id,variation,pos,vep_feature,vep_hgvs_c,vep_hgvs_p,vep_protein_pos,vep_exon,vep_intron,final_pathogenicity,final_disease,vep_consequence,vep_impact,dbnsfp_interpro_domain,vep_motif_name,vep_cadd_phred,overall_max_maf,overall_max_maf_source,gene
418362,19:46268084:G>A,46268084,NM_175875.4,NM_175875.4:c.*675C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,16.75,\N,\N,SIX5
418363,19:46268094:G>A,46268094,NM_175875.4,NM_175875.4:c.*665C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,15.43,0.001,1KG_SAS_AF,SIX5
418364,19:46268136:G>A,46268136,NM_175875.4,NM_175875.4:c.*623C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,7.472,\N,\N,SIX5
418365,19:46268145:G>A,46268145,NM_175875.4,NM_175875.4:c.*614C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,10.5,\N,\N,SIX5
418366,19:46268146:C>T,46268146,NM_175875.4,NM_175875.4:c.*613G>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,11.68,0.0008,1KG_AFR_AF,SIX5
418367,19:46268147:C>T,46268147,NM_175875.4,NM_175875.4:c.*612G>A,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,12.26,0.0144,1KG_AFR_AF,SIX5
418368,19:46268157:G>GCCCCC,46268157,NM_175875.4,NM_175875.4:c.*601_*602insGGGGG,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,\N,\N,\N,SIX5
418369,19:46268159:GGGA>G,46268159,NM_175875.4,NM_175875.4:c.*597_*599del,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,\N,\N,\N,SIX5
418370,19:46268170:G>A,46268170,NM_175875.4,NM_175875.4:c.*589C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,19.93,0.001,1KG_SAS_AF,SIX5
418371,19:46268185:T>C,46268185,NM_175875.4,NM_175875.4:c.*574A>G,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,5.047,\N,\N,SIX5
418372,19:46268251:AC>A,46268251,NM_175875.4,NM_175875.4:c.*507del,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,0.092,\N,\N,SIX5
418373,19:46268264:G>C,46268264,NM_175875.4,NM_175875.4:c.*495C>G,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,1.324,0.0015,1KG_AFR_AF,SIX5
418374,19:46268296:G>A,46268296,NM_175875.4,NM_175875.4:c.*463C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,5.84,0.0014,1KG_AMR_AF,SIX5
418375,19:46268307:G>C,46268307,NM_175875.4,NM_175875.4:c.*452C>G,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,0.163,0.002,1KG_EAS_AF,SIX5
418376,19:46268364:C>T,46268364,NM_175875.4,NM_175875.4:c.*395G>A,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,7.021,0.0068,1KG_AFR_AF,SIX5
418377,19:46268371:G>T,46268371,NM_175875.4,NM_175875.4:c.*388C>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,8.551,0.0029,1KG_AMR_AF,SIX5
418378,19:46268377:AAT>A,46268377,NM_175875.4,NM_175875.4:c.*380_*381del,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,\N,\N,\N,SIX5
418379,19:46268408:C>T,46268408,NM_175875.4,NM_175875.4:c.*351G>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,4.061,\N,\N,SIX5
418380,19:46268409:T>C,46268409,NM_175875.4,NM_175875.4:c.*350A>G,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,1.847,0.001,1KG_EAS_AF,SIX5
418381,19:46268417:C>T,46268417,NM_175875.4,NM_175875.4:c.*342G>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,3.346,\N,\N,SIX5
418382,19:46268426:C>T,46268426,NM_175875.4,NM_175875.4:c.*333G>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,6.059,\N,\N,SIX5
418383,19:46268427:G>A,46268427,NM_175875.4,NM_175875.4:c.*332C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,2.411,0.001,1KG_SAS_AF,SIX5
418384,19:46268428:G>A,46268428,NM_175875.4,NM_175875.4:c.*331C>T,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,6.965,0.0885,1KG_AFR_AF,SIX5
418385,19:46268453:C>T,46268453,NM_175875.4,NM_175875.4:c.*306G>A,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,10.83,0.0741,1KG_AFR_AF,SIX5
418386,19:46268481:C>A,46268481,NM_175875.4,NM_175875.4:c.*278G>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,12.42,0.003,1KG_EAS_AF,SIX5
418387,19:46268509:C>T,46268509,NM_175875.4,NM_175875.4:c.*250G>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,2.081,0.001,1KG_EAS_AF,SIX5
418388,19:46268510:G>A,46268510,NM_175875.4,NM_175875.4:c.*249C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,3.032,\N,\N,SIX5
418389,19:46268520:G>T,46268520,NM_175875.4,NM_175875.4:c.*239C>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,2.698,\N,\N,SIX5
418390,19:46268544:A>G,46268544,NM_175875.4,NM_175875.4:c.*215T>C,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,14.26,0.0061,1KG_AFR_AF,SIX5
418391,19:46268545:C>G,46268545,NM_175875.4,NM_175875.4:c.*214G>C,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,13.19,0.001,1KG_EAS_AF,SIX5
418392,19:46268547:G>A,46268547,NM_175875.4,NM_175875.4:c.*212C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,12.47,0.001,1KG_SAS_AF,SIX5
418393,19:46268582:G>T,46268582,NM_175875.4,NM_175875.4:c.*177C>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,2.176,0.0015,1KG_AFR_AF,SIX5
418394,19:46268598:G>C,46268598,NM_175875.4,NM_175875.4:c.*161C>G,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,0.975,0.002,1KG_EUR_AF,SIX5
418395,19:46268628:G>A,46268628,NM_175875.4,NM_175875.4:c.*131C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,6.3,\N,\N,SIX5
418396,19:46268652:G>A,46268652,NM_175875.4,NM_175875.4:c.*107C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,4.276,0.0008,1KG_AFR_AF,SIX5
418397,19:46268654:G>A,46268654,NM_175875.4,NM_175875.4:c.*105C>T,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,4.225,0.0215,1KG_SAS_AF,SIX5
418398,19:46268671:G>A,46268671,NM_175875.4,NM_175875.4:c.*88C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,8.68,0.001,1KG_EUR_AF,SIX5
418399,19:46268672:C>T,46268672,NM_175875.4,NM_175875.4:c.*87G>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,8.411,0.001,1KG_EUR_AF,SIX5
418400,19:46268677:G>A,46268677,NM_175875.4,NM_175875.4:c.*82C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,5.925,0.001,1KG_EAS_AF,SIX5
418401,19:46268690:TC>T,46268690,NM_175875.4,NM_175875.4:c.*68del,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,5.759,0.0091,1KG_AFR_AF,SIX5
418402,19:46268710:C>T,46268710,NM_175875.4,NM_175875.4:c.*49G>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,6.968,\N,\N,SIX5
418403,19:46268712:T>C,46268712,NM_175875.4,NM_175875.4:c.*47A>G,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,4.771,0.0008,1KG_AFR_AF,SIX5
418404,19:46268714:C>A,46268714,NM_175875.4,NM_175875.4:c.*45G>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,5.936,0.0000605694,EXAC_SAS_AF,SIX5
418405,19:46268714:C>T,46268714,NM_175875.4,NM_175875.4:c.*45G>A,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,5.519,0.0986011,EXAC_AFR_AF,SIX5
418406,19:46268714:CG>TA,46268714,NM_175875.4,NM_175875.4:c.*44_*45delinsTA,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,3.776,\N,\N,SIX5
418407,19:46268715:G>A,46268715,NM_175875.4,NM_175875.4:c.*44C>T,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,2.622,0.0276807,EXAC_AFR_AF,SIX5
418408,19:46268720:C>CA,46268720,NM_175875.4,NM_175875.4:c.*38dup,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,13.99,0.000097144,EXAC_AFR_AF,SIX5
418409,19:46268722:G>A,46268722,NM_175875.4,NM_175875.4:c.*37C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,14.98,0.001,1KG_EAS_AF,SIX5
418410,19:46268727:A>G,46268727,NM_175875.4,NM_175875.4:c.*32T>C,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,13.85,0.0174,1KG_AFR_AF,SIX5
418411,19:46268732:C>A,46268732,NM_175875.4,NM_175875.4:c.*27G>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,7.239,0.0014,1KG_AMR_AF,SIX5
418412,19:46268733:G>A,46268733,NM_175875.4,NM_175875.4:c.*26C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,5.985,0.001,1KG_SAS_AF,SIX5
418413,19:46268734:G>A,46268734,NM_175875.4,NM_175875.4:c.*25C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,5.833,0.000116306,EVS_EA_AF,SIX5
418414,19:46268745:G>A,46268745,NM_175875.4,NM_175875.4:c.*14C>T,\N,\N,3/3,\N,Benign,\N,3_prime_UTR_variant,MODIFIER,\N,\N,0.866,0.005,1KG_EAS_AF,SIX5
418415,19:46268752:C>T,46268752,NM_175875.4,NM_175875.4:c.*7G>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,0.97,0.0000969744,EXAC_AFR_AF,SIX5
418416,19:46268754:C>T,46268754,NM_175875.4,NM_175875.4:c.*5G>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,11.19,0.000060562,EXAC_SAS_AF,SIX5
418417,19:46268756:G>A,46268756,NM_175875.4,NM_175875.4:c.*3C>T,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,16.39,0.000151194,EXAC_FIN_AF,SIX5
418418,19:46268756:G>T,46268756,NM_175875.4,NM_175875.4:c.*3C>A,\N,\N,3/3,\N,Unknown significance,\N,3_prime_UTR_variant,MODIFIER,\N,\N,15.28,0.0000969744,EXAC_AFR_AF,SIX5
