387036,16:21696614:A>G,NM_144672.3:c.331A>G,NP_653273.3:p.Arg111Gly,6/28,\N,Unknown significance,\N,missense_variant,25.8,0.0000150218,EXAC_NFE_AF,OTOA
387037,16:21696618:A>G,NM_144672.3:c.335A>G,NP_653273.3:p.Lys112Arg,6/28,\N,Likely benign,\N,missense_variant,0.94,0.0000300472,EXAC_NFE_AF,OTOA
387038,16:21696622:A>G,NM_144672.3:c.339A>G,NP_653273.3:p.Thr113=,6/28,\N,Unknown significance,\N,synonymous_variant,0.355,0.000151515,EXAC_FIN_AF,OTOA
387039,16:21696625:C>G,NM_144672.3:c.342C>G,NP_653273.3:p.Asp114Glu,6/28,\N,Likely benign,\N,missense_variant,22.4,0.000121153,EXAC_SAS_AF,OTOA
387040,16:21696626:G>A,NM_144672.3:c.343G>A,NP_653273.3:p.Ala115Thr,6/28,\N,Likely benign,\N,missense_variant,7.714,0.000116117,EXAC_EAS_AF,OTOA
387041,16:21696630:A>G,NM_144672.3:c.347A>G,NP_653273.3:p.Gln116Arg,6/28,\N,Unknown significance,\N,missense_variant,19.88,0.0000450667,EXAC_NFE_AF,OTOA
387042,16:21696631:G>A,NM_144672.3:c.348G>A,NP_653273.3:p.Gln116=,6/28,\N,Unknown significance,\N,synonymous_variant,4.991,0.0000963206,EXAC_AFR_AF,OTOA
387043,16:21696634:G>A,NM_144672.3:c.351G>A,NP_653273.3:p.Gln117=,6/28,\N,Unknown significance,\N,synonymous_variant,2.053,0.000151745,EXAC_FIN_AF,OTOA
387044,16:21696638:C>T,NM_144672.3:c.355C>T,NP_653273.3:p.Arg119Cys,6/28,\N,Unknown significance,\N,missense_variant,25.5,0.0000963948,EXAC_AFR_AF,OTOA
387045,16:21696641:A>T,NM_144672.3:c.358A>T,NP_653273.3:p.Thr120Ser,6/28,\N,Unknown significance,\N,missense_variant,19.96,0.000060584,EXAC_SAS_AF,OTOA
387046,16:21696658:C>T,NM_144672.3:c.375C>T,NP_653273.3:p.Leu125=,6/28,\N,Unknown significance,\N,synonymous_variant,13.67,\N,\N,OTOA
387047,16:21696660:T>C,NM_144672.3:c.377T>C,NP_653273.3:p.Leu126Ser,6/28,\N,Unknown significance,\N,missense_variant,21.1,\N,\N,OTOA
387048,16:21696662:G>A,NM_144672.3:c.379G>A,NP_653273.3:p.Glu127Lys,6/28,\N,Unknown significance,\N,missense_variant,23.3,0.0000866401,EXAC_AMR_AF,OTOA
387049,16:21696667:CAAG>C,NM_144672.3:c.388_390del,NP_653273.3:p.Lys130del,6/28,\N,Unknown significance,\N,inframe_deletion,21.4,0.0000150471,EXAC_NFE_AF,OTOA
387050,16:21696676:C>A,NM_144672.3:c.393C>A,NP_653273.3:p.Asp131Glu,6/28,\N,Likely benign,\N,missense_variant,11.73,0.0000967867,EXAC_AFR_AF,OTOA
387051,16:21696676:C>T,NM_144672.3:c.393C>T,NP_653273.3:p.Asp131=,6/28,\N,Unknown significance,\N,synonymous_variant,14.69,0.000150625,EXAC_NFE_AF,OTOA
387052,16:21696679:C>T,NM_144672.3:c.396C>T,NP_653273.3:p.Gly132=,6/28,\N,Unknown significance,\N,synonymous_variant,12.24,0.003125,OTO_CO_AF,OTOA
387053,16:21696684:T>C,NM_144672.3:c.399+2T>C,\N,\N,6/27,Unknown significance,\N,splice_donor_variant,24.1,0.000150748,EXAC_NFE_AF,OTOA
387054,16:21696684:T>G,NM_144672.3:c.399+2T>G,\N,\N,6/27,Unknown significance,\N,splice_donor_variant,24.5,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
387055,16:21696698:C>A,NM_144672.3:c.399+16C>A,\N,\N,6/27,Unknown significance,\N,intron_variant,8.578,0.0000906728,EXAC_NFE_AF,OTOA
387056,16:21696704:G>A,NM_144672.3:c.399+22G>A,\N,\N,6/27,Benign,\N,intron_variant,5.906,0.01,OTO_TR_AF,OTOA
387057,16:21696704:G>C,NM_144672.3:c.399+22G>C,\N,\N,6/27,Unknown significance,\N,intron_variant,3.237,0.000963222,EXAC_AMR_AF,OTOA
387058,16:21696715:A>T,NM_144672.3:c.399+33A>T,\N,\N,6/27,Unknown significance,\N,intron_variant,4.115,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
387059,16:21696723:C>T,NM_144672.3:c.399+41C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,4.89,0.0000980008,EXAC_AFR_AF,OTOA
387060,16:21696735:T>G,NM_144672.3:c.399+53T>G,\N,\N,6/27,Unknown significance,\N,intron_variant,1.571,\N,\N,OTOA
387061,16:21696754:G>A,NM_144672.3:c.399+72G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,2.698,0.001,1KG_SAS_AF,OTOA
387062,16:21696758:C>A,NM_144672.3:c.399+76C>A,\N,\N,6/27,Benign,\N,intron_variant,7.3,0.0113,1KG_AFR_AF,OTOA
387063,16:21696767:G>T,NM_144672.3:c.399+85G>T,\N,\N,6/27,Unknown significance,\N,intron_variant,3.555,0.003,1KG_EUR_AF,OTOA
387064,16:21696789:T>G,NM_144672.3:c.399+107T>G,\N,\N,6/27,Unknown significance,\N,intron_variant,2.367,0.0008,1KG_AFR_AF,OTOA
387065,16:21696790:T>C,NM_144672.3:c.399+108T>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.623,0.0015,1KG_AFR_AF,OTOA
387066,16:21696793:T>C,NM_144672.3:c.399+111T>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.645,\N,\N,OTOA
387067,16:21696794:C>A,NM_144672.3:c.399+112C>A,\N,\N,6/27,Unknown significance,\N,intron_variant,5.477,\N,\N,OTOA
387068,16:21696795:T>C,NM_144672.3:c.399+113T>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.271,\N,\N,OTOA
387069,16:21696806:C>T,NM_144672.3:c.399+124C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,3.391,\N,\N,OTOA
387070,16:21696923:A>T,NM_144672.3:c.399+241A>T,\N,\N,6/27,Benign,\N,intron_variant,0.359,0.006,1KG_EUR_AF,OTOA
387071,16:21696955:C>T,NM_144672.3:c.399+273C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,2.351,\N,\N,OTOA
387072,16:21696985:G>A,NM_144672.3:c.399+303G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,1.798,\N,\N,OTOA
387073,16:21697032:C>A,NM_144672.3:c.399+350C>A,\N,\N,6/27,Unknown significance,\N,intron_variant,0.114,\N,\N,OTOA
387074,16:21697033:A>C,NM_144672.3:c.399+351A>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.007,\N,\N,OTOA
387075,16:21697036:A>C,NM_144672.3:c.399+354A>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.43,\N,\N,OTOA
387076,16:21697040:T>A,NM_144672.3:c.399+358T>A,\N,\N,6/27,Unknown significance,\N,intron_variant,0.244,\N,\N,OTOA
387077,16:21697046:G>A,NM_144672.3:c.399+364G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,1.5,\N,\N,OTOA
387078,16:21697072:C>T,NM_144672.3:c.399+390C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,0.014,\N,\N,OTOA
387079,16:21697106:C>T,NM_144672.3:c.399+424C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,0.502,\N,\N,OTOA
387080,16:21697127:G>A,NM_144672.3:c.399+445G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,0.427,0.001,1KG_EUR_AF,OTOA
387081,16:21697168:C>G,NM_144672.3:c.399+486C>G,\N,\N,6/27,Unknown significance,\N,intron_variant,1.901,0.001,1KG_SAS_AF,OTOA
387082,16:21697203:A>G,NM_144672.3:c.399+521A>G,\N,\N,6/27,Unknown significance,\N,intron_variant,1.009,0.001,1KG_EAS_AF,OTOA
387083,16:21697207:C>T,NM_144672.3:c.399+525C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,1.296,\N,\N,OTOA
387084,16:21697216:AT>A,NM_144672.3:c.399+536del,\N,\N,6/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387085,16:21697231:A>G,NM_144672.3:c.399+549A>G,\N,\N,6/27,Unknown significance,\N,intron_variant,2.922,0.0041,1KG_SAS_AF,OTOA
387086,16:21697234:T>G,NM_144672.3:c.399+552T>G,\N,\N,6/27,Unknown significance,\N,intron_variant,4.095,0.0008,1KG_AFR_AF,OTOA
387087,16:21697261:CA>C,NM_144672.3:c.399+580del,\N,\N,6/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387088,16:21697316:A>C,NM_144672.3:c.399+634A>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.619,0.0008,1KG_AFR_AF,OTOA
387089,16:21697323:G>A,NM_144672.3:c.399+641G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,0.372,\N,\N,OTOA
387090,16:21697401:AG>A,NM_144672.3:c.399+721del,\N,\N,6/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387091,16:21697416:T>TA,NM_144672.3:c.399+739dup,\N,\N,6/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387092,16:21697424:G>A,NM_144672.3:c.399+742G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,3.187,\N,\N,OTOA
387093,16:21697427:A>G,NM_144672.3:c.399+745A>G,\N,\N,6/27,Unknown significance,\N,intron_variant,1.22,\N,\N,OTOA
387094,16:21697539:A>T,NM_144672.3:c.399+857A>T,\N,\N,6/27,Unknown significance,\N,intron_variant,1.27,0.001,1KG_EAS_AF,OTOA
387095,16:21697565:G>C,NM_144672.3:c.399+883G>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.125,\N,\N,OTOA
387096,16:21697610:C>CT,NM_144672.3:c.399+941dup,\N,\N,6/27,Unknown significance,\N,intron_variant,1.252,\N,\N,OTOA
387097,16:21697610:C>T,NM_144672.3:c.399+928C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,0.294,\N,\N,OTOA
387098,16:21697610:CT>C,NM_144672.3:c.399+941del,\N,\N,6/27,Unknown significance,\N,intron_variant,0.975,\N,\N,OTOA
387099,16:21697612:T>C,NM_144672.3:c.399+930T>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.685,\N,\N,OTOA
387100,16:21697613:T>C,NM_144672.3:c.399+931T>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.194,\N,\N,OTOA
387101,16:21697623:T>C,NM_144672.3:c.399+941T>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.092,\N,\N,OTOA
387102,16:21697627:A>G,NM_144672.3:c.399+945A>G,\N,\N,6/27,Unknown significance,\N,intron_variant,0.693,\N,\N,OTOA
387103,16:21697631:A>G,NM_144672.3:c.399+949A>G,\N,\N,6/27,Unknown significance,\N,intron_variant,1.602,0.0008,1KG_AFR_AF,OTOA
387104,16:21697756:C>T,NM_144672.3:c.400-978C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,0.144,0.0015,1KG_AFR_AF,OTOA
387105,16:21697757:G>A,NM_144672.3:c.400-977G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,1.34,0.001,1KG_EAS_AF,OTOA
387106,16:21697781:A>T,NM_144672.3:c.400-953A>T,\N,\N,6/27,Benign,\N,intron_variant,0.563,0.0159,1KG_AFR_AF,OTOA
387107,16:21697789:T>C,NM_144672.3:c.400-945T>C,\N,\N,6/27,Benign,\N,intron_variant,1.609,0.0501,1KG_SAS_AF,OTOA
387108,16:21697803:G>A,NM_144672.3:c.400-931G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,1.596,0.001,1KG_EAS_AF,OTOA
387109,16:21697939:A>G,NM_144672.3:c.400-795A>G,\N,\N,6/27,Unknown significance,\N,intron_variant,1.353,0.001,1KG_SAS_AF,OTOA
387110,16:21697968:G>A,NM_144672.3:c.400-766G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,2.649,\N,\N,OTOA
387111,16:21697973:C>T,NM_144672.3:c.400-761C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,2.185,0.0014,1KG_AMR_AF,OTOA
387112,16:21698026:C>T,NM_144672.3:c.400-708C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,3.088,\N,\N,OTOA
387113,16:21698053:T>C,NM_144672.3:c.400-681T>C,\N,\N,6/27,Unknown significance,\N,intron_variant,2.726,\N,\N,OTOA
387114,16:21698059:C>T,NM_144672.3:c.400-675C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,4.336,\N,\N,OTOA
387115,16:21698119:TG>T,NM_144672.3:c.400-612del,\N,\N,6/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387116,16:21698163:A>G,NM_144672.3:c.400-571A>G,\N,\N,6/27,Unknown significance,\N,intron_variant,6.808,0.002,1KG_EAS_AF,OTOA
387117,16:21698184:G>A,NM_144672.3:c.400-550G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,0.252,\N,\N,OTOA
387118,16:21698200:C>T,NM_144672.3:c.400-534C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,0.476,0.001,1KG_EUR_AF,OTOA
387119,16:21698214:A>C,NM_144672.3:c.400-520A>C,\N,\N,6/27,Unknown significance,\N,intron_variant,1.06,0.001,1KG_SAS_AF,OTOA
387120,16:21698281:C>T,NM_144672.3:c.400-453C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,0.24,\N,\N,OTOA
387121,16:21698282:G>A,NM_144672.3:c.400-452G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,0.921,\N,\N,OTOA
387122,16:21698298:C>T,NM_144672.3:c.400-436C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,1.369,\N,\N,OTOA
387123,16:21698299:G>A,NM_144672.3:c.400-435G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,1.368,\N,\N,OTOA
387124,16:21698336:A>G,NM_144672.3:c.400-398A>G,\N,\N,6/27,Unknown significance,\N,intron_variant,0.441,\N,\N,OTOA
387125,16:21698400:G>C,NM_144672.3:c.400-334G>C,\N,\N,6/27,Unknown significance,\N,intron_variant,1.334,0.0008,1KG_AFR_AF,OTOA
387126,16:21698407:C>T,NM_144672.3:c.400-327C>T,\N,\N,6/27,Benign,\N,intron_variant,3.337,0.0635,1KG_AFR_AF,OTOA
387127,16:21698412:G>A,NM_144672.3:c.400-322G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,1.898,\N,\N,OTOA
387128,16:21698465:G>GGT,NM_144672.3:c.400-268_400-267insTG,\N,\N,6/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387129,16:21698468:A>ATTCT,NM_144672.3:c.400-266_400-265insTTCT,\N,\N,6/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387130,16:21698471:A>C,NM_144672.3:c.400-263A>C,\N,\N,6/27,Unknown significance,\N,intron_variant,0.514,\N,\N,OTOA
387131,16:21698502:T>C,NM_144672.3:c.400-232T>C,\N,\N,6/27,Unknown significance,\N,intron_variant,2.835,0.001,1KG_EUR_AF,OTOA
387132,16:21698536:G>A,NM_144672.3:c.400-198G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,6.462,\N,\N,OTOA
387133,16:21698538:C>A,NM_144672.3:c.400-196C>A,\N,\N,6/27,Unknown significance,\N,intron_variant,3.286,0.001,1KG_SAS_AF,OTOA
387134,16:21698557:G>T,NM_144672.3:c.400-177G>T,\N,\N,6/27,Unknown significance,\N,intron_variant,3.758,0.0014,1KG_AMR_AF,OTOA
387135,16:21698558:G>T,NM_144672.3:c.400-176G>T,\N,\N,6/27,Unknown significance,\N,intron_variant,0.242,0.001,1KG_SAS_AF,OTOA
387136,16:21698574:T>A,NM_144672.3:c.400-160T>A,\N,\N,6/27,Unknown significance,\N,intron_variant,6.272,\N,\N,OTOA
387137,16:21698588:T>C,NM_144672.3:c.400-146T>C,\N,\N,6/27,Unknown significance,\N,intron_variant,1.619,\N,\N,OTOA
387138,16:21698641:A>T,NM_144672.3:c.400-93A>T,\N,\N,6/27,Unknown significance,\N,intron_variant,2.334,0.001,1KG_SAS_AF,OTOA
387139,16:21698668:C>A,NM_144672.3:c.400-66C>A,\N,\N,6/27,Unknown significance,\N,intron_variant,7.989,0.002,1KG_EAS_AF,OTOA
387140,16:21698673:C>T,NM_144672.3:c.400-61C>T,\N,\N,6/27,Benign,\N,intron_variant,3.483,0.0333,1KG_AFR_AF,OTOA
387141,16:21698689:G>A,NM_144672.3:c.400-45G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,2.072,0.0000865801,EXAC_AMR_AF,OTOA
387142,16:21698693:G>A,NM_144672.3:c.400-41G>A,\N,\N,6/27,Unknown significance,\N,intron_variant,4.842,0.0000150435,EXAC_NFE_AF,OTOA
387143,16:21698699:T>A,NM_144672.3:c.400-35T>A,\N,\N,6/27,Unknown significance,\N,intron_variant,7.99,0.000116686,EXAC_EAS_AF,OTOA
387144,16:21698709:A>T,NM_144672.3:c.400-25A>T,\N,\N,6/27,Unknown significance,\N,intron_variant,3.089,0.0000150322,EXAC_NFE_AF,OTOA
387145,16:21698710:C>T,NM_144672.3:c.400-24C>T,\N,\N,6/27,Unknown significance,\N,intron_variant,3.509,0.00221239,EXAC_OTH_AF,OTOA
387146,16:21698724:A>G,NM_144672.3:c.400-10A>G,\N,\N,6/27,Unknown significance,\N,intron_variant,2.147,0.0000150182,EXAC_NFE_AF,OTOA
387147,16:21698735:A>G,NM_144672.3:c.401A>G,NP_653273.3:p.Asp134Gly,7/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,24.8,0.000951228,EXAC_AMR_AF,OTOA
387148,16:21698736:C>T,NM_144672.3:c.402C>T,NP_653273.3:p.Asp134=,7/28,\N,Unknown significance,\N,splice_region_variant&synonymous_variant,9.912,0.0000864753,EXAC_AMR_AF,OTOA
387149,16:21698744:ACAT>A,NM_144672.3:c.418_420del,NP_653273.3:p.Ile140del,7/28,\N,Unknown significance,\N,inframe_deletion,10.57,0.000481325,EXAC_AFR_AF,OTOA
387150,16:21698748:C>A,NM_144672.3:c.414C>A,NP_653273.3:p.Ile138=,7/28,\N,Unknown significance,\N,synonymous_variant,11.96,\N,\N,OTOA
387151,16:21698752:A>C,NM_144672.3:c.418A>C,NP_653273.3:p.Ile140Leu,7/28,\N,Likely benign,\N,missense_variant,1.131,0.00162225,EXAC_EAS_AF,OTOA
387152,16:21698755:G>A,NM_144672.3:c.421G>A,NP_653273.3:p.Asp141Asn,7/28,\N,Likely benign,\N,missense_variant,12.38,0.0014,1KG_AMR_AF,OTOA
387153,16:21698770:C>A,NM_144672.3:c.436C>A,NP_653273.3:p.Arg146=,7/28,\N,Unknown significance,\N,synonymous_variant,11.31,0.001,1KG_EUR_AF,OTOA
387154,16:21698770:C>T,NM_144672.3:c.436C>T,NP_653273.3:p.Arg146Ter,7/28,\N,Unknown significance,\N,stop_gained,35,0.0000149939,EXAC_NFE_AF,OTOA
387155,16:21698771:G>A,NM_144672.3:c.437G>A,NP_653273.3:p.Arg146Gln,7/28,\N,Likely benign,\N,missense_variant,13.54,0.0000864304,EXAC_AMR_AF,OTOA
387156,16:21698776:C>T,NM_144672.3:c.442C>T,NP_653273.3:p.Arg148Ter,7/28,\N,Unknown significance,\N,stop_gained,35,0.000115768,EXAC_EAS_AF,OTOA
387157,16:21698777:G>A,NM_144672.3:c.443G>A,NP_653273.3:p.Arg148Gln,7/28,\N,Likely benign,\N,missense_variant,5.795,0.0000864304,EXAC_AMR_AF,OTOA
387158,16:21698780:C>A,NM_144672.3:c.446C>A,NP_653273.3:p.Ala149Asp,7/28,\N,Unknown significance,\N,missense_variant,28.8,0.000192197,EXAC_AFR_AF,OTOA
387159,16:21698780:C>T,NM_144672.3:c.446C>T,NP_653273.3:p.Ala149Val,7/28,\N,Likely benign,\N,missense_variant,13.34,0.0000149903,EXAC_NFE_AF,OTOA
387160,16:21698785:C>G,NM_144672.3:c.451C>G,NP_653273.3:p.Gln151Glu,7/28,\N,Unknown significance,\N,missense_variant,25.1,0.000116279,EVS_EA_AF,OTOA
387161,16:21698789:G>A,NM_144672.3:c.455G>A,NP_653273.3:p.Ser152Asn,7/28,\N,Unknown significance,\N,missense_variant,19.2,0.000259246,EXAC_AMR_AF,OTOA
387162,16:21698796:C>T,NM_144672.3:c.462C>T,NP_653273.3:p.Gly154=,7/28,\N,Unknown significance,\N,synonymous_variant,17.17,0.00190114,EXAC_AMR_AF,OTOA
387163,16:21698797:G>A,NM_144672.3:c.463G>A,NP_653273.3:p.Val155Met,7/28,\N,Likely benign,\N,missense_variant,22.1,0.0000749423,EXAC_NFE_AF,OTOA
387164,16:21698803:C>T,NM_144672.3:c.469C>T,NP_653273.3:p.Arg157Cys,7/28,\N,Unknown significance,\N,missense_variant,34,0.0000299751,EXAC_NFE_AF,OTOA
387165,16:21698805:C>A,NM_144672.3:c.471C>A,NP_653273.3:p.Arg157=,7/28,\N,Unknown significance,\N,synonymous_variant,17.5,0.0000149871,EXAC_NFE_AF,OTOA
387166,16:21698812:T>C,NM_144672.3:c.478T>C,NP_653273.3:p.Phe160Leu,7/28,\N,Unknown significance,\N,missense_variant,17.68,0.0000960984,EXAC_AFR_AF,OTOA
387167,16:21698817:C>T,NM_144672.3:c.483C>T,NP_653273.3:p.Leu161=,7/28,\N,Unknown significance,\N,synonymous_variant,13.66,0.0000299733,EXAC_NFE_AF,OTOA
387168,16:21698827:G>A,NM_144672.3:c.493G>A,NP_653273.3:p.Glu165Lys,7/28,\N,Unknown significance,\N,missense_variant,25.7,0.000227376,EVS_AA_AF,OTOA
387169,16:21698829:G>A,NM_144672.3:c.495G>A,NP_653273.3:p.Glu165=,7/28,\N,Unknown significance,\N,synonymous_variant,11.68,0.000480584,EXAC_AFR_AF,OTOA
387170,16:21698832:G>T,NM_144672.3:c.498G>T,NP_653273.3:p.Arg166Ser,7/28,\N,Unknown significance,\N,missense_variant,26.6,0.0000149858,EXAC_NFE_AF,OTOA
387171,16:21698833:T>A,NM_144672.3:c.499T>A,NP_653273.3:p.Cys167Ser,7/28,\N,Unknown significance,\N,missense_variant,26.2,0.000755972,EXAC_FIN_AF,OTOA
387172,16:21698833:T>G,NM_144672.3:c.499T>G,NP_653273.3:p.Cys167Gly,7/28,\N,Unknown significance,\N,missense_variant,25.6,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
387173,16:21698858:A>G,NM_144672.3:c.524A>G,NP_653273.3:p.Glu175Gly,7/28,\N,Unknown significance,\N,missense_variant,29.2,0.0000149867,EXAC_NFE_AF,OTOA
387174,16:21698860:T>C,NM_144672.3:c.526T>C,NP_653273.3:p.Cys176Arg,7/28,\N,Unknown significance,\N,missense_variant,26.1,0.0000149867,EXAC_NFE_AF,OTOA
387175,16:21698865:G>A,NM_144672.3:c.531G>A,NP_653273.3:p.Val177=,7/28,\N,Unknown significance,\N,synonymous_variant,11.73,0.000121124,EXAC_SAS_AF,OTOA
387176,16:21698865:G>T,NM_144672.3:c.531G>T,NP_653273.3:p.Val177=,7/28,\N,Unknown significance,\N,synonymous_variant,10.59,0.000116279,EVS_EA_AF,OTOA
387177,16:21698866:G>A,NM_144672.3:c.532G>A,NP_653273.3:p.Glu178Lys,7/28,\N,Unknown significance,\N,missense_variant,20.9,0.000115607,EXAC_EAS_AF,OTOA
387178,16:21698868:G>A,NM_144672.3:c.534G>A,NP_653273.3:p.Glu178=,7/28,\N,Unknown significance,\N,synonymous_variant,11.79,0.000227376,EVS_AA_AF,OTOA
387179,16:21698895:C>CTCAGGGAG,NM_144672.3:c.562_569dup,NP_653273.3:p.Phe191GlnfsTer48,7/28,\N,Unknown significance,\N,frameshift_variant,25.9,0.000045018,EXAC_NFE_AF,OTOA
387180,16:21698895:C>T,NM_144672.3:c.561C>T,NP_653273.3:p.Ser187=,7/28,\N,Unknown significance,\N,synonymous_variant,10.09,0.000015006,EXAC_NFE_AF,OTOA
387181,16:21698907:T>C,NM_144672.3:c.573T>C,NP_653273.3:p.Phe191=,7/28,\N,Unknown significance,\N,synonymous_variant,0.124,0.00030292,EXAC_SAS_AF,OTOA
387182,16:21698909:T>G,NM_144672.3:c.575T>G,NP_653273.3:p.Leu192Arg,7/28,\N,Unknown significance,\N,missense_variant,24.5,0.0000963391,EXAC_AFR_AF,OTOA
387183,16:21698917:G>A,NM_144672.3:c.583G>A,NP_653273.3:p.Asp195Asn,7/28,\N,Likely benign,\N,missense_variant,10.38,0.001,1KG_EUR_AF,OTOA
387184,16:21698925:AGAGCGGCTCCCTCGG>A,NM_144672.3:c.594_608del,NP_653273.3:p.Glu198_Arg202del,7/28,\N,Unknown significance,\N,inframe_deletion,10.22,\N,\N,OTOA
387185,16:21698928:G>A,NM_144672.3:c.594G>A,NP_653273.3:p.Glu198=,7/28,\N,Unknown significance,\N,synonymous_variant,0.497,0.000116795,EXAC_EAS_AF,OTOA
387186,16:21698929:C>A,NM_144672.3:c.595C>A,NP_653273.3:p.Arg199=,7/28,\N,Unknown significance,\N,synonymous_variant,14.63,\N,\N,OTOA
387187,16:21698929:C>T,NM_144672.3:c.595C>T,NP_653273.3:p.Arg199Trp,7/28,\N,Likely benign,\N,missense_variant,13.35,0.000116279,EVS_EA_AF,OTOA
387188,16:21698930:G>A,NM_144672.3:c.596G>A,NP_653273.3:p.Arg199Gln,7/28,\N,Likely benign,\N,missense_variant,4.74,0.000153186,EXAC_FIN_AF,OTOA
387189,16:21698930:G>C,NM_144672.3:c.596G>C,NP_653273.3:p.Arg199Pro,7/28,\N,Likely benign,\N,missense_variant,9.009,0.000015124,EXAC_NFE_AF,OTOA
387190,16:21698938:C>T,NM_144672.3:c.604C>T,NP_653273.3:p.Arg202Trp,7/28,\N,Likely benign,\N,missense_variant,15.4,0.000117897,EXAC_EAS_AF,OTOA
387191,16:21698939:G>A,NM_144672.3:c.605G>A,NP_653273.3:p.Arg202Gln,7/28,\N,Likely benign,\N,missense_variant,0.137,0.00225225,EXAC_OTH_AF,OTOA
387192,16:21698939:G>C,NM_144672.3:c.605G>C,NP_653273.3:p.Arg202Pro,7/28,\N,Likely benign,\N,missense_variant,5.723,0.0014,1KG_AMR_AF,OTOA
387193,16:21698945:T>C,NM_144672.3:c.611T>C,NP_653273.3:p.Leu204Pro,7/28,\N,Unknown significance,\N,missense_variant,23.4,0.0000152411,EXAC_NFE_AF,OTOA
387194,16:21698947:C>A,NM_144672.3:c.613C>A,NP_653273.3:p.Arg205Ser,7/28,\N,Likely benign,\N,missense_variant,9.251,0.0000152551,EXAC_NFE_AF,OTOA
387195,16:21698948:G>A,NM_144672.3:c.614G>A,NP_653273.3:p.Arg205His,7/28,\N,Likely benign,\N,missense_variant,10.37,\N,\N,OTOA
387196,16:21698949:C>T,NM_144672.3:c.615C>T,NP_653273.3:p.Arg205=,7/28,\N,Benign,\N,synonymous_variant,12.46,0.0444444,OTO_ES_AF,OTOA
387197,16:21698950:G>A,NM_144672.3:c.616G>A,NP_653273.3:p.Glu206Lys,7/28,\N,Likely benign,\N,missense_variant,20.9,0.000116279,EVS_EA_AF,OTOA
387198,16:21698952:G>A,NM_144672.3:c.618G>A,NP_653273.3:p.Glu206=,7/28,\N,Unknown significance,\N,synonymous_variant,2.436,0.00114416,EXAC_OTH_AF,OTOA
387199,16:21698962:A>G,NM_144672.3:c.628A>G,NP_653273.3:p.Lys210Glu,7/28,\N,Unknown significance,\N,missense_variant,24.4,0.0000154064,EXAC_NFE_AF,OTOA
387200,16:21698971:T>A,NM_144672.3:c.635+2T>A,\N,\N,7/27,Unknown significance,\N,splice_donor_variant,20.2,0.000373042,EXAC_SAS_AF,OTOA
387201,16:21698974:G>A,NM_144672.3:c.635+5G>A,\N,\N,7/27,Unknown significance,\N,splice_region_variant&intron_variant,9.374,0.0000165904,EXAC_NFE_AF,OTOA
387202,16:21698984:C>T,NM_144672.3:c.635+15C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.802,0.00130845,EXAC_NFE_AF,OTOA
387203,16:21698985:G>A,NM_144672.3:c.635+16G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.247,0.0000388018,EXAC_NFE_AF,OTOA
387204,16:21698988:C>CT,NM_144672.3:c.635+37dup,\N,\N,7/27,Benign,\N,intron_variant,1.486,0.185095,EXAC_SAS_AF,OTOA
387205,16:21698988:C>CTT,NM_144672.3:c.635+36_635+37dup,\N,\N,7/27,Benign,\N,intron_variant,1.382,0.037037,EXAC_OTH_AF,OTOA
387206,16:21698988:C>CTTT,NM_144672.3:c.635+35_635+37dup,\N,\N,7/27,Benign,\N,intron_variant,1.283,0.005026,EXAC_SAS_AF,OTOA
387207,16:21698988:CT>C,NM_144672.3:c.635+37del,\N,\N,7/27,Benign,\N,intron_variant,1.853,0.268111,EXAC_SAS_AF,OTOA
387208,16:21698988:CTT>C,NM_144672.3:c.635+36_635+37del,\N,\N,7/27,Benign,\N,intron_variant,1.88,0.0379913,EXAC_NFE_AF,OTOA
387209,16:21698988:CTTTTTT>C,NM_144672.3:c.635+32_635+37del,\N,\N,7/27,Unknown significance,\N,intron_variant,2.859,0.00363901,EXAC_NFE_AF,OTOA
387210,16:21698989:T>A,NM_144672.3:c.635+20T>A,\N,\N,7/27,Unknown significance,\N,intron_variant,4.35,\N,\N,OTOA
387211,16:21698990:T>A,NM_144672.3:c.635+21T>A,\N,\N,7/27,Unknown significance,\N,intron_variant,2.289,0.000322373,EXAC_SAS_AF,OTOA
387212,16:21699000:T>G,NM_144672.3:c.635+31T>G,\N,\N,7/27,Unknown significance,\N,intron_variant,2.708,0.0000665602,EXAC_NFE_AF,OTOA
387213,16:21699014:A>G,NM_144672.3:c.635+45A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,5.817,0.000067769,EXAC_NFE_AF,OTOA
387214,16:21699015:G>A,NM_144672.3:c.635+46G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,5.561,0.000963391,EXAC_EAS_AF,OTOA
387215,16:21699027:C>T,NM_144672.3:c.635+58C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,2.127,\N,\N,OTOA
387216,16:21699068:A>C,NM_144672.3:c.635+99A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,3.378,0.0014,1KG_AMR_AF,OTOA
387217,16:21699098:C>T,NM_144672.3:c.635+129C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,4.91,0.001,1KG_EAS_AF,OTOA
387218,16:21699205:G>A,NM_144672.3:c.635+236G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.265,0.0023,1KG_AFR_AF,OTOA
387219,16:21699228:A>T,NM_144672.3:c.635+259A>T,\N,\N,7/27,Unknown significance,\N,intron_variant,3.792,\N,\N,OTOA
387220,16:21699239:C>T,NM_144672.3:c.635+270C>T,\N,\N,7/27,Benign,\N,intron_variant,4.038,0.0565,1KG_EAS_AF,OTOA
387221,16:21699267:G>C,NM_144672.3:c.635+298G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.373,0.0014,1KG_AMR_AF,OTOA
387222,16:21699286:C>T,NM_144672.3:c.635+317C>T,\N,\N,7/27,Benign,\N,intron_variant,2.795,0.0565,1KG_EAS_AF,OTOA
387223,16:21699328:C>T,NM_144672.3:c.635+359C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.053,\N,\N,OTOA
387224,16:21699329:G>A,NM_144672.3:c.635+360G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,1.875,0.001,1KG_EUR_AF,OTOA
387225,16:21699347:C>A,NM_144672.3:c.635+378C>A,\N,\N,7/27,Unknown significance,\N,intron_variant,2.432,0.0008,1KG_AFR_AF,OTOA
387226,16:21699360:A>C,NM_144672.3:c.635+391A>C,\N,\N,7/27,Benign,\N,intron_variant,1.656,0.006,1KG_EAS_AF,OTOA
387227,16:21699383:G>A,NM_144672.3:c.635+414G>A,\N,\N,7/27,Benign,\N,intron_variant,5.47,0.0069,1KG_EAS_AF,OTOA
387228,16:21699395:G>A,NM_144672.3:c.635+426G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,2.152,\N,\N,OTOA
387229,16:21699407:A>C,NM_144672.3:c.635+438A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,1.718,\N,\N,OTOA
387230,16:21699448:C>T,NM_144672.3:c.635+479C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,1.278,\N,\N,OTOA
387231,16:21699460:C>T,NM_144672.3:c.635+491C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,3.405,\N,\N,OTOA
387232,16:21699537:C>T,NM_144672.3:c.635+568C>T,\N,\N,7/27,Benign,\N,intron_variant,1.405,0.0151,1KG_AFR_AF,OTOA
387233,16:21699538:G>A,NM_144672.3:c.635+569G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.418,0.0008,1KG_AFR_AF,OTOA
387234,16:21699548:A>C,NM_144672.3:c.635+579A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,1.685,\N,\N,OTOA
387235,16:21699582:G>A,NM_144672.3:c.635+613G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.22,0.0029,1KG_AMR_AF,OTOA
387236,16:21699607:G>T,NM_144672.3:c.635+638G>T,\N,\N,7/27,Unknown significance,\N,intron_variant,3.676,\N,\N,OTOA
387237,16:21699623:T>C,NM_144672.3:c.635+654T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,2.554,\N,\N,OTOA
387238,16:21699642:G>A,NM_144672.3:c.635+673G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.413,\N,\N,OTOA
387239,16:21699657:C>T,NM_144672.3:c.635+688C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.182,0.001,1KG_EUR_AF|1KG_SAS_AF,OTOA
387240,16:21699689:G>A,NM_144672.3:c.635+720G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.963,\N,\N,OTOA
387241,16:21699706:T>A,NM_144672.3:c.635+737T>A,\N,\N,7/27,Benign,\N,intron_variant,2.686,0.0092,1KG_SAS_AF,OTOA
387242,16:21699708:T>TCAAAAA,NM_144672.3:c.635+750_635+755dup,\N,\N,7/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387243,16:21699717:AAAAC>A,NM_144672.3:c.635+760_635+763del,\N,\N,7/27,Benign,\N,intron_variant,\N,0.0092,1KG_SAS_AF,OTOA
387244,16:21699731:A>AC,NM_144672.3:c.635+762_635+763insC,\N,\N,7/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387245,16:21699732:A>AC,NM_144672.3:c.635+763_635+764insC,\N,\N,7/27,Benign,\N,intron_variant,0.039,0.0565,1KG_EAS_AF,OTOA
387246,16:21699747:A>C,NM_144672.3:c.635+778A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.104,0.003,1KG_EAS_AF,OTOA
387247,16:21699749:A>C,NM_144672.3:c.635+780A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.441,\N,\N,OTOA
387248,16:21699780:G>A,NM_144672.3:c.635+811G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,4.512,\N,\N,OTOA
387249,16:21699804:T>C,NM_144672.3:c.635+835T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,13.17,0.001,1KG_EUR_AF,OTOA
387250,16:21699852:T>C,NM_144672.3:c.635+883T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,1.499,0.001,1KG_EAS_AF,OTOA
387251,16:21699883:G>A,NM_144672.3:c.635+914G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,1.044,0.0008,1KG_AFR_AF,OTOA
387252,16:21699886:T>C,NM_144672.3:c.635+917T>C,\N,\N,7/27,Benign,\N,intron_variant,0.824,0.0072,1KG_SAS_AF,OTOA
387253,16:21699898:G>A,NM_144672.3:c.635+929G>A,\N,\N,7/27,Benign,\N,intron_variant,1.19,0.0565,1KG_EAS_AF,OTOA
387254,16:21699908:G>A,NM_144672.3:c.635+939G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.363,0.0008,1KG_AFR_AF,OTOA
387255,16:21699935:A>G,NM_144672.3:c.635+966A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,0.933,0.001,1KG_EAS_AF,OTOA
387256,16:21699961:G>A,NM_144672.3:c.635+992G>A,\N,\N,7/27,Benign,\N,intron_variant,0.539,0.006,1KG_EAS_AF,OTOA
387257,16:21699978:T>C,NM_144672.3:c.635+1009T>C,\N,\N,7/27,Benign,\N,intron_variant,0.662,0.0439,1KG_AFR_AF,OTOA
387258,16:21699989:C>T,NM_144672.3:c.635+1020C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.29,0.001,1KG_SAS_AF,OTOA
387259,16:21699990:G>A,NM_144672.3:c.635+1021G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.679,\N,\N,OTOA
387260,16:21700020:C>A,NM_144672.3:c.635+1051C>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.277,0.0015,1KG_AFR_AF,OTOA
387261,16:21700048:G>T,NM_144672.3:c.635+1079G>T,\N,\N,7/27,Unknown significance,\N,intron_variant,1.253,\N,\N,OTOA
387262,16:21700058:C>T,NM_144672.3:c.635+1089C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,7.582,\N,\N,OTOA
387263,16:21700109:C>T,NM_144672.3:c.635+1140C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,1.839,\N,\N,OTOA
387264,16:21700122:C>T,NM_144672.3:c.635+1153C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,2.386,0.001,1KG_EUR_AF,OTOA
387265,16:21700163:A>C,NM_144672.3:c.635+1194A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.213,0.001,1KG_EAS_AF,OTOA
387266,16:21700164:C>T,NM_144672.3:c.635+1195C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.152,0.0008,1KG_AFR_AF,OTOA
387267,16:21700172:T>C,NM_144672.3:c.635+1203T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,1.138,0.0008,1KG_AFR_AF,OTOA
387268,16:21700209:G>C,NM_144672.3:c.635+1240G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.131,0.0008,1KG_AFR_AF,OTOA
387269,16:21700239:G>T,NM_144672.3:c.635+1270G>T,\N,\N,7/27,Benign,\N,intron_variant,1.809,0.0089,1KG_EAS_AF,OTOA
387270,16:21700259:C>T,NM_144672.3:c.635+1290C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,7.379,0.002,1KG_EAS_AF,OTOA
387271,16:21700273:T>A,NM_144672.3:c.635+1304T>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.415,\N,\N,OTOA
387272,16:21700273:T>C,NM_144672.3:c.635+1304T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.076,\N,\N,OTOA
387273,16:21700273:T>G,NM_144672.3:c.635+1304T>G,\N,\N,7/27,Unknown significance,\N,intron_variant,0.162,\N,\N,OTOA
387274,16:21700374:A>G,NM_144672.3:c.635+1405A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,2.031,0.001,1KG_EAS_AF,OTOA
387275,16:21700384:G>T,NM_144672.3:c.635+1415G>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.277,0.001,1KG_SAS_AF,OTOA
387276,16:21700398:C>T,NM_144672.3:c.635+1429C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,1.551,\N,\N,OTOA
387277,16:21700415:T>C,NM_144672.3:c.635+1446T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,3.454,0.0008,1KG_AFR_AF,OTOA
387278,16:21700421:A>C,NM_144672.3:c.635+1452A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,2.178,\N,\N,OTOA
387279,16:21700432:C>T,NM_144672.3:c.635+1463C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,1.822,\N,\N,OTOA
387280,16:21700433:A>G,NM_144672.3:c.635+1464A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,0.426,\N,\N,OTOA
387281,16:21700443:C>T,NM_144672.3:c.635+1474C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.858,0.0008,1KG_AFR_AF,OTOA
387282,16:21700450:C>CG,NM_144672.3:c.635+1482dup,\N,\N,7/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387283,16:21700450:C>T,NM_144672.3:c.635+1481C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.839,0.001,1KG_EAS_AF,OTOA
387284,16:21700477:A>G,NM_144672.3:c.635+1508A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,2.84,\N,\N,OTOA
387285,16:21700479:T>C,NM_144672.3:c.635+1510T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.918,\N,\N,OTOA
387286,16:21700490:C>T,NM_144672.3:c.635+1521C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,2.135,\N,\N,OTOA
387287,16:21700511:C>T,NM_144672.3:c.635+1542C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,7.087,\N,\N,OTOA
387288,16:21700575:T>C,NM_144672.3:c.635+1606T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.397,\N,\N,OTOA
387289,16:21700627:G>T,NM_144672.3:c.635+1658G>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.147,0.001,1KG_EUR_AF,OTOA
387290,16:21700665:A>T,NM_144672.3:c.635+1696A>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.394,0.001,1KG_EAS_AF,OTOA
387291,16:21700704:T>A,NM_144672.3:c.635+1735T>A,\N,\N,7/27,Unknown significance,\N,intron_variant,2.401,0.001,1KG_SAS_AF,OTOA
387292,16:21700726:T>C,NM_144672.3:c.635+1757T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.577,\N,\N,OTOA
387293,16:21700735:C>T,NM_144672.3:c.635+1766C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.66,\N,\N,OTOA
387294,16:21700736:G>A,NM_144672.3:c.635+1767G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.448,\N,\N,OTOA
387295,16:21700755:G>A,NM_144672.3:c.635+1786G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,5.682,0.002,1KG_SAS_AF,OTOA
387296,16:21700768:GGA>G,NM_144672.3:c.635+1807_635+1808del,\N,\N,7/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387297,16:21700768:GGAGA>G,NM_144672.3:c.635+1805_635+1808del,\N,\N,7/27,Unknown significance,\N,intron_variant,0.311,\N,\N,OTOA
387298,16:21700773:G>C,NM_144672.3:c.635+1804G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.202,\N,\N,OTOA
387299,16:21700784:G>C,NM_144672.3:c.635+1815G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,1.926,0.001,1KG_SAS_AF,OTOA
387300,16:21700805:G>A,NM_144672.3:c.635+1836G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,1.968,\N,\N,OTOA
387301,16:21700808:G>C,NM_144672.3:c.635+1839G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.077,0.0029,1KG_AMR_AF,OTOA
387302,16:21700853:A>C,NM_144672.3:c.635+1884A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,5.247,0.001,1KG_EUR_AF,OTOA
387303,16:21700861:A>G,NM_144672.3:c.635+1892A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,6.433,\N,\N,OTOA
387304,16:21700886:T>A,NM_144672.3:c.635+1917T>A,\N,\N,7/27,Unknown significance,\N,intron_variant,20.9,0.002,1KG_EUR_AF,OTOA
387305,16:21700911:C>T,NM_144672.3:c.635+1942C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,12.43,0.001,1KG_EAS_AF,OTOA
387306,16:21700915:G>C,NM_144672.3:c.635+1946G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,11.33,\N,\N,OTOA
387307,16:21700939:G>A,NM_144672.3:c.636-1966G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,2.963,0.0023,1KG_AFR_AF,OTOA
387308,16:21700965:G>T,NM_144672.3:c.636-1940G>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.016,0.001,1KG_EAS_AF,OTOA
387309,16:21701007:G>A,NM_144672.3:c.636-1898G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.108,\N,\N,OTOA
387310,16:21701022:T>C,NM_144672.3:c.636-1883T>C,\N,\N,7/27,Benign,\N,intron_variant,1.096,0.0068,1KG_AFR_AF,OTOA
387311,16:21701063:A>G,NM_144672.3:c.636-1842A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,3.532,\N,\N,OTOA
387312,16:21701071:A>C,NM_144672.3:c.636-1834A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.92,\N,\N,OTOA
387313,16:21701072:T>C,NM_144672.3:c.636-1833T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.967,\N,\N,OTOA
387314,16:21701075:C>T,NM_144672.3:c.636-1830C>T,\N,\N,7/27,Benign,\N,intron_variant,1.275,0.0153,1KG_SAS_AF,OTOA
387315,16:21701126:C>T,NM_144672.3:c.636-1779C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,8.636,\N,\N,OTOA
387316,16:21701182:T>C,NM_144672.3:c.636-1723T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.384,\N,\N,OTOA
387317,16:21701197:G>C,NM_144672.3:c.636-1708G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,4.917,\N,\N,OTOA
387318,16:21701234:T>A,NM_144672.3:c.636-1671T>A,\N,\N,7/27,Unknown significance,\N,intron_variant,8.175,0.0008,1KG_AFR_AF,OTOA
387319,16:21701243:G>A,NM_144672.3:c.636-1662G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,3.797,0.0023,1KG_AFR_AF,OTOA
387320,16:21701249:C>T,NM_144672.3:c.636-1656C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.013,0.001,1KG_SAS_AF,OTOA
387321,16:21701335:T>C,NM_144672.3:c.636-1570T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,7.095,0.001,1KG_SAS_AF,OTOA
387322,16:21701380:A>G,NM_144672.3:c.636-1525A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,7.342,\N,\N,OTOA
387323,16:21701399:A>G,NM_144672.3:c.636-1506A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,12.6,0.0014,1KG_AMR_AF,OTOA
387324,16:21701485:A>T,NM_144672.3:c.636-1420A>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.58,\N,\N,OTOA
387325,16:21701517:G>A,NM_144672.3:c.636-1388G>A,\N,\N,7/27,Benign,\N,intron_variant,1.185,0.9977,1KG_AFR_AF,OTOA
387326,16:21701517:G>C,NM_144672.3:c.636-1388G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.154,\N,\N,OTOA
387327,16:21701538:C>T,NM_144672.3:c.636-1367C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.178,0.002,1KG_EAS_AF,OTOA
387328,16:21701539:G>A,NM_144672.3:c.636-1366G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,1.271,0.0014,1KG_AMR_AF,OTOA
387329,16:21701567:G>A,NM_144672.3:c.636-1338G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.213,0.001,1KG_EAS_AF,OTOA
387330,16:21701592:T>C,NM_144672.3:c.636-1313T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,6.077,\N,\N,OTOA
387331,16:21701638:G>GC,NM_144672.3:c.636-1267_636-1266insC,\N,\N,7/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387332,16:21701639:A>G,NM_144672.3:c.636-1266A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,1.974,\N,\N,OTOA
387333,16:21701647:C>T,NM_144672.3:c.636-1258C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,8.562,0.0029,1KG_AMR_AF,OTOA
387334,16:21701653:G>C,NM_144672.3:c.636-1252G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,4.555,0.0014,1KG_AMR_AF,OTOA
387335,16:21701660:C>T,NM_144672.3:c.636-1245C>T,\N,\N,7/27,Benign,\N,intron_variant,7.594,0.0565,1KG_EAS_AF,OTOA
387336,16:21701664:C>T,NM_144672.3:c.636-1241C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,6.771,\N,\N,OTOA
387337,16:21701674:C>T,NM_144672.3:c.636-1231C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,4.383,\N,\N,OTOA
387338,16:21701700:G>T,NM_144672.3:c.636-1205G>T,\N,\N,7/27,Benign,\N,intron_variant,0.988,0.1316,1KG_AFR_AF,OTOA
387339,16:21701719:T>C,NM_144672.3:c.636-1186T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,2.153,0.0008,1KG_AFR_AF,OTOA
387340,16:21701741:C>A,NM_144672.3:c.636-1164C>A,\N,\N,7/27,Unknown significance,\N,intron_variant,3.585,0.001,1KG_EAS_AF,OTOA
387341,16:21701749:A>G,NM_144672.3:c.636-1156A>G,\N,\N,7/27,Benign,\N,intron_variant,2.587,0.0885,1KG_AFR_AF,OTOA
387342,16:21701784:C>T,NM_144672.3:c.636-1121C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,2.456,0.003,1KG_EAS_AF,OTOA
387343,16:21701813:G>C,NM_144672.3:c.636-1092G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,4.888,\N,\N,OTOA
387344,16:21701847:G>A,NM_144672.3:c.636-1058G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,4.603,0.001,1KG_SAS_AF,OTOA
387345,16:21701865:A>T,NM_144672.3:c.636-1040A>T,\N,\N,7/27,Unknown significance,\N,intron_variant,3.526,\N,\N,OTOA
387346,16:21701866:T>C,NM_144672.3:c.636-1039T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,4.658,\N,\N,OTOA
387347,16:21701878:G>A,NM_144672.3:c.636-1027G>A,\N,\N,7/27,Benign,\N,intron_variant,7.531,0.007,1KG_EUR_AF,OTOA
387348,16:21701918:A>T,NM_144672.3:c.636-987A>T,\N,\N,7/27,Unknown significance,\N,intron_variant,7.218,0.0008,1KG_AFR_AF,OTOA
387349,16:21702011:A>C,NM_144672.3:c.636-894A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.003,\N,\N,OTOA
387350,16:21702011:A>T,NM_144672.3:c.636-894A>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.003,\N,\N,OTOA
387351,16:21702029:G>A,NM_144672.3:c.636-876G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.005,0.001,1KG_EUR_AF,OTOA
387352,16:21702070:A>C,NM_144672.3:c.636-835A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,4.576,\N,\N,OTOA
387353,16:21702091:T>A,NM_144672.3:c.636-814T>A,\N,\N,7/27,Unknown significance,\N,intron_variant,11,0.0008,1KG_AFR_AF,OTOA
387354,16:21702120:A>C,NM_144672.3:c.636-785A>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.412,0.0023,1KG_AFR_AF,OTOA
387355,16:21702148:T>A,NM_144672.3:c.636-757T>A,\N,\N,7/27,Unknown significance,\N,intron_variant,1.879,0.002,1KG_SAS_AF,OTOA
387356,16:21702154:T>C,NM_144672.3:c.636-751T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.835,\N,\N,OTOA
387357,16:21702184:C>T,NM_144672.3:c.636-721C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,1.005,\N,\N,OTOA
387358,16:21702206:A>G,NM_144672.3:c.636-699A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,1.831,0.0008,1KG_AFR_AF,OTOA
387359,16:21702268:T>C,NM_144672.3:c.636-637T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,1.078,0.001,1KG_SAS_AF,OTOA
387360,16:21702336:C>T,NM_144672.3:c.636-569C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.602,0.001,1KG_EAS_AF,OTOA
387361,16:21702345:T>C,NM_144672.3:c.636-560T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,1.31,\N,\N,OTOA
387362,16:21702383:G>A,NM_144672.3:c.636-522G>A,\N,\N,7/27,Benign,\N,intron_variant,1.122,0.0565,1KG_EAS_AF,OTOA
387363,16:21702396:C>T,NM_144672.3:c.636-509C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,0.528,0.0015,1KG_AFR_AF,OTOA
387364,16:21702405:T>C,NM_144672.3:c.636-500T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.342,0.0008,1KG_AFR_AF,OTOA
387365,16:21702457:G>C,NM_144672.3:c.636-448G>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.271,\N,\N,OTOA
387366,16:21702461:C>T,NM_144672.3:c.636-444C>T,\N,\N,7/27,Benign,\N,intron_variant,0.18,0.2943,1KG_AFR_AF,OTOA
387367,16:21702477:T>A,NM_144672.3:c.636-428T>A,\N,\N,7/27,Unknown significance,\N,intron_variant,3.9,0.001,1KG_EUR_AF,OTOA
387368,16:21702498:G>C,NM_144672.3:c.636-407G>C,\N,\N,7/27,Benign,\N,intron_variant,0.06,0.0565,1KG_EAS_AF,OTOA
387369,16:21702518:T>C,NM_144672.3:c.636-387T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.87,0.001,1KG_SAS_AF,OTOA
387370,16:21702527:A>G,NM_144672.3:c.636-378A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,1.332,0.0014,1KG_AMR_AF,OTOA
387371,16:21702533:T>C,NM_144672.3:c.636-372T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.8,\N,\N,OTOA
387372,16:21702586:A>G,NM_144672.3:c.636-319A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,0.572,\N,\N,OTOA
387373,16:21702599:G>A,NM_144672.3:c.636-306G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.22,0.003,1KG_AFR_AF,OTOA
387374,16:21702605:A>G,NM_144672.3:c.636-300A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,1.35,0.003,1KG_AFR_AF,OTOA
387375,16:21702615:A>G,NM_144672.3:c.636-290A>G,\N,\N,7/27,Unknown significance,\N,intron_variant,0.346,0.001,1KG_EUR_AF,OTOA
387376,16:21702638:T>C,NM_144672.3:c.636-267T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,0.959,\N,\N,OTOA
387377,16:21702728:G>A,NM_144672.3:c.636-177G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,2.311,0.0045,1KG_AFR_AF,OTOA
387378,16:21702746:C>A,NM_144672.3:c.636-159C>A,\N,\N,7/27,Unknown significance,\N,intron_variant,1.794,0.003,1KG_EAS_AF,OTOA
387379,16:21702766:G>A,NM_144672.3:c.636-139G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,0.013,\N,\N,OTOA
387380,16:21702845:C>A,NM_144672.3:c.636-60C>A,\N,\N,7/27,Unknown significance,\N,intron_variant,4.962,\N,\N,OTOA
387381,16:21702858:C>T,NM_144672.3:c.636-47C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,5.504,0.0000682967,EXAC_SAS_AF,OTOA
387382,16:21702860:C>T,NM_144672.3:c.636-45C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,3.524,0.0000679348,EXAC_SAS_AF,OTOA
387383,16:21702864:C>T,NM_144672.3:c.636-41C>T,\N,\N,7/27,Unknown significance,\N,intron_variant,5.684,0.000067714,EXAC_SAS_AF,OTOA
387384,16:21702870:T>G,NM_144672.3:c.636-35T>G,\N,\N,7/27,Benign,\N,intron_variant,5.735,0.0527331,EXAC_AFR_AF,OTOA
387385,16:21702873:T>G,NM_144672.3:c.636-32T>G,\N,\N,7/27,Unknown significance,\N,intron_variant,6.497,0.0000339282,EXAC_NFE_AF,OTOA
387386,16:21702878:G>A,NM_144672.3:c.636-27G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,2.324,0.000304136,EXAC_AMR_AF,OTOA
387387,16:21702883:T>C,NM_144672.3:c.636-22T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,3.765,0.0000163597,EXAC_NFE_AF,OTOA
387388,16:21702885:C>A,NM_144672.3:c.636-20C>A,\N,\N,7/27,Unknown significance,\N,intron_variant,3.087,0.0000970497,EXAC_AMR_AF,OTOA
387389,16:21702889:T>C,NM_144672.3:c.636-16T>C,\N,\N,7/27,Unknown significance,\N,intron_variant,1.713,0.0000159185,EXAC_NFE_AF,OTOA
387390,16:21702890:G>A,NM_144672.3:c.636-15G>A,\N,\N,7/27,Unknown significance,\N,intron_variant,1.73,0.0000652061,EXAC_SAS_AF,OTOA
387391,16:21702905:A>T,NM_144672.3:c.636A>T,NP_653273.3:p.Leu212=,8/28,\N,Unknown significance,\N,splice_region_variant&synonymous_variant,0.069,\N,\N,OTOA
387392,16:21702914:G>A,NM_144672.3:c.645G>A,NP_653273.3:p.Val215=,8/28,\N,Unknown significance,\N,synonymous_variant,1.712,0.0000884799,EXAC_AMR_AF,OTOA
387393,16:21702929:C>T,NM_144672.3:c.660C>T,NP_653273.3:p.Tyr220=,8/28,\N,Likely benign,\N,synonymous_variant,5.863,0.001,1KG_EUR_AF,OTOA
387394,16:21702930:G>A,NM_144672.3:c.661G>A,NP_653273.3:p.Asp221Asn,8/28,\N,Unknown significance,\N,missense_variant,24.1,0.000232558,EVS_EA_AF,OTOA
387395,16:21702933:A>G,NM_144672.3:c.664A>G,NP_653273.3:p.Lys222Glu,8/28,\N,Likely benign,\N,missense_variant,12.82,0.0000150716,EXAC_NFE_AF,OTOA
387396,16:21702938:C>G,NM_144672.3:c.669C>G,NP_653273.3:p.Thr223=,8/28,\N,Unknown significance,\N,synonymous_variant,4.883,0.000115794,EXAC_EAS_AF,OTOA
387397,16:21702940:C>T,NM_144672.3:c.671C>T,NP_653273.3:p.Ser224Leu,8/28,\N,Unknown significance,\N,missense_variant,26,0.000174734,EXAC_AMR_AF,OTOA
387398,16:21702941:G>A,NM_144672.3:c.672G>A,NP_653273.3:p.Ser224=,8/28,\N,Unknown significance,\N,synonymous_variant,7.72,0.00131027,EXAC_AMR_AF,OTOA
387399,16:21702942:G>A,NM_144672.3:c.673G>A,NP_653273.3:p.Ala225Thr,8/28,\N,Unknown significance,\N,missense_variant,22.7,0.0000150525,EXAC_NFE_AF,OTOA
387400,16:21702945:C>T,NM_144672.3:c.676C>T,NP_653273.3:p.His226Tyr,8/28,\N,Unknown significance,\N,missense_variant,17.48,0.000115821,EXAC_EAS_AF,OTOA
387401,16:21702949:C>A,NM_144672.3:c.680C>A,NP_653273.3:p.Ser227Tyr,8/28,\N,Unknown significance,\N,missense_variant,22.9,0.000116279,EVS_EA_AF,OTOA
387402,16:21702952:A>T,NM_144672.3:c.683A>T,NP_653273.3:p.Gln228Leu,8/28,\N,Unknown significance,\N,missense_variant,23.2,0.000115768,EXAC_EAS_AF,OTOA
387403,16:21702953:G>A,NM_144672.3:c.684G>A,NP_653273.3:p.Gln228=,8/28,\N,Unknown significance,\N,synonymous_variant,0.577,0.000151469,EXAC_FIN_AF,OTOA
387404,16:21702963:T>C,NM_144672.3:c.694T>C,NP_653273.3:p.Tyr232His,8/28,\N,Unknown significance,\N,missense_variant,22.6,0.0000972006,EXAC_AFR_AF,OTOA
387405,16:21702966:T>A,NM_144672.3:c.697T>A,NP_653273.3:p.Ser233Thr,8/28,\N,Likely benign,\N,missense_variant,3.817,0.0000872905,EXAC_AMR_AF,OTOA
387406,16:21702967:C>G,NM_144672.3:c.698C>G,NP_653273.3:p.Ser233Cys,8/28,\N,Likely benign,\N,missense_variant,10.6,0.0000150516,EXAC_NFE_AF,OTOA
387407,16:21702977:T>C,NM_144672.3:c.708T>C,NP_653273.3:p.Thr236=,8/28,\N,Unknown significance,\N,synonymous_variant,0.094,0.0000150702,EXAC_NFE_AF,OTOA
387408,16:21702979:G>A,NM_144672.3:c.710G>A,NP_653273.3:p.Gly237Glu,8/28,\N,Likely benign,\N,missense_variant,0.015,0.0000150816,EXAC_NFE_AF,OTOA
387409,16:21702999:A>G,NM_144672.3:c.730A>G,NP_653273.3:p.Asn244Asp,8/28,\N,Unknown significance,\N,missense_variant,9.25,0.0000151994,EXAC_NFE_AF,OTOA
387410,16:21703003:C>T,NM_144672.3:c.734C>T,NP_653273.3:p.Ala245Val,8/28,\N,Likely benign,\N,missense_variant,0.076,0.0000305111,EXAC_NFE_AF,OTOA
387411,16:21703004:C>T,NM_144672.3:c.735C>T,NP_653273.3:p.Ala245=,8/28,\N,Unknown significance,\N,synonymous_variant,6.655,0.000116279,EVS_EA_AF,OTOA
387412,16:21703011:G>T,NM_144672.3:c.739+3G>T,\N,\N,8/27,Unknown significance,\N,splice_region_variant&intron_variant,5.177,\N,\N,OTOA
387413,16:21703014:C>G,NM_144672.3:c.739+6C>G,\N,\N,8/27,Unknown significance,\N,splice_region_variant&intron_variant,2.072,0.0000154923,EXAC_NFE_AF,OTOA
387414,16:21703019:A>G,NM_144672.3:c.739+11A>G,\N,\N,8/27,Likely benign,\N,intron_variant,2.859,0.0014,1KG_AMR_AF,OTOA
387415,16:21703022:T>A,NM_144672.3:c.739+14T>A,\N,\N,8/27,Unknown significance,\N,intron_variant,4.906,0.0000638733,EXAC_SAS_AF,OTOA
387416,16:21703032:G>A,NM_144672.3:c.739+24G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,6.894,0.000123031,EXAC_EAS_AF,OTOA
387417,16:21703032:G>C,NM_144672.3:c.739+24G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,3.378,0.0000647417,EXAC_SAS_AF,OTOA
387418,16:21703041:T>C,NM_144672.3:c.739+33T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,6.916,0.000227376,EVS_AA_AF,OTOA
387419,16:21703048:A>C,NM_144672.3:c.739+40A>C,\N,\N,8/27,Unknown significance,\N,intron_variant,2.616,0.000105485,EXAC_AFR_AF,OTOA
387420,16:21703049:G>A,NM_144672.3:c.739+41G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,2.785,0.0000170381,EXAC_NFE_AF,OTOA
387421,16:21703052:T>C,NM_144672.3:c.739+44T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,2.642,0.000106998,EXAC_AFR_AF,OTOA
387422,16:21703053:A>G,NM_144672.3:c.739+45A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,4.234,0.000017369,EXAC_NFE_AF,OTOA
387423,16:21703058:C>T,NM_144672.3:c.739+50C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,4.41,0.000166003,EXAC_FIN_AF,OTOA
387424,16:21703075:C>T,NM_144672.3:c.739+67C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,5.546,\N,\N,OTOA
387425,16:21703167:C>T,NM_144672.3:c.739+159C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,6.73,\N,\N,OTOA
387426,16:21703182:G>A,NM_144672.3:c.739+174G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.979,0.001,1KG_EAS_AF|1KG_EUR_AF,OTOA
387427,16:21703194:C>T,NM_144672.3:c.739+186C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.604,0.0014,1KG_AMR_AF,OTOA
387428,16:21703230:A>G,NM_144672.3:c.739+222A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,4.046,\N,\N,OTOA
387429,16:21703244:G>A,NM_144672.3:c.739+236G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,3.299,0.002,1KG_EAS_AF,OTOA
387430,16:21703299:G>A,NM_144672.3:c.739+291G>A,\N,\N,8/27,Benign,\N,intron_variant,7.53,0.1536,1KG_AFR_AF,OTOA
387431,16:21703347:A>G,NM_144672.3:c.739+339A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,2.318,0.0008,1KG_AFR_AF,OTOA
387432,16:21703351:T>C,NM_144672.3:c.739+343T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,3.901,\N,\N,OTOA
387433,16:21703374:G>A,NM_144672.3:c.739+366G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.028,0.001,1KG_EUR_AF,OTOA
387434,16:21703385:C>T,NM_144672.3:c.739+377C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.26,0.001,1KG_EAS_AF|1KG_SAS_AF,OTOA
387435,16:21703431:G>A,NM_144672.3:c.739+423G>A,\N,\N,8/27,Benign,\N,intron_variant,0.723,0.0068,1KG_AFR_AF,OTOA
387436,16:21703435:G>T,NM_144672.3:c.739+427G>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.275,0.001,1KG_SAS_AF,OTOA
387437,16:21703442:G>A,NM_144672.3:c.739+434G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.383,\N,\N,OTOA
387438,16:21703453:G>C,NM_144672.3:c.739+445G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,1.102,0.0008,1KG_AFR_AF,OTOA
387439,16:21703455:C>T,NM_144672.3:c.739+447C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,3.924,0.0008,1KG_AFR_AF,OTOA
387440,16:21703460:C>T,NM_144672.3:c.739+452C>T,\N,\N,8/27,Benign,\N,intron_variant,2.879,0.0113,1KG_AFR_AF,OTOA
387441,16:21703461:G>A,NM_144672.3:c.739+453G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.702,0.0008,1KG_AFR_AF,OTOA
387442,16:21703504:C>T,NM_144672.3:c.739+496C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.259,\N,\N,OTOA
387443,16:21703506:G>A,NM_144672.3:c.739+498G>A,\N,\N,8/27,Benign,\N,intron_variant,2.403,0.9672,1KG_EUR_AF,OTOA
387444,16:21703519:G>A,NM_144672.3:c.739+511G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.826,0.001,1KG_EUR_AF,OTOA
387445,16:21703571:T>C,NM_144672.3:c.739+563T>C,\N,\N,8/27,Benign,\N,intron_variant,1.881,0.9761,1KG_EUR_AF,OTOA
387446,16:21703572:G>C,NM_144672.3:c.739+564G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,0.05,0.001,1KG_EUR_AF,OTOA
387447,16:21703607:C>T,NM_144672.3:c.739+599C>T,\N,\N,8/27,Benign,\N,intron_variant,1.22,0.007,1KG_EUR_AF,OTOA
387448,16:21703634:C>T,NM_144672.3:c.739+626C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.148,\N,\N,OTOA
387449,16:21703647:C>T,NM_144672.3:c.739+639C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,2.682,0.002,1KG_EAS_AF,OTOA
387450,16:21703648:GA>G,NM_144672.3:c.739+653del,\N,\N,8/27,Unknown significance,\N,intron_variant,0.593,\N,\N,OTOA
387451,16:21703660:A>G,NM_144672.3:c.739+652A>G,\N,\N,8/27,Benign,\N,intron_variant,1.737,0.0072,1KG_SAS_AF,OTOA
387452,16:21703688:T>C,NM_144672.3:c.739+680T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,3.206,\N,\N,OTOA
387453,16:21703729:C>T,NM_144672.3:c.739+721C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.246,\N,\N,OTOA
387454,16:21703730:G>A,NM_144672.3:c.739+722G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.084,0.0008,1KG_AFR_AF,OTOA