418419,19:46268763:A>G,46268763,NM_175875.4,NM_175875.4:c.2216T>C,NP_787071.2:p.Leu739Pro,739,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26.9,0.000060562,EXAC_SAS_AF,SIX5
418420,19:46268764:G>A,46268764,NM_175875.4,NM_175875.4:c.2215C>T,NP_787071.2:p.Leu739=,739,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.698,0.000453926,EVS_AA_AF,SIX5
418421,19:46268764:G>T,46268764,NM_175875.4,NM_175875.4:c.2215C>A,NP_787071.2:p.Leu739Met,739,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.8,0.000116036,EXAC_EAS_AF,SIX5
418422,19:46268767:C>G,46268767,NM_175875.4,NM_175875.4:c.2212G>C,NP_787071.2:p.Glu738Gln,738,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,22.2,0.000604778,EXAC_FIN_AF,SIX5
418423,19:46268771:G>A,46268771,NM_175875.4,NM_175875.4:c.2208C>T,NP_787071.2:p.Pro736=,736,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.967,0.000060562,EXAC_SAS_AF,SIX5
418424,19:46268779:C>T,46268779,NM_175875.4,NM_175875.4:c.2200G>A,NP_787071.2:p.Glu734Lys,734,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26,0.000015093,EXAC_NFE_AF,SIX5
418425,19:46268786:C>G,46268786,NM_175875.4,NM_175875.4:c.2193G>C,NP_787071.2:p.Val731=,731,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.36,0.000015093,EXAC_NFE_AF,SIX5
418426,19:46268787:A>G,46268787,NM_175875.4,NM_175875.4:c.2192T>C,NP_787071.2:p.Val731Ala,731,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26.2,\N,\N,SIX5
418427,19:46268789:C>T,46268789,NM_175875.4,NM_175875.4:c.2190G>A,NP_787071.2:p.Ser730=,730,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,16.42,0.000464145,EXAC_EAS_AF,SIX5
418428,19:46268790:G>A,46268790,NM_175875.4,NM_175875.4:c.2189C>T,NP_787071.2:p.Ser730Leu,730,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,33,0.000120773,EXAC_NFE_AF,SIX5
418429,19:46268797:G>A,46268797,NM_175875.4,NM_175875.4:c.2182C>T,NP_787071.2:p.Leu728Phe,728,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26.2,0.0000150975,EXAC_NFE_AF,SIX5
418430,19:46268806:G>A,46268806,NM_175875.4,NM_175875.4:c.2173C>T,NP_787071.2:p.Leu725=,725,3/3,\N,Benign,\N,synonymous_variant,LOW,\N,\N,10.12,0.0136,1KG_AFR_AF,SIX5
418431,19:46268814:G>A,46268814,NM_175875.4,NM_175875.4:c.2165C>T,NP_787071.2:p.Ala722Val,722,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,20.3,0.000116009,EXAC_EAS_AF,SIX5
418432,19:46268818:C>T,46268818,NM_175875.4,NM_175875.4:c.2161G>A,NP_787071.2:p.Glu721Lys,721,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26.5,0.000060562,EXAC_SAS_AF,SIX5
418433,19:46268828:C>G,46268828,NM_175875.4,NM_175875.4:c.2151G>C,NP_787071.2:p.Gly717=,717,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.947,0.0000151254,EXAC_NFE_AF,SIX5
418434,19:46268833:C>T,46268833,NM_175875.4,NM_175875.4:c.2146G>A,NP_787071.2:p.Glu716Lys,716,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.6,0.000151194,EXAC_FIN_AF,SIX5
418435,19:46268834:G>A,46268834,NM_175875.4,NM_175875.4:c.2145C>T,NP_787071.2:p.Asp715=,715,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,1.246,0.000116063,EXAC_EAS_AF,SIX5
418436,19:46268849:T>C,46268849,NM_175875.4,NM_175875.4:c.2130A>G,NP_787071.2:p.Ala710=,710,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,4.375,0.000116117,EXAC_EAS_AF,SIX5
418437,19:46268852:G>A,46268852,NM_175875.4,NM_175875.4:c.2127C>T,NP_787071.2:p.Thr709=,709,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.48,0.00111857,EXAC_OTH_AF,SIX5
418438,19:46268854:T>G,46268854,NM_175875.4,NM_175875.4:c.2125A>C,NP_787071.2:p.Thr709Pro,709,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,14.97,0.0000605767,EXAC_SAS_AF,SIX5
418439,19:46268861:C>T,46268861,NM_175875.4,NM_175875.4:c.2118G>A,NP_787071.2:p.Leu706=,706,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.06,0.0000152105,EXAC_NFE_AF,SIX5
418440,19:46268863:G>A,46268863,NM_175875.4,NM_175875.4:c.2116C>T,NP_787071.2:p.Leu706=,706,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.183,0.000060584,EXAC_SAS_AF,SIX5
418441,19:46268864:G>A,46268864,NM_175875.4,NM_175875.4:c.2115C>T,NP_787071.2:p.Leu705=,705,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.369,0.000116279,EVS_EA_AF,SIX5
418442,19:46268867:C>T,46268867,NM_175875.4,NM_175875.4:c.2112G>A,NP_787071.2:p.Leu704=,704,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.71,0.000302572,EXAC_FIN_AF,SIX5
418443,19:46268872:C>T,46268872,NM_175875.4,NM_175875.4:c.2107G>A,NP_787071.2:p.Gly703Arg,703,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26,0.0000152226,EXAC_NFE_AF,SIX5
418444,19:46268873:C>CT,46268873,NM_175875.4,NM_175875.4:c.2105dup,NP_787071.2:p.Leu704AlafsTer10,702,3/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,\N,\N,\N,SIX5
418445,19:46268873:C>G,46268873,NM_175875.4,NM_175875.4:c.2106G>C,NP_787071.2:p.Glu702Asp,702,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,14.9,0.0000152207,EXAC_NFE_AF,SIX5
418446,19:46268881:C>T,46268881,NM_175875.4,NM_175875.4:c.2098G>A,NP_787071.2:p.Asp700Asn,700,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.9,0.000137061,EXAC_NFE_AF,SIX5
418447,19:46268882:G>A,46268882,NM_175875.4,NM_175875.4:c.2097C>T,NP_787071.2:p.Pro699=,699,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.04,0.00147212,EXAC_AMR_AF,SIX5
418448,19:46268882:G>C,46268882,NM_175875.4,NM_175875.4:c.2097C>G,NP_787071.2:p.Pro699=,699,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.214,0.0000865951,EXAC_AMR_AF,SIX5
418449,19:46268885:G>T,46268885,NM_175875.4,NM_175875.4:c.2094C>A,NP_787071.2:p.Asp698Glu,698,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,15.96,0.0000605914,EXAC_SAS_AF,SIX5
418450,19:46268888:T>C,46268888,NM_175875.4,NM_175875.4:c.2091A>G,NP_787071.2:p.Pro697=,697,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.341,0.000116117,EXAC_EAS_AF,SIX5
418451,19:46268891:C>T,46268891,NM_175875.4,NM_175875.4:c.2088G>A,NP_787071.2:p.Leu696=,696,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.48,0.000226963,EVS_AA_AF,SIX5
418452,19:46268902:C>T,46268902,NM_175875.4,NM_175875.4:c.2077G>A,NP_787071.2:p.Val693Met,693,3/3,\N,Benign,\N,missense_variant,MODERATE,\N,\N,24.8,0.363689,EVS_EA_AF,SIX5
418453,19:46268903:G>A,46268903,NM_175875.4,NM_175875.4:c.2076C>T,NP_787071.2:p.Thr692=,692,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.896,0.00068089,EVS_AA_AF,SIX5
418454,19:46268903:G>C,46268903,NM_175875.4,NM_175875.4:c.2076C>G,NP_787071.2:p.Thr692=,692,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,3.176,0.00111359,EXAC_OTH_AF,SIX5
418455,19:46268905:T>C,46268905,NM_175875.4,NM_175875.4:c.2074A>G,NP_787071.2:p.Thr692Ala,692,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.014,0.0000605914,EXAC_SAS_AF,SIX5
418456,19:46268911:G>A,46268911,NM_175875.4,NM_175875.4:c.2068C>T,NP_787071.2:p.Pro690Ser,690,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.776,0.000015256,EXAC_NFE_AF,SIX5
418457,19:46268913:G>A,46268913,NM_175875.4,NM_175875.4:c.2066C>T,NP_787071.2:p.Ala689Val,689,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,6.453,0.001,1KG_SAS_AF,SIX5
418458,19:46268917:G>C,46268917,NM_175875.4,NM_175875.4:c.2062C>G,NP_787071.2:p.Gln688Glu,688,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,8.684,0.0000610557,EXAC_NFE_AF,SIX5
418459,19:46268920:T>A,46268920,NM_175875.4,NM_175875.4:c.2059A>T,NP_787071.2:p.Thr687Ser,687,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.226,\N,\N,SIX5
418460,19:46268925:A>G,46268925,NM_175875.4,NM_175875.4:c.2054T>C,NP_787071.2:p.Leu685Pro,685,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26.5,0.000101937,EXAC_AFR_AF,SIX5
418461,19:46268926:G>A,46268926,NM_175875.4,NM_175875.4:c.2053C>T,NP_787071.2:p.Leu685=,685,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.364,0.000519841,EXAC_AMR_AF,SIX5
418462,19:46268927:C>T,46268927,NM_175875.4,NM_175875.4:c.2052G>A,NP_787071.2:p.Gly684=,684,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.83,0.000116279,EVS_EA_AF,SIX5
418463,19:46268929:C>T,46268929,NM_175875.4,NM_175875.4:c.2050G>A,NP_787071.2:p.Gly684Arg,684,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,28.8,0.0000152849,EXAC_NFE_AF,SIX5
418464,19:46268930:C>T,46268930,NM_175875.4,NM_175875.4:c.2049G>A,NP_787071.2:p.Lys683=,683,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.74,0.000116252,EXAC_EAS_AF,SIX5
418465,19:46268934:T>C,46268934,NM_175875.4,NM_175875.4:c.2045A>G,NP_787071.2:p.Glu682Gly,682,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,23.5,0.00109064,EXAC_SAS_AF,SIX5
418466,19:46268936:C>T,46268936,NM_175875.4,NM_175875.4:c.2043G>A,NP_787071.2:p.Ala681=,681,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.14,0.000226963,EVS_AA_AF,SIX5
418467,19:46268937:G>A,46268937,NM_175875.4,NM_175875.4:c.2042C>T,NP_787071.2:p.Ala681Val,681,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,3.926,\N,\N,SIX5