387455,16:21703755:C>A,NM_144672.3:c.739+747C>A,\N,\N,8/27,Unknown significance,\N,intron_variant,4.285,\N,\N,OTOA
387456,16:21703772:A>G,NM_144672.3:c.739+764A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,8.079,0.001,1KG_EUR_AF,OTOA
387457,16:21703819:T>C,NM_144672.3:c.739+811T>C,\N,\N,8/27,Benign,\N,intron_variant,4.718,0.115,1KG_AFR_AF,OTOA
387458,16:21703861:A>T,NM_144672.3:c.739+853A>T,\N,\N,8/27,Unknown significance,\N,intron_variant,4.931,0.001,1KG_EAS_AF,OTOA
387459,16:21703895:C>CG,NM_144672.3:c.739+889dup,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387460,16:21703937:C>A,NM_144672.3:c.739+929C>A,\N,\N,8/27,Unknown significance,\N,intron_variant,3.992,0.001,1KG_EUR_AF,OTOA
387461,16:21703959:GC>G,NM_144672.3:c.739+953del,\N,\N,8/27,Benign,\N,intron_variant,0.68,0.0317,1KG_SAS_AF,OTOA
387462,16:21703964:G>A,NM_144672.3:c.739+956G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.811,\N,\N,OTOA
387463,16:21703967:G>T,NM_144672.3:c.739+959G>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.609,\N,\N,OTOA
387464,16:21703971:G>A,NM_144672.3:c.739+963G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.626,\N,\N,OTOA
387465,16:21703977:G>A,NM_144672.3:c.739+969G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.747,\N,\N,OTOA
387466,16:21704110:G>A,NM_144672.3:c.739+1102G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.123,0.001,1KG_EAS_AF,OTOA
387467,16:21704133:C>G,NM_144672.3:c.739+1125C>G,\N,\N,8/27,Unknown significance,\N,intron_variant,0.213,\N,\N,OTOA
387468,16:21704184:G>A,NM_144672.3:c.739+1176G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,2.736,\N,\N,OTOA
387469,16:21704205:T>A,NM_144672.3:c.739+1197T>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.117,\N,\N,OTOA
387470,16:21704248:C>A,NM_144672.3:c.739+1240C>A,\N,\N,8/27,Unknown significance,\N,intron_variant,3.386,\N,\N,OTOA
387471,16:21704248:C>CA,NM_144672.3:c.739+1258dup,\N,\N,8/27,Unknown significance,\N,intron_variant,3.278,\N,\N,OTOA
387472,16:21704248:C>CAA,NM_144672.3:c.739+1257_739+1258dup,\N,\N,8/27,Unknown significance,\N,intron_variant,3.09,\N,\N,OTOA
387473,16:21704248:C>CAAA,NM_144672.3:c.739+1256_739+1258dup,\N,\N,8/27,Unknown significance,\N,intron_variant,2.927,\N,\N,OTOA
387474,16:21704263:A>AAG,NM_144672.3:c.739+1256_739+1257insGA,\N,\N,8/27,Unknown significance,\N,intron_variant,0.03,\N,\N,OTOA
387475,16:21704267:G>A,NM_144672.3:c.739+1259G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.105,\N,\N,OTOA
387476,16:21704274:A>G,NM_144672.3:c.739+1266A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,0.691,0.0015,1KG_AFR_AF,OTOA
387477,16:21704288:A>C,NM_144672.3:c.739+1280A>C,\N,\N,8/27,Benign,\N,intron_variant,0.251,0.0317,1KG_EAS_AF,OTOA
387478,16:21704290:T>C,NM_144672.3:c.739+1282T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,0.032,\N,\N,OTOA
387479,16:21704292:G>A,NM_144672.3:c.739+1284G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.309,\N,\N,OTOA
387480,16:21704303:C>T,NM_144672.3:c.739+1295C>T,\N,\N,8/27,Benign,\N,intron_variant,1.241,0.0278,1KG_EUR_AF,OTOA
387481,16:21704304:G>A,NM_144672.3:c.739+1296G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.249,0.001,1KG_SAS_AF,OTOA
387482,16:21704347:G>A,NM_144672.3:c.739+1339G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.2,\N,\N,OTOA
387483,16:21704373:T>C,NM_144672.3:c.739+1365T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,7.002,0.001,1KG_EAS_AF,OTOA
387484,16:21704382:C>A,NM_144672.3:c.739+1374C>A,\N,\N,8/27,Unknown significance,\N,intron_variant,6.578,\N,\N,OTOA
387485,16:21704454:G>A,NM_144672.3:c.739+1446G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.247,0.0008,1KG_AFR_AF,OTOA
387486,16:21704457:C>T,NM_144672.3:c.739+1449C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.16,0.0014,1KG_AMR_AF,OTOA
387487,16:21704458:G>A,NM_144672.3:c.739+1450G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.33,\N,\N,OTOA
387488,16:21704475:C>T,NM_144672.3:c.739+1467C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,2.849,\N,\N,OTOA
387489,16:21704485:T>C,NM_144672.3:c.739+1477T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,2.101,0.0008,1KG_AFR_AF,OTOA
387490,16:21704517:A>C,NM_144672.3:c.739+1509A>C,\N,\N,8/27,Benign,\N,intron_variant,0.995,0.0061,1KG_AFR_AF,OTOA
387491,16:21704524:G>A,NM_144672.3:c.739+1516G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,2.536,\N,\N,OTOA
387492,16:21704536:G>C,NM_144672.3:c.739+1528G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,0.104,\N,\N,OTOA
387493,16:21704573:A>T,NM_144672.3:c.739+1565A>T,\N,\N,8/27,Unknown significance,\N,intron_variant,1.474,\N,\N,OTOA
387494,16:21704592:G>GCAAA,NM_144672.3:c.739+1605_739+1608dup,\N,\N,8/27,Unknown significance,\N,intron_variant,0.073,\N,\N,OTOA
387495,16:21704592:GCAAA>G,NM_144672.3:c.739+1605_739+1608del,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387496,16:21704620:G>A,NM_144672.3:c.739+1612G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.879,0.0015,1KG_AFR_AF,OTOA
387497,16:21704633:A>C,NM_144672.3:c.739+1625A>C,\N,\N,8/27,Unknown significance,\N,intron_variant,4.442,0.001,1KG_EAS_AF,OTOA
387498,16:21704696:T>A,NM_144672.3:c.739+1688T>A,\N,\N,8/27,Unknown significance,\N,intron_variant,7.527,\N,\N,OTOA
387499,16:21704746:T>C,NM_144672.3:c.739+1738T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,3.473,\N,\N,OTOA
387500,16:21704756:T>C,NM_144672.3:c.739+1748T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,1.892,0.0008,1KG_AFR_AF,OTOA
387501,16:21704762:A>G,NM_144672.3:c.739+1754A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,0.579,0.001,1KG_EAS_AF,OTOA
387502,16:21704768:CA>C,NM_144672.3:c.739+1764del,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387503,16:21704784:C>T,NM_144672.3:c.739+1776C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.593,\N,\N,OTOA
387504,16:21704836:T>A,NM_144672.3:c.739+1828T>A,\N,\N,8/27,Unknown significance,\N,intron_variant,3.803,\N,\N,OTOA
387505,16:21704869:C>T,NM_144672.3:c.739+1861C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.816,0.001,1KG_SAS_AF,OTOA
387506,16:21704892:C>T,NM_144672.3:c.739+1884C>T,\N,\N,8/27,Benign,\N,intron_variant,10.81,0.0575,1KG_EAS_AF,OTOA
387507,16:21704959:G>C,NM_144672.3:c.739+1951G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,1.15,0.001,1KG_EAS_AF,OTOA
387508,16:21704965:C>A,NM_144672.3:c.739+1957C>A,\N,\N,8/27,Unknown significance,\N,intron_variant,2.719,0.001,1KG_EUR_AF,OTOA
387509,16:21704966:A>C,NM_144672.3:c.739+1958A>C,\N,\N,8/27,Unknown significance,\N,intron_variant,0.422,0.002,1KG_EUR_AF,OTOA
387510,16:21704970:T>G,NM_144672.3:c.739+1962T>G,\N,\N,8/27,Unknown significance,\N,intron_variant,1.965,\N,\N,OTOA
387511,16:21704985:C>A,NM_144672.3:c.739+1977C>A,\N,\N,8/27,Unknown significance,\N,intron_variant,3.004,\N,\N,OTOA
387512,16:21705016:G>A,NM_144672.3:c.739+2008G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.681,0.001,1KG_EAS_AF,OTOA
387513,16:21705108:G>A,NM_144672.3:c.739+2100G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,2.216,\N,\N,OTOA
387514,16:21705112:G>A,NM_144672.3:c.739+2104G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.303,0.001,1KG_EUR_AF,OTOA
387515,16:21705187:G>A,NM_144672.3:c.739+2179G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.622,\N,\N,OTOA
387516,16:21705197:A>G,NM_144672.3:c.739+2189A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,0.082,\N,\N,OTOA
387517,16:21705204:A>G,NM_144672.3:c.739+2196A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,0.872,\N,\N,OTOA
387518,16:21705236:T>C,NM_144672.3:c.739+2228T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,3.606,\N,\N,OTOA
387519,16:21705277:C>T,NM_144672.3:c.739+2269C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,9.596,0.001,1KG_SAS_AF,OTOA
387520,16:21705292:A>G,NM_144672.3:c.739+2284A>G,\N,\N,8/27,Benign,\N,intron_variant,0.862,0.0069,1KG_EAS_AF,OTOA
387521,16:21705312:G>A,NM_144672.3:c.739+2304G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,3.066,0.001,1KG_EUR_AF,OTOA
387522,16:21705320:A>G,NM_144672.3:c.739+2312A>G,\N,\N,8/27,Benign,\N,intron_variant,1.762,0.9672,1KG_EUR_AF,OTOA
387523,16:21705347:A>G,NM_144672.3:c.739+2339A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,1.526,0.001,1KG_EAS_AF,OTOA
387524,16:21705395:G>A,NM_144672.3:c.739+2387G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.679,0.0014,1KG_AMR_AF,OTOA
387525,16:21705469:G>T,NM_144672.3:c.739+2461G>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.213,\N,\N,OTOA
387526,16:21705470:G>A,NM_144672.3:c.739+2462G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.778,0.001,1KG_EAS_AF|1KG_EUR_AF,OTOA
387527,16:21705485:G>A,NM_144672.3:c.739+2477G>A,\N,\N,8/27,Benign,\N,intron_variant,2.67,0.0537,1KG_AFR_AF,OTOA
387528,16:21705559:C>G,NM_144672.3:c.739+2551C>G,\N,\N,8/27,Unknown significance,\N,intron_variant,0.255,\N,\N,OTOA
387529,16:21705607:T>G,NM_144672.3:c.739+2599T>G,\N,\N,8/27,Unknown significance,\N,intron_variant,0.003,\N,\N,OTOA
387530,16:21705610:A>T,NM_144672.3:c.739+2602A>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.107,0.001,1KG_EAS_AF,OTOA
387531,16:21705620:C>T,NM_144672.3:c.739+2612C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.065,\N,\N,OTOA
387532,16:21705666:G>C,NM_144672.3:c.739+2658G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,0.434,0.002,1KG_EUR_AF,OTOA
387533,16:21705667:G>C,NM_144672.3:c.739+2659G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,0.374,0.001,1KG_SAS_AF,OTOA
387534,16:21705667:G>T,NM_144672.3:c.739+2659G>T,\N,\N,8/27,Benign,\N,intron_variant,0.661,0.0461,1KG_AFR_AF,OTOA
387535,16:21705668:G>C,NM_144672.3:c.739+2660G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,0.005,0.003,1KG_EAS_AF,OTOA
387536,16:21705668:G>T,NM_144672.3:c.739+2660G>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.009,\N,\N,OTOA
387537,16:21705693:G>A,NM_144672.3:c.739+2685G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,2.683,\N,\N,OTOA
387538,16:21705751:G>A,NM_144672.3:c.739+2743G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.002,0.001,1KG_EAS_AF,OTOA
387539,16:21705755:C>T,NM_144672.3:c.739+2747C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,2.757,0.0014,1KG_AMR_AF,OTOA
387540,16:21705837:T>A,NM_144672.3:c.739+2829T>A,\N,\N,8/27,Benign,\N,intron_variant,5.587,0.4274,1KG_EUR_AF,OTOA
387541,16:21705846:C>T,NM_144672.3:c.739+2838C>T,\N,\N,8/27,Benign,\N,intron_variant,6.902,0.0575,1KG_EAS_AF,OTOA
387542,16:21705894:C>T,NM_144672.3:c.739+2886C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,4.278,\N,\N,OTOA
387543,16:21705916:A>G,NM_144672.3:c.739+2908A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,4.077,0.001,1KG_SAS_AF,OTOA
387544,16:21705950:C>T,NM_144672.3:c.739+2942C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,1.016,0.0008,1KG_AFR_AF,OTOA
387545,16:21705951:G>A,NM_144672.3:c.739+2943G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,2.276,\N,\N,OTOA
387546,16:21705951:G>C,NM_144672.3:c.739+2943G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,0.266,0.0015,1KG_AFR_AF,OTOA
387547,16:21706012:T>C,NM_144672.3:c.739+3004T>C,\N,\N,8/27,Benign,\N,intron_variant,9.496,0.9672,1KG_EUR_AF,OTOA
387548,16:21706024:C>T,NM_144672.3:c.739+3016C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.235,\N,\N,OTOA
387549,16:21706039:A>G,NM_144672.3:c.739+3031A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,2.8,0.004,1KG_EUR_AF,OTOA
387550,16:21706061:G>A,NM_144672.3:c.740-3035G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,4.997,0.0008,1KG_AFR_AF,OTOA
387551,16:21706125:A>C,NM_144672.3:c.740-2971A>C,\N,\N,8/27,Unknown significance,\N,intron_variant,11.33,\N,\N,OTOA
387552,16:21706142:T>A,NM_144672.3:c.740-2954T>A,\N,\N,8/27,Unknown significance,\N,intron_variant,8.744,\N,\N,OTOA
387553,16:21706177:C>G,NM_144672.3:c.740-2919C>G,\N,\N,8/27,Unknown significance,\N,intron_variant,16.32,0.0008,1KG_AFR_AF,OTOA
387554,16:21706177:C>T,NM_144672.3:c.740-2919C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,16.97,\N,\N,OTOA
387555,16:21706258:T>C,NM_144672.3:c.740-2838T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,7.613,\N,\N,OTOA
387556,16:21706283:G>C,NM_144672.3:c.740-2813G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,16.78,\N,\N,OTOA
387557,16:21706313:C>T,NM_144672.3:c.740-2783C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,1.481,0.001,1KG_EAS_AF,OTOA
387558,16:21706314:G>A,NM_144672.3:c.740-2782G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,4.282,\N,\N,OTOA
387559,16:21706353:TTC>T,NM_144672.3:c.740-2741_740-2740del,\N,\N,8/27,Benign,\N,intron_variant,3.098,0.3464,1KG_AFR_AF,OTOA
387560,16:21706452:C>A,NM_144672.3:c.740-2644C>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.054,0.0014,1KG_AMR_AF,OTOA
387561,16:21706452:C>T,NM_144672.3:c.740-2644C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.054,\N,\N,OTOA
387562,16:21706453:G>A,NM_144672.3:c.740-2643G>A,\N,\N,8/27,Benign,\N,intron_variant,1.056,0.0113,1KG_AFR_AF,OTOA
387563,16:21706458:C>T,NM_144672.3:c.740-2638C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.313,\N,\N,OTOA
387564,16:21706502:C>T,NM_144672.3:c.740-2594C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,8.776,0.001,1KG_SAS_AF,OTOA
387565,16:21706544:GA>G,NM_144672.3:c.740-2551del,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387566,16:21706544:GAC>G,NM_144672.3:c.740-2551_740-2550del,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387567,16:21706545:A>AC,NM_144672.3:c.740-2539dup,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387568,16:21706545:AC>A,NM_144672.3:c.740-2539del,\N,\N,8/27,Benign,\N,intron_variant,0.959,0.4479,1KG_SAS_AF,OTOA
387569,16:21706545:ACC>A,NM_144672.3:c.740-2540_740-2539del,\N,\N,8/27,Unknown significance,\N,intron_variant,2.5,\N,\N,OTOA
387570,16:21706545:ACCC>A,NM_144672.3:c.740-2541_740-2539del,\N,\N,8/27,Unknown significance,\N,intron_variant,2.596,\N,\N,OTOA
387571,16:21706551:C>CA,NM_144672.3:c.740-2545_740-2544insA,\N,\N,8/27,Unknown significance,\N,intron_variant,2.435,0.0038,1KG_AFR_AF,OTOA
387572,16:21706552:C>G,NM_144672.3:c.740-2544C>G,\N,\N,8/27,Benign,\N,intron_variant,1.292,0.0333,1KG_AFR_AF,OTOA
387573,16:21706553:C>G,NM_144672.3:c.740-2543C>G,\N,\N,8/27,Benign,\N,intron_variant,1.092,0.005,1KG_EAS_AF,OTOA
387574,16:21706554:C>G,NM_144672.3:c.740-2542C>G,\N,\N,8/27,Unknown significance,\N,intron_variant,1.145,0.001,1KG_EUR_AF,OTOA
387575,16:21706554:CC>G,NM_144672.3:c.740-2542_740-2541delinsG,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387576,16:21706555:C>G,NM_144672.3:c.740-2541C>G,\N,\N,8/27,Benign,\N,intron_variant,1.016,0.0507,1KG_AFR_AF,OTOA
387577,16:21706557:C>A,NM_144672.3:c.740-2539C>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.803,\N,\N,OTOA
387578,16:21706558:A>T,NM_144672.3:c.740-2538A>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.279,\N,\N,OTOA
387579,16:21706642:G>A,NM_144672.3:c.740-2454G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,2.439,\N,\N,OTOA
387580,16:21706667:A>G,NM_144672.3:c.740-2429A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,5.241,\N,\N,OTOA
387581,16:21706671:C>T,NM_144672.3:c.740-2425C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,5.72,\N,\N,OTOA
387582,16:21706680:C>T,NM_144672.3:c.740-2416C>T,\N,\N,8/27,Benign,\N,intron_variant,5.83,0.0477,1KG_AFR_AF,OTOA
387583,16:21706696:G>A,NM_144672.3:c.740-2400G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.235,\N,\N,OTOA
387584,16:21706696:GA>G,NM_144672.3:c.740-2389del,\N,\N,8/27,Unknown significance,\N,intron_variant,0.237,\N,\N,OTOA
387585,16:21706697:A>G,NM_144672.3:c.740-2399A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,0.756,\N,\N,OTOA
387586,16:21706714:G>T,NM_144672.3:c.740-2382G>T,\N,\N,8/27,Benign,\N,intron_variant,6.19,0.0113,1KG_AFR_AF,OTOA
387587,16:21706726:T>C,NM_144672.3:c.740-2370T>C,\N,\N,8/27,Benign,\N,intron_variant,1.083,0.007,1KG_EUR_AF,OTOA
387588,16:21706749:T>A,NM_144672.3:c.740-2347T>A,\N,\N,8/27,Unknown significance,\N,intron_variant,5.193,\N,\N,OTOA
387589,16:21706779:T>A,NM_144672.3:c.740-2317T>A,\N,\N,8/27,Unknown significance,\N,intron_variant,5.871,\N,\N,OTOA
387590,16:21706805:G>T,NM_144672.3:c.740-2291G>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.139,\N,\N,OTOA
387591,16:21706837:T>C,NM_144672.3:c.740-2259T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,1.484,0.003,1KG_EUR_AF,OTOA
387592,16:21706873:A>T,NM_144672.3:c.740-2223A>T,\N,\N,8/27,Benign,\N,intron_variant,2.056,0.0585,1KG_EAS_AF,OTOA
387593,16:21706915:T>TG,NM_144672.3:c.740-2179dup,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387594,16:21706935:A>G,NM_144672.3:c.740-2161A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,1.161,\N,\N,OTOA
387595,16:21706956:T>C,NM_144672.3:c.740-2140T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,3.366,0.0015,1KG_AFR_AF,OTOA
387596,16:21707029:G>A,NM_144672.3:c.740-2067G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,3.769,\N,\N,OTOA
387597,16:21707036:T>G,NM_144672.3:c.740-2060T>G,\N,\N,8/27,Unknown significance,\N,intron_variant,5.449,0.001,1KG_EAS_AF,OTOA
387598,16:21707187:G>GATAT,NM_144672.3:c.740-1886_740-1883dup,\N,\N,8/27,Unknown significance,\N,intron_variant,0.08,\N,\N,OTOA
387599,16:21707187:GATAT>G,NM_144672.3:c.740-1886_740-1883del,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387600,16:21707210:A>T,NM_144672.3:c.740-1886A>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.168,\N,\N,OTOA
387601,16:21707212:A>ATT,NM_144672.3:c.740-1866_740-1865dup,\N,\N,8/27,Benign,\N,intron_variant,0.03,0.5169,1KG_EUR_AF,OTOA
387602,16:21707212:A>T,NM_144672.3:c.740-1884A>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.015,\N,\N,OTOA
387603,16:21707213:T>TATATA,NM_144672.3:c.740-1883_740-1882insATATA,\N,\N,8/27,Unknown significance,\N,intron_variant,0.147,\N,\N,OTOA
387604,16:21707213:T>TATATATATATA,NM_144672.3:c.740-1883_740-1882insATATATATATA,\N,\N,8/27,Unknown significance,\N,intron_variant,0.086,\N,\N,OTOA
387605,16:21707236:G>A,NM_144672.3:c.740-1860G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.886,\N,\N,OTOA
387606,16:21707240:G>A,NM_144672.3:c.740-1856G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.279,0.001,1KG_EAS_AF,OTOA
387607,16:21707276:T>C,NM_144672.3:c.740-1820T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,0.168,\N,\N,OTOA
387608,16:21707282:C>T,NM_144672.3:c.740-1814C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,4.391,0.0008,1KG_AFR_AF,OTOA
387609,16:21707284:C>T,NM_144672.3:c.740-1812C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,4.731,0.0008,1KG_AFR_AF,OTOA
387610,16:21707285:A>G,NM_144672.3:c.740-1811A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,4.403,0.0008,1KG_AFR_AF,OTOA
387611,16:21707436:G>A,NM_144672.3:c.740-1660G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.069,\N,\N,OTOA
387612,16:21707466:G>A,NM_144672.3:c.740-1630G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.892,\N,\N,OTOA
387613,16:21707477:G>A,NM_144672.3:c.740-1619G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,4.803,0.001,1KG_SAS_AF,OTOA
387614,16:21707608:T>C,NM_144672.3:c.740-1488T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,5.065,\N,\N,OTOA
387615,16:21707628:C>T,NM_144672.3:c.740-1468C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,1.227,0.0014,1KG_AMR_AF,OTOA
387616,16:21707656:G>A,NM_144672.3:c.740-1440G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,3.613,0.002,1KG_EAS_AF,OTOA
387617,16:21707662:G>A,NM_144672.3:c.740-1434G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,1.821,\N,\N,OTOA
387618,16:21707678:T>A,NM_144672.3:c.740-1418T>A,\N,\N,8/27,Unknown significance,\N,intron_variant,8.027,0.002,1KG_EAS_AF,OTOA
387619,16:21707690:A>G,NM_144672.3:c.740-1406A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,5.741,0.0008,1KG_AFR_AF,OTOA
387620,16:21707720:T>C,NM_144672.3:c.740-1376T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,7.813,0.001,1KG_SAS_AF,OTOA
387621,16:21707737:G>A,NM_144672.3:c.740-1359G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,2.74,0.0014,1KG_AMR_AF,OTOA
387622,16:21707743:G>A,NM_144672.3:c.740-1353G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,6.474,0.001,1KG_SAS_AF,OTOA
387623,16:21707745:C>A,NM_144672.3:c.740-1351C>A,\N,\N,8/27,Unknown significance,\N,intron_variant,6.769,\N,\N,OTOA
387624,16:21707747:A>G,NM_144672.3:c.740-1349A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,6.663,\N,\N,OTOA
387625,16:21707759:G>C,NM_144672.3:c.740-1337G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,1.314,\N,\N,OTOA
387626,16:21707882:C>T,NM_144672.3:c.740-1214C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,5.464,\N,\N,OTOA
387627,16:21707902:T>C,NM_144672.3:c.740-1194T>C,\N,\N,8/27,Benign,\N,intron_variant,8.279,0.006,1KG_EAS_AF,OTOA
387628,16:21707905:T>C,NM_144672.3:c.740-1191T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,7.739,\N,\N,OTOA
387629,16:21707959:C>T,NM_144672.3:c.740-1137C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,1.508,\N,\N,OTOA
387630,16:21707960:G>A,NM_144672.3:c.740-1136G>A,\N,\N,8/27,Benign,\N,intron_variant,3.155,0.0419,1KG_SAS_AF,OTOA
387631,16:21708076:G>A,NM_144672.3:c.740-1020G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,2.886,\N,\N,OTOA
387632,16:21708097:C>G,NM_144672.3:c.740-999C>G,\N,\N,8/27,Unknown significance,\N,intron_variant,0.048,\N,\N,OTOA
387633,16:21708112:G>GT,NM_144672.3:c.740-981dup,\N,\N,8/27,Unknown significance,\N,intron_variant,0.479,0.0041,1KG_SAS_AF,OTOA
387634,16:21708115:T>TC,NM_144672.3:c.740-979dup,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387635,16:21708131:A>G,NM_144672.3:c.740-965A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,7.303,\N,\N,OTOA
387636,16:21708137:C>T,NM_144672.3:c.740-959C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,1.238,0.0008,1KG_AFR_AF,OTOA
387637,16:21708179:A>G,NM_144672.3:c.740-917A>G,\N,\N,8/27,Benign,\N,intron_variant,6.845,0.0446,1KG_AFR_AF,OTOA
387638,16:21708246:G>T,NM_144672.3:c.740-850G>T,\N,\N,8/27,Unknown significance,\N,intron_variant,6.614,\N,\N,OTOA
387639,16:21708276:G>GACATAGCTCAC,NM_144672.3:c.740-820_740-819insACATAGCTCAC,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387640,16:21708285:G>A,NM_144672.3:c.740-811G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,3.224,\N,\N,OTOA
387641,16:21708285:G>GCACATAGCTCA,NM_144672.3:c.740-810_740-809insACATAGCTCAC,\N,\N,8/27,Benign,\N,intron_variant,0.633,0.9894,1KG_AFR_AF,OTOA
387642,16:21708347:A>T,NM_144672.3:c.740-749A>T,\N,\N,8/27,Unknown significance,\N,intron_variant,5.371,0.001,1KG_EAS_AF,OTOA
387643,16:21708358:C>CT,NM_144672.3:c.740-714dup,\N,\N,8/27,Unknown significance,\N,intron_variant,8.665,\N,\N,OTOA
387644,16:21708358:C>CTT,NM_144672.3:c.740-715_740-714dup,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387645,16:21708358:CTTTTTTTTTTT>C,NM_144672.3:c.740-724_740-714del,\N,\N,8/27,Benign,\N,intron_variant,10.04,0.7306,1KG_EUR_AF,OTOA
387646,16:21708387:C>T,NM_144672.3:c.740-709C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.948,\N,\N,OTOA
387647,16:21708464:A>C,NM_144672.3:c.740-632A>C,\N,\N,8/27,Unknown significance,\N,intron_variant,4.505,\N,\N,OTOA
387648,16:21708479:A>G,NM_144672.3:c.740-617A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,1.999,\N,\N,OTOA
387649,16:21708488:G>A,NM_144672.3:c.740-608G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,8.673,0.001,1KG_EUR_AF,OTOA
387650,16:21708514:A>G,NM_144672.3:c.740-582A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,5.769,0.0015,1KG_AFR_AF,OTOA
387651,16:21708522:C>T,NM_144672.3:c.740-574C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,3.337,\N,\N,OTOA
387652,16:21708682:G>T,NM_144672.3:c.740-414G>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.442,0.002,1KG_EAS_AF,OTOA
387653,16:21708708:T>A,NM_144672.3:c.740-388T>A,\N,\N,8/27,Unknown significance,\N,intron_variant,10.25,0.0014,1KG_AMR_AF,OTOA
387654,16:21708709:T>C,NM_144672.3:c.740-387T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,7.838,0.001,1KG_EAS_AF,OTOA
387655,16:21708763:G>T,NM_144672.3:c.740-333G>T,\N,\N,8/27,Unknown significance,\N,intron_variant,1.508,\N,\N,OTOA
387656,16:21708769:C>G,NM_144672.3:c.740-327C>G,\N,\N,8/27,Unknown significance,\N,intron_variant,3.1,0.001,1KG_SAS_AF,OTOA
387657,16:21708777:A>T,NM_144672.3:c.740-319A>T,\N,\N,8/27,Unknown significance,\N,intron_variant,3.112,0.001,1KG_EAS_AF,OTOA
387658,16:21708808:G>A,NM_144672.3:c.740-288G>A,\N,\N,8/27,Benign,\N,intron_variant,2.664,0.0787,1KG_AFR_AF,OTOA
387659,16:21708808:GC>AT,NM_144672.3:c.740-288_740-287delinsAT,\N,\N,8/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387660,16:21708809:C>T,NM_144672.3:c.740-287C>T,\N,\N,8/27,Benign,\N,intron_variant,0.855,0.0787,1KG_AFR_AF,OTOA
387661,16:21708823:G>A,NM_144672.3:c.740-273G>A,\N,\N,8/27,Benign,\N,intron_variant,1.579,0.005,1KG_EAS_AF,OTOA
387662,16:21708827:G>T,NM_144672.3:c.740-269G>T,\N,\N,8/27,Unknown significance,\N,intron_variant,2.105,\N,\N,OTOA
387663,16:21708877:C>G,NM_144672.3:c.740-219C>G,\N,\N,8/27,Unknown significance,\N,intron_variant,0.403,\N,\N,OTOA
387664,16:21708877:C>T,NM_144672.3:c.740-219C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,0.712,\N,\N,OTOA
387665,16:21708878:G>A,NM_144672.3:c.740-218G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.855,\N,\N,OTOA
387666,16:21708885:G>A,NM_144672.3:c.740-211G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.994,\N,\N,OTOA
387667,16:21708939:T>C,NM_144672.3:c.740-157T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,3.671,\N,\N,OTOA
387668,16:21708951:T>G,NM_144672.3:c.740-145T>G,\N,\N,8/27,Benign,\N,intron_variant,6.582,0.0099,1KG_EAS_AF,OTOA
387669,16:21708963:G>A,NM_144672.3:c.740-133G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.245,\N,\N,OTOA
387670,16:21708978:G>A,NM_144672.3:c.740-118G>A,\N,\N,8/27,Benign,\N,intron_variant,7.429,0.0092,1KG_SAS_AF,OTOA
387671,16:21709014:A>G,NM_144672.3:c.740-82A>G,\N,\N,8/27,Unknown significance,\N,intron_variant,5.343,0.0008,1KG_AFR_AF,OTOA
387672,16:21709020:T>C,NM_144672.3:c.740-76T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,10.55,0.0008,1KG_AFR_AF,OTOA
387673,16:21709021:G>A,NM_144672.3:c.740-75G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,10.46,0.001,1KG_SAS_AF,OTOA
387674,16:21709047:G>C,NM_144672.3:c.740-49G>C,\N,\N,8/27,Unknown significance,\N,intron_variant,1.545,0.0000151616,EXAC_NFE_AF,OTOA
387675,16:21709053:A>T,NM_144672.3:c.740-43A>T,\N,\N,8/27,Benign,\N,intron_variant,4.918,0.00576369,EXAC_EAS_AF,OTOA
387676,16:21709058:T>C,NM_144672.3:c.740-38T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,2.811,0.00001514,EXAC_NFE_AF,OTOA
387677,16:21709061:A>T,NM_144672.3:c.740-35A>T,\N,\N,8/27,Unknown significance,\N,intron_variant,2.02,0.00001513,EXAC_NFE_AF,OTOA
387678,16:21709063:G>A,NM_144672.3:c.740-33G>A,\N,\N,8/27,Unknown significance,\N,intron_variant,0.424,0.001,1KG_EAS_AF,OTOA
387679,16:21709068:C>T,NM_144672.3:c.740-28C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,2.559,0.000135857,EXAC_NFE_AF,OTOA
387680,16:21709076:C>T,NM_144672.3:c.740-20C>T,\N,\N,8/27,Unknown significance,\N,intron_variant,4.938,0.000348837,EVS_EA_AF,OTOA
387681,16:21709083:T>A,NM_144672.3:c.740-13T>A,\N,\N,8/27,Unknown significance,\N,intron_variant,7.69,0.000227376,EVS_AA_AF,OTOA
387682,16:21709084:T>C,NM_144672.3:c.740-12T>C,\N,\N,8/27,Unknown significance,\N,intron_variant,4.903,0.002,1KG_SAS_AF,OTOA
387683,16:21709085:A>AT,NM_144672.3:c.740-5dup,\N,\N,8/27,Unknown significance,\N,intron_variant,5.589,0.000466853,EXAC_EAS_AF,OTOA
387684,16:21709091:T>A,NM_144672.3:c.740-5T>A,\N,\N,8/27,Unknown significance,\N,splice_region_variant&intron_variant,13.55,0.000698812,EXAC_EAS_AF,OTOA
387685,16:21709092:G>A,NM_144672.3:c.740-4G>A,\N,\N,8/27,Unknown significance,\N,splice_region_variant&intron_variant,14,0.000682128,EVS_AA_AF,OTOA
387686,16:21709099:ACTCTG>A,NM_144672.3:c.746_750del,NP_653273.3:p.Ser249PhefsTer21,9/28,\N,Unknown significance,\N,frameshift_variant,35,\N,\N,OTOA
387687,16:21709106:T>C,NM_144672.3:c.750T>C,NP_653273.3:p.Ala250=,9/28,\N,Unknown significance,\N,synonymous_variant,4.024,0.0000606134,EXAC_SAS_AF,OTOA
387688,16:21709107:T>A,NM_144672.3:c.751T>A,NP_653273.3:p.Ser251Thr,9/28,\N,Unknown significance,\N,missense_variant,26.9,0.001,1KG_SAS_AF,OTOA
387689,16:21709109:A>G,NM_144672.3:c.753A>G,NP_653273.3:p.Ser251=,9/28,\N,Unknown significance,\N,synonymous_variant,9.096,\N,\N,OTOA
387690,16:21709112:G>A,NM_144672.3:c.756G>A,NP_653273.3:p.Trp252Ter,9/28,\N,Unknown significance,\N,stop_gained,40,0.000014997,EXAC_NFE_AF,OTOA
387691,16:21709117:G>A,NM_144672.3:c.761G>A,NP_653273.3:p.Ser254Asn,9/28,\N,Unknown significance,\N,missense_variant,22.2,0.00011566,EXAC_EAS_AF,OTOA
387692,16:21709120:C>A,NM_144672.3:c.764C>A,NP_653273.3:p.Ala255Glu,9/28,\N,Unknown significance,\N,missense_variant,33,0.000115634,EXAC_EAS_AF,OTOA
387693,16:21709120:C>T,NM_144672.3:c.764C>T,NP_653273.3:p.Ala255Val,9/28,\N,Unknown significance,\N,missense_variant,33,0.000345722,EXAC_AMR_AF,OTOA
387694,16:21709121:G>A,NM_144672.3:c.765G>A,NP_653273.3:p.Ala255=,9/28,\N,Unknown significance,\N,synonymous_variant,13.96,0.000115634,EXAC_EAS_AF,OTOA
387695,16:21709132:G>T,NM_144672.3:c.776G>T,NP_653273.3:p.Trp259Leu,9/28,\N,Unknown significance,\N,missense_variant,25.9,\N,\N,OTOA
387696,16:21709138:T>G,NM_144672.3:c.782T>G,NP_653273.3:p.Leu261Trp,9/28,\N,Unknown significance,\N,missense_variant,26.7,0.000060584,EXAC_SAS_AF,OTOA
387697,16:21709141:G>A,NM_001161683.1:c.548G>A,NP_001155155.1:p.Gly183Asp,5/24,\N,Unknown significance,\N,missense_variant,28.1,0.0000599538,EXAC_NFE_AF,OTOA
387698,16:21709142:C>A,NM_144672.3:c.786C>A,NP_653273.3:p.Gly262=,9/28,\N,Unknown significance,\N,synonymous_variant,14.93,0.0000961354,EXAC_AFR_AF,OTOA
387699,16:21709151:G>T,NM_144672.3:c.795G>T,NP_653273.3:p.Met265Ile,9/28,\N,Unknown significance,\N,missense_variant,17.95,0.000346821,EXAC_EAS_AF,OTOA
387700,16:21709158:C>G,NM_144672.3:c.802C>G,NP_653273.3:p.Leu268Val,9/28,\N,Unknown significance,\N,missense_variant,27,0.0000149867,EXAC_NFE_AF,OTOA
387701,16:21709162:C>A,NM_144672.3:c.806C>A,NP_653273.3:p.Ser269Ter,9/28,\N,Unknown significance,\N,stop_gained,36,0.0014,1KG_AMR_AF,OTOA
387702,16:21709162:C>T,NM_144672.3:c.806C>T,NP_653273.3:p.Ser269Leu,9/28,\N,Unknown significance,\N,missense_variant,29.5,0.000227376,EVS_AA_AF,OTOA
387703,16:21709163:G>A,NM_144672.3:c.807G>A,NP_653273.3:p.Ser269=,9/28,\N,Unknown significance,\N,synonymous_variant,12.24,0.0000605914,EXAC_SAS_AF,OTOA
387704,16:21709171:A>G,NM_144672.3:c.815A>G,NP_653273.3:p.Glu272Gly,9/28,\N,Unknown significance,\N,missense_variant,28,0.0008,1KG_AFR_AF,OTOA
387705,16:21709177:C>T,NM_144672.3:c.821C>T,NP_653273.3:p.Thr274Met,9/28,\N,Likely benign,\N,missense_variant,8.262,0.000348837,EVS_EA_AF,OTOA
387706,16:21709178:G>A,NM_144672.3:c.822G>A,NP_653273.3:p.Thr274=,9/28,\N,Unknown significance,\N,synonymous_variant,12.08,0.0000149894,EXAC_NFE_AF,OTOA
387707,16:21709182:AT>A,NM_144672.3:c.828del,NP_653273.3:p.Ser277ValfsTer3,9/28,\N,Unknown significance,\N,frameshift_variant,35,0.000134933,EXAC_NFE_AF,OTOA
387708,16:21709184:T>G,NM_144672.3:c.828T>G,NP_653273.3:p.Ile276Met,9/28,\N,Unknown significance,\N,missense_variant,24.6,0.000227376,EVS_AA_AF,OTOA
387709,16:21709188:C>T,NM_144672.3:c.832C>T,NP_653273.3:p.Pro278Ser,9/28,\N,Likely benign,\N,missense_variant,17.85,0.000116279,EVS_EA_AF,OTOA
387710,16:21709191:A>G,NM_144672.3:c.835A>G,NP_653273.3:p.Ile279Val,9/28,\N,Likely benign,\N,missense_variant,0.002,0.000121227,EXAC_SAS_AF,OTOA
387711,16:21709197:G>A,NM_144672.3:c.840+1G>A,\N,\N,9/27,Unknown significance,\N,splice_donor_variant,26.2,\N,\N,OTOA
387712,16:21709212:A>T,NM_144672.3:c.840+16A>T,\N,\N,9/27,Unknown significance,\N,intron_variant,3.128,0.0000150295,EXAC_NFE_AF,OTOA
387713,16:21709216:TTA>T,NM_144672.3:c.840+24_840+25del,\N,\N,9/27,Unknown significance,\N,intron_variant,7.859,\N,\N,OTOA
387714,16:21709238:C>A,NM_144672.3:c.840+42C>A,\N,\N,9/27,Unknown significance,\N,intron_variant,3.195,\N,\N,OTOA
387715,16:21709270:T>C,NM_144672.3:c.840+74T>C,\N,\N,9/27,Benign,\N,intron_variant,3.635,0.0129,1KG_EAS_AF,OTOA
387716,16:21709289:G>A,NM_144672.3:c.840+93G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,9.112,\N,\N,OTOA
387717,16:21709310:C>T,NM_144672.3:c.840+114C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,2.801,0.0008,1KG_AFR_AF,OTOA
387718,16:21709320:C>T,NM_144672.3:c.840+124C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,3.964,0.001,1KG_SAS_AF,OTOA
387719,16:21709321:C>A,NM_144672.3:c.840+125C>A,\N,\N,9/27,Unknown significance,\N,intron_variant,3.786,\N,\N,OTOA
387720,16:21709360:A>G,NM_144672.3:c.840+164A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,1.419,0.001,1KG_EUR_AF,OTOA
387721,16:21709388:T>C,NM_144672.3:c.840+192T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,4.876,0.001,1KG_EAS_AF,OTOA
387722,16:21709395:T>C,NM_144672.3:c.840+199T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,2.125,0.0008,1KG_AFR_AF,OTOA
387723,16:21709418:G>T,NM_144672.3:c.840+222G>T,\N,\N,9/27,Unknown significance,\N,intron_variant,1.58,0.003,1KG_EUR_AF,OTOA
387724,16:21709442:T>A,NM_144672.3:c.840+246T>A,\N,\N,9/27,Unknown significance,\N,intron_variant,4.954,\N,\N,OTOA
387725,16:21709486:A>G,NM_144672.3:c.840+290A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,6.058,0.001,1KG_EUR_AF,OTOA
387726,16:21709507:A>G,NM_144672.3:c.840+311A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,8.818,\N,\N,OTOA
387727,16:21709525:G>A,NM_144672.3:c.840+329G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,9.289,\N,\N,OTOA
387728,16:21709540:T>C,NM_144672.3:c.840+344T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,1.696,0.001,1KG_EAS_AF,OTOA
387729,16:21709603:T>C,NM_144672.3:c.840+407T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,6.094,0.001,1KG_EAS_AF,OTOA
387730,16:21709631:C>T,NM_144672.3:c.840+435C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,7.655,0.001,1KG_EAS_AF,OTOA
387731,16:21709672:T>A,NM_144672.3:c.840+476T>A,\N,\N,9/27,Unknown significance,\N,intron_variant,11.06,0.0041,1KG_SAS_AF,OTOA
387732,16:21709701:A>G,NM_144672.3:c.840+505A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,2.655,0.001,1KG_SAS_AF,OTOA
387733,16:21709701:A>T,NM_144672.3:c.840+505A>T,\N,\N,9/27,Unknown significance,\N,intron_variant,1.354,\N,\N,OTOA
387734,16:21709710:C>T,NM_144672.3:c.840+514C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,2.155,0.002,1KG_SAS_AF,OTOA
387735,16:21709758:T>A,NM_144672.3:c.840+562T>A,\N,\N,9/27,Unknown significance,\N,intron_variant,14.54,0.002,1KG_SAS_AF,OTOA
387736,16:21709764:C>T,NM_144672.3:c.840+568C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,13.58,0.002,1KG_SAS_AF,OTOA
387737,16:21709777:T>C,NM_144672.3:c.840+581T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,13.28,0.001,1KG_EAS_AF,OTOA
387738,16:21709783:T>TTGAA,NM_144672.3:c.840+590_840+593dup,\N,\N,9/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387739,16:21709786:A>C,NM_144672.3:c.840+590A>C,\N,\N,9/27,Unknown significance,\N,intron_variant,6.553,\N,\N,OTOA
387740,16:21709790:C>T,NM_144672.3:c.840+594C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,1.721,\N,\N,OTOA
387741,16:21709792:G>A,NM_144672.3:c.840+596G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,3.958,\N,\N,OTOA
387742,16:21709812:A>G,NM_144672.3:c.840+616A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,3.5,0.0008,1KG_AFR_AF,OTOA
387743,16:21709853:A>T,NM_144672.3:c.840+657A>T,\N,\N,9/27,Unknown significance,\N,intron_variant,3.505,\N,\N,OTOA
387744,16:21709856:T>TTTC,NM_144672.3:c.840+678_840+680dup,\N,\N,9/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387745,16:21709856:TTTC>T,NM_144672.3:c.840+678_840+680del,\N,\N,9/27,Unknown significance,\N,intron_variant,2.987,\N,\N,OTOA
387746,16:21709859:C>A,NM_144672.3:c.840+663C>A,\N,\N,9/27,Unknown significance,\N,intron_variant,0.856,0.0014,1KG_AMR_AF,OTOA
387747,16:21709922:G>A,NM_144672.3:c.840+726G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,6.575,0.001,1KG_EUR_AF,OTOA
387748,16:21709954:C>T,NM_144672.3:c.840+758C>T,\N,\N,9/27,Benign,\N,intron_variant,4.431,0.006,1KG_EAS_AF,OTOA
387749,16:21709998:A>G,NM_144672.3:c.840+802A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,4.752,\N,\N,OTOA
387750,16:21710002:G>A,NM_144672.3:c.840+806G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,2.274,0.0008,1KG_AFR_AF,OTOA
387751,16:21710084:G>A,NM_144672.3:c.840+888G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,2.482,0.0014,1KG_AMR_AF,OTOA
387752,16:21710087:C>A,NM_144672.3:c.840+891C>A,\N,\N,9/27,Unknown significance,\N,intron_variant,6.319,0.0008,1KG_AFR_AF,OTOA
387753,16:21710152:A>C,NM_144672.3:c.840+956A>C,\N,\N,9/27,Unknown significance,\N,intron_variant,1.608,\N,\N,OTOA
387754,16:21710189:A>G,NM_144672.3:c.840+993A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,2.818,\N,\N,OTOA
387755,16:21710203:T>C,NM_144672.3:c.840+1007T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,3.089,0.001,1KG_SAS_AF,OTOA
387756,16:21710227:A>G,NM_144672.3:c.840+1031A>G,\N,\N,9/27,Benign,\N,intron_variant,12.76,0.0129,1KG_EUR_AF,OTOA
387757,16:21710250:G>A,NM_144672.3:c.840+1054G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,1.557,0.0008,1KG_AFR_AF,OTOA
387758,16:21710257:G>C,NM_144672.3:c.840+1061G>C,\N,\N,9/27,Benign,\N,intron_variant,0.387,0.0058,1KG_AMR_AF,OTOA
387759,16:21710260:A>AATTTT,NM_144672.3:c.840+1079_840+1083dup,\N,\N,9/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387760,16:21710260:A>T,NM_144672.3:c.840+1064A>T,\N,\N,9/27,Unknown significance,\N,intron_variant,1.995,0.0041,1KG_SAS_AF,OTOA
387761,16:21710294:T>C,NM_144672.3:c.840+1098T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,0.064,0.003,1KG_AFR_AF,OTOA
387762,16:21710302:C>T,NM_144672.3:c.840+1106C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,2.884,\N,\N,OTOA
387763,16:21710305:T>G,NM_144672.3:c.840+1109T>G,\N,\N,9/27,Unknown significance,\N,intron_variant,3.398,0.0014,1KG_AMR_AF,OTOA
387764,16:21710307:T>C,NM_144672.3:c.840+1111T>C,\N,\N,9/27,Benign,\N,intron_variant,1.491,0.2625,1KG_AFR_AF,OTOA
387765,16:21710308:G>A,NM_144672.3:c.840+1112G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,1.124,0.0023,1KG_AFR_AF,OTOA
387766,16:21710311:G>A,NM_144672.3:c.840+1115G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,0.056,0.0014,1KG_AMR_AF,OTOA
387767,16:21710314:C>G,NM_144672.3:c.840+1118C>G,\N,\N,9/27,Unknown significance,\N,intron_variant,0.451,0.001,1KG_SAS_AF,OTOA
387768,16:21710343:C>T,NM_144672.3:c.840+1147C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,2.212,\N,\N,OTOA
387769,16:21710376:A>T,NM_144672.3:c.840+1180A>T,\N,\N,9/27,Unknown significance,\N,intron_variant,7.346,0.0008,1KG_AFR_AF,OTOA
387770,16:21710415:G>A,NM_144672.3:c.840+1219G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,2.946,\N,\N,OTOA
387771,16:21710460:C>T,NM_144672.3:c.840+1264C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,0.892,\N,\N,OTOA
387772,16:21710464:G>A,NM_144672.3:c.840+1268G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,3.619,0.003,1KG_EUR_AF,OTOA
387773,16:21710469:A>G,NM_144672.3:c.840+1273A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,3.637,\N,\N,OTOA
387774,16:21710489:C>T,NM_144672.3:c.840+1293C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,2.533,0.0008,1KG_AFR_AF,OTOA
387775,16:21710490:T>C,NM_144672.3:c.840+1294T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,1.808,\N,\N,OTOA
387776,16:21710526:G>A,NM_144672.3:c.840+1330G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,5.404,0.001,1KG_EAS_AF,OTOA
387777,16:21710562:C>G,NM_144672.3:c.840+1366C>G,\N,\N,9/27,Unknown significance,\N,intron_variant,1.524,\N,\N,OTOA
387778,16:21710562:C>T,NM_144672.3:c.840+1366C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,2.518,0.0015,1KG_AFR_AF,OTOA
387779,16:21710590:T>C,NM_144672.3:c.840+1394T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,1.123,\N,\N,OTOA
387780,16:21710591:G>A,NM_144672.3:c.840+1395G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,1.256,0.0008,1KG_AFR_AF,OTOA
387781,16:21710604:G>A,NM_144672.3:c.840+1408G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,2.361,0.001,1KG_SAS_AF,OTOA
387782,16:21710649:A>G,NM_144672.3:c.840+1453A>G,\N,\N,9/27,Benign,\N,intron_variant,1.91,0.1142,1KG_AFR_AF,OTOA
387783,16:21710668:T>C,NM_144672.3:c.840+1472T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,2.923,0.0008,1KG_AFR_AF,OTOA
387784,16:21710678:C>T,NM_144672.3:c.840+1482C>T,\N,\N,9/27,Benign,\N,intron_variant,0.506,0.2632,1KG_AFR_AF,OTOA
387785,16:21710679:G>A,NM_144672.3:c.840+1483G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,0.459,0.0008,1KG_AFR_AF,OTOA
387786,16:21710685:C>T,NM_144672.3:c.840+1489C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,0.524,0.001,1KG_EAS_AF,OTOA
387787,16:21710727:C>T,NM_144672.3:c.841-1482C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,0.284,0.003,1KG_EAS_AF,OTOA
387788,16:21710732:G>C,NM_144672.3:c.841-1477G>C,\N,\N,9/27,Unknown significance,\N,intron_variant,0.35,\N,\N,OTOA
387789,16:21710842:C>T,NM_144672.3:c.841-1367C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,2.301,0.001,1KG_EUR_AF,OTOA
387790,16:21710891:G>A,NM_144672.3:c.841-1318G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,3.995,\N,\N,OTOA
387791,16:21710901:T>G,NM_144672.3:c.841-1308T>G,\N,\N,9/27,Unknown significance,\N,intron_variant,4.87,0.0045,1KG_AFR_AF,OTOA
387792,16:21710942:AGT>A,NM_144672.3:c.841-1265_841-1264del,\N,\N,9/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387793,16:21710978:G>A,NM_144672.3:c.841-1231G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,1.209,0.001,1KG_EUR_AF,OTOA
387794,16:21711011:G>A,NM_144672.3:c.841-1198G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,0.785,0.001,1KG_EAS_AF,OTOA
387795,16:21711027:G>A,NM_144672.3:c.841-1182G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,1.221,0.0008,1KG_AFR_AF,OTOA
387796,16:21711069:G>A,NM_144672.3:c.841-1140G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,1.85,0.001,1KG_EAS_AF,OTOA
387797,16:21711076:C>G,NM_144672.3:c.841-1133C>G,\N,\N,9/27,Unknown significance,\N,intron_variant,2.757,\N,\N,OTOA
387798,16:21711088:A>T,NM_144672.3:c.841-1121A>T,\N,\N,9/27,Benign,\N,intron_variant,0.898,0.7167,1KG_EUR_AF,OTOA
387799,16:21711096:C>T,NM_144672.3:c.841-1113C>T,\N,\N,9/27,Benign,\N,intron_variant,0.116,0.7167,1KG_EUR_AF,OTOA
387800,16:21711139:C>T,NM_144672.3:c.841-1070C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,9.251,0.001,1KG_EAS_AF,OTOA
387801,16:21711142:A>G,NM_144672.3:c.841-1067A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,6.311,0.0015,1KG_AFR_AF,OTOA
387802,16:21711150:G>A,NM_144672.3:c.841-1059G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,4.873,\N,\N,OTOA
387803,16:21711153:T>A,NM_144672.3:c.841-1056T>A,\N,\N,9/27,Unknown significance,\N,intron_variant,8.258,0.002,1KG_SAS_AF,OTOA
387804,16:21711303:C>A,NM_144672.3:c.841-906C>A,\N,\N,9/27,Unknown significance,\N,intron_variant,0.387,0.001,1KG_EUR_AF,OTOA
387805,16:21711354:T>C,NM_144672.3:c.841-855T>C,\N,\N,9/27,Benign,\N,intron_variant,1.079,0.0113,1KG_AFR_AF,OTOA
387806,16:21711405:G>A,NM_144672.3:c.841-804G>A,\N,\N,9/27,Benign,\N,intron_variant,4.772,0.0058,1KG_AMR_AF,OTOA
387807,16:21711417:A>G,NM_144672.3:c.841-792A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,3.106,0.0023,1KG_AFR_AF,OTOA
387808,16:21711487:G>A,NM_144672.3:c.841-722G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,4.572,\N,\N,OTOA
387809,16:21711507:A>G,NM_144672.3:c.841-702A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,6.442,0.001,1KG_SAS_AF,OTOA
387810,16:21711525:C>T,NM_144672.3:c.841-684C>T,\N,\N,9/27,Benign,\N,intron_variant,5.706,0.0164,1KG_SAS_AF,OTOA
387811,16:21711585:G>T,NM_144672.3:c.841-624G>T,\N,\N,9/27,Unknown significance,\N,intron_variant,9.197,\N,\N,OTOA
387812,16:21711632:A>G,NM_144672.3:c.841-577A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,14.94,0.0014,1KG_AMR_AF,OTOA
387813,16:21711646:A>G,NM_144672.3:c.841-563A>G,\N,\N,9/27,Benign,\N,intron_variant,13.93,0.0061,1KG_AFR_AF,OTOA
387814,16:21711648:C>T,NM_144672.3:c.841-561C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,13.8,\N,\N,OTOA
387815,16:21711754:A>G,NM_144672.3:c.841-455A>G,\N,\N,9/27,Unknown significance,\N,intron_variant,1.154,0.003,1KG_AFR_AF,OTOA
387816,16:21711755:T>C,NM_144672.3:c.841-454T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,1.498,0.001,1KG_SAS_AF,OTOA
387817,16:21711781:T>C,NM_144672.3:c.841-428T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,2.419,0.001,1KG_SAS_AF,OTOA
387818,16:21711795:C>T,NM_144672.3:c.841-414C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,1.815,\N,\N,OTOA
387819,16:21711816:C>T,NM_144672.3:c.841-393C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,0.205,0.0029,1KG_AMR_AF,OTOA
387820,16:21711827:C>G,NM_144672.3:c.841-382C>G,\N,\N,9/27,Unknown significance,\N,intron_variant,0.614,\N,\N,OTOA
387821,16:21711851:G>C,NM_144672.3:c.841-358G>C,\N,\N,9/27,Benign,\N,intron_variant,0.977,0.7194,1KG_AFR_AF,OTOA
387822,16:21711932:G>T,NM_144672.3:c.841-277G>T,\N,\N,9/27,Unknown significance,\N,intron_variant,2.203,0.001,1KG_EUR_AF,OTOA
387823,16:21711939:C>T,NM_144672.3:c.841-270C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,0.087,0.002,1KG_SAS_AF,OTOA
387824,16:21711965:G>T,NM_144672.3:c.841-244G>T,\N,\N,9/27,Unknown significance,\N,intron_variant,1.134,\N,\N,OTOA
387825,16:21711970:C>G,NM_144672.3:c.841-239C>G,\N,\N,9/27,Unknown significance,\N,intron_variant,0.699,\N,\N,OTOA
387826,16:21712017:G>T,NM_144672.3:c.841-192G>T,\N,\N,9/27,Unknown significance,\N,intron_variant,0.319,\N,\N,OTOA
387827,16:21712023:G>T,NM_144672.3:c.841-186G>T,\N,\N,9/27,Unknown significance,\N,intron_variant,0.551,0.002,1KG_EAS_AF,OTOA
387828,16:21712024:C>T,NM_144672.3:c.841-185C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,0.03,\N,\N,OTOA
387829,16:21712045:C>CAA,NM_144672.3:c.841-150_841-149dup,\N,\N,9/27,Benign,\N,intron_variant,10.77,0.6541,1KG_EUR_AF,OTOA
387830,16:21712045:C>CAAA,NM_144672.3:c.841-151_841-149dup,\N,\N,9/27,Unknown significance,\N,intron_variant,10.68,\N,\N,OTOA
387831,16:21712100:G>T,NM_144672.3:c.841-109G>T,\N,\N,9/27,Unknown significance,\N,intron_variant,3.272,\N,\N,OTOA
387832,16:21712161:C>T,NM_144672.3:c.841-48C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,5.222,\N,\N,OTOA
387833,16:21712168:C>T,NM_144672.3:c.841-41C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,2.001,0.0000962464,EXAC_AFR_AF,OTOA
387834,16:21712169:A>C,NM_144672.3:c.841-40A>C,\N,\N,9/27,Unknown significance,\N,intron_variant,2.918,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
387835,16:21712174:C>T,NM_144672.3:c.841-35C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,5.114,0.0000300066,EXAC_NFE_AF,OTOA
387836,16:21712187:C>T,NM_144672.3:c.841-22C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,4.964,0.000227376,EVS_AA_AF,OTOA
387837,16:21712189:C>G,NM_144672.3:c.841-20C>G,\N,\N,9/27,Unknown significance,\N,intron_variant,0.592,0.000121139,EXAC_SAS_AF,OTOA
387838,16:21712189:C>T,NM_144672.3:c.841-20C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,1.393,0.000227376,EVS_AA_AF,OTOA
387839,16:21712190:G>A,NM_144672.3:c.841-19G>A,\N,\N,9/27,Unknown significance,\N,intron_variant,0.299,0.0000605694,EXAC_SAS_AF,OTOA
387840,16:21712192:C>A,NM_144672.3:c.841-17C>A,\N,\N,9/27,Unknown significance,\N,intron_variant,4.093,0.000121139,EXAC_SAS_AF,OTOA
387841,16:21712195:T>C,NM_144672.3:c.841-14T>C,\N,\N,9/27,Unknown significance,\N,intron_variant,2.694,0.001,1KG_EAS_AF,OTOA
387842,16:21712199:C>A,NM_144672.3:c.841-10C>A,\N,\N,9/27,Unknown significance,\N,intron_variant,1.496,0.000116279,EVS_EA_AF,OTOA
387843,16:21712199:C>T,NM_144672.3:c.841-10C>T,\N,\N,9/27,Unknown significance,\N,intron_variant,1.398,0.0000149979,EXAC_NFE_AF,OTOA
387844,16:21712202:CA>C,NM_144672.3:c.841-5del,\N,\N,9/27,Unknown significance,\N,splice_region_variant&intron_variant,5.789,0.000231857,EXAC_EAS_AF,OTOA
387845,16:21712204:A>G,NM_144672.3:c.841-5A>G,\N,\N,9/27,Unknown significance,\N,splice_region_variant&intron_variant,0.471,0.0000962279,EXAC_AFR_AF,OTOA
387846,16:21712205:C>T,NM_144672.3:c.841-4C>T,\N,\N,9/27,Unknown significance,\N,splice_region_variant&intron_variant,3.735,0.0000605694,EXAC_SAS_AF,OTOA
387847,16:21712210:T>C,NM_001161683.1:c.605T>C,NP_001155155.1:p.Ile202Thr,6/24,\N,Unknown significance,\N,missense_variant&splice_region_variant,16.01,0.000227376,EVS_AA_AF,OTOA
387848,16:21712213:G>A,NM_144672.3:c.845G>A,NP_653273.3:p.Gly282Glu,10/28,\N,Unknown significance,\N,missense_variant,24.1,\N,\N,OTOA
387849,16:21712219:T>C,NM_144672.3:c.851T>C,NP_653273.3:p.Phe284Ser,10/28,\N,Unknown significance,\N,missense_variant,28.5,\N,\N,OTOA
387850,16:21712231:A>G,NM_144672.3:c.863A>G,NP_653273.3:p.Asp288Gly,10/28,\N,Unknown significance,\N,missense_variant,27.9,0.001,1KG_EAS_AF,OTOA
387851,16:21712235:C>T,NM_144672.3:c.867C>T,NP_653273.3:p.Asn289=,10/28,\N,Unknown significance,\N,synonymous_variant,14.38,0.0008,1KG_AFR_AF,OTOA
387852,16:21712237:C>T,NM_144672.3:c.869C>T,NP_653273.3:p.Ala290Val,10/28,\N,Unknown significance,\N,missense_variant,26.2,0.000060562,EXAC_SAS_AF,OTOA
387853,16:21712237:C>A,NM_144672.3:c.869C>A,NP_653273.3:p.Ala290Asp,10/28,\N,Unknown significance,\N,missense_variant,33,0.0025,OTO_JP_AF,OTOA
387854,16:21712243:A>G,NM_144672.3:c.875A>G,NP_653273.3:p.Lys292Arg,10/28,\N,Unknown significance,\N,missense_variant,27.3,0.000116279,EVS_EA_AF,OTOA
387855,16:21712244:G>A,NM_144672.3:c.876G>A,NP_653273.3:p.Lys292=,10/28,\N,Unknown significance,\N,synonymous_variant,13.21,0.000014988,EXAC_NFE_AF,OTOA
387856,16:21712250:G>A,NM_144672.3:c.882G>A,NP_653273.3:p.Leu294=,10/28,\N,Unknown significance,\N,synonymous_variant,9.885,0.0000149876,EXAC_NFE_AF,OTOA
387857,16:21712254:A>G,NM_144672.3:c.886A>G,NP_653273.3:p.Met296Val,10/28,\N,Unknown significance,\N,missense_variant,17.28,\N,\N,OTOA
387858,16:21712256:G>A,NM_144672.3:c.888G>A,NP_653273.3:p.Met296Ile,10/28,\N,Likely benign,\N,missense_variant,4.192,0.0000605767,EXAC_SAS_AF,OTOA
387859,16:21712257:G>A,NM_144672.3:c.889G>A,NP_653273.3:p.Val297Ile,10/28,\N,Unknown significance,\N,missense_variant,20.3,0.0000961354,EXAC_AFR_AF,OTOA
387860,16:21712257:G>T,NM_001161683.1:c.652G>T,NP_001155155.1:p.Val218Phe,6/24,\N,Unknown significance,\N,missense_variant,24.4,0.000029976,EXAC_NFE_AF,OTOA
387861,16:21712261:A>G,NM_144672.3:c.893A>G,NP_653273.3:p.Tyr298Cys,10/28,\N,Unknown significance,\N,missense_variant,26.1,\N,\N,OTOA
387862,16:21712279:T>G,NM_144672.3:c.911T>G,NP_653273.3:p.Leu304Arg,10/28,\N,Unknown significance,\N,missense_variant,27.1,0.0008,1KG_AFR_AF,OTOA
387863,16:21712280:G>A,NM_144672.3:c.912G>A,NP_653273.3:p.Leu304=,10/28,\N,Unknown significance,\N,synonymous_variant,11.17,0.0000605767,EXAC_SAS_AF,OTOA
387864,16:21712285:A>G,NM_144672.3:c.917A>G,NP_653273.3:p.Gln306Arg,10/28,\N,Likely benign,\N,missense_variant,11.85,0.0000149912,EXAC_NFE_AF,OTOA
387865,16:21712288:C>T,NM_001161683.1:c.683C>T,NP_001155155.1:p.Ala228Val,6/24,\N,Unknown significance,\N,missense_variant,28.7,0.000172951,EXAC_AMR_AF,OTOA
387866,16:21712289:G>A,NM_144672.3:c.921G>A,NP_653273.3:p.Ala307=,10/28,\N,Benign,\N,synonymous_variant,14.04,0.0089,1KG_EAS_AF,OTOA
387867,16:21712297:A>G,NM_144672.3:c.929A>G,NP_653273.3:p.Glu310Gly,10/28,\N,Benign,\N,missense_variant,23,0.00625,OTO_US_AF,OTOA
387868,16:21712316:C>T,NM_144672.3:c.948C>T,NP_653273.3:p.Asn316=,10/28,\N,Unknown significance,\N,synonymous_variant,12.13,0.0000962094,EXAC_AFR_AF,OTOA
387869,16:21712330:A>G,NM_001161683.1:c.725A>G,NP_001155155.1:p.Asn242Ser,6/24,\N,Unknown significance,\N,missense_variant,23.9,0.001,1KG_EAS_AF,OTOA
387870,16:21712332:A>C,NM_144672.3:c.964A>C,NP_653273.3:p.Thr322Pro,10/28,\N,Benign,\N,missense_variant,23.8,0.045,OTO_TR_AF,OTOA
387871,16:21712335:T>C,NM_144672.3:c.967T>C,NP_653273.3:p.Ser323Pro,10/28,\N,Unknown significance,\N,missense_variant,28.4,\N,\N,OTOA
387872,16:21712338:A>C,NM_144672.3:c.970A>C,NP_653273.3:p.Thr324Pro,10/28,\N,Benign,\N,missense_variant,25.1,0.02,OTO_TR_AF,OTOA
387873,16:21712354:C>T,NM_144672.3:c.980+6C>T,\N,\N,10/27,Likely benign,\N,splice_region_variant&intron_variant,9.689,0.000454752,EVS_AA_AF,OTOA
387874,16:21712355:G>A,NM_144672.3:c.980+7G>A,\N,\N,10/27,Unknown significance,\N,splice_region_variant&intron_variant,1.049,0.000348837,EVS_EA_AF,OTOA
387875,16:21712355:G>T,NM_144672.3:c.980+7G>T,\N,\N,10/27,Unknown significance,\N,splice_region_variant&intron_variant,0.628,0.003125,OTO_US_AF,OTOA
387876,16:21712367:G>A,NM_144672.3:c.980+19G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,5.657,0.0000972006,EXAC_AFR_AF,OTOA
387877,16:21712374:G>A,NM_144672.3:c.980+26G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,4.233,0.001,1KG_EAS_AF,OTOA
387878,16:21712376:G>C,NM_144672.3:c.980+28G>C,\N,\N,10/27,Unknown significance,\N,intron_variant,1.568,0.000151745,EXAC_FIN_AF,OTOA
387879,16:21712384:C>T,NM_144672.3:c.980+36C>T,\N,\N,10/27,Likely benign,\N,intron_variant,6.146,0.0000304192,EXAC_NFE_AF,OTOA
387880,16:21712390:T>C,NM_144672.3:c.980+42T>C,\N,\N,10/27,Likely benign,\N,intron_variant,4.277,0.0000615233,EXAC_SAS_AF,OTOA
387881,16:21712400:G>A,NM_144672.3:c.980+52G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,4.401,0.001,1KG_EAS_AF,OTOA
387882,16:21712415:G>A,NM_144672.3:c.980+67G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,9.426,0.0000896539,EXAC_AMR_AF,OTOA