418468,19:46268941:C>T,46268941,NM_175875.4,NM_175875.4:c.2038G>A,NP_787071.2:p.Glu680Lys,680,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,22.3,\N,\N,SIX5
418469,19:46268954:T>C,46268954,NM_175875.4,NM_175875.4:c.2025A>G,NP_787071.2:p.Thr675=,675,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.164,0.000151653,EXAC_FIN_AF,SIX5
418470,19:46268962:C>T,46268962,NM_175875.4,NM_175875.4:c.2017G>A,NP_787071.2:p.Ala673Thr,673,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,2.95,0.000116496,EXAC_EAS_AF,SIX5
418471,19:46268963:G>A,46268963,NM_175875.4,NM_175875.4:c.2016C>T,NP_787071.2:p.Ser672=,672,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.841,0.0011236,EXAC_OTH_AF,SIX5
418472,19:46268964:C>T,46268964,NM_175875.4,NM_175875.4:c.2015G>A,NP_787071.2:p.Ser672Asn,672,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,16.65,0.0000307059,EXAC_NFE_AF,SIX5
418473,19:46268965:T>C,46268965,NM_175875.4,NM_175875.4:c.2014A>G,NP_787071.2:p.Ser672Gly,672,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,15.69,0.000151745,EXAC_FIN_AF,SIX5
418474,19:46268977:C>T,46268977,NM_175875.4,NM_175875.4:c.2002G>A,NP_787071.2:p.Gly668Arg,668,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,27.1,0.000232558,EVS_EA_AF,SIX5
418475,19:46268984:C>G,46268984,NM_175875.4,NM_175875.4:c.1995G>C,NP_787071.2:p.Trp665Cys,665,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26.9,0.0000154235,EXAC_NFE_AF,SIX5
418476,19:46268985:C>A,46268985,NM_175875.4,NM_175875.4:c.1994G>T,NP_787071.2:p.Trp665Leu,665,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.7,0.0008,1KG_AFR_AF,SIX5
418477,19:46268986:A>G,46268986,NM_175875.4,NM_175875.4:c.1993T>C,NP_787071.2:p.Trp665Arg,665,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.3,0.0000605987,EXAC_SAS_AF,SIX5
418478,19:46268987:G>A,46268987,NM_175875.4,NM_175875.4:c.1992C>T,NP_787071.2:p.Val664=,664,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.401,0.0000867604,EXAC_AMR_AF,SIX5
418479,19:46268989:C>T,46268989,NM_175875.4,NM_175875.4:c.1990G>A,NP_787071.2:p.Val664Ile,664,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,6.109,\N,\N,SIX5
418480,19:46268993:C>T,46268993,NM_175875.4,NM_175875.4:c.1986G>A,NP_787071.2:p.Val662=,662,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,6.842,0.0000155246,EXAC_NFE_AF,SIX5
418481,19:46268995:C>T,46268995,NM_175875.4,NM_175875.4:c.1984G>A,NP_787071.2:p.Val662Met,662,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,14.35,0.0000868206,EXAC_AMR_AF,SIX5
418482,19:46268996:G>A,46268996,NM_175875.4,NM_175875.4:c.1983C>T,NP_787071.2:p.Ala661=,661,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.137,0.000116306,EVS_EA_AF,SIX5
418483,19:46268996:G>GGCC,46268996,NM_175875.4,NM_175875.4:c.1980_1982dup,NP_787071.2:p.Ala661dup,661,3/3,\N,Unknown significance,\N,inframe_insertion,MODERATE,\N,\N,4.626,0.000234247,EXAC_EAS_AF,SIX5
418484,19:46268997:G>A,46268997,NM_175875.4,NM_175875.4:c.1982C>T,NP_787071.2:p.Ala661Val,661,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,11.96,0.0000606208,EXAC_SAS_AF,SIX5
418485,19:46268999:C>T,46268999,NM_175875.4,NM_175875.4:c.1980G>A,NP_787071.2:p.Ala660=,660,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.28,0.001,1KG_SAS_AF,SIX5
418486,19:46269000:G>A,46269000,NM_175875.4,NM_175875.4:c.1979C>T,NP_787071.2:p.Ala660Val,660,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,21.2,0.000232666,EVS_EA_AF,SIX5
418487,19:46269000:G>T,46269000,NM_175875.4,NM_175875.4:c.1979C>A,NP_787071.2:p.Ala660Glu,660,3/3,\N,Benign,\N,missense_variant,MODERATE,\N,\N,22.6,0.0061,1KG_SAS_AF,SIX5
418488,19:46269001:C>T,46269001,NM_175875.4,NM_175875.4:c.1978G>A,NP_787071.2:p.Ala660Thr,660,3/3,\N,Benign,\N,missense_variant,MODERATE,\N,\N,13.67,0.0082,1KG_SAS_AF,SIX5
418489,19:46269002:G>A,46269002,NM_175875.4,NM_175875.4:c.1977C>T,NP_787071.2:p.Pro659=,659,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.737,0.0000155778,EXAC_NFE_AF,SIX5
418490,19:46269003:G>C,46269003,NM_175875.4,NM_175875.4:c.1976C>G,NP_787071.2:p.Pro659Arg,659,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,18.1,0.0000467435,EXAC_NFE_AF,SIX5
418491,19:46269004:G>C,46269004,NM_175875.4,NM_175875.4:c.1975C>G,NP_787071.2:p.Pro659Ala,659,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,11.86,0.000015586,EXAC_NFE_AF,SIX5
418492,19:46269006:GACA>G,46269006,NM_175875.4,NM_175875.4:c.1970_1972del,NP_787071.2:p.Leu657del,657-658,3/3,\N,Unknown significance,\N,inframe_deletion,MODERATE,\N,\N,18.8,0.0000468165,EXAC_NFE_AF,SIX5
418493,19:46269007:A>G,46269007,NM_175875.4,NM_175875.4:c.1972T>C,NP_787071.2:p.Ser658Pro,658,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.6,\N,\N,SIX5
418494,19:46269010:A>T,46269010,NM_175875.4,NM_175875.4:c.1969T>A,NP_787071.2:p.Leu657Met,657,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,17.98,0.0000869112,EXAC_AMR_AF,SIX5
418495,19:46269013:T>G,46269013,NM_175875.4,NM_175875.4:c.1966A>C,NP_787071.2:p.Met656Leu,656,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,5.642,0.000117261,EXAC_EAS_AF,SIX5
418496,19:46269015:AG>A,46269015,NM_175875.4,NM_175875.4:c.1963del,NP_787071.2:p.Leu655Ter,655,3/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,32,0.0000606575,EXAC_SAS_AF,SIX5
418497,19:46269016:G>A,46269016,NM_175875.4,NM_175875.4:c.1963C>T,NP_787071.2:p.Leu655=,655,3/3,\N,Benign,\N,synonymous_variant,LOW,\N,\N,8.862,0.0144,1KG_AFR_AF,SIX5
418498,19:46269017:C>T,46269017,NM_175875.4,NM_175875.4:c.1962G>A,NP_787071.2:p.Gly654=,654,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.29,\N,\N,SIX5
418499,19:46269018:C>T,46269018,NM_175875.4,NM_175875.4:c.1961G>A,NP_787071.2:p.Gly654Glu,654,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.3,0.000227583,EVS_AA_AF,SIX5
418500,19:46269020:C>T,46269020,NM_175875.4,NM_175875.4:c.1959G>A,NP_787071.2:p.Glu653=,653,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.59,0.000111682,EXAC_AFR_AF,SIX5
418501,19:46269024:G>A,46269024,NM_175875.4,NM_175875.4:c.1955C>T,NP_787071.2:p.Pro652Leu,652,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,6.29,0.0000315627,EXAC_NFE_AF,SIX5
418502,19:46269029:G>A,46269029,NM_175875.4,NM_175875.4:c.1950C>T,NP_787071.2:p.Pro650=,650,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.916,0.000116768,EVS_EA_AF,SIX5
418503,19:46269029:G>C,46269029,NM_175875.4,NM_175875.4:c.1950C>G,NP_787071.2:p.Pro650=,650,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.115,0.0000607165,EXAC_SAS_AF,SIX5
418504,19:46269031:G>T,46269031,NM_175875.4,NM_175875.4:c.1948C>A,NP_787071.2:p.Pro650Thr,650,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,8.584,0.0008,1KG_AFR_AF,SIX5
418505,19:46269032:C>G,46269032,NM_175875.4,NM_175875.4:c.1947G>C,NP_787071.2:p.Ala649=,649,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.354,0.0000158288,EXAC_NFE_AF,SIX5
418506,19:46269032:C>T,46269032,NM_175875.4,NM_175875.4:c.1947G>A,NP_787071.2:p.Ala649=,649,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.29,0.000087184,EXAC_AMR_AF,SIX5
418507,19:46269034:C>A,46269034,NM_175875.4,NM_175875.4:c.1945G>T,NP_787071.2:p.Ala649Ser,649,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,14.78,0.0000316746,EXAC_NFE_AF,SIX5
418508,19:46269035:C>T,46269035,NM_175875.4,NM_175875.4:c.1944G>A,NP_787071.2:p.Pro648=,648,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.02,0.000364431,EXAC_SAS_AF,SIX5
418509,19:46269036:G>A,46269036,NM_175875.4,NM_175875.4:c.1943C>T,NP_787071.2:p.Pro648Leu,648,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,13.07,0.00114155,EXAC_AFR_AF,SIX5
418510,19:46269036:G>C,46269036,NM_175875.4,NM_175875.4:c.1943C>G,NP_787071.2:p.Pro648Arg,648,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,9.671,0.000174429,EXAC_AMR_AF,SIX5
418511,19:46269042:T>C,46269042,NM_175875.4,NM_175875.4:c.1937A>G,NP_787071.2:p.Asn646Ser,646,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.001,0.0000158629,EXAC_NFE_AF,SIX5
418512,19:46269043:T>G,46269043,NM_175875.4,NM_175875.4:c.1936A>C,NP_787071.2:p.Asn646His,646,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,6.305,\N,\N,SIX5
418513,19:46269043:T>TGGGCAGGAGGCCAGGGGAGTC,46269043,NM_175875.4,NM_175875.4:c.1915_1935dup,NP_787071.2:p.Asp639_Pro645dup,645-646,3/3,\N,Unknown significance,\N,inframe_insertion,MODERATE,\N,\N,0.035,\N,\N,SIX5
418514,19:46269045:G>C,46269045,NM_175875.4,NM_175875.4:c.1934C>G,NP_787071.2:p.Pro645Arg,645,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,6.149,0.000486145,EXAC_SAS_AF,SIX5
418515,19:46269046:G>A,46269046,NM_175875.4,NM_175875.4:c.1933C>T,NP_787071.2:p.Pro645Ser,645,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.004,0.001,1KG_EUR_AF,SIX5