387883,16:21712426:C>T,NM_144672.3:c.980+78C>T,\N,\N,10/27,Benign,\N,intron_variant,2.57,0.0621641,EXAC_EAS_AF,OTOA
387884,16:21712430:C>T,NM_144672.3:c.980+82C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,3.997,0.0000632111,EXAC_SAS_AF,OTOA
387885,16:21712437:G>A,NM_144672.3:c.980+89G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,3.278,0.0000644039,EXAC_NFE_AF,OTOA
387886,16:21712465:G>T,NM_144672.3:c.980+117G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.279,0.001,1KG_EAS_AF,OTOA
387887,16:21712477:A>G,NM_144672.3:c.980+129A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,0.074,\N,\N,OTOA
387888,16:21712508:C>T,NM_144672.3:c.980+160C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,2.786,0.001,1KG_EAS_AF,OTOA
387889,16:21712551:A>G,NM_144672.3:c.980+203A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,5.126,\N,\N,OTOA
387890,16:21712590:G>A,NM_144672.3:c.980+242G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,2.094,\N,\N,OTOA
387891,16:21712688:G>A,NM_144672.3:c.980+340G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.541,0.001,1KG_SAS_AF,OTOA
387892,16:21712720:A>G,NM_144672.3:c.980+372A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,0.849,0.004,1KG_EAS_AF,OTOA
387893,16:21712721:TG>T,NM_144672.3:c.980+376del,\N,\N,10/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387894,16:21712742:C>T,NM_144672.3:c.980+394C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,10.66,0.0014,1KG_AMR_AF,OTOA
387895,16:21712743:G>A,NM_144672.3:c.980+395G>A,\N,\N,10/27,Benign,\N,intron_variant,9.255,0.4742,1KG_EUR_AF,OTOA
387896,16:21712753:A>G,NM_144672.3:c.980+405A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,6.698,\N,\N,OTOA
387897,16:21712770:GC>G,NM_144672.3:c.980+426del,\N,\N,10/27,Unknown significance,\N,intron_variant,2.142,0.0038,1KG_AFR_AF,OTOA
387898,16:21712773:C>T,NM_144672.3:c.980+425C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,4.389,0.0038,1KG_AFR_AF,OTOA
387899,16:21712883:G>A,NM_144672.3:c.980+535G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,7.885,0.002,1KG_EAS_AF,OTOA
387900,16:21712897:G>T,NM_144672.3:c.980+549G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,1.346,0.0015,1KG_AFR_AF,OTOA
387901,16:21712938:TTTTA>T,NM_144672.3:c.980+602_980+605del,\N,\N,10/27,Unknown significance,\N,intron_variant,3.824,\N,\N,OTOA
387902,16:21712982:C>T,NM_144672.3:c.980+634C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,1.756,0.001,1KG_EAS_AF,OTOA
387903,16:21712985:G>C,NM_144672.3:c.980+637G>C,\N,\N,10/27,Unknown significance,\N,intron_variant,0.227,\N,\N,OTOA
387904,16:21713008:T>A,NM_144672.3:c.980+660T>A,\N,\N,10/27,Unknown significance,\N,intron_variant,1.632,0.001,1KG_SAS_AF,OTOA
387905,16:21713046:C>G,NM_144672.3:c.980+698C>G,\N,\N,10/27,Unknown significance,\N,intron_variant,2.515,\N,\N,OTOA
387906,16:21713088:T>C,NM_144672.3:c.980+740T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,12.42,\N,\N,OTOA
387907,16:21713096:T>C,NM_144672.3:c.980+748T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,11.6,\N,\N,OTOA
387908,16:21713098:C>T,NM_144672.3:c.980+750C>T,\N,\N,10/27,Benign,\N,intron_variant,11.85,0.006,1KG_EAS_AF,OTOA
387909,16:21713107:AT>A,NM_144672.3:c.980+765del,\N,\N,10/27,Unknown significance,\N,intron_variant,0.384,\N,\N,OTOA
387910,16:21713170:G>A,NM_144672.3:c.980+822G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.971,0.0008,1KG_AFR_AF,OTOA
387911,16:21713173:C>G,NM_144672.3:c.980+825C>G,\N,\N,10/27,Unknown significance,\N,intron_variant,0.665,\N,\N,OTOA
387912,16:21713183:G>T,NM_144672.3:c.980+835G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.131,\N,\N,OTOA
387913,16:21713267:CTG>C,NM_144672.3:c.980+921_980+922del,\N,\N,10/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387914,16:21713269:GTT>G,NM_144672.3:c.980+940_980+941del,\N,\N,10/27,Benign,\N,intron_variant,3.382,0.8344,1KG_SAS_AF,OTOA
387915,16:21713269:GTTT>G,NM_144672.3:c.980+939_980+941del,\N,\N,10/27,Unknown significance,\N,intron_variant,3.236,\N,\N,OTOA
387916,16:21713343:C>T,NM_144672.3:c.980+995C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,10.23,\N,\N,OTOA
387917,16:21713345:C>T,NM_144672.3:c.980+997C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,10.63,0.002,1KG_EUR_AF,OTOA
387918,16:21713371:A>G,NM_144672.3:c.980+1023A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,3.58,0.001,1KG_SAS_AF,OTOA
387919,16:21713390:C>G,NM_144672.3:c.980+1042C>G,\N,\N,10/27,Unknown significance,\N,intron_variant,0.372,\N,\N,OTOA
387920,16:21713396:A>G,NM_144672.3:c.980+1048A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,0.3,0.001,1KG_EAS_AF,OTOA
387921,16:21713415:C>T,NM_144672.3:c.980+1067C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,1.965,0.001,1KG_SAS_AF,OTOA
387922,16:21713416:G>A,NM_144672.3:c.980+1068G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.051,0.002,1KG_EUR_AF,OTOA
387923,16:21713418:G>A,NM_144672.3:c.980+1070G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.416,\N,\N,OTOA
387924,16:21713429:C>G,NM_144672.3:c.980+1081C>G,\N,\N,10/27,Unknown significance,\N,intron_variant,1.129,0.0008,1KG_AFR_AF,OTOA
387925,16:21713439:T>C,NM_144672.3:c.980+1091T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,2.291,0.0023,1KG_AFR_AF,OTOA
387926,16:21713467:C>T,NM_144672.3:c.980+1119C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.443,0.001,1KG_EUR_AF,OTOA
387927,16:21713481:G>A,NM_144672.3:c.980+1133G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,1.839,0.001,1KG_SAS_AF,OTOA
387928,16:21713548:G>A,NM_144672.3:c.980+1200G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,2.259,\N,\N,OTOA
387929,16:21713550:C>T,NM_144672.3:c.980+1202C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.514,0.001,1KG_EAS_AF,OTOA
387930,16:21713551:G>A,NM_144672.3:c.980+1203G>A,\N,\N,10/27,Benign,\N,intron_variant,0.064,0.0083,1KG_AFR_AF,OTOA
387931,16:21713569:C>A,NM_144672.3:c.980+1221C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,3.045,\N,\N,OTOA
387932,16:21713587:G>T,NM_144672.3:c.980+1239G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.05,0.001,1KG_SAS_AF,OTOA
387933,16:21713593:G>A,NM_144672.3:c.980+1245G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.941,\N,\N,OTOA
387934,16:21713647:T>C,NM_144672.3:c.980+1299T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,1.604,\N,\N,OTOA
387935,16:21713671:G>T,NM_144672.3:c.980+1323G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.367,0.0014,1KG_AMR_AF,OTOA
387936,16:21713689:C>T,NM_144672.3:c.980+1341C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,2.039,0.0008,1KG_AFR_AF,OTOA
387937,16:21713709:A>G,NM_144672.3:c.980+1361A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,5.755,0.0023,1KG_AFR_AF,OTOA
387938,16:21713722:T>G,NM_144672.3:c.980+1374T>G,\N,\N,10/27,Unknown significance,\N,intron_variant,3.992,\N,\N,OTOA
387939,16:21713855:T>C,NM_144672.3:c.980+1507T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,1.834,\N,\N,OTOA
387940,16:21713875:C>G,NM_144672.3:c.980+1527C>G,\N,\N,10/27,Unknown significance,\N,intron_variant,1.766,\N,\N,OTOA
387941,16:21713878:T>C,NM_144672.3:c.980+1530T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,2.934,0.0008,1KG_AFR_AF,OTOA
387942,16:21713885:C>T,NM_144672.3:c.980+1537C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,4.233,0.001,1KG_EAS_AF,OTOA
387943,16:21713887:G>A,NM_144672.3:c.980+1539G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.611,\N,\N,OTOA
387944,16:21713894:C>T,NM_144672.3:c.980+1546C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,5.796,0.001,1KG_EUR_AF,OTOA
387945,16:21713903:A>G,NM_144672.3:c.980+1555A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,5.247,\N,\N,OTOA
387946,16:21713952:G>A,NM_144672.3:c.980+1604G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,2.967,\N,\N,OTOA
387947,16:21714020:C>T,NM_144672.3:c.980+1672C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.606,0.001,1KG_SAS_AF,OTOA
387948,16:21714059:C>T,NM_144672.3:c.980+1711C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,1.38,\N,\N,OTOA
387949,16:21714077:A>G,NM_144672.3:c.980+1729A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,3.52,\N,\N,OTOA
387950,16:21714078:C>T,NM_144672.3:c.980+1730C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,1.961,0.002,1KG_EUR_AF,OTOA
387951,16:21714080:T>TC,NM_144672.3:c.980+1733dup,\N,\N,10/27,Unknown significance,\N,intron_variant,0.577,0.0023,1KG_AFR_AF,OTOA
387952,16:21714111:C>A,NM_144672.3:c.980+1763C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,3.828,\N,\N,OTOA
387953,16:21714145:C>T,NM_144672.3:c.980+1797C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.166,0.001,1KG_EUR_AF|1KG_SAS_AF,OTOA
387954,16:21714153:C>T,NM_144672.3:c.980+1805C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.169,0.001,1KG_EUR_AF,OTOA
387955,16:21714176:T>C,NM_144672.3:c.980+1828T>C,\N,\N,10/27,Benign,\N,intron_variant,2.538,0.0053,1KG_AFR_AF,OTOA
387956,16:21714228:C>A,NM_144672.3:c.980+1880C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,4.655,0.0008,1KG_AFR_AF,OTOA
387957,16:21714238:G>A,NM_144672.3:c.980+1890G>A,\N,\N,10/27,Benign,\N,intron_variant,0.23,0.2625,1KG_AFR_AF,OTOA
387958,16:21714242:G>A,NM_144672.3:c.980+1894G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.193,\N,\N,OTOA
387959,16:21714286:C>T,NM_144672.3:c.980+1938C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.17,0.001,1KG_EUR_AF,OTOA
387960,16:21714308:T>A,NM_144672.3:c.980+1960T>A,\N,\N,10/27,Unknown significance,\N,intron_variant,8.5,0.001,1KG_EUR_AF,OTOA
387961,16:21714324:AT>A,NM_144672.3:c.980+1978del,\N,\N,10/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
387962,16:21714349:G>A,NM_144672.3:c.980+2001G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,11.28,0.001,1KG_EAS_AF,OTOA
387963,16:21714389:G>A,NM_144672.3:c.980+2041G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,12.45,0.0008,1KG_AFR_AF,OTOA
387964,16:21714416:T>G,NM_144672.3:c.980+2068T>G,\N,\N,10/27,Unknown significance,\N,intron_variant,5.946,\N,\N,OTOA
387965,16:21714480:A>G,NM_144672.3:c.981-2010A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,0.939,0.001,1KG_SAS_AF,OTOA
387966,16:21714484:T>C,NM_144672.3:c.981-2006T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,0.407,0.0029,1KG_AMR_AF,OTOA
387967,16:21714541:A>G,NM_144672.3:c.981-1949A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,7.84,0.001,1KG_EAS_AF,OTOA
387968,16:21714546:A>G,NM_144672.3:c.981-1944A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,9.211,\N,\N,OTOA
387969,16:21714561:C>T,NM_144672.3:c.981-1929C>T,\N,\N,10/27,Benign,\N,intron_variant,5.97,0.0393,1KG_AFR_AF,OTOA
387970,16:21714587:T>C,NM_144672.3:c.981-1903T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,3.005,0.002,1KG_EAS_AF,OTOA
387971,16:21714589:C>T,NM_144672.3:c.981-1901C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,5.254,\N,\N,OTOA
387972,16:21714645:G>A,NM_144672.3:c.981-1845G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,2.986,0.004,1KG_EAS_AF,OTOA
387973,16:21714649:G>T,NM_144672.3:c.981-1841G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,1.154,0.0023,1KG_AFR_AF,OTOA
387974,16:21714723:C>T,NM_144672.3:c.981-1767C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.681,0.001,1KG_EUR_AF,OTOA
387975,16:21714763:A>G,NM_144672.3:c.981-1727A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,2.293,0.0023,1KG_AFR_AF,OTOA
387976,16:21714805:T>C,NM_144672.3:c.981-1685T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,1.506,\N,\N,OTOA
387977,16:21714822:TA>T,NM_144672.3:c.981-1658del,\N,\N,10/27,Unknown significance,\N,intron_variant,4.944,\N,\N,OTOA
387978,16:21714823:A>T,NM_144672.3:c.981-1667A>T,\N,\N,10/27,Unknown significance,\N,intron_variant,1.507,0.0023,1KG_AFR_AF,OTOA
387979,16:21714849:C>T,NM_144672.3:c.981-1641C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,1.725,0.003,1KG_AFR_AF,OTOA
387980,16:21714850:G>A,NM_144672.3:c.981-1640G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.35,0.0008,1KG_AFR_AF,OTOA
387981,16:21714864:G>A,NM_144672.3:c.981-1626G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,4.051,0.001,1KG_EUR_AF,OTOA
387982,16:21714866:A>G,NM_144672.3:c.981-1624A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,0.77,\N,\N,OTOA
387983,16:21714882:G>T,NM_144672.3:c.981-1608G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.95,0.0008,1KG_AFR_AF,OTOA
387984,16:21714906:C>T,NM_144672.3:c.981-1584C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,6.553,\N,\N,OTOA
387985,16:21714918:C>T,NM_144672.3:c.981-1572C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,5.292,\N,\N,OTOA
387986,16:21714919:G>A,NM_144672.3:c.981-1571G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,3.177,0.0014,1KG_AMR_AF,OTOA
387987,16:21714932:T>C,NM_144672.3:c.981-1558T>C,\N,\N,10/27,Benign,\N,intron_variant,0.97,0.0219,1KG_AFR_AF,OTOA
387988,16:21714951:C>T,NM_144672.3:c.981-1539C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,4.314,0.001,1KG_EAS_AF,OTOA
387989,16:21714956:A>G,NM_144672.3:c.981-1534A>G,\N,\N,10/27,Benign,\N,intron_variant,1.469,0.1543,1KG_AFR_AF,OTOA
387990,16:21715004:C>T,NM_144672.3:c.981-1486C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,5.472,0.0008,1KG_AFR_AF,OTOA
387991,16:21715059:G>A,NM_144672.3:c.981-1431G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,7.261,\N,\N,OTOA
387992,16:21715091:G>T,NM_144672.3:c.981-1399G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.363,\N,\N,OTOA
387993,16:21715108:C>G,NM_144672.3:c.981-1382C>G,\N,\N,10/27,Benign,\N,intron_variant,3.38,0.2628,1KG_SAS_AF,OTOA
387994,16:21715120:T>A,NM_144672.3:c.981-1370T>A,\N,\N,10/27,Unknown significance,\N,intron_variant,7.5,0.001,1KG_EUR_AF,OTOA
387995,16:21715151:G>A,NM_144672.3:c.981-1339G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,1.523,\N,\N,OTOA
387996,16:21715173:A>G,NM_144672.3:c.981-1317A>G,\N,\N,10/27,Benign,\N,intron_variant,1.906,0.0079,1KG_EAS_AF,OTOA
387997,16:21715175:A>G,NM_144672.3:c.981-1315A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,1.288,0.0008,1KG_AFR_AF,OTOA
387998,16:21715201:C>A,NM_144672.3:c.981-1289C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,8.876,\N,\N,OTOA
387999,16:21715230:T>G,NM_144672.3:c.981-1260T>G,\N,\N,10/27,Unknown significance,\N,intron_variant,8.469,\N,\N,OTOA
388000,16:21715240:C>T,NM_144672.3:c.981-1250C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,6.143,0.002,1KG_EAS_AF,OTOA
388001,16:21715282:G>C,NM_144672.3:c.981-1208G>C,\N,\N,10/27,Unknown significance,\N,intron_variant,0.866,\N,\N,OTOA
388002,16:21715322:G>GT,NM_144672.3:c.981-1167dup,\N,\N,10/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388003,16:21715350:C>A,NM_144672.3:c.981-1140C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,5.46,0.001,1KG_EAS_AF,OTOA
388004,16:21715374:G>A,NM_144672.3:c.981-1116G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,1.973,0.001,1KG_EAS_AF,OTOA
388005,16:21715399:C>A,NM_144672.3:c.981-1091C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,3.706,0.0014,1KG_AMR_AF,OTOA
388006,16:21715433:C>T,NM_144672.3:c.981-1057C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,3.789,\N,\N,OTOA
388007,16:21715492:C>G,NM_144672.3:c.981-998C>G,\N,\N,10/27,Unknown significance,\N,intron_variant,2.886,\N,\N,OTOA
388008,16:21715498:T>C,NM_144672.3:c.981-992T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,0.104,0.001,1KG_EAS_AF,OTOA
388009,16:21715529:C>T,NM_144672.3:c.981-961C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,5.765,0.001,1KG_SAS_AF,OTOA
388010,16:21715550:G>A,NM_144672.3:c.981-940G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,11.16,0.001,1KG_EAS_AF,OTOA
388011,16:21715555:G>A,NM_144672.3:c.981-935G>A,\N,\N,10/27,Benign,\N,intron_variant,9.255,0.005,1KG_EUR_AF,OTOA
388012,16:21715604:G>A,NM_144672.3:c.981-886G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,2.569,0.0023,1KG_AFR_AF,OTOA
388013,16:21715630:G>C,NM_144672.3:c.981-860G>C,\N,\N,10/27,Unknown significance,\N,intron_variant,0.236,0.002,1KG_EUR_AF,OTOA
388014,16:21715634:G>A,NM_144672.3:c.981-856G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,1.383,\N,\N,OTOA
388015,16:21715668:C>T,NM_144672.3:c.981-822C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.299,0.002,1KG_SAS_AF,OTOA
388016,16:21715672:AC>A,NM_144672.3:c.981-816del,\N,\N,10/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388017,16:21715763:C>T,NM_144672.3:c.981-727C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,2.665,\N,\N,OTOA
388018,16:21715767:G>A,NM_144672.3:c.981-723G>A,\N,\N,10/27,Benign,\N,intron_variant,3.074,0.0083,1KG_AFR_AF,OTOA
388019,16:21715780:C>T,NM_144672.3:c.981-710C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,12.3,0.0008,1KG_AFR_AF,OTOA
388020,16:21715843:G>A,NM_144672.3:c.981-647G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,8.075,0.002,1KG_EUR_AF,OTOA
388021,16:21715860:C>T,NM_144672.3:c.981-630C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.819,0.001,1KG_EUR_AF,OTOA
388022,16:21715909:G>T,NM_144672.3:c.981-581G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.564,0.0008,1KG_AFR_AF,OTOA
388023,16:21715961:G>A,NM_144672.3:c.981-529G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,6.315,0.001,1KG_SAS_AF,OTOA
388024,16:21715969:A>G,NM_144672.3:c.981-521A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,8.73,\N,\N,OTOA
388025,16:21715982:G>A,NM_144672.3:c.981-508G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,12.72,\N,\N,OTOA
388026,16:21715983:G>A,NM_144672.3:c.981-507G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,12.74,0.0008,1KG_AFR_AF,OTOA
388027,16:21715983:G>C,NM_144672.3:c.981-507G>C,\N,\N,10/27,Unknown significance,\N,intron_variant,10.86,\N,\N,OTOA
388028,16:21716025:A>G,NM_144672.3:c.981-465A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,11.66,0.0008,1KG_AFR_AF,OTOA
388029,16:21716041:G>C,NM_144672.3:c.981-449G>C,\N,\N,10/27,Unknown significance,\N,intron_variant,5.633,\N,\N,OTOA
388030,16:21716055:G>A,NM_144672.3:c.981-435G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,2.307,0.001,1KG_EUR_AF,OTOA
388031,16:21716097:G>A,NM_144672.3:c.981-393G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,4.765,\N,\N,OTOA
388032,16:21716106:A>G,NM_144672.3:c.981-384A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,5.658,0.001,1KG_SAS_AF,OTOA
388033,16:21716113:G>A,NM_144672.3:c.981-377G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,3.802,0.001,1KG_EUR_AF,OTOA
388034,16:21716134:C>CGGA,NM_144672.3:c.981-353_981-351dup,\N,\N,10/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388035,16:21716134:CGGA>C,NM_144672.3:c.981-353_981-351del,\N,\N,10/27,Benign,\N,intron_variant,7.32,0.0595,1KG_EAS_AF,OTOA
388036,16:21716136:GA>G,NM_144672.3:c.981-353del,\N,\N,10/27,Unknown significance,\N,intron_variant,4.5,\N,\N,OTOA
388037,16:21716151:T>G,NM_144672.3:c.981-339T>G,\N,\N,10/27,Unknown significance,\N,intron_variant,10.63,\N,\N,OTOA
388038,16:21716162:G>A,NM_144672.3:c.981-328G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,11.42,\N,\N,OTOA
388039,16:21716179:A>T,NM_144672.3:c.981-311A>T,\N,\N,10/27,Unknown significance,\N,intron_variant,9.243,\N,\N,OTOA
388040,16:21716189:G>A,NM_144672.3:c.981-301G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,10.12,\N,\N,OTOA
388041,16:21716200:T>C,NM_144672.3:c.981-290T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,7.881,0.0045,1KG_AFR_AF,OTOA
388042,16:21716246:G>A,NM_144672.3:c.981-244G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.771,\N,\N,OTOA
388043,16:21716250:A>T,NM_144672.3:c.981-240A>T,\N,\N,10/27,Unknown significance,\N,intron_variant,2.69,0.001,1KG_SAS_AF,OTOA
388044,16:21716252:C>T,NM_144672.3:c.981-238C>T,\N,\N,10/27,Benign,\N,intron_variant,4.204,0.034,1KG_AFR_AF,OTOA
388045,16:21716264:T>C,NM_144672.3:c.981-226T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,2.858,0.000314268,EVS_EA_AF,OTOA
388046,16:21716295:G>T,NM_144672.3:c.981-195G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.738,0.000722543,EVS_AA_AF,OTOA
388047,16:21716296:G>A,NM_144672.3:c.981-194G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,1.195,0.001,1KG_SAS_AF,OTOA
388048,16:21716298:C>G,NM_144672.3:c.981-192C>G,\N,\N,10/27,Unknown significance,\N,intron_variant,1.62,\N,\N,OTOA
388049,16:21716300:C>A,NM_144672.3:c.981-190C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.206,0.0000960984,EXAC_AFR_AF,OTOA
388050,16:21716300:C>T,NM_144672.3:c.981-190C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.198,0.000115554,EXAC_EAS_AF,OTOA
388051,16:21716301:G>A,NM_144672.3:c.981-189G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.997,0.000181686,EXAC_SAS_AF,OTOA
388052,16:21716301:G>C,NM_144672.3:c.981-189G>C,\N,\N,10/27,Unknown significance,\N,intron_variant,0.188,0.000346661,EXAC_EAS_AF,OTOA
388053,16:21716302:T>A,NM_144672.3:c.981-188T>A,\N,\N,10/27,Unknown significance,\N,intron_variant,3.845,0.00211416,EXAC_AFR_AF,OTOA
388054,16:21716302:T>C,NM_144672.3:c.981-188T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,1.151,0.0000960984,EXAC_AFR_AF,OTOA
388055,16:21716304:T>G,NM_144672.3:c.981-186T>G,\N,\N,10/27,Unknown significance,\N,intron_variant,2.401,0.000907167,EXAC_FIN_AF,OTOA
388056,16:21716307:G>A,NM_144672.3:c.981-183G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,1.884,0.000464489,EXAC_NFE_AF,OTOA
388057,16:21716315:G>T,NM_144672.3:c.981-175G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.594,0.000060562,EXAC_SAS_AF,OTOA
388058,16:21716318:C>T,NM_144672.3:c.981-172C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,3.022,\N,\N,OTOA
388059,16:21716319:C>T,NM_144672.3:c.981-171C>T,\N,\N,10/27,Benign,\N,intron_variant,0.514,0.00682128,EVS_AA_AF,OTOA
388060,16:21716320:G>A,NM_144672.3:c.981-170G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.32,0.001,1KG_SAS_AF,OTOA
388061,16:21716322:C>T,NM_144672.3:c.981-168C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,2.375,0.0000863707,EXAC_AMR_AF,OTOA
388062,16:21716327:G>A,NM_144672.3:c.981-163G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.608,0.000179808,EXAC_NFE_AF,OTOA
388063,16:21716327:G>T,NM_144672.3:c.981-163G>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.142,0.0000960984,EXAC_AFR_AF,OTOA
388064,16:21716335:T>G,NM_144672.3:c.981-155T>G,\N,\N,10/27,Unknown significance,\N,intron_variant,1.57,0.001,1KG_SAS_AF,OTOA
388065,16:21716343:A>G,NM_144672.3:c.981-147A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,3.171,\N,\N,OTOA
388066,16:21716344:T>C,NM_144672.3:c.981-146T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,1.654,0.0000960984,EXAC_AFR_AF,OTOA
388067,16:21716353:G>A,NM_170664.2:c.3G>A,NP_733764.1:p.Met1?,1/19,\N,Unknown significance,\N,start_lost,3.014,\N,\N,OTOA
388068,16:21716365:T>C,NM_170664.2:c.8+7T>C,\N,\N,1/18,Unknown significance,\N,splice_region_variant&intron_variant,1.642,0.001,1KG_EUR_AF,OTOA
388069,16:21716376:C>T,NM_144672.3:c.981-114C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,0.528,\N,\N,OTOA
388070,16:21716380:G>A,NM_144672.3:c.981-110G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,2.212,0.000227376,EVS_AA_AF,OTOA
388071,16:21716382:G>C,NM_144672.3:c.981-108G>C,\N,\N,10/27,Unknown significance,\N,intron_variant,0.351,0.0000149835,EXAC_NFE_AF,OTOA
388072,16:21716383:T>A,NM_144672.3:c.981-107T>A,\N,\N,10/27,Unknown significance,\N,intron_variant,5.9,0.0000599341,EXAC_NFE_AF,OTOA
388073,16:21716384:C>T,NM_144672.3:c.981-106C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,3.2,0.0000863856,EXAC_AMR_AF,OTOA
388074,16:21716385:C>A,NM_144672.3:c.981-105C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,2.146,0.00110132,EXAC_OTH_AF,OTOA
388075,16:21716386:G>A,NM_144672.3:c.981-104G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.404,0.000227376,EVS_AA_AF,OTOA
388076,16:21716390:C>G,NM_144672.3:c.981-100C>G,\N,\N,10/27,Unknown significance,\N,intron_variant,2.005,\N,\N,OTOA
388077,16:21716404:C>T,NM_144672.3:c.981-86C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,1.965,0.0000863856,EXAC_AMR_AF,OTOA
388078,16:21716408:C>T,NM_144672.3:c.981-82C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,2.451,0.0000863856,EXAC_AMR_AF,OTOA
388079,16:21716419:C>A,NM_144672.3:c.981-71C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,2.284,0.0008,1KG_AFR_AF,OTOA
388080,16:21716447:C>T,NM_144672.3:c.981-43C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,3.309,0.001,1KG_EUR_AF,OTOA
388081,16:21716451:G>A,NM_144672.3:c.981-39G>A,\N,\N,10/27,Unknown significance,\N,intron_variant,0.684,0.000060562,EXAC_SAS_AF,OTOA
388082,16:21716457:A>G,NM_144672.3:c.981-33A>G,\N,\N,10/27,Unknown significance,\N,intron_variant,2.624,\N,\N,OTOA
388083,16:21716457:A>C,NM_144672.3:c.981-33A>C,\N,\N,10/27,Unknown significance,\N,intron_variant,1.095,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
388084,16:21716464:C>A,NM_144672.3:c.981-26C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,5.339,0.000115687,EXAC_EAS_AF,OTOA
388085,16:21716465:C>A,NM_144672.3:c.981-25C>A,\N,\N,10/27,Unknown significance,\N,intron_variant,4.769,0.000014984,EXAC_NFE_AF,OTOA
388086,16:21716466:A>C,NM_144672.3:c.981-24A>C,\N,\N,10/27,Unknown significance,\N,intron_variant,3.567,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
388087,16:21716476:C>T,NM_144672.3:c.981-14C>T,\N,\N,10/27,Unknown significance,\N,intron_variant,8.497,0.000227376,EVS_AA_AF,OTOA
388088,16:21716480:T>C,NM_144672.3:c.981-10T>C,\N,\N,10/27,Unknown significance,\N,intron_variant,11.26,0.0000149835,EXAC_NFE_AF,OTOA
388089,16:21716483:C>T,NM_144672.3:c.981-7C>T,\N,\N,10/27,Unknown significance,\N,splice_region_variant&intron_variant,14.39,0.000060562,EXAC_SAS_AF,OTOA
388090,16:21716493:G>A,NM_144672.3:c.984G>A,NP_653273.3:p.Leu328=,11/28,\N,Unknown significance,\N,synonymous_variant,10.48,0.0000149835,EXAC_NFE_AF,OTOA
388091,16:21716495:G>A,NM_144672.3:c.986G>A,NP_653273.3:p.Gly329Glu,11/28,\N,Unknown significance,\N,missense_variant,28.3,0.000151194,EXAC_FIN_AF,OTOA
388092,16:21716496:G>A,NM_144672.3:c.987G>A,NP_653273.3:p.Gly329=,11/28,\N,Unknown significance,\N,synonymous_variant,11,0.0000149835,EXAC_NFE_AF,OTOA
388093,16:21716504:T>C,NM_144672.3:c.995T>C,NP_653273.3:p.Val332Ala,11/28,\N,Unknown significance,\N,missense_variant,23.5,0.000909504,EVS_AA_AF,OTOA
388094,16:21716507:G>A,NM_144672.3:c.998G>A,NP_653273.3:p.Cys333Tyr,11/28,\N,Unknown significance,\N,missense_variant,28.2,0.0000149835,EXAC_NFE_AF,OTOA
388095,16:21716513:A>G,NM_144672.3:c.1004A>G,NP_653273.3:p.Tyr335Cys,11/28,\N,Unknown significance,\N,missense_variant,25.1,0.0000149835,EXAC_NFE_AF,OTOA
388096,16:21716516:A>G,NM_144672.3:c.1007A>G,NP_653273.3:p.Asn336Ser,11/28,\N,Unknown significance,\N,missense_variant,10.87,0.000863707,EXAC_AMR_AF,OTOA
388097,16:21716534:A>T,NM_144672.3:c.1025A>T,NP_653273.3:p.Asp342Val,11/28,\N,Pathogenic,Hearing loss| non-syndromic,missense_variant,26.7,\N,\N,OTOA
388098,16:21716535:T>A,NM_170664.2:c.54T>A,NP_733764.1:p.Asp18Glu,2/19,\N,Likely benign,\N,missense_variant,14.48,0.0000863707,EXAC_AMR_AF,OTOA
388099,16:21716542:G>A,NM_144672.3:c.1033G>A,NP_653273.3:p.Val345Met,11/28,\N,Likely benign,\N,missense_variant,10.91,0.0000863707,EXAC_AMR_AF,OTOA
388100,16:21716545:G>A,NM_144672.3:c.1036G>A,NP_653273.3:p.Ala346Thr,11/28,\N,Unknown significance,\N,missense_variant,25.4,\N,\N,OTOA
388101,16:21716565:G>GTC,NM_144672.3:c.1056_1057insTC,NP_653273.3:p.Met353SerfsTer2,11/28,\N,Unknown significance,\N,frameshift_variant,34,0.00011566,EXAC_EAS_AF,OTOA
388102,16:21716567:T>C,NM_144672.3:c.1058T>C,NP_653273.3:p.Met353Thr,11/28,\N,Unknown significance,\N,missense_variant,24.1,0.00004496,EXAC_NFE_AF,OTOA
388103,16:21716577:C>T,NM_144672.3:c.1068C>T,NP_653273.3:p.Cys356=,11/28,\N,Unknown significance,\N,synonymous_variant,11.98,0.000060562,EXAC_SAS_AF,OTOA
388104,16:21716582:A>T,NM_144672.3:c.1073A>T,NP_653273.3:p.His358Leu,11/28,\N,Likely benign,\N,missense_variant,14.94,0.000172741,EXAC_AMR_AF,OTOA
388105,16:21716592:C>T,NM_144672.3:c.1083C>T,NP_653273.3:p.Gly361=,11/28,\N,Unknown significance,\N,synonymous_variant,13.98,\N,\N,OTOA
388106,16:21716595:C>T,NM_144672.3:c.1086C>T,NP_653273.3:p.Phe362=,11/28,\N,Unknown significance,\N,synonymous_variant,14.5,0.0000863707,EXAC_AMR_AF,OTOA
388107,16:21716599:G>A,NM_144672.3:c.1090G>A,NP_653273.3:p.Ala364Thr,11/28,\N,Unknown significance,\N,missense_variant,24.3,0.000465116,EVS_EA_AF,OTOA
388108,16:21716603:G>A,NM_144672.3:c.1094G>A,NP_653273.3:p.Gly365Asp,11/28,\N,Likely benign,\N,missense_variant,0.008,0.0000299868,EXAC_NFE_AF,OTOA
388109,16:21716604:C>T,NM_144672.3:c.1095C>T,NP_653273.3:p.Gly365=,11/28,\N,Benign,\N,synonymous_variant,10.89,0.0365877,EXAC_AFR_AF,OTOA
388110,16:21716605:G>A,NM_144672.3:c.1096G>A,NP_653273.3:p.Val366Ile,11/28,\N,Unknown significance,\N,missense_variant,10.59,0.000115741,EXAC_EAS_AF,OTOA
388111,16:21716611:A>G,NM_144672.3:c.1102A>G,NP_653273.3:p.Lys368Glu,11/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,12.41,0.000060562,EXAC_SAS_AF,OTOA
388112,16:21716615:T>G,NM_144672.3:c.1104+2T>G,\N,\N,11/27,Unknown significance,\N,splice_donor_variant,23.1,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
388113,16:21716617:C>G,NM_144672.3:c.1104+4C>G,\N,\N,11/27,Unknown significance,\N,splice_region_variant&intron_variant,5.352,0.000259112,EXAC_AMR_AF,OTOA
388114,16:21716620:C>G,NM_144672.3:c.1104+7C>G,\N,\N,11/27,Unknown significance,\N,splice_region_variant&intron_variant,2.204,0.0000150006,EXAC_NFE_AF,OTOA
388115,16:21716625:G>C,NM_144672.3:c.1104+12G>C,\N,\N,11/27,Likely benign,\N,intron_variant,1.464,0.000015006,EXAC_NFE_AF,OTOA
388116,16:21716625:G>A,NM_144672.3:c.1104+12G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,4.675,0.000116279,EVS_EA_AF,OTOA
388117,16:21716625:G>T,NM_144672.3:c.1104+12G>T,\N,\N,11/27,Unknown significance,\N,intron_variant,2.329,0.000060562,EXAC_SAS_AF,OTOA
388118,16:21716640:G>C,NM_144672.3:c.1104+27G>C,\N,\N,11/27,Unknown significance,\N,intron_variant,3.644,0.0000150173,EXAC_NFE_AF,OTOA
388119,16:21716641:C>T,NM_144672.3:c.1104+28C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,8.549,0.000060562,EXAC_SAS_AF,OTOA
388120,16:21716644:C>T,NM_144672.3:c.1104+31C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,7.747,0.0000864006,EXAC_AMR_AF,OTOA
388121,16:21716652:G>C,NM_144672.3:c.1104+39G>C,\N,\N,11/27,Unknown significance,\N,intron_variant,2.557,0.000232558,EVS_EA_AF,OTOA
388122,16:21716719:G>T,NM_144672.3:c.1104+106G>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.617,0.001,1KG_EUR_AF,OTOA
388123,16:21716722:G>A,NM_144672.3:c.1104+109G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.281,\N,\N,OTOA
388124,16:21716779:C>T,NM_144672.3:c.1104+166C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,2.335,\N,\N,OTOA
388125,16:21716782:A>C,NM_144672.3:c.1104+169A>C,\N,\N,11/27,Unknown significance,\N,intron_variant,2.304,\N,\N,OTOA
388126,16:21716824:C>G,NM_144672.3:c.1104+211C>G,\N,\N,11/27,Unknown significance,\N,intron_variant,2.411,\N,\N,OTOA
388127,16:21716835:C>G,NM_144672.3:c.1104+222C>G,\N,\N,11/27,Unknown significance,\N,intron_variant,10.03,0.002,1KG_EAS_AF,OTOA
388128,16:21716850:G>A,NM_144672.3:c.1104+237G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.442,\N,\N,OTOA
388129,16:21716859:G>A,NM_144672.3:c.1104+246G>A,\N,\N,11/27,Benign,\N,intron_variant,0.313,0.0685,1KG_SAS_AF,OTOA
388130,16:21716863:G>T,NM_144672.3:c.1104+250G>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.79,0.001,1KG_EAS_AF,OTOA
388131,16:21716883:C>T,NM_144672.3:c.1104+270C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.581,0.004,1KG_EAS_AF,OTOA
388132,16:21716901:T>A,NM_144672.3:c.1104+288T>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.527,\N,\N,OTOA
388133,16:21716903:G>A,NM_144672.3:c.1104+290G>A,\N,\N,11/27,Benign,\N,intron_variant,0.52,0.0112,1KG_SAS_AF,OTOA
388134,16:21716909:T>A,NM_144672.3:c.1104+296T>A,\N,\N,11/27,Unknown significance,\N,intron_variant,4.489,0.0014,1KG_AMR_AF,OTOA
388135,16:21716918:G>A,NM_144672.3:c.1104+305G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,2.207,\N,\N,OTOA
388136,16:21716946:C>T,NM_144672.3:c.1104+333C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.726,\N,\N,OTOA
388137,16:21716984:AT>A,NM_144672.3:c.1104+372del,\N,\N,11/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388138,16:21716991:G>C,NM_144672.3:c.1104+378G>C,\N,\N,11/27,Unknown significance,\N,intron_variant,2.158,0.001,1KG_EAS_AF,OTOA
388139,16:21717000:G>T,NM_144672.3:c.1104+387G>T,\N,\N,11/27,Benign,\N,intron_variant,0.574,0.0053,1KG_AFR_AF,OTOA
388140,16:21717001:T>A,NM_144672.3:c.1104+388T>A,\N,\N,11/27,Unknown significance,\N,intron_variant,6.248,\N,\N,OTOA
388141,16:21717026:G>A,NM_144672.3:c.1104+413G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,6.827,\N,\N,OTOA
388142,16:21717058:A>G,NM_144672.3:c.1104+445A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,2.292,\N,\N,OTOA
388143,16:21717074:G>A,NM_144672.3:c.1104+461G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.901,0.0008,1KG_AFR_AF,OTOA
388144,16:21717080:C>T,NM_144672.3:c.1104+467C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,2.277,\N,\N,OTOA
388145,16:21717083:G>T,NM_144672.3:c.1104+470G>T,\N,\N,11/27,Benign,\N,intron_variant,0.569,0.0595,1KG_EAS_AF,OTOA
388146,16:21717119:G>C,NM_144672.3:c.1104+506G>C,\N,\N,11/27,Unknown significance,\N,intron_variant,0.253,\N,\N,OTOA
388147,16:21717120:C>T,NM_144672.3:c.1104+507C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.052,0.001,1KG_EAS_AF,OTOA
388148,16:21717121:G>A,NM_144672.3:c.1104+508G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.009,\N,\N,OTOA
388149,16:21717133:G>T,NM_144672.3:c.1104+520G>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.025,\N,\N,OTOA
388150,16:21717134:C>T,NM_144672.3:c.1104+521C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,2.693,0.001,1KG_SAS_AF,OTOA
388151,16:21717203:C>T,NM_144672.3:c.1104+590C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.432,\N,\N,OTOA
388152,16:21717204:G>A,NM_144672.3:c.1104+591G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.277,\N,\N,OTOA
388153,16:21717264:G>A,NM_144672.3:c.1104+651G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.772,\N,\N,OTOA
388154,16:21717264:GA>G,NM_144672.3:c.1104+663del,\N,\N,11/27,Unknown significance,\N,intron_variant,0.029,\N,\N,OTOA
388155,16:21717265:A>G,NM_144672.3:c.1104+652A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,0.086,\N,\N,OTOA
388156,16:21717284:G>C,NM_144672.3:c.1104+671G>C,\N,\N,11/27,Unknown significance,\N,intron_variant,0.678,0.001,1KG_SAS_AF,OTOA
388157,16:21717294:C>T,NM_144672.3:c.1104+681C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,5.876,\N,\N,OTOA
388158,16:21717307:AG>A,NM_144672.3:c.1104+696del,\N,\N,11/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388159,16:21717308:G>A,NM_144672.3:c.1104+695G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,7.146,0.0023,1KG_AFR_AF,OTOA
388160,16:21717317:A>G,NM_144672.3:c.1104+704A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,7.224,0.001,1KG_EAS_AF,OTOA
388161,16:21717325:C>T,NM_144672.3:c.1104+712C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,3.552,\N,\N,OTOA
388162,16:21717339:A>G,NM_144672.3:c.1104+726A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,6.649,0.001,1KG_SAS_AF,OTOA
388163,16:21717377:C>G,NM_144672.3:c.1104+764C>G,\N,\N,11/27,Benign,\N,intron_variant,2.621,0.0072,1KG_SAS_AF,OTOA
388164,16:21717383:T>C,NM_144672.3:c.1104+770T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,1.269,0.0014,1KG_AMR_AF,OTOA
388165,16:21717419:A>C,NM_144672.3:c.1104+806A>C,\N,\N,11/27,Unknown significance,\N,intron_variant,0.599,\N,\N,OTOA
388166,16:21717420:C>CAG,NM_144672.3:c.1104+809_1104+810dup,\N,\N,11/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388167,16:21717420:CAG>C,NM_144672.3:c.1104+809_1104+810del,\N,\N,11/27,Benign,\N,intron_variant,4.721,0.2602,1KG_AFR_AF,OTOA
388168,16:21717439:A>C,NM_144672.3:c.1104+826A>C,\N,\N,11/27,Unknown significance,\N,intron_variant,0.44,\N,\N,OTOA
388169,16:21717447:T>C,NM_144672.3:c.1104+834T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,1.457,0.004,1KG_EAS_AF,OTOA
388170,16:21717450:G>A,NM_144672.3:c.1104+837G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.02,0.0008,1KG_AFR_AF,OTOA
388171,16:21717451:A>G,NM_144672.3:c.1104+838A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,1.967,\N,\N,OTOA
388172,16:21717466:A>C,NM_144672.3:c.1104+853A>C,\N,\N,11/27,Unknown significance,\N,intron_variant,0.057,0.001,1KG_EAS_AF,OTOA
388173,16:21717480:G>T,NM_144672.3:c.1104+867G>T,\N,\N,11/27,Unknown significance,\N,intron_variant,2.14,0.0014,1KG_AMR_AF,OTOA
388174,16:21717482:T>C,NM_144672.3:c.1104+869T>C,\N,\N,11/27,Benign,\N,intron_variant,1.798,0.0446,1KG_AFR_AF,OTOA
388175,16:21717511:C>G,NM_144672.3:c.1104+898C>G,\N,\N,11/27,Unknown significance,\N,intron_variant,2.201,\N,\N,OTOA
388176,16:21717533:C>T,NM_144672.3:c.1104+920C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,2.884,0.002,1KG_SAS_AF,OTOA
388177,16:21717652:G>A,NM_144672.3:c.1104+1039G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,3.897,\N,\N,OTOA
388178,16:21717678:G>A,NM_144672.3:c.1104+1065G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.672,0.001,1KG_SAS_AF,OTOA
388179,16:21717714:T>G,NM_144672.3:c.1104+1101T>G,\N,\N,11/27,Unknown significance,\N,intron_variant,3.177,\N,\N,OTOA
388180,16:21717733:C>A,NM_144672.3:c.1104+1120C>A,\N,\N,11/27,Unknown significance,\N,intron_variant,10.93,0.001,1KG_EAS_AF,OTOA
388181,16:21717902:T>G,NM_144672.3:c.1104+1289T>G,\N,\N,11/27,Unknown significance,\N,intron_variant,1.133,0.001,1KG_EUR_AF,OTOA
388182,16:21717921:C>A,NM_144672.3:c.1104+1308C>A,\N,\N,11/27,Unknown significance,\N,intron_variant,4.531,0,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,OTOA
388183,16:21717958:C>T,NM_144672.3:c.1104+1345C>T,\N,\N,11/27,Benign,\N,intron_variant,3.464,0.0965,1KG_AMR_AF,OTOA
388184,16:21718007:C>T,NM_144672.3:c.1104+1394C>T,\N,\N,11/27,Benign,\N,intron_variant,2.034,0.0938,1KG_AFR_AF,OTOA
388185,16:21718008:G>A,NM_144672.3:c.1104+1395G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,2.685,\N,\N,OTOA
388186,16:21718033:A>G,NM_144672.3:c.1104+1420A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,1.663,\N,\N,OTOA
388187,16:21718084:A>G,NM_144672.3:c.1104+1471A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,0.303,0.0008,1KG_AFR_AF,OTOA
388188,16:21718095:A>C,NM_144672.3:c.1104+1482A>C,\N,\N,11/27,Unknown significance,\N,intron_variant,1.632,0.0038,1KG_AFR_AF,OTOA
388189,16:21718100:C>G,NM_144672.3:c.1104+1487C>G,\N,\N,11/27,Unknown significance,\N,intron_variant,2.04,\N,\N,OTOA
388190,16:21718123:C>T,NM_144672.3:c.1104+1510C>T,\N,\N,11/27,Benign,\N,intron_variant,6.012,0.0129,1KG_AFR_AF,OTOA
388191,16:21718144:CT>C,NM_144672.3:c.1104+1546del,\N,\N,11/27,Unknown significance,\N,intron_variant,3.031,\N,\N,OTOA
388192,16:21718144:CTT>C,NM_144672.3:c.1104+1545_1104+1546del,\N,\N,11/27,Benign,\N,intron_variant,3.052,0.1141,1KG_EAS_AF,OTOA
388193,16:21718146:T>C,NM_144672.3:c.1104+1533T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,0.405,\N,\N,OTOA
388194,16:21718160:A>T,NM_144672.3:c.1104+1547A>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.634,\N,\N,OTOA
388195,16:21718169:A>AT,NM_144672.3:c.1104+1571dup,\N,\N,11/27,Benign,\N,intron_variant,0.051,0.3926,1KG_EUR_AF,OTOA
388196,16:21718169:A>T,NM_144672.3:c.1104+1556A>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.289,\N,\N,OTOA
388197,16:21718253:C>T,NM_144672.3:c.1104+1640C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.986,\N,\N,OTOA
388198,16:21718254:G>A,NM_144672.3:c.1104+1641G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.465,\N,\N,OTOA
388199,16:21718262:G>A,NM_144672.3:c.1104+1649G>A,\N,\N,11/27,Benign,\N,intron_variant,2.166,0.0595,1KG_EAS_AF,OTOA
388200,16:21718283:G>A,NM_144672.3:c.1104+1670G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.547,0.0014,1KG_AMR_AF,OTOA
388201,16:21718291:C>T,NM_144672.3:c.1104+1678C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.16,\N,\N,OTOA
388202,16:21718325:C>T,NM_144672.3:c.1104+1712C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.459,0.0008,1KG_AFR_AF,OTOA
388203,16:21718346:G>A,NM_144672.3:c.1104+1733G>A,\N,\N,11/27,Benign,\N,intron_variant,0.825,0.0408,1KG_AFR_AF,OTOA
388204,16:21718378:G>A,NM_144672.3:c.1104+1765G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,3.463,\N,\N,OTOA
388205,16:21718416:C>A,NM_144672.3:c.1104+1803C>A,\N,\N,11/27,Unknown significance,\N,intron_variant,9.736,\N,\N,OTOA
388206,16:21718466:G>A,NM_144672.3:c.1104+1853G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.006,0.0008,1KG_AFR_AF,OTOA
388207,16:21718522:C>T,NM_144672.3:c.1104+1909C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,2.245,0.0014,1KG_AMR_AF,OTOA
388208,16:21718567:A>G,NM_144672.3:c.1104+1954A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,5.595,\N,\N,OTOA
388209,16:21718608:G>T,NM_144672.3:c.1104+1995G>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.175,0.001,1KG_EAS_AF,OTOA
388210,16:21718630:C>T,NM_144672.3:c.1104+2017C>T,\N,\N,11/27,Benign,\N,intron_variant,2.487,0.0734,1KG_AFR_AF,OTOA
388211,16:21718638:C>A,NM_144672.3:c.1104+2025C>A,\N,\N,11/27,Benign,\N,intron_variant,4.516,0.0526,1KG_EAS_AF,OTOA
388212,16:21718702:C>A,NM_144672.3:c.1104+2089C>A,\N,\N,11/27,Unknown significance,\N,intron_variant,6.153,\N,\N,OTOA
388213,16:21718713:A>T,NM_144672.3:c.1104+2100A>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.623,0.0014,1KG_AMR_AF,OTOA
388214,16:21718714:C>T,NM_144672.3:c.1104+2101C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,3.512,0.001,1KG_SAS_AF,OTOA
388215,16:21718769:G>A,NM_144672.3:c.1104+2156G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,4.394,0.003,1KG_EAS_AF,OTOA
388216,16:21718784:A>G,NM_144672.3:c.1104+2171A>G,\N,\N,11/27,Benign,\N,intron_variant,4.115,0.0536,1KG_EAS_AF,OTOA
388217,16:21718787:T>G,NM_144672.3:c.1104+2174T>G,\N,\N,11/27,Unknown significance,\N,intron_variant,5.687,\N,\N,OTOA
388218,16:21718794:C>T,NM_144672.3:c.1104+2181C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,2.727,0.001,1KG_EAS_AF|1KG_EUR_AF,OTOA
388219,16:21718795:G>A,NM_144672.3:c.1104+2182G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.255,\N,\N,OTOA
388220,16:21718835:G>A,NM_144672.3:c.1104+2222G>A,\N,\N,11/27,Benign,\N,intron_variant,7.375,0.0069,1KG_EAS_AF,OTOA
388221,16:21718857:C>T,NM_144672.3:c.1104+2244C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,7.813,0.001,1KG_SAS_AF,OTOA
388222,16:21718879:C>T,NM_144672.3:c.1104+2266C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,4.68,\N,\N,OTOA
388223,16:21718883:C>T,NM_144672.3:c.1104+2270C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,3.34,\N,\N,OTOA
388224,16:21718902:C>A,NM_144672.3:c.1104+2289C>A,\N,\N,11/27,Unknown significance,\N,intron_variant,4.484,0.002,1KG_EAS_AF,OTOA
388225,16:21718914:T>TTTTC,NM_144672.3:c.1105-2233_1105-2230dup,\N,\N,11/27,Unknown significance,\N,intron_variant,1.636,\N,\N,OTOA
388226,16:21718914:TTTTC>T,NM_144672.3:c.1105-2233_1105-2230del,\N,\N,11/27,Unknown significance,\N,intron_variant,4.46,\N,\N,OTOA
388227,16:21718948:TTCTTTCTTTCTTTCTTTCTTTCTTTCTTTC>T,NM_144672.3:c.1105-2249_1105-2220del,\N,\N,11/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388228,16:21718960:TTCTTTCTTTCTTTCTTTC>T,NM_144672.3:c.1105-2237_1105-2220del,\N,\N,11/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388229,16:21718964:TTCTTTCTTTCTTTC>T,NM_144672.3:c.1105-2233_1105-2220del,\N,\N,11/27,Unknown significance,\N,intron_variant,0.357,\N,\N,OTOA
388230,16:21718972:TTCTTTC>T,NM_144672.3:c.1105-2229_1105-2224del,\N,\N,11/27,Unknown significance,\N,intron_variant,0.576,\N,\N,OTOA
388231,16:21718976:T>C,NM_144672.3:c.1105-2233T>C,\N,\N,11/27,Benign,\N,intron_variant,0.409,0.0234,1KG_AFR_AF,OTOA
388232,16:21718976:TTC>T,NM_144672.3:c.1105-2229_1105-2228del,\N,\N,11/27,Unknown significance,\N,intron_variant,0.44,\N,\N,OTOA
388233,16:21718986:T>G,NM_144672.3:c.1105-2223T>G,\N,\N,11/27,Unknown significance,\N,intron_variant,0.816,\N,\N,OTOA
388234,16:21718990:C>G,NM_144672.3:c.1105-2219C>G,\N,\N,11/27,Unknown significance,\N,intron_variant,0.024,\N,\N,OTOA
388235,16:21718998:C>G,NM_144672.3:c.1105-2211C>G,\N,\N,11/27,Unknown significance,\N,intron_variant,0.035,\N,\N,OTOA
388236,16:21719002:C>T,NM_144672.3:c.1105-2207C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.902,\N,\N,OTOA
388237,16:21719034:T>G,NM_144672.3:c.1105-2175T>G,\N,\N,11/27,Benign,\N,intron_variant,0.77,0.0102,1KG_SAS_AF,OTOA
388238,16:21719048:ACTCT>A,NM_144672.3:c.1105-2154_1105-2151del,\N,\N,11/27,Unknown significance,\N,intron_variant,0.817,\N,\N,OTOA
388239,16:21719055:C>CTCTT,NM_144672.3:c.1105-2143_1105-2140dup,\N,\N,11/27,Unknown significance,\N,intron_variant,0.49,\N,\N,OTOA
388240,16:21719055:C>T,NM_144672.3:c.1105-2154C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.735,\N,\N,OTOA
388241,16:21719055:CTCTT>C,NM_144672.3:c.1105-2143_1105-2140del,\N,\N,11/27,Unknown significance,\N,intron_variant,1.271,\N,\N,OTOA
388242,16:21719093:TC>T,NM_144672.3:c.1105-2107del,\N,\N,11/27,Benign,\N,intron_variant,1.421,0.2728,1KG_EAS_AF,OTOA
388243,16:21719148:G>A,NM_144672.3:c.1105-2061G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.049,\N,\N,OTOA
388244,16:21719180:A>G,NM_144672.3:c.1105-2029A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,3.949,\N,\N,OTOA
388245,16:21719257:G>A,NM_144672.3:c.1105-1952G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,5.374,0.0008,1KG_AFR_AF,OTOA
388246,16:21719304:G>A,NM_144672.3:c.1105-1905G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.598,\N,\N,OTOA
388247,16:21719314:C>T,NM_144672.3:c.1105-1895C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,4.067,0.0014,1KG_AMR_AF,OTOA
388248,16:21719315:A>G,NM_144672.3:c.1105-1894A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,3.776,\N,\N,OTOA
388249,16:21719330:T>C,NM_144672.3:c.1105-1879T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,1.582,\N,\N,OTOA
388250,16:21719392:G>A,NM_144672.3:c.1105-1817G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.527,\N,\N,OTOA
388251,16:21719403:C>T,NM_144672.3:c.1105-1806C>T,\N,\N,11/27,Benign,\N,intron_variant,0.117,0.0526,1KG_EAS_AF,OTOA
388252,16:21719407:C>T,NM_144672.3:c.1105-1802C>T,\N,\N,11/27,Benign,\N,intron_variant,1.361,0.0083,1KG_AFR_AF,OTOA
388253,16:21719408:G>A,NM_144672.3:c.1105-1801G>A,\N,\N,11/27,Benign,\N,intron_variant,0.235,0.2505,1KG_SAS_AF,OTOA
388254,16:21719502:T>C,NM_144672.3:c.1105-1707T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,3.447,0.003,1KG_EAS_AF,OTOA
388255,16:21719521:G>A,NM_144672.3:c.1105-1688G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.409,0.0041,1KG_SAS_AF,OTOA
388256,16:21719540:G>A,NM_144672.3:c.1105-1669G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,16.04,0.0015,1KG_AFR_AF,OTOA
388257,16:21719563:G>A,NM_144672.3:c.1105-1646G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,11.17,\N,\N,OTOA
388258,16:21719585:G>A,NM_144672.3:c.1105-1624G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.201,0.0015,1KG_AFR_AF,OTOA
388259,16:21719610:C>T,NM_144672.3:c.1105-1599C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,2.024,0.001,1KG_EAS_AF,OTOA
388260,16:21719649:C>T,NM_144672.3:c.1105-1560C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.474,\N,\N,OTOA
388261,16:21719650:G>A,NM_144672.3:c.1105-1559G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.743,0.001,1KG_EAS_AF,OTOA
388262,16:21719681:C>G,NM_144672.3:c.1105-1528C>G,\N,\N,11/27,Unknown significance,\N,intron_variant,1.016,0.0008,1KG_AFR_AF,OTOA
388263,16:21719682:G>A,NM_144672.3:c.1105-1527G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.626,0.001,1KG_SAS_AF,OTOA
388264,16:21719747:G>T,NM_144672.3:c.1105-1462G>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.49,0.001,1KG_EAS_AF,OTOA
388265,16:21719752:C>A,NM_144672.3:c.1105-1457C>A,\N,\N,11/27,Unknown significance,\N,intron_variant,4.081,\N,\N,OTOA
388266,16:21719816:G>A,NM_144672.3:c.1105-1393G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,10.91,\N,\N,OTOA
388267,16:21719820:G>A,NM_144672.3:c.1105-1389G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,9.871,0.001,1KG_SAS_AF,OTOA
388268,16:21719840:T>A,NM_144672.3:c.1105-1369T>A,\N,\N,11/27,Benign,\N,intron_variant,7.037,0.0596,1KG_EUR_AF,OTOA
388269,16:21719878:G>T,NM_144672.3:c.1105-1331G>T,\N,\N,11/27,Benign,\N,intron_variant,4.232,0.0072,1KG_SAS_AF,OTOA
388270,16:21719900:G>A,NM_144672.3:c.1105-1309G>A,\N,\N,11/27,Benign,\N,intron_variant,4.68,0.1111,1KG_EAS_AF,OTOA
388271,16:21719922:C>T,NM_144672.3:c.1105-1287C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,4.878,\N,\N,OTOA
388272,16:21719936:A>G,NM_144672.3:c.1105-1273A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,1.028,0.0014,1KG_AMR_AF,OTOA
388273,16:21719953:T>C,NM_144672.3:c.1105-1256T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,0.85,\N,\N,OTOA
388274,16:21719975:T>TA,NM_144672.3:c.1105-1233dup,\N,\N,11/27,Benign,\N,intron_variant,0.822,0.0076,1KG_AFR_AF,OTOA
388275,16:21719991:T>C,NM_144672.3:c.1105-1218T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,3.128,0.001,1KG_SAS_AF,OTOA
388276,16:21719995:A>G,NM_144672.3:c.1105-1214A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,3.639,\N,\N,OTOA
388277,16:21719996:C>A,NM_144672.3:c.1105-1213C>A,\N,\N,11/27,Unknown significance,\N,intron_variant,6.733,\N,\N,OTOA
388278,16:21720009:T>C,NM_144672.3:c.1105-1200T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,1.501,0.0008,1KG_AFR_AF,OTOA
388279,16:21720023:G>GC,NM_144672.3:c.1105-1180dup,\N,\N,11/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388280,16:21720029:C>A,NM_144672.3:c.1105-1180C>A,\N,\N,11/27,Unknown significance,\N,intron_variant,9.898,\N,\N,OTOA
388281,16:21720029:C>G,NM_144672.3:c.1105-1180C>G,\N,\N,11/27,Benign,\N,intron_variant,8.094,0.0136,1KG_AFR_AF,OTOA
388282,16:21720040:T>C,NM_144672.3:c.1105-1169T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,9.656,0.001,1KG_EUR_AF,OTOA
388283,16:21720053:A>C,NM_144672.3:c.1105-1156A>C,\N,\N,11/27,Unknown significance,\N,intron_variant,0.401,\N,\N,OTOA
388284,16:21720084:TAC>T,NM_144672.3:c.1105-1124_1105-1123del,\N,\N,11/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388285,16:21720108:T>C,NM_144672.3:c.1105-1101T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,8.702,0.0015,1KG_AFR_AF,OTOA
388286,16:21720127:T>G,NM_144672.3:c.1105-1082T>G,\N,\N,11/27,Unknown significance,\N,intron_variant,0.993,0.0008,1KG_AFR_AF,OTOA
388287,16:21720144:C>A,NM_144672.3:c.1105-1065C>A,\N,\N,11/27,Unknown significance,\N,intron_variant,4.886,0.0008,1KG_AFR_AF,OTOA
388288,16:21720147:A>G,NM_144672.3:c.1105-1062A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,1.557,0.0015,1KG_AFR_AF,OTOA
388289,16:21720153:T>G,NM_144672.3:c.1105-1056T>G,\N,\N,11/27,Unknown significance,\N,intron_variant,4.575,0.001,1KG_EUR_AF,OTOA
388290,16:21720200:C>T,NM_144672.3:c.1105-1009C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,5.799,0.001,1KG_EAS_AF,OTOA
388291,16:21720203:T>C,NM_144672.3:c.1105-1006T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,1.092,\N,\N,OTOA
388292,16:21720211:C>T,NM_144672.3:c.1105-998C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,3.44,0.001,1KG_SAS_AF,OTOA
388293,16:21720248:A>G,NM_144672.3:c.1105-961A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,9.594,\N,\N,OTOA
388294,16:21720265:CAA>C,NM_144672.3:c.1105-942_1105-941del,\N,\N,11/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388295,16:21720275:C>T,NM_144672.3:c.1105-934C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,3.493,\N,\N,OTOA
388296,16:21720299:A>G,NM_144672.3:c.1105-910A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,4.76,0.002,1KG_EUR_AF,OTOA
388297,16:21720313:T>G,NM_144672.3:c.1105-896T>G,\N,\N,11/27,Unknown significance,\N,intron_variant,7.365,\N,\N,OTOA
388298,16:21720319:T>C,NM_144672.3:c.1105-890T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,0.813,\N,\N,OTOA
388299,16:21720341:A>G,NM_144672.3:c.1105-868A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,3.007,\N,\N,OTOA
388300,16:21720342:G>A,NM_144672.3:c.1105-867G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,2.858,\N,\N,OTOA
388301,16:21720361:G>A,NM_144672.3:c.1105-848G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,4.489,\N,\N,OTOA
388302,16:21720385:T>C,NM_144672.3:c.1105-824T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,10.34,\N,\N,OTOA
388303,16:21720403:A>G,NM_144672.3:c.1105-806A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,3.052,\N,\N,OTOA
388304,16:21720448:T>C,NM_144672.3:c.1105-761T>C,\N,\N,11/27,Unknown significance,\N,intron_variant,4.081,\N,\N,OTOA
388305,16:21720503:A>T,NM_144672.3:c.1105-706A>T,\N,\N,11/27,Unknown significance,\N,intron_variant,3.545,0.002,1KG_EAS_AF,OTOA
388306,16:21720537:T>G,NM_144672.3:c.1105-672T>G,\N,\N,11/27,Benign,\N,intron_variant,3.397,0.1121,1KG_EAS_AF,OTOA
388307,16:21720648:T>G,NM_144672.3:c.1105-561T>G,\N,\N,11/27,Unknown significance,\N,intron_variant,0.927,0.002,1KG_EAS_AF,OTOA
388308,16:21720662:C>T,NM_144672.3:c.1105-547C>T,\N,\N,11/27,Benign,\N,intron_variant,0.121,0.0734,1KG_AFR_AF,OTOA
388309,16:21720673:G>A,NM_144672.3:c.1105-536G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.973,0.001,1KG_SAS_AF,OTOA
388310,16:21720676:A>C,NM_144672.3:c.1105-533A>C,\N,\N,11/27,Unknown significance,\N,intron_variant,0.697,0.001,1KG_EUR_AF,OTOA
388311,16:21720690:G>A,NM_144672.3:c.1105-519G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.598,0.0015,1KG_AFR_AF,OTOA