418516,19:46269052:G>C,46269052,NM_175875.4,NM_175875.4:c.1927C>G,NP_787071.2:p.Leu643Val,643,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,10.93,0.000115207,EXAC_AFR_AF,SIX5
418517,19:46269054:CCAGGGGAGT>C,46269054,NM_175875.4,NM_175875.4:c.1916_1924del,NP_787071.2:p.Asp639_Pro641del,639-642,3/3,\N,Unknown significance,\N,inframe_deletion,MODERATE,\N,\N,18.31,\N,\N,SIX5
418518,19:46269055:C>T,46269055,NM_175875.4,NM_175875.4:c.1924G>A,NP_787071.2:p.Gly642Ser,642,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,3.381,\N,\N,SIX5
418519,19:46269056:A>G,46269056,NM_175875.4,NM_175875.4:c.1923T>C,NP_787071.2:p.Pro641=,641,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.079,0.000115982,EXAC_AFR_AF,SIX5
418520,19:46269059:G>A,46269059,NM_175875.4,NM_175875.4:c.1920C>T,NP_787071.2:p.Ser640=,640,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.124,0.000231803,EXAC_AFR_AF,SIX5
418521,19:46269064:CAGGGGAGA>C,46269064,NM_175875.4,NM_175875.4:c.1907_1914del,NP_787071.2:p.Phe636Ter,636-638,3/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,35,0.0000159995,EXAC_NFE_AF,SIX5
418522,19:46269069:GAGA>G,46269069,NM_175875.4,NM_175875.4:c.1907_1909del,NP_787071.2:p.Phe636del,636-637,3/3,\N,Unknown significance,\N,inframe_deletion,MODERATE,\N,\N,13.98,0.0000160375,EXAC_NFE_AF,SIX5
418523,19:46269069:G>A,46269069,NM_175875.4,NM_175875.4:c.1910C>T,NP_787071.2:p.Ser637Phe,637,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.7,0.000425998,EXAC_SAS_AF,SIX5
418524,19:46269069:G>C,46269069,NM_175875.4,NM_175875.4:c.1910C>G,NP_787071.2:p.Ser637Cys,637,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.6,0.0000160375,EXAC_NFE_AF,SIX5
418525,19:46269075:G>A,46269075,NM_175875.4,NM_175875.4:c.1904C>T,NP_787071.2:p.Pro635Leu,635,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.9,0.0000878272,EXAC_AMR_AF,SIX5
418526,19:46269076:G>A,46269076,NM_175875.4,NM_175875.4:c.1903C>T,NP_787071.2:p.Pro635Ser,635,3/3,\N,Benign,\N,missense_variant,MODERATE,\N,\N,9.424,0.684472,EXAC_AMR_AF,SIX5
418527,19:46269077:C>A,46269077,NM_175875.4,NM_175875.4:c.1902G>T,NP_787071.2:p.Leu634=,634,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.1,0.0000164739,EXAC_NFE_AF,SIX5
418528,19:46269085:T>G,46269085,NM_175875.4,NM_175875.4:c.1894A>C,NP_787071.2:p.Thr632Pro,632,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.065,\N,\N,SIX5
418529,19:46269097:T>C,46269097,NM_175875.4,NM_175875.4:c.1882A>G,NP_787071.2:p.Thr628Ala,628,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.002,\N,\N,SIX5
418530,19:46269103:C>T,46269103,NM_175875.4,NM_175875.4:c.1876G>A,NP_787071.2:p.Ala626Thr,626,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.017,0.000141443,EXAC_EAS_AF,SIX5
418531,19:46269104:G>A,46269104,NM_175875.4,NM_175875.4:c.1875C>T,NP_787071.2:p.Ala625=,625,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.953,0.000148633,EXAC_AFR_AF,SIX5
418532,19:46269106:C>T,46269106,NM_175875.4,NM_175875.4:c.1873G>A,NP_787071.2:p.Ala625Thr,625,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.272,0.00345657,EXAC_AFR_AF,SIX5
418533,19:46269107:G>A,46269107,NM_175875.4,NM_175875.4:c.1872C>T,NP_787071.2:p.Pro624=,624,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,4.293,0.00210273,EXAC_AFR_AF,SIX5
418534,19:46269107:G>T,46269107,NM_175875.4,NM_175875.4:c.1872C>A,NP_787071.2:p.Pro624=,624,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,2.035,0.000300391,EXAC_AFR_AF,SIX5
418535,19:46269108:G>C,46269108,NM_175875.4,NM_175875.4:c.1871C>G,NP_787071.2:p.Pro624Arg,624,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,10.45,0.0000596706,EXAC_NFE_AF,SIX5
418536,19:46269112:G>C,46269112,NM_175875.4,NM_175875.4:c.1867C>G,NP_787071.2:p.Pro623Ala,623,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.02,0.001,1KG_EAS_AF,SIX5
418537,19:46269124:C>T,46269124,NM_175875.4,NM_175875.4:c.1855G>A,NP_787071.2:p.Ala619Thr,619,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.202,0.000167224,EXAC_EAS_AF,SIX5
418538,19:46269135:C>T,46269135,NM_175875.4,NM_175875.4:c.1844G>A,NP_787071.2:p.Gly615Asp,615,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.194,\N,\N,SIX5
418539,19:46269142:C>T,46269142,NM_175875.4,NM_175875.4:c.1837G>A,NP_787071.2:p.Ala613Thr,613,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.009,0.000162232,EXAC_AMR_AF,SIX5
418540,19:46269143:G>A,46269143,NM_175875.4,NM_175875.4:c.1836C>T,NP_787071.2:p.His612=,612,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.025,\N,\N,SIX5
418541,19:46269147:G>A,46269147,NM_175875.4,NM_175875.4:c.1832C>T,NP_787071.2:p.Ala611Val,611,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,5.184,0.000183688,EXAC_AFR_AF,SIX5
418542,19:46269159:G>T,46269159,NM_175875.4,NM_175875.4:c.1820C>A,NP_787071.2:p.Ala607Asp,607,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,2.686,\N,\N,SIX5
418543,19:46269162:G>A,46269162,NM_175875.4,NM_175875.4:c.1817C>T,NP_787071.2:p.Pro606Leu,606,3/3,\N,Pathogenic,Congenital anomalies of the kidney and urinary tract,missense_variant,MODERATE,\N,\N,24.5,\N,\N,SIX5
418544,19:46269168:G>A,46269168,NM_175875.4,NM_175875.4:c.1811C>T,NP_787071.2:p.Pro604Leu,604,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,19.32,\N,\N,SIX5
418545,19:46269176:C>T,46269176,NM_175875.4,NM_175875.4:c.1803G>A,NP_787071.2:p.Pro601=,601,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.595,0.001,1KG_EAS_AF,SIX5
418546,19:46269177:G>A,46269177,NM_175875.4,NM_175875.4:c.1802C>T,NP_787071.2:p.Pro601Leu,601,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,21.4,0.0000505996,EXAC_NFE_AF,SIX5
418547,19:46269180:A>AG,46269180,NM_175875.4,NM_175875.4:c.1798dup,NP_787071.2:p.Leu600ProfsTer40,600,3/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,25.4,\N,\N,SIX5
418548,19:46269183:C>T,46269183,NM_175875.4,NM_175875.4:c.1796G>A,NP_787071.2:p.Gly599Asp,599,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,11.67,0.0000939496,EXAC_SAS_AF,SIX5
418549,19:46269192:G>A,46269192,NM_175875.4,NM_175875.4:c.1787C>T,NP_787071.2:p.Pro596Leu,596,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.4,0.0003427,EXAC_AFR_AF,SIX5
418550,19:46269194:C>A,46269194,NM_175875.4,NM_175875.4:c.1785G>T,NP_787071.2:p.Val595=,595,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,4.571,0.000095584,EXAC_SAS_AF,SIX5
418551,19:46269196:C>T,46269196,NM_175875.4,NM_175875.4:c.1783G>A,NP_787071.2:p.Val595Met,595,3/3,\N,Benign,\N,missense_variant,MODERATE,\N,\N,22.7,0.0751656,EXAC_AFR_AF,SIX5
418552,19:46269197:G>A,46269197,NM_175875.4,NM_175875.4:c.1782C>T,NP_787071.2:p.Ser594=,594,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,5.037,0.000378358,EXAC_EAS_AF,SIX5
418553,19:46269197:G>C,46269197,NM_175875.4,NM_175875.4:c.1782C>G,NP_787071.2:p.Ser594=,594,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.31,0.0000951113,EXAC_SAS_AF,SIX5
418554,19:46269205:C>T,46269205,NM_175875.4,NM_175875.4:c.1774G>A,NP_787071.2:p.Ala592Thr,592,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,9.996,0.0000965997,EXAC_SAS_AF,SIX5
418555,19:46269206:C>A,46269206,NM_175875.4,NM_175875.4:c.1773G>T,NP_787071.2:p.Thr591=,591,3/3,\N,Benign,\N,synonymous_variant,LOW,\N,\N,13.79,0.0051,1KG_SAS_AF,SIX5
418556,19:46269206:C>G,46269206,NM_175875.4,NM_175875.4:c.1773G>C,NP_787071.2:p.Thr591=,591,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.203,0.000023771,EXAC_NFE_AF,SIX5
418557,19:46269206:C>T,46269206,NM_175875.4,NM_175875.4:c.1773G>A,NP_787071.2:p.Thr591=,591,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.34,0.000189825,EXAC_SAS_AF,SIX5
418558,19:46269207:G>A,46269207,NM_175875.4,NM_175875.4:c.1772C>T,NP_787071.2:p.Thr591Met,591,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,14.85,0.000160462,EXAC_AFR_AF,SIX5
418559,19:46269208:T>A,46269208,NM_175875.4,NM_175875.4:c.1771A>T,NP_787071.2:p.Thr591Ser,591,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.002,0.000358038,EXAC_EAS_AF,SIX5
418560,19:46269223:G>A,46269223,NM_175875.4,NM_175875.4:c.1756C>T,NP_787071.2:p.Pro586Ser,586,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,22.8,0.000117096,EVS_EA_AF,SIX5
418561,19:46269224:C>T,46269224,NM_175875.4,NM_175875.4:c.1755G>A,NP_787071.2:p.Leu585=,585,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.24,0.0000243345,EXAC_NFE_AF,SIX5
418562,19:46269227:GGCCA>G,46269227,NM_175875.4,NM_175875.4:c.1748_1751del,NP_787071.2:p.Leu583ProfsTer4,583-584,3/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,32,\N,\N,SIX5
418563,19:46269229:C>G,46269229,NM_175875.4,NM_175875.4:c.1750G>C,NP_787071.2:p.Ala584Pro,584,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,7.615,\N,\N,SIX5