388312,16:21720714:C>T,NM_144672.3:c.1105-495C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.696,0.0014,1KG_AMR_AF,OTOA
388313,16:21720719:A>G,NM_144672.3:c.1105-490A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,0.369,\N,\N,OTOA
388314,16:21720728:C>A,NM_144672.3:c.1105-481C>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.587,0.0014,1KG_AMR_AF,OTOA
388315,16:21720748:C>CT,NM_144672.3:c.1105-460dup,\N,\N,11/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388316,16:21720750:C>T,NM_144672.3:c.1105-459C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.769,0.003,1KG_EAS_AF,OTOA
388317,16:21720759:GA>G,NM_144672.3:c.1105-438del,\N,\N,11/27,Unknown significance,\N,intron_variant,0.02,\N,\N,OTOA
388318,16:21720760:A>G,NM_144672.3:c.1105-449A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,0.057,\N,\N,OTOA
388319,16:21720784:C>T,NM_144672.3:c.1105-425C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,15.2,0.0015,1KG_AFR_AF,OTOA
388320,16:21720799:C>T,NM_144672.3:c.1105-410C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,7.919,0.001,1KG_EUR_AF,OTOA
388321,16:21720869:C>T,NM_144672.3:c.1105-340C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,4.224,0.002,1KG_EAS_AF,OTOA
388322,16:21720888:A>G,NM_144672.3:c.1105-321A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,3.357,0.001,1KG_SAS_AF,OTOA
388323,16:21720934:G>A,NM_144672.3:c.1105-275G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,9.493,\N,\N,OTOA
388324,16:21721005:A>G,NM_144672.3:c.1105-204A>G,\N,\N,11/27,Unknown significance,\N,intron_variant,4.727,0.001,1KG_SAS_AF,OTOA
388325,16:21721014:A>G,NM_144672.3:c.1105-195A>G,\N,\N,11/27,Benign,\N,intron_variant,6.276,0.1121,1KG_EAS_AF,OTOA
388326,16:21721015:G>T,NM_144672.3:c.1105-194G>T,\N,\N,11/27,Unknown significance,\N,intron_variant,0.349,\N,\N,OTOA
388327,16:21721025:C>T,NM_144672.3:c.1105-184C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,4.986,\N,\N,OTOA
388328,16:21721026:C>T,NM_144672.3:c.1105-183C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.154,\N,\N,OTOA
388329,16:21721027:G>A,NM_144672.3:c.1105-182G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,0.92,0.003,1KG_EAS_AF,OTOA
388330,16:21721034:G>T,NM_144672.3:c.1105-175G>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.621,0.001,1KG_SAS_AF,OTOA
388331,16:21721041:T>G,NM_144672.3:c.1105-168T>G,\N,\N,11/27,Unknown significance,\N,intron_variant,4.003,\N,\N,OTOA
388332,16:21721074:C>T,NM_144672.3:c.1105-135C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,1.85,\N,\N,OTOA
388333,16:21721075:G>A,NM_144672.3:c.1105-134G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.773,0.0023,1KG_AFR_AF,OTOA
388334,16:21721107:G>A,NM_144672.3:c.1105-102G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,3.136,0.0014,1KG_AMR_AF,OTOA
388335,16:21721163:C>G,NM_144672.3:c.1105-46C>G,\N,\N,11/27,Unknown significance,\N,intron_variant,0.615,0.001,1KG_EAS_AF,OTOA
388336,16:21721164:G>A,NM_144672.3:c.1105-45G>A,\N,\N,11/27,Unknown significance,\N,intron_variant,1.353,0.000227376,EVS_AA_AF,OTOA
388337,16:21721167:C>T,NM_144672.3:c.1105-42C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,5.653,0.0000300264,EXAC_NFE_AF,OTOA
388338,16:21721173:C>T,NM_144672.3:c.1105-36C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,5.128,0.000227376,EVS_AA_AF,OTOA
388339,16:21721181:C>T,NM_144672.3:c.1105-28C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,3,0.00162021,EXAC_NFE_AF,OTOA
388340,16:21721185:C>T,NM_144672.3:c.1105-24C>T,\N,\N,11/27,Unknown significance,\N,intron_variant,8.164,0.002,1KG_EUR_AF,OTOA
388341,16:21721192:G>A,NM_144672.3:c.1105-17G>A,\N,\N,11/27,Benign,\N,intron_variant,1.066,0.0446,1KG_AFR_AF,OTOA
388342,16:21721195:TG>T,NM_144672.3:c.1105-13del,\N,\N,11/27,Unknown significance,\N,intron_variant,5.718,0.0000961354,EXAC_AFR_AF,OTOA
388343,16:21721199:C>T,NM_144672.3:c.1105-10C>T,\N,\N,11/27,Likely benign,\N,intron_variant,12.12,\N,\N,OTOA
388344,16:21721208:G>A,NM_144672.3:c.1105-1G>A,\N,\N,11/27,Unknown significance,\N,splice_acceptor_variant,25.3,0.0000149916,EXAC_NFE_AF,OTOA
388345,16:21721213:A>G,NM_144672.3:c.1109A>G,NP_653273.3:p.Lys370Arg,12/28,\N,Unknown significance,\N,missense_variant,24.2,\N,\N,OTOA
388346,16:21721223:C>G,NM_144672.3:c.1119C>G,NP_653273.3:p.Leu373=,12/28,\N,Unknown significance,\N,synonymous_variant,10.17,0.0000605767,EXAC_SAS_AF,OTOA
388347,16:21721223:C>T,NM_144672.3:c.1119C>T,NP_653273.3:p.Leu373=,12/28,\N,Unknown significance,\N,synonymous_variant,12.71,0.000227376,EVS_AA_AF,OTOA
388348,16:21721228:A>ACATTG,NM_144672.3:c.1126_1130dup,NP_653273.3:p.Met378LeufsTer20,12/28,\N,Unknown significance,\N,frameshift_variant,35,\N,\N,OTOA
388349,16:21721229:C>T,NM_144672.3:c.1125C>T,NP_653273.3:p.Asp375=,12/28,\N,Unknown significance,\N,synonymous_variant,13.47,0.0023,1KG_AFR_AF,OTOA
388350,16:21721230:A>G,NM_144672.3:c.1126A>G,NP_653273.3:p.Ile376Val,12/28,\N,Unknown significance,\N,missense_variant,10.89,0.0000149876,EXAC_NFE_AF,OTOA
388351,16:21721234:C>T,NM_144672.3:c.1130C>T,NP_653273.3:p.Ala377Val,12/28,\N,Unknown significance,\N,missense_variant,25.5,0.000116279,EVS_EA_AF,OTOA
388352,16:21721241:G>A,NM_144672.3:c.1137G>A,NP_653273.3:p.Glu379=,12/28,\N,Unknown significance,\N,synonymous_variant,11.69,0.0000149867,EXAC_NFE_AF,OTOA
388353,16:21721242:A>G,NM_144672.3:c.1138A>G,NP_653273.3:p.Asn380Asp,12/28,\N,Unknown significance,\N,missense_variant,24,0.0000149867,EXAC_NFE_AF,OTOA
388354,16:21721245:C>G,NM_144672.3:c.1141C>G,NP_653273.3:p.Gln381Glu,12/28,\N,Benign,\N,missense_variant,23.4,0.045,1KG_SAS_AF,OTOA
388355,16:21721247:G>A,NM_144672.3:c.1143G>A,NP_653273.3:p.Gln381=,12/28,\N,Unknown significance,\N,synonymous_variant,10.29,0.0025,OTO_JP_AF,OTOA
388356,16:21721255:A>G,NM_144672.3:c.1151A>G,NP_653273.3:p.Asn384Ser,12/28,\N,Unknown significance,\N,missense_variant,13.14,0.000115821,EXAC_EAS_AF,OTOA
388357,16:21721256:T>C,NM_144672.3:c.1152T>C,NP_653273.3:p.Asn384=,12/28,\N,Unknown significance,\N,synonymous_variant,4.146,0.0000149867,EXAC_NFE_AF,OTOA
388358,16:21721265:G>A,NM_144672.3:c.1161G>A,NP_653273.3:p.Leu387=,12/28,\N,Unknown significance,\N,synonymous_variant,10.77,0.000227376,EVS_AA_AF,OTOA
388359,16:21721270:C>A,NM_144672.3:c.1166C>A,NP_653273.3:p.Ser389Tyr,12/28,\N,Unknown significance,\N,missense_variant,29,0.0000149889,EXAC_NFE_AF,OTOA
388360,16:21721276:C>T,NM_144672.3:c.1172C>T,NP_653273.3:p.Ser391Leu,12/28,\N,Unknown significance,\N,missense_variant,33,0.0000149898,EXAC_NFE_AF,OTOA
388361,16:21721277:G>A,NM_144672.3:c.1173G>A,NP_653273.3:p.Ser391=,12/28,\N,Unknown significance,\N,synonymous_variant,11.86,0.00124976,EXAC_AFR_AF,OTOA
388362,16:21721294:T>G,NM_144672.3:c.1190T>G,NP_653273.3:p.Leu397Trp,12/28,\N,Unknown significance,\N,missense_variant,24,0.000181884,EXAC_SAS_AF,OTOA
388363,16:21721317:C>T,NM_144672.3:c.1213C>T,NP_653273.3:p.Leu405Phe,12/28,\N,Unknown significance,\N,missense_variant,25,0.0000869414,EXAC_AMR_AF,OTOA
388364,16:21721319:C>T,NM_144672.3:c.1215C>T,NP_653273.3:p.Leu405=,12/28,\N,Unknown significance,\N,synonymous_variant,13,0.001,1KG_EUR_AF,OTOA
388365,16:21721323:C>T,NM_144672.3:c.1219C>T,NP_653273.3:p.Pro407Ser,12/28,\N,Likely benign,\N,missense_variant,23,0.000232558,EXAC_EAS_AF,OTOA
388366,16:21721325:C>T,NM_144672.3:c.1221C>T,NP_653273.3:p.Pro407=,12/28,\N,Unknown significance,\N,synonymous_variant,13.81,0.0000150466,EXAC_NFE_AF,OTOA
388367,16:21721326:G>A,NM_144672.3:c.1222G>A,NP_653273.3:p.Glu408Lys,12/28,\N,Unknown significance,\N,missense_variant,22.5,0.000116279,EVS_EA_AF,OTOA
388368,16:21721332:G>A,NM_144672.3:c.1228G>A,NP_653273.3:p.Val410Met,12/28,\N,Unknown significance,\N,missense_variant,27.5,0.0000150652,EXAC_NFE_AF,OTOA
388369,16:21721336:A>G,NM_144672.3:c.1232A>G,NP_653273.3:p.His411Arg,12/28,\N,Unknown significance,\N,missense_variant,11.07,0.0000874738,EXAC_AMR_AF,OTOA
388370,16:21721337:C>T,NM_144672.3:c.1233C>T,NP_653273.3:p.His411=,12/28,\N,Unknown significance,\N,synonymous_variant,11.44,0.0008,1KG_AFR_AF,OTOA
388371,16:21721338:G>A,NM_144672.3:c.1234G>A,NP_653273.3:p.Gly412Arg,12/28,\N,Likely benign,\N,missense_variant,5.579,0.000061267,EXAC_SAS_AF,OTOA
388372,16:21721344:A>G,NM_144672.3:c.1240A>G,NP_653273.3:p.Ile414Val,12/28,\N,Unknown significance,\N,missense_variant,16.38,0.0000301969,EXAC_NFE_AF,OTOA
388373,16:21721353:C>T,NM_001161683.1:c.1012C>T,NP_001155155.1:p.Leu338Phe,8/24,\N,Likely pathogenic,Sensorineural hearing loss| nonsyndromic,missense_variant,28.6,\N,\N,OTOA
388374,16:21721359:C>T,NM_144672.3:c.1255C>T,NP_653273.3:p.Gln419Ter,12/28,\N,Unknown significance,\N,stop_gained,38,0.000117288,EXAC_EAS_AF,OTOA
388375,16:21721363:T>C,NM_144672.3:c.1259T>C,NP_653273.3:p.Val420Ala,12/28,\N,Unknown significance,\N,missense_variant,25.6,0.0000152226,EXAC_NFE_AF,OTOA
388376,16:21721369:G>T,NM_144672.3:c.1265G>T,NP_653273.3:p.Gly422Val,12/28,\N,Unknown significance,\N,missense_variant,28.2,0.001,1KG_EAS_AF,OTOA
388377,16:21721378:A>T,NM_144672.3:c.1274A>T,NP_653273.3:p.Lys425Met,12/28,\N,Likely benign,\N,missense_variant,24.3,0.000100685,EXAC_AFR_AF,OTOA
388378,16:21721388:C>T,NM_144672.3:c.1284C>T,NP_653273.3:p.Val428=,12/28,\N,Unknown significance,\N,synonymous_variant,13.34,\N,\N,OTOA
388379,16:21721392:A>G,NM_144672.3:c.1288A>G,NP_653273.3:p.Ile430Val,12/28,\N,Unknown significance,\N,missense_variant,9.02,0.0000659196,EXAC_SAS_AF,OTOA
388380,16:21721406:A>G,NM_144672.3:c.1302A>G,NP_653273.3:p.Lys434=,12/28,\N,Unknown significance,\N,synonymous_variant,3.786,0.0000173382,EXAC_NFE_AF,OTOA
388381,16:21721419:G>A,NM_170664.2:c.343G>A,NP_733764.1:p.Glu115Lys,3/19,\N,Unknown significance,\N,missense_variant,24.7,0.0000194122,EXAC_NFE_AF,OTOA
388382,16:21721426:T>C,NM_144672.3:c.1320+2T>C,\N,\N,12/27,Pathogenic,Deafness| autosomal recessive,splice_donor_variant,24.2,\N,\N,OTOA
388383,16:21721429:G>C,NM_144672.3:c.1320+5G>C,\N,\N,12/27,Unknown significance,\N,splice_region_variant&intron_variant,13.63,0.000181094,EXAC_EAS_AF,OTOA
388384,16:21721434:A>G,NM_144672.3:c.1320+10A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,13.58,\N,\N,OTOA
388385,16:21721441:A>T,NM_144672.3:c.1320+17A>T,\N,\N,12/27,Unknown significance,\N,intron_variant,3.516,\N,\N,OTOA
388386,16:21721442:A>G,NM_144672.3:c.1320+18A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,3.17,0.000116279,EVS_EA_AF,OTOA
388387,16:21721443:C>G,NM_144672.3:c.1320+19C>G,\N,\N,12/27,Unknown significance,\N,intron_variant,1.668,0,EXAC_ALL_AF|EXAC_AFR_AF|EXAC_AMR_AF|EXAC_EAS_AF|EXAC_FIN_AF|EXAC_NFE_AF|EXAC_OTH_AF|EXAC_SAS_AF,OTOA
388388,16:21721443:C>T,NM_144672.3:c.1320+19C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.423,0.002,1KG_EUR_AF,OTOA
388389,16:21721455:C>T,NM_144672.3:c.1320+31C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.514,0.000707714,EXAC_AMR_AF,OTOA
388390,16:21721463:A>G,NM_144672.3:c.1320+39A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,4.012,0,EXAC_ALL_AF|EXAC_AFR_AF|EXAC_AMR_AF|EXAC_EAS_AF|EXAC_FIN_AF|EXAC_NFE_AF|EXAC_OTH_AF|EXAC_SAS_AF,OTOA
388391,16:21721463:A>T,NM_144672.3:c.1320+39A>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.483,0.0000548306,EXAC_NFE_AF,OTOA
388392,16:21721485:G>T,NM_144672.3:c.1320+61G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.697,0.001,1KG_EUR_AF,OTOA
388393,16:21721493:G>T,NM_144672.3:c.1320+69G>T,\N,\N,12/27,Benign,\N,intron_variant,0.566,0.0446,1KG_AFR_AF,OTOA
388394,16:21721519:T>A,NM_144672.3:c.1320+95T>A,\N,\N,12/27,Unknown significance,\N,intron_variant,6.886,\N,\N,OTOA
388395,16:21721522:C>T,NM_144672.3:c.1320+98C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.374,\N,\N,OTOA
388396,16:21721523:G>A,NM_144672.3:c.1320+99G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.419,\N,\N,OTOA
388397,16:21721605:G>A,NM_144672.3:c.1320+181G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.716,\N,\N,OTOA
388398,16:21721625:G>T,NM_144672.3:c.1320+201G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.721,0.001,1KG_EUR_AF,OTOA
388399,16:21721636:C>T,NM_144672.3:c.1320+212C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,5.446,0.0014,1KG_AMR_AF,OTOA
388400,16:21721668:GAGCA>G,NM_144672.3:c.1320+248_1320+251del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388401,16:21721670:G>A,NM_144672.3:c.1320+246G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.616,\N,\N,OTOA
388402,16:21721689:G>A,NM_144672.3:c.1320+265G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.232,\N,\N,OTOA
388403,16:21721770:C>A,NM_144672.3:c.1320+346C>A,\N,\N,12/27,Unknown significance,\N,intron_variant,5.667,0.001,1KG_SAS_AF,OTOA
388404,16:21721774:T>C,NM_144672.3:c.1320+350T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.75,0.0015,1KG_AFR_AF,OTOA
388405,16:21721780:G>T,NM_144672.3:c.1320+356G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.003,\N,\N,OTOA
388406,16:21721786:C>A,NM_144672.3:c.1320+362C>A,\N,\N,12/27,Unknown significance,\N,intron_variant,6.852,0.001,1KG_SAS_AF,OTOA
388407,16:21721793:A>G,NM_144672.3:c.1320+369A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,3.357,\N,\N,OTOA
388408,16:21721810:G>A,NM_144672.3:c.1320+386G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.403,0.002,1KG_SAS_AF,OTOA
388409,16:21721842:C>T,NM_144672.3:c.1320+418C>T,\N,\N,12/27,Benign,\N,intron_variant,2.592,0.0734,1KG_AFR_AF,OTOA
388410,16:21721845:AAATATTT>A,NM_144672.3:c.1320+425_1320+431del,\N,\N,12/27,Unknown significance,\N,intron_variant,8.883,\N,\N,OTOA
388411,16:21721975:G>A,NM_144672.3:c.1320+551G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,3.681,\N,\N,OTOA
388412,16:21721975:G>T,NM_144672.3:c.1320+551G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.216,\N,\N,OTOA
388413,16:21721986:T>G,NM_144672.3:c.1320+562T>G,\N,\N,12/27,Unknown significance,\N,intron_variant,0.148,\N,\N,OTOA
388414,16:21722031:A>G,NM_144672.3:c.1320+607A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,1.343,0.0008,1KG_AFR_AF,OTOA
388415,16:21722103:C>T,NM_144672.3:c.1320+679C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.149,\N,\N,OTOA
388416,16:21722110:C>T,NM_144672.3:c.1320+686C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.556,\N,\N,OTOA
388417,16:21722153:G>A,NM_144672.3:c.1320+729G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.055,\N,\N,OTOA
388418,16:21722167:T>C,NM_144672.3:c.1320+743T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,6.298,0.0014,1KG_AMR_AF,OTOA
388419,16:21722184:C>T,NM_144672.3:c.1320+760C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.098,\N,\N,OTOA
388420,16:21722185:G>A,NM_144672.3:c.1320+761G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.029,0.001,1KG_EUR_AF,OTOA
388421,16:21722188:G>A,NM_144672.3:c.1320+764G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.29,\N,\N,OTOA
388422,16:21722189:T>A,NM_144672.3:c.1320+765T>A,\N,\N,12/27,Unknown significance,\N,intron_variant,3.921,\N,\N,OTOA
388423,16:21722197:G>A,NM_144672.3:c.1320+773G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,2.201,\N,\N,OTOA
388424,16:21722362:C>T,NM_144672.3:c.1320+938C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,7.2,0.0014,1KG_AMR_AF,OTOA
388425,16:21722400:G>T,NM_144672.3:c.1320+976G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.441,\N,\N,OTOA
388426,16:21722406:A>G,NM_144672.3:c.1320+982A>G,\N,\N,12/27,Benign,\N,intron_variant,0.74,0.0298,1KG_EUR_AF,OTOA
388427,16:21722429:G>A,NM_144672.3:c.1320+1005G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,4.76,0.0008,1KG_AFR_AF,OTOA
388428,16:21722483:G>A,NM_144672.3:c.1320+1059G>A,\N,\N,12/27,Benign,\N,intron_variant,4.145,0.0734,1KG_AFR_AF,OTOA
388429,16:21722549:A>T,NM_144672.3:c.1320+1125A>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.572,\N,\N,OTOA
388430,16:21722552:G>T,NM_144672.3:c.1320+1128G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.043,\N,\N,OTOA
388431,16:21722554:G>A,NM_144672.3:c.1320+1130G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.728,0.003,1KG_AFR_AF,OTOA
388432,16:21722561:G>C,NM_144672.3:c.1320+1137G>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.159,\N,\N,OTOA
388433,16:21722563:C>T,NM_144672.3:c.1320+1139C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,3.869,\N,\N,OTOA
388434,16:21722579:G>A,NM_144672.3:c.1320+1155G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,3.922,0.0045,1KG_AFR_AF,OTOA
388435,16:21722582:A>G,NM_144672.3:c.1320+1158A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,1.457,0.001,1KG_EUR_AF,OTOA
388436,16:21722634:A>G,NM_144672.3:c.1320+1210A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,6.058,0.001,1KG_SAS_AF,OTOA
388437,16:21722709:T>G,NM_144672.3:c.1320+1285T>G,\N,\N,12/27,Unknown significance,\N,intron_variant,2.06,0.001,1KG_SAS_AF,OTOA
388438,16:21722714:A>C,NM_144672.3:c.1320+1290A>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.951,0.001,1KG_SAS_AF,OTOA
388439,16:21722750:G>T,NM_144672.3:c.1320+1326G>T,\N,\N,12/27,Benign,\N,intron_variant,3.636,0.0356,1KG_AFR_AF,OTOA
388440,16:21722782:T>C,NM_144672.3:c.1320+1358T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,1.969,0.0008,1KG_AFR_AF,OTOA
388441,16:21722809:A>G,NM_144672.3:c.1320+1385A>G,\N,\N,12/27,Benign,\N,intron_variant,2.07,0.025,1KG_AFR_AF,OTOA
388442,16:21722812:C>T,NM_144672.3:c.1320+1388C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.92,0.001,1KG_EUR_AF,OTOA
388443,16:21722830:G>A,NM_144672.3:c.1320+1406G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.185,0.001,1KG_EUR_AF,OTOA
388444,16:21722830:G>T,NM_144672.3:c.1320+1406G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.065,\N,\N,OTOA
388445,16:21722857:C>T,NM_144672.3:c.1320+1433C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,3.489,0.0045,1KG_AFR_AF,OTOA
388446,16:21722876:C>T,NM_144672.3:c.1320+1452C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.292,0.003,1KG_AFR_AF,OTOA
388447,16:21722882:C>T,NM_144672.3:c.1320+1458C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.381,0.002,1KG_SAS_AF,OTOA
388448,16:21722914:C>T,NM_144672.3:c.1320+1490C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.202,0.0014,1KG_AMR_AF,OTOA
388449,16:21722943:C>T,NM_144672.3:c.1320+1519C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.275,\N,\N,OTOA
388450,16:21722950:C>T,NM_144672.3:c.1320+1526C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.058,0.0008,1KG_AFR_AF,OTOA
388451,16:21722954:G>A,NM_144672.3:c.1320+1530G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.125,\N,\N,OTOA
388452,16:21722971:G>C,NM_144672.3:c.1320+1547G>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.256,\N,\N,OTOA
388453,16:21722981:G>A,NM_144672.3:c.1320+1557G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,2.079,0.001,1KG_EAS_AF,OTOA
388454,16:21722986:C>T,NM_144672.3:c.1320+1562C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.334,0.001,1KG_SAS_AF,OTOA
388455,16:21722987:G>A,NM_144672.3:c.1320+1563G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.642,\N,\N,OTOA
388456,16:21722999:A>G,NM_144672.3:c.1320+1575A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,3.677,\N,\N,OTOA
388457,16:21723030:C>T,NM_144672.3:c.1320+1606C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.216,\N,\N,OTOA
388458,16:21723031:G>A,NM_144672.3:c.1320+1607G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.128,0.002,1KG_EAS_AF,OTOA
388459,16:21723064:A>G,NM_144672.3:c.1320+1640A>G,\N,\N,12/27,Benign,\N,intron_variant,2.542,0.0112,1KG_SAS_AF,OTOA
388460,16:21723084:G>A,NM_144672.3:c.1320+1660G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.753,0.001,1KG_EUR_AF,OTOA
388461,16:21723200:T>C,NM_144672.3:c.1320+1776T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.3,0.001,1KG_EAS_AF,OTOA
388462,16:21723230:A>G,NM_144672.3:c.1320+1806A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,6.425,0.001,1KG_EUR_AF,OTOA
388463,16:21723263:G>T,NM_144672.3:c.1320+1839G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.112,0.0014,1KG_AMR_AF,OTOA
388464,16:21723273:C>T,NM_144672.3:c.1320+1849C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.871,\N,\N,OTOA
388465,16:21723276:C>T,NM_144672.3:c.1320+1852C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.686,\N,\N,OTOA
388466,16:21723312:T>G,NM_144672.3:c.1320+1888T>G,\N,\N,12/27,Unknown significance,\N,intron_variant,6.67,0.001,1KG_EUR_AF,OTOA
388467,16:21723328:T>C,NM_144672.3:c.1320+1904T>C,\N,\N,12/27,Benign,\N,intron_variant,8.906,0.0734,1KG_AFR_AF,OTOA
388468,16:21723342:A>G,NM_144672.3:c.1320+1918A>G,\N,\N,12/27,Benign,\N,intron_variant,9.038,0.0099,1KG_EUR_AF,OTOA
388469,16:21723348:AT>A,NM_144672.3:c.1320+1928del,\N,\N,12/27,Benign,\N,intron_variant,6.449,0.056,1KG_AFR_AF,OTOA
388470,16:21723393:A>G,NM_144672.3:c.1320+1969A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,2.217,\N,\N,OTOA
388471,16:21723469:G>A,NM_144672.3:c.1320+2045G>A,\N,\N,12/27,Benign,\N,intron_variant,3.021,0.1121,1KG_EAS_AF,OTOA
388472,16:21723473:C>T,NM_144672.3:c.1320+2049C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.86,0.001,1KG_EUR_AF,OTOA
388473,16:21723525:G>A,NM_144672.3:c.1320+2101G>A,\N,\N,12/27,Benign,\N,intron_variant,1.331,0.0099,1KG_EAS_AF,OTOA
388474,16:21723548:C>T,NM_144672.3:c.1320+2124C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.572,\N,\N,OTOA
388475,16:21723549:G>A,NM_144672.3:c.1320+2125G>A,\N,\N,12/27,Benign,\N,intron_variant,0.457,0.0965,1KG_AMR_AF,OTOA
388476,16:21723588:T>C,NM_144672.3:c.1320+2164T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,6.554,0.0008,1KG_AFR_AF,OTOA
388477,16:21723590:G>T,NM_144672.3:c.1320+2166G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,5.349,0.0015,1KG_AFR_AF,OTOA
388478,16:21723592:A>C,NM_144672.3:c.1320+2168A>C,\N,\N,12/27,Unknown significance,\N,intron_variant,2.514,0.0014,1KG_AMR_AF,OTOA
388479,16:21723597:G>GC,NM_144672.3:c.1320+2175dup,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388480,16:21723674:A>T,NM_144672.3:c.1320+2250A>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.837,0.001,1KG_EAS_AF,OTOA
388481,16:21723684:A>G,NM_144672.3:c.1320+2260A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,1.723,\N,\N,OTOA
388482,16:21723690:A>G,NM_144672.3:c.1320+2266A>G,\N,\N,12/27,Benign,\N,intron_variant,1.653,0.1964,1KG_EAS_AF,OTOA
388483,16:21723779:G>A,NM_144672.3:c.1320+2355G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,2.334,\N,\N,OTOA
388484,16:21723792:G>A,NM_144672.3:c.1320+2368G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,6.344,0.0014,1KG_AMR_AF,OTOA
388485,16:21723796:T>C,NM_144672.3:c.1320+2372T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,7.131,0.0029,1KG_AMR_AF,OTOA
388486,16:21723802:T>C,NM_144672.3:c.1320+2378T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,7.713,0.001,1KG_EAS_AF,OTOA
388487,16:21723813:T>C,NM_144672.3:c.1320+2389T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,8.636,0.001,1KG_EUR_AF,OTOA
388488,16:21723833:G>A,NM_144672.3:c.1320+2409G>A,\N,\N,12/27,Benign,\N,intron_variant,4.271,0.0112,1KG_SAS_AF,OTOA
388489,16:21723834:T>C,NM_144672.3:c.1320+2410T>C,\N,\N,12/27,Benign,\N,intron_variant,2.524,0.1131,1KG_EAS_AF,OTOA
388490,16:21723889:C>T,NM_144672.3:c.1321-2417C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,9.213,0.001,1KG_EAS_AF,OTOA
388491,16:21723890:G>A,NM_144672.3:c.1321-2416G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,9.581,0.0014,1KG_AMR_AF,OTOA
388492,16:21723890:G>C,NM_144672.3:c.1321-2416G>C,\N,\N,12/27,Unknown significance,\N,intron_variant,6.437,\N,\N,OTOA
388493,16:21723900:G>A,NM_144672.3:c.1321-2406G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,9.617,0.001,1KG_SAS_AF,OTOA
388494,16:21723909:C>T,NM_144672.3:c.1321-2397C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,9.588,0.002,1KG_EAS_AF,OTOA
388495,16:21723923:A>G,NM_144672.3:c.1321-2383A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,8.125,\N,\N,OTOA
388496,16:21723936:C>G,NM_144672.3:c.1321-2370C>G,\N,\N,12/27,Unknown significance,\N,intron_variant,4.471,0.0008,1KG_AFR_AF,OTOA
388497,16:21723977:C>T,NM_144672.3:c.1321-2329C>T,\N,\N,12/27,Benign,\N,intron_variant,1.585,0.0159,1KG_EUR_AF,OTOA
388498,16:21724003:T>TA,NM_144672.3:c.1321-2290dup,\N,\N,12/27,Benign,\N,intron_variant,0.589,0.6829,1KG_EUR_AF,OTOA
388499,16:21724004:A>T,NM_144672.3:c.1321-2302A>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.135,0.001,1KG_SAS_AF,OTOA
388500,16:21724035:G>A,NM_144672.3:c.1321-2271G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.5,0.001,1KG_EUR_AF,OTOA
388501,16:21724045:A>G,NM_144672.3:c.1321-2261A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,3.445,0.001,1KG_EUR_AF,OTOA
388502,16:21724089:C>T,NM_144672.3:c.1321-2217C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.483,0.0008,1KG_AFR_AF,OTOA
388503,16:21724100:T>C,NM_144672.3:c.1321-2206T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.043,\N,\N,OTOA
388504,16:21724114:C>T,NM_144672.3:c.1321-2192C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.543,0.0008,1KG_AFR_AF,OTOA
388505,16:21724121:G>T,NM_144672.3:c.1321-2185G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.222,0.001,1KG_SAS_AF,OTOA
388506,16:21724146:C>A,NM_144672.3:c.1321-2160C>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.327,0.001,1KG_EAS_AF,OTOA
388507,16:21724163:G>C,NM_144672.3:c.1321-2143G>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.184,0.0008,1KG_AFR_AF,OTOA
388508,16:21724165:T>C,NM_144672.3:c.1321-2141T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.864,0.001,1KG_SAS_AF,OTOA
388509,16:21724207:G>A,NM_144672.3:c.1321-2099G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.674,\N,\N,OTOA
388510,16:21724249:G>A,NM_144672.3:c.1321-2057G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,2.793,\N,\N,OTOA
388511,16:21724259:C>T,NM_144672.3:c.1321-2047C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.548,0.004,1KG_EUR_AF,OTOA
388512,16:21724301:T>C,NM_144672.3:c.1321-2005T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,1.977,0.001,1KG_EUR_AF,OTOA
388513,16:21724313:C>T,NM_144672.3:c.1321-1993C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.554,\N,\N,OTOA
388514,16:21724371:A>AC,NM_144672.3:c.1321-1929dup,\N,\N,12/27,Unknown significance,\N,intron_variant,7.15,\N,\N,OTOA
388515,16:21724375:C>T,NM_144672.3:c.1321-1931C>T,\N,\N,12/27,Benign,\N,intron_variant,10.86,0.0778,1KG_AMR_AF,OTOA
388516,16:21724433:T>A,NM_144672.3:c.1321-1873T>A,\N,\N,12/27,Unknown significance,\N,intron_variant,4.161,0.002,1KG_SAS_AF,OTOA
388517,16:21724436:C>T,NM_144672.3:c.1321-1870C>T,\N,\N,12/27,Benign,\N,intron_variant,2.661,0.0068,1KG_AFR_AF,OTOA
388518,16:21724442:G>A,NM_144672.3:c.1321-1864G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,2.328,0.0008,1KG_AFR_AF,OTOA
388519,16:21724445:G>A,NM_144672.3:c.1321-1861G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.876,0.001,1KG_SAS_AF,OTOA
388520,16:21724509:C>T,NM_144672.3:c.1321-1797C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.916,\N,\N,OTOA
388521,16:21724517:C>T,NM_144672.3:c.1321-1789C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.541,\N,\N,OTOA
388522,16:21724535:C>G,NM_144672.3:c.1321-1771C>G,\N,\N,12/27,Unknown significance,\N,intron_variant,0.397,0.0015,1KG_AFR_AF,OTOA
388523,16:21724609:A>G,NM_144672.3:c.1321-1697A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,1.36,\N,\N,OTOA
388524,16:21724654:A>G,NM_144672.3:c.1321-1652A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,5.05,0.0014,1KG_AMR_AF,OTOA
388525,16:21724713:G>A,NM_144672.3:c.1321-1593G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,2.382,0.001,1KG_SAS_AF,OTOA
388526,16:21724743:G>A,NM_144672.3:c.1321-1563G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.818,0.001,1KG_SAS_AF,OTOA
388527,16:21724762:C>A,NM_144672.3:c.1321-1544C>A,\N,\N,12/27,Unknown significance,\N,intron_variant,5.049,0.0008,1KG_AFR_AF,OTOA
388528,16:21724773:G>A,NM_144672.3:c.1321-1533G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.817,0.001,1KG_EAS_AF,OTOA
388529,16:21724867:C>T,NM_144672.3:c.1321-1439C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,4.201,\N,\N,OTOA
388530,16:21724919:T>A,NM_144672.3:c.1321-1387T>A,\N,\N,12/27,Benign,\N,intron_variant,3.348,0.9887,1KG_AFR_AF,OTOA
388531,16:21724925:G>A,NM_144672.3:c.1321-1381G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,4.653,0.001,1KG_SAS_AF,OTOA
388532,16:21724927:T>C,NM_144672.3:c.1321-1379T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,3.941,\N,\N,OTOA
388533,16:21724934:T>C,NM_144672.3:c.1321-1372T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,1.091,\N,\N,OTOA
388534,16:21724942:G>A,NM_144672.3:c.1321-1364G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,2.318,0.0008,1KG_AFR_AF,OTOA
388535,16:21724947:T>A,NM_144672.3:c.1321-1359T>A,\N,\N,12/27,Unknown significance,\N,intron_variant,6.642,\N,\N,OTOA
388536,16:21724970:C>T,NM_144672.3:c.1321-1336C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.999,0.0014,1KG_AMR_AF,OTOA
388537,16:21725006:A>G,NM_144672.3:c.1321-1300A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,3.696,0.001,1KG_SAS_AF,OTOA
388538,16:21725047:G>A,NM_144672.3:c.1321-1259G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.559,0.003,1KG_EUR_AF,OTOA
388539,16:21725065:A>G,NM_144672.3:c.1321-1241A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,4.7,\N,\N,OTOA
388540,16:21725066:C>T,NM_144672.3:c.1321-1240C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.954,0.001,1KG_EUR_AF,OTOA
388541,16:21725067:G>A,NM_144672.3:c.1321-1239G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.183,\N,\N,OTOA
388542,16:21725127:C>T,NM_144672.3:c.1321-1179C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,7.616,\N,\N,OTOA
388543,16:21725134:A>G,NM_144672.3:c.1321-1172A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,8.918,0.0045,1KG_AFR_AF,OTOA
388544,16:21725176:C>A,NM_144672.3:c.1321-1130C>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.171,\N,\N,OTOA
388545,16:21725178:G>C,NM_144672.3:c.1321-1128G>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.639,\N,\N,OTOA
388546,16:21725182:C>A,NM_144672.3:c.1321-1124C>A,\N,\N,12/27,Unknown significance,\N,intron_variant,4.185,0.001,1KG_EAS_AF,OTOA
388547,16:21725198:T>C,NM_144672.3:c.1321-1108T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,8.696,0.001,1KG_EUR_AF,OTOA
388548,16:21725234:G>A,NM_144672.3:c.1321-1072G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,14.74,0.001,1KG_EAS_AF,OTOA
388549,16:21725240:C>T,NM_144672.3:c.1321-1066C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,7.729,0.0038,1KG_AFR_AF,OTOA
388550,16:21725288:A>G,NM_144672.3:c.1321-1018A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,2.038,0.001,1KG_SAS_AF,OTOA
388551,16:21725317:G>A,NM_144672.3:c.1321-989G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,11.58,\N,\N,OTOA
388552,16:21725330:C>T,NM_144672.3:c.1321-976C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,3.02,0.0045,1KG_AFR_AF,OTOA
388553,16:21725343:G>A,NM_144672.3:c.1321-963G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.107,0.0045,1KG_AFR_AF,OTOA
388554,16:21725343:G>T,NM_144672.3:c.1321-963G>T,\N,\N,12/27,Benign,\N,intron_variant,0.174,0.0079,1KG_EAS_AF,OTOA
388555,16:21725350:G>A,NM_144672.3:c.1321-956G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,4.823,\N,\N,OTOA
388556,16:21725393:A>G,NM_144672.3:c.1321-913A>G,\N,\N,12/27,Benign,\N,intron_variant,5.014,0.0427,1KG_EAS_AF,OTOA
388557,16:21725431:T>C,NM_144672.3:c.1321-875T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,1.335,0.003,1KG_AFR_AF,OTOA
388558,16:21725451:G>C,NM_144672.3:c.1321-855G>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.122,0.0014,1KG_AMR_AF,OTOA
388559,16:21725487:A>C,NM_144672.3:c.1321-819A>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.72,\N,\N,OTOA
388560,16:21725493:G>GA,NM_144672.3:c.1321-805dup,\N,\N,12/27,Unknown significance,\N,intron_variant,0.75,\N,\N,OTOA
388561,16:21725494:A>G,NM_144672.3:c.1321-812A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,0.613,0.001,1KG_SAS_AF,OTOA
388562,16:21725512:ATTTC>A,NM_144672.3:c.1321-780_1321-777del,\N,\N,12/27,Unknown significance,\N,intron_variant,3.669,\N,\N,OTOA
388563,16:21725564:T>C,NM_144672.3:c.1321-742T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,2.209,\N,\N,OTOA
388564,16:21725566:T>C,NM_144672.3:c.1321-740T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,1.47,\N,\N,OTOA
388565,16:21725572:TTTTC>T,NM_144672.3:c.1321-713_1321-710del,\N,\N,12/27,Unknown significance,\N,intron_variant,3.101,\N,\N,OTOA
388566,16:21725572:TTTTCTTTC>T,NM_144672.3:c.1321-717_1321-710del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388567,16:21725573:T>C,NM_144672.3:c.1321-733T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.925,\N,\N,OTOA
388568,16:21725576:C>T,NM_144672.3:c.1321-730C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.983,\N,\N,OTOA
388569,16:21725578:TTCTTTC>T,NM_144672.3:c.1321-726_1321-721del,\N,\N,12/27,Unknown significance,\N,intron_variant,2.928,\N,\N,OTOA
388570,16:21725582:TTCTT>C,NM_144672.3:c.1321-724_1321-720delinsC,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388571,16:21725593:T>C,NM_144672.3:c.1321-713T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,1.655,\N,\N,OTOA
388572,16:21725595:T>C,NM_144672.3:c.1321-711T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,3.512,\N,\N,OTOA
388573,16:21725595:TCCTCCTTC>T,NM_144672.3:c.1321-709_1321-702del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388574,16:21725597:C>T,NM_144672.3:c.1321-709C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,4.17,\N,\N,OTOA
388575,16:21725603:C>T,NM_144672.3:c.1321-703C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.62,\N,\N,OTOA
388576,16:21725612:C>T,NM_144672.3:c.1321-694C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.914,\N,\N,OTOA
388577,16:21725613:T>C,NM_144672.3:c.1321-693T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,2.625,\N,\N,OTOA
388578,16:21725614:T>C,NM_144672.3:c.1321-692T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,3.487,\N,\N,OTOA
388579,16:21725617:C>CCTTT,NM_144672.3:c.1321-685_1321-682dup,\N,\N,12/27,Unknown significance,\N,intron_variant,6.06,\N,\N,OTOA
388580,16:21725617:C>T,NM_144672.3:c.1321-689C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,5.239,\N,\N,OTOA
388581,16:21725617:CCTTT>C,NM_144672.3:c.1321-685_1321-682del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388582,16:21725621:T>C,NM_144672.3:c.1321-685T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,1.296,\N,\N,OTOA
388583,16:21725621:T>TCTTC,NM_144672.3:c.1321-653_1321-650dup,\N,\N,12/27,Unknown significance,\N,intron_variant,2.523,\N,\N,OTOA
388584,16:21725621:T>TCTTCCTTC,NM_144672.3:c.1321-657_1321-650dup,\N,\N,12/27,Unknown significance,\N,intron_variant,1.956,\N,\N,OTOA
388585,16:21725621:TCTTC>T,NM_144672.3:c.1321-653_1321-650del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388586,16:21725623:T>TTCCTTCCC,NM_144672.3:c.1321-676_1321-675insCTCCTTCC,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388587,16:21725625:C>T,NM_144672.3:c.1321-681C>T,\N,\N,12/27,Benign,\N,intron_variant,2.435,0.1796,1KG_EAS_AF,OTOA
388588,16:21725633:C>T,NM_144672.3:c.1321-673C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,6.455,0.001,1KG_EUR_AF,OTOA
388589,16:21725641:C>T,NM_144672.3:c.1321-665C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,5.332,\N,\N,OTOA
388590,16:21725653:C>CCTTT,NM_144672.3:c.1321-635_1321-632dup,\N,\N,12/27,Unknown significance,\N,intron_variant,5.533,\N,\N,OTOA
388591,16:21725653:C>T,NM_144672.3:c.1321-653C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.616,\N,\N,OTOA
388592,16:21725654:C>CTTCA,NM_144672.3:c.1321-650_1321-649insCATT,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388593,16:21725654:C>CTTCCTTCG,NM_144672.3:c.1321-650_1321-649insCCTTCGTT,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388594,16:21725657:T>C,NM_144672.3:c.1321-649T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.458,\N,\N,OTOA
388595,16:21725658:CTTT>C,NM_144672.3:c.1321-647_1321-645del,\N,\N,12/27,Unknown significance,\N,intron_variant,5.941,\N,\N,OTOA
388596,16:21725661:T>C,NM_144672.3:c.1321-645T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.383,\N,\N,OTOA
388597,16:21725679:T>C,NM_144672.3:c.1321-627T>C,\N,\N,12/27,Benign,\N,intron_variant,2.339,0.0098,1KG_AFR_AF,OTOA
388598,16:21725680:CTCTT>C,NM_144672.3:c.1321-618_1321-615del,\N,\N,12/27,Unknown significance,\N,intron_variant,4.544,\N,\N,OTOA
388599,16:21725684:T>C,NM_144672.3:c.1321-622T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.138,\N,\N,OTOA
388600,16:21725686:CTT>C,NM_144672.3:c.1321-618_1321-617del,\N,\N,12/27,Unknown significance,\N,intron_variant,5.072,\N,\N,OTOA
388601,16:21725687:T>C,NM_144672.3:c.1321-619T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.707,\N,\N,OTOA
388602,16:21725690:CTCTCTCTT>C,NM_144672.3:c.1321-596_1321-589del,\N,\N,12/27,Unknown significance,\N,intron_variant,2.64,\N,\N,OTOA
388603,16:21725692:C>T,NM_144672.3:c.1321-614C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.208,\N,\N,OTOA
388604,16:21725698:T>C,NM_144672.3:c.1321-608T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.928,\N,\N,OTOA
388605,16:21725702:C>T,NM_144672.3:c.1321-604C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.97,\N,\N,OTOA
388606,16:21725702:CTCTT>C,NM_144672.3:c.1321-600_1321-597del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388607,16:21725704:CTTTCTCT>C,NM_144672.3:c.1321-601_1321-595del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388608,16:21725704:CTTTCTCTCTTTCTT>C,NM_144672.3:c.1321-600_1321-587del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388609,16:21725706:T>C,NM_144672.3:c.1321-600T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.032,\N,\N,OTOA
388610,16:21725708:C>CTT,NM_144672.3:c.1321-597_1321-596insTT,\N,\N,12/27,Unknown significance,\N,intron_variant,0.76,\N,\N,OTOA
388611,16:21725708:CTCTCTTTCTT>C,NM_144672.3:c.1321-574_1321-565del,\N,\N,12/27,Unknown significance,\N,intron_variant,0.796,\N,\N,OTOA
388612,16:21725710:C>CTCTT,NM_144672.3:c.1321-588_1321-585dup,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388613,16:21725710:C>T,NM_144672.3:c.1321-596C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.333,\N,\N,OTOA
388614,16:21725716:CTT>C,NM_144672.3:c.1321-588_1321-587del,\N,\N,12/27,Unknown significance,\N,intron_variant,2.998,\N,\N,OTOA
388615,16:21725731:T>TTTC,NM_144672.3:c.1321-575_1321-574insTTC,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388616,16:21725731:TC>T,NM_144672.3:c.1321-574del,\N,\N,12/27,Unknown significance,\N,intron_variant,0.027,\N,\N,OTOA
388617,16:21725767:T>C,NM_144672.3:c.1321-539T>C,\N,\N,12/27,Benign,\N,intron_variant,0.66,0.0542,1KG_SAS_AF,OTOA
388618,16:21725780:T>TCTTC,NM_144672.3:c.1321-525_1321-522dup,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388619,16:21725780:TC>T,NM_144672.3:c.1321-525del,\N,\N,12/27,Unknown significance,\N,intron_variant,0.18,\N,\N,OTOA
388620,16:21725781:C>CCT,NM_144672.3:c.1321-525_1321-524insCT,\N,\N,12/27,Unknown significance,\N,intron_variant,0.756,\N,\N,OTOA
388621,16:21725781:C>CTTCT,NM_144672.3:c.1321-509_1321-506dup,\N,\N,12/27,Unknown significance,\N,intron_variant,0.639,\N,\N,OTOA
388622,16:21725781:C>CTTCTTTCT,NM_144672.3:c.1321-513_1321-506dup,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388623,16:21725788:C>CTT,NM_144672.3:c.1321-516_1321-515dup,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388624,16:21725789:T>TTTTC,NM_144672.3:c.1321-515_1321-514insTCTT,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388625,16:21725797:T>TTTTC,NM_144672.3:c.1321-507_1321-506insTCTT,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388626,16:21725798:T>TTC,NM_144672.3:c.1321-507_1321-506dup,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388627,16:21725799:T>TCTTC,NM_144672.3:c.1321-506_1321-505insTTCC,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388628,16:21725799:TC>T,NM_144672.3:c.1321-505del,\N,\N,12/27,Unknown significance,\N,intron_variant,0.674,\N,\N,OTOA
388629,16:21725800:C>CTTT,NM_144672.3:c.1321-506_1321-505insTTT,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388630,16:21725800:C>CTTTT,NM_144672.3:c.1321-506_1321-505insTTTT,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388631,16:21725801:C>T,NM_144672.3:c.1321-505C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.115,\N,\N,OTOA
388632,16:21725802:T>TTCCA,NM_144672.3:c.1321-504_1321-503insTCCA,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388633,16:21725802:TCTCC>T,NM_144672.3:c.1321-500_1321-497del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388634,16:21725803:C>T,NM_144672.3:c.1321-503C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.943,\N,\N,OTOA
388635,16:21725804:T>C,NM_144672.3:c.1321-502T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.225,\N,\N,OTOA
388636,16:21725804:TC>T,NM_144672.3:c.1321-499del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388637,16:21725806:C>T,NM_144672.3:c.1321-500C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.801,\N,\N,OTOA
388638,16:21725806:CCT>C,NM_144672.3:c.1321-485_1321-484del,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388639,16:21725806:CCTCT>C,NM_144672.3:c.1321-487_1321-484del,\N,\N,12/27,Unknown significance,\N,intron_variant,1.578,\N,\N,OTOA
388640,16:21725810:T>C,NM_144672.3:c.1321-496T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.9,\N,\N,OTOA
388641,16:21725812:T>C,NM_144672.3:c.1321-494T>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.896,\N,\N,OTOA
388642,16:21725815:C>CTTTT,NM_144672.3:c.1321-490_1321-489insTTTT,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388643,16:21725815:CTCTCTCTT>C,NM_144672.3:c.1321-487_1321-480del,\N,\N,12/27,Unknown significance,\N,intron_variant,2.901,\N,\N,OTOA
388644,16:21725815:CTCTCTCTTTCTT>C,NM_144672.3:c.1321-487_1321-476del,\N,\N,12/27,Unknown significance,\N,intron_variant,1.257,\N,\N,OTOA
388645,16:21725817:C>CTT,NM_144672.3:c.1321-488_1321-487insTT,\N,\N,12/27,Unknown significance,\N,intron_variant,1.277,\N,\N,OTOA
388646,16:21725819:C>CTCTTTCTT,NM_144672.3:c.1321-469_1321-462dup,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388647,16:21725819:C>T,NM_144672.3:c.1321-487C>T,\N,\N,12/27,Benign,\N,intron_variant,0.297,0.5547,1KG_EUR_AF,OTOA
388648,16:21725819:CTCTT>C,NM_144672.3:c.1321-465_1321-462del,\N,\N,12/27,Unknown significance,\N,intron_variant,3.243,\N,\N,OTOA
388649,16:21725821:CTT>C,NM_144672.3:c.1321-483_1321-482del,\N,\N,12/27,Unknown significance,\N,intron_variant,1.022,\N,\N,OTOA
388650,16:21725823:T>C,NM_144672.3:c.1321-483T>C,\N,\N,12/27,Benign,\N,intron_variant,0.117,0.2107,1KG_EUR_AF,OTOA
388651,16:21725829:C>CT,NM_144672.3:c.1321-474dup,\N,\N,12/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388652,16:21725854:C>T,NM_144672.3:c.1321-452C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.419,\N,\N,OTOA
388653,16:21725882:G>A,NM_144672.3:c.1321-424G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.155,\N,\N,OTOA
388654,16:21725932:A>G,NM_144672.3:c.1321-374A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,0.344,\N,\N,OTOA
388655,16:21725999:A>G,NM_144672.3:c.1321-307A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,2.81,0.001,1KG_SAS_AF,OTOA
388656,16:21726028:G>A,NM_144672.3:c.1321-278G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.127,0.0014,1KG_AMR_AF,OTOA
388657,16:21726106:C>T,NM_144672.3:c.1321-200C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,2.683,0.0038,1KG_AFR_AF,OTOA
388658,16:21726108:G>A,NM_144672.3:c.1321-198G>A,\N,\N,12/27,Benign,\N,intron_variant,2.557,0.0072,1KG_SAS_AF,OTOA
388659,16:21726113:G>T,NM_144672.3:c.1321-193G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.302,0.003,1KG_EUR_AF,OTOA
388660,16:21726115:G>A,NM_144672.3:c.1321-191G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,0.149,0.0008,1KG_AFR_AF,OTOA
388661,16:21726119:C>T,NM_144672.3:c.1321-187C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.01,0.0014,1KG_AMR_AF,OTOA
388662,16:21726214:A>G,NM_144672.3:c.1321-92A>G,\N,\N,12/27,Unknown significance,\N,intron_variant,4.016,\N,\N,OTOA
388663,16:21726216:C>A,NM_144672.3:c.1321-90C>A,\N,\N,12/27,Unknown significance,\N,intron_variant,4.111,0.001,1KG_SAS_AF,OTOA
388664,16:21726256:G>A,NM_144672.3:c.1321-50G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,8.093,\N,\N,OTOA
388665,16:21726256:G>T,NM_144672.3:c.1321-50G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,6.389,0.0000150539,EXAC_NFE_AF,OTOA
388666,16:21726258:G>A,NM_144672.3:c.1321-48G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,10.91,0.000454752,EVS_AA_AF,OTOA
388667,16:21726266:G>A,NM_144672.3:c.1321-40G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,4.835,\N,\N,OTOA
388668,16:21726267:C>T,NM_144672.3:c.1321-39C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,4.296,0.001,1KG_SAS_AF,OTOA
388669,16:21726268:G>T,NM_144672.3:c.1321-38G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.082,0.0000150525,EXAC_NFE_AF,OTOA
388670,16:21726270:G>A,NM_144672.3:c.1321-36G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,5.666,0.000116225,EXAC_EAS_AF,OTOA
388671,16:21726273:C>T,NM_144672.3:c.1321-33C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,5.578,0.0000864155,EXAC_AMR_AF,OTOA
388672,16:21726277:G>A,NM_144672.3:c.1321-29G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,3.05,\N,\N,OTOA
388673,16:21726283:C>T,NM_144672.3:c.1321-23C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,5.12,0.000060562,EXAC_SAS_AF,OTOA
388674,16:21726284:T>G,NM_144672.3:c.1321-22T>G,\N,\N,12/27,Unknown significance,\N,intron_variant,2.943,\N,\N,OTOA
388675,16:21726285:G>A,NM_144672.3:c.1321-21G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,2.192,0.0000150376,EXAC_NFE_AF,OTOA
388676,16:21726286:C>G,NM_144672.3:c.1321-20C>G,\N,\N,12/27,Unknown significance,\N,intron_variant,0.105,0.000096432,EXAC_AFR_AF,OTOA
388677,16:21726286:C>T,NM_144672.3:c.1321-20C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,0.289,0.00011609,EXAC_EAS_AF,OTOA
388678,16:21726287:G>A,NM_144672.3:c.1321-19G>A,\N,\N,12/27,Unknown significance,\N,intron_variant,1.351,0.000015038,EXAC_NFE_AF,OTOA
388679,16:21726290:G>T,NM_144672.3:c.1321-16G>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.156,\N,\N,OTOA
388680,16:21726292:C>T,NM_144672.3:c.1321-14C>T,\N,\N,12/27,Unknown significance,\N,intron_variant,1.174,0.000181686,EXAC_SAS_AF,OTOA
388681,16:21726293:G>A,NM_144672.3:c.1321-13G>A,\N,\N,12/27,Benign,\N,intron_variant,2.183,0.005,OTO_TR_AF,OTOA
388682,16:21726293:G>C,NM_144672.3:c.1321-13G>C,\N,\N,12/27,Unknown significance,\N,intron_variant,0.46,0.0000300562,EXAC_NFE_AF,OTOA
388683,16:21726296:C>G,NM_144672.3:c.1321-10C>G,\N,\N,12/27,Unknown significance,\N,intron_variant,1.75,0.0000450789,EXAC_NFE_AF,OTOA
388684,16:21726306:G>A,NM_144672.3:c.1321G>A,NP_653273.3:p.Val441Met,13/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,22.9,0.000115982,EXAC_EAS_AF,OTOA
388685,16:21726322:A>G,NM_144672.3:c.1337A>G,NP_653273.3:p.Asn446Ser,13/28,\N,Likely benign,\N,missense_variant,0.016,0.003125,OTO_US_AF,OTOA
388686,16:21726326:C>A,NM_144672.3:c.1341C>A,NP_653273.3:p.Val447=,13/28,\N,Unknown significance,\N,synonymous_variant,8.987,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
388687,16:21726332:G>A,NM_144672.3:c.1347G>A,NP_653273.3:p.Gln449=,13/28,\N,Unknown significance,\N,synonymous_variant,2.792,0.000015002,EXAC_NFE_AF,OTOA
388688,16:21726337:G>A,NM_144672.3:c.1352G>A,NP_653273.3:p.Gly451Asp,13/28,\N,Pathogenic,Hearing loss| non-syndromic,missense_variant,24.8,0.000060562,EXAC_SAS_AF,OTOA
388689,16:21726338:C>T,NM_144672.3:c.1353C>T,NP_653273.3:p.Gly451=,13/28,\N,Benign,\N,synonymous_variant,11.34,0.005,OTO_TR_AF,OTOA
388690,16:21726339:G>A,NM_144672.3:c.1354G>A,NP_653273.3:p.Ala452Thr,13/28,\N,Likely benign,\N,missense_variant,7.562,0.000060562,EXAC_SAS_AF,OTOA
388691,16:21726339:G>T,NM_144672.3:c.1354G>T,NP_653273.3:p.Ala452Ser,13/28,\N,Likely benign,\N,missense_variant,0.503,0.0000149997,EXAC_NFE_AF,OTOA
388692,16:21726342:C>T,NM_144672.3:c.1357C>T,NP_653273.3:p.Leu453=,13/28,\N,Unknown significance,\N,synonymous_variant,7.905,0.000181686,EXAC_SAS_AF,OTOA
388693,16:21726353:G>GCC,NM_144672.3:c.1368_1369insCC,NP_653273.3:p.Val457ProfsTer10,13/28,\N,Unknown significance,\N,frameshift_variant,31,\N,\N,OTOA
388694,16:21726354:G>T,NM_144672.3:c.1369G>T,NP_653273.3:p.Val457Phe,13/28,\N,Unknown significance,\N,missense_variant,25.8,0.000044987,EXAC_NFE_AF,OTOA
388695,16:21726356:C>A,NM_144672.3:c.1371C>A,NP_653273.3:p.Val457=,13/28,\N,Unknown significance,\N,synonymous_variant,14.39,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
388696,16:21726357:A>T,NM_144672.3:c.1372A>T,NP_653273.3:p.Ser458Cys,13/28,\N,Likely benign,\N,missense_variant,21,0.0000449802,EXAC_NFE_AF,OTOA
388697,16:21726368:C>T,NM_144672.3:c.1383C>T,NP_653273.3:p.Ala461=,13/28,\N,Unknown significance,\N,synonymous_variant,15.41,0.00011566,EXAC_EAS_AF,OTOA
388698,16:21726371:C>T,NM_144672.3:c.1386C>T,NP_653273.3:p.Phe462=,13/28,\N,Unknown significance,\N,synonymous_variant,14.6,\N,\N,OTOA
388699,16:21726379:T>G,NM_144672.3:c.1394T>G,NP_653273.3:p.Met465Arg,13/28,\N,Unknown significance,\N,missense_variant,26.7,0.0000863707,EXAC_AMR_AF,OTOA
388700,16:21726382:A>C,NM_144672.3:c.1397A>C,NP_653273.3:p.Lys466Thr,13/28,\N,Likely benign,\N,missense_variant,14.78,0.000227376,EVS_AA_AF,OTOA
388701,16:21726383:A>G,NM_144672.3:c.1398A>G,NP_653273.3:p.Lys466=,13/28,\N,Unknown significance,\N,synonymous_variant,0.845,0.00011566,EXAC_EAS_AF,OTOA
388702,16:21726384:C>T,NM_144672.3:c.1399C>T,NP_653273.3:p.Arg467Cys,13/28,\N,Likely benign,\N,missense_variant,12.46,0.0000149885,EXAC_NFE_AF,OTOA
388703,16:21726385:G>A,NM_144672.3:c.1400G>A,NP_653273.3:p.Arg467His,13/28,\N,Likely benign,\N,missense_variant,11.27,0.00277778,OTO_ES_AF,OTOA
388704,16:21726389:G>T,NM_144672.3:c.1404G>T,NP_653273.3:p.Lys468Asn,13/28,\N,Unknown significance,\N,missense_variant,21.2,0.001,1KG_EUR_AF,OTOA
388705,16:21726392:C>T,NM_144672.3:c.1407C>T,NP_653273.3:p.Asp469=,13/28,\N,Unknown significance,\N,synonymous_variant,10.3,0.0000299751,EXAC_NFE_AF,OTOA
388706,16:21726398:G>A,NM_144672.3:c.1413G>A,NP_653273.3:p.Ser471=,13/28,\N,Unknown significance,\N,synonymous_variant,10.23,0.000239808,EXAC_NFE_AF,OTOA
388707,16:21726409:G>A,NM_144672.3:c.1424G>A,NP_653273.3:p.Arg475Lys,13/28,\N,Unknown significance,\N,missense_variant,12.99,0.00010491,EXAC_NFE_AF,OTOA
388708,16:21726413:T>C,NM_144672.3:c.1428T>C,NP_653273.3:p.Ser476=,13/28,\N,Unknown significance,\N,synonymous_variant,0.15,0.000060562,EXAC_SAS_AF,OTOA
388709,16:21726414:G>C,NM_144672.3:c.1429G>C,NP_653273.3:p.Ala477Pro,13/28,\N,Likely benign,\N,missense_variant,0.109,0.000348837,EVS_EA_AF,OTOA
388710,16:21726416:C>T,NM_144672.3:c.1431C>T,NP_653273.3:p.Ala477=,13/28,\N,Unknown significance,\N,synonymous_variant,12.45,0.000060562,EXAC_SAS_AF,OTOA
388711,16:21726417:G>A,NM_144672.3:c.1432G>A,NP_653273.3:p.Val478Ile,13/28,\N,Likely benign,\N,missense_variant,0.001,0.001,1KG_SAS_AF,OTOA
388712,16:21726422:C>A,NM_144672.3:c.1437C>A,NP_653273.3:p.Ser479=,13/28,\N,Unknown significance,\N,synonymous_variant,10.23,0.000116279,EVS_EA_AF,OTOA
388713,16:21726423:C>T,NM_144672.3:c.1438C>T,NP_653273.3:p.Gln480Ter,13/28,\N,Unknown significance,\N,stop_gained,35,0.0000149858,EXAC_NFE_AF,OTOA
388714,16:21726425:G>T,NM_144672.3:c.1440G>T,NP_653273.3:p.Gln480His,13/28,\N,Unknown significance,\N,missense_variant,8.112,0.0014,1KG_AMR_AF,OTOA
388715,16:21726426:T>C,NM_144672.3:c.1441T>C,NP_653273.3:p.Tyr481His,13/28,\N,Likely benign,\N,missense_variant,0.005,0.0000863707,EXAC_AMR_AF,OTOA
388716,16:21726427:A>T,NM_144672.3:c.1442A>T,NP_653273.3:p.Tyr481Phe,13/28,\N,Unknown significance,\N,missense_variant,6.215,0.000151194,EXAC_FIN_AF,OTOA
388717,16:21726428:T>A,NM_144672.3:c.1443T>A,NP_653273.3:p.Tyr481Ter,13/28,\N,Unknown significance,\N,stop_gained,22.7,0.000151194,EXAC_FIN_AF,OTOA
388718,16:21726430:T>C,NM_144672.3:c.1445T>C,NP_653273.3:p.Val482Ala,13/28,\N,Likely benign,\N,missense_variant,0.011,0.0000863707,EXAC_AMR_AF,OTOA
388719,16:21726433:C>A,NM_144672.3:c.1448C>A,NP_653273.3:p.Ser483Tyr,13/28,\N,Unknown significance,\N,missense_variant,15.31,0.000227376,EVS_AA_AF,OTOA
388720,16:21726434:C>T,NM_144672.3:c.1449C>T,NP_653273.3:p.Ser483=,13/28,\N,Unknown significance,\N,synonymous_variant,7.045,0.0000449573,EXAC_NFE_AF,OTOA
388721,16:21726435:G>A,NM_170664.2:c.478G>A,NP_733764.1:p.Asp160Asn,4/19,\N,Likely benign,\N,missense_variant,8.054,0.000116279,EVS_EA_AF,OTOA
388722,16:21726440:G>C,NM_144672.3:c.1455G>C,NP_653273.3:p.Leu485Phe,13/28,\N,Unknown significance,\N,missense_variant,24.3,\N,\N,OTOA
388723,16:21726460:G>A,NM_144672.3:c.1475G>A,NP_653273.3:p.Gly492Asp,13/28,\N,Unknown significance,\N,missense_variant,25.9,0.0000149871,EXAC_NFE_AF,OTOA
388724,16:21726468:A>G,NM_144672.3:c.1483A>G,NP_653273.3:p.Ser495Gly,13/28,\N,Likely benign,\N,missense_variant,18.03,0.000227376,EVS_AA_AF,OTOA
388725,16:21726469:G>A,NM_144672.3:c.1484G>A,NP_653273.3:p.Ser495Asn,13/28,\N,Unknown significance,\N,missense_variant,24.5,0.00011558,EXAC_EAS_AF,OTOA
388726,16:21726475:T>A,NM_144672.3:c.1488+2T>A,\N,\N,13/27,Unknown significance,\N,splice_donor_variant,26,0.0000299751,EXAC_NFE_AF,OTOA
388727,16:21726481:G>A,NM_144672.3:c.1488+8G>A,\N,\N,13/27,Unknown significance,\N,splice_region_variant&intron_variant,10.71,0.000227376,EVS_AA_AF,OTOA
388728,16:21726485:A>G,NM_144672.3:c.1488+12A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,7.37,0.000060562,EXAC_SAS_AF,OTOA
388729,16:21726489:C>G,NM_144672.3:c.1488+16C>G,\N,\N,13/27,Unknown significance,\N,intron_variant,4.405,0.000116279,EVS_EA_AF,OTOA
388730,16:21726494:G>A,NM_144672.3:c.1488+21G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,5.382,0.002,1KG_EUR_AF,OTOA
388731,16:21726494:G>C,NM_144672.3:c.1488+21G>C,\N,\N,13/27,Unknown significance,\N,intron_variant,1.84,0.0000149889,EXAC_NFE_AF,OTOA
388732,16:21726495:C>T,NM_144672.3:c.1488+22C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,7.683,0.0000149889,EXAC_NFE_AF,OTOA
388733,16:21726503:C>A,NM_144672.3:c.1488+30C>A,\N,\N,13/27,Unknown significance,\N,intron_variant,5.321,0.0000299832,EXAC_NFE_AF,OTOA
388734,16:21726507:T>A,NM_144672.3:c.1488+34T>A,\N,\N,13/27,Unknown significance,\N,intron_variant,7.366,0.0043,1KG_AMR_AF,OTOA
388735,16:21726516:G>T,NM_144672.3:c.1488+43G>T,\N,\N,13/27,Unknown significance,\N,intron_variant,0.739,0.000227376,EVS_AA_AF,OTOA
388736,16:21726519:T>C,NM_144672.3:c.1488+46T>C,\N,\N,13/27,Unknown significance,\N,intron_variant,3.246,0.000115741,EXAC_EAS_AF,OTOA
388737,16:21726526:G>A,NM_144672.3:c.1488+53G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,4.881,\N,\N,OTOA
388738,16:21726557:A>G,NM_144672.3:c.1488+84A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,4.051,\N,\N,OTOA
388739,16:21726563:C>G,NM_144672.3:c.1488+90C>G,\N,\N,13/27,Benign,\N,intron_variant,2.016,0.0166,1KG_AFR_AF,OTOA
388740,16:21726577:G>A,NM_144672.3:c.1488+104G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,3.277,0.0008,1KG_AFR_AF,OTOA
388741,16:21726579:C>T,NM_144672.3:c.1488+106C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,6.355,0.0014,1KG_AMR_AF,OTOA
388742,16:21726626:C>A,NM_144672.3:c.1488+153C>A,\N,\N,13/27,Unknown significance,\N,intron_variant,3.549,0.004,1KG_EAS_AF,OTOA
388743,16:21726650:C>T,NM_144672.3:c.1488+177C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,3.413,0.002,1KG_EAS_AF,OTOA
388744,16:21726659:A>G,NM_144672.3:c.1488+186A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,3.188,\N,\N,OTOA
388745,16:21726679:C>A,NM_144672.3:c.1488+206C>A,\N,\N,13/27,Unknown significance,\N,intron_variant,1.036,\N,\N,OTOA
388746,16:21726692:CCAGA>C,NM_144672.3:c.1488+223_1488+226del,\N,\N,13/27,Unknown significance,\N,intron_variant,4.743,0.002,1KG_EAS_AF,OTOA
388747,16:21726727:A>G,NM_144672.3:c.1488+254A>G,\N,\N,13/27,Benign,\N,intron_variant,2.072,0.0068,1KG_AFR_AF,OTOA
388748,16:21726729:G>T,NM_144672.3:c.1488+256G>T,\N,\N,13/27,Benign,\N,intron_variant,1.085,0.0734,1KG_AFR_AF,OTOA
388749,16:21726760:G>GT,NM_144672.3:c.1488+290dup,\N,\N,13/27,Unknown significance,\N,intron_variant,0.741,\N,\N,OTOA
388750,16:21726763:TG>T,NM_144672.3:c.1488+291del,\N,\N,13/27,Unknown significance,\N,intron_variant,0.942,\N,\N,OTOA
388751,16:21726764:G>T,NM_144672.3:c.1488+291G>T,\N,\N,13/27,Benign,\N,intron_variant,0.159,0.9887,1KG_AFR_AF,OTOA
388752,16:21726841:C>T,NM_144672.3:c.1488+368C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,0.875,\N,\N,OTOA
388753,16:21726959:G>A,NM_144672.3:c.1488+486G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,1.992,0.001,1KG_SAS_AF,OTOA
388754,16:21726994:A>G,NM_144672.3:c.1488+521A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,1.026,\N,\N,OTOA
388755,16:21727037:C>T,NM_144672.3:c.1488+564C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,5.231,\N,\N,OTOA
388756,16:21727059:C>T,NM_144672.3:c.1488+586C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,1.362,0.0008,1KG_AFR_AF,OTOA
388757,16:21727085:T>C,NM_144672.3:c.1488+612T>C,\N,\N,13/27,Unknown significance,\N,intron_variant,0.58,\N,\N,OTOA
388758,16:21727111:T>A,NM_144672.3:c.1488+638T>A,\N,\N,13/27,Unknown significance,\N,intron_variant,7.315,0.0041,1KG_SAS_AF,OTOA
388759,16:21727112:T>C,NM_144672.3:c.1488+639T>C,\N,\N,13/27,Unknown significance,\N,intron_variant,3.54,0.0008,1KG_AFR_AF,OTOA
388760,16:21727116:G>T,NM_144672.3:c.1488+643G>T,\N,\N,13/27,Unknown significance,\N,intron_variant,2.98,\N,\N,OTOA
388761,16:21727155:A>G,NM_144672.3:c.1488+682A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,1.102,0.003,1KG_AFR_AF,OTOA
388762,16:21727160:A>G,NM_144672.3:c.1488+687A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,2.166,0.0014,1KG_AMR_AF,OTOA
388763,16:21727176:TC>T,NM_144672.3:c.1488+705del,\N,\N,13/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388764,16:21727185:G>A,NM_144672.3:c.1488+712G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,0.871,0.001,1KG_EAS_AF,OTOA
388765,16:21727223:G>A,NM_144672.3:c.1488+750G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,0.544,0.0008,1KG_AFR_AF,OTOA
388766,16:21727272:C>G,NM_144672.3:c.1488+799C>G,\N,\N,13/27,Unknown significance,\N,intron_variant,2.207,\N,\N,OTOA
388767,16:21727291:C>T,NM_144672.3:c.1488+818C>T,\N,\N,13/27,Benign,\N,intron_variant,4.376,0.0098,1KG_AFR_AF,OTOA
388768,16:21727313:C>G,NM_144672.3:c.1488+840C>G,\N,\N,13/27,Unknown significance,\N,intron_variant,4.501,0.002,1KG_EAS_AF,OTOA
388769,16:21727373:G>A,NM_144672.3:c.1489-855G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,4.357,0.0015,1KG_AFR_AF,OTOA
388770,16:21727382:T>C,NM_144672.3:c.1489-846T>C,\N,\N,13/27,Unknown significance,\N,intron_variant,1.201,0.0008,1KG_AFR_AF,OTOA
388771,16:21727436:G>A,NM_144672.3:c.1489-792G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,4.106,\N,\N,OTOA
388772,16:21727466:C>A,NM_144672.3:c.1489-762C>A,\N,\N,13/27,Unknown significance,\N,intron_variant,5.535,0.003,1KG_AFR_AF,OTOA
388773,16:21727469:G>A,NM_144672.3:c.1489-759G>A,\N,\N,13/27,Benign,\N,intron_variant,1.379,0.0258,1KG_EUR_AF,OTOA
388774,16:21727473:C>T,NM_144672.3:c.1489-755C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,2.581,\N,\N,OTOA
388775,16:21727482:A>G,NM_144672.3:c.1489-746A>G,\N,\N,13/27,Benign,\N,intron_variant,5.669,0.0061,1KG_SAS_AF,OTOA
388776,16:21727482:A>T,NM_144672.3:c.1489-746A>T,\N,\N,13/27,Unknown significance,\N,intron_variant,5.289,0.001,1KG_EAS_AF,OTOA
388777,16:21727484:A>G,NM_144672.3:c.1489-744A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,2.685,0.002,1KG_EUR_AF,OTOA
388778,16:21727488:C>CTGGGATTACAGG,NM_144672.3:c.1489-737_1489-726dup,\N,\N,13/27,Benign,\N,intron_variant,4.688,0.0734,1KG_AFR_AF,OTOA
388779,16:21727529:T>C,NM_144672.3:c.1489-699T>C,\N,\N,13/27,Unknown significance,\N,intron_variant,0.939,\N,\N,OTOA
388780,16:21727570:C>G,NM_144672.3:c.1489-658C>G,\N,\N,13/27,Unknown significance,\N,intron_variant,0.608,0.0014,1KG_AMR_AF,OTOA
388781,16:21727571:G>A,NM_144672.3:c.1489-657G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,1.78,0.0008,1KG_AFR_AF,OTOA
388782,16:21727640:C>T,NM_144672.3:c.1489-588C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,5.078,0.001,1KG_EUR_AF,OTOA
388783,16:21727641:G>C,NM_144672.3:c.1489-587G>C,\N,\N,13/27,Benign,\N,intron_variant,1.174,0.9887,1KG_AFR_AF,OTOA
388784,16:21727687:T>C,NM_144672.3:c.1489-541T>C,\N,\N,13/27,Unknown significance,\N,intron_variant,3.621,0.001,1KG_SAS_AF,OTOA
388785,16:21727689:G>A,NM_144672.3:c.1489-539G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,3.671,0,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,OTOA
388786,16:21727710:G>A,NM_144672.3:c.1489-518G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,4.837,0.0008,1KG_AFR_AF,OTOA
388787,16:21727719:C>T,NM_144672.3:c.1489-509C>T,\N,\N,13/27,Benign,\N,intron_variant,7.353,0.0526,1KG_EAS_AF,OTOA
388788,16:21727720:G>A,NM_144672.3:c.1489-508G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,3.32,0.001,1KG_EUR_AF,OTOA
388789,16:21727733:A>C,NM_144672.3:c.1489-495A>C,\N,\N,13/27,Unknown significance,\N,intron_variant,2.441,\N,\N,OTOA
388790,16:21727749:G>A,NM_144672.3:c.1489-479G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,1.577,\N,\N,OTOA
388791,16:21727763:A>G,NM_144672.3:c.1489-465A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,5.387,\N,\N,OTOA
388792,16:21727784:C>T,NM_144672.3:c.1489-444C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,4.609,0.0043,1KG_AMR_AF,OTOA
388793,16:21727835:C>G,NM_144672.3:c.1489-393C>G,\N,\N,13/27,Unknown significance,\N,intron_variant,1.279,\N,\N,OTOA
388794,16:21727835:C>T,NM_144672.3:c.1489-393C>T,\N,\N,13/27,Benign,\N,intron_variant,2.187,0.0091,1KG_AFR_AF,OTOA
388795,16:21727852:A>T,NM_144672.3:c.1489-376A>T,\N,\N,13/27,Unknown significance,\N,intron_variant,0.427,0.0023,1KG_AFR_AF,OTOA
388796,16:21727854:T>G,NM_144672.3:c.1489-374T>G,\N,\N,13/27,Unknown significance,\N,intron_variant,6.233,\N,\N,OTOA
388797,16:21727860:C>G,NM_144672.3:c.1489-368C>G,\N,\N,13/27,Unknown significance,\N,intron_variant,3.284,0.0014,1KG_AMR_AF,OTOA
388798,16:21727915:C>T,NM_144672.3:c.1489-313C>T,\N,\N,13/27,Benign,\N,intron_variant,10.3,0.0149,1KG_EUR_AF,OTOA
388799,16:21727958:A>G,NM_144672.3:c.1489-270A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,1.309,\N,\N,OTOA
388800,16:21727962:G>A,NM_144672.3:c.1489-266G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,2.46,\N,\N,OTOA
388801,16:21727991:A>G,NM_144672.3:c.1489-237A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,2.489,\N,\N,OTOA
388802,16:21728002:T>G,NM_144672.3:c.1489-226T>G,\N,\N,13/27,Unknown significance,\N,intron_variant,4.806,\N,\N,OTOA
388803,16:21728004:G>C,NM_144672.3:c.1489-224G>C,\N,\N,13/27,Unknown significance,\N,intron_variant,2.898,\N,\N,OTOA
388804,16:21728013:A>C,NM_144672.3:c.1489-215A>C,\N,\N,13/27,Benign,\N,intron_variant,1.644,0.0068,1KG_AFR_AF,OTOA
388805,16:21728035:T>TA,NM_144672.3:c.1489-192dup,\N,\N,13/27,Unknown significance,\N,intron_variant,4.059,0.0043,1KG_AMR_AF,OTOA
388806,16:21728048:C>T,NM_144672.3:c.1489-180C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,4.787,\N,\N,OTOA
388807,16:21728089:G>C,NM_144672.3:c.1489-139G>C,\N,\N,13/27,Benign,\N,intron_variant,1.703,0.0734,1KG_AFR_AF,OTOA
388808,16:21728100:A>C,NM_144672.3:c.1489-128A>C,\N,\N,13/27,Unknown significance,\N,intron_variant,1.169,\N,\N,OTOA
388809,16:21728126:C>T,NM_144672.3:c.1489-102C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,1.357,\N,\N,OTOA
388810,16:21728126:CG>C,NM_144672.3:c.1489-99del,\N,\N,13/27,Benign,\N,intron_variant,0.222,0.0734,1KG_AFR_AF,OTOA
388811,16:21728129:G>T,NM_144672.3:c.1489-99G>T,\N,\N,13/27,Benign,\N,intron_variant,0.446,0.4791,1KG_EUR_AF,OTOA
388812,16:21728130:T>A,NM_144672.3:c.1489-98T>A,\N,\N,13/27,Benign,\N,intron_variant,7.477,0.006,1KG_EAS_AF,OTOA
388813,16:21728143:A>G,NM_144672.3:c.1489-85A>G,\N,\N,13/27,Unknown significance,\N,intron_variant,5.355,\N,\N,OTOA
388814,16:21728161:C>T,NM_144672.3:c.1489-67C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,1.366,0.0023,1KG_AFR_AF,OTOA
388815,16:21728191:T>C,NM_144672.3:c.1489-37T>C,\N,\N,13/27,Unknown significance,\N,intron_variant,3.187,0.00015124,EXAC_FIN_AF,OTOA
388816,16:21728198:T>C,NM_144672.3:c.1489-30T>C,\N,\N,13/27,Unknown significance,\N,intron_variant,0.042,\N,\N,OTOA
388817,16:21728203:T>A,NM_144672.3:c.1489-25T>A,\N,\N,13/27,Unknown significance,\N,intron_variant,4.753,0.000172831,EXAC_AMR_AF,OTOA
388818,16:21728204:T>A,NM_144672.3:c.1489-24T>A,\N,\N,13/27,Unknown significance,\N,intron_variant,5.915,0.000604961,EXAC_FIN_AF,OTOA
388819,16:21728205:T>G,NM_144672.3:c.1489-23T>G,\N,\N,13/27,Unknown significance,\N,intron_variant,0.129,0.0000149948,EXAC_NFE_AF,OTOA
388820,16:21728206:T>C,NM_144672.3:c.1489-22T>C,\N,\N,13/27,Unknown significance,\N,intron_variant,2.2,0.0000963391,EXAC_AFR_AF,OTOA
388821,16:21728207:G>T,NM_144672.3:c.1489-21G>T,\N,\N,13/27,Unknown significance,\N,intron_variant,0.613,0.0000299913,EXAC_NFE_AF,OTOA
388822,16:21728214:C>T,NM_144672.3:c.1489-14C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,7.025,0.0025,OTO_JP_AF,OTOA
388823,16:21728216:C>G,NM_144672.3:c.1489-12C>G,\N,\N,13/27,Unknown significance,\N,intron_variant,1.568,0.000060562,EXAC_SAS_AF,OTOA
388824,16:21728217:G>A,NM_144672.3:c.1489-11G>A,\N,\N,13/27,Unknown significance,\N,intron_variant,1.617,0.000060562,EXAC_SAS_AF,OTOA
388825,16:21728217:G>T,NM_144672.3:c.1489-11G>T,\N,\N,13/27,Unknown significance,\N,intron_variant,0.715,0.000121124,EXAC_SAS_AF,OTOA
388826,16:21728218:C>T,NM_144672.3:c.1489-10C>T,\N,\N,13/27,Unknown significance,\N,intron_variant,4.944,0.000060562,EXAC_SAS_AF,OTOA
388827,16:21728219:T>A,NM_144672.3:c.1489-9T>A,\N,\N,13/27,Unknown significance,\N,intron_variant,7.843,0.0000149907,EXAC_NFE_AF,OTOA
388828,16:21728219:T>G,NM_144672.3:c.1489-9T>G,\N,\N,13/27,Unknown significance,\N,intron_variant,6.807,0.000060562,EXAC_SAS_AF,OTOA
388829,16:21728222:T>C,NM_144672.3:c.1489-6T>C,\N,\N,13/27,Unknown significance,\N,splice_region_variant&intron_variant,1.294,0.0000863856,EXAC_AMR_AF,OTOA
388830,16:21728228:A>G,NM_144672.3:c.1489A>G,NP_653273.3:p.Met497Val,14/28,\N,Likely benign,\N,missense_variant&splice_region_variant,0.001,0.000115554,EXAC_EAS_AF,OTOA
388831,16:21728230:G>A,NM_144672.3:c.1491G>A,NP_653273.3:p.Met497Ile,14/28,\N,Likely benign,\N,missense_variant&splice_region_variant,0.013,0.000116279,EVS_EA_AF,OTOA
388832,16:21728238:C>T,NM_001161683.1:c.1262C>T,NP_001155155.1:p.Ala421Val,10/24,\N,Likely benign,\N,missense_variant,5.839,0.001,1KG_EUR_AF,OTOA
388833,16:21728239:G>C,NM_144672.3:c.1500G>C,NP_653273.3:p.Ala500=,14/28,\N,Likely benign,\N,synonymous_variant,1.465,0.000484496,EXAC_SAS_AF,OTOA
388834,16:21728239:G>A,NM_144672.3:c.1500G>A,NP_653273.3:p.Ala500=,14/28,\N,Unknown significance,\N,synonymous_variant,5.15,0.00110375,EXAC_OTH_AF,OTOA
388835,16:21728245:C>T,NM_144672.3:c.1506C>T,NP_653273.3:p.Asp502=,14/28,\N,Unknown significance,\N,synonymous_variant,3.129,0.0000863707,EXAC_AMR_AF,OTOA
388836,16:21728260:C>T,NM_144672.3:c.1521C>T,NP_653273.3:p.Ile507=,14/28,\N,Unknown significance,\N,synonymous_variant,14.1,0.000576812,EXAC_AFR_AF,OTOA
388837,16:21728261:G>A,NM_144672.3:c.1522G>A,NP_653273.3:p.Val508Met,14/28,\N,Benign,\N,missense_variant,12.94,0.00710614,EXAC_FIN_AF,OTOA
388838,16:21728262:T>C,NM_144672.3:c.1523T>C,NP_653273.3:p.Val508Ala,14/28,\N,Benign,\N,missense_variant,0.21,0.0125,OTO_AJ_AF,OTOA
388839,16:21728269:A>T,NM_144672.3:c.1530A>T,NP_653273.3:p.Ile510=,14/28,\N,Unknown significance,\N,synonymous_variant,0.752,\N,\N,OTOA
388840,16:21728272:A>T,NM_144672.3:c.1533A>T,NP_653273.3:p.Gln511His,14/28,\N,Likely benign,\N,missense_variant,20.5,0.000259112,EXAC_AMR_AF,OTOA
388841,16:21728276:G>A,NM_170664.2:c.565G>A,NP_733764.1:p.Ala189Thr,5/19,\N,Likely benign,\N,missense_variant,11.43,0.000227376,EVS_AA_AF,OTOA
388842,16:21728276:G>T,NM_144672.3:c.1537G>T,NP_653273.3:p.Ala513Ser,14/28,\N,Likely benign,\N,missense_variant,8.445,0.0000149849,EXAC_NFE_AF,OTOA
388843,16:21728288:G>A,NM_144672.3:c.1549G>A,NP_653273.3:p.Glu517Lys,14/28,\N,Unknown significance,\N,missense_variant,25.8,0.000172741,EXAC_AMR_AF,OTOA
388844,16:21728299:C>T,NM_144672.3:c.1560C>T,NP_653273.3:p.Leu520=,14/28,\N,Unknown significance,\N,synonymous_variant,10.59,0.000060562,EXAC_SAS_AF,OTOA
388845,16:21728301:T>C,NM_144672.3:c.1562T>C,NP_653273.3:p.Phe521Ser,14/28,\N,Likely benign,\N,missense_variant,9.964,0.000116279,EVS_EA_AF,OTOA
388846,16:21728318:C>A,NM_144672.3:c.1579C>A,NP_653273.3:p.Pro527Thr,14/28,\N,Likely benign,\N,missense_variant,10.57,0.002,1KG_EUR_AF,OTOA
388847,16:21728322:G>T,NM_144672.3:c.1583G>T,NP_653273.3:p.Gly528Val,14/28,\N,Likely benign,\N,missense_variant,11.13,0.001,1KG_EAS_AF,OTOA
388848,16:21728326:C>A,NM_144672.3:c.1587C>A,NP_653273.3:p.Phe529Leu,14/28,\N,Likely benign,\N,missense_variant,20.2,0.000259112,EXAC_AMR_AF,OTOA
388849,16:21728329:C>T,NM_144672.3:c.1590C>T,NP_653273.3:p.Asn530=,14/28,\N,Unknown significance,\N,synonymous_variant,11.13,0.003,1KG_EAS_AF,OTOA
388850,16:21728334:C>T,NM_144672.3:c.1595C>T,NP_653273.3:p.Thr532Ile,14/28,\N,Unknown significance,\N,missense_variant,23.8,0.000172771,EXAC_AMR_AF,OTOA
388851,16:21728339:C>A,NM_144672.3:c.1600C>A,NP_653273.3:p.Leu534Met,14/28,\N,Likely benign,\N,missense_variant,22.8,0.0000962094,EXAC_AFR_AF,OTOA
388852,16:21728341:G>A,NM_144672.3:c.1602G>A,NP_653273.3:p.Leu534=,14/28,\N,Unknown significance,\N,synonymous_variant,11.28,0.0000863856,EXAC_AMR_AF,OTOA
388853,16:21728350:G>A,NM_144672.3:c.1611G>A,NP_653273.3:p.Lys537=,14/28,\N,Unknown significance,\N,synonymous_variant,11.52,0.0000149871,EXAC_NFE_AF,OTOA
388854,16:21728357:G>A,NM_144672.3:c.1618G>A,NP_653273.3:p.Gly540Arg,14/28,\N,Likely benign,\N,missense_variant,8.951,\N,\N,OTOA
388855,16:21728368:GGT>G,NM_144672.3:c.1629+1_1629+2del,\N,\N,14/27,Unknown significance,\N,splice_donor_variant,25,\N,\N,OTOA
388856,16:21728371:A>AAC,NM_144672.3:c.1629+3_1629+4insAC,\N,\N,14/27,Unknown significance,\N,splice_region_variant&intron_variant,0.109,\N,\N,OTOA
388857,16:21728372:T>C,NM_144672.3:c.1629+4T>C,\N,\N,14/27,Unknown significance,\N,splice_region_variant&intron_variant,0.044,0.0000149912,EXAC_NFE_AF,OTOA
388858,16:21728373:T>TGG,NM_144672.3:c.1629+5_1629+6insGG,\N,\N,14/27,Unknown significance,\N,splice_region_variant&intron_variant,0.378,\N,\N,OTOA
388859,16:21728374:ACC>A,NM_144672.3:c.1629+7_1629+8del,\N,\N,14/27,Unknown significance,\N,splice_region_variant&intron_variant,8.964,\N,\N,OTOA
388860,16:21728378:T>G,NM_144672.3:c.1629+10T>G,\N,\N,14/27,Unknown significance,\N,intron_variant,0.544,0.0000864454,EXAC_AMR_AF,OTOA
388861,16:21728383:C>T,NM_144672.3:c.1629+15C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,4.56,\N,\N,OTOA
388862,16:21728389:T>G,NM_144672.3:c.1629+21T>G,\N,\N,14/27,Unknown significance,\N,intron_variant,3.304,0.000172921,EXAC_AMR_AF,OTOA
388863,16:21728390:C>T,NM_144672.3:c.1629+22C>T,\N,\N,14/27,Benign,\N,intron_variant,0.031,0.1831,1KG_AFR_AF,OTOA
388864,16:21728391:G>A,NM_144672.3:c.1629+23G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,2.159,0.00277778,OTO_ES_AF,OTOA
388865,16:21728399:A>G,NM_144672.3:c.1629+31A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,10.71,\N,\N,OTOA
388866,16:21728406:A>C,NM_144672.3:c.1629+38A>C,\N,\N,14/27,Unknown significance,\N,intron_variant,11.57,0.0000150024,EXAC_NFE_AF,OTOA
388867,16:21728406:ACTAT>A,NM_144672.3:c.1629+41_1629+44del,\N,\N,14/27,Unknown significance,\N,intron_variant,14.18,0.0021207,EXAC_SAS_AF,OTOA
388868,16:21728407:C>G,NM_144672.3:c.1629+39C>G,\N,\N,14/27,Unknown significance,\N,intron_variant,12.36,0.000116306,EXAC_EAS_AF,OTOA
388869,16:21728409:A>G,NM_144672.3:c.1629+41A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,9.45,\N,\N,OTOA
388870,16:21728409:ATCTG>A,NM_144672.3:c.1629+45_1629+48del,\N,\N,14/27,Unknown significance,\N,intron_variant,14.07,0.0000150038,EXAC_NFE_AF,OTOA
388871,16:21728413:G>A,NM_144672.3:c.1629+45G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,13.51,0.0013655,EVS_AA_AF,OTOA
388872,16:21728420:G>C,NM_144672.3:c.1629+52G>C,\N,\N,14/27,Unknown significance,\N,intron_variant,14.31,0.0000150132,EXAC_NFE_AF,OTOA
388873,16:21728458:G>T,NM_144672.3:c.1629+90G>T,\N,\N,14/27,Unknown significance,\N,intron_variant,1.182,0.0041,1KG_SAS_AF,OTOA
388874,16:21728483:T>C,NM_144672.3:c.1629+115T>C,\N,\N,14/27,Unknown significance,\N,intron_variant,0.852,0.001,1KG_SAS_AF,OTOA
388875,16:21728512:T>C,NM_144672.3:c.1629+144T>C,\N,\N,14/27,Unknown significance,\N,intron_variant,0.574,\N,\N,OTOA
388876,16:21728516:G>A,NM_144672.3:c.1629+148G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,2.816,0.0015,1KG_AFR_AF,OTOA
388877,16:21728537:C>T,NM_144672.3:c.1629+169C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,7.119,0.0014,1KG_AMR_AF,OTOA
388878,16:21728538:G>A,NM_144672.3:c.1629+170G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,3.158,0.001,1KG_SAS_AF,OTOA
388879,16:21728545:G>A,NM_144672.3:c.1629+177G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,6.261,\N,\N,OTOA
388880,16:21728584:A>G,NM_144672.3:c.1629+216A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,4.896,0.001,1KG_EUR_AF,OTOA
388881,16:21728597:A>T,NM_144672.3:c.1629+229A>T,\N,\N,14/27,Unknown significance,\N,intron_variant,7.621,\N,\N,OTOA
388882,16:21728602:A>C,NM_144672.3:c.1629+234A>C,\N,\N,14/27,Unknown significance,\N,intron_variant,5.567,\N,\N,OTOA
388883,16:21728634:T>C,NM_144672.3:c.1629+266T>C,\N,\N,14/27,Unknown significance,\N,intron_variant,6.203,\N,\N,OTOA
388884,16:21728655:A>G,NM_144672.3:c.1629+287A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,9.624,0.0008,1KG_AFR_AF,OTOA
388885,16:21728673:G>A,NM_144672.3:c.1629+305G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,1.96,0.001,1KG_EUR_AF,OTOA
388886,16:21728682:A>G,NM_144672.3:c.1629+314A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,2.014,\N,\N,OTOA
388887,16:21728696:G>T,NM_144672.3:c.1629+328G>T,\N,\N,14/27,Unknown significance,\N,intron_variant,0.024,\N,\N,OTOA
388888,16:21728709:T>A,NM_144672.3:c.1629+341T>A,\N,\N,14/27,Unknown significance,\N,intron_variant,3.288,\N,\N,OTOA
388889,16:21728716:C>T,NM_144672.3:c.1629+348C>T,\N,\N,14/27,Benign,\N,intron_variant,0.197,0.0069,1KG_EAS_AF,OTOA
388890,16:21728740:C>T,NM_144672.3:c.1629+372C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,2.902,0.0015,1KG_AFR_AF,OTOA
388891,16:21728749:G>A,NM_144672.3:c.1629+381G>A,\N,\N,14/27,Benign,\N,intron_variant,1.077,0.0143,1KG_SAS_AF,OTOA
388892,16:21728763:T>TA,NM_144672.3:c.1629+404dup,\N,\N,14/27,Unknown significance,\N,intron_variant,4.526,\N,\N,OTOA
388893,16:21728825:G>C,NM_144672.3:c.1629+457G>C,\N,\N,14/27,Unknown significance,\N,intron_variant,9.708,0.001,1KG_SAS_AF,OTOA
388894,16:21728836:T>C,NM_144672.3:c.1629+468T>C,\N,\N,14/27,Unknown significance,\N,intron_variant,2.064,0.001,1KG_SAS_AF,OTOA
388895,16:21728861:C>T,NM_144672.3:c.1629+493C>T,\N,\N,14/27,Benign,\N,intron_variant,8.065,0.0099,1KG_EAS_AF,OTOA
388896,16:21728914:G>A,NM_144672.3:c.1629+546G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,2.28,\N,\N,OTOA
388897,16:21728915:G>C,NM_144672.3:c.1629+547G>C,\N,\N,14/27,Unknown significance,\N,intron_variant,1.352,0.0014,1KG_AMR_AF,OTOA
388898,16:21728937:C>T,NM_144672.3:c.1629+569C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,0.875,\N,\N,OTOA
388899,16:21728938:G>A,NM_144672.3:c.1629+570G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,0.081,0.0014,1KG_AMR_AF,OTOA
388900,16:21728978:C>A,NM_144672.3:c.1629+610C>A,\N,\N,14/27,Unknown significance,\N,intron_variant,1.446,0.001,1KG_SAS_AF,OTOA
388901,16:21728979:G>A,NM_144672.3:c.1629+611G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,0.244,0.001,1KG_SAS_AF,OTOA
388902,16:21728997:G>A,NM_144672.3:c.1629+629G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,1.389,0.003,1KG_AFR_AF,OTOA
388903,16:21729022:A>G,NM_144672.3:c.1629+654A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,3.565,\N,\N,OTOA
388904,16:21729062:C>T,NM_144672.3:c.1629+694C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,0.801,0.001,1KG_EAS_AF,OTOA
388905,16:21729068:T>C,NM_144672.3:c.1629+700T>C,\N,\N,14/27,Benign,\N,intron_variant,1.901,0.8658,1KG_EUR_AF,OTOA
388906,16:21729103:C>T,NM_144672.3:c.1629+735C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,1.634,\N,\N,OTOA
388907,16:21729133:C>G,NM_144672.3:c.1629+765C>G,\N,\N,14/27,Unknown significance,\N,intron_variant,1.496,0.0008,1KG_AFR_AF,OTOA
388908,16:21729148:C>T,NM_144672.3:c.1629+780C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,0.74,\N,\N,OTOA
388909,16:21729149:G>A,NM_144672.3:c.1629+781G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,3.052,\N,\N,OTOA
388910,16:21729159:C>T,NM_144672.3:c.1629+791C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,4.099,\N,\N,OTOA
388911,16:21729170:C>T,NM_144672.3:c.1629+802C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,0.461,0.001,1KG_EUR_AF,OTOA
388912,16:21729174:C>T,NM_144672.3:c.1629+806C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,1.63,0.001,1KG_SAS_AF,OTOA
388913,16:21729214:C>T,NM_144672.3:c.1629+846C>T,\N,\N,14/27,Benign,\N,intron_variant,1.034,0.8658,1KG_EUR_AF,OTOA
388914,16:21729259:A>G,NM_144672.3:c.1629+891A>G,\N,\N,14/27,Benign,\N,intron_variant,1.262,0.0174,1KG_AFR_AF,OTOA
388915,16:21729269:G>A,NM_144672.3:c.1629+901G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,0.053,\N,\N,OTOA
388916,16:21729308:C>A,NM_144672.3:c.1629+940C>A,\N,\N,14/27,Unknown significance,\N,intron_variant,2.904,\N,\N,OTOA
388917,16:21729313:G>A,NM_144672.3:c.1629+945G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,0.058,0.002,1KG_SAS_AF,OTOA
388918,16:21729333:AG>A,NM_144672.3:c.1629+966del,\N,\N,14/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388919,16:21729340:C>G,NM_144672.3:c.1629+972C>G,\N,\N,14/27,Unknown significance,\N,intron_variant,13.79,\N,\N,OTOA
388920,16:21729342:A>G,NM_144672.3:c.1629+974A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,15.17,0.0015,1KG_AFR_AF,OTOA
388921,16:21729349:C>T,NM_144672.3:c.1629+981C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,15.24,\N,\N,OTOA
388922,16:21729400:C>A,NM_144672.3:c.1629+1032C>A,\N,\N,14/27,Unknown significance,\N,intron_variant,2.436,0.001,1KG_EUR_AF,OTOA
388923,16:21729415:A>C,NM_144672.3:c.1630-1039A>C,\N,\N,14/27,Unknown significance,\N,intron_variant,0.553,0.0023,1KG_AFR_AF,OTOA
388924,16:21729420:A>T,NM_144672.3:c.1630-1034A>T,\N,\N,14/27,Unknown significance,\N,intron_variant,0.699,\N,\N,OTOA
388925,16:21729439:C>T,NM_144672.3:c.1630-1015C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,0.106,\N,\N,OTOA
388926,16:21729469:G>A,NM_144672.3:c.1630-985G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,2.516,0.0008,1KG_AFR_AF,OTOA
388927,16:21729510:C>T,NM_144672.3:c.1630-944C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,2.111,\N,\N,OTOA
388928,16:21729563:A>G,NM_144672.3:c.1630-891A>G,\N,\N,14/27,Benign,\N,intron_variant,4.521,0.005,1KG_EUR_AF,OTOA
388929,16:21729616:G>A,NM_144672.3:c.1630-838G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,5.391,0.001,1KG_EUR_AF,OTOA
388930,16:21729659:G>T,NM_144672.3:c.1630-795G>T,\N,\N,14/27,Benign,\N,intron_variant,6.554,0.0596,1KG_EUR_AF,OTOA
388931,16:21729677:G>A,NM_144672.3:c.1630-777G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,10.15,0.001,1KG_EUR_AF,OTOA
388932,16:21729691:G>T,NM_144672.3:c.1630-763G>T,\N,\N,14/27,Unknown significance,\N,intron_variant,11.03,\N,\N,OTOA
388933,16:21729762:C>T,NM_144672.3:c.1630-692C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,1.947,0.0014,1KG_AMR_AF,OTOA
388934,16:21729784:T>C,NM_144672.3:c.1630-670T>C,\N,\N,14/27,Unknown significance,\N,intron_variant,5.165,\N,\N,OTOA
388935,16:21729792:T>C,NM_144672.3:c.1630-662T>C,\N,\N,14/27,Unknown significance,\N,intron_variant,5.275,0.001,1KG_SAS_AF,OTOA
388936,16:21729839:T>G,NM_144672.3:c.1630-615T>G,\N,\N,14/27,Unknown significance,\N,intron_variant,17.92,0.001,1KG_EUR_AF,OTOA
388937,16:21729844:T>G,NM_144672.3:c.1630-610T>G,\N,\N,14/27,Unknown significance,\N,intron_variant,18.63,\N,\N,OTOA
388938,16:21729882:T>C,NM_144672.3:c.1630-572T>C,\N,\N,14/27,Unknown significance,\N,intron_variant,20.5,0.0008,1KG_AFR_AF,OTOA
388939,16:21729906:G>A,NM_144672.3:c.1630-548G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,13.93,0.0014,1KG_AMR_AF,OTOA
388940,16:21729916:T>C,NM_144672.3:c.1630-538T>C,\N,\N,14/27,Benign,\N,intron_variant,19.97,0.0212,1KG_AFR_AF,OTOA
388941,16:21729943:A>C,NM_144672.3:c.1630-511A>C,\N,\N,14/27,Unknown significance,\N,intron_variant,17.01,\N,\N,OTOA
388942,16:21729969:G>A,NM_144672.3:c.1630-485G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,2.283,\N,\N,OTOA
388943,16:21729990:T>C,NM_144672.3:c.1630-464T>C,\N,\N,14/27,Unknown significance,\N,intron_variant,4.55,\N,\N,OTOA
388944,16:21729991:T>TG,NM_144672.3:c.1630-457dup,\N,\N,14/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388945,16:21729993:G>C,NM_144672.3:c.1630-461G>C,\N,\N,14/27,Unknown significance,\N,intron_variant,7.664,0.001,1KG_EAS_AF,OTOA
388946,16:21729997:G>A,NM_144672.3:c.1630-457G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,8.406,0.0015,1KG_AFR_AF,OTOA
388947,16:21730010:A>G,NM_144672.3:c.1630-444A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,1.003,0.0029,1KG_AMR_AF,OTOA
388948,16:21730067:T>A,NM_144672.3:c.1630-387T>A,\N,\N,14/27,Unknown significance,\N,intron_variant,6.812,\N,\N,OTOA
388949,16:21730094:C>T,NM_144672.3:c.1630-360C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,2.44,\N,\N,OTOA
388950,16:21730115:T>C,NM_144672.3:c.1630-339T>C,\N,\N,14/27,Benign,\N,intron_variant,2.315,0.1989,1KG_AFR_AF,OTOA
388951,16:21730141:G>C,NM_144672.3:c.1630-313G>C,\N,\N,14/27,Unknown significance,\N,intron_variant,0.869,\N,\N,OTOA
388952,16:21730184:C>A,NM_144672.3:c.1630-270C>A,\N,\N,14/27,Unknown significance,\N,intron_variant,4.808,0.001,1KG_EUR_AF,OTOA
388953,16:21730189:A>T,NM_144672.3:c.1630-265A>T,\N,\N,14/27,Unknown significance,\N,intron_variant,0.538,0.001,1KG_SAS_AF,OTOA
388954,16:21730207:C>T,NM_144672.3:c.1630-247C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,2.084,\N,\N,OTOA
388955,16:21730236:G>C,NM_144672.3:c.1630-218G>C,\N,\N,14/27,Unknown significance,\N,intron_variant,1.226,0.002,1KG_EUR_AF,OTOA
388956,16:21730238:G>A,NM_144672.3:c.1630-216G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,2.811,0.001,1KG_EAS_AF,OTOA
388957,16:21730333:G>A,NM_144672.3:c.1630-121G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,3.88,0.0008,1KG_AFR_AF,OTOA
388958,16:21730356:G>A,NM_144672.3:c.1630-98G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,3.42,\N,\N,OTOA
388959,16:21730357:TA>T,NM_144672.3:c.1630-93del,\N,\N,14/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
388960,16:21730390:G>T,NM_144672.3:c.1630-64G>T,\N,\N,14/27,Unknown significance,\N,intron_variant,1.958,\N,\N,OTOA
388961,16:21730394:C>T,NM_144672.3:c.1630-60C>T,\N,\N,14/27,Benign,\N,intron_variant,3.727,0.0139,1KG_EAS_AF,OTOA
388962,16:21730403:G>A,NM_144672.3:c.1630-51G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,5.435,0.0000149948,EXAC_NFE_AF,OTOA
388963,16:21730405:G>A,NM_144672.3:c.1630-49G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,5.112,0.0000149925,EXAC_NFE_AF,OTOA
388964,16:21730410:C>T,NM_144672.3:c.1630-44C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,4.508,0.0000149912,EXAC_NFE_AF,OTOA
388965,16:21730411:G>A,NM_144672.3:c.1630-43G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,1.791,0.000121139,EXAC_SAS_AF,OTOA
388966,16:21730411:G>T,NM_144672.3:c.1630-43G>T,\N,\N,14/27,Unknown significance,\N,intron_variant,0.409,0.0000605694,EXAC_SAS_AF,OTOA
388967,16:21730423:A>G,NM_144672.3:c.1630-31A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,3.36,0.0000605694,EXAC_SAS_AF,OTOA
388968,16:21730424:T>A,NM_144672.3:c.1630-30T>A,\N,\N,14/27,Unknown significance,\N,intron_variant,6.261,0.0000299742,EXAC_NFE_AF,OTOA
388969,16:21730434:C>T,NM_144672.3:c.1630-20C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,0.983,0.00277778,OTO_ES_AF,OTOA
388970,16:21730435:G>A,NM_144672.3:c.1630-19G>A,\N,\N,14/27,Unknown significance,\N,intron_variant,0.535,0.000227376,EVS_AA_AF,OTOA
388971,16:21730436:A>G,NM_144672.3:c.1630-18A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,2.334,0.000347062,EXAC_EAS_AF,OTOA
388972,16:21730437:T>C,NM_144672.3:c.1630-17T>C,\N,\N,14/27,Unknown significance,\N,intron_variant,1.234,0.000347062,EXAC_EAS_AF,OTOA
388973,16:21730439:A>G,NM_144672.3:c.1630-15A>G,\N,\N,14/27,Unknown significance,\N,intron_variant,1.03,0.000192419,EXAC_AFR_AF,OTOA
388974,16:21730441:T>A,NM_144672.3:c.1630-13T>A,\N,\N,14/27,Unknown significance,\N,intron_variant,13.5,0.000864454,EXAC_AMR_AF,OTOA
388975,16:21730444:C>T,NM_144672.3:c.1630-10C>T,\N,\N,14/27,Unknown significance,\N,intron_variant,14.2,0.0000864454,EXAC_AMR_AF,OTOA
388976,16:21730449:C>T,NM_144672.3:c.1630-5C>T,\N,\N,14/27,Benign,\N,splice_region_variant&intron_variant,12.3,0.675886,EXAC_NFE_AF,OTOA
388977,16:21730450:G>A,NM_144672.3:c.1630-4G>A,\N,\N,14/27,Unknown significance,\N,splice_region_variant&intron_variant,9.727,0.0008,1KG_AFR_AF,OTOA
388978,16:21730451:C>A,NM_144672.3:c.1630-3C>A,\N,\N,14/27,Unknown significance,\N,splice_region_variant&intron_variant,14.67,\N,\N,OTOA
388979,16:21730457:C>T,NM_144672.3:c.1633C>T,NP_653273.3:p.Leu545=,15/28,\N,Unknown significance,\N,synonymous_variant,10.33,0.0000864304,EXAC_AMR_AF,OTOA
388980,16:21730464:T>G,NM_144672.3:c.1640T>G,NP_653273.3:p.Leu547Arg,15/28,\N,Unknown significance,\N,missense_variant,28.8,0.0000149844,EXAC_NFE_AF,OTOA
388981,16:21730467:A>G,NM_144672.3:c.1643A>G,NP_653273.3:p.Tyr548Cys,15/28,\N,Unknown significance,\N,missense_variant,26,0.000060562,EXAC_SAS_AF,OTOA
388982,16:21730472:C>T,NM_144672.3:c.1648C>T,NP_653273.3:p.Leu550Phe,15/28,\N,Likely benign,\N,missense_variant,19.59,0.0000149849,EXAC_NFE_AF,OTOA
388983,16:21730473:T>G,NM_144672.3:c.1649T>G,NP_653273.3:p.Leu550Arg,15/28,\N,Unknown significance,\N,missense_variant,23.2,0.0000149849,EXAC_NFE_AF,OTOA
388984,16:21730475:C>T,NM_144672.3:c.1651C>T,NP_653273.3:p.Leu551=,15/28,\N,Unknown significance,\N,synonymous_variant,15.19,0.0008,1KG_AFR_AF,OTOA
388985,16:21730486:C>T,NM_144672.3:c.1662C>T,NP_653273.3:p.Thr554=,15/28,\N,Unknown significance,\N,synonymous_variant,12.54,0.0000299706,EXAC_NFE_AF,OTOA
388986,16:21730506:T>C,NM_144672.3:c.1682T>C,NP_653273.3:p.Leu561Pro,15/28,\N,Unknown significance,\N,missense_variant,26.7,0.0000605694,EXAC_SAS_AF,OTOA
388987,16:21730513:G>T,NM_144672.3:c.1688+1G>T,\N,\N,15/27,Pathogenic,Deafness| autosomal recessive 22,splice_donor_variant,23.9,0.0000605914,EXAC_SAS_AF,OTOA
388988,16:21730514:T>C,NM_144672.3:c.1688+2T>C,\N,\N,15/27,Unknown significance,\N,splice_donor_variant,23.6,0.0000149907,EXAC_NFE_AF,OTOA
388989,16:21730525:A>G,NM_144672.3:c.1688+13A>G,\N,\N,15/27,Unknown significance,\N,intron_variant,2.01,0.000227376,EVS_AA_AF,OTOA
388990,16:21730527:C>T,NM_144672.3:c.1688+15C>T,\N,\N,15/27,Unknown significance,\N,intron_variant,2.579,0.003,1KG_AFR_AF,OTOA
388991,16:21730529:C>T,NM_144672.3:c.1688+17C>T,\N,\N,15/27,Unknown significance,\N,intron_variant,0.444,0.00110375,EXAC_OTH_AF,OTOA
388992,16:21730530:G>C,NM_144672.3:c.1688+18G>C,\N,\N,15/27,Unknown significance,\N,intron_variant,0.005,0.000116523,EXAC_EAS_AF,OTOA
388993,16:21730535:G>A,NM_144672.3:c.1688+23G>A,\N,\N,15/27,Unknown significance,\N,intron_variant,5.401,0.000116279,EVS_EA_AF,OTOA
388994,16:21730544:A>G,NM_144672.3:c.1688+32A>G,\N,\N,15/27,Unknown significance,\N,intron_variant,4.065,0.000182017,EXAC_SAS_AF,OTOA
388995,16:21730548:G>T,NM_144672.3:c.1688+36G>T,\N,\N,15/27,Unknown significance,\N,intron_variant,1.826,0.000121389,EXAC_SAS_AF,OTOA
388996,16:21730549:C>T,NM_144672.3:c.1688+37C>T,\N,\N,15/27,Unknown significance,\N,intron_variant,5.821,0.000930233,EVS_EA_AF,OTOA
388997,16:21730592:G>GA,NM_144672.3:c.1688+81dup,\N,\N,15/27,Unknown significance,\N,intron_variant,10.54,\N,\N,OTOA
388998,16:21730611:C>A,NM_144672.3:c.1689-97C>A,\N,\N,15/27,Unknown significance,\N,intron_variant,6.623,0.0031,1KG_SAS_AF,OTOA
388999,16:21730614:T>C,NM_144672.3:c.1689-94T>C,\N,\N,15/27,Unknown significance,\N,intron_variant,4.376,\N,\N,OTOA
389000,16:21730646:G>A,NM_144672.3:c.1689-62G>A,\N,\N,15/27,Benign,\N,intron_variant,8.028,0.0123,1KG_SAS_AF,OTOA
389001,16:21730657:C>T,NM_144672.3:c.1689-51C>T,\N,\N,15/27,Unknown significance,\N,intron_variant,5.104,0.0000158584,EXAC_NFE_AF,OTOA
389002,16:21730658:C>T,NM_144672.3:c.1689-50C>T,\N,\N,15/27,Unknown significance,\N,intron_variant,5.995,0.000116279,EVS_EA_AF,OTOA
389003,16:21730663:C>T,NM_144672.3:c.1689-45C>T,\N,\N,15/27,Unknown significance,\N,intron_variant,5.061,0.000127033,EXAC_EAS_AF,OTOA
389004,16:21730668:C>T,NM_144672.3:c.1689-40C>T,\N,\N,15/27,Unknown significance,\N,intron_variant,2.318,0.000227376,EVS_AA_AF,OTOA
389005,16:21730680:C>T,NM_144672.3:c.1689-28C>T,\N,\N,15/27,Unknown significance,\N,intron_variant,6.804,0.0000984446,EXAC_AFR_AF,OTOA
389006,16:21730684:C>T,NM_144672.3:c.1689-24C>T,\N,\N,15/27,Unknown significance,\N,intron_variant,0.972,0.000227376,EVS_AA_AF,OTOA
389007,16:21730685:G>A,NM_144672.3:c.1689-23G>A,\N,\N,15/27,Unknown significance,\N,intron_variant,4.983,0.0000979624,EXAC_AFR_AF,OTOA
389008,16:21730685:G>T,NM_144672.3:c.1689-23G>T,\N,\N,15/27,Unknown significance,\N,intron_variant,3.11,0.0000154943,EXAC_NFE_AF,OTOA
389009,16:21730686:A>C,NM_144672.3:c.1689-22A>C,\N,\N,15/27,Unknown significance,\N,intron_variant,4.124,0.0000309052,EXAC_NFE_AF,OTOA
389010,16:21730688:T>C,NM_144672.3:c.1689-20T>C,\N,\N,15/27,Unknown significance,\N,intron_variant,1.54,\N,\N,OTOA
389011,16:21730690:C>A,NM_144672.3:c.1689-18C>A,\N,\N,15/27,Unknown significance,\N,intron_variant,4.383,0.000454752,EVS_AA_AF,OTOA
389012,16:21730691:CTTGTT>C,NM_144672.3:c.1689-9_1689-5del,\N,\N,15/27,Unknown significance,\N,intron_variant,18.22,0.000214238,EXAC_NFE_AF,OTOA
389013,16:21730699:G>C,NM_144672.3:c.1689-9G>C,\N,\N,15/27,Unknown significance,\N,intron_variant,15.53,0.000227376,EVS_AA_AF,OTOA
389014,16:21730704:C>T,NM_144672.3:c.1689-4C>T,\N,\N,15/27,Unknown significance,\N,splice_region_variant&intron_variant,14.37,\N,\N,OTOA
389015,16:21730706:A>T,NM_144672.3:c.1689-2A>T,\N,\N,15/27,Unknown significance,\N,splice_acceptor_variant,23.7,\N,\N,OTOA
389016,16:21730729:C>T,NM_144672.3:c.1710C>T,NP_653273.3:p.Gly570=,16/28,\N,Benign,\N,synonymous_variant,17.63,0.009375,OTO_US_AF,OTOA
389017,16:21730730:G>A,NM_144672.3:c.1711G>A,NP_653273.3:p.Val571Met,16/28,\N,Unknown significance,\N,missense_variant,19.13,0.0008,1KG_AFR_AF,OTOA
389018,16:21730732:G>A,NM_144672.3:c.1713G>A,NP_653273.3:p.Val571=,16/28,\N,Unknown significance,\N,synonymous_variant,11.85,0.0000299994,EXAC_NFE_AF,OTOA
389019,16:21730738:C>T,NM_144672.3:c.1719C>T,NP_653273.3:p.Cys573=,16/28,\N,Unknown significance,\N,synonymous_variant,13.62,0.0000299832,EXAC_NFE_AF,OTOA
389020,16:21730743:A>C,NM_144672.3:c.1724A>C,NP_653273.3:p.His575Pro,16/28,\N,Unknown significance,\N,missense_variant,25.1,0.000116279,EVS_EA_AF,OTOA
389021,16:21730745:A>T,NM_144672.3:c.1726A>T,NP_653273.3:p.Ile576Phe,16/28,\N,Unknown significance,\N,missense_variant,20.6,0.0000149871,EXAC_NFE_AF,OTOA
389022,16:21730746:T>C,NM_144672.3:c.1727T>C,NP_653273.3:p.Ile576Thr,16/28,\N,Unknown significance,\N,missense_variant,26.4,0.000242277,EXAC_SAS_AF,OTOA
389023,16:21730747:T>G,NM_144672.3:c.1728T>G,NP_653273.3:p.Ile576Met,16/28,\N,Unknown significance,\N,missense_variant,23.8,0.000454752,EVS_AA_AF,OTOA
389024,16:21730748:G>A,NM_001161683.1:c.1492G>A,NP_001155155.1:p.Asp498Asn,12/24,\N,Unknown significance,\N,missense_variant,24,0.000227376,EVS_AA_AF,OTOA
389025,16:21730768:C>A,NM_144672.3:c.1749C>A,NP_653273.3:p.Phe583Leu,16/28,\N,Likely benign,\N,missense_variant,9.697,0.0000961169,EXAC_AFR_AF,OTOA
389026,16:21730772:C>G,NM_144672.3:c.1753C>G,NP_653273.3:p.Leu585Val,16/28,\N,Unknown significance,\N,missense_variant,16.6,0.000227376,EVS_AA_AF,OTOA
389027,16:21730776:C>G,NM_144672.3:c.1757C>G,NP_653273.3:p.Ala586Gly,16/28,\N,Likely benign,\N,missense_variant,15.38,0.00011558,EXAC_EAS_AF,OTOA
389028,16:21730782:TC>T,NM_144672.3:c.1765del,NP_653273.3:p.Gln589ArgfsTer55,16/28,\N,Likely pathogenic,Hearing loss,frameshift_variant,31,0.000346661,EXAC_EAS_AF,OTOA
389029,16:21730787:G>C,NM_144672.3:c.1768G>C,NP_653273.3:p.Asp590His,16/28,\N,Likely benign,\N,missense_variant,1.677,0.000014984,EXAC_NFE_AF,OTOA
389030,16:21730792:T>G,NM_144672.3:c.1773T>G,NP_653273.3:p.Phe591Leu,16/28,\N,Unknown significance,\N,missense_variant,21.5,0.0000299679,EXAC_NFE_AF,OTOA
389031,16:21730799:A>G,NM_144672.3:c.1780A>G,NP_653273.3:p.Asn594Asp,16/28,\N,Unknown significance,\N,missense_variant,22.1,0.000060562,EXAC_SAS_AF,OTOA
389032,16:21730804:C>T,NM_144672.3:c.1785C>T,NP_653273.3:p.Phe595=,16/28,\N,Unknown significance,\N,synonymous_variant,10.56,0.000060562,EXAC_SAS_AF,OTOA
389033,16:21730805:G>A,NM_144672.3:c.1786G>A,NP_653273.3:p.Ala596Thr,16/28,\N,Likely benign,\N,missense_variant,2.344,0.0000863856,EXAC_AMR_AF,OTOA
389034,16:21730810:G>A,NM_144672.3:c.1791G>A,NP_653273.3:p.Leu597=,16/28,\N,Unknown significance,\N,synonymous_variant,7.731,0.000116279,EVS_EA_AF,OTOA
389035,16:21730810:G>T,NM_144672.3:c.1791G>T,NP_653273.3:p.Leu597=,16/28,\N,Unknown significance,\N,synonymous_variant,5.004,0.0000299679,EXAC_NFE_AF,OTOA
389036,16:21730811:C>T,NM_144672.3:c.1792C>T,NP_653273.3:p.Leu598Phe,16/28,\N,Unknown significance,\N,missense_variant,28.1,0.0000299679,EXAC_NFE_AF,OTOA
389037,16:21730815:C>T,NM_144672.3:c.1796C>T,NP_653273.3:p.Ser599Leu,16/28,\N,Unknown significance,\N,missense_variant,32,\N,\N,OTOA
389038,16:21730827:T>TA,NM_144672.3:c.1806+3dup,\N,\N,16/27,Unknown significance,\N,splice_region_variant&intron_variant,14.45,0.000960984,EXAC_AFR_AF,OTOA
389039,16:21730829:C>A,NM_144672.3:c.1806+4C>A,\N,\N,16/27,Unknown significance,\N,splice_region_variant&intron_variant,13.97,0.000232558,EVS_EA_AF,OTOA
389040,16:21730830:C>T,NM_144672.3:c.1806+5C>T,\N,\N,16/27,Unknown significance,\N,splice_region_variant&intron_variant,7.664,0.001,1KG_EAS_AF,OTOA
389041,16:21730836:A>G,NM_144672.3:c.1806+11A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,3.72,0.000014984,EXAC_NFE_AF,OTOA
389042,16:21730837:G>C,NM_144672.3:c.1806+12G>C,\N,\N,16/27,Unknown significance,\N,intron_variant,1.67,0.000014984,EXAC_NFE_AF,OTOA
389043,16:21730837:G>T,NM_144672.3:c.1806+12G>T,\N,\N,16/27,Unknown significance,\N,intron_variant,2.877,0.000227376,EVS_AA_AF,OTOA
389044,16:21730839:A>AT,NM_144672.3:c.1806+18dup,\N,\N,16/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389045,16:21730854:A>G,NM_144672.3:c.1806+29A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,5.207,0.0000149844,EXAC_NFE_AF,OTOA
389046,16:21730857:C>A,NM_144672.3:c.1806+32C>A,\N,\N,16/27,Unknown significance,\N,intron_variant,5.514,0.0000149849,EXAC_NFE_AF,OTOA
389047,16:21730866:T>C,NM_144672.3:c.1806+41T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,4.025,0.0000149853,EXAC_NFE_AF,OTOA
389048,16:21730868:C>T,NM_144672.3:c.1806+43C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,5.441,0.0014,1KG_AMR_AF,OTOA
389049,16:21730869:C>G,NM_144672.3:c.1806+44C>G,\N,\N,16/27,Unknown significance,\N,intron_variant,4.382,0.000346741,EXAC_EAS_AF,OTOA
389050,16:21730925:T>C,NM_144672.3:c.1806+100T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,1.254,0.0008,1KG_AFR_AF,OTOA
389051,16:21730931:C>T,NM_144672.3:c.1806+106C>T,\N,\N,16/27,Benign,\N,intron_variant,1.526,0.0106,1KG_AFR_AF,OTOA
389052,16:21730932:G>C,NM_144672.3:c.1806+107G>C,\N,\N,16/27,Unknown significance,\N,intron_variant,0.318,0.001,1KG_SAS_AF,OTOA
389053,16:21730964:A>G,NM_144672.3:c.1806+139A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,17.23,\N,\N,OTOA
389054,16:21730966:G>A,NM_144672.3:c.1806+141G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,18.99,0.001,1KG_EAS_AF,OTOA
389055,16:21731013:C>A,NM_144672.3:c.1806+188C>A,\N,\N,16/27,Unknown significance,\N,intron_variant,6.712,\N,\N,OTOA
389056,16:21731013:C>T,NM_144672.3:c.1806+188C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,6.098,\N,\N,OTOA
389057,16:21731021:G>T,NM_144672.3:c.1806+196G>T,\N,\N,16/27,Benign,\N,intron_variant,3.716,0.0091,1KG_AFR_AF,OTOA
389058,16:21731027:A>G,NM_144672.3:c.1806+202A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,5.003,0.0008,1KG_AFR_AF,OTOA
389059,16:21731039:T>C,NM_144672.3:c.1806+214T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,1.035,\N,\N,OTOA
389060,16:21731058:C>A,NM_144672.3:c.1806+233C>A,\N,\N,16/27,Unknown significance,\N,intron_variant,5.841,0.0014,1KG_AMR_AF,OTOA
389061,16:21731105:T>G,NM_144672.3:c.1806+280T>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.283,0.001,1KG_EUR_AF,OTOA
389062,16:21731120:G>A,NM_144672.3:c.1806+295G>A,\N,\N,16/27,Benign,\N,intron_variant,1.322,0.1646,1KG_SAS_AF,OTOA
389063,16:21731197:CT>C,NM_144672.3:c.1806+375del,\N,\N,16/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389064,16:21731198:T>C,NM_144672.3:c.1806+373T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,2.411,0.001,1KG_EAS_AF|1KG_SAS_AF,OTOA
389065,16:21731246:C>G,NM_144672.3:c.1806+421C>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.714,0.001,1KG_SAS_AF,OTOA
389066,16:21731278:C>CT,NM_144672.3:c.1806+469dup,\N,\N,16/27,Unknown significance,\N,intron_variant,3.501,\N,\N,OTOA
389067,16:21731278:C>T,NM_144672.3:c.1806+453C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,0.605,\N,\N,OTOA
389068,16:21731388:C>T,NM_144672.3:c.1806+563C>T,\N,\N,16/27,Benign,\N,intron_variant,1.002,0.0109,1KG_EUR_AF,OTOA
389069,16:21731436:C>T,NM_144672.3:c.1806+611C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,3.572,0.001,1KG_EAS_AF,OTOA
389070,16:21731465:T>C,NM_144672.3:c.1806+640T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,1.38,\N,\N,OTOA
389071,16:21731468:G>A,NM_144672.3:c.1806+643G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,3.554,\N,\N,OTOA
389072,16:21731515:G>C,NM_144672.3:c.1806+690G>C,\N,\N,16/27,Benign,\N,intron_variant,4.795,0.0099,1KG_EUR_AF,OTOA
389073,16:21731545:G>A,NM_144672.3:c.1806+720G>A,\N,\N,16/27,Benign,\N,intron_variant,8.171,0.093,1KG_AFR_AF,OTOA
389074,16:21731594:T>A,NM_144672.3:c.1806+769T>A,\N,\N,16/27,Unknown significance,\N,intron_variant,0.431,\N,\N,OTOA
389075,16:21731720:T>A,NM_144672.3:c.1806+895T>A,\N,\N,16/27,Unknown significance,\N,intron_variant,6.052,0.002,1KG_EAS_AF,OTOA
389076,16:21731757:C>G,NM_144672.3:c.1806+932C>G,\N,\N,16/27,Unknown significance,\N,intron_variant,0.978,0.002,1KG_EAS_AF,OTOA
389077,16:21731774:C>T,NM_144672.3:c.1806+949C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,5.518,0.001,1KG_EAS_AF,OTOA
389078,16:21731820:T>C,NM_144672.3:c.1806+995T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,2.33,\N,\N,OTOA
389079,16:21731861:G>C,NM_144672.3:c.1806+1036G>C,\N,\N,16/27,Unknown significance,\N,intron_variant,2.103,\N,\N,OTOA
389080,16:21731892:T>G,NM_144672.3:c.1806+1067T>G,\N,\N,16/27,Unknown significance,\N,intron_variant,9.284,\N,\N,OTOA
389081,16:21731972:T>C,NM_144672.3:c.1806+1147T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,3.519,0.001,1KG_SAS_AF,OTOA
389082,16:21732095:A>C,NM_144672.3:c.1806+1270A>C,\N,\N,16/27,Unknown significance,\N,intron_variant,1.034,\N,\N,OTOA
389083,16:21732120:C>G,NM_144672.3:c.1806+1295C>G,\N,\N,16/27,Unknown significance,\N,intron_variant,2.653,\N,\N,OTOA
389084,16:21732126:AAGGTGCTTTCCT>A,NM_144672.3:c.1806+1305_1806+1316del,\N,\N,16/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389085,16:21732195:C>T,NM_144672.3:c.1806+1370C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,3.048,\N,\N,OTOA
389086,16:21732211:A>G,NM_144672.3:c.1806+1386A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,3.975,0.003,1KG_EUR_AF,OTOA
389087,16:21732217:C>CATT,NM_144672.3:c.1806+1416_1806+1418dup,\N,\N,16/27,Unknown significance,\N,intron_variant,4.25,\N,\N,OTOA
389088,16:21732217:C>CATTATT,NM_144672.3:c.1806+1413_1806+1418dup,\N,\N,16/27,Unknown significance,\N,intron_variant,3.731,0.0043,1KG_AMR_AF,OTOA
389089,16:21732217:C>CATTATTATT,NM_144672.3:c.1806+1410_1806+1418dup,\N,\N,16/27,Unknown significance,\N,intron_variant,3.22,\N,\N,OTOA
389090,16:21732217:C>CATTATTATTATTATT,NM_144672.3:c.1806+1404_1806+1418dup,\N,\N,16/27,Benign,\N,intron_variant,2.278,0.2366,1KG_EUR_AF,OTOA
389091,16:21732217:CATT>C,NM_144672.3:c.1806+1416_1806+1418del,\N,\N,16/27,Unknown significance,\N,intron_variant,7.46,\N,\N,OTOA
389092,16:21732238:T>C,NM_144672.3:c.1806+1413T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,1.32,\N,\N,OTOA
389093,16:21732244:C>T,NM_144672.3:c.1806+1419C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,1.708,\N,\N,OTOA
389094,16:21732280:TG>CA,NM_144672.3:c.1806+1455_1806+1456inv,\N,\N,16/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389095,16:21732315:C>A,NM_144672.3:c.1806+1490C>A,\N,\N,16/27,Benign,\N,intron_variant,2.504,0.0577,1KG_EUR_AF,OTOA
389096,16:21732323:G>A,NM_144672.3:c.1806+1498G>A,\N,\N,16/27,Benign,\N,intron_variant,0.07,0.0348,1KG_AFR_AF,OTOA
389097,16:21732326:C>A,NM_144672.3:c.1806+1501C>A,\N,\N,16/27,Unknown significance,\N,intron_variant,2.171,0.0023,1KG_AFR_AF,OTOA
389098,16:21732377:A>C,NM_144672.3:c.1806+1552A>C,\N,\N,16/27,Unknown significance,\N,intron_variant,1.351,\N,\N,OTOA
389099,16:21732382:C>T,NM_144672.3:c.1806+1557C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,0.413,0.0008,1KG_AFR_AF,OTOA
389100,16:21732424:C>T,NM_144672.3:c.1806+1599C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,0.081,0.001,1KG_SAS_AF,OTOA
389101,16:21732439:T>A,NM_144672.3:c.1806+1614T>A,\N,\N,16/27,Unknown significance,\N,intron_variant,3.465,0.0008,1KG_AFR_AF,OTOA
389102,16:21732456:G>T,NM_144672.3:c.1806+1631G>T,\N,\N,16/27,Benign,\N,intron_variant,0.021,0.1646,1KG_SAS_AF,OTOA
389103,16:21732460:T>C,NM_144672.3:c.1806+1635T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,2.366,\N,\N,OTOA
389104,16:21732489:G>A,NM_144672.3:c.1806+1664G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,10.97,\N,\N,OTOA
389105,16:21732503:T>C,NM_144672.3:c.1806+1678T>C,\N,\N,16/27,Benign,\N,intron_variant,10.12,0.1203,1KG_AFR_AF,OTOA
389106,16:21732528:G>A,NM_144672.3:c.1807-1698G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,1.236,\N,\N,OTOA
389107,16:21732532:A>T,NM_144672.3:c.1807-1694A>T,\N,\N,16/27,Benign,\N,intron_variant,1.647,0.0149,1KG_EAS_AF,OTOA
389108,16:21732553:TAC>T,NM_144672.3:c.1807-1627_1807-1626del,\N,\N,16/27,Benign,\N,intron_variant,8.631,0.8767,1KG_AFR_AF,OTOA
389109,16:21732553:TACAC>T,NM_144672.3:c.1807-1629_1807-1626del,\N,\N,16/27,Unknown significance,\N,intron_variant,8.431,\N,\N,OTOA
389110,16:21732575:C>T,NM_144672.3:c.1807-1651C>T,\N,\N,16/27,Benign,\N,intron_variant,3.537,0.1646,1KG_SAS_AF,OTOA
389111,16:21732593:CACACACAA>C,NM_144672.3:c.1807-1629_1807-1622del,\N,\N,16/27,Unknown significance,\N,intron_variant,8.183,\N,\N,OTOA
389112,16:21732595:CACACAA>C,NM_144672.3:c.1807-1627_1807-1622del,\N,\N,16/27,Unknown significance,\N,intron_variant,8.402,\N,\N,OTOA
389113,16:21732597:C>T,NM_144672.3:c.1807-1629C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,3.621,\N,\N,OTOA
389114,16:21732597:CACAA>C,NM_144672.3:c.1807-1624_1807-1621del,\N,\N,16/27,Unknown significance,\N,intron_variant,8.599,\N,\N,OTOA
389115,16:21732601:A>C,NM_144672.3:c.1807-1625A>C,\N,\N,16/27,Benign,\N,intron_variant,0.442,0.0605,1KG_AMR_AF,OTOA
389116,16:21732604:AAC>A,NM_144672.3:c.1807-1621_1807-1620del,\N,\N,16/27,Unknown significance,\N,intron_variant,0.561,\N,\N,OTOA
389117,16:21732605:A>C,NM_144672.3:c.1807-1621A>C,\N,\N,16/27,Unknown significance,\N,intron_variant,3.291,\N,\N,OTOA
389118,16:21732606:C>A,NM_144672.3:c.1807-1620C>A,\N,\N,16/27,Unknown significance,\N,intron_variant,4.492,\N,\N,OTOA
389119,16:21732636:T>A,NM_144672.3:c.1807-1590T>A,\N,\N,16/27,Unknown significance,\N,intron_variant,9.354,0.0008,1KG_AFR_AF,OTOA
389120,16:21732667:A>G,NM_144672.3:c.1807-1559A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.849,\N,\N,OTOA
389121,16:21732669:T>A,NM_144672.3:c.1807-1557T>A,\N,\N,16/27,Unknown significance,\N,intron_variant,3.101,0.000266454,EXAC_SAS_AF,OTOA
389122,16:21732688:AC>A,NM_144672.3:c.1807-1537del,\N,\N,16/27,Unknown significance,\N,intron_variant,4.521,\N,\N,OTOA
389123,16:21732689:C>T,NM_144672.3:c.1807-1537C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,8.601,0.0008,1KG_AFR_AF,OTOA
389124,16:21732692:T>A,NM_144672.3:c.1807-1534T>A,\N,\N,16/27,Unknown significance,\N,intron_variant,9.121,\N,\N,OTOA
389125,16:21732697:C>T,NM_144672.3:c.1807-1529C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,8.481,0.000133227,EXAC_SAS_AF,OTOA
389126,16:21732705:CA>C,NM_144672.3:c.1807-1518del,\N,\N,16/27,Unknown significance,\N,intron_variant,7.526,0.000133227,EXAC_SAS_AF,OTOA
389127,16:21732716:G>T,NM_144672.3:c.1807-1510G>T,\N,\N,16/27,Unknown significance,\N,intron_variant,1.635,0.000133227,EXAC_SAS_AF,OTOA
389128,16:21732728:C>T,NM_144672.3:c.1807-1498C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,2.443,0.001,1KG_SAS_AF,OTOA
389129,16:21732729:G>A,NM_144672.3:c.1807-1497G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,2.952,0.0023,1KG_AFR_AF,OTOA
389130,16:21732738:C>T,NM_144672.3:c.1807-1488C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,3.917,0.0015,1KG_AFR_AF,OTOA
389131,16:21732763:C>T,NM_144672.3:c.1807-1463C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,6.413,\N,\N,OTOA
389132,16:21732766:G>A,NM_144672.3:c.1807-1460G>A,\N,\N,16/27,Benign,\N,intron_variant,2.182,0.00847458,EXAC_OTH_AF,OTOA
389133,16:21732788:A>G,NM_144672.3:c.1807-1438A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,3.326,0.000133227,EXAC_SAS_AF,OTOA
389134,16:21732791:C>T,NM_144672.3:c.1807-1435C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,4.786,0.001,1KG_EAS_AF,OTOA
389135,16:21732796:G>A,NM_144672.3:c.1807-1430G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,3.21,0.000366838,EXAC_NFE_AF,OTOA
389136,16:21732823:G>A,NM_144672.3:c.1807-1403G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,3.817,0.000133227,EXAC_SAS_AF,OTOA
389137,16:21732825:C>G,NM_144672.3:c.1807-1401C>G,\N,\N,16/27,Unknown significance,\N,intron_variant,4.349,0.000133227,EXAC_SAS_AF,OTOA
389138,16:21732826:G>A,NM_144672.3:c.1807-1400G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,1.645,0.000133262,EXAC_SAS_AF,OTOA
389139,16:21732833:T>A,NM_144672.3:c.1807-1393T>A,\N,\N,16/27,Unknown significance,\N,intron_variant,3.875,0.001,1KG_EAS_AF,OTOA
389140,16:21732836:A>G,NM_144672.3:c.1807-1390A>G,\N,\N,16/27,Benign,\N,intron_variant,2.477,0.5,EXAC_FIN_AF,OTOA
389141,16:21732848:T>G,NM_144672.3:c.1807-1378T>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.105,0.000266809,EXAC_SAS_AF,OTOA
389142,16:21732853:A>G,NM_144672.3:c.1807-1373A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,2.146,0.0014,1KG_AMR_AF,OTOA
389143,16:21732855:C>G,NM_144672.3:c.1807-1371C>G,\N,\N,16/27,Unknown significance,\N,intron_variant,2.953,0.0014,1KG_AMR_AF,OTOA
389144,16:21732857:G>A,NM_144672.3:c.1807-1369G>A,\N,\N,16/27,Benign,\N,intron_variant,0.419,0.0106383,EXAC_AFR_AF,OTOA