418564,19:46269235:C>T,46269235,NM_175875.4,NM_175875.4:c.1744G>A,NP_787071.2:p.Gly582Ser,582,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.005,0.0000240385,EXAC_NFE_AF,SIX5
418565,19:46269236:G>A,46269236,NM_175875.4,NM_175875.4:c.1743C>T,NP_787071.2:p.Pro581=,581,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,1.46,0.0008,1KG_AFR_AF,SIX5
418566,19:46269239:G>A,46269239,NM_175875.4,NM_175875.4:c.1740C>T,NP_787071.2:p.Ala580=,580,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.014,0.0000982704,EXAC_SAS_AF,SIX5
418567,19:46269240:G>A,46269240,NM_175875.4,NM_175875.4:c.1739C>T,NP_787071.2:p.Ala580Val,580,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,2.136,0.000571919,EXAC_AMR_AF,SIX5
418568,19:46269241:C>T,46269241,NM_175875.4,NM_175875.4:c.1738G>A,NP_787071.2:p.Ala580Thr,580,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.666,0.000116604,EVS_EA_AF,SIX5
418569,19:46269245:C>T,46269245,NM_175875.4,NM_175875.4:c.1734G>A,NP_787071.2:p.Pro578=,578,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,2.791,0.001,1KG_EAS_AF,SIX5
418570,19:46269246:G>A,46269246,NM_175875.4,NM_175875.4:c.1733C>T,NP_787071.2:p.Pro578Leu,578,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.9,0.0000222499,EXAC_NFE_AF,SIX5
418571,19:46269248:C>T,46269248,NM_175875.4,NM_175875.4:c.1731G>A,NP_787071.2:p.Leu577=,577,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.01,\N,\N,SIX5
418572,19:46269256:G>A,46269256,NM_175875.4,NM_175875.4:c.1723C>T,NP_787071.2:p.Gln575Ter,575,3/3,\N,Unknown significance,\N,stop_gained,HIGH,\N,\N,37,0.0000208594,EXAC_NFE_AF,SIX5
418573,19:46269262:C>G,46269262,NM_175875.4,NM_175875.4:c.1717G>C,NP_787071.2:p.Val573Leu,573,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,16.88,0.00163447,EXAC_EAS_AF,SIX5
418574,19:46269262:C>T,46269262,NM_175875.4,NM_175875.4:c.1717G>A,NP_787071.2:p.Val573Ile,573,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,17.31,0.0000812018,EXAC_NFE_AF,SIX5
418575,19:46269263:G>A,46269263,NM_175875.4,NM_175875.4:c.1716C>T,NP_787071.2:p.Leu572=,572,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.853,0.00011636,EVS_EA_AF,SIX5
418576,19:46269265:G>C,46269265,NM_175875.4,NM_175875.4:c.1714C>G,NP_787071.2:p.Leu572Val,572,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23,0.001,1KG_EAS_AF,SIX5
418577,19:46269270:C>T,46269270,NM_175875.4,NM_175875.4:c.1709G>A,NP_787071.2:p.Ser570Asn,570,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,17.38,0.0000193416,EXAC_NFE_AF,SIX5
418578,19:46269280:A>G,46269280,NM_175875.4,NM_175875.4:c.1699T>C,NP_787071.2:p.Phe567Leu,567,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,18.84,0.00124378,EXAC_EAS_AF,SIX5
418579,19:46269281:G>A,46269281,NM_175875.4,NM_175875.4:c.1698C>T,NP_787071.2:p.Thr566=,566,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,6.81,0.0000368406,EXAC_NFE_AF,SIX5
418580,19:46269284:G>A,46269284,NM_175875.4,NM_175875.4:c.1695C>T,NP_787071.2:p.Ala565=,565,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,5.968,0.0000753239,EXAC_SAS_AF,SIX5
418581,19:46269286:C>G,46269286,NM_175875.4,NM_175875.4:c.1693G>C,NP_787071.2:p.Ala565Pro,565,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.7,0.0000751428,EXAC_SAS_AF,SIX5
418582,19:46269287:G>A,46269287,NM_175875.4,NM_175875.4:c.1692C>T,NP_787071.2:p.Thr564=,564,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.59,0.001,1KG_EUR_AF,SIX5
418583,19:46269289:T>C,46269289,NM_175875.4,NM_175875.4:c.1690A>G,NP_787071.2:p.Thr564Ala,564,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,22,0.000073497,EXAC_SAS_AF,SIX5
418584,19:46269292:G>A,46269292,NM_175875.4,NM_175875.4:c.1687C>T,NP_787071.2:p.Leu563Phe,563,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24,0.000124118,EXAC_NFE_AF,SIX5
418585,19:46269292:G>C,46269292,NM_175875.4,NM_175875.4:c.1687C>G,NP_787071.2:p.Leu563Val,563,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.2,0.0000725163,EXAC_SAS_AF,SIX5
418586,19:46269293:G>A,46269293,NM_175875.4,NM_175875.4:c.1686C>T,NP_787071.2:p.Ile562=,562,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.23,0.000121212,EXAC_AFR_AF,SIX5
418587,19:46269295:T>C,46269295,NM_175875.4,NM_175875.4:c.1684A>G,NP_787071.2:p.Ile562Val,562,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,3.9,0.000107342,EXAC_AMR_AF,SIX5
418588,19:46269296:G>C,46269296,NM_175875.4,NM_175875.4:c.1683C>G,NP_787071.2:p.Ile561Met,561,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,22.8,0.000071623,EXAC_SAS_AF,SIX5
418589,19:46269304:C>G,46269304,NM_175875.4,NM_175875.4:c.1675G>C,NP_787071.2:p.Gly559Arg,559,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.3,0.000227169,EVS_AA_AF,SIX5
418590,19:46269304:C>T,46269304,NM_175875.4,NM_175875.4:c.1675G>A,NP_787071.2:p.Gly559Ser,559,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.8,0.000141844,EXAC_SAS_AF,SIX5
418591,19:46269311:C>T,46269311,NM_175875.4,NM_175875.4:c.1668G>A,NP_787071.2:p.Val556=,556,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.36,0.000117619,EXAC_AFR_AF,SIX5
418592,19:46269313:G>C,46269313,NM_001288764.1,\N,\N,\N,\N,\N,Benign,\N,downstream_gene_variant,MODIFIER,\N,\N,0.088,0.9924,1KG_AFR_AF,SIX5
418593,19:46269313:G>T,46269313,NM_175875.4,NM_175875.4:c.1666C>A,NP_787071.2:p.Val556Met,556,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,11.63,0.0012285,EXAC_OTH_AF,SIX5
418594,19:46269314:G>A,46269314,NM_175875.4,NM_175875.4:c.1665C>T,NP_787071.2:p.Ala555=,555,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.946,0.000192938,EXAC_AMR_AF,SIX5
418595,19:46269319:C>T,46269319,NM_175875.4,NM_175875.4:c.1660G>A,NP_787071.2:p.Val554Met,554,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,22.6,0.000116306,EVS_EA_AF,SIX5
418596,19:46269321:C>T,46269321,NM_175875.4,NM_175875.4:c.1658G>A,NP_787071.2:p.Gly553Asp,553,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.2,0.000110084,EXAC_AFR_AF,SIX5
418597,19:46269323:C>T,46269323,NM_175875.4,NM_175875.4:c.1656G>A,NP_787071.2:p.Thr552=,552,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.31,0.00150378,EXAC_NFE_AF,SIX5
418598,19:46269324:G>A,46269324,NM_175875.4,NM_175875.4:c.1655C>T,NP_787071.2:p.Thr552Met,552,3/3,\N,Pathogenic,Branchio-oto-renal syndrome,missense_variant,MODERATE,\N,\N,26.6,0.0014,1KG_AMR_AF,SIX5
418599,19:46269324:G>T,46269324,NM_175875.4,NM_175875.4:c.1655C>A,NP_787071.2:p.Thr552Lys,552,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,27.5,0.000110717,EXAC_AFR_AF,SIX5
418600,19:46269328:C>A,46269328,NM_175875.4,NM_175875.4:c.1651G>T,NP_787071.2:p.Val551Leu,551,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,23.9,0.000135355,EXAC_SAS_AF,SIX5
418601,19:46269328:C>T,46269328,NM_175875.4,NM_175875.4:c.1651G>A,NP_787071.2:p.Val551Met,551,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.9,0.00100654,EXAC_EAS_AF,SIX5
418602,19:46269329:G>A,46269329,NM_175875.4,NM_175875.4:c.1650C>T,NP_787071.2:p.Ile550=,550,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.25,\N,\N,SIX5
418603,19:46269332:G>T,46269332,NM_175875.4,NM_175875.4:c.1647C>A,NP_787071.2:p.Pro549=,549,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.711,0.0000166118,EXAC_NFE_AF,SIX5
418604,19:46269337:T>C,46269337,NM_175875.4,NM_175875.4:c.1642A>G,NP_787071.2:p.Ser548Gly,548,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25,\N,\N,SIX5
418605,19:46269338:G>A,46269338,NM_175875.4,NM_175875.4:c.1641C>T,NP_787071.2:p.Gly547=,547,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.161,0.000111807,EXAC_AFR_AF,SIX5
418606,19:46269339:C>T,46269339,NM_175875.4,NM_175875.4:c.1640G>A,NP_787071.2:p.Gly547Asp,547,3/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,25.2,0.0000333812,EXAC_NFE_AF,SIX5
418607,19:46269340:C>G,46269340,NM_175875.4,NM_175875.4:c.1639G>C,NP_787071.2:p.Gly547Arg,547,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.7,0.0000167129,EXAC_NFE_AF,SIX5
418608,19:46269348:G>A,46269348,NM_175875.4,NM_175875.4:c.1631C>T,NP_787071.2:p.Pro544Leu,544,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.6,0.0000168611,EXAC_NFE_AF,SIX5
418609,19:46269350:G>A,46269350,NM_175875.4,NM_175875.4:c.1629C>T,NP_787071.2:p.Asn543=,543,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,4.666,0.00010008,EXAC_AMR_AF,SIX5
418610,19:46269354:G>A,46269354,NM_175875.4,NM_175875.4:c.1625C>T,NP_787071.2:p.Ala542Val,542,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,28.6,\N,\N,SIX5
418611,19:46269358:G>A,46269358,NM_175875.4,NM_175875.4:c.1621C>T,NP_787071.2:p.Leu541=,541,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.717,0.0000170433,EXAC_NFE_AF,SIX5
418612,19:46269358:G>T,46269358,NM_175875.4,NM_175875.4:c.1621C>A,NP_787071.2:p.Leu541Met,541,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.4,0.000116279,EVS_EA_AF,SIX5