389145,16:21732860:T>C,NM_144672.3:c.1807-1366T>C,\N,\N,16/27,Benign,\N,intron_variant,0.467,0.00862069,EXAC_OTH_AF,OTOA
389146,16:21732870:A>G,NM_144672.3:c.1807-1356A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,5.048,0.000133905,EXAC_SAS_AF,OTOA
389147,16:21732886:T>C,NM_144672.3:c.1807-1340T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,4.963,0.0031,1KG_SAS_AF,OTOA
389148,16:21732894:A>G,NM_144672.3:c.1807-1332A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.315,\N,\N,OTOA
389149,16:21732902:G>T,NM_144672.3:c.1807-1324G>T,\N,\N,16/27,Unknown significance,\N,intron_variant,0.283,\N,\N,OTOA
389150,16:21732909:C>G,NM_144672.3:c.1807-1317C>G,\N,\N,16/27,Unknown significance,\N,intron_variant,0.242,0.001,1KG_SAS_AF,OTOA
389151,16:21732929:G>A,NM_144672.3:c.1807-1297G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,1.172,\N,\N,OTOA
389152,16:21733054:A>G,NM_144672.3:c.1807-1172A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,0.195,\N,\N,OTOA
389153,16:21733088:C>A,NM_144672.3:c.1807-1138C>A,\N,\N,16/27,Benign,\N,intron_variant,0.553,0.0098,1KG_AFR_AF,OTOA
389154,16:21733096:C>T,NM_144672.3:c.1807-1130C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,3.52,0.001,1KG_EAS_AF,OTOA
389155,16:21733121:G>A,NM_144672.3:c.1807-1105G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,4.88,\N,\N,OTOA
389156,16:21733137:T>C,NM_144672.3:c.1807-1089T>C,\N,\N,16/27,Benign,\N,intron_variant,1.212,0.4568,1KG_AMR_AF,OTOA
389157,16:21733138:G>A,NM_144672.3:c.1807-1088G>A,\N,\N,16/27,Benign,\N,intron_variant,0.067,0.0446,1KG_EAS_AF,OTOA
389158,16:21733168:G>C,NM_144672.3:c.1807-1058G>C,\N,\N,16/27,Unknown significance,\N,intron_variant,0.227,0.002,1KG_EUR_AF,OTOA
389159,16:21733212:C>T,NM_144672.3:c.1807-1014C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,1.472,\N,\N,OTOA
389160,16:21733266:C>T,NM_144672.3:c.1807-960C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,1.274,0.001,1KG_SAS_AF,OTOA
389161,16:21733267:G>A,NM_144672.3:c.1807-959G>A,\N,\N,16/27,Benign,\N,intron_variant,2.584,0.005,1KG_EAS_AF,OTOA
389162,16:21733282:C>G,NM_144672.3:c.1807-944C>G,\N,\N,16/27,Unknown significance,\N,intron_variant,0.146,0.001,1KG_EAS_AF,OTOA
389163,16:21733282:C>T,NM_144672.3:c.1807-944C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,0.366,\N,\N,OTOA
389164,16:21733311:G>A,NM_144672.3:c.1807-915G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,1.063,\N,\N,OTOA
389165,16:21733342:C>T,NM_144672.3:c.1807-884C>T,\N,\N,16/27,Benign,\N,intron_variant,2.575,0.2986,1KG_SAS_AF,OTOA
389166,16:21733345:A>C,NM_144672.3:c.1807-881A>C,\N,\N,16/27,Unknown significance,\N,intron_variant,4.692,0.001,1KG_SAS_AF,OTOA
389167,16:21733349:AGCCTG>A,NM_144672.3:c.1807-873_1807-869del,\N,\N,16/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389168,16:21733370:T>G,NM_144672.3:c.1807-856T>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.74,\N,\N,OTOA
389169,16:21733374:T>A,NM_144672.3:c.1807-852T>A,\N,\N,16/27,Unknown significance,\N,intron_variant,0.012,0.001,1KG_EAS_AF|1KG_EUR_AF,OTOA
389170,16:21733383:C>CA,NM_144672.3:c.1807-833dup,\N,\N,16/27,Unknown significance,\N,intron_variant,1.531,\N,\N,OTOA
389171,16:21733393:A>C,NM_144672.3:c.1807-833A>C,\N,\N,16/27,Unknown significance,\N,intron_variant,0.032,0.001,1KG_EUR_AF,OTOA
389172,16:21733394:C>A,NM_144672.3:c.1807-832C>A,\N,\N,16/27,Benign,\N,intron_variant,2.462,0.2575,1KG_EUR_AF,OTOA
389173,16:21733397:CA>C,NM_144672.3:c.1807-822del,\N,\N,16/27,Unknown significance,\N,intron_variant,3.203,\N,\N,OTOA
389174,16:21733398:A>C,NM_144672.3:c.1807-828A>C,\N,\N,16/27,Benign,\N,intron_variant,0.499,0.2575,1KG_EUR_AF,OTOA
389175,16:21733408:A>C,NM_144672.3:c.1807-818A>C,\N,\N,16/27,Unknown significance,\N,intron_variant,1.549,\N,\N,OTOA
389176,16:21733418:CA>C,NM_144672.3:c.1807-793del,\N,\N,16/27,Benign,\N,intron_variant,7.169,0.4813,1KG_AMR_AF,OTOA
389177,16:21733471:TA>T,NM_144672.3:c.1807-754del,\N,\N,16/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389178,16:21733475:C>T,NM_144672.3:c.1807-751C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,0.01,0.001,1KG_SAS_AF,OTOA
389179,16:21733476:G>T,NM_144672.3:c.1807-750G>T,\N,\N,16/27,Unknown significance,\N,intron_variant,0.073,\N,\N,OTOA
389180,16:21733486:C>T,NM_144672.3:c.1807-740C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,0.03,\N,\N,OTOA
389181,16:21733487:G>A,NM_144672.3:c.1807-739G>A,\N,\N,16/27,Benign,\N,intron_variant,1.426,0.0883,1KG_EAS_AF,OTOA
389182,16:21733514:C>T,NM_144672.3:c.1807-712C>T,\N,\N,16/27,Benign,\N,intron_variant,0.619,0.0287,1KG_AFR_AF,OTOA
389183,16:21733515:G>A,NM_144672.3:c.1807-711G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,0.024,0.002,1KG_SAS_AF,OTOA
389184,16:21733566:GA>G,NM_144672.3:c.1807-659del,\N,\N,16/27,Unknown significance,\N,intron_variant,4.91,\N,\N,OTOA
389185,16:21733566:GAGT>G,NM_144672.3:c.1807-659_1807-657del,\N,\N,16/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389186,16:21733591:C>CA,NM_144672.3:c.1807-623dup,\N,\N,16/27,Unknown significance,\N,intron_variant,2.228,\N,\N,OTOA
389187,16:21733594:A>AC,NM_144672.3:c.1807-632_1807-631insC,\N,\N,16/27,Benign,\N,intron_variant,0.005,0.2724,1KG_EUR_AF,OTOA
389188,16:21733594:A>C,NM_144672.3:c.1807-632A>C,\N,\N,16/27,Unknown significance,\N,intron_variant,0.018,0.002,1KG_SAS_AF,OTOA
389189,16:21733663:A>G,NM_144672.3:c.1807-563A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.44,\N,\N,OTOA
389190,16:21733664:T>G,NM_144672.3:c.1807-562T>G,\N,\N,16/27,Unknown significance,\N,intron_variant,0.489,\N,\N,OTOA
389191,16:21733670:A>T,NM_144672.3:c.1807-556A>T,\N,\N,16/27,Unknown significance,\N,intron_variant,0.113,\N,\N,OTOA
389192,16:21733677:A>G,NM_144672.3:c.1807-549A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.001,\N,\N,OTOA
389193,16:21733679:A>G,NM_144672.3:c.1807-547A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.252,\N,\N,OTOA
389194,16:21733688:AGCTAT>A,NM_144672.3:c.1807-537_1807-533del,\N,\N,16/27,Unknown significance,\N,intron_variant,3.979,\N,\N,OTOA
389195,16:21733689:G>A,NM_144672.3:c.1807-537G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,1.722,\N,\N,OTOA
389196,16:21733699:A>G,NM_144672.3:c.1807-527A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.327,\N,\N,OTOA
389197,16:21733700:CTA>C,NM_144672.3:c.1807-522_1807-521del,\N,\N,16/27,Benign,\N,intron_variant,2.273,0.3252,1KG_SAS_AF,OTOA
389198,16:21733704:A>G,NM_144672.3:c.1807-522A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,0.686,\N,\N,OTOA
389199,16:21733704:ATG>A,NM_144672.3:c.1807-520_1807-519del,\N,\N,16/27,Unknown significance,\N,intron_variant,0.812,\N,\N,OTOA
389200,16:21733705:T>C,NM_144672.3:c.1807-521T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,0.214,\N,\N,OTOA
389201,16:21733706:G>A,NM_144672.3:c.1807-520G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,0.33,\N,\N,OTOA
389202,16:21733711:G>A,NM_144672.3:c.1807-515G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,0.228,\N,\N,OTOA
389203,16:21733714:A>AAATAT,NM_144672.3:c.1807-511_1807-510insATATA,\N,\N,16/27,Unknown significance,\N,intron_variant,0.075,\N,\N,OTOA
389204,16:21733715:AG>A,NM_144672.3:c.1807-510del,\N,\N,16/27,Unknown significance,\N,intron_variant,0.158,\N,\N,OTOA
389205,16:21733721:A>AACTG,NM_144672.3:c.1807-505_1807-504insACTG,\N,\N,16/27,Unknown significance,\N,intron_variant,0.038,\N,\N,OTOA
389206,16:21733721:A>ATATAGTTAAATATAACTG,NM_144672.3:c.1807-501_1807-500insGTTAAATATAACTGTATA,\N,\N,16/27,Unknown significance,\N,intron_variant,0.013,\N,\N,OTOA
389207,16:21733731:ATG>A,NM_144672.3:c.1807-493_1807-492del,\N,\N,16/27,Unknown significance,\N,intron_variant,2.224,\N,\N,OTOA
389208,16:21733732:T>C,NM_144672.3:c.1807-494T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,0.647,0.001,1KG_EAS_AF,OTOA
389209,16:21733733:G>A,NM_144672.3:c.1807-493G>A,\N,\N,16/27,Benign,\N,intron_variant,1.116,0.2577,1KG_SAS_AF,OTOA
389210,16:21733746:A>G,NM_144672.3:c.1807-480A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,1.534,0.001,1KG_SAS_AF,OTOA
389211,16:21733776:A>T,NM_144672.3:c.1807-450A>T,\N,\N,16/27,Unknown significance,\N,intron_variant,0.414,0.001,1KG_EAS_AF,OTOA
389212,16:21733896:A>C,NM_144672.3:c.1807-330A>C,\N,\N,16/27,Unknown significance,\N,intron_variant,6.61,0.002,1KG_EAS_AF,OTOA
389213,16:21733920:T>G,NM_144672.3:c.1807-306T>G,\N,\N,16/27,Unknown significance,\N,intron_variant,7.177,0.0014,1KG_AMR_AF,OTOA
389214,16:21733924:T>C,NM_144672.3:c.1807-302T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,5.204,0.0008,1KG_AFR_AF,OTOA
389215,16:21734006:C>T,NM_144672.3:c.1807-220C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,1.319,0.0008,1KG_AFR_AF,OTOA
389216,16:21734009:T>C,NM_144672.3:c.1807-217T>C,\N,\N,16/27,Unknown significance,\N,intron_variant,2.77,0.001,1KG_EAS_AF,OTOA
389217,16:21734030:G>A,NM_144672.3:c.1807-196G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,2.909,\N,\N,OTOA
389218,16:21734034:G>A,NM_144672.3:c.1807-192G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,1.966,0.002,1KG_EUR_AF,OTOA
389219,16:21734059:C>G,NM_144672.3:c.1807-167C>G,\N,\N,16/27,Benign,\N,intron_variant,1.465,0.0109,1KG_EAS_AF,OTOA
389220,16:21734060:G>A,NM_144672.3:c.1807-166G>A,\N,\N,16/27,Benign,\N,intron_variant,0.388,0.0091,1KG_AFR_AF,OTOA
389221,16:21734089:G>A,NM_144672.3:c.1807-137G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,4.065,\N,\N,OTOA
389222,16:21734095:T>C,NM_144672.3:c.1807-131T>C,\N,\N,16/27,Benign,\N,intron_variant,1.889,0.0447,1KG_EUR_AF,OTOA
389223,16:21734124:G>T,NM_144672.3:c.1807-102G>T,\N,\N,16/27,Unknown significance,\N,intron_variant,1.156,0.002,1KG_EAS_AF,OTOA
389224,16:21734126:A>G,NM_144672.3:c.1807-100A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,2.058,0.001,1KG_SAS_AF,OTOA
389225,16:21734129:C>T,NM_144672.3:c.1807-97C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,1.605,0.001,1KG_EUR_AF,OTOA
389226,16:21734139:A>G,NM_144672.3:c.1807-87A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,5.14,0.001,1KG_EAS_AF,OTOA
389227,16:21734147:T>A,NM_144672.3:c.1807-79T>A,\N,\N,16/27,Unknown significance,\N,intron_variant,4.647,0.001,1KG_EAS_AF,OTOA
389228,16:21734167:G>A,NM_144672.3:c.1807-59G>A,\N,\N,16/27,Benign,\N,intron_variant,5.625,0.0194,1KG_SAS_AF,OTOA
389229,16:21734178:GTTC>G,NM_144672.3:c.1807-39_1807-37del,\N,\N,16/27,Unknown significance,\N,intron_variant,3.483,0.0000300824,EXAC_NFE_AF,OTOA
389230,16:21734197:T>A,NM_144672.3:c.1807-29T>A,\N,\N,16/27,Unknown significance,\N,intron_variant,4.964,0.000182304,EXAC_SAS_AF,OTOA
389231,16:21734198:A>T,NM_144672.3:c.1807-28A>T,\N,\N,16/27,Unknown significance,\N,intron_variant,1.218,0.0000607755,EXAC_SAS_AF,OTOA
389232,16:21734200:A>G,NM_144672.3:c.1807-26A>G,\N,\N,16/27,Unknown significance,\N,intron_variant,5.156,0.0000868508,EXAC_AMR_AF,OTOA
389233,16:21734203:C>T,NM_144672.3:c.1807-23C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,4.776,0.00022748,EVS_AA_AF,OTOA
389234,16:21734204:C>T,NM_144672.3:c.1807-22C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,6.697,0.000454959,EVS_AA_AF,OTOA
389235,16:21734205:C>T,NM_144672.3:c.1807-21C>T,\N,\N,16/27,Unknown significance,\N,intron_variant,4.865,0.000116279,EVS_EA_AF,OTOA
389236,16:21734210:C>G,NM_144672.3:c.1807-16C>G,\N,\N,16/27,Unknown significance,\N,intron_variant,13.94,0.0000300075,EXAC_NFE_AF,OTOA
389237,16:21734212:G>A,NM_144672.3:c.1807-14G>A,\N,\N,16/27,Unknown significance,\N,intron_variant,16.17,0.000115902,EXAC_EAS_AF,OTOA
389238,16:21734213:C>G,NM_144672.3:c.1807-13C>G,\N,\N,16/27,Unknown significance,\N,intron_variant,15.85,0.00022748,EVS_AA_AF,OTOA
389239,16:21734216:A>T,NM_144672.3:c.1807-10A>T,\N,\N,16/27,Unknown significance,\N,intron_variant,16.09,\N,\N,OTOA
389240,16:21734220:T>C,NM_144672.3:c.1807-6T>C,\N,\N,16/27,Unknown significance,\N,splice_region_variant&intron_variant,12.94,0.0000866101,EXAC_AMR_AF,OTOA
389241,16:21734226:G>A,NM_144672.3:c.1807G>A,NP_653273.3:p.Val603Ile,17/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,12.76,0.000181973,EXAC_SAS_AF,OTOA
389242,16:21734229:A>G,NM_144672.3:c.1810A>G,NP_653273.3:p.Asn604Asp,17/28,\N,Unknown significance,\N,missense_variant,23.8,0.0000865651,EXAC_AMR_AF,OTOA
389243,16:21734239:C>T,NM_144672.3:c.1820C>T,NP_653273.3:p.Ala607Val,17/28,\N,Unknown significance,\N,missense_variant,29.1,\N,\N,OTOA
389244,16:21734240:G>A,NM_144672.3:c.1821G>A,NP_653273.3:p.Ala607=,17/28,\N,Unknown significance,\N,synonymous_variant,14.65,0.00110132,EXAC_OTH_AF,OTOA
389245,16:21734255:A>G,NM_144672.3:c.1836A>G,NP_653273.3:p.Glu612=,17/28,\N,Unknown significance,\N,synonymous_variant,7.106,0.0000149876,EXAC_NFE_AF,OTOA
389246,16:21734264:A>T,NM_144672.3:c.1845A>T,NP_653273.3:p.Arg615Ser,17/28,\N,Likely benign,\N,missense_variant,12.92,0.0000149876,EXAC_NFE_AF,OTOA
389247,16:21734284:T>A,NM_144672.3:c.1865T>A,NP_653273.3:p.Leu622His,17/28,\N,Unknown significance,\N,missense_variant,29.1,0.000014988,EXAC_NFE_AF,OTOA
389248,16:21734298:C>T,NM_001161683.1:c.1642C>T,NP_001155155.1:p.Pro548Ser,13/24,\N,Pathogenic,Hearing loss| non-syndromic,missense_variant&splice_region_variant,31,0.000242365,EXAC_SAS_AF,OTOA
389249,16:21734299:C>G,NM_144672.3:c.1880C>G,NP_653273.3:p.Pro627Arg,17/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,31,\N,\N,OTOA
389250,16:21734299:C>T,NM_144672.3:c.1880C>T,NP_653273.3:p.Pro627Leu,17/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,34,0.00015124,EXAC_FIN_AF,OTOA
389251,16:21734300:G>A,NM_144672.3:c.1880+1G>A,\N,\N,17/27,Pathogenic,Deafness| autosomal recessive 22,splice_donor_variant,26,0.00022748,EVS_AA_AF,OTOA
389252,16:21734303:A>G,NM_144672.3:c.1880+4A>G,\N,\N,17/27,Unknown significance,\N,splice_region_variant&intron_variant,16.32,0.00022748,EVS_AA_AF,OTOA
389253,16:21734308:A>G,NM_144672.3:c.1880+9A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,17.76,0.001,1KG_SAS_AF,OTOA
389254,16:21734315:C>T,NM_144672.3:c.1880+16C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,16.16,0.000121271,EXAC_SAS_AF,OTOA
389255,16:21734316:C>T,NM_144672.3:c.1880+17C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,16.3,0.0000149966,EXAC_NFE_AF,OTOA
389256,16:21734318:C>T,NM_144672.3:c.1880+19C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,15.18,0.000192308,EXAC_AFR_AF,OTOA
389257,16:21734319:C>A,NM_144672.3:c.1880+20C>A,\N,\N,17/27,Unknown significance,\N,intron_variant,12.9,0.0015,1KG_AFR_AF,OTOA
389258,16:21734323:T>A,NM_144672.3:c.1880+24T>A,\N,\N,17/27,Unknown significance,\N,intron_variant,11.48,0.0000606943,EXAC_SAS_AF,OTOA
389259,16:21734332:A>C,NM_144672.3:c.1880+33A>C,\N,\N,17/27,Unknown significance,\N,intron_variant,4.192,0.0014,1KG_AMR_AF,OTOA
389260,16:21734344:G>A,NM_144672.3:c.1880+45G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,2.013,0.001,1KG_EAS_AF|1KG_EUR_AF,OTOA
389261,16:21734348:G>A,NM_144672.3:c.1880+49G>A,\N,\N,17/27,Benign,\N,intron_variant,4.034,0.0150426,EXAC_SAS_AF,OTOA
389262,16:21734417:A>G,NM_144672.3:c.1880+118A>G,\N,\N,17/27,Benign,\N,intron_variant,2.033,0.2753,1KG_EUR_AF,OTOA
389263,16:21734434:G>A,NM_144672.3:c.1880+135G>A,\N,\N,17/27,Benign,\N,intron_variant,7.247,0.0061,1KG_SAS_AF,OTOA
389264,16:21734449:G>T,NM_144672.3:c.1880+150G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,2.123,\N,\N,OTOA
389265,16:21734454:C>G,NM_144672.3:c.1880+155C>G,\N,\N,17/27,Unknown significance,\N,intron_variant,1.87,0.001,1KG_SAS_AF,OTOA
389266,16:21734557:C>T,NM_144672.3:c.1880+258C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,8.442,0.001,1KG_SAS_AF,OTOA
389267,16:21734559:G>C,NM_144672.3:c.1880+260G>C,\N,\N,17/27,Benign,\N,intron_variant,2.407,0.0102,1KG_SAS_AF,OTOA
389268,16:21734582:G>A,NM_144672.3:c.1880+283G>A,\N,\N,17/27,Benign,\N,intron_variant,2.312,0.0119,1KG_EUR_AF,OTOA
389269,16:21734591:A>AGG,NM_144672.3:c.1880+293_1880+294dup,\N,\N,17/27,Unknown significance,\N,intron_variant,3.71,\N,\N,OTOA
389270,16:21734628:C>T,NM_144672.3:c.1880+329C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,1.043,0.001,1KG_EAS_AF,OTOA
389271,16:21734631:T>C,NM_144672.3:c.1880+332T>C,\N,\N,17/27,Unknown significance,\N,intron_variant,2.476,0.001,1KG_EAS_AF,OTOA
389272,16:21734765:CA>C,NM_144672.3:c.1880+480del,\N,\N,17/27,Benign,\N,intron_variant,8.792,0.335,1KG_EUR_AF,OTOA
389273,16:21734798:G>A,NM_144672.3:c.1880+499G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,2.68,0.001,1KG_EUR_AF,OTOA
389274,16:21734800:G>C,NM_144672.3:c.1880+501G>C,\N,\N,17/27,Unknown significance,\N,intron_variant,0.146,0.002,1KG_EUR_AF,OTOA
389275,16:21734853:T>A,NM_144672.3:c.1880+554T>A,\N,\N,17/27,Unknown significance,\N,intron_variant,3.154,0.001,1KG_EUR_AF,OTOA
389276,16:21734913:T>C,NM_144672.3:c.1880+614T>C,\N,\N,17/27,Unknown significance,\N,intron_variant,4.879,\N,\N,OTOA
389277,16:21734932:G>T,NM_144672.3:c.1880+633G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,11.76,0.001,1KG_EUR_AF,OTOA
389278,16:21734938:A>G,NM_144672.3:c.1880+639A>G,\N,\N,17/27,Benign,\N,intron_variant,11.78,0.3119,1KG_SAS_AF,OTOA
389279,16:21734993:A>G,NM_144672.3:c.1880+694A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,1.68,\N,\N,OTOA
389280,16:21735019:C>T,NM_144672.3:c.1880+720C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,4.008,0.002,1KG_EUR_AF,OTOA
389281,16:21735054:G>A,NM_144672.3:c.1880+755G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,4.915,\N,\N,OTOA
389282,16:21735074:G>A,NM_144672.3:c.1880+775G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,3.481,0.003,1KG_AFR_AF,OTOA
389283,16:21735124:C>T,NM_144672.3:c.1880+825C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,3.045,\N,\N,OTOA
389284,16:21735208:A>G,NM_144672.3:c.1880+909A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,1.17,0.001,1KG_EAS_AF,OTOA
389285,16:21735242:C>T,NM_144672.3:c.1880+943C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,0.183,\N,\N,OTOA
389286,16:21735243:G>A,NM_144672.3:c.1880+944G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,0.147,\N,\N,OTOA
389287,16:21735294:G>A,NM_144672.3:c.1880+995G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,3.023,0.0014,1KG_AMR_AF,OTOA
389288,16:21735337:C>G,NM_144672.3:c.1880+1038C>G,\N,\N,17/27,Unknown significance,\N,intron_variant,0.857,\N,\N,OTOA
389289,16:21735337:C>T,NM_144672.3:c.1880+1038C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,0.968,\N,\N,OTOA
389290,16:21735401:A>G,NM_144672.3:c.1880+1102A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,7.833,0.0008,1KG_AFR_AF,OTOA
389291,16:21735409:T>C,NM_144672.3:c.1880+1110T>C,\N,\N,17/27,Unknown significance,\N,intron_variant,4.967,\N,\N,OTOA
389292,16:21735436:G>A,NM_144672.3:c.1880+1137G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,0.061,0.0031,1KG_SAS_AF,OTOA
389293,16:21735449:G>A,NM_144672.3:c.1880+1150G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,0.123,0.0008,1KG_AFR_AF,OTOA
389294,16:21735488:G>T,NM_144672.3:c.1880+1189G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,4.374,\N,\N,OTOA
389295,16:21735502:G>T,NM_144672.3:c.1880+1203G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,5.924,\N,\N,OTOA
389296,16:21735529:C>G,NM_144672.3:c.1880+1230C>G,\N,\N,17/27,Unknown significance,\N,intron_variant,0.841,\N,\N,OTOA
389297,16:21735579:G>C,NM_144672.3:c.1880+1280G>C,\N,\N,17/27,Benign,\N,intron_variant,0.508,0.4467,1KG_AMR_AF,OTOA
389298,16:21735633:G>A,NM_144672.3:c.1880+1334G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,2.349,0.002,1KG_EUR_AF,OTOA
389299,16:21735639:A>T,NM_144672.3:c.1880+1340A>T,\N,\N,17/27,Unknown significance,\N,intron_variant,0.951,\N,\N,OTOA
389300,16:21735689:G>A,NM_144672.3:c.1880+1390G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,2.213,0.001,1KG_EUR_AF,OTOA
389301,16:21735708:A>G,NM_144672.3:c.1880+1409A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,2.988,\N,\N,OTOA
389302,16:21735714:A>C,NM_144672.3:c.1880+1415A>C,\N,\N,17/27,Unknown significance,\N,intron_variant,0.397,0.0008,1KG_AFR_AF,OTOA
389303,16:21735719:A>G,NM_144672.3:c.1880+1420A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,3.806,0.002,1KG_EAS_AF|1KG_EUR_AF,OTOA
389304,16:21735741:G>T,NM_144672.3:c.1880+1442G>T,\N,\N,17/27,Benign,\N,intron_variant,1.376,0.2714,1KG_EUR_AF,OTOA
389305,16:21735774:CA>C,NM_144672.3:c.1880+1476del,\N,\N,17/27,Unknown significance,\N,intron_variant,5.346,\N,\N,OTOA
389306,16:21735776:GAGAGTTAAGGGACATCAGATCATGGGGGC>G,NM_144672.3:c.1880+1478_1880+1506del,\N,\N,17/27,Unknown significance,\N,intron_variant,3.688,\N,\N,OTOA
389307,16:21735828:A>G,NM_144672.3:c.1880+1529A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,4.332,\N,\N,OTOA
389308,16:21735872:A>G,NM_144672.3:c.1880+1573A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,3.355,\N,\N,OTOA
389309,16:21735946:C>T,NM_144672.3:c.1880+1647C>T,\N,\N,17/27,Benign,\N,intron_variant,16.97,0.0068,1KG_AFR_AF,OTOA
389310,16:21735950:A>G,NM_144672.3:c.1880+1651A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,16.87,\N,\N,OTOA
389311,16:21735974:C>T,NM_144672.3:c.1880+1675C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,4.874,\N,\N,OTOA
389312,16:21736000:A>T,NM_144672.3:c.1880+1701A>T,\N,\N,17/27,Benign,\N,intron_variant,1.571,0.3108,1KG_SAS_AF,OTOA
389313,16:21736024:C>T,NM_144672.3:c.1880+1725C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,1.244,\N,\N,OTOA
389314,16:21736050:C>T,NM_144672.3:c.1880+1751C>T,\N,\N,17/27,Benign,\N,intron_variant,1.004,0.0099,1KG_EAS_AF,OTOA
389315,16:21736060:G>T,NM_144672.3:c.1880+1761G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,1.164,\N,\N,OTOA
389316,16:21736069:T>G,NM_144672.3:c.1880+1770T>G,\N,\N,17/27,Unknown significance,\N,intron_variant,5.354,0.0008,1KG_AFR_AF,OTOA
389317,16:21736086:A>T,NM_144672.3:c.1881-1758A>T,\N,\N,17/27,Unknown significance,\N,intron_variant,1.504,\N,\N,OTOA
389318,16:21736087:T>A,NM_144672.3:c.1881-1757T>A,\N,\N,17/27,Unknown significance,\N,intron_variant,5.864,\N,\N,OTOA
389319,16:21736097:A>T,NM_144672.3:c.1881-1747A>T,\N,\N,17/27,Benign,\N,intron_variant,0.584,0.0249,1KG_EUR_AF,OTOA
389320,16:21736101:A>T,NM_144672.3:c.1881-1743A>T,\N,\N,17/27,Benign,\N,intron_variant,0.057,0.5845,1KG_EUR_AF,OTOA
389321,16:21736105:T>A,NM_144672.3:c.1881-1739T>A,\N,\N,17/27,Unknown significance,\N,intron_variant,0.994,0.002,1KG_EAS_AF,OTOA
389322,16:21736153:A>C,NM_144672.3:c.1881-1691A>C,\N,\N,17/27,Unknown significance,\N,intron_variant,0.797,\N,\N,OTOA
389323,16:21736158:T>G,NM_144672.3:c.1881-1686T>G,\N,\N,17/27,Unknown significance,\N,intron_variant,0.848,\N,\N,OTOA
389324,16:21736184:G>A,NM_144672.3:c.1881-1660G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,0.138,0.0014,1KG_AMR_AF,OTOA
389325,16:21736185:C>T,NM_144672.3:c.1881-1659C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,2.401,0.004,1KG_EAS_AF,OTOA
389326,16:21736187:A>T,NM_144672.3:c.1881-1657A>T,\N,\N,17/27,Unknown significance,\N,intron_variant,0.837,\N,\N,OTOA
389327,16:21736231:G>T,NM_144672.3:c.1881-1613G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,0.259,0.0014,1KG_AMR_AF,OTOA
389328,16:21736247:G>A,NM_144672.3:c.1881-1597G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,1.45,\N,\N,OTOA
389329,16:21736259:G>A,NM_144672.3:c.1881-1585G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,1.839,0.001,1KG_EAS_AF,OTOA
389330,16:21736270:G>A,NM_144672.3:c.1881-1574G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,0.471,\N,\N,OTOA
389331,16:21736298:C>G,NM_144672.3:c.1881-1546C>G,\N,\N,17/27,Unknown significance,\N,intron_variant,0.292,\N,\N,OTOA
389332,16:21736378:C>T,NM_144672.3:c.1881-1466C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,4.209,\N,\N,OTOA
389333,16:21736379:G>A,NM_144672.3:c.1881-1465G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,2.132,0.0008,1KG_AFR_AF,OTOA
389334,16:21736511:C>T,NM_144672.3:c.1881-1333C>T,\N,\N,17/27,Benign,\N,intron_variant,2.045,0.2714,1KG_EUR_AF,OTOA
389335,16:21736512:C>A,NM_144672.3:c.1881-1332C>A,\N,\N,17/27,Unknown significance,\N,intron_variant,0.936,0.0008,1KG_AFR_AF,OTOA
389336,16:21736516:C>T,NM_144672.3:c.1881-1328C>T,\N,\N,17/27,Benign,\N,intron_variant,1.781,0.005,1KG_EUR_AF,OTOA
389337,16:21736519:A>C,NM_144672.3:c.1881-1325A>C,\N,\N,17/27,Unknown significance,\N,intron_variant,1.022,\N,\N,OTOA
389338,16:21736520:C>G,NM_144672.3:c.1881-1324C>G,\N,\N,17/27,Unknown significance,\N,intron_variant,0.8,\N,\N,OTOA
389339,16:21736581:G>A,NM_144672.3:c.1881-1263G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,2.759,\N,\N,OTOA
389340,16:21736610:G>T,NM_144672.3:c.1881-1234G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,6.757,0.001,1KG_EAS_AF,OTOA
389341,16:21736628:C>T,NM_144672.3:c.1881-1216C>T,\N,\N,17/27,Benign,\N,intron_variant,9.261,0.0102,1KG_SAS_AF,OTOA
389342,16:21736655:G>T,NM_144672.3:c.1881-1189G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,11.52,0.0008,1KG_AFR_AF,OTOA
389343,16:21736667:G>A,NM_144672.3:c.1881-1177G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,13.24,\N,\N,OTOA
389344,16:21736669:G>C,NM_144672.3:c.1881-1175G>C,\N,\N,17/27,Unknown significance,\N,intron_variant,10.74,0.001,1KG_EUR_AF,OTOA
389345,16:21736701:G>A,NM_144672.3:c.1881-1143G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,8.045,0.001,1KG_SAS_AF,OTOA
389346,16:21736726:C>T,NM_144672.3:c.1881-1118C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,3.817,0.0014,1KG_AMR_AF,OTOA
389347,16:21736748:G>A,NM_144672.3:c.1881-1096G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,1.884,\N,\N,OTOA
389348,16:21736807:C>G,NM_144672.3:c.1881-1037C>G,\N,\N,17/27,Unknown significance,\N,intron_variant,1.365,0.001,1KG_EUR_AF,OTOA
389349,16:21736813:C>T,NM_144672.3:c.1881-1031C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,5.936,0.0008,1KG_AFR_AF,OTOA
389350,16:21736814:G>A,NM_144672.3:c.1881-1030G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,6.752,\N,\N,OTOA
389351,16:21736828:C>T,NM_144672.3:c.1881-1016C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,14.54,0.002,1KG_SAS_AF,OTOA
389352,16:21736837:GATCTCA>G,NM_144672.3:c.1881-1006_1881-1001del,\N,\N,17/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389353,16:21736952:G>T,NM_144672.3:c.1881-892G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,0.195,0.0023,1KG_AFR_AF,OTOA
389354,16:21736956:G>A,NM_144672.3:c.1881-888G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,1.74,0.001,1KG_EUR_AF,OTOA
389355,16:21736971:A>AT,NM_144672.3:c.1881-873_1881-872insT,\N,\N,17/27,Unknown significance,\N,intron_variant,0.29,\N,\N,OTOA
389356,16:21736994:C>T,NM_144672.3:c.1881-850C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,0.302,\N,\N,OTOA
389357,16:21736995:G>A,NM_144672.3:c.1881-849G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,4.777,\N,\N,OTOA
389358,16:21737013:G>A,NM_144672.3:c.1881-831G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,5.074,0.004,1KG_EAS_AF,OTOA
389359,16:21737048:G>A,NM_144672.3:c.1881-796G>A,\N,\N,17/27,Benign,\N,intron_variant,2.721,0.0159,1KG_EUR_AF,OTOA
389360,16:21737053:G>T,NM_144672.3:c.1881-791G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,1.315,0.001,1KG_SAS_AF,OTOA
389361,16:21737065:G>A,NM_144672.3:c.1881-779G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,0.588,0.001,1KG_EUR_AF,OTOA
389362,16:21737106:T>G,NM_144672.3:c.1881-738T>G,\N,\N,17/27,Unknown significance,\N,intron_variant,3.282,\N,\N,OTOA
389363,16:21737247:C>T,NM_144672.3:c.1881-597C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,1.906,0.0008,1KG_AFR_AF,OTOA
389364,16:21737256:G>C,NM_144672.3:c.1881-588G>C,\N,\N,17/27,Unknown significance,\N,intron_variant,0.645,\N,\N,OTOA
389365,16:21737300:A>G,NM_144672.3:c.1881-544A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,1.654,0.001,1KG_EAS_AF,OTOA
389366,16:21737325:G>A,NM_144672.3:c.1881-519G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,8.88,\N,\N,OTOA
389367,16:21737368:T>C,NM_144672.3:c.1881-476T>C,\N,\N,17/27,Benign,\N,intron_variant,0.446,0.0545,1KG_AFR_AF,OTOA
389368,16:21737398:C>T,NM_144672.3:c.1881-446C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,6.283,0.0014,1KG_AMR_AF,OTOA
389369,16:21737402:G>A,NM_144672.3:c.1881-442G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,7.205,\N,\N,OTOA
389370,16:21737414:T>C,NM_144672.3:c.1881-430T>C,\N,\N,17/27,Benign,\N,intron_variant,11.92,0.3119,1KG_SAS_AF,OTOA
389371,16:21737417:A>G,NM_144672.3:c.1881-427A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,14.58,0.001,1KG_SAS_AF,OTOA
389372,16:21737427:T>C,NM_144672.3:c.1881-417T>C,\N,\N,17/27,Unknown significance,\N,intron_variant,16.4,0.0015,1KG_AFR_AF,OTOA
389373,16:21737467:A>G,NM_144672.3:c.1881-377A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,3.611,\N,\N,OTOA
389374,16:21737469:A>G,NM_144672.3:c.1881-375A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,0.585,\N,\N,OTOA
389375,16:21737480:C>T,NM_144672.3:c.1881-364C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,0.119,\N,\N,OTOA
389376,16:21737500:A>C,NM_144672.3:c.1881-344A>C,\N,\N,17/27,Unknown significance,\N,intron_variant,8.229,\N,\N,OTOA
389377,16:21737505:T>G,NM_144672.3:c.1881-339T>G,\N,\N,17/27,Benign,\N,intron_variant,10.77,0.0098,1KG_AFR_AF,OTOA
389378,16:21737508:G>C,NM_144672.3:c.1881-336G>C,\N,\N,17/27,Benign,\N,intron_variant,6.784,0.3108,1KG_SAS_AF,OTOA
389379,16:21737519:G>A,NM_144672.3:c.1881-325G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,3.844,\N,\N,OTOA
389380,16:21737551:C>G,NM_144672.3:c.1881-293C>G,\N,\N,17/27,Unknown significance,\N,intron_variant,0.534,\N,\N,OTOA
389381,16:21737560:G>A,NM_144672.3:c.1881-284G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,0.336,0.001,1KG_EUR_AF,OTOA
389382,16:21737562:C>A,NM_144672.3:c.1881-282C>A,\N,\N,17/27,Unknown significance,\N,intron_variant,3.522,0.001,1KG_EAS_AF,OTOA
389383,16:21737611:T>C,NM_144672.3:c.1881-233T>C,\N,\N,17/27,Unknown significance,\N,intron_variant,3.076,0.0008,1KG_AFR_AF,OTOA
389384,16:21737626:G>A,NM_144672.3:c.1881-218G>A,\N,\N,17/27,Benign,\N,intron_variant,2.367,0.4831,1KG_EAS_AF,OTOA
389385,16:21737670:G>A,NM_144672.3:c.1881-174G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,14.87,0.001,1KG_SAS_AF,OTOA
389386,16:21737674:A>T,NM_144672.3:c.1881-170A>T,\N,\N,17/27,Unknown significance,\N,intron_variant,15.44,0.003,1KG_EUR_AF,OTOA
389387,16:21737706:G>A,NM_144672.3:c.1881-138G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,11.66,\N,\N,OTOA
389388,16:21737728:G>A,NM_144672.3:c.1881-116G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,7.171,0.001,1KG_EUR_AF,OTOA
389389,16:21737774:G>A,NM_144672.3:c.1881-70G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,2.282,0.004,1KG_EAS_AF,OTOA
389390,16:21737775:G>A,NM_144672.3:c.1881-69G>A,\N,\N,17/27,Benign,\N,intron_variant,2.892,0.0437,1KG_EUR_AF,OTOA
389391,16:21737783:T>C,NM_144672.3:c.1881-61T>C,\N,\N,17/27,Unknown significance,\N,intron_variant,4.564,0.001,1KG_SAS_AF,OTOA
389392,16:21737796:C>G,NM_144672.3:c.1881-48C>G,\N,\N,17/27,Unknown significance,\N,intron_variant,3.029,\N,\N,OTOA
389393,16:21737801:G>C,NM_144672.3:c.1881-43G>C,\N,\N,17/27,Unknown significance,\N,intron_variant,1.077,0.0000149867,EXAC_NFE_AF,OTOA
389394,16:21737804:G>A,NM_144672.3:c.1881-40G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,6.091,0.0000149871,EXAC_NFE_AF,OTOA
389395,16:21737805:C>T,NM_144672.3:c.1881-39C>T,\N,\N,17/27,Unknown significance,\N,intron_variant,5.938,0.000172771,EXAC_AMR_AF,OTOA
389396,16:21737811:G>A,NM_144672.3:c.1881-33G>A,\N,\N,17/27,Unknown significance,\N,intron_variant,2.625,0.00110375,EXAC_OTH_AF,OTOA
389397,16:21737811:G>T,NM_144672.3:c.1881-33G>T,\N,\N,17/27,Unknown significance,\N,intron_variant,0.902,0.000116279,EVS_EA_AF,OTOA
389398,16:21737829:C>G,NM_144672.3:c.1881-15C>G,\N,\N,17/27,Unknown significance,\N,intron_variant,2.62,0.0000149858,EXAC_NFE_AF,OTOA
389399,16:21737830:C>G,NM_144672.3:c.1881-14C>G,\N,\N,17/27,Unknown significance,\N,intron_variant,0.848,\N,\N,OTOA
389400,16:21737832:A>G,NM_144672.3:c.1881-12A>G,\N,\N,17/27,Unknown significance,\N,intron_variant,2.189,0.000289743,EXAC_AFR_AF,OTOA
389401,16:21737845:G>A,NM_144672.3:c.1882G>A,NP_653273.3:p.Ala628Thr,18/28,\N,Likely benign,\N,missense_variant&splice_region_variant,12.7,0.0000963206,EXAC_AFR_AF,OTOA
389402,16:21737846:C>A,NM_170664.2:c.911C>A,NP_733764.1:p.Ala304Asp,9/19,\N,Unknown significance,\N,missense_variant&splice_region_variant,24.2,0.000014984,EXAC_NFE_AF,OTOA
389403,16:21737846:C>G,NM_144672.3:c.1883C>G,NP_653273.3:p.Ala628Gly,18/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,19.61,0.000014984,EXAC_NFE_AF,OTOA
389404,16:21737848:C>T,NM_144672.3:c.1885C>T,NP_653273.3:p.Arg629Cys,18/28,\N,Unknown significance,\N,missense_variant,31,0.000454959,EVS_AA_AF,OTOA
389405,16:21737849:G>A,NM_144672.3:c.1886G>A,NP_653273.3:p.Arg629His,18/28,\N,Likely benign,\N,missense_variant,8.03,0.000121139,EXAC_SAS_AF,OTOA
389406,16:21737852:A>G,NM_144672.3:c.1889A>G,NP_653273.3:p.Tyr630Cys,18/28,\N,Unknown significance,\N,missense_variant,22.5,0.000014984,EXAC_NFE_AF,OTOA
389407,16:21737866:C>T,NM_144672.3:c.1903C>T,NP_653273.3:p.Pro635Ser,18/28,\N,Likely benign,\N,missense_variant,12.59,0.0000149835,EXAC_NFE_AF,OTOA
389408,16:21737867:C>A,NM_144672.3:c.1904C>A,NP_653273.3:p.Pro635Gln,18/28,\N,Unknown significance,\N,missense_variant,23.7,0.000029967,EXAC_NFE_AF,OTOA
389409,16:21737870:C>G,NM_144672.3:c.1907C>G,NP_653273.3:p.Ala636Gly,18/28,\N,Likely benign,\N,missense_variant,14.1,0.0000599341,EXAC_NFE_AF,OTOA
389410,16:21737872:T>C,NM_144672.3:c.1909T>C,NP_653273.3:p.Ser637Pro,18/28,\N,Unknown significance,\N,missense_variant,19.4,0.00110132,EXAC_OTH_AF,OTOA
389411,16:21737879:G>T,NM_144672.3:c.1916G>T,NP_653273.3:p.Cys639Phe,18/28,\N,Unknown significance,\N,missense_variant,29.2,0.0000149835,EXAC_NFE_AF,OTOA
389412,16:21737880:T>C,NM_144672.3:c.1917T>C,NP_653273.3:p.Cys639=,18/28,\N,Unknown significance,\N,synonymous_variant,1.007,0.000060562,EXAC_SAS_AF,OTOA
389413,16:21737884:C>A,NM_144672.3:c.1921C>A,NP_653273.3:p.Pro641Thr,18/28,\N,Unknown significance,\N,missense_variant,23.5,0.00022748,EVS_AA_AF,OTOA
389414,16:21737890:C>G,NM_144672.3:c.1927C>G,NP_653273.3:p.Leu643Val,18/28,\N,Likely benign,\N,missense_variant,17.09,0.000116279,EVS_EA_AF,OTOA
389415,16:21737901:G>C,NM_144672.3:c.1938G>C,NP_653273.3:p.Leu646=,18/28,\N,Unknown significance,\N,synonymous_variant,7.993,0.000115554,EXAC_EAS_AF,OTOA
389416,16:21737902:G>C,NM_144672.3:c.1939G>C,NP_653273.3:p.Gly647Arg,18/28,\N,Pathogenic,Hearing loss| non-syndromic| autosomal recessive,missense_variant,23.6,\N,\N,OTOA
389417,16:21737909:G>A,NM_144672.3:c.1946G>A,NP_653273.3:p.Ser649Asn,18/28,\N,Likely benign,\N,missense_variant,0.867,0.001,1KG_EAS_AF,OTOA
389418,16:21737914:T>A,NM_144672.3:c.1951T>A,NP_653273.3:p.Leu651Met,18/28,\N,Likely benign,\N,missense_variant,10.7,0.000029967,EXAC_NFE_AF,OTOA
389419,16:21737938:C>T,NM_144672.3:c.1975C>T,NP_653273.3:p.His659Tyr,18/28,\N,Likely benign,\N,missense_variant,8.422,0.000060562,EXAC_SAS_AF,OTOA
389420,16:21737948:CT>C,NM_144672.3:c.1987del,NP_653273.3:p.Ser663GlnfsTer65,18/28,\N,Unknown significance,\N,frameshift_variant,25,0.0000149835,EXAC_NFE_AF,OTOA
389421,16:21737955:C>T,NM_144672.3:c.1992C>T,NP_653273.3:p.Val664=,18/28,\N,Unknown significance,\N,synonymous_variant,15.81,0.000115554,EXAC_EAS_AF,OTOA
389422,16:21737956:C>T,NM_170664.2:c.1021C>T,NP_733764.1:p.Leu341Phe,9/19,\N,Unknown significance,\N,missense_variant,25.7,0.000115554,EXAC_EAS_AF,OTOA
389423,16:21737957:T>C,NM_144672.3:c.1994T>C,NP_653273.3:p.Leu665Pro,18/28,\N,Unknown significance,\N,missense_variant,26.9,0.000014984,EXAC_NFE_AF,OTOA
389424,16:21737961:G>A,NM_144672.3:c.1998G>A,NP_653273.3:p.Arg666=,18/28,\N,Unknown significance,\N,synonymous_variant,9.931,0.000259157,EXAC_AMR_AF,OTOA
389425,16:21737977:C>T,NM_144672.3:c.2014C>T,NP_653273.3:p.Leu672=,18/28,\N,Unknown significance,\N,splice_region_variant&synonymous_variant,14.18,0.0000149853,EXAC_NFE_AF,OTOA
389426,16:21737979:G>A,NM_144672.3:c.2016G>A,NP_653273.3:p.Leu672=,18/28,\N,Unknown significance,\N,splice_region_variant&synonymous_variant,14.88,0.0000961354,EXAC_AFR_AF,OTOA
389427,16:21737991:C>A,NM_144672.3:c.2016+12C>A,\N,\N,18/27,Unknown significance,\N,intron_variant,6.21,0.0000149885,EXAC_NFE_AF,OTOA
389428,16:21737994:C>T,NM_144672.3:c.2016+15C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,3.843,0.0000149889,EXAC_NFE_AF,OTOA
389429,16:21738006:C>T,NM_144672.3:c.2016+27C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,2.807,0.000454959,EVS_AA_AF,OTOA
389430,16:21738008:C>T,NM_144672.3:c.2016+29C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,3.837,0.000462535,EXAC_EAS_AF,OTOA
389431,16:21738014:G>A,NM_144672.3:c.2016+35G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,3.581,0.0000450194,EXAC_NFE_AF,OTOA
389432,16:21738022:G>A,NM_144672.3:c.2016+43G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,3.728,0.0000605767,EXAC_SAS_AF,OTOA
389433,16:21738121:G>T,NM_144672.3:c.2016+142G>T,\N,\N,18/27,Unknown significance,\N,intron_variant,2.036,\N,\N,OTOA
389434,16:21738133:A>G,NM_144672.3:c.2016+154A>G,\N,\N,18/27,Unknown significance,\N,intron_variant,7.199,0.0008,1KG_AFR_AF,OTOA
389435,16:21738147:T>C,NM_144672.3:c.2016+168T>C,\N,\N,18/27,Unknown significance,\N,intron_variant,3.38,\N,\N,OTOA
389436,16:21738186:G>T,NM_144672.3:c.2016+207G>T,\N,\N,18/27,Unknown significance,\N,intron_variant,1.3,\N,\N,OTOA
389437,16:21738205:G>A,NM_144672.3:c.2016+226G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,5.235,0.003,1KG_EAS_AF,OTOA
389438,16:21738209:A>G,NM_144672.3:c.2016+230A>G,\N,\N,18/27,Benign,\N,intron_variant,2.334,0.0204,1KG_SAS_AF,OTOA
389439,16:21738235:C>T,NM_144672.3:c.2016+256C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,4.247,0.001,1KG_SAS_AF,OTOA
389440,16:21738249:T>C,NM_144672.3:c.2016+270T>C,\N,\N,18/27,Unknown significance,\N,intron_variant,7.667,\N,\N,OTOA
389441,16:21738274:C>A,NM_144672.3:c.2016+295C>A,\N,\N,18/27,Unknown significance,\N,intron_variant,10.23,0.003,1KG_EUR_AF,OTOA
389442,16:21738290:C>T,NM_144672.3:c.2016+311C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,14.27,\N,\N,OTOA
389443,16:21738293:C>T,NM_144672.3:c.2016+314C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,16.69,\N,\N,OTOA
389444,16:21738305:G>A,NM_144672.3:c.2016+326G>A,\N,\N,18/27,Benign,\N,intron_variant,12.27,0.3088,1KG_SAS_AF,OTOA
389445,16:21738307:G>A,NM_144672.3:c.2016+328G>A,\N,\N,18/27,Benign,\N,intron_variant,8.569,0.0076,1KG_AFR_AF,OTOA
389446,16:21738309:G>A,NM_144672.3:c.2016+330G>A,\N,\N,18/27,Benign,\N,intron_variant,2.985,0.3088,1KG_SAS_AF,OTOA
389447,16:21738313:A>G,NM_144672.3:c.2016+334A>G,\N,\N,18/27,Unknown significance,\N,intron_variant,2.609,\N,\N,OTOA
389448,16:21738320:C>T,NM_144672.3:c.2016+341C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,2.985,\N,\N,OTOA
389449,16:21738333:G>GT,NM_144672.3:c.2016+376dup,\N,\N,18/27,Unknown significance,\N,intron_variant,0.685,\N,\N,OTOA
389450,16:21738357:G>T,NM_144672.3:c.2016+378G>T,\N,\N,18/27,Unknown significance,\N,intron_variant,0.183,\N,\N,OTOA
389451,16:21738358:G>T,NM_144672.3:c.2016+379G>T,\N,\N,18/27,Unknown significance,\N,intron_variant,0.43,\N,\N,OTOA
389452,16:21738400:C>T,NM_144672.3:c.2016+421C>T,\N,\N,18/27,Benign,\N,intron_variant,0.14,0.0083,1KG_AFR_AF,OTOA
389453,16:21738401:G>A,NM_144672.3:c.2016+422G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,0.745,0.001,1KG_EAS_AF,OTOA
389454,16:21738428:C>T,NM_144672.3:c.2016+449C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,2.34,0.0014,1KG_AMR_AF,OTOA
389455,16:21738468:G>T,NM_144672.3:c.2016+489G>T,\N,\N,18/27,Unknown significance,\N,intron_variant,0.729,0.001,1KG_EUR_AF,OTOA
389456,16:21738469:C>T,NM_144672.3:c.2016+490C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,1.548,\N,\N,OTOA
389457,16:21738484:T>C,NM_144672.3:c.2016+505T>C,\N,\N,18/27,Benign,\N,intron_variant,0.146,0.4871,1KG_EAS_AF,OTOA
389458,16:21738485:G>A,NM_144672.3:c.2016+506G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,1.132,0.001,1KG_EUR_AF,OTOA
389459,16:21738493:A>G,NM_144672.3:c.2016+514A>G,\N,\N,18/27,Unknown significance,\N,intron_variant,2.073,\N,\N,OTOA
389460,16:21738499:G>A,NM_144672.3:c.2016+520G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,0.973,0.001,1KG_EUR_AF,OTOA
389461,16:21738510:G>T,NM_144672.3:c.2016+531G>T,\N,\N,18/27,Unknown significance,\N,intron_variant,0.379,0.004,1KG_EAS_AF,OTOA
389462,16:21738530:G>T,NM_144672.3:c.2016+551G>T,\N,\N,18/27,Benign,\N,intron_variant,0.462,0.0068,1KG_AFR_AF,OTOA
389463,16:21738534:C>A,NM_144672.3:c.2016+555C>A,\N,\N,18/27,Unknown significance,\N,intron_variant,2.305,\N,\N,OTOA
389464,16:21738589:C>T,NM_144672.3:c.2016+610C>T,\N,\N,18/27,Benign,\N,intron_variant,0.635,0.0106,1KG_AFR_AF,OTOA
389465,16:21738590:G>A,NM_144672.3:c.2016+611G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,1.614,0.001,1KG_EAS_AF|1KG_SAS_AF,OTOA
389466,16:21738595:C>T,NM_144672.3:c.2016+616C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,3.703,\N,\N,OTOA
389467,16:21738614:A>T,NM_144672.3:c.2016+635A>T,\N,\N,18/27,Unknown significance,\N,intron_variant,0.466,0.0014,1KG_AMR_AF,OTOA
389468,16:21738615:G>C,NM_144672.3:c.2016+636G>C,\N,\N,18/27,Unknown significance,\N,intron_variant,0.28,\N,\N,OTOA
389469,16:21738617:C>T,NM_144672.3:c.2016+638C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,0.092,\N,\N,OTOA
389470,16:21738620:G>A,NM_144672.3:c.2016+641G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,1.315,\N,\N,OTOA
389471,16:21738855:A>G,NM_144672.3:c.2017-707A>G,\N,\N,18/27,Unknown significance,\N,intron_variant,11.2,0.001,1KG_EAS_AF,OTOA
389472,16:21738859:A>G,NM_144672.3:c.2017-703A>G,\N,\N,18/27,Unknown significance,\N,intron_variant,11.8,0.002,1KG_EUR_AF|1KG_SAS_AF,OTOA
389473,16:21738896:T>A,NM_144672.3:c.2017-666T>A,\N,\N,18/27,Unknown significance,\N,intron_variant,3.967,\N,\N,OTOA
389474,16:21738928:T>C,NM_144672.3:c.2017-634T>C,\N,\N,18/27,Unknown significance,\N,intron_variant,0.224,0.001,1KG_EUR_AF,OTOA
389475,16:21738943:G>C,NM_144672.3:c.2017-619G>C,\N,\N,18/27,Unknown significance,\N,intron_variant,1.484,0.002,1KG_SAS_AF,OTOA
389476,16:21738970:G>A,NM_144672.3:c.2017-592G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,0.379,0.001,1KG_SAS_AF,OTOA
389477,16:21738987:G>C,NM_144672.3:c.2017-575G>C,\N,\N,18/27,Benign,\N,intron_variant,0.642,0.8971,1KG_AFR_AF,OTOA
389478,16:21738992:G>A,NM_144672.3:c.2017-570G>A,\N,\N,18/27,Benign,\N,intron_variant,2.747,0.1524,1KG_SAS_AF,OTOA
389479,16:21739013:A>G,NM_144672.3:c.2017-549A>G,\N,\N,18/27,Benign,\N,intron_variant,1.336,0.0238,1KG_EAS_AF,OTOA
389480,16:21739021:C>T,NM_144672.3:c.2017-541C>T,\N,\N,18/27,Benign,\N,intron_variant,2.334,0.4467,1KG_AMR_AF,OTOA
389481,16:21739041:C>T,NM_144672.3:c.2017-521C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,3.623,\N,\N,OTOA
389482,16:21739140:G>A,NM_144672.3:c.2017-422G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,1.99,\N,\N,OTOA
389483,16:21739177:C>A,NM_144672.3:c.2017-385C>A,\N,\N,18/27,Unknown significance,\N,intron_variant,6.071,0.001,1KG_EAS_AF,OTOA
389484,16:21739178:G>A,NM_144672.3:c.2017-384G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,7.752,\N,\N,OTOA
389485,16:21739187:T>C,NM_144672.3:c.2017-375T>C,\N,\N,18/27,Benign,\N,intron_variant,5.465,0.0051,1KG_SAS_AF,OTOA
389486,16:21739199:T>G,NM_144672.3:c.2017-363T>G,\N,\N,18/27,Unknown significance,\N,intron_variant,2.613,\N,\N,OTOA
389487,16:21739201:G>T,NM_144672.3:c.2017-361G>T,\N,\N,18/27,Unknown significance,\N,intron_variant,5.441,\N,\N,OTOA
389488,16:21739205:C>T,NM_144672.3:c.2017-357C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,9.312,\N,\N,OTOA
389489,16:21739215:C>T,NM_144672.3:c.2017-347C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,8.88,0.002,1KG_SAS_AF,OTOA
389490,16:21739239:A>G,NM_144672.3:c.2017-323A>G,\N,\N,18/27,Benign,\N,intron_variant,6.719,0.0102,1KG_SAS_AF,OTOA
389491,16:21739243:C>T,NM_144672.3:c.2017-319C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,4.966,\N,\N,OTOA
389492,16:21739264:C>A,NM_144672.3:c.2017-298C>A,\N,\N,18/27,Unknown significance,\N,intron_variant,0.711,0.0031,1KG_SAS_AF,OTOA
389493,16:21739268:C>T,NM_144672.3:c.2017-294C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,1.512,\N,\N,OTOA
389494,16:21739311:G>A,NM_144672.3:c.2017-251G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,0.385,0.001,1KG_EAS_AF|1KG_SAS_AF,OTOA
389495,16:21739332:T>C,NM_144672.3:c.2017-230T>C,\N,\N,18/27,Unknown significance,\N,intron_variant,0.497,\N,\N,OTOA
389496,16:21739373:A>G,NM_144672.3:c.2017-189A>G,\N,\N,18/27,Benign,\N,intron_variant,0.75,0.2714,1KG_EUR_AF,OTOA
389497,16:21739430:T>C,NM_144672.3:c.2017-132T>C,\N,\N,18/27,Benign,\N,intron_variant,2.014,0.4467,1KG_AMR_AF,OTOA
389498,16:21739437:C>T,NM_144672.3:c.2017-125C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,0.737,0.001,1KG_EAS_AF,OTOA
389499,16:21739440:C>T,NM_144672.3:c.2017-122C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,3.631,\N,\N,OTOA
389500,16:21739466:A>G,NM_144672.3:c.2017-96A>G,\N,\N,18/27,Unknown significance,\N,intron_variant,0.688,0.0008,1KG_AFR_AF,OTOA
389501,16:21739509:C>T,NM_144672.3:c.2017-53C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,6.5,\N,\N,OTOA
389502,16:21739511:C>T,NM_144672.3:c.2017-51C>T,\N,\N,18/27,Unknown significance,\N,intron_variant,1.158,0.00022748,EVS_AA_AF,OTOA
389503,16:21739512:G>A,NM_144672.3:c.2017-50G>A,\N,\N,18/27,Unknown significance,\N,intron_variant,5.551,0.000116279,EVS_EA_AF,OTOA
389504,16:21739514:TC>T,NM_144672.3:c.2017-47del,\N,\N,18/27,Unknown significance,\N,intron_variant,5.083,0.0000449883,EXAC_NFE_AF,OTOA
389505,16:21739562:G>A,NM_144672.3:c.2017G>A,NP_653273.3:p.Asp673Asn,19/28,\N,Likely benign,\N,missense_variant&splice_region_variant,0.951,0.0000149853,EXAC_NFE_AF,OTOA
389506,16:21739564:C>T,NM_144672.3:c.2019C>T,NP_653273.3:p.Asp673=,19/28,\N,Likely benign,\N,splice_region_variant&synonymous_variant,0.096,0.00105708,EXAC_AFR_AF,OTOA
389507,16:21739565:G>A,NM_144672.3:c.2020G>A,NP_653273.3:p.Asp674Asn,19/28,\N,Likely benign,\N,missense_variant,0.001,0.00105708,EXAC_AFR_AF,OTOA
389508,16:21739579:TG>T,NM_144672.3:c.2035del,NP_653273.3:p.Glu679SerfsTer49,19/28,\N,Unknown significance,\N,frameshift_variant,25.8,\N,\N,OTOA
389509,16:21739582:G>C,NM_144672.3:c.2037G>C,NP_653273.3:p.Glu679Asp,19/28,\N,Likely benign,\N,missense_variant,0.175,0.000060562,EXAC_SAS_AF,OTOA
389510,16:21739585:C>T,NM_144672.3:c.2040C>T,NP_653273.3:p.Tyr680=,19/28,\N,Unknown significance,\N,synonymous_variant,1.246,0.000116279,EVS_EA_AF,OTOA
389511,16:21739586:A>T,NM_144672.3:c.2041A>T,NP_653273.3:p.Thr681Ser,19/28,\N,Likely benign,\N,missense_variant,0.001,0.000151194,EXAC_FIN_AF,OTOA
389512,16:21739587:C>G,NM_144672.3:c.2042C>G,NP_653273.3:p.Thr681Ser,19/28,\N,Likely benign,\N,missense_variant,0.006,0.0000149849,EXAC_NFE_AF,OTOA
389513,16:21739587:C>T,NM_144672.3:c.2042C>T,NP_653273.3:p.Thr681Ile,19/28,\N,Likely benign,\N,missense_variant,6.193,0.000116279,EVS_EA_AF,OTOA
389514,16:21739595:A>G,NM_144672.3:c.2050A>G,NP_653273.3:p.Ile684Val,19/28,\N,Likely benign,\N,missense_variant,0.231,0.0000864304,EXAC_AMR_AF,OTOA
389515,16:21739600:G>A,NM_144672.3:c.2055G>A,NP_653273.3:p.Met685Ile,19/28,\N,Likely benign,\N,missense_variant,3.663,0.0000149853,EXAC_NFE_AF,OTOA
389516,16:21739605:A>G,NM_144672.3:c.2060A>G,NP_653273.3:p.Asn687Ser,19/28,\N,Likely benign,\N,missense_variant,0.005,0.0000299697,EXAC_NFE_AF,OTOA
389517,16:21739608:T>G,NM_144672.3:c.2063T>G,NP_653273.3:p.Leu688Arg,19/28,\N,Unknown significance,\N,missense_variant,24.8,0.0000149853,EXAC_NFE_AF,OTOA
389518,16:21739611:T>G,NM_144672.3:c.2066T>G,NP_653273.3:p.Leu689Arg,19/28,\N,Unknown significance,\N,missense_variant,26,0.000172801,EXAC_AMR_AF,OTOA
389519,16:21739612:G>A,NM_144672.3:c.2067G>A,NP_653273.3:p.Leu689=,19/28,\N,Unknown significance,\N,synonymous_variant,5.1,0.0000299706,EXAC_NFE_AF,OTOA
389520,16:21739616:C>T,NM_144672.3:c.2071C>T,NP_653273.3:p.His691Tyr,19/28,\N,Unknown significance,\N,missense_variant,25.4,0.0000149867,EXAC_NFE_AF,OTOA
389521,16:21739623:C>T,NM_144672.3:c.2078C>T,NP_653273.3:p.Pro693Leu,19/28,\N,Unknown significance,\N,missense_variant,27.7,0.0000299742,EXAC_NFE_AF,OTOA
389522,16:21739633:C>G,NM_144672.3:c.2088C>G,NP_653273.3:p.Ile696Met,19/28,\N,Likely benign,\N,missense_variant,0.009,0.0008,1KG_AFR_AF,OTOA
389523,16:21739634:A>G,NM_144672.3:c.2089A>G,NP_653273.3:p.Ile697Val,19/28,\N,Unknown significance,\N,missense_variant,10.87,\N,\N,OTOA
389524,16:21739635:T>C,NM_144672.3:c.2090T>C,NP_653273.3:p.Ile697Thr,19/28,\N,Unknown significance,\N,missense_variant,17.51,0.0000149876,EXAC_NFE_AF,OTOA
389525,16:21739636:C>T,NM_144672.3:c.2091C>T,NP_653273.3:p.Ile697=,19/28,\N,Unknown significance,\N,synonymous_variant,11.44,0.000172801,EXAC_AMR_AF,OTOA
389526,16:21739643:G>A,NM_144672.3:c.2098G>A,NP_653273.3:p.Gly700Arg,19/28,\N,Likely benign,\N,missense_variant,3.34,0.000014988,EXAC_NFE_AF,OTOA
389527,16:21739645:G>C,NM_144672.3:c.2100G>C,NP_653273.3:p.Gly700=,19/28,\N,Unknown significance,\N,synonymous_variant,0.274,0.000121124,EXAC_SAS_AF,OTOA
389528,16:21739648:C>T,NM_144672.3:c.2103C>T,NP_653273.3:p.Ile701=,19/28,\N,Unknown significance,\N,synonymous_variant,9.003,\N,\N,OTOA
389529,16:21739649:T>C,NM_001161683.1:c.1867T>C,NP_001155155.1:p.Ser623Pro,15/24,\N,Unknown significance,\N,missense_variant,23.2,0.000060562,EXAC_SAS_AF,OTOA
389530,16:21739656:G>A,NM_144672.3:c.2111G>A,NP_653273.3:p.Arg704Lys,19/28,\N,Likely benign,\N,missense_variant,0.432,0.000115554,EXAC_EAS_AF,OTOA
389531,16:21739659:C>T,NM_144672.3:c.2114C>T,NP_653273.3:p.Ala705Val,19/28,\N,Unknown significance,\N,missense_variant,23.6,0.0000864155,EXAC_AMR_AF,OTOA
389532,16:21739664:G>A,NM_144672.3:c.2119G>A,NP_653273.3:p.Ala707Thr,19/28,\N,Unknown significance,\N,missense_variant,13.45,0.0000864304,EXAC_AMR_AF,OTOA
389533,16:21739665:C>T,NM_144672.3:c.2120C>T,NP_653273.3:p.Ala707Val,19/28,\N,Benign,\N,missense_variant,19.35,0.0112,1KG_SAS_AF,OTOA
389534,16:21739666:G>A,NM_144672.3:c.2121G>A,NP_653273.3:p.Ala707=,19/28,\N,Unknown significance,\N,synonymous_variant,7.39,0.000116279,EVS_EA_AF,OTOA
389535,16:21739666:G>C,NM_144672.3:c.2121G>C,NP_653273.3:p.Ala707=,19/28,\N,Unknown significance,\N,synonymous_variant,4.129,0.000259336,EXAC_AMR_AF,OTOA
389536,16:21739676:C>T,NM_001161683.1:c.1894C>T,NP_001155155.1:p.His632Tyr,15/24,\N,Likely benign,\N,missense_variant,1.112,0.0000149979,EXAC_NFE_AF,OTOA
389537,16:21739677:A>ACGG,NM_144672.3:c.2134_2136dup,NP_653273.3:p.Gly712dup,19/28,\N,Unknown significance,\N,inframe_insertion,0.105,0.0000962464,EXAC_AFR_AF,OTOA
389538,16:21739677:A>G,NM_144672.3:c.2132A>G,NP_653273.3:p.His711Arg,19/28,\N,Likely benign,\N,missense_variant,0.016,0.0000449951,EXAC_NFE_AF,OTOA
389539,16:21739678:C>G,NM_144672.3:c.2133C>G,NP_653273.3:p.His711Gln,19/28,\N,Likely benign,\N,missense_variant,0.016,0.000172891,EXAC_AMR_AF,OTOA
389540,16:21739678:C>T,NM_144672.3:c.2133C>T,NP_653273.3:p.His711=,19/28,\N,Unknown significance,\N,synonymous_variant,7.511,0.0014,1KG_AMR_AF,OTOA
389541,16:21739684:C>T,NM_144672.3:c.2139C>T,NP_653273.3:p.Leu713=,19/28,\N,Unknown significance,\N,synonymous_variant,8.764,\N,\N,OTOA
389542,16:21739689:A>C,NM_144672.3:c.2144A>C,NP_653273.3:p.Asp715Ala,19/28,\N,Likely benign,\N,missense_variant,0.021,0.0000150101,EXAC_NFE_AF,OTOA
389543,16:21739695:C>A,NM_144672.3:c.2150C>A,NP_653273.3:p.Pro717Gln,19/28,\N,Likely benign,\N,missense_variant,1.49,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
389544,16:21739698:A>G,NM_144672.3:c.2153A>G,NP_653273.3:p.Asp718Gly,19/28,\N,Likely benign,\N,missense_variant,7.692,0.00090843,EXAC_SAS_AF,OTOA
389545,16:21739706:C>A,NM_144672.3:c.2161C>A,NP_653273.3:p.Pro721Thr,19/28,\N,Likely benign,\N,missense_variant,21.1,0.000060584,EXAC_SAS_AF,OTOA
389546,16:21739720:T>C,NM_144672.3:c.2175T>C,NP_653273.3:p.Ala725=,19/28,\N,Unknown significance,\N,synonymous_variant,0.5,0.0000150798,EXAC_NFE_AF,OTOA
389547,16:21739733:A>C,NM_144672.3:c.2188A>C,NP_653273.3:p.Lys730Gln,19/28,\N,Likely benign,\N,missense_variant,4.694,\N,\N,OTOA
389548,16:21739735:G>A,NM_144672.3:c.2190G>A,NP_653273.3:p.Lys730=,19/28,\N,Unknown significance,\N,synonymous_variant,8.11,0.000174795,EXAC_AMR_AF,OTOA
389549,16:21739742:G>C,NM_144672.3:c.2197G>C,NP_653273.3:p.Gly733Arg,19/28,\N,Unknown significance,\N,missense_variant,22.8,\N,\N,OTOA
389550,16:21739746:A>G,NM_144672.3:c.2201A>G,NP_653273.3:p.Gln734Arg,19/28,\N,Pathogenic,Hearing loss| non-syndromic| autosomal recessive,missense_variant,8.163,0.0000626881,EXAC_SAS_AF,OTOA
389551,16:21739748:T>C,NM_144672.3:c.2203T>C,NP_653273.3:p.Tyr735His,19/28,\N,Likely benign,\N,missense_variant,1.439,0.000124813,EXAC_EAS_AF,OTOA
389552,16:21739752:G>A,NM_144672.3:c.2207G>A,NP_653273.3:p.Gly736Glu,19/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,25.6,0.000106045,EXAC_AFR_AF,OTOA
389553,16:21739755:G>A,NM_144672.3:c.2207+3G>A,\N,\N,19/27,Unknown significance,\N,splice_region_variant&intron_variant,8.626,0.0000330207,EXAC_NFE_AF,OTOA
389554,16:21739760:G>C,NM_144672.3:c.2207+8G>C,\N,\N,19/27,Unknown significance,\N,splice_region_variant&intron_variant,3.049,0.002,1KG_EUR_AF,OTOA
389555,16:21739761:C>T,NM_144672.3:c.2207+9C>T,\N,\N,19/27,Likely benign,\N,intron_variant,1.738,0.000682439,EVS_AA_AF,OTOA
389556,16:21739761:C>A,NM_144672.3:c.2207+9C>A,\N,\N,19/27,Unknown significance,\N,intron_variant,2.637,\N,\N,OTOA
389557,16:21739762:G>A,NM_144672.3:c.2207+10G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,4.723,0.0000355619,EXAC_NFE_AF,OTOA
389558,16:21739767:G>A,NM_144672.3:c.2207+15G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,6.837,0.000202129,EXAC_SAS_AF,OTOA