418613,19:46269361:G>A,46269361,NM_175875.4,NM_175875.4:c.1618C>T,NP_787071.2:p.Leu540Phe,540,3/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24,0.000115527,EXAC_AFR_AF,SIX5
418614,19:46269362:G>A,46269362,NM_175875.4,NM_175875.4:c.1617C>T,NP_787071.2:p.Phe539=,539,3/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.33,0.000686271,EXAC_NFE_AF,SIX5
418615,19:46269378:A>G,46269378,NM_175875.4,NM_175875.4:c.1610-9T>C,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,12.97,0.000134012,EXAC_EAS_AF,SIX5
418616,19:46269382:A>C,46269382,NM_175875.4,NM_175875.4:c.1610-13T>G,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.336,0.000116279,EVS_EA_AF,SIX5
418617,19:46269384:G>A,46269384,NM_175875.4,NM_175875.4:c.1610-15C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,2.313,0.000076476,EXAC_SAS_AF,SIX5
418618,19:46269385:G>A,46269385,NM_175875.4,NM_175875.4:c.1610-16C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,1.099,0.0000768758,EXAC_SAS_AF,SIX5
418619,19:46269388:C>T,46269388,NM_175875.4,NM_175875.4:c.1610-19G>A,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,1.213,0.000234448,EXAC_SAS_AF,SIX5
418620,19:46269389:G>A,46269389,NM_175875.4,NM_175875.4:c.1610-20C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.032,\N,\N,SIX5
418621,19:46269389:G>C,46269389,NM_175875.4,NM_175875.4:c.1610-20C>G,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.006,\N,\N,SIX5
418622,19:46269392:C>T,46269392,NM_175875.4,NM_175875.4:c.1610-23G>A,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.6,0.000249004,EXAC_AFR_AF,SIX5
418623,19:46269393:G>A,46269393,NM_175875.4,NM_175875.4:c.1610-24C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.166,\N,\N,SIX5
418624,19:46269394:C>T,46269394,NM_175875.4,NM_175875.4:c.1610-25G>A,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.737,0.000698162,EVS_EA_AF,SIX5
418625,19:46269396:G>C,46269396,NM_175875.4,NM_175875.4:c.1610-27C>G,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.153,0.00011636,EVS_EA_AF,SIX5
418626,19:46269404:C>T,46269404,NM_175875.4,NM_175875.4:c.1610-35G>A,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.405,0.0000187949,EXAC_NFE_AF,SIX5
418627,19:46269412:G>A,46269412,NM_175875.4,NM_175875.4:c.1610-43C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.617,\N,\N,SIX5
418628,19:46269415:G>A,46269415,NM_175875.4,NM_175875.4:c.1610-46C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.034,0.000275482,EXAC_AFR_AF,SIX5
418629,19:46269416:G>A,46269416,NM_175875.4,NM_175875.4:c.1610-47C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.779,0.00011636,EVS_EA_AF,SIX5
418630,19:46269421:G>A,46269421,NM_175875.4,NM_175875.4:c.1610-52C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.448,0.0000600817,EXAC_NFE_AF,SIX5
418631,19:46269422:C>G,46269422,NM_175875.4,NM_175875.4:c.1610-53G>C,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.486,\N,\N,SIX5
418632,19:46269425:G>A,46269425,NM_175875.4,NM_175875.4:c.1610-56C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.004,\N,\N,SIX5
418633,19:46269432:G>A,46269432,NM_175875.4,NM_175875.4:c.1610-63C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.589,0.001,1KG_SAS_AF,SIX5
418634,19:46269435:G>A,46269435,NM_175875.4,NM_175875.4:c.1610-66C>T,\N,\N,\N,2/2,Benign,\N,intron_variant,MODIFIER,\N,\N,0.132,0.0072,1KG_SAS_AF,SIX5
418635,19:46269441:G>A,46269441,NM_175875.4,NM_175875.4:c.1610-72C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.327,\N,\N,SIX5
418636,19:46269446:G>A,46269446,NM_175875.4,NM_175875.4:c.1610-77C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.22,0.001,1KG_SAS_AF,SIX5
418637,19:46269455:C>A,46269455,NM_175875.4,NM_175875.4:c.1610-86G>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.333,0.0008,1KG_AFR_AF,SIX5
418638,19:46269472:G>A,46269472,NM_175875.4,NM_175875.4:c.1610-103C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.451,\N,\N,SIX5
418639,19:46269527:C>T,46269527,NM_175875.4,NM_175875.4:c.1609+81G>A,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,2.283,0.003,1KG_EUR_AF,SIX5
418640,19:46269545:C>G,46269545,NM_175875.4,NM_175875.4:c.1609+63G>C,\N,\N,\N,2/2,Benign,\N,intron_variant,MODIFIER,\N,\N,6.341,0.1195,1KG_AFR_AF,SIX5
418641,19:46269559:C>T,46269559,NM_175875.4,NM_175875.4:c.1609+49G>A,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.421,0.00147929,EXAC_EAS_AF,SIX5
418642,19:46269566:C>T,46269566,NM_175875.4,NM_175875.4:c.1609+42G>A,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.113,0.0015,1KG_AFR_AF,SIX5
418643,19:46269568:C>A,46269568,NM_175875.4,NM_175875.4:c.1609+40G>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.452,\N,\N,SIX5
418644,19:46269570:G>A,46269570,NM_175875.4,NM_175875.4:c.1609+38C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.095,0.00278552,EXAC_EAS_AF,SIX5
418645,19:46269578:C>T,46269578,NM_175875.4,NM_175875.4:c.1609+30G>A,\N,\N,\N,2/2,Benign,\N,intron_variant,MODIFIER,\N,\N,2.974,0.0175131,EXAC_AFR_AF,SIX5
418646,19:46269584:C>T,46269584,NM_175875.4,NM_175875.4:c.1609+24G>A,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,1.433,\N,\N,SIX5
418647,19:46269585:C>T,46269585,NM_175875.4,NM_175875.4:c.1609+23G>A,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,2.132,\N,\N,SIX5
418648,19:46269586:TGAGG>T,46269586,NM_175875.4,NM_175875.4:c.1609+18_1609+21del,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.434,\N,\N,SIX5
418649,19:46269589:G>A,46269589,NM_175875.4,NM_175875.4:c.1609+19C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,1.185,0.00163132,EXAC_AFR_AF,SIX5
418650,19:46269590:G>A,46269590,NM_175875.4,NM_175875.4:c.1609+18C>T,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.089,0.00284091,EXAC_AMR_AF,SIX5
418651,19:46269594:G>A,46269594,NM_175875.4,NM_175875.4:c.1609+14C>T,\N,\N,\N,2/2,Benign,\N,intron_variant,MODIFIER,\N,\N,1.827,0.0151899,EXAC_AMR_AF,SIX5
418652,19:46269596:A>G,46269596,NM_175875.4,NM_175875.4:c.1609+12T>C,\N,\N,\N,2/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,1.215,\N,\N,SIX5
418653,19:46269600:G>A,46269600,NM_175875.4,NM_175875.4:c.1609+8C>T,\N,\N,\N,2/2,Unknown significance,\N,splice_region_variant&intron_variant,LOW,\N,\N,9.185,0.000102145,EXAC_NFE_AF,SIX5
418654,19:46269601:G>A,46269601,NM_175875.4,NM_175875.4:c.1609+7C>T,\N,\N,\N,2/2,Unknown significance,\N,splice_region_variant&intron_variant,LOW,\N,\N,8.663,0.00030006,EXAC_NFE_AF,SIX5
418655,19:46269604:G>T,46269604,NM_175875.4,NM_175875.4:c.1609+4C>A,\N,\N,\N,2/2,Unknown significance,\N,splice_region_variant&intron_variant,LOW,\N,\N,8.528,\N,\N,SIX5
418656,19:46269616:G>A,46269616,NM_175875.4,NM_175875.4:c.1601C>T,NP_787071.2:p.Thr534Ile,534,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,14.99,0.0000732815,EXAC_NFE_AF,SIX5
418657,19:46269618:G>A,46269618,NM_175875.4,NM_175875.4:c.1599C>T,NP_787071.2:p.Ala533=,533,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.851,0.000548246,EXAC_AFR_AF,SIX5
418658,19:46269620:C>T,46269620,NM_175875.4,NM_175875.4:c.1597G>A,NP_787071.2:p.Ala533Thr,533,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,19.18,0.000117647,EVS_EA_AF,SIX5
418659,19:46269621:C>G,46269621,NM_175875.4,NM_175875.4:c.1596G>C,NP_787071.2:p.Ser532=,532,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.72,0.00285927,EXAC_SAS_AF,SIX5
418660,19:46269622:G>A,46269622,NM_175875.4,NM_175875.4:c.1595C>T,NP_787071.2:p.Ser532Leu,532,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,21.7,0.00115473,EXAC_AMR_AF,SIX5
418661,19:46269626:G>A,46269626,NM_175875.4,NM_175875.4:c.1591C>T,NP_787071.2:p.Pro531Ser,531,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26.5,\N,\N,SIX5
418662,19:46269635:G>C,46269635,NM_175875.4,NM_175875.4:c.1582C>G,NP_787071.2:p.Leu528Val,528,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,7.212,0.000305213,EXAC_NFE_AF,SIX5
418663,19:46269638:C>T,46269638,NM_175875.4,NM_175875.4:c.1579G>A,NP_787071.2:p.Ala527Thr,527,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,12.12,0.0029703,EXAC_AMR_AF,SIX5
418664,19:46269644:C>T,46269644,NM_175875.4,NM_175875.4:c.1573G>A,NP_787071.2:p.Val525Met,525,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,21.6,\N,\N,SIX5
418665,19:46269651:C>T,46269651,NM_175875.4,NM_175875.4:c.1566G>A,NP_787071.2:p.Gly522=,522,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.18,0.000925069,EXAC_EAS_AF,SIX5
418666,19:46269654:G>A,46269654,NM_175875.4,NM_175875.4:c.1563C>T,NP_787071.2:p.Ser521=,521,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.59,0.00393701,EXAC_FIN_AF,SIX5
418667,19:46269656:A>G,46269656,NM_175875.4,NM_175875.4:c.1561T>C,NP_787071.2:p.Ser521Pro,521,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,18.92,0.000124938,EXAC_SAS_AF,SIX5
418668,19:46269662:T>A,46269662,NM_175875.4,NM_175875.4:c.1555A>T,NP_787071.2:p.Ile519Phe,519,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,18.94,0.0000623364,EXAC_NFE_AF,SIX5
418669,19:46269666:G>A,46269666,NM_175875.4,NM_175875.4:c.1551C>T,NP_787071.2:p.His517=,517,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,4.68,0.002,1KG_SAS_AF,SIX5
418670,19:46269671:C>A,46269671,NM_175875.4,NM_175875.4:c.1546G>T,NP_787071.2:p.Val516Leu,516,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,19.93,0.0000665779,EXAC_NFE_AF,SIX5
418671,19:46269672:A>G,46269672,NM_175875.4,NM_175875.4:c.1545T>C,NP_787071.2:p.Asn515=,515,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.152,\N,\N,SIX5
418672,19:46269673:T>C,46269673,NM_175875.4,NM_175875.4:c.1544A>G,NP_787071.2:p.Asn515Ser,515,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,13.51,0.000527426,EXAC_EAS_AF,SIX5
418673,19:46269674:T>C,46269674,NM_175875.4,NM_175875.4:c.1543A>G,NP_787071.2:p.Asn515Asp,515,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25,0.0000748279,EXAC_NFE_AF,SIX5
418674,19:46269677:C>T,46269677,NM_175875.4,NM_175875.4:c.1540G>A,NP_787071.2:p.Ala514Thr,514,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,14.35,0.000117151,EVS_EA_AF,SIX5
418675,19:46269681:G>A,46269681,NM_175875.4,NM_175875.4:c.1536C>T,NP_787071.2:p.Gly512=,512,2/3,\N,Benign,\N,synonymous_variant,LOW,\N,\N,8.783,0.023407,EXAC_EAS_AF,SIX5
418676,19:46269681:G>C,46269681,NM_175875.4,NM_175875.4:c.1536C>G,NP_787071.2:p.Gly512=,512,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,5.087,0.0000841893,EXAC_NFE_AF,SIX5
418677,19:46269695:C>G,46269695,NM_175875.4,NM_175875.4:c.1522G>C,NP_787071.2:p.Ala508Pro,508,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.6,\N,\N,SIX5
418678,19:46269712:C>T,46269712,NM_175875.4,NM_175875.4:c.1505G>A,NP_787071.2:p.Gly502Asp,502,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,21.2,0.00016372,EXAC_NFE_AF,SIX5
418679,19:46269716:G>T,46269716,NM_175875.4,NM_175875.4:c.1501C>A,NP_787071.2:p.Pro501Thr,501,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.6,0.000185874,EXAC_NFE_AF,SIX5
418680,19:46269719:C>T,46269719,NM_175875.4,NM_175875.4:c.1498G>A,NP_787071.2:p.Gly500Arg,500,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.9,\N,\N,SIX5
418681,19:46269720:G>C,46269720,NM_175875.4,NM_175875.4:c.1497C>G,NP_787071.2:p.Ala499=,499,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.727,0.000118399,EVS_EA_AF,SIX5
418682,19:46269722:C>T,46269722,NM_175875.4,NM_175875.4:c.1495G>A,NP_787071.2:p.Ala499Thr,499,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,22.1,0.000243546,EXAC_NFE_AF,SIX5
418683,19:46269723:T>C,46269723,NM_175875.4,NM_175875.4:c.1494A>G,NP_787071.2:p.Ala498=,498,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,5.003,\N,\N,SIX5
418684,19:46269738:G>A,46269738,NM_175875.4,NM_175875.4:c.1479C>T,NP_787071.2:p.Pro493=,493,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,6.477,0.000287853,EXAC_NFE_AF,SIX5
418685,19:46269744:C>A,46269744,NM_175875.4,NM_175875.4:c.1473G>T,NP_787071.2:p.Val491=,491,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.86,\N,\N,SIX5
418686,19:46269753:G>C,46269753,NM_175875.4,NM_175875.4:c.1464C>G,NP_787071.2:p.Pro488=,488,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,3.522,0.000315856,EXAC_NFE_AF,SIX5
418687,19:46269755:G>A,46269755,NM_175875.4,NM_175875.4:c.1462C>T,NP_787071.2:p.Pro488Ser,488,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.9,0.001,1KG_EUR_AF,SIX5
418688,19:46269760:G>A,46269760,NM_175875.4,NM_175875.4:c.1457C>T,NP_787071.2:p.Thr486Ile,486,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.6,\N,\N,SIX5
418689,19:46269768:C>G,46269768,NM_175875.4,NM_175875.4:c.1449G>C,NP_787071.2:p.Gln483His,483,2/3,\N,Benign,\N,missense_variant,MODERATE,\N,\N,26.7,0.00753769,EXAC_AFR_AF,SIX5
418690,19:46269792:C>T,46269792,NM_175875.4,NM_175875.4:c.1425G>A,NP_787071.2:p.Leu475=,475,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,1.351,\N,\N,SIX5
418691,19:46269795:G>A,46269795,NM_175875.4,NM_175875.4:c.1422C>T,NP_787071.2:p.Asn474=,474,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.105,0.00034626,EXAC_NFE_AF,SIX5
418692,19:46269798:C>A,46269798,NM_175875.4,NM_175875.4:c.1419G>T,NP_787071.2:p.Leu473Phe,473,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,12.29,0.00035461,EXAC_NFE_AF,SIX5
418693,19:46269814:G>A,46269814,NM_175875.4,NM_175875.4:c.1403C>T,NP_787071.2:p.Pro468Leu,468,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,13.38,\N,\N,SIX5
418694,19:46269817:C>T,46269817,NM_175875.4,NM_175875.4:c.1400G>A,NP_787071.2:p.Ser467Asn,467,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,4.633,0.00188679,EXAC_AFR_AF,SIX5
418695,19:46269821:G>T,46269821,NM_175875.4,NM_175875.4:c.1396C>A,NP_787071.2:p.Leu466Met,466,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,13.55,\N,\N,SIX5
418696,19:46269826:G>A,46269826,NM_175875.4,NM_175875.4:c.1391C>T,NP_787071.2:p.Thr464Met,464,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,12.43,\N,\N,SIX5
418697,19:46269826:G>C,46269826,NM_175875.4,NM_175875.4:c.1391C>G,NP_787071.2:p.Thr464Arg,464,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,10.57,0.0015,1KG_AFR_AF,SIX5
418698,19:46269827:T>A,46269827,NM_175875.4,NM_175875.4:c.1390A>T,NP_787071.2:p.Thr464Ser,464,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.001,0.001,1KG_SAS_AF,SIX5
418699,19:46269837:C>T,46269837,NM_175875.4,NM_175875.4:c.1380G>A,NP_787071.2:p.Pro460=,460,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.013,0.00151515,EXAC_AFR_AF,SIX5
418700,19:46269838:G>A,46269838,NM_175875.4,NM_175875.4:c.1379C>T,NP_787071.2:p.Pro460Leu,460,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,15.7,\N,\N,SIX5
418701,19:46269839:G>C,46269839,NM_175875.4,NM_175875.4:c.1378C>G,NP_787071.2:p.Pro460Ala,460,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.002,\N,\N,SIX5
418702,19:46269841:G>C,46269841,NM_175875.4,NM_175875.4:c.1376C>G,NP_787071.2:p.Pro459Arg,459,2/3,\N,Benign,\N,missense_variant,MODERATE,\N,\N,18.35,0.00757576,EXAC_EAS_AF,SIX5
418703,19:46269842:G>T,46269842,NM_175875.4,NM_175875.4:c.1375C>A,NP_787071.2:p.Pro459Thr,459,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,8.666,\N,\N,SIX5
418704,19:46269846:G>A,46269846,NM_175875.4,NM_175875.4:c.1371C>T,NP_787071.2:p.Ser457=,457,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.33,0.000739645,EXAC_NFE_AF,SIX5
418705,19:46269851:G>A,46269851,NM_175875.4,NM_175875.4:c.1366C>T,NP_787071.2:p.Leu456Phe,456,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,23.3,0.00442478,EXAC_SAS_AF,SIX5
418706,19:46269857:C>T,46269857,NM_175875.4,NM_175875.4:c.1360G>A,NP_787071.2:p.Val454Ile,454,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.8,\N,\N,SIX5
418707,19:46269868:G>C,46269868,NM_175875.4,NM_175875.4:c.1349C>G,NP_787071.2:p.Ala450Gly,450,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,12.4,\N,\N,SIX5
418708,19:46269876:AGCAGGCACT>A,46269876,NM_175875.4,NM_175875.4:c.1332_1340del,NP_787071.2:p.Pro446_Val448del,444-447,2/3,\N,Unknown significance,\N,inframe_deletion,MODERATE,\N,\N,13.26,\N,\N,SIX5
418709,19:46269887:G>A,46269887,NM_175875.4,NM_175875.4:c.1330C>T,NP_787071.2:p.Pro444Ser,444,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.141,\N,\N,SIX5
418710,19:46269889:C>A,46269889,NM_175875.4,NM_175875.4:c.1328G>T,NP_787071.2:p.Gly443Val,443,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.7,\N,\N,SIX5
418711,19:46269891:C>G,46269891,NM_175875.4,NM_175875.4:c.1326G>C,NP_787071.2:p.Pro442=,442,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,3.723,\N,\N,SIX5
418712,19:46269892:G>A,46269892,NM_175875.4,NM_175875.4:c.1325C>T,NP_787071.2:p.Pro442Leu,442,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.2,0.0008,1KG_AFR_AF,SIX5
418713,19:46269895:G>A,46269895,NM_175875.4,NM_175875.4:c.1322C>T,NP_787071.2:p.Pro441Leu,441,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,5.91,0.00234742,EXAC_SAS_AF,SIX5
418714,19:46269916:G>A,46269916,NM_175875.4,NM_175875.4:c.1301C>T,NP_787071.2:p.Thr434Met,434,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,14.38,\N,\N,SIX5
418715,19:46269919:G>A,46269919,NM_175875.4,NM_175875.4:c.1298C>T,NP_787071.2:p.Pro433Leu,433,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23,\N,\N,SIX5
418716,19:46269929:G>T,46269929,NM_175875.4,NM_175875.4:c.1288C>A,NP_787071.2:p.Pro430Thr,430,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,21.5,\N,\N,SIX5