389559,16:21739779:G>T,NM_144672.3:c.2207+27G>T,\N,\N,19/27,Unknown significance,\N,intron_variant,3.286,0.0000698714,EXAC_SAS_AF,OTOA
389560,16:21739780:G>A,NM_144672.3:c.2207+28G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,2.756,0.0033543,EXAC_SAS_AF,OTOA
389561,16:21739783:G>C,NM_144672.3:c.2207+31G>C,\N,\N,19/27,Unknown significance,\N,intron_variant,0.083,0.0000390976,EXAC_NFE_AF,OTOA
389562,16:21739797:G>A,NM_144672.3:c.2207+45G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,1.502,0.0008,1KG_AFR_AF,OTOA
389563,16:21739799:G>A,NM_144672.3:c.2207+47G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,4.021,0.000224517,EXAC_EAS_AF,OTOA
389564,16:21739807:A>T,NM_144672.3:c.2207+55A>T,\N,\N,19/27,Unknown significance,\N,intron_variant,1.547,\N,\N,OTOA
389565,16:21739812:A>G,NM_144672.3:c.2207+60A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,4.956,\N,\N,OTOA
389566,16:21739912:A>T,NM_144672.3:c.2207+160A>T,\N,\N,19/27,Unknown significance,\N,intron_variant,17.08,\N,\N,OTOA
389567,16:21739912:AT>A,NM_144672.3:c.2207+174del,\N,\N,19/27,Unknown significance,\N,intron_variant,17.78,\N,\N,OTOA
389568,16:21739942:G>A,NM_144672.3:c.2207+190G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,0.175,\N,\N,OTOA
389569,16:21739942:G>T,NM_144672.3:c.2207+190G>T,\N,\N,19/27,Unknown significance,\N,intron_variant,0.068,0.002,1KG_SAS_AF,OTOA
389570,16:21739972:C>T,NM_144672.3:c.2207+220C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,1.757,\N,\N,OTOA
389571,16:21739982:T>C,NM_144672.3:c.2207+230T>C,\N,\N,19/27,Unknown significance,\N,intron_variant,3.462,\N,\N,OTOA
389572,16:21740011:G>C,NM_144672.3:c.2207+259G>C,\N,\N,19/27,Unknown significance,\N,intron_variant,5.643,0.003,1KG_EAS_AF,OTOA
389573,16:21740093:A>G,NM_144672.3:c.2207+341A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,2.148,\N,\N,OTOA
389574,16:21740133:C>T,NM_144672.3:c.2207+381C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,2.424,0.001,1KG_SAS_AF,OTOA
389575,16:21740169:A>G,NM_144672.3:c.2207+417A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,3.283,0.0008,1KG_AFR_AF,OTOA
389576,16:21740196:C>T,NM_144672.3:c.2207+444C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,2.606,0.0014,1KG_AMR_AF,OTOA
389577,16:21740199:C>T,NM_144672.3:c.2207+447C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,0.264,\N,\N,OTOA
389578,16:21740200:G>C,NM_144672.3:c.2207+448G>C,\N,\N,19/27,Unknown significance,\N,intron_variant,0.188,\N,\N,OTOA
389579,16:21740231:T>G,NM_144672.3:c.2207+479T>G,\N,\N,19/27,Unknown significance,\N,intron_variant,4.403,\N,\N,OTOA
389580,16:21740232:G>A,NM_144672.3:c.2207+480G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,1.049,\N,\N,OTOA
389581,16:21740238:A>G,NM_144672.3:c.2207+486A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,2.931,0.002,1KG_EAS_AF,OTOA
389582,16:21740261:CAA>C,NM_144672.3:c.2207+511_2207+512del,\N,\N,19/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389583,16:21740262:A>G,NM_144672.3:c.2207+510A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,5.941,0.001,1KG_SAS_AF,OTOA
389584,16:21740274:C>T,NM_144672.3:c.2207+522C>T,\N,\N,19/27,Benign,\N,intron_variant,5.019,0.2724,1KG_EUR_AF,OTOA
389585,16:21740280:C>G,NM_144672.3:c.2207+528C>G,\N,\N,19/27,Unknown significance,\N,intron_variant,1.764,\N,\N,OTOA
389586,16:21740283:C>T,NM_144672.3:c.2207+531C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,6.825,\N,\N,OTOA
389587,16:21740361:C>T,NM_144672.3:c.2207+609C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,1.84,0.001,1KG_SAS_AF,OTOA
389588,16:21740361:CTA>C,NM_144672.3:c.2207+611_2207+612del,\N,\N,19/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389589,16:21740362:T>G,NM_144672.3:c.2207+610T>G,\N,\N,19/27,Unknown significance,\N,intron_variant,2.488,0.0008,1KG_AFR_AF,OTOA
389590,16:21740363:A>AT,NM_144672.3:c.2207+621dup,\N,\N,19/27,Benign,\N,intron_variant,0.167,0.3688,1KG_EUR_AF,OTOA
389591,16:21740374:A>T,NM_144672.3:c.2207+622A>T,\N,\N,19/27,Unknown significance,\N,intron_variant,0.733,\N,\N,OTOA
389592,16:21740377:T>A,NM_144672.3:c.2207+625T>A,\N,\N,19/27,Unknown significance,\N,intron_variant,1.225,\N,\N,OTOA
389593,16:21740467:C>T,NM_144672.3:c.2207+715C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,1.654,\N,\N,OTOA
389594,16:21740472:G>C,NM_144672.3:c.2207+720G>C,\N,\N,19/27,Benign,\N,intron_variant,0.036,0.0119,1KG_EAS_AF,OTOA
389595,16:21740496:C>T,NM_144672.3:c.2207+744C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,6.203,\N,\N,OTOA
389596,16:21740524:T>G,NM_144672.3:c.2207+772T>G,\N,\N,19/27,Unknown significance,\N,intron_variant,4.654,0.001,1KG_SAS_AF,OTOA
389597,16:21740575:C>T,NM_144672.3:c.2207+823C>T,\N,\N,19/27,Benign,\N,intron_variant,11.34,0.008,1KG_EUR_AF,OTOA
389598,16:21740650:G>C,NM_144672.3:c.2207+898G>C,\N,\N,19/27,Unknown significance,\N,intron_variant,0.925,0.001,1KG_EAS_AF,OTOA
389599,16:21740663:G>A,NM_144672.3:c.2207+911G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,2.249,0.0014,1KG_AMR_AF,OTOA
389600,16:21740736:C>T,NM_144672.3:c.2207+984C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,0.656,\N,\N,OTOA
389601,16:21740737:G>A,NM_144672.3:c.2207+985G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,1.355,0.002,1KG_EAS_AF,OTOA
389602,16:21740742:C>T,NM_144672.3:c.2207+990C>T,\N,\N,19/27,Benign,\N,intron_variant,0.299,0.0109,1KG_EUR_AF,OTOA
389603,16:21740743:G>A,NM_144672.3:c.2207+991G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,1.302,\N,\N,OTOA
389604,16:21740795:A>G,NM_144672.3:c.2207+1043A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,5.237,0.002,1KG_EUR_AF,OTOA
389605,16:21740796:CT>C,NM_144672.3:c.2207+1045del,\N,\N,19/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389606,16:21740821:G>A,NM_144672.3:c.2207+1069G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,4.63,\N,\N,OTOA
389607,16:21740846:T>A,NM_144672.3:c.2207+1094T>A,\N,\N,19/27,Unknown significance,\N,intron_variant,3.553,\N,\N,OTOA
389608,16:21740866:G>A,NM_144672.3:c.2207+1114G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,4.371,0.0008,1KG_AFR_AF,OTOA
389609,16:21740867:A>G,NM_144672.3:c.2207+1115A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,1.194,\N,\N,OTOA
389610,16:21740919:T>G,NM_144672.3:c.2207+1167T>G,\N,\N,19/27,Unknown significance,\N,intron_variant,2.059,\N,\N,OTOA
389611,16:21740929:A>G,NM_144672.3:c.2207+1177A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,6.21,0.0008,1KG_AFR_AF,OTOA
389612,16:21740938:T>C,NM_144672.3:c.2207+1186T>C,\N,\N,19/27,Benign,\N,intron_variant,3.859,0.0249,1KG_EUR_AF,OTOA
389613,16:21740943:C>T,NM_144672.3:c.2207+1191C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,0.649,\N,\N,OTOA
389614,16:21740956:C>G,NM_144672.3:c.2208-1202C>G,\N,\N,19/27,Unknown significance,\N,intron_variant,2.26,\N,\N,OTOA
389615,16:21740974:C>T,NM_144672.3:c.2208-1184C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,0.647,0.0015,1KG_AFR_AF,OTOA
389616,16:21740975:G>A,NM_144672.3:c.2208-1183G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,0.702,\N,\N,OTOA
389617,16:21741000:C>T,NM_144672.3:c.2208-1158C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,3.879,\N,\N,OTOA
389618,16:21741003:T>A,NM_144672.3:c.2208-1155T>A,\N,\N,19/27,Unknown significance,\N,intron_variant,8.259,0.0008,1KG_AFR_AF,OTOA
389619,16:21741042:A>G,NM_144672.3:c.2208-1116A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,3.51,0.0014,1KG_AMR_AF,OTOA
389620,16:21741058:G>A,NM_144672.3:c.2208-1100G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,4.161,\N,\N,OTOA
389621,16:21741063:C>T,NM_144672.3:c.2208-1095C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,3.262,0.001,1KG_EUR_AF,OTOA
389622,16:21741141:G>T,NM_144672.3:c.2208-1017G>T,\N,\N,19/27,Unknown significance,\N,intron_variant,6.929,0.001,1KG_SAS_AF,OTOA
389623,16:21741153:A>G,NM_144672.3:c.2208-1005A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,7.322,0.001,1KG_EAS_AF,OTOA
389624,16:21741194:A>G,NM_144672.3:c.2208-964A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,3.839,0.001,1KG_EAS_AF,OTOA
389625,16:21741234:G>A,NM_144672.3:c.2208-924G>A,\N,\N,19/27,Benign,\N,intron_variant,2.938,0.115,1KG_AFR_AF,OTOA
389626,16:21741273:A>G,NM_144672.3:c.2208-885A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,7.564,0.0014,1KG_AMR_AF,OTOA
389627,16:21741316:A>T,NM_144672.3:c.2208-842A>T,\N,\N,19/27,Unknown significance,\N,intron_variant,0.805,0.001,1KG_SAS_AF,OTOA
389628,16:21741397:A>T,NM_144672.3:c.2208-761A>T,\N,\N,19/27,Unknown significance,\N,intron_variant,0.09,0.0031,1KG_SAS_AF,OTOA
389629,16:21741465:T>C,NM_144672.3:c.2208-693T>C,\N,\N,19/27,Unknown significance,\N,intron_variant,2.347,0.0008,1KG_AFR_AF,OTOA
389630,16:21741476:C>T,NM_144672.3:c.2208-682C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,6.912,0.0023,1KG_AFR_AF,OTOA
389631,16:21741477:G>A,NM_144672.3:c.2208-681G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,4.468,\N,\N,OTOA
389632,16:21741656:T>C,NM_144672.3:c.2208-502T>C,\N,\N,19/27,Unknown significance,\N,intron_variant,0.641,0.0008,1KG_AFR_AF,OTOA
389633,16:21741657:G>T,NM_144672.3:c.2208-501G>T,\N,\N,19/27,Unknown significance,\N,intron_variant,0.382,0.0008,1KG_AFR_AF,OTOA
389634,16:21741729:C>T,NM_144672.3:c.2208-429C>T,\N,\N,19/27,Unknown significance,\N,intron_variant,1.549,\N,\N,OTOA
389635,16:21741730:G>T,NM_144672.3:c.2208-428G>T,\N,\N,19/27,Unknown significance,\N,intron_variant,0.413,0.003,1KG_AFR_AF,OTOA
389636,16:21741797:A>T,NM_144672.3:c.2208-361A>T,\N,\N,19/27,Unknown significance,\N,intron_variant,4.078,\N,\N,OTOA
389637,16:21741842:C>A,NM_144672.3:c.2208-316C>A,\N,\N,19/27,Unknown significance,\N,intron_variant,4.05,0.0014,1KG_AMR_AF,OTOA
389638,16:21741856:T>C,NM_144672.3:c.2208-302T>C,\N,\N,19/27,Unknown significance,\N,intron_variant,5.743,0.001,1KG_SAS_AF,OTOA
389639,16:21741890:A>G,NM_144672.3:c.2208-268A>G,\N,\N,19/27,Unknown significance,\N,intron_variant,1.584,0.001,1KG_EUR_AF,OTOA
389640,16:21741934:AG>A,NM_144672.3:c.2208-223del,\N,\N,19/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389641,16:21741937:G>A,NM_144672.3:c.2208-221G>A,\N,\N,19/27,Benign,\N,intron_variant,6.495,0.005,1KG_EUR_AF,OTOA
389642,16:21742020:T>C,NM_144672.3:c.2208-138T>C,\N,\N,19/27,Unknown significance,\N,intron_variant,1.831,\N,\N,OTOA
389643,16:21742036:AC>A,NM_144672.3:c.2208-120del,\N,\N,19/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389644,16:21742068:A>G,NM_144672.3:c.2208-90A>G,\N,\N,19/27,Benign,\N,intron_variant,2.001,0.0068,1KG_AFR_AF,OTOA
389645,16:21742093:G>A,NM_144672.3:c.2208-65G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,4.459,0.001,1KG_SAS_AF,OTOA
389646,16:21742111:C>A,NM_144672.3:c.2208-47C>A,\N,\N,19/27,Unknown significance,\N,intron_variant,7.077,\N,\N,OTOA
389647,16:21742124:T>C,NM_144672.3:c.2208-34T>C,\N,\N,19/27,Unknown significance,\N,intron_variant,0.249,0.0008,1KG_AFR_AF,OTOA
389648,16:21742124:T>G,NM_144672.3:c.2208-34T>G,\N,\N,19/27,Unknown significance,\N,intron_variant,0.466,\N,\N,OTOA
389649,16:21742140:G>A,NM_144672.3:c.2208-18G>A,\N,\N,19/27,Unknown significance,\N,intron_variant,3.026,\N,\N,OTOA
389650,16:21742147:T>C,NM_144672.3:c.2208-11T>C,\N,\N,19/27,Unknown significance,\N,intron_variant,6.522,\N,\N,OTOA
389651,16:21742151:T>G,NM_144672.3:c.2208-7T>G,\N,\N,19/27,Unknown significance,\N,splice_region_variant&intron_variant,5.248,\N,\N,OTOA
389652,16:21742157:G>A,NM_144672.3:c.2208-1G>A,\N,\N,19/27,Pathogenic,Hearing loss| non-syndromic| autosomal recessive,splice_acceptor_variant,22.4,\N,\N,OTOA
389653,16:21742158:A>G,NM_144672.3:c.2208A>G,NP_653273.3:p.Gly736=,20/28,\N,Unknown significance,\N,splice_region_variant&synonymous_variant,1.713,\N,\N,OTOA
389654,16:21742172:G>C,NM_144672.3:c.2222G>C,NP_653273.3:p.Trp741Ser,20/28,\N,Unknown significance,\N,missense_variant,27.5,\N,\N,OTOA
389655,16:21742175:C>A,NM_144672.3:c.2225C>A,NP_653273.3:p.Thr742Lys,20/28,\N,Unknown significance,\N,missense_variant,29.4,\N,\N,OTOA
389656,16:21742179:C>T,NM_144672.3:c.2229C>T,NP_653273.3:p.Ala743=,20/28,\N,Benign,\N,synonymous_variant,14.21,0.03125,OTO_CO_AF,OTOA
389657,16:21742186:AC>A,NM_144672.3:c.2237del,NP_653273.3:p.Thr746ArgfsTer8,20/28,\N,Unknown significance,\N,frameshift_variant,24.2,0.0000155579,EXAC_NFE_AF,OTOA
389658,16:21742187:C>T,NM_144672.3:c.2237C>T,NP_653273.3:p.Thr746Met,20/28,\N,Likely benign,\N,missense_variant,12.03,\N,\N,OTOA
389659,16:21742188:G>A,NM_144672.3:c.2238G>A,NP_653273.3:p.Thr746=,20/28,\N,Benign,\N,synonymous_variant,8.036,0.4625,OTO_JP_AF,OTOA
389660,16:21742197:G>C,NM_170664.2:c.1275G>C,NP_733764.1:p.Leu425Phe,11/19,\N,Unknown significance,\N,missense_variant,25.8,\N,\N,OTOA
389661,16:21742207:C>T,NM_144672.3:c.2257C>T,NP_653273.3:p.Leu753=,20/28,\N,Unknown significance,\N,synonymous_variant,13.9,\N,\N,OTOA
389662,16:21742240:A>G,NM_144672.3:c.2290A>G,NP_653273.3:p.Ile764Val,20/28,\N,Likely benign,\N,missense_variant,4.261,\N,\N,OTOA
389663,16:21742243:GC>G,NM_144672.3:c.2295del,NP_653273.3:p.Thr766GlnfsTer99,20/28,\N,Unknown significance,\N,frameshift_variant,33,0.00143904,EXAC_AFR_AF,OTOA
389664,16:21742247:C>G,NM_144672.3:c.2297C>G,NP_653273.3:p.Thr766Arg,20/28,\N,Likely benign,\N,missense_variant,18.46,\N,\N,OTOA
389665,16:21742250:A>G,NM_144672.3:c.2300A>G,NP_653273.3:p.Lys767Arg,20/28,\N,Unknown significance,\N,missense_variant&splice_region_variant,25.3,\N,\N,OTOA
389666,16:21742253:T>A,NM_144672.3:c.2301+2T>A,\N,\N,20/27,Unknown significance,\N,splice_donor_variant,23.6,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
389667,16:21742254:A>T,NM_144672.3:c.2301+3A>T,\N,\N,20/27,Benign,\N,splice_region_variant&intron_variant,10.42,0.00625,OTO_US_AF,OTOA
389668,16:21742255:ATGT>A,NM_144672.3:c.2301+8_2301+10del,\N,\N,20/27,Unknown significance,\N,splice_region_variant&intron_variant,5.12,0.000143143,EXAC_AFR_AF,OTOA
389669,16:21742259:T>G,NM_144672.3:c.2301+8T>G,\N,\N,20/27,Unknown significance,\N,splice_region_variant&intron_variant,3.217,\N,\N,OTOA
389670,16:21742274:G>C,NM_144672.3:c.2301+23G>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.577,\N,\N,OTOA
389671,16:21742291:G>C,NM_144672.3:c.2301+40G>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.318,\N,\N,OTOA
389672,16:21742297:G>T,NM_144672.3:c.2301+46G>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.601,0.001,1KG_EAS_AF,OTOA
389673,16:21742353:A>G,NM_144672.3:c.2301+102A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,3.954,0.002,1KG_SAS_AF,OTOA
389674,16:21742381:G>A,NM_144672.3:c.2301+130G>A,\N,\N,20/27,Benign,\N,intron_variant,7.336,0.0068,1KG_AFR_AF,OTOA
389675,16:21742383:T>A,NM_144672.3:c.2301+132T>A,\N,\N,20/27,Unknown significance,\N,intron_variant,8.468,0.001,1KG_EAS_AF,OTOA
389676,16:21742383:TG>T,NM_144672.3:c.2301+133del,\N,\N,20/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389677,16:21742470:C>G,NM_144672.3:c.2301+219C>G,\N,\N,20/27,Benign,\N,intron_variant,1.433,0.0091,1KG_AFR_AF,OTOA
389678,16:21742504:G>A,NM_144672.3:c.2301+253G>A,\N,\N,20/27,Benign,\N,intron_variant,5.879,0.0091,1KG_AFR_AF,OTOA
389679,16:21742516:C>T,NM_144672.3:c.2301+265C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,7.522,0.001,1KG_SAS_AF,OTOA
389680,16:21742540:C>T,NM_144672.3:c.2301+289C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.996,\N,\N,OTOA
389681,16:21742542:T>C,NM_144672.3:c.2301+291T>C,\N,\N,20/27,Benign,\N,intron_variant,0.298,0.4467,1KG_AMR_AF,OTOA
389682,16:21742568:T>A,NM_144672.3:c.2301+317T>A,\N,\N,20/27,Unknown significance,\N,intron_variant,5.239,\N,\N,OTOA
389683,16:21742568:T>G,NM_144672.3:c.2301+317T>G,\N,\N,20/27,Unknown significance,\N,intron_variant,3.848,\N,\N,OTOA
389684,16:21742649:G>C,NM_144672.3:c.2301+398G>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.179,0.001,1KG_EAS_AF,OTOA
389685,16:21742658:AT>A,NM_144672.3:c.2301+410del,\N,\N,20/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389686,16:21742669:A>T,NM_144672.3:c.2301+418A>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.794,\N,\N,OTOA
389687,16:21742670:C>T,NM_144672.3:c.2301+419C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.191,0.001,1KG_EAS_AF,OTOA
389688,16:21742690:T>C,NM_144672.3:c.2301+439T>C,\N,\N,20/27,Benign,\N,intron_variant,0.91,0.1895,1KG_EAS_AF,OTOA
389689,16:21742716:G>C,NM_144672.3:c.2301+465G>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.979,0.0014,1KG_AMR_AF,OTOA
389690,16:21742719:G>T,NM_144672.3:c.2301+468G>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.067,0.0008,1KG_AFR_AF,OTOA
389691,16:21742721:A>C,NM_144672.3:c.2301+470A>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.66,0.0008,1KG_AFR_AF,OTOA
389692,16:21742738:A>G,NM_144672.3:c.2301+487A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,1.933,0.001,1KG_EAS_AF|1KG_SAS_AF,OTOA
389693,16:21742776:C>T,NM_144672.3:c.2301+525C>T,\N,\N,20/27,Benign,\N,intron_variant,5.717,0.0053,1KG_AFR_AF,OTOA
389694,16:21742794:C>T,NM_144672.3:c.2301+543C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.249,0.001,1KG_EUR_AF,OTOA
389695,16:21742804:C>T,NM_144672.3:c.2301+553C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,4.322,\N,\N,OTOA
389696,16:21742826:C>T,NM_144672.3:c.2301+575C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,4.847,0.001,1KG_EAS_AF,OTOA
389697,16:21742827:G>A,NM_144672.3:c.2301+576G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.2,0.002,1KG_EAS_AF,OTOA
389698,16:21742850:CTTGT>C,NM_144672.3:c.2301+602_2301+605del,\N,\N,20/27,Benign,\N,intron_variant,2.264,0.005,1KG_EAS_AF,OTOA
389699,16:21742861:T>C,NM_144672.3:c.2301+610T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,2.265,\N,\N,OTOA
389700,16:21742873:A>G,NM_144672.3:c.2301+622A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,1.675,\N,\N,OTOA
389701,16:21742890:G>A,NM_144672.3:c.2301+639G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,4.019,0.0008,1KG_AFR_AF,OTOA
389702,16:21742939:C>T,NM_144672.3:c.2301+688C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.011,0.001,1KG_EAS_AF,OTOA
389703,16:21742940:G>A,NM_144672.3:c.2301+689G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.763,\N,\N,OTOA
389704,16:21742944:T>C,NM_144672.3:c.2301+693T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,2.559,\N,\N,OTOA
389705,16:21742986:C>T,NM_144672.3:c.2301+735C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.932,0.001,1KG_EAS_AF,OTOA
389706,16:21743048:A>C,NM_144672.3:c.2301+797A>C,\N,\N,20/27,Benign,\N,intron_variant,1.606,0.0303,1KG_AFR_AF,OTOA
389707,16:21743053:A>G,NM_144672.3:c.2301+802A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,3.514,0.001,1KG_SAS_AF,OTOA
389708,16:21743104:C>T,NM_144672.3:c.2301+853C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,4.391,0.0023,1KG_AFR_AF,OTOA
389709,16:21743130:G>A,NM_144672.3:c.2301+879G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.414,0.001,1KG_EUR_AF,OTOA
389710,16:21743145:T>A,NM_144672.3:c.2301+894T>A,\N,\N,20/27,Unknown significance,\N,intron_variant,2.245,\N,\N,OTOA
389711,16:21743151:G>A,NM_144672.3:c.2301+900G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,5.428,0.0008,1KG_AFR_AF,OTOA
389712,16:21743169:C>T,NM_144672.3:c.2301+918C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.98,0.0008,1KG_AFR_AF,OTOA
389713,16:21743193:G>GCA,NM_144672.3:c.2301+945_2301+946dup,\N,\N,20/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389714,16:21743205:G>C,NM_144672.3:c.2301+954G>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.488,\N,\N,OTOA
389715,16:21743269:CAT>C,NM_144672.3:c.2301+1019_2301+1020del,\N,\N,20/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389716,16:21743407:C>T,NM_144672.3:c.2301+1156C>T,\N,\N,20/27,Benign,\N,intron_variant,0.345,0.0437,1KG_EAS_AF,OTOA
389717,16:21743442:A>G,NM_144672.3:c.2301+1191A>G,\N,\N,20/27,Benign,\N,intron_variant,1.855,0.2704,1KG_EUR_AF,OTOA
389718,16:21743466:T>C,NM_144672.3:c.2301+1215T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,1.263,0.001,1KG_EUR_AF,OTOA
389719,16:21743477:G>A,NM_144672.3:c.2301+1226G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,1.385,\N,\N,OTOA
389720,16:21743551:G>A,NM_144672.3:c.2301+1300G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.314,0.004,1KG_EAS_AF,OTOA
389721,16:21743563:G>C,NM_144672.3:c.2301+1312G>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.359,0.001,1KG_SAS_AF,OTOA
389722,16:21743565:C>T,NM_144672.3:c.2301+1314C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.598,0.001,1KG_EUR_AF,OTOA
389723,16:21743566:G>A,NM_144672.3:c.2301+1315G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.172,0.0008,1KG_AFR_AF,OTOA
389724,16:21743592:C>A,NM_144672.3:c.2301+1341C>A,\N,\N,20/27,Benign,\N,intron_variant,0.571,0.3108,1KG_SAS_AF,OTOA
389725,16:21743709:T>A,NM_144672.3:c.2301+1458T>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.988,\N,\N,OTOA
389726,16:21743748:C>T,NM_144672.3:c.2301+1497C>T,\N,\N,20/27,Benign,\N,intron_variant,1.9,0.3006,1KG_SAS_AF,OTOA
389727,16:21743762:A>G,NM_144672.3:c.2301+1511A>G,\N,\N,20/27,Benign,\N,intron_variant,2.175,0.2986,1KG_SAS_AF,OTOA
389728,16:21743770:C>A,NM_144672.3:c.2301+1519C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,1.907,0.001,1KG_EAS_AF,OTOA
389729,16:21743818:C>T,NM_144672.3:c.2301+1567C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,3.729,\N,\N,OTOA
389730,16:21743828:C>A,NM_144672.3:c.2301+1577C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,5.126,0.0014,1KG_AMR_AF,OTOA
389731,16:21743836:C>T,NM_144672.3:c.2301+1585C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,3.184,\N,\N,OTOA
389732,16:21743905:A>G,NM_144672.3:c.2301+1654A>G,\N,\N,20/27,Benign,\N,intron_variant,8.812,0.0239,1KG_EUR_AF,OTOA
389733,16:21743955:C>T,NM_144672.3:c.2301+1704C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,4.82,\N,\N,OTOA
389734,16:21744070:T>G,NM_144672.3:c.2301+1819T>G,\N,\N,20/27,Unknown significance,\N,intron_variant,7.527,\N,\N,OTOA
389735,16:21744079:T>A,NM_144672.3:c.2301+1828T>A,\N,\N,20/27,Unknown significance,\N,intron_variant,7.562,0.0008,1KG_AFR_AF,OTOA
389736,16:21744086:C>A,NM_144672.3:c.2301+1835C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,3.749,0.001,1KG_EAS_AF,OTOA
389737,16:21744183:A>C,NM_144672.3:c.2301+1932A>C,\N,\N,20/27,Unknown significance,\N,intron_variant,9.707,0.001,1KG_SAS_AF,OTOA
389738,16:21744230:A>G,NM_144672.3:c.2301+1979A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,9.908,\N,\N,OTOA
389739,16:21744328:C>A,NM_144672.3:c.2301+2077C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,1.361,0.001,1KG_SAS_AF,OTOA
389740,16:21744361:C>G,NM_144672.3:c.2301+2110C>G,\N,\N,20/27,Benign,\N,intron_variant,6.779,0.0076,1KG_AFR_AF,OTOA
389741,16:21744479:G>C,NM_144672.3:c.2301+2228G>C,\N,\N,20/27,Benign,\N,intron_variant,0.038,0.0567,1KG_EUR_AF,OTOA
389742,16:21744503:G>A,NM_144672.3:c.2301+2252G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,3.444,\N,\N,OTOA
389743,16:21744505:C>A,NM_144672.3:c.2301+2254C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,3.134,0.0008,1KG_AFR_AF,OTOA
389744,16:21744708:TA>T,NM_144672.3:c.2301+2458del,\N,\N,20/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389745,16:21744717:C>T,NM_144672.3:c.2301+2466C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,2.213,\N,\N,OTOA
389746,16:21744722:C>T,NM_144672.3:c.2301+2471C>T,\N,\N,20/27,Benign,\N,intron_variant,0.662,0.0865,1KG_AMR_AF,OTOA
389747,16:21744731:C>G,NM_144672.3:c.2301+2480C>G,\N,\N,20/27,Unknown significance,\N,intron_variant,2.88,\N,\N,OTOA
389748,16:21744758:G>C,NM_144672.3:c.2301+2507G>C,\N,\N,20/27,Benign,\N,intron_variant,2.279,0.3938,1KG_EAS_AF,OTOA
389749,16:21744779:C>T,NM_144672.3:c.2301+2528C>T,\N,\N,20/27,Benign,\N,intron_variant,2.358,0.2714,1KG_EUR_AF,OTOA
389750,16:21744786:G>T,NM_144672.3:c.2301+2535G>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.068,0.001,1KG_EUR_AF,OTOA
389751,16:21744824:T>C,NM_144672.3:c.2301+2573T>C,\N,\N,20/27,Benign,\N,intron_variant,9.967,0.093,1KG_AFR_AF,OTOA
389752,16:21744873:C>T,NM_144672.3:c.2301+2622C>T,\N,\N,20/27,Benign,\N,intron_variant,0.967,0.0953,1KG_AFR_AF,OTOA
389753,16:21744982:C>T,NM_144672.3:c.2302-2600C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.436,0.001,1KG_EAS_AF,OTOA
389754,16:21745074:C>G,NM_144672.3:c.2302-2508C>G,\N,\N,20/27,Unknown significance,\N,intron_variant,2.183,\N,\N,OTOA
389755,16:21745155:G>C,NM_144672.3:c.2302-2427G>C,\N,\N,20/27,Benign,\N,intron_variant,0.322,0.0068,1KG_AFR_AF,OTOA
389756,16:21745167:CCG>ACA,NM_144672.3:c.2302-2415_2302-2413delinsACA,\N,\N,20/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389757,16:21745168:C>T,NM_144672.3:c.2302-2414C>T,\N,\N,20/27,Benign,\N,intron_variant,0.187,0.0235,1KG_SAS_AF,OTOA
389758,16:21745169:G>A,NM_144672.3:c.2302-2413G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.193,0.001,1KG_SAS_AF,OTOA
389759,16:21745183:C>T,NM_144672.3:c.2302-2399C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.22,\N,\N,OTOA
389760,16:21745189:C>T,NM_144672.3:c.2302-2393C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.335,0.0029,1KG_AMR_AF,OTOA
389761,16:21745207:A>G,NM_144672.3:c.2302-2375A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,1.182,\N,\N,OTOA
389762,16:21745247:A>G,NM_144672.3:c.2302-2335A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,4.715,\N,\N,OTOA
389763,16:21745248:G>A,NM_144672.3:c.2302-2334G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,4.492,\N,\N,OTOA
389764,16:21745261:T>C,NM_144672.3:c.2302-2321T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,1.706,\N,\N,OTOA
389765,16:21745261:TAGGCATACACCACCAT>CAGGCATACATCACCAC,NM_144672.3:c.2302-2321_2302-2305delinsCAGGCATACATCACCAC,\N,\N,20/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389766,16:21745271:C>T,NM_144672.3:c.2302-2311C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,2.389,\N,\N,OTOA
389767,16:21745277:T>C,NM_144672.3:c.2302-2305T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.026,\N,\N,OTOA
389768,16:21745280:C>T,NM_144672.3:c.2302-2302C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.515,\N,\N,OTOA
389769,16:21745309:C>T,NM_144672.3:c.2302-2273C>T,\N,\N,20/27,Benign,\N,intron_variant,0.26,0.0051,1KG_SAS_AF,OTOA
389770,16:21745321:G>A,NM_144672.3:c.2302-2261G>A,\N,\N,20/27,Benign,\N,intron_variant,0.163,0.0061,1KG_SAS_AF,OTOA
389771,16:21745374:G>C,NM_144672.3:c.2302-2208G>C,\N,\N,20/27,Unknown significance,\N,intron_variant,2.157,0.001,1KG_EAS_AF,OTOA
389772,16:21745419:C>A,NM_144672.3:c.2302-2163C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,9.081,0.001,1KG_EUR_AF,OTOA
389773,16:21745438:C>A,NM_144672.3:c.2302-2144C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,10.56,0.001,1KG_EUR_AF,OTOA
389774,16:21745528:C>T,NM_144672.3:c.2302-2054C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,13.05,0.003,1KG_EUR_AF,OTOA
389775,16:21745529:G>A,NM_144672.3:c.2302-2053G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,12.46,\N,\N,OTOA
389776,16:21745649:C>T,NM_144672.3:c.2302-1933C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.755,0.001,1KG_EAS_AF,OTOA
389777,16:21745663:A>C,NM_144672.3:c.2302-1919A>C,\N,\N,20/27,Unknown significance,\N,intron_variant,4.849,0.001,1KG_EUR_AF,OTOA
389778,16:21745692:A>C,NM_144672.3:c.2302-1890A>C,\N,\N,20/27,Unknown significance,\N,intron_variant,3.768,0.001,1KG_EAS_AF,OTOA
389779,16:21745700:A>G,NM_144672.3:c.2302-1882A>G,\N,\N,20/27,Benign,\N,intron_variant,2.333,0.2975,1KG_SAS_AF,OTOA
389780,16:21745755:C>A,NM_144672.3:c.2302-1827C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,4.152,0.001,1KG_EAS_AF,OTOA
389781,16:21745804:C>T,NM_144672.3:c.2302-1778C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,10.6,0.001,1KG_EAS_AF,OTOA
389782,16:21745820:G>A,NM_144672.3:c.2302-1762G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,11.75,0.003,1KG_EUR_AF,OTOA
389783,16:21745828:C>A,NM_144672.3:c.2302-1754C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,12.09,0.001,1KG_SAS_AF,OTOA
389784,16:21745862:A>G,NM_144672.3:c.2302-1720A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,0.2,\N,\N,OTOA
389785,16:21745865:A>G,NM_144672.3:c.2302-1717A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,0.793,0.0008,1KG_AFR_AF,OTOA
389786,16:21745870:A>G,NM_144672.3:c.2302-1712A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,0.939,\N,\N,OTOA
389787,16:21745923:C>T,NM_144672.3:c.2302-1659C>T,\N,\N,20/27,Benign,\N,intron_variant,0.401,0.0069,1KG_EAS_AF,OTOA
389788,16:21745927:G>A,NM_144672.3:c.2302-1655G>A,\N,\N,20/27,Benign,\N,intron_variant,2.136,0.0153,1KG_SAS_AF,OTOA
389789,16:21745939:C>T,NM_144672.3:c.2302-1643C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.768,0.001,1KG_EUR_AF,OTOA
389790,16:21745960:G>A,NM_144672.3:c.2302-1622G>A,\N,\N,20/27,Benign,\N,intron_variant,0.113,0.006,1KG_EAS_AF,OTOA
389791,16:21745971:G>T,NM_144672.3:c.2302-1611G>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.074,0.001,1KG_EUR_AF,OTOA
389792,16:21745974:G>A,NM_144672.3:c.2302-1608G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.546,0.001,1KG_SAS_AF,OTOA
389793,16:21745991:A>G,NM_144672.3:c.2302-1591A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,0.349,0.0045,1KG_AFR_AF,OTOA
389794,16:21745993:T>TA,NM_144672.3:c.2302-1583dup,\N,\N,20/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389795,16:21746000:T>C,NM_144672.3:c.2302-1582T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.251,\N,\N,OTOA
389796,16:21746014:C>T,NM_144672.3:c.2302-1568C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.365,\N,\N,OTOA
389797,16:21746031:A>G,NM_144672.3:c.2302-1551A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,2.8,\N,\N,OTOA
389798,16:21746036:T>C,NM_144672.3:c.2302-1546T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,2.048,\N,\N,OTOA
389799,16:21746051:G>A,NM_144672.3:c.2302-1531G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.276,0.0043,1KG_AMR_AF,OTOA
389800,16:21746074:C>T,NM_144672.3:c.2302-1508C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,2.006,\N,\N,OTOA
389801,16:21746075:G>A,NM_144672.3:c.2302-1507G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.216,0.001,1KG_SAS_AF,OTOA
389802,16:21746090:A>G,NM_144672.3:c.2302-1492A>G,\N,\N,20/27,Benign,\N,intron_variant,0.54,0.0159,1KG_EUR_AF,OTOA
389803,16:21746119:T>C,NM_144672.3:c.2302-1463T>C,\N,\N,20/27,Benign,\N,intron_variant,0.268,0.006,1KG_EAS_AF,OTOA
389804,16:21746127:A>G,NM_144672.3:c.2302-1455A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,3.144,\N,\N,OTOA
389805,16:21746128:G>C,NM_144672.3:c.2302-1454G>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.712,\N,\N,OTOA
389806,16:21746141:A>G,NM_144672.3:c.2302-1441A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,1.064,\N,\N,OTOA
389807,16:21746143:C>T,NM_144672.3:c.2302-1439C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.576,0.0029,1KG_AMR_AF,OTOA
389808,16:21746144:G>A,NM_144672.3:c.2302-1438G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,1.279,0.001,1KG_EUR_AF,OTOA
389809,16:21746151:C>T,NM_144672.3:c.2302-1431C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.218,\N,\N,OTOA
389810,16:21746155:TAAAC>T,NM_144672.3:c.2302-1409_2302-1406del,\N,\N,20/27,Unknown significance,\N,intron_variant,3.924,\N,\N,OTOA
389811,16:21746161:A>G,NM_144672.3:c.2302-1421A>G,\N,\N,20/27,Benign,\N,intron_variant,3.545,0.0499,1KG_AFR_AF,OTOA
389812,16:21746192:G>A,NM_144672.3:c.2302-1390G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,4.729,\N,\N,OTOA
389813,16:21746195:C>T,NM_144672.3:c.2302-1387C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,4.887,0.001,1KG_EAS_AF,OTOA
389814,16:21746199:T>A,NM_144672.3:c.2302-1383T>A,\N,\N,20/27,Unknown significance,\N,intron_variant,1.493,0.001,1KG_EUR_AF,OTOA
389815,16:21746215:T>C,NM_144672.3:c.2302-1367T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,4.723,0.001,1KG_EAS_AF,OTOA
389816,16:21746218:G>A,NM_144672.3:c.2302-1364G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,5.403,0.001,1KG_EAS_AF,OTOA
389817,16:21746225:C>T,NM_144672.3:c.2302-1357C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,7.076,0.002,1KG_SAS_AF,OTOA
389818,16:21746235:G>A,NM_144672.3:c.2302-1347G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,7.651,0.001,1KG_SAS_AF,OTOA
389819,16:21746303:T>TAA,NM_144672.3:c.2302-1271_2302-1270dup,\N,\N,20/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389820,16:21746307:A>C,NM_144672.3:c.2302-1275A>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.185,0.0031,1KG_SAS_AF,OTOA
389821,16:21746336:C>T,NM_144672.3:c.2302-1246C>T,\N,\N,20/27,Benign,\N,intron_variant,4.442,0.0437,1KG_EAS_AF,OTOA
389822,16:21746403:A>G,NM_144672.3:c.2302-1179A>G,\N,\N,20/27,Benign,\N,intron_variant,11.78,0.007,1KG_EUR_AF,OTOA
389823,16:21746419:A>G,NM_144672.3:c.2302-1163A>G,\N,\N,20/27,Benign,\N,intron_variant,4.254,0.098,1KG_AMR_AF,OTOA
389824,16:21746505:A>G,NM_144672.3:c.2302-1077A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,2.275,\N,\N,OTOA
389825,16:21746542:A>C,NM_144672.3:c.2302-1040A>C,\N,\N,20/27,Unknown significance,\N,intron_variant,1.642,0.0008,1KG_AFR_AF,OTOA
389826,16:21746569:G>A,NM_144672.3:c.2302-1013G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,3.635,\N,\N,OTOA
389827,16:21746588:G>A,NM_144672.3:c.2302-994G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,0.181,0.001,1KG_EAS_AF,OTOA
389828,16:21746594:C>T,NM_144672.3:c.2302-988C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,1.645,0.001,1KG_EUR_AF,OTOA
389829,16:21746642:G>A,NM_144672.3:c.2302-940G>A,\N,\N,20/27,Benign,\N,intron_variant,0.988,0.2714,1KG_EUR_AF,OTOA
389830,16:21746656:G>A,NM_144672.3:c.2302-926G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,1.915,\N,\N,OTOA
389831,16:21746666:T>C,NM_144672.3:c.2302-916T>C,\N,\N,20/27,Benign,\N,intron_variant,1.25,0.0061,1KG_SAS_AF,OTOA
389832,16:21746682:T>A,NM_144672.3:c.2302-900T>A,\N,\N,20/27,Unknown significance,\N,intron_variant,4.332,0.0029,1KG_AMR_AF,OTOA
389833,16:21746691:C>T,NM_144672.3:c.2302-891C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.156,0.002,1KG_EAS_AF,OTOA
389834,16:21746725:T>C,NM_144672.3:c.2302-857T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,10.53,0.001,1KG_SAS_AF,OTOA
389835,16:21746797:T>C,NM_144672.3:c.2302-785T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,8.176,0.001,1KG_EAS_AF,OTOA
389836,16:21746831:A>G,NM_144672.3:c.2302-751A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,7.465,0.002,1KG_SAS_AF,OTOA
389837,16:21746841:A>G,NM_144672.3:c.2302-741A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,1.644,\N,\N,OTOA
389838,16:21746846:G>A,NM_144672.3:c.2302-736G>A,\N,\N,20/27,Benign,\N,intron_variant,1.612,0.0101,1KG_AMR_AF,OTOA
389839,16:21746867:A>G,NM_144672.3:c.2302-715A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,1.63,0.001,1KG_EUR_AF,OTOA
389840,16:21746906:C>A,NM_144672.3:c.2302-676C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,2.269,\N,\N,OTOA
389841,16:21746913:A>T,NM_144672.3:c.2302-669A>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.023,\N,\N,OTOA
389842,16:21746938:G>A,NM_144672.3:c.2302-644G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,2.13,0.0008,1KG_AFR_AF,OTOA
389843,16:21746943:G>T,NM_144672.3:c.2302-639G>T,\N,\N,20/27,Benign,\N,intron_variant,0.497,0.4871,1KG_EAS_AF,OTOA
389844,16:21746970:A>C,NM_144672.3:c.2302-612A>C,\N,\N,20/27,Unknown significance,\N,intron_variant,3.737,\N,\N,OTOA
389845,16:21747002:C>T,NM_144672.3:c.2302-580C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,2.722,0.0008,1KG_AFR_AF,OTOA
389846,16:21747005:C>T,NM_144672.3:c.2302-577C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,3.28,0.0015,1KG_AFR_AF,OTOA
389847,16:21747013:C>T,NM_144672.3:c.2302-569C>T,\N,\N,20/27,Benign,\N,intron_variant,1.867,0.0091,1KG_AFR_AF,OTOA
389848,16:21747014:T>G,NM_144672.3:c.2302-568T>G,\N,\N,20/27,Unknown significance,\N,intron_variant,0.299,0.0008,1KG_AFR_AF,OTOA
389849,16:21747027:G>C,NM_144672.3:c.2302-555G>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.408,0.0014,1KG_AMR_AF,OTOA
389850,16:21747073:A>C,NM_144672.3:c.2302-509A>C,\N,\N,20/27,Unknown significance,\N,intron_variant,0.082,\N,\N,OTOA
389851,16:21747077:A>G,NM_144672.3:c.2302-505A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,1.946,\N,\N,OTOA
389852,16:21747085:T>C,NM_144672.3:c.2302-497T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,1.329,\N,\N,OTOA
389853,16:21747098:A>G,NM_144672.3:c.2302-484A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,0.331,\N,\N,OTOA
389854,16:21747107:G>A,NM_144672.3:c.2302-475G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,1.761,0.002,1KG_SAS_AF,OTOA
389855,16:21747118:T>C,NM_144672.3:c.2302-464T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,1.369,\N,\N,OTOA
389856,16:21747164:C>A,NM_144672.3:c.2302-418C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,5.151,\N,\N,OTOA
389857,16:21747211:C>G,NM_144672.3:c.2302-371C>G,\N,\N,20/27,Unknown significance,\N,intron_variant,0.806,\N,\N,OTOA
389858,16:21747223:A>G,NM_144672.3:c.2302-359A>G,\N,\N,20/27,Benign,\N,intron_variant,0.894,0.3108,1KG_SAS_AF,OTOA
389859,16:21747232:C>G,NM_144672.3:c.2302-350C>G,\N,\N,20/27,Unknown significance,\N,intron_variant,0.264,0.001,1KG_SAS_AF,OTOA
389860,16:21747267:T>C,NM_144672.3:c.2302-315T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,3.148,\N,\N,OTOA
389861,16:21747281:G>A,NM_144672.3:c.2302-301G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,5.503,0.001,1KG_SAS_AF,OTOA
389862,16:21747313:G>A,NM_144672.3:c.2302-269G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,3.997,0.001,1KG_SAS_AF,OTOA
389863,16:21747319:C>T,NM_144672.3:c.2302-263C>T,\N,\N,20/27,Unknown significance,\N,intron_variant,4.473,\N,\N,OTOA
389864,16:21747344:G>T,NM_144672.3:c.2302-238G>T,\N,\N,20/27,Unknown significance,\N,intron_variant,0.693,0.001,1KG_SAS_AF,OTOA
389865,16:21747501:G>A,NM_144672.3:c.2302-81G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,2.116,\N,\N,OTOA
389866,16:21747540:G>A,NM_144672.3:c.2302-42G>A,\N,\N,20/27,Unknown significance,\N,intron_variant,2.334,0.0000158902,EXAC_NFE_AF,OTOA
389867,16:21747540:GT>G,NM_144672.3:c.2302-38del,\N,\N,20/27,Unknown significance,\N,intron_variant,0.58,0.0001213,EXAC_EAS_AF,OTOA
389868,16:21747547:T>G,NM_144672.3:c.2302-35T>G,\N,\N,20/27,Unknown significance,\N,intron_variant,6.147,\N,\N,OTOA
389869,16:21747552:A>C,NM_144672.3:c.2302-30A>C,\N,\N,20/27,Benign,\N,intron_variant,0.343,0.00625,OTO_CO_AF,OTOA
389870,16:21747555:C>A,NM_144672.3:c.2302-27C>A,\N,\N,20/27,Unknown significance,\N,intron_variant,4.536,\N,\N,OTOA
389871,16:21747556:C>G,NM_144672.3:c.2302-26C>G,\N,\N,20/27,Unknown significance,\N,intron_variant,0.237,\N,\N,OTOA
389872,16:21747556:C>T,NM_144672.3:c.2302-26C>T,\N,\N,20/27,Benign,\N,intron_variant,0.548,1,OTO_CO_AF,OTOA
389873,16:21747560:T>C,NM_144672.3:c.2302-22T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,3.406,\N,\N,OTOA
389874,16:21747566:A>G,NM_144672.3:c.2302-16A>G,\N,\N,20/27,Unknown significance,\N,intron_variant,1.92,0.003125,OTO_US_AF,OTOA
389875,16:21747570:T>C,NM_144672.3:c.2302-12T>C,\N,\N,20/27,Unknown significance,\N,intron_variant,1.082,0.0000606428,EXAC_SAS_AF,OTOA
389876,16:21747574:TCA>T,NM_144672.3:c.2302-3_2302-2del,\N,\N,20/27,Unknown significance,\N,splice_region_variant&intron_variant,5.559,0.000121242,EXAC_SAS_AF,OTOA
389877,16:21747576:A>G,NM_144672.3:c.2302-6A>G,\N,\N,20/27,Unknown significance,\N,splice_region_variant&intron_variant,0.522,0.001,1KG_EUR_AF,OTOA
389878,16:21747577:C>T,NM_144672.3:c.2302-5C>T,\N,\N,20/27,Unknown significance,\N,splice_region_variant&intron_variant,2.106,0.00011636,EVS_EA_AF,OTOA
389879,16:21747585:C>T,NM_144672.3:c.2305C>T,NP_653273.3:p.Pro769Ser,21/28,\N,Unknown significance,\N,missense_variant,23.2,0.0000150498,EXAC_NFE_AF,OTOA
389880,16:21747587:T>C,NM_144672.3:c.2307T>C,NP_653273.3:p.Pro769=,21/28,\N,Unknown significance,\N,synonymous_variant,0.067,\N,\N,OTOA
389881,16:21747606:G>A,NM_144672.3:c.2326G>A,NP_653273.3:p.Ala776Thr,21/28,\N,Unknown significance,\N,missense_variant,22.8,\N,\N,OTOA
389882,16:21747608:T>G,NM_144672.3:c.2328T>G,NP_653273.3:p.Ala776=,21/28,\N,Unknown significance,\N,synonymous_variant,1.272,0.000116279,EVS_EA_AF,OTOA
389883,16:21747612:A>C,NM_144672.3:c.2332A>C,NP_653273.3:p.Lys778Gln,21/28,\N,Likely benign,\N,missense_variant,0.023,0.000231107,EXAC_EAS_AF,OTOA
389884,16:21747614:G>A,NM_144672.3:c.2334G>A,NP_653273.3:p.Lys778=,21/28,\N,Unknown significance,\N,synonymous_variant,5.159,0.0008,1KG_AFR_AF,OTOA
389885,16:21747631:C>T,NM_144672.3:c.2351C>T,NP_653273.3:p.Pro784Leu,21/28,\N,Likely benign,\N,missense_variant,6.715,0.0000864454,EXAC_AMR_AF,OTOA
389886,16:21747632:CA>C,NM_144672.3:c.2353del,NP_653273.3:p.Thr785LeufsTer80,21/28,\N,Unknown significance,\N,frameshift_variant,25.4,0.000115554,EXAC_EAS_AF,OTOA
389887,16:21747633:A>C,NM_144672.3:c.2353A>C,NP_653273.3:p.Thr785Pro,21/28,\N,Benign,\N,missense_variant,0.003,0.0425,OTO_JP_AF,OTOA
389888,16:21747633:A>G,NM_144672.3:c.2353A>G,NP_653273.3:p.Thr785Ala,21/28,\N,Likely benign,\N,missense_variant,2.092,\N,\N,OTOA
389889,16:21747639:G>T,NM_144672.3:c.2359G>T,NP_653273.3:p.Glu787Ter,21/28,\N,Unknown significance,\N,stop_gained,38,\N,\N,OTOA
389890,16:21747644:C>A,NM_144672.3:c.2364C>A,NP_653273.3:p.Phe788Leu,21/28,\N,Likely benign,\N,missense_variant,13.11,0.000115554,EXAC_EAS_AF,OTOA
389891,16:21747644:C>T,NM_144672.3:c.2364C>T,NP_653273.3:p.Phe788=,21/28,\N,Unknown significance,\N,synonymous_variant,9.095,0.00022748,EVS_AA_AF,OTOA
389892,16:21747651:G>A,NM_144672.3:c.2371G>A,NP_653273.3:p.Ala791Thr,21/28,\N,Likely benign,\N,missense_variant,10.56,0.000115554,EXAC_EAS_AF,OTOA
389893,16:21747657:T>A,NM_144672.3:c.2377T>A,NP_653273.3:p.Phe793Ile,21/28,\N,Unknown significance,\N,missense_variant,24.7,\N,\N,OTOA
389894,16:21747662:G>A,NM_144672.3:c.2382G>A,NP_653273.3:p.Gln794=,21/28,\N,Benign,\N,synonymous_variant,0.043,0.215929,EXAC_EAS_AF,OTOA
389895,16:21747662:G>C,NM_001161683.1:c.2145G>C,NP_001155155.1:p.Gln715His,17/24,\N,Likely benign,\N,missense_variant,1.022,0.0000609459,EXAC_SAS_AF,OTOA
389896,16:21747665:T>C,NM_144672.3:c.2385T>C,NP_653273.3:p.Ser795=,21/28,\N,Unknown significance,\N,synonymous_variant,0.057,0.0008,1KG_AFR_AF,OTOA
389897,16:21747669:C>T,NM_144672.3:c.2389C>T,NP_653273.3:p.Arg797Trp,21/28,\N,Likely benign,\N,missense_variant,20.3,0.000192234,EXAC_AFR_AF,OTOA
389898,16:21747676:G>A,NM_144672.3:c.2396G>A,NP_653273.3:p.Ser799Asn,21/28,\N,Likely benign,\N,missense_variant,10.48,0.000060562,EXAC_SAS_AF,OTOA
389899,16:21747684:A>G,NM_144672.3:c.2404A>G,NP_653273.3:p.Lys802Glu,21/28,\N,Likely benign,\N,missense_variant,0.001,0.001,1KG_EAS_AF,OTOA
389900,16:21747688:T>A,NM_144672.3:c.2408T>A,NP_653273.3:p.Ile803Asn,21/28,\N,Likely benign,\N,missense_variant,0.015,0.0000449586,EXAC_NFE_AF,OTOA
389901,16:21747690:C>G,NM_144672.3:c.2410C>G,NP_653273.3:p.Pro804Ala,21/28,\N,Likely benign,\N,missense_variant,0.035,\N,\N,OTOA
389902,16:21747691:C>T,NM_144672.3:c.2411C>T,NP_653273.3:p.Pro804Leu,21/28,\N,Likely benign,\N,missense_variant,5.83,0.00022748,EVS_AA_AF,OTOA
389903,16:21747697:A>C,NM_144672.3:c.2417A>C,NP_653273.3:p.Tyr806Ser,21/28,\N,Likely benign,\N,missense_variant,0.143,0.00318471,EVS_AA_AF,OTOA
389904,16:21747697:A>G,NM_144672.3:c.2417A>G,NP_653273.3:p.Tyr806Cys,21/28,\N,Likely benign,\N,missense_variant,1.849,\N,\N,OTOA
389905,16:21747701:C>T,NM_144672.3:c.2421C>T,NP_653273.3:p.Asp807=,21/28,\N,Unknown significance,\N,synonymous_variant,3.34,0.000116279,EVS_EA_AF,OTOA
389906,16:21747702:C>T,NM_144672.3:c.2422C>T,NP_653273.3:p.Pro808Ser,21/28,\N,Likely benign,\N,missense_variant,0.004,0.0000149871,EXAC_NFE_AF,OTOA
389907,16:21747703:C>G,NM_144672.3:c.2423C>G,NP_653273.3:p.Pro808Arg,21/28,\N,Likely benign,\N,missense_variant,0.05,0.0000149871,EXAC_NFE_AF,OTOA
389908,16:21747703:C>T,NM_144672.3:c.2423C>T,NP_653273.3:p.Pro808Leu,21/28,\N,Likely benign,\N,missense_variant,4.426,0.0000149871,EXAC_NFE_AF,OTOA
389909,16:21747705:A>G,NM_144672.3:c.2425A>G,NP_653273.3:p.Met809Val,21/28,\N,Likely benign,\N,missense_variant,0.002,0.000060562,EXAC_SAS_AF,OTOA
389910,16:21747713:T>C,NM_144672.3:c.2431+2T>C,\N,\N,21/27,Unknown significance,\N,splice_donor_variant,20.7,0.000151194,EXAC_FIN_AF,OTOA
389911,16:21747719:T>C,NM_144672.3:c.2431+8T>C,\N,\N,21/27,Unknown significance,\N,splice_region_variant&intron_variant,1.094,\N,\N,OTOA
389912,16:21747722:T>C,NM_144672.3:c.2431+11T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,4.239,0.00201923,EXAC_AFR_AF,OTOA
389913,16:21747726:G>T,NM_144672.3:c.2431+15G>T,\N,\N,21/27,Unknown significance,\N,intron_variant,1.858,0.0000149903,EXAC_NFE_AF,OTOA
389914,16:21747734:A>G,NM_144672.3:c.2431+23A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,3.521,0.0000864304,EXAC_AMR_AF,OTOA
389915,16:21747738:A>G,NM_144672.3:c.2431+27A>G,\N,\N,21/27,Benign,\N,intron_variant,0.228,0.225,OTO_TR_AF,OTOA
389916,16:21747739:T>C,NM_144672.3:c.2431+28T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,0.42,0.000121183,EXAC_SAS_AF,OTOA
389917,16:21747739:T>G,NM_144672.3:c.2431+28T>G,\N,\N,21/27,Unknown significance,\N,intron_variant,0.775,0.0000149939,EXAC_NFE_AF,OTOA
389918,16:21747742:C>T,NM_144672.3:c.2431+31C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,2.324,\N,\N,OTOA
389919,16:21747745:A>G,NM_144672.3:c.2431+34A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,3.453,\N,\N,OTOA
389920,16:21747750:G>A,NM_144672.3:c.2431+39G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,3.788,\N,\N,OTOA
389921,16:21747763:T>TG,NM_144672.3:c.2431+55dup,\N,\N,21/27,Unknown significance,\N,intron_variant,1.979,\N,\N,OTOA
389922,16:21747766:G>A,NM_144672.3:c.2431+55G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,2.16,\N,\N,OTOA
389923,16:21747777:G>A,NM_144672.3:c.2431+66G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,1.763,\N,\N,OTOA
389924,16:21747881:G>A,NM_144672.3:c.2431+170G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,1.913,\N,\N,OTOA
389925,16:21747882:T>G,NM_144672.3:c.2431+171T>G,\N,\N,21/27,Unknown significance,\N,intron_variant,4.433,\N,\N,OTOA
389926,16:21747961:G>A,NM_144672.3:c.2431+250G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,4.917,0.002,1KG_SAS_AF,OTOA
389927,16:21747966:A>G,NM_144672.3:c.2431+255A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,5.623,\N,\N,OTOA
389928,16:21747978:C>G,NM_144672.3:c.2431+267C>G,\N,\N,21/27,Unknown significance,\N,intron_variant,1.446,0.0029,1KG_AMR_AF,OTOA
389929,16:21747991:G>A,NM_144672.3:c.2431+280G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,2.002,\N,\N,OTOA
389930,16:21748008:C>T,NM_144672.3:c.2431+297C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,1.822,0.001,1KG_EAS_AF,OTOA
389931,16:21748024:T>C,NM_144672.3:c.2431+313T>C,\N,\N,21/27,Benign,\N,intron_variant,0.021,0.3108,1KG_SAS_AF,OTOA
389932,16:21748035:T>C,NM_144672.3:c.2431+324T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,0.249,\N,\N,OTOA
389933,16:21748106:G>A,NM_144672.3:c.2431+395G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,2.241,\N,\N,OTOA
389934,16:21748137:G>A,NM_144672.3:c.2431+426G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,0.312,0.001,1KG_EUR_AF,OTOA
389935,16:21748145:G>C,NM_144672.3:c.2431+434G>C,\N,\N,21/27,Unknown significance,\N,intron_variant,1.585,0.003,1KG_AFR_AF,OTOA
389936,16:21748149:C>CA,NM_144672.3:c.2431+448dup,\N,\N,21/27,Unknown significance,\N,intron_variant,6.517,\N,\N,OTOA
389937,16:21748187:A>T,NM_144672.3:c.2431+476A>T,\N,\N,21/27,Unknown significance,\N,intron_variant,10.03,\N,\N,OTOA
389938,16:21748230:G>A,NM_144672.3:c.2431+519G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,3.484,0.0023,1KG_AFR_AF,OTOA
389939,16:21748271:G>A,NM_144672.3:c.2431+560G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,9.421,0.001,1KG_EUR_AF,OTOA
389940,16:21748298:T>G,NM_144672.3:c.2431+587T>G,\N,\N,21/27,Benign,\N,intron_variant,3.156,0.0133,1KG_SAS_AF,OTOA
389941,16:21748313:C>T,NM_144672.3:c.2431+602C>T,\N,\N,21/27,Benign,\N,intron_variant,0.793,0.0098,1KG_AFR_AF,OTOA
389942,16:21748314:G>A,NM_144672.3:c.2431+603G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,1.443,0.001,1KG_SAS_AF,OTOA
389943,16:21748324:C>G,NM_144672.3:c.2431+613C>G,\N,\N,21/27,Unknown significance,\N,intron_variant,2.214,\N,\N,OTOA
389944,16:21748326:T>G,NM_144672.3:c.2431+615T>G,\N,\N,21/27,Benign,\N,intron_variant,2.844,0.0189,1KG_EUR_AF,OTOA
389945,16:21748349:A>T,NM_144672.3:c.2431+638A>T,\N,\N,21/27,Benign,\N,intron_variant,5.968,0.0061,1KG_SAS_AF,OTOA
389946,16:21748386:G>GT,NM_144672.3:c.2431+676dup,\N,\N,21/27,Unknown significance,\N,intron_variant,9.749,\N,\N,OTOA
389947,16:21748466:T>A,NM_144672.3:c.2431+755T>A,\N,\N,21/27,Unknown significance,\N,intron_variant,9.319,\N,\N,OTOA
389948,16:21748523:T>C,NM_144672.3:c.2431+812T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,2.215,0.001,1KG_EUR_AF,OTOA
389949,16:21748529:A>G,NM_144672.3:c.2431+818A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,0.988,0.0008,1KG_AFR_AF,OTOA
389950,16:21748625:A>C,NM_144672.3:c.2431+914A>C,\N,\N,21/27,Unknown significance,\N,intron_variant,1.708,\N,\N,OTOA
389951,16:21748664:G>A,NM_144672.3:c.2431+953G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,8.35,0.004,1KG_EAS_AF,OTOA
389952,16:21748702:C>T,NM_144672.3:c.2431+991C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,0.783,0.0014,1KG_AMR_AF,OTOA
389953,16:21748703:G>A,NM_144672.3:c.2431+992G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,4.034,\N,\N,OTOA
389954,16:21748734:C>T,NM_144672.3:c.2431+1023C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,0.26,0.0029,1KG_AMR_AF,OTOA
389955,16:21748737:G>A,NM_144672.3:c.2431+1026G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,2.606,0.003,1KG_EAS_AF,OTOA
389956,16:21748825:G>A,NM_144672.3:c.2431+1114G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,1.127,\N,\N,OTOA
389957,16:21748880:A>G,NM_144672.3:c.2431+1169A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,3.453,\N,\N,OTOA
389958,16:21748899:A>AGTGGT,NM_144672.3:c.2431+1189_2431+1190insTGGTG,\N,\N,21/27,Unknown significance,\N,intron_variant,2.426,\N,\N,OTOA
389959,16:21748914:C>T,NM_144672.3:c.2431+1203C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,8.124,\N,\N,OTOA
389960,16:21748923:C>T,NM_144672.3:c.2431+1212C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,9.612,\N,\N,OTOA
389961,16:21748941:G>A,NM_144672.3:c.2431+1230G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,6.179,\N,\N,OTOA
389962,16:21748947:T>G,NM_144672.3:c.2431+1236T>G,\N,\N,21/27,Unknown significance,\N,intron_variant,9.218,0.0008,1KG_AFR_AF,OTOA
389963,16:21748987:A>C,NM_144672.3:c.2431+1276A>C,\N,\N,21/27,Unknown significance,\N,intron_variant,1.55,\N,\N,OTOA
389964,16:21749005:A>C,NM_144672.3:c.2431+1294A>C,\N,\N,21/27,Unknown significance,\N,intron_variant,1.665,\N,\N,OTOA
389965,16:21749012:A>AT,NM_144672.3:c.2431+1308dup,\N,\N,21/27,Unknown significance,\N,intron_variant,0.193,\N,\N,OTOA
389966,16:21749036:A>G,NM_144672.3:c.2431+1325A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,1.629,\N,\N,OTOA
389967,16:21749118:T>C,NM_144672.3:c.2431+1407T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,10.55,\N,\N,OTOA
389968,16:21749121:G>A,NM_144672.3:c.2431+1410G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,10.6,0.0023,1KG_AFR_AF,OTOA
389969,16:21749142:T>C,NM_144672.3:c.2431+1431T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,9.841,0.0014,1KG_AMR_AF,OTOA
389970,16:21749160:T>C,NM_144672.3:c.2431+1449T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,3.474,\N,\N,OTOA
389971,16:21749169:G>A,NM_144672.3:c.2431+1458G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,1.569,0.0008,1KG_AFR_AF,OTOA
389972,16:21749220:C>G,NM_144672.3:c.2431+1509C>G,\N,\N,21/27,Benign,\N,intron_variant,1.147,0.2986,1KG_EAS_AF,OTOA
389973,16:21749221:C>A,NM_144672.3:c.2431+1510C>A,\N,\N,21/27,Benign,\N,intron_variant,2.096,0.2986,1KG_EAS_AF,OTOA
389974,16:21749226:G>A,NM_144672.3:c.2431+1515G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,3.66,\N,\N,OTOA
389975,16:21749265:C>T,NM_144672.3:c.2431+1554C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,6.807,0.0014,1KG_AMR_AF,OTOA
389976,16:21749293:G>A,NM_144672.3:c.2431+1582G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,1.586,0.003,1KG_EAS_AF,OTOA
389977,16:21749368:A>T,NM_144672.3:c.2431+1657A>T,\N,\N,21/27,Unknown significance,\N,intron_variant,0.157,0.001,1KG_EUR_AF,OTOA
389978,16:21749417:G>A,NM_144672.3:c.2431+1706G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,0.615,0.0008,1KG_AFR_AF,OTOA
389979,16:21749455:T>C,NM_144672.3:c.2431+1744T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,0.91,\N,\N,OTOA
389980,16:21749464:A>G,NM_144672.3:c.2431+1753A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,1.45,\N,\N,OTOA
389981,16:21749555:A>G,NM_144672.3:c.2431+1844A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,2.396,\N,\N,OTOA
389982,16:21749562:C>T,NM_144672.3:c.2431+1851C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,0.635,\N,\N,OTOA
389983,16:21749566:T>C,NM_144672.3:c.2431+1855T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,1.072,\N,\N,OTOA
389984,16:21749575:T>C,NM_144672.3:c.2431+1864T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,1.212,0.0041,1KG_SAS_AF,OTOA
389985,16:21749632:T>C,NM_144672.3:c.2431+1921T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,0.094,\N,\N,OTOA
389986,16:21749643:G>A,NM_144672.3:c.2431+1932G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,3.63,\N,\N,OTOA
389987,16:21749686:G>A,NM_144672.3:c.2431+1975G>A,\N,\N,21/27,Benign,\N,intron_variant,0.249,0.2093,1KG_EAS_AF,OTOA
389988,16:21749686:G>C,NM_144672.3:c.2431+1975G>C,\N,\N,21/27,Unknown significance,\N,intron_variant,0.041,\N,\N,OTOA
389989,16:21749686:G>T,NM_144672.3:c.2431+1975G>T,\N,\N,21/27,Unknown significance,\N,intron_variant,0.091,\N,\N,OTOA
389990,16:21749723:G>A,NM_144672.3:c.2431+2012G>A,\N,\N,21/27,Benign,\N,intron_variant,1.572,0.3393,1KG_EAS_AF,OTOA
389991,16:21749769:C>T,NM_144672.3:c.2431+2058C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,7.631,0.0008,1KG_AFR_AF,OTOA
389992,16:21749770:G>A,NM_144672.3:c.2431+2059G>A,\N,\N,21/27,Benign,\N,intron_variant,6.42,0.3415,1KG_AMR_AF,OTOA
389993,16:21749771:T>TTTTG,NM_144672.3:c.2431+2063_2431+2064insGTTT,\N,\N,21/27,Unknown significance,\N,intron_variant,6.057,\N,\N,OTOA
389994,16:21749772:T>TTTG,NM_144672.3:c.2431+2063_2431+2064insGTT,\N,\N,21/27,Benign,\N,intron_variant,7.457,0.3415,1KG_AMR_AF,OTOA
389995,16:21749772:T>TTTGC,NM_144672.3:c.2431+2063_2431+2064insGCTT,\N,\N,21/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
389996,16:21749777:T>C,NM_144672.3:c.2431+2066T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,4.214,0.001,1KG_EAS_AF,OTOA
389997,16:21749873:C>T,NM_144672.3:c.2431+2162C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,8.055,\N,\N,OTOA
389998,16:21749897:G>A,NM_144672.3:c.2432-2145G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,0.402,\N,\N,OTOA
389999,16:21749950:T>C,NM_144672.3:c.2432-2092T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,0.191,\N,\N,OTOA
390000,16:21749961:C>A,NM_144672.3:c.2432-2081C>A,\N,\N,21/27,Unknown significance,\N,intron_variant,7.963,\N,\N,OTOA
390001,16:21749966:A>G,NM_144672.3:c.2432-2076A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,9.471,\N,\N,OTOA
390002,16:21749967:T>C,NM_144672.3:c.2432-2075T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,9.028,0.0014,1KG_AMR_AF,OTOA
390003,16:21749972:C>T,NM_144672.3:c.2432-2070C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,10.21,\N,\N,OTOA
390004,16:21750058:G>T,NM_144672.3:c.2432-1984G>T,\N,\N,21/27,Unknown significance,\N,intron_variant,0.958,0,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,OTOA
390005,16:21750072:G>A,NM_144672.3:c.2432-1970G>A,\N,\N,21/27,Benign,\N,intron_variant,3.379,0.0397,1KG_EAS_AF,OTOA
390006,16:21750096:C>T,NM_144672.3:c.2432-1946C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,0.153,\N,\N,OTOA
390007,16:21750101:A>C,NM_144672.3:c.2432-1941A>C,\N,\N,21/27,Unknown significance,\N,intron_variant,0.632,0.0008,1KG_AFR_AF,OTOA
390008,16:21750122:T>C,NM_144672.3:c.2432-1920T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,1.494,0.001,1KG_EAS_AF,OTOA
390009,16:21750210:A>G,NM_144672.3:c.2432-1832A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,9.618,0.001,1KG_SAS_AF,OTOA
390010,16:21750249:C>T,NM_144672.3:c.2432-1793C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,4.475,\N,\N,OTOA
390011,16:21750255:T>C,NM_144672.3:c.2432-1787T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,1.919,\N,\N,OTOA
390012,16:21750351:A>AG,NM_144672.3:c.2432-1691_2432-1690insG,\N,\N,21/27,Benign,\N,intron_variant,0.042,0.2887,1KG_EAS_AF,OTOA
390013,16:21750371:G>A,NM_144672.3:c.2432-1671G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,1.434,\N,\N,OTOA
390014,16:21750410:C>T,NM_144672.3:c.2432-1632C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,3.053,0.001,1KG_EUR_AF,OTOA
390015,16:21750432:A>G,NM_144672.3:c.2432-1610A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,1.735,\N,\N,OTOA
390016,16:21750455:G>A,NM_144672.3:c.2432-1587G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,2.684,\N,\N,OTOA
390017,16:21750475:G>A,NM_144672.3:c.2432-1567G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,0.487,\N,\N,OTOA
390018,16:21750541:G>T,NM_144672.3:c.2432-1501G>T,\N,\N,21/27,Unknown significance,\N,intron_variant,4.343,\N,\N,OTOA
390019,16:21750671:T>C,NM_144672.3:c.2432-1371T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,2.584,0.0008,1KG_AFR_AF,OTOA
390020,16:21750866:G>A,NM_144672.3:c.2432-1176G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,2.324,\N,\N,OTOA
390021,16:21750913:A>G,NM_144672.3:c.2432-1129A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,5.528,0.001,1KG_EAS_AF,OTOA
390022,16:21750922:T>C,NM_144672.3:c.2432-1120T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,3.218,\N,\N,OTOA
390023,16:21751008:G>A,NM_144672.3:c.2432-1034G>A,\N,\N,21/27,Unknown significance,\N,intron_variant,5.35,\N,\N,OTOA
390024,16:21751085:A>G,NM_144672.3:c.2432-957A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,0.796,\N,\N,OTOA
390025,16:21751462:C>T,NM_144672.3:c.2432-580C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,0.178,\N,\N,OTOA
390026,16:21751527:C>T,NM_144672.3:c.2432-515C>T,\N,\N,21/27,Unknown significance,\N,intron_variant,5.192,\N,\N,OTOA
390027,16:21751814:T>C,NM_144672.3:c.2432-228T>C,\N,\N,21/27,Unknown significance,\N,intron_variant,16.45,\N,\N,OTOA
390028,16:21751903:C>G,NM_144672.3:c.2432-139C>G,\N,\N,21/27,Unknown significance,\N,intron_variant,1.401,\N,\N,OTOA
390029,16:21751958:A>G,NM_144672.3:c.2432-84A>G,\N,\N,21/27,Unknown significance,\N,intron_variant,1.652,\N,\N,OTOA
390030,16:21752383:C>T,NM_144672.3:c.2619+154C>T,\N,\N,22/27,Unknown significance,\N,intron_variant,10.42,\N,\N,OTOA
390031,16:21752490:C>T,NM_144672.3:c.2619+261C>T,\N,\N,22/27,Unknown significance,\N,intron_variant,4.202,\N,\N,OTOA
390032,16:21752671:G>T,NM_144672.3:c.2619+442G>T,\N,\N,22/27,Unknown significance,\N,intron_variant,1.88,\N,\N,OTOA
390033,16:21752746:G>A,NM_144672.3:c.2619+517G>A,\N,\N,22/27,Unknown significance,\N,intron_variant,0.808,\N,\N,OTOA
390034,16:21752761:C>T,NM_144672.3:c.2619+532C>T,\N,\N,22/27,Unknown significance,\N,intron_variant,0.556,\N,\N,OTOA
390035,16:21754127:C>A,NM_144672.3:c.2619+1898C>A,\N,\N,22/27,Unknown significance,\N,intron_variant,8.817,\N,\N,OTOA
390036,16:21754476:A>T,NM_144672.3:c.2620-1726A>T,\N,\N,22/27,Unknown significance,\N,intron_variant,0.898,\N,\N,OTOA
390037,16:21754663:A>G,NM_144672.3:c.2620-1539A>G,\N,\N,22/27,Benign,\N,intron_variant,2.355,0.0377,1KG_EAS_AF,OTOA
390038,16:21754693:G>A,NM_144672.3:c.2620-1509G>A,\N,\N,22/27,Unknown significance,\N,intron_variant,5.965,0.002,1KG_EUR_AF,OTOA
390039,16:21754792:C>T,NM_144672.3:c.2620-1410C>T,\N,\N,22/27,Unknown significance,\N,intron_variant,9.095,0.0015,1KG_AFR_AF,OTOA
390040,16:21754820:G>A,NM_144672.3:c.2620-1382G>A,\N,\N,22/27,Unknown significance,\N,intron_variant,0.772,0.001,1KG_SAS_AF,OTOA
390041,16:21754970:G>A,NM_144672.3:c.2620-1232G>A,\N,\N,22/27,Unknown significance,\N,intron_variant,1.354,0.001,1KG_EUR_AF,OTOA
390042,16:21755267:C>T,NM_144672.3:c.2620-935C>T,\N,\N,22/27,Unknown significance,\N,intron_variant,1.303,0.001,1KG_EAS_AF,OTOA
390043,16:21755303:T>C,NM_144672.3:c.2620-899T>C,\N,\N,22/27,Unknown significance,\N,intron_variant,0.065,0.0008,1KG_AFR_AF,OTOA
390044,16:21755412:A>G,NM_144672.3:c.2620-790A>G,\N,\N,22/27,Unknown significance,\N,intron_variant,0.687,\N,\N,OTOA
390045,16:21755424:A>G,NM_144672.3:c.2620-778A>G,\N,\N,22/27,Unknown significance,\N,intron_variant,2.001,0.001,1KG_EUR_AF,OTOA
390046,16:21755617:T>C,NM_144672.3:c.2620-585T>C,\N,\N,22/27,Benign,\N,intron_variant,0.464,0.0184,1KG_SAS_AF,OTOA
390047,16:21755658:G>A,NM_144672.3:c.2620-544G>A,\N,\N,22/27,Unknown significance,\N,intron_variant,0.076,\N,\N,OTOA
390048,16:21755672:T>C,NM_144672.3:c.2620-530T>C,\N,\N,22/27,Unknown significance,\N,intron_variant,2.441,0.001,1KG_EAS_AF|1KG_SAS_AF,OTOA
390049,16:21755703:T>C,NM_144672.3:c.2620-499T>C,\N,\N,22/27,Unknown significance,\N,intron_variant,0.354,\N,\N,OTOA
390050,16:21755813:A>G,NM_144672.3:c.2620-389A>G,\N,\N,22/27,Unknown significance,\N,intron_variant,1.445,0.0008,1KG_AFR_AF,OTOA
390051,16:21756416:T>C,NM_144672.3:c.2775+59T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,2.183,\N,\N,OTOA
390052,16:21757036:A>C,NM_144672.3:c.2775+679A>C,\N,\N,23/27,Unknown significance,\N,intron_variant,1.681,\N,\N,OTOA
390053,16:21757383:G>A,NM_144672.3:c.2775+1026G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,0.169,\N,\N,OTOA
390054,16:21757626:G>A,NM_144672.3:c.2775+1269G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,1.028,0.001,1KG_EAS_AF,OTOA
390055,16:21757663:G>C,NM_144672.3:c.2775+1306G>C,\N,\N,23/27,Unknown significance,\N,intron_variant,0.88,\N,\N,OTOA
390056,16:21757699:C>G,NM_144672.3:c.2775+1342C>G,\N,\N,23/27,Unknown significance,\N,intron_variant,0.17,\N,\N,OTOA
390057,16:21757979:T>C,NM_144672.3:c.2775+1622T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,2.135,\N,\N,OTOA
390058,16:21758036:A>G,NM_144672.3:c.2775+1679A>G,\N,\N,23/27,Unknown significance,\N,intron_variant,1.295,\N,\N,OTOA
390059,16:21758070:G>T,NM_144672.3:c.2775+1713G>T,\N,\N,23/27,Unknown significance,\N,intron_variant,0.699,\N,\N,OTOA
390060,16:21758125:G>A,NM_144672.3:c.2775+1768G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,2.16,\N,\N,OTOA
390061,16:21758196:T>C,NM_144672.3:c.2775+1839T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,1.62,0.0008,1KG_AFR_AF,OTOA
390062,16:21758213:C>T,NM_144672.3:c.2775+1856C>T,\N,\N,23/27,Unknown significance,\N,intron_variant,0.492,\N,\N,OTOA
390063,16:21758262:C>G,NM_144672.3:c.2775+1905C>G,\N,\N,23/27,Unknown significance,\N,intron_variant,2.456,\N,\N,OTOA
390064,16:21758389:T>TA,NM_144672.3:c.2775+2033dup,\N,\N,23/27,Unknown significance,\N,intron_variant,1.037,\N,\N,OTOA
390065,16:21758470:T>C,NM_144672.3:c.2775+2113T>C,\N,\N,23/27,Benign,\N,intron_variant,1.226,0.1607,1KG_EAS_AF,OTOA
390066,16:21758484:G>C,NM_144672.3:c.2775+2127G>C,\N,\N,23/27,Unknown significance,\N,intron_variant,7.651,\N,\N,OTOA
390067,16:21758512:C>A,NM_144672.3:c.2775+2155C>A,\N,\N,23/27,Unknown significance,\N,intron_variant,1.76,0.001,1KG_EAS_AF,OTOA
390068,16:21758616:C>T,NM_144672.3:c.2775+2259C>T,\N,\N,23/27,Unknown significance,\N,intron_variant,16.77,\N,\N,OTOA
390069,16:21758619:G>C,NM_144672.3:c.2775+2262G>C,\N,\N,23/27,Benign,\N,intron_variant,3.98,0.0061,1KG_SAS_AF,OTOA
390070,16:21758619:G>T,NM_144672.3:c.2775+2262G>T,\N,\N,23/27,Unknown significance,\N,intron_variant,5.158,\N,\N,OTOA
390071,16:21758622:C>T,NM_144672.3:c.2775+2265C>T,\N,\N,23/27,Unknown significance,\N,intron_variant,8.206,\N,\N,OTOA
390072,16:21758623:G>A,NM_144672.3:c.2775+2266G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,8.816,0.002,1KG_EUR_AF,OTOA
390073,16:21758643:G>C,NM_144672.3:c.2775+2286G>C,\N,\N,23/27,Unknown significance,\N,intron_variant,5.058,\N,\N,OTOA
390074,16:21758671:G>A,NM_144672.3:c.2775+2314G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,8.815,0.0008,1KG_AFR_AF,OTOA
390075,16:21758675:C>T,NM_144672.3:c.2775+2318C>T,\N,\N,23/27,Unknown significance,\N,intron_variant,10.39,0.001,1KG_EAS_AF,OTOA
390076,16:21758696:G>A,NM_144672.3:c.2775+2339G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,18.9,\N,\N,OTOA
390077,16:21758703:G>A,NM_144672.3:c.2775+2346G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,19.04,0.004,1KG_EUR_AF,OTOA
390078,16:21758780:G>C,NM_144672.3:c.2775+2423G>C,\N,\N,23/27,Unknown significance,\N,intron_variant,16.03,0.001,1KG_SAS_AF,OTOA
390079,16:21758803:G>T,NM_144672.3:c.2775+2446G>T,\N,\N,23/27,Unknown significance,\N,intron_variant,14.97,\N,\N,OTOA
390080,16:21759050:T>G,NM_144672.3:c.2775+2693T>G,\N,\N,23/27,Unknown significance,\N,intron_variant,19.62,\N,\N,OTOA
390081,16:21759114:T>C,NM_144672.3:c.2775+2757T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,17.48,\N,\N,OTOA
390082,16:21759209:A>G,NM_144672.3:c.2775+2852A>G,\N,\N,23/27,Benign,\N,intron_variant,6.606,0.1974,1KG_EAS_AF,OTOA
390083,16:21759230:T>A,NM_144672.3:c.2775+2873T>A,\N,\N,23/27,Unknown significance,\N,intron_variant,7.581,0.003,1KG_AFR_AF,OTOA
390084,16:21759255:C>T,NM_144672.3:c.2775+2898C>T,\N,\N,23/27,Benign,\N,intron_variant,14.3,0.1746,1KG_EAS_AF,OTOA
390085,16:21759295:G>A,NM_144672.3:c.2775+2938G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,2.236,\N,\N,OTOA
390086,16:21759481:A>G,NM_144672.3:c.2775+3124A>G,\N,\N,23/27,Unknown significance,\N,intron_variant,2.079,\N,\N,OTOA
390087,16:21759757:T>G,NM_144672.3:c.2775+3400T>G,\N,\N,23/27,Unknown significance,\N,intron_variant,1.076,\N,\N,OTOA
390088,16:21759920:T>C,NM_144672.3:c.2776-3336T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,1.6,\N,\N,OTOA
390089,16:21760015:G>C,NM_144672.3:c.2776-3241G>C,\N,\N,23/27,Unknown significance,\N,intron_variant,1.558,\N,\N,OTOA
390090,16:21760061:G>A,NM_144672.3:c.2776-3195G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,4.539,0.001,1KG_EUR_AF,OTOA
390091,16:21760107:C>T,NM_144672.3:c.2776-3149C>T,\N,\N,23/27,Unknown significance,\N,intron_variant,3.798,0.001,1KG_EUR_AF,OTOA
390092,16:21760204:G>A,NM_144672.3:c.2776-3052G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,13.85,0.001,1KG_EUR_AF,OTOA
390093,16:21760315:C>T,NM_144672.3:c.2776-2941C>T,\N,\N,23/27,Unknown significance,\N,intron_variant,1.485,\N,\N,OTOA
390094,16:21760539:G>T,NM_144672.3:c.2776-2717G>T,\N,\N,23/27,Unknown significance,\N,intron_variant,1.206,0.001,1KG_SAS_AF,OTOA
390095,16:21760566:G>A,NM_144672.3:c.2776-2690G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,0.308,0.003,1KG_EAS_AF,OTOA
390096,16:21760568:T>C,NM_144672.3:c.2776-2688T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,0.967,\N,\N,OTOA
390097,16:21760589:T>C,NM_144672.3:c.2776-2667T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,3.295,\N,\N,OTOA
390098,16:21760613:T>C,NM_144672.3:c.2776-2643T>C,\N,\N,23/27,Benign,\N,intron_variant,4.485,0.0389,1KG_SAS_AF,OTOA
390099,16:21760676:T>C,NM_144672.3:c.2776-2580T>C,\N,\N,23/27,Benign,\N,intron_variant,2.607,0.0348,1KG_SAS_AF,OTOA
390100,16:21760849:C>CA,NM_144672.3:c.2776-2395dup,\N,\N,23/27,Benign,\N,intron_variant,2.866,0.1339,1KG_AFR_AF,OTOA
390101,16:21760861:A>C,NM_144672.3:c.2776-2395A>C,\N,\N,23/27,Unknown significance,\N,intron_variant,0.515,0.001,1KG_SAS_AF,OTOA
390102,16:21761281:C>A,NM_144672.3:c.2776-1975C>A,\N,\N,23/27,Unknown significance,\N,intron_variant,4.052,0.001,1KG_SAS_AF,OTOA
390103,16:21761283:G>C,NM_144672.3:c.2776-1973G>C,\N,\N,23/27,Unknown significance,\N,intron_variant,0.967,0.0008,1KG_AFR_AF,OTOA
390104,16:21761382:A>C,NM_144672.3:c.2776-1874A>C,\N,\N,23/27,Unknown significance,\N,intron_variant,2.85,0.001,1KG_SAS_AF,OTOA
390105,16:21761458:C>G,NM_144672.3:c.2776-1798C>G,\N,\N,23/27,Unknown significance,\N,intron_variant,0.638,\N,\N,OTOA
390106,16:21761472:A>C,NM_144672.3:c.2776-1784A>C,\N,\N,23/27,Unknown significance,\N,intron_variant,1.691,\N,\N,OTOA
390107,16:21761480:A>T,NM_144672.3:c.2776-1776A>T,\N,\N,23/27,Unknown significance,\N,intron_variant,0.933,\N,\N,OTOA
390108,16:21761498:G>T,NM_144672.3:c.2776-1758G>T,\N,\N,23/27,Unknown significance,\N,intron_variant,0.821,0.0023,1KG_AFR_AF,OTOA
390109,16:21761504:A>G,NM_144672.3:c.2776-1752A>G,\N,\N,23/27,Unknown significance,\N,intron_variant,2.888,\N,\N,OTOA
390110,16:21761506:C>T,NM_144672.3:c.2776-1750C>T,\N,\N,23/27,Unknown significance,\N,intron_variant,0.486,\N,\N,OTOA
390111,16:21761586:C>T,NM_144672.3:c.2776-1670C>T,\N,\N,23/27,Unknown significance,\N,intron_variant,2.521,\N,\N,OTOA
390112,16:21761642:G>A,NM_144672.3:c.2776-1614G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,3.604,\N,\N,OTOA
390113,16:21761665:G>A,NM_144672.3:c.2776-1591G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,0.571,\N,\N,OTOA
390114,16:21761674:T>C,NM_144672.3:c.2776-1582T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,2.177,\N,\N,OTOA
390115,16:21761709:G>A,NM_144672.3:c.2776-1547G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,1.881,0.0008,1KG_AFR_AF,OTOA
390116,16:21761733:C>CAAAAAA,NM_144672.3:c.2776-1509_2776-1504dup,\N,\N,23/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
390117,16:21761831:G>A,NM_144672.3:c.2776-1425G>A,\N,\N,23/27,Benign,\N,intron_variant,0.079,0.0337,1KG_SAS_AF,OTOA
390118,16:21761864:C>G,NM_144672.3:c.2776-1392C>G,\N,\N,23/27,Unknown significance,\N,intron_variant,2.372,\N,\N,OTOA
390119,16:21761904:C>G,NM_144672.3:c.2776-1352C>G,\N,\N,23/27,Unknown significance,\N,intron_variant,2.079,\N,\N,OTOA
390120,16:21762732:G>A,NM_144672.3:c.2776-524G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,6.996,0.001,1KG_EAS_AF,OTOA
390121,16:21762750:G>T,NM_144672.3:c.2776-506G>T,\N,\N,23/27,Benign,\N,intron_variant,1.296,0.0575,1KG_EAS_AF,OTOA
390122,16:21762785:T>C,NM_144672.3:c.2776-471T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,4.309,\N,\N,OTOA
390123,16:21762874:A>G,NM_144672.3:c.2776-382A>G,\N,\N,23/27,Unknown significance,\N,intron_variant,1.485,0.0008,1KG_AFR_AF,OTOA
390124,16:21762887:A>G,NM_144672.3:c.2776-369A>G,\N,\N,23/27,Unknown significance,\N,intron_variant,3.149,0.001,1KG_SAS_AF,OTOA
390125,16:21762929:T>C,NM_144672.3:c.2776-327T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,3.987,0.0008,1KG_AFR_AF,OTOA
390126,16:21763032:A>G,NM_144672.3:c.2776-224A>G,\N,\N,23/27,Unknown significance,\N,intron_variant,1.563,\N,\N,OTOA
390127,16:21763045:A>G,NM_144672.3:c.2776-211A>G,\N,\N,23/27,Unknown significance,\N,intron_variant,3.034,0.0029,1KG_AMR_AF,OTOA
390128,16:21763049:T>C,NM_144672.3:c.2776-207T>C,\N,\N,23/27,Unknown significance,\N,intron_variant,1.221,\N,\N,OTOA
390129,16:21763090:G>A,NM_144672.3:c.2776-166G>A,\N,\N,23/27,Unknown significance,\N,intron_variant,7.303,0.003,1KG_EAS_AF,OTOA
390130,16:21763095:T>A,NM_144672.3:c.2776-161T>A,\N,\N,23/27,Unknown significance,\N,intron_variant,5.225,0.001,1KG_SAS_AF,OTOA
390131,16:21763107:C>T,NM_144672.3:c.2776-149C>T,\N,\N,23/27,Unknown significance,\N,intron_variant,1.435,0.0008,1KG_AFR_AF,OTOA
390132,16:21763151:T>A,NM_144672.3:c.2776-105T>A,\N,\N,23/27,Unknown significance,\N,intron_variant,2.244,\N,\N,OTOA
390133,16:21763214:T>C,NM_144672.3:c.2776-42T>C,\N,\N,23/27,Benign,\N,intron_variant,0.77,0.0833333,EXAC_EAS_AF,OTOA
390134,16:21763235:T>C,NM_144672.3:c.2776-21T>C,\N,\N,23/27,Benign,\N,intron_variant,3.907,0.0274,1KG_AMR_AF,OTOA
390135,16:21763275:G>C,NM_144672.3:c.2795G>C,NP_653273.3:p.Gly932Ala,24/28,\N,Likely Pathogenic,DFNB22,missense_variant,20.8,\N,\N,OTOA
390136,16:21763280:C>T,NM_144672.3:c.2800C>T,NP_653273.3:p.Leu934=,24/28,\N,Benign,\N,synonymous_variant,10.45,0.03125,EXAC_SAS_AF,OTOA
390137,16:21763389:C>T,NM_144672.3:c.2909C>T,NP_653273.3:p.Ser970Leu,24/28,\N,Likely benign,\N,missense_variant,19.62,0.001,1KG_SAS_AF,OTOA
390138,16:21763437:AATTC>A,NM_144672.3:c.2918+42_2918+45del,\N,\N,24/27,Unknown significance,\N,intron_variant,14.63,\N,\N,OTOA
390139,16:21763440:T>C,NM_144672.3:c.2918+42T>C,\N,\N,24/27,Unknown significance,\N,intron_variant,0.192,\N,\N,OTOA
390140,16:21763440:T>TCATC,NM_144672.3:c.2918+89_2918+92dup,\N,\N,24/27,Benign,\N,intron_variant,14.69,0.4667,1KG_AFR_AF,OTOA
390141,16:21763440:T>TCATCCATC,NM_144672.3:c.2918+85_2918+92dup,\N,\N,24/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
390142,16:21763440:TCATC>T,NM_144672.3:c.2918+89_2918+92del,\N,\N,24/27,Unknown significance,\N,intron_variant,17.14,\N,\N,OTOA
390143,16:21763440:TCATCCATCCATCCATCCATC>T,NM_144672.3:c.2918+73_2918+92del,\N,\N,24/27,Unknown significance,\N,intron_variant,16.3,\N,\N,OTOA
390144,16:21763553:A>G,NM_144672.3:c.2919-137A>G,\N,\N,24/27,Unknown significance,\N,intron_variant,2.591,\N,\N,OTOA
390145,16:21763564:GC>G,NM_144672.3:c.2919-125del,\N,\N,24/27,Unknown significance,\N,intron_variant,1.225,\N,\N,OTOA
390146,16:21763568:T>C,NM_144672.3:c.2919-122T>C,\N,\N,24/27,Benign,\N,intron_variant,0.832,0.1431,1KG_SAS_AF,OTOA
390147,16:21763602:A>G,NM_144672.3:c.2919-88A>G,\N,\N,24/27,Benign,\N,intron_variant,0.16,0.1442,1KG_SAS_AF,OTOA
390148,16:21763624:GTT>G,NM_144672.3:c.2919-64_2919-63del,\N,\N,24/27,Benign,\N,intron_variant,4.611,0.249,1KG_EAS_AF,OTOA
390149,16:21763626:T>G,NM_144672.3:c.2919-64T>G,\N,\N,24/27,Unknown significance,\N,intron_variant,3.424,\N,\N,OTOA
390150,16:21763626:T>TGTG,NM_144672.3:c.2919-64_2919-63insGTG,\N,\N,24/27,Unknown significance,\N,intron_variant,2.244,\N,\N,OTOA
390151,16:21763639:G>T,NM_144672.3:c.2919-51G>T,\N,\N,24/27,Unknown significance,\N,intron_variant,0.928,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
390152,16:21763641:T>C,NM_144672.3:c.2919-49T>C,\N,\N,24/27,Unknown significance,\N,intron_variant,4.705,\N,\N,OTOA
390153,16:21763644:A>G,NM_144672.3:c.2919-46A>G,\N,\N,24/27,Benign,\N,intron_variant,5.621,0.0159,1KG_AMR_AF,OTOA
390154,16:21763650:C>A,NM_144672.3:c.2919-40C>A,\N,\N,24/27,Unknown significance,\N,intron_variant,5.209,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
390155,16:21763652:A>G,NM_144672.3:c.2919-38A>G,\N,\N,24/27,Unknown significance,\N,intron_variant,4.914,\N,\N,OTOA
390156,16:21763657:A>G,NM_144672.3:c.2919-33A>G,\N,\N,24/27,Unknown significance,\N,intron_variant,4.095,\N,\N,OTOA
390157,16:21763667:C>T,NM_144672.3:c.2919-23C>T,\N,\N,24/27,Unknown significance,\N,intron_variant,2.838,\N,\N,OTOA
390158,16:21763668:C>T,NM_144672.3:c.2919-22C>T,\N,\N,24/27,Unknown significance,\N,intron_variant,1.68,\N,\N,OTOA
390159,16:21763673:T>A,NM_144672.3:c.2919-17T>A,\N,\N,24/27,Unknown significance,\N,intron_variant,8.832,\N,\N,OTOA
390160,16:21763680:C>T,NM_144672.3:c.2919-10C>T,\N,\N,24/27,Unknown significance,\N,intron_variant,13.62,\N,\N,OTOA
390161,16:21763691:G>A,NM_144672.3:c.2920G>A,NP_653273.3:p.Val974Met,25/28,\N,Likely benign,\N,missense_variant&splice_region_variant,15.97,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
390162,16:21763698:T>A,NM_144672.3:c.2927T>A,NP_653273.3:p.Val976Glu,25/28,\N,Unknown significance,\N,missense_variant,28.3,\N,\N,OTOA
390163,16:21763714:C>T,NM_144672.3:c.2943C>T,NP_653273.3:p.Thr981=,25/28,\N,Unknown significance,\N,synonymous_variant,11.72,\N,\N,OTOA
390164,16:21763716:T>C,NM_144672.3:c.2945T>C,NP_653273.3:p.Leu982Pro,25/28,\N,Unknown significance,\N,missense_variant,25.5,\N,\N,OTOA
390165,16:21763730:CAT>C,NM_144672.3:c.2960_2961del,NP_653273.3:p.His987ArgfsTer6,25/28,\N,Unknown significance,\N,frameshift_variant,25.3,0.000322997,EXAC_AMR_AF,OTOA
390166,16:21763731:A>G,NM_144672.3:c.2960A>G,NP_653273.3:p.His987Arg,25/28,\N,Likely benign,\N,missense_variant,0.003,\N,\N,OTOA
390167,16:21763741:C>T,NM_144672.3:c.2970C>T,NP_653273.3:p.Ala990=,25/28,\N,Benign,\N,synonymous_variant,14.26,0.0477,1KG_AFR_AF,OTOA
390168,16:21763742:G>A,NM_001161683.1:c.2734G>A,NP_001155155.1:p.Glu912Lys,21/24,\N,Unknown significance,\N,missense_variant,24.2,\N,\N,OTOA
390169,16:21763753:G>A,NM_144672.3:c.2982G>A,NP_653273.3:p.Arg994=,25/28,\N,Unknown significance,\N,synonymous_variant,8.13,\N,\N,OTOA
390170,16:21763762:A>G,NM_144672.3:c.2991A>G,NP_653273.3:p.Glu997=,25/28,\N,Unknown significance,\N,synonymous_variant,0.922,\N,\N,OTOA
390171,16:21763773:G>A,NM_144672.3:c.3002G>A,NP_653273.3:p.Gly1001Glu,25/28,\N,Unknown significance,\N,missense_variant,27.1,0.0014,1KG_AMR_AF,OTOA
390172,16:21763821:T>C,NM_144672.3:c.3050T>C,NP_653273.3:p.Ile1017Thr,25/28,\N,Unknown significance,\N,missense_variant,25.7,\N,\N,OTOA
390173,16:21763853:C>A,NM_144672.3:c.3055+27C>A,\N,\N,25/27,Unknown significance,\N,intron_variant,4.955,\N,\N,OTOA
390174,16:21763863:C>T,NM_144672.3:c.3055+37C>T,\N,\N,25/27,Unknown significance,\N,intron_variant,11.89,0.000896057,EXAC_NFE_AF,OTOA
390175,16:21763874:T>A,NM_144672.3:c.3055+48T>A,\N,\N,25/27,Benign,\N,intron_variant,8.023,0.00549451,EXAC_SAS_AF,OTOA
390176,16:21763930:G>A,NM_144672.3:c.3055+104G>A,\N,\N,25/27,Unknown significance,\N,intron_variant,0.154,0.0008,1KG_AFR_AF,OTOA
390177,16:21764232:T>C,NM_144672.3:c.3056-116T>C,\N,\N,25/27,Unknown significance,\N,intron_variant,15.24,0.0014,1KG_AMR_AF,OTOA
390178,16:21764268:A>G,NM_144672.3:c.3056-80A>G,\N,\N,25/27,Unknown significance,\N,intron_variant,13.43,\N,\N,OTOA
390179,16:21764297:C>T,NM_144672.3:c.3056-51C>T,\N,\N,25/27,Unknown significance,\N,intron_variant,15,0.000455996,EVS_AA_AF,OTOA
390180,16:21764298:G>A,NM_144672.3:c.3056-50G>A,\N,\N,25/27,Unknown significance,\N,intron_variant,12.45,\N,\N,OTOA
390181,16:21764301:G>T,NM_144672.3:c.3056-47G>T,\N,\N,25/27,Unknown significance,\N,intron_variant,14.87,0.001,1KG_EUR_AF,OTOA
390182,16:21764302:T>C,NM_144672.3:c.3056-46T>C,\N,\N,25/27,Unknown significance,\N,intron_variant,15.61,\N,\N,OTOA
390183,16:21764308:T>C,NM_144672.3:c.3056-40T>C,\N,\N,25/27,Unknown significance,\N,intron_variant,15.89,\N,\N,OTOA
390184,16:21764311:C>T,NM_144672.3:c.3056-37C>T,\N,\N,25/27,Unknown significance,\N,intron_variant,17.12,\N,\N,OTOA
390185,16:21764316:A>G,NM_144672.3:c.3056-32A>G,\N,\N,25/27,Unknown significance,\N,intron_variant,16.7,\N,\N,OTOA
390186,16:21764321:AC>A,NM_144672.3:c.3056-22del,\N,\N,25/27,Unknown significance,\N,intron_variant,14.33,\N,\N,OTOA
390187,16:21764322:C>A,NM_144672.3:c.3056-26C>A,\N,\N,25/27,Unknown significance,\N,intron_variant,17.36,\N,\N,OTOA
390188,16:21764324:C>G,NM_144672.3:c.3056-24C>G,\N,\N,25/27,Unknown significance,\N,intron_variant,15.03,\N,\N,OTOA
390189,16:21764325:C>T,NM_144672.3:c.3056-23C>T,\N,\N,25/27,Unknown significance,\N,intron_variant,15.55,\N,\N,OTOA
390190,16:21764326:C>T,NM_144672.3:c.3056-22C>T,\N,\N,25/27,Unknown significance,\N,intron_variant,14.92,0.002,1KG_SAS_AF,OTOA
390191,16:21764327:G>A,NM_144672.3:c.3056-21G>A,\N,\N,25/27,Benign,\N,intron_variant,15.41,0.0061,1KG_SAS_AF,OTOA
390192,16:21764329:GAT>G,NM_144672.3:c.3056-18_3056-17del,\N,\N,25/27,Unknown significance,\N,intron_variant,16.78,\N,\N,OTOA
390193,16:21764343:C>T,NM_144672.3:c.3056-5C>T,\N,\N,25/27,Unknown significance,\N,splice_region_variant&intron_variant,16.28,0.0008,1KG_AFR_AF,OTOA
390194,16:21764345:C>A,NM_144672.3:c.3056-3C>A,\N,\N,25/27,Unknown significance,\N,splice_region_variant&intron_variant,16.54,\N,\N,OTOA
390195,16:21764362:G>C,NM_144672.3:c.3070G>C,NP_653273.3:p.Ala1024Pro,26/28,\N,Likely benign,\N,missense_variant,22.4,0.002,1KG_EAS_AF,OTOA
390196,16:21764363:C>T,NM_144672.3:c.3071C>T,NP_653273.3:p.Ala1024Val,26/28,\N,Likely benign,\N,missense_variant,21.7,\N,\N,OTOA
390197,16:21764366:A>C,NM_144672.3:c.3074A>C,NP_653273.3:p.Glu1025Ala,26/28,\N,Unknown significance,\N,missense_variant,27,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
390198,16:21764367:G>A,NM_144672.3:c.3075G>A,NP_653273.3:p.Glu1025=,26/28,\N,Unknown significance,\N,synonymous_variant,9.397,0.00106257,EVS_EA_AF,OTOA
390199,16:21764371:C>T,NM_144672.3:c.3079C>T,NP_653273.3:p.Arg1027Trp,26/28,\N,Unknown significance,\N,missense_variant,35,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
390200,16:21764372:G>A,NM_144672.3:c.3080G>A,NP_653273.3:p.Arg1027Gln,26/28,\N,Likely benign,\N,missense_variant,14.41,0.002,1KG_SAS_AF,OTOA
390201,16:21764376:G>T,NM_144672.3:c.3084G>T,NP_653273.3:p.Met1028Ile,26/28,\N,Likely benign,\N,missense_variant,6.314,\N,\N,OTOA
390202,16:21764380:G>A,NM_144672.3:c.3088G>A,NP_653273.3:p.Asp1030Asn,26/28,\N,Likely benign,\N,missense_variant,10.31,\N,\N,OTOA
390203,16:21764386:G>A,NM_144672.3:c.3094G>A,NP_653273.3:p.Asp1032Asn,26/28,\N,Likely benign,\N,missense_variant,21.6,\N,\N,OTOA
390204,16:21764388:T>A,NM_144672.3:c.3096T>A,NP_653273.3:p.Asp1032Glu,26/28,\N,Likely benign,\N,missense_variant,8.649,\N,\N,OTOA
390205,16:21764397:A>C,NM_144672.3:c.3105A>C,NP_653273.3:p.Pro1035=,26/28,\N,Unknown significance,\N,synonymous_variant,0.609,\N,\N,OTOA
390206,16:21764397:A>G,NM_144672.3:c.3105A>G,NP_653273.3:p.Pro1035=,26/28,\N,Unknown significance,\N,synonymous_variant,6.192,\N,\N,OTOA
390207,16:21764404:CA>C,NM_144672.3:c.3113del,NP_653273.3:p.Gln1038ArgfsTer5,26/28,\N,Unknown significance,\N,frameshift_variant,35,\N,\N,OTOA
390208,16:21764409:A>G,NM_144672.3:c.3117A>G,NP_653273.3:p.Pro1039=,26/28,\N,Unknown significance,\N,synonymous_variant,8.146,\N,\N,OTOA
390209,16:21764433:T>A,NM_144672.3:c.3141T>A,NP_653273.3:p.Asp1047Glu,26/28,\N,Likely benign,\N,missense_variant,11.53,\N,\N,OTOA
390210,16:21764437:A>G,NM_144672.3:c.3145A>G,NP_653273.3:p.Ile1049Val,26/28,\N,Likely benign,\N,missense_variant,4.232,\N,\N,OTOA
390211,16:21764442:C>A,NM_144672.3:c.3150C>A,NP_653273.3:p.Phe1050Leu,26/28,\N,Unknown significance,\N,missense_variant,23.3,\N,\N,OTOA
390212,16:21764448:A>C,NM_144672.3:c.3153+3A>C,\N,\N,26/27,Unknown significance,\N,splice_region_variant&intron_variant,13.77,\N,\N,OTOA
390213,16:21764451:T>A,NM_144672.3:c.3153+6T>A,\N,\N,26/27,Unknown significance,\N,splice_region_variant&intron_variant,14.49,\N,\N,OTOA
390214,16:21764455:C>G,NM_144672.3:c.3153+10C>G,\N,\N,26/27,Unknown significance,\N,intron_variant,15.86,\N,\N,OTOA
390215,16:21764460:C>T,NM_144672.3:c.3153+15C>T,\N,\N,26/27,Unknown significance,\N,intron_variant,16.54,\N,\N,OTOA
390216,16:21764463:CA>C,NM_144672.3:c.3153+20del,\N,\N,26/27,Unknown significance,\N,intron_variant,21.1,\N,\N,OTOA
390217,16:21764466:G>A,NM_144672.3:c.3153+21G>A,\N,\N,26/27,Unknown significance,\N,intron_variant,21.2,0.002,1KG_EAS_AF,OTOA
390218,16:21764468:A>C,NM_144672.3:c.3153+23A>C,\N,\N,26/27,Unknown significance,\N,intron_variant,18.84,\N,\N,OTOA
390219,16:21764473:T>G,NM_144672.3:c.3153+28T>G,\N,\N,26/27,Unknown significance,\N,intron_variant,16.45,0.00293351,EVS_AA_AF,OTOA
390220,16:21764483:AC>A,NM_144672.3:c.3153+42del,\N,\N,26/27,Unknown significance,\N,intron_variant,17.92,\N,\N,OTOA
390221,16:21764584:T>C,NM_144672.3:c.3153+139T>C,\N,\N,26/27,Unknown significance,\N,intron_variant,2.618,0.002,1KG_EAS_AF,OTOA
390222,16:21764620:A>G,NM_144672.3:c.3153+175A>G,\N,\N,26/27,Benign,\N,intron_variant,2.873,0.0069,1KG_EAS_AF,OTOA
390223,16:21764945:A>C,NM_144672.3:c.3153+500A>C,\N,\N,26/27,Benign,\N,intron_variant,8.636,0.0188,1KG_EAS_AF,OTOA
390224,16:21765242:G>A,NM_144672.3:c.3153+797G>A,\N,\N,26/27,Benign,\N,intron_variant,1,0.0327,1KG_SAS_AF,OTOA
390225,16:21765255:C>G,NM_144672.3:c.3153+810C>G,\N,\N,26/27,Unknown significance,\N,intron_variant,1.398,0.002,1KG_EUR_AF,OTOA
390226,16:21765364:A>G,NM_144672.3:c.3153+919A>G,\N,\N,26/27,Unknown significance,\N,intron_variant,6.854,0.001,1KG_SAS_AF,OTOA
390227,16:21765385:C>A,NM_144672.3:c.3153+940C>A,\N,\N,26/27,Benign,\N,intron_variant,5.805,0.2382,1KG_SAS_AF,OTOA
390228,16:21765385:C>CTA,NM_144672.3:c.3153+941_3153+942insAT,\N,\N,26/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
390229,16:21765387:C>A,NM_144672.3:c.3153+942C>A,\N,\N,26/27,Benign,\N,intron_variant,5.117,0.1619,1KG_AFR_AF,OTOA
390230,16:21765397:A>T,NM_144672.3:c.3153+952A>T,\N,\N,26/27,Unknown significance,\N,intron_variant,0.054,0.0015,1KG_AFR_AF,OTOA
390231,16:21765399:A>AT,NM_144672.3:c.3153+961dup,\N,\N,26/27,Unknown significance,\N,intron_variant,0.081,\N,\N,OTOA
390232,16:21765399:A>ATATAT,NM_144672.3:c.3153+955_3153+956insATATT,\N,\N,26/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
390233,16:21765399:A>T,NM_144672.3:c.3153+954A>T,\N,\N,26/27,Unknown significance,\N,intron_variant,0.471,\N,\N,OTOA
390234,16:21765401:T>A,NM_144672.3:c.3153+956T>A,\N,\N,26/27,Unknown significance,\N,intron_variant,5.482,0.001,1KG_EAS_AF,OTOA
390235,16:21765419:A>T,NM_144672.3:c.3153+974A>T,\N,\N,26/27,Unknown significance,\N,intron_variant,0.016,0.0045,1KG_AFR_AF,OTOA
390236,16:21765800:CGAG>C,NM_144672.3:c.3153+1360_3153+1362del,\N,\N,26/27,Benign,\N,intron_variant,\N,0.0069,1KG_EAS_AF,OTOA
390237,16:21765817:C>G,NM_144672.3:c.3153+1372C>G,\N,\N,26/27,Unknown significance,\N,intron_variant,0.494,\N,\N,OTOA
390238,16:21765833:G>A,NM_144672.3:c.3153+1388G>A,\N,\N,26/27,Unknown significance,\N,intron_variant,0.913,0.0038,1KG_AFR_AF,OTOA
390239,16:21765850:T>G,NM_144672.3:c.3153+1405T>G,\N,\N,26/27,Unknown significance,\N,intron_variant,1.285,0.001,1KG_EAS_AF,OTOA
390240,16:21766186:G>T,NM_144672.3:c.3153+1741G>T,\N,\N,26/27,Unknown significance,\N,intron_variant,0.286,\N,\N,OTOA
390241,16:21766192:G>T,NM_144672.3:c.3153+1747G>T,\N,\N,26/27,Unknown significance,\N,intron_variant,0.307,\N,\N,OTOA
390242,16:21766421:G>A,NM_144672.3:c.3153+1976G>A,\N,\N,26/27,Unknown significance,\N,intron_variant,2.239,0.0014,1KG_AMR_AF,OTOA
390243,16:21766513:A>G,NM_144672.3:c.3154-1890A>G,\N,\N,26/27,Unknown significance,\N,intron_variant,4.918,\N,\N,OTOA
390244,16:21766768:CGT>C,NM_144672.3:c.3154-1592_3154-1591del,\N,\N,26/27,Benign,\N,intron_variant,4.997,0.4591,1KG_SAS_AF,OTOA
390245,16:21766768:CGTGT>C,NM_144672.3:c.3154-1594_3154-1591del,\N,\N,26/27,Unknown significance,\N,intron_variant,6.847,\N,\N,OTOA
390246,16:21766960:A>G,NM_144672.3:c.3154-1443A>G,\N,\N,26/27,Unknown significance,\N,intron_variant,7.858,0.0008,1KG_AFR_AF,OTOA
390247,16:21767119:G>A,NM_144672.3:c.3154-1284G>A,\N,\N,26/27,Unknown significance,\N,intron_variant,0.165,0.002,1KG_EAS_AF,OTOA
390248,16:21767184:G>A,NM_144672.3:c.3154-1219G>A,\N,\N,26/27,Unknown significance,\N,intron_variant,1.433,0.002,1KG_SAS_AF,OTOA
390249,16:21767231:C>T,NM_144672.3:c.3154-1172C>T,\N,\N,26/27,Unknown significance,\N,intron_variant,3.506,0.0014,1KG_AMR_AF,OTOA
390250,16:21767490:G>A,NM_144672.3:c.3154-913G>A,\N,\N,26/27,Unknown significance,\N,intron_variant,0.796,0.001,1KG_EAS_AF|1KG_EUR_AF,OTOA
390251,16:21767586:T>C,NM_144672.3:c.3154-817T>C,\N,\N,26/27,Benign,\N,intron_variant,0.719,0.2837,1KG_EAS_AF,OTOA
390252,16:21767596:T>C,NM_144672.3:c.3154-807T>C,\N,\N,26/27,Unknown significance,\N,intron_variant,3.783,\N,\N,OTOA
390253,16:21767607:T>C,NM_144672.3:c.3154-796T>C,\N,\N,26/27,Unknown significance,\N,intron_variant,5.679,0.0008,1KG_AFR_AF,OTOA
390254,16:21767630:T>C,NM_144672.3:c.3154-773T>C,\N,\N,26/27,Unknown significance,\N,intron_variant,3.623,0.0008,1KG_AFR_AF,OTOA
390255,16:21767710:A>T,NM_144672.3:c.3154-693A>T,\N,\N,26/27,Unknown significance,\N,intron_variant,12.95,0.001,1KG_SAS_AF,OTOA
390256,16:21767738:A>G,NM_144672.3:c.3154-665A>G,\N,\N,26/27,Unknown significance,\N,intron_variant,5.313,0,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,OTOA
390257,16:21767743:G>A,NM_144672.3:c.3154-660G>A,\N,\N,26/27,Unknown significance,\N,intron_variant,3.003,\N,\N,OTOA
390258,16:21767768:C>G,NM_144672.3:c.3154-635C>G,\N,\N,26/27,Unknown significance,\N,intron_variant,2.333,\N,\N,OTOA
390259,16:21767869:C>T,NM_144672.3:c.3154-534C>T,\N,\N,26/27,Benign,\N,intron_variant,2.161,0.2744,1KG_EUR_AF,OTOA
390260,16:21767902:A>G,NM_144672.3:c.3154-501A>G,\N,\N,26/27,Unknown significance,\N,intron_variant,2.254,0.0008,1KG_AFR_AF,OTOA
390261,16:21767916:C>T,NM_144672.3:c.3154-487C>T,\N,\N,26/27,Unknown significance,\N,intron_variant,3.563,\N,\N,OTOA
390262,16:21767923:G>A,NM_144672.3:c.3154-480G>A,\N,\N,26/27,Unknown significance,\N,intron_variant,3.987,0.001,1KG_SAS_AF,OTOA
390263,16:21767924:C>A,NM_144672.3:c.3154-479C>A,\N,\N,26/27,Unknown significance,\N,intron_variant,1.73,0.001,1KG_SAS_AF,OTOA
390264,16:21767964:C>T,NM_144672.3:c.3154-439C>T,\N,\N,26/27,Unknown significance,\N,intron_variant,0.624,0.001,1KG_SAS_AF,OTOA
390265,16:21767973:C>T,NM_144672.3:c.3154-430C>T,\N,\N,26/27,Unknown significance,\N,intron_variant,1.219,0.001,1KG_SAS_AF,OTOA
390266,16:21767997:C>T,NM_144672.3:c.3154-406C>T,\N,\N,26/27,Benign,\N,intron_variant,1.044,0.007,1KG_EUR_AF,OTOA
390267,16:21768030:G>A,NM_144672.3:c.3154-373G>A,\N,\N,26/27,Unknown significance,\N,intron_variant,1.224,\N,\N,OTOA
390268,16:21768041:A>G,NM_144672.3:c.3154-362A>G,\N,\N,26/27,Unknown significance,\N,intron_variant,0.498,0.001,1KG_EAS_AF,OTOA
390269,16:21768065:C>T,NM_144672.3:c.3154-338C>T,\N,\N,26/27,Benign,\N,intron_variant,1.341,0.0136,1KG_AFR_AF,OTOA
390270,16:21768095:C>T,NM_144672.3:c.3154-308C>T,\N,\N,26/27,Unknown significance,\N,intron_variant,10.42,\N,\N,OTOA
390271,16:21768120:A>G,NM_144672.3:c.3154-283A>G,\N,\N,26/27,Unknown significance,\N,intron_variant,6.145,0.0008,1KG_AFR_AF,OTOA
390272,16:21768137:A>G,NM_144672.3:c.3154-266A>G,\N,\N,26/27,Unknown significance,\N,intron_variant,0.337,0.0014,1KG_AMR_AF,OTOA
390273,16:21768530:C>T,NM_144672.3:c.3281C>T,NP_653273.3:p.Thr1094Ile,27/28,\N,Likely benign,\N,missense_variant,11.14,\N,\N,OTOA
390274,16:21768840:G>A,NM_144672.3:c.3349+242G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,1.51,\N,\N,OTOA
390275,16:21768862:A>G,NM_144672.3:c.3349+264A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,1.857,0.003,1KG_EAS_AF,OTOA
390276,16:21768871:T>G,NM_144672.3:c.3349+273T>G,\N,\N,27/27,Unknown significance,\N,intron_variant,4.524,0.002,1KG_EUR_AF,OTOA
390277,16:21768874:G>A,NM_144672.3:c.3349+276G>A,\N,\N,27/27,Benign,\N,intron_variant,3.924,0.0188,1KG_EAS_AF,OTOA
390278,16:21768936:C>CTATTATTATTATTATTATTATTAT,NM_144672.3:c.3349+357_3349+358insATTATTATTATTATTATTATTATT,\N,\N,27/27,Benign,\N,intron_variant,\N,0.0272,1KG_AFR_AF,OTOA
390279,16:21769064:C>T,NM_144672.3:c.3349+466C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,7.018,0.003,1KG_AFR_AF,OTOA
390280,16:21769079:C>T,NM_144672.3:c.3349+481C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,7.694,\N,\N,OTOA
390281,16:21769120:G>T,NM_144672.3:c.3349+522G>T,\N,\N,27/27,Benign,\N,intron_variant,3.783,0.0216,1KG_AMR_AF,OTOA
390282,16:21769163:T>C,NM_144672.3:c.3349+565T>C,\N,\N,27/27,Unknown significance,\N,intron_variant,2.077,0.0008,1KG_AFR_AF,OTOA
390283,16:21769185:C>T,NM_144672.3:c.3349+587C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,3.559,0.002,1KG_EUR_AF,OTOA
390284,16:21769193:C>T,NM_144672.3:c.3349+595C>T,\N,\N,27/27,Benign,\N,intron_variant,4.363,0.006,1KG_EAS_AF,OTOA
390285,16:21769214:C>G,NM_144672.3:c.3349+616C>G,\N,\N,27/27,Unknown significance,\N,intron_variant,4.665,\N,\N,OTOA
390286,16:21769296:C>T,NM_144672.3:c.3349+698C>T,\N,\N,27/27,Benign,\N,intron_variant,2.76,0.0432,1KG_AMR_AF,OTOA
390287,16:21769300:G>C,NM_144672.3:c.3349+702G>C,\N,\N,27/27,Unknown significance,\N,intron_variant,0.092,0.001,1KG_EUR_AF,OTOA
390288,16:21769324:A>T,NM_144672.3:c.3349+726A>T,\N,\N,27/27,Unknown significance,\N,intron_variant,4.277,\N,\N,OTOA
390289,16:21769325:C>G,NM_144672.3:c.3349+727C>G,\N,\N,27/27,Unknown significance,\N,intron_variant,3.151,\N,\N,OTOA
390290,16:21769331:T>C,NM_144672.3:c.3349+733T>C,\N,\N,27/27,Unknown significance,\N,intron_variant,4.602,0.002,1KG_EUR_AF,OTOA
390291,16:21769371:C>A,NM_144672.3:c.3349+773C>A,\N,\N,27/27,Unknown significance,\N,intron_variant,8.691,0.003,1KG_EAS_AF,OTOA
390292,16:21769523:C>T,NM_144672.3:c.3349+925C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,3.598,\N,\N,OTOA
390293,16:21769537:A>G,NM_144672.3:c.3349+939A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,1.011,\N,\N,OTOA
390294,16:21769540:A>C,NM_144672.3:c.3349+942A>C,\N,\N,27/27,Unknown significance,\N,intron_variant,1.884,0.001,1KG_EAS_AF,OTOA
390295,16:21769542:T>G,NM_144672.3:c.3349+944T>G,\N,\N,27/27,Unknown significance,\N,intron_variant,4.181,0.001,1KG_SAS_AF,OTOA
390296,16:21769548:T>C,NM_144672.3:c.3349+950T>C,\N,\N,27/27,Unknown significance,\N,intron_variant,1.295,0.001,1KG_SAS_AF,OTOA
390297,16:21769558:A>G,NM_144672.3:c.3349+960A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,4.78,\N,\N,OTOA
390298,16:21769586:C>A,NM_144672.3:c.3349+988C>A,\N,\N,27/27,Unknown significance,\N,intron_variant,5.918,0.0008,1KG_AFR_AF,OTOA
390299,16:21769597:A>T,NM_144672.3:c.3349+999A>T,\N,\N,27/27,Unknown significance,\N,intron_variant,0.226,0.001,1KG_EAS_AF,OTOA
390300,16:21769619:G>A,NM_144672.3:c.3349+1021G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,2.283,\N,\N,OTOA
390301,16:21769625:A>G,NM_144672.3:c.3349+1027A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,0.376,\N,\N,OTOA
390302,16:21769677:C>CAT,NM_144672.3:c.3349+1080_3349+1081dup,\N,\N,27/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
390303,16:21769677:CAT>C,NM_144672.3:c.3349+1080_3349+1081del,\N,\N,27/27,Benign,\N,intron_variant,3.611,0.0368,1KG_EUR_AF,OTOA
390304,16:21769704:G>A,NM_144672.3:c.3349+1106G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,3.467,0.0014,1KG_AMR_AF,OTOA
390305,16:21769710:C>A,NM_144672.3:c.3349+1112C>A,\N,\N,27/27,Benign,\N,intron_variant,0.673,0.0112,1KG_SAS_AF,OTOA
390306,16:21769816:C>T,NM_144672.3:c.3349+1218C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,2.333,0.0008,1KG_AFR_AF,OTOA
390307,16:21769951:A>G,NM_144672.3:c.3349+1353A>G,\N,\N,27/27,Benign,\N,intron_variant,4.343,0.3016,1KG_EAS_AF,OTOA
390308,16:21770002:G>A,NM_144672.3:c.3349+1404G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,0.998,0.0008,1KG_AFR_AF,OTOA
390309,16:21770007:A>G,NM_144672.3:c.3349+1409A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,2.427,\N,\N,OTOA
390310,16:21770139:A>G,NM_144672.3:c.3349+1541A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,1.076,0.002,1KG_SAS_AF,OTOA
390311,16:21770142:G>A,NM_144672.3:c.3349+1544G>A,\N,\N,27/27,Benign,\N,intron_variant,1.97,0.0091,1KG_AFR_AF,OTOA
390312,16:21770152:G>A,NM_144672.3:c.3349+1554G>A,\N,\N,27/27,Benign,\N,intron_variant,0.327,0.0068,1KG_AFR_AF,OTOA
390313,16:21770161:A>G,NM_144672.3:c.3349+1563A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,2.348,0.0014,1KG_AMR_AF,OTOA
390314,16:21770174:T>C,NM_144672.3:c.3349+1576T>C,\N,\N,27/27,Unknown significance,\N,intron_variant,1.674,0.0014,1KG_AMR_AF,OTOA
390315,16:21770180:G>A,NM_144672.3:c.3349+1582G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,0.407,\N,\N,OTOA
390316,16:21770190:G>A,NM_144672.3:c.3349+1592G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,1.833,\N,\N,OTOA
390317,16:21770340:C>CA,NM_144672.3:c.3350-1443dup,\N,\N,27/27,Unknown significance,\N,intron_variant,\N,\N,\N,OTOA
390318,16:21770366:A>G,NM_144672.3:c.3350-1425A>G,\N,\N,27/27,Benign,\N,intron_variant,4.018,0.2894,1KG_SAS_AF,OTOA
390319,16:21770368:A>G,NM_144672.3:c.3350-1423A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,1.448,\N,\N,OTOA
390320,16:21770380:G>A,NM_144672.3:c.3350-1411G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,0.799,\N,\N,OTOA
390321,16:21770405:G>A,NM_144672.3:c.3350-1386G>A,\N,\N,27/27,Benign,\N,intron_variant,0.632,0.2535,1KG_EUR_AF,OTOA
390322,16:21770444:C>T,NM_144672.3:c.3350-1347C>T,\N,\N,27/27,Benign,\N,intron_variant,2.825,0.0112,1KG_SAS_AF,OTOA
390323,16:21770448:G>A,NM_144672.3:c.3350-1343G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,2.223,0.001,1KG_EUR_AF|1KG_SAS_AF,OTOA
390324,16:21770452:C>T,NM_144672.3:c.3350-1339C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,0.775,0.001,1KG_EUR_AF|1KG_SAS_AF,OTOA
390325,16:21770459:A>G,NM_144672.3:c.3350-1332A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,2.243,\N,\N,OTOA
390326,16:21770461:A>G,NM_144672.3:c.3350-1330A>G,\N,\N,27/27,Benign,\N,intron_variant,1.228,0.0239,1KG_EUR_AF,OTOA
390327,16:21770469:C>A,NM_144672.3:c.3350-1322C>A,\N,\N,27/27,Benign,\N,intron_variant,2.408,0.3037,1KG_SAS_AF,OTOA
390328,16:21770482:G>A,NM_144672.3:c.3350-1309G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,2.542,0.001,1KG_SAS_AF,OTOA
390329,16:21770484:A>T,NM_144672.3:c.3350-1307A>T,\N,\N,27/27,Unknown significance,\N,intron_variant,2.497,\N,\N,OTOA
390330,16:21770493:C>T,NM_144672.3:c.3350-1298C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,3.252,\N,\N,OTOA
390331,16:21770516:C>T,NM_144672.3:c.3350-1275C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,3.237,0.001,1KG_EUR_AF,OTOA
390332,16:21770576:A>G,NM_144672.3:c.3350-1215A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,10.28,\N,\N,OTOA
390333,16:21770637:T>C,NM_144672.3:c.3350-1154T>C,\N,\N,27/27,Unknown significance,\N,intron_variant,7.92,\N,\N,OTOA
390334,16:21770675:A>C,NM_144672.3:c.3350-1116A>C,\N,\N,27/27,Unknown significance,\N,intron_variant,1.195,\N,\N,OTOA
390335,16:21770726:T>G,NM_144672.3:c.3350-1065T>G,\N,\N,27/27,Unknown significance,\N,intron_variant,12.57,0.001,1KG_EAS_AF|1KG_SAS_AF,OTOA
390336,16:21770742:C>T,NM_144672.3:c.3350-1049C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,11.45,0.0008,1KG_AFR_AF,OTOA
390337,16:21770744:G>A,NM_144672.3:c.3350-1047G>A,\N,\N,27/27,Benign,\N,intron_variant,9.727,0.0427,1KG_EAS_AF,OTOA
390338,16:21770810:G>T,NM_144672.3:c.3350-981G>T,\N,\N,27/27,Unknown significance,\N,intron_variant,2.46,\N,\N,OTOA
390339,16:21770912:G>T,NM_144672.3:c.3350-879G>T,\N,\N,27/27,Unknown significance,\N,intron_variant,9.352,0.001,1KG_EUR_AF,OTOA
390340,16:21770943:C>T,NM_144672.3:c.3350-848C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,0.253,\N,\N,OTOA
390341,16:21770991:G>T,NM_144672.3:c.3350-800G>T,\N,\N,27/27,Unknown significance,\N,intron_variant,0.394,0.002,1KG_SAS_AF,OTOA
390342,16:21770994:G>A,NM_144672.3:c.3350-797G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,2.368,\N,\N,OTOA
390343,16:21771004:T>C,NM_144672.3:c.3350-787T>C,\N,\N,27/27,Unknown significance,\N,intron_variant,1.527,0.0008,1KG_AFR_AF,OTOA
390344,16:21771016:A>G,NM_144672.3:c.3350-775A>G,\N,\N,27/27,Benign,\N,intron_variant,0.173,0.4931,1KG_EAS_AF,OTOA
390345,16:21771037:T>C,NM_144672.3:c.3350-754T>C,\N,\N,27/27,Unknown significance,\N,intron_variant,3.698,\N,\N,OTOA
390346,16:21771050:C>T,NM_144672.3:c.3350-741C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,7.74,\N,\N,OTOA
390347,16:21771051:G>A,NM_144672.3:c.3350-740G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,7.793,0.0008,1KG_AFR_AF,OTOA
390348,16:21771109:T>C,NM_144672.3:c.3350-682T>C,\N,\N,27/27,Unknown significance,\N,intron_variant,7.895,0.001,1KG_EAS_AF,OTOA
390349,16:21771126:C>T,NM_144672.3:c.3350-665C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,4.061,\N,\N,OTOA
390350,16:21771177:C>T,NM_144672.3:c.3350-614C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,3.116,0.0023,1KG_AFR_AF,OTOA
390351,16:21771179:C>T,NM_144672.3:c.3350-612C>T,\N,\N,27/27,Benign,\N,intron_variant,4.152,0.3027,1KG_SAS_AF,OTOA
390352,16:21771205:G>A,NM_144672.3:c.3350-586G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,1.128,\N,\N,OTOA
390353,16:21771222:A>C,NM_144672.3:c.3350-569A>C,\N,\N,27/27,Unknown significance,\N,intron_variant,0.398,0.0014,1KG_AMR_AF,OTOA
390354,16:21771223:AT>A,NM_144672.3:c.3350-557del,\N,\N,27/27,Benign,\N,intron_variant,0.544,0.2904,1KG_SAS_AF,OTOA
390355,16:21771233:T>G,NM_144672.3:c.3350-558T>G,\N,\N,27/27,Unknown significance,\N,intron_variant,6.028,\N,\N,OTOA
390356,16:21771241:T>A,NM_144672.3:c.3350-550T>A,\N,\N,27/27,Unknown significance,\N,intron_variant,10.16,\N,\N,OTOA
390357,16:21771246:T>G,NM_144672.3:c.3350-545T>G,\N,\N,27/27,Unknown significance,\N,intron_variant,10.55,0.001,1KG_SAS_AF,OTOA
390358,16:21771267:G>A,NM_144672.3:c.3350-524G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,1.191,\N,\N,OTOA
390359,16:21771308:G>A,NM_144672.3:c.3350-483G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,13.66,0.0008,1KG_AFR_AF,OTOA
390360,16:21771312:G>A,NM_144672.3:c.3350-479G>A,\N,\N,27/27,Benign,\N,intron_variant,11.69,0.0208,1KG_EAS_AF,OTOA
390361,16:21771342:C>T,NM_144672.3:c.3350-449C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,2.534,0,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,OTOA
390362,16:21771377:T>G,NM_144672.3:c.3350-414T>G,\N,\N,27/27,Unknown significance,\N,intron_variant,4.616,\N,\N,OTOA
390363,16:21771398:G>A,NM_144672.3:c.3350-393G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,3.51,0.0008,1KG_AFR_AF,OTOA
390364,16:21771445:T>C,NM_144672.3:c.3350-346T>C,\N,\N,27/27,Benign,\N,intron_variant,0.778,0.0204,1KG_AFR_AF,OTOA
390365,16:21771463:T>G,NM_144672.3:c.3350-328T>G,\N,\N,27/27,Unknown significance,\N,intron_variant,5.855,0.003,1KG_EAS_AF,OTOA
390366,16:21771543:C>T,NM_144672.3:c.3350-248C>T,\N,\N,27/27,Benign,\N,intron_variant,16.77,0.0666,1KG_EUR_AF,OTOA
390367,16:21771554:G>A,NM_144672.3:c.3350-237G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,14.11,0.0014,1KG_AMR_AF,OTOA
390368,16:21771619:T>A,NM_144672.3:c.3350-172T>A,\N,\N,27/27,Unknown significance,\N,intron_variant,7.418,0.0031,1KG_SAS_AF,OTOA
390369,16:21771645:A>G,NM_144672.3:c.3350-146A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,0.636,\N,\N,OTOA
390370,16:21771667:C>T,NM_144672.3:c.3350-124C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,2.424,\N,\N,OTOA
390371,16:21771711:C>T,NM_144672.3:c.3350-80C>T,\N,\N,27/27,Unknown significance,\N,intron_variant,5.407,\N,\N,OTOA
390372,16:21771712:G>A,NM_144672.3:c.3350-79G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,2.148,0.002,1KG_SAS_AF,OTOA
390373,16:21771726:C>G,NM_144672.3:c.3350-65C>G,\N,\N,27/27,Unknown significance,\N,intron_variant,3.752,\N,\N,OTOA
390374,16:21771743:C>T,NM_144672.3:c.3350-48C>T,\N,\N,27/27,Benign,\N,intron_variant,3.377,0.005,OTO_AJ_AF,OTOA
390375,16:21771749:G>A,NM_144672.3:c.3350-42G>A,\N,\N,27/27,Unknown significance,\N,intron_variant,3.172,\N,\N,OTOA
390376,16:21771751:C>T,NM_144672.3:c.3350-40C>T,\N,\N,27/27,Benign,\N,intron_variant,0.862,0.005,OTO_TR_AF,OTOA
390377,16:21771754:A>G,NM_144672.3:c.3350-37A>G,\N,\N,27/27,Unknown significance,\N,intron_variant,0.935,\N,\N,OTOA
390378,16:21771755:A>T,NM_144672.3:c.3350-36A>T,\N,\N,27/27,Unknown significance,\N,intron_variant,1.531,\N,\N,OTOA
390379,16:21771756:C>A,NM_144672.3:c.3350-35C>A,\N,\N,27/27,Unknown significance,\N,intron_variant,4.087,\N,\N,OTOA
390380,16:21771757:T>A,NM_144672.3:c.3350-34T>A,\N,\N,27/27,Unknown significance,\N,intron_variant,4.818,0.002,1KG_EUR_AF,OTOA
390381,16:21771758:T>A,NM_144672.3:c.3350-33T>A,\N,\N,27/27,Unknown significance,\N,intron_variant,5.171,\N,\N,OTOA
390382,16:21771778:T>C,NM_144672.3:c.3350-13T>C,\N,\N,27/27,Unknown significance,\N,intron_variant,7.565,\N,\N,OTOA
390383,16:21771784:C>T,NM_144672.3:c.3350-7C>T,\N,\N,27/27,Unknown significance,\N,splice_region_variant&intron_variant,9.026,\N,\N,OTOA
390384,16:21771785:T>C,NM_144672.3:c.3350-6T>C,\N,\N,27/27,Unknown significance,\N,splice_region_variant&intron_variant,6.727,\N,\N,OTOA
390385,16:21771802:T>A,NM_144672.3:c.3361T>A,NP_653273.3:p.Ser1121Thr,28/28,\N,Likely benign,\N,missense_variant,0.003,0.000116442,EVS_EA_AF,OTOA
390386,16:21771803:C>T,NM_144672.3:c.3362C>T,NP_653273.3:p.Ser1121Leu,28/28,\N,Likely benign,\N,missense_variant,9.422,\N,\N,OTOA
390387,16:21771804:G>A,NM_144672.3:c.3363G>A,NP_653273.3:p.Ser1121=,28/28,\N,Unknown significance,\N,synonymous_variant,0.924,0.002,1KG_EAS_AF,OTOA
390388,16:21771818:T>C,NM_170664.2:c.2405T>C,NP_733764.1:p.Leu802Pro,19/19,\N,Unknown significance,\N,missense_variant,23.5,0.0014,1KG_AMR_AF,OTOA
390389,16:21771820:G>C,NM_170664.2:c.2407G>C,NP_733764.1:p.Gly803Arg,19/19,\N,Unknown significance,\N,missense_variant,23.8,\N,\N,OTOA
390390,16:21771838:C>G,NM_144672.3:c.3397C>G,NP_653273.3:p.Leu1133Val,28/28,\N,Likely benign,\N,missense_variant,1.713,0.0008,1KG_AFR_AF,OTOA
390391,16:21771841:A>C,NM_144672.3:c.3400A>C,NP_653273.3:p.Met1134Leu,28/28,\N,Likely benign,\N,missense_variant,0.024,\N,\N,OTOA
390392,16:21771844:G>A,NM_144672.3:c.3403G>A,NP_653273.3:p.Ala1135Thr,28/28,\N,Likely benign,\N,missense_variant,0.166,\N,\N,OTOA
390393,16:21771858:G>A,NM_144672.3:c.3417G>A,NP_653273.3:p.Trp1139Ter,28/28,\N,Unknown significance,\N,stop_gained,34,0.00022748,EVS_AA_AF,OTOA
390394,16:21771869:G>A,NM_144672.3:c.*8G>A,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,3.704,\N,\N,OTOA
390395,16:21771871:G>A,NM_144672.3:c.*10G>A,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,2.501,0.001,1KG_EUR_AF,OTOA
390396,16:21771872:C>G,NM_144672.3:c.*11C>G,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,0.96,\N,\N,OTOA
390397,16:21771872:C>T,NM_144672.3:c.*11C>T,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,1.699,\N,\N,OTOA
390398,16:21771873:G>A,NM_144672.3:c.*12G>A,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,1.637,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
390399,16:21771874:C>T,NM_144672.3:c.*13C>T,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,3.827,\N,\N,OTOA
390400,16:21771877:C>T,NM_144672.3:c.*16C>T,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,2.319,\N,\N,OTOA
390401,16:21771878:G>A,NM_144672.3:c.*17G>A,\N,28/28,\N,Benign,\N,3_prime_UTR_variant,3.286,0.006,1KG_EUR_AF,OTOA
390402,16:21771879:T>C,NM_144672.3:c.*18T>C,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,2.206,\N,\N,OTOA
390403,16:21771896:C>A,NM_144672.3:c.*35C>A,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,6.879,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
390404,16:21771897:A>C,NM_144672.3:c.*36A>C,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,5.636,\N,\N,OTOA
390405,16:21771899:C>T,NM_144672.3:c.*38C>T,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,6.147,0.000017854,EXAC_NFE_AF,OTOA
390406,16:21771908:A>G,NM_144672.3:c.*47A>G,\N,28/28,\N,Benign,\N,3_prime_UTR_variant,3.765,0.4861,1KG_EAS_AF,OTOA
390407,16:21771910:G>T,NM_144672.3:c.*49G>T,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,0.771,0.00010929,EXAC_AMR_AF,OTOA
390408,16:21771948:C>T,NM_144672.3:c.*87C>T,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,2.449,0.001,1KG_SAS_AF,OTOA
390409,16:21771961:C>A,NM_144672.3:c.*100C>A,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,3.995,0.001,1KG_EAS_AF,OTOA
390410,16:21771971:G>C,NM_144672.3:c.*110G>C,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,2.425,0.001,1KG_EAS_AF,OTOA
390411,16:21771976:G>A,NM_144672.3:c.*115G>A,\N,28/28,\N,Benign,\N,3_prime_UTR_variant,6.056,0.009375,OTO_US_AF,OTOA
390412,16:21771992:T>C,NM_144672.3:c.*131T>C,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,0.099,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
390413,16:21771999:T>G,NM_144672.3:c.*138T>G,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,4.221,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,OTOA
390414,16:21772008:A>C,NM_144672.3:c.*147A>C,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,0.779,\N,\N,OTOA
390415,16:21772013:A>C,NM_144672.3:c.*152A>C,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,0.846,0.001,1KG_EUR_AF,OTOA
390416,16:21772024:A>C,NM_144672.3:c.*163A>C,\N,28/28,\N,Unknown significance,\N,3_prime_UTR_variant,7.326,0.001,1KG_SAS_AF,OTO