418717,19:46269930:C>A,46269930,NM_175875.4,NM_175875.4:c.1287G>T,NP_787071.2:p.Val429=,429,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.64,0,EXAC_ALL_AF|EXAC_AFR_AF|EXAC_AMR_AF|EXAC_EAS_AF|EXAC_FIN_AF|EXAC_NFE_AF|EXAC_OTH_AF|EXAC_SAS_AF,SIX5
418718,19:46269930:C>T,46269930,NM_175875.4,NM_175875.4:c.1287G>A,NP_787071.2:p.Val429=,429,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.72,0.00065445,EXAC_SAS_AF,SIX5
418719,19:46269939:G>A,46269939,NM_175875.4,NM_175875.4:c.1278C>T,NP_787071.2:p.Ala426=,426,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.379,\N,\N,SIX5
418720,19:46269946:G>A,46269946,NM_175875.4,NM_175875.4:c.1271C>T,NP_787071.2:p.Pro424Leu,424,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23,0.000514933,EXAC_NFE_AF,SIX5
418721,19:46269953:G>A,46269953,NM_175875.4,NM_175875.4:c.1264C>T,NP_787071.2:p.Leu422=,422,2/3,\N,Benign,\N,synonymous_variant,LOW,\N,\N,0.018,0.0152439,EXAC_AFR_AF,SIX5
418722,19:46269978:C>T,46269978,NM_175875.4,NM_175875.4:c.1239G>A,NP_787071.2:p.Pro413=,413,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,4.869,\N,\N,SIX5
418723,19:46269979:G>A,46269979,NM_175875.4,NM_175875.4:c.1238C>T,NP_787071.2:p.Pro413Leu,413,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,4.725,\N,\N,SIX5
418724,19:46269985:G>A,46269985,NM_175875.4,NM_175875.4:c.1232C>T,NP_787071.2:p.Ala411Val,411,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,1.655,\N,\N,SIX5
418725,19:46269986:C>A,46269986,NM_175875.4,NM_175875.4:c.1231G>T,NP_787071.2:p.Ala411Ser,411,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.005,0.000157629,EXAC_SAS_AF,SIX5
418726,19:46269989:C>T,46269989,NM_175875.4,NM_175875.4:c.1228G>A,NP_787071.2:p.Val410Met,410,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,15.81,0.000986193,EXAC_AMR_AF,SIX5
418727,19:46269994:G>T,46269994,NM_175875.4,NM_175875.4:c.1223C>A,NP_787071.2:p.Ala408Asp,408,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.033,0.00137363,EXAC_AFR_AF,SIX5
418728,19:46270004:T>A,46270004,NM_175875.4,NM_175875.4:c.1213A>T,NP_787071.2:p.Thr405Ser,405,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.114,0.00123457,EXAC_AFR_AF,SIX5
418729,19:46270007:C>G,46270007,NM_175875.4,NM_175875.4:c.1210G>C,NP_787071.2:p.Glu404Gln,404,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,9.16,0.00131579,EXAC_AMR_AF,SIX5
418730,19:46270008:A>G,46270008,NM_175875.4,NM_175875.4:c.1209T>C,NP_787071.2:p.Pro403=,403,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.207,0.000121183,EXAC_NFE_AF,SIX5
418731,19:46270010:G>A,46270010,NM_175875.4,NM_175875.4:c.1207C>T,NP_787071.2:p.Pro403Ser,403,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,1.894,0.000621118,EXAC_AMR_AF,SIX5
418732,19:46270012:G>A,46270012,NM_175875.4,NM_175875.4:c.1205C>T,NP_787071.2:p.Ala402Val,402,2/3,\N,Benign,\N,missense_variant,MODERATE,\N,\N,14.42,0.00555556,EXAC_OTH_AF,SIX5
418733,19:46270031:C>T,46270031,NM_175875.4,NM_175875.4:c.1186G>A,NP_787071.2:p.Glu396Lys,396,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,21.9,0.001,1KG_SAS_AF,SIX5
418734,19:46270044:C>T,46270044,NM_175875.4,NM_175875.4:c.1173G>A,NP_787071.2:p.Gly391=,391,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.88,\N,\N,SIX5
418735,19:46270045:C>T,46270045,NM_175875.4,NM_175875.4:c.1172G>A,NP_787071.2:p.Gly391Glu,391,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.3,0.000121625,EXAC_SAS_AF,SIX5
418736,19:46270046:C>T,46270046,NM_175875.4,NM_175875.4:c.1171G>A,NP_787071.2:p.Gly391Arg,391,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.5,\N,\N,SIX5
418737,19:46270047:T>C,46270047,NM_175875.4,NM_175875.4:c.1170A>G,NP_787071.2:p.Thr390=,390,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.479,0.000102606,EXAC_NFE_AF,SIX5
418738,19:46270050:C>T,46270050,NM_175875.4,NM_175875.4:c.1167G>A,NP_787071.2:p.Gln389=,389,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.75,0.00085034,EXAC_EAS_AF,SIX5
418739,19:46270051:T>C,46270051,NM_175875.4,NM_175875.4:c.1166A>G,NP_787071.2:p.Gln389Arg,389,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23,0.0001048,EXAC_NFE_AF,SIX5
418740,19:46270054:G>A,46270054,NM_175875.4,NM_175875.4:c.1163C>T,NP_787071.2:p.Pro388Leu,388,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.6,0.000107968,EXAC_NFE_AF,SIX5
418741,19:46270069:G>A,46270069,NM_175875.4,NM_175875.4:c.1148C>T,NP_787071.2:p.Ser383Phe,383,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.5,0.000124347,EXAC_NFE_AF,SIX5
418742,19:46270071:G>A,46270071,NM_175875.4,NM_175875.4:c.1146C>T,NP_787071.2:p.Thr382=,382,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,5.383,0.000125881,EXAC_SAS_AF,SIX5
418743,19:46270072:G>A,46270072,NM_175875.4,NM_175875.4:c.1145C>T,NP_787071.2:p.Thr382Ile,382,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,22.8,0.00105708,EXAC_AFR_AF,SIX5
418744,19:46270076:T>C,46270076,NM_175875.4,NM_175875.4:c.1141A>G,NP_787071.2:p.Lys381Glu,381,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,14.66,0.000159134,EXAC_NFE_AF,SIX5
418745,19:46270085:T>G,46270085,NM_175875.4,NM_175875.4:c.1132A>C,NP_787071.2:p.Ser378Arg,378,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,14.01,0.00170648,EXAC_EAS_AF,SIX5
418746,19:46270086:G>A,46270086,NM_175875.4,NM_175875.4:c.1131C>T,NP_787071.2:p.Ala377=,377,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.788,\N,\N,SIX5
418747,19:46270090:C>T,46270090,NM_175875.4,NM_175875.4:c.1127G>A,NP_787071.2:p.Gly376Glu,376,2/3,\N,Benign,\N,missense_variant,MODERATE,\N,\N,23,0.00657895,EXAC_OTH_AF,SIX5
418748,19:46270091:CCT>C,46270091,NM_175875.4,NM_175875.4:c.1124_1125del,NP_787071.2:p.Gln375ArgfsTer29,375,2/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,23.7,\N,\N,SIX5
418749,19:46270107:C>T,46270107,NM_175875.4,NM_175875.4:c.1110G>A,NP_787071.2:p.Pro370=,370,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.8,\N,\N,SIX5
418750,19:46270108:G>C,46270108,NM_175875.4,NM_175875.4:c.1109C>G,NP_787071.2:p.Pro370Arg,370,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,21.2,0.000133905,EXAC_SAS_AF,SIX5
418751,19:46270112:G>C,46270112,NM_175875.4,NM_175875.4:c.1105C>G,NP_787071.2:p.Pro369Ala,369,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.034,\N,\N,SIX5
418752,19:46270112:G>T,46270112,NM_175875.4,NM_175875.4:c.1105C>A,NP_787071.2:p.Pro369Thr,369,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,0.165,0.001,1KG_EAS_AF,SIX5
418753,19:46270114:G>A,46270114,NM_175875.4,NM_175875.4:c.1103C>T,NP_787071.2:p.Pro368Leu,368,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,8.763,0,EXAC_ALL_AF|EXAC_AFR_AF|EXAC_AMR_AF|EXAC_EAS_AF|EXAC_FIN_AF|EXAC_NFE_AF|EXAC_OTH_AF|EXAC_SAS_AF,SIX5
418754,19:46270114:G>T,46270114,NM_175875.4,NM_175875.4:c.1103C>A,NP_787071.2:p.Pro368His,368,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,14.85,0.0026178,EXAC_EAS_AF,SIX5
418755,19:46270116:G>A,46270116,NM_175875.4,NM_175875.4:c.1101C>T,NP_787071.2:p.Ala367=,367,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,3.292,0.000235849,EXAC_NFE_AF,SIX5
418756,19:46270117:G>A,46270117,NM_175875.4,NM_175875.4:c.1100C>T,NP_787071.2:p.Ala367Val,367,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,1.342,0.000236295,EXAC_NFE_AF,SIX5
418757,19:46270124:C>T,46270124,NM_175875.4,NM_175875.4:c.1093G>A,NP_787071.2:p.Gly365Arg,365,2/3,\N,Pathogenic,Branchio-oto-renal syndrome,missense_variant,MODERATE,\N,\N,21.4,0.00259067,EXAC_EAS_AF,SIX5
418758,19:46270126:C>A,46270126,NM_175875.4,NM_175875.4:c.1091G>T,NP_787071.2:p.Gly364Val,364,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23,0.000227376,EXAC_NFE_AF,SIX5
418759,19:46270129:C>A,46270129,NM_175875.4,NM_175875.4:c.1088G>T,NP_787071.2:p.Gly363Val,363,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.2,\N,\N,SIX5
418760,19:46270137:C>A,46270137,NM_175875.4,NM_175875.4:c.1080G>T,NP_787071.2:p.Leu360=,360,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.3,\N,\N,SIX5
418761,19:46270142:G>T,46270142,NM_175875.4,NM_175875.4:c.1075C>A,NP_787071.2:p.Leu359Met,359,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.5,\N,\N,SIX5
418762,19:46270143:C>T,46270143,NM_175875.4,NM_175875.4:c.1074G>A,NP_787071.2:p.Pro358=,358,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,15.09,\N,\N,SIX5
418763,19:46270175:G>A,46270175,NM_175875.4,NM_175875.4:c.1042C>T,NP_787071.2:p.Leu348=,348,2/3,\N,Benign,\N,synonymous_variant,LOW,\N,\N,5.472,0.0224551,EXAC_AMR_AF,SIX5
418764,19:46270179:G>A,46270179,NM_175875.4,NM_175875.4:c.1038C>T,NP_787071.2:p.Asn346=,346,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,6.064,0.001,1KG_EAS_AF,SIX5
418765,19:46270190:C>T,46270190,NM_175875.4,NM_175875.4:c.1027G>A,NP_787071.2:p.Val343Ile,343,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.3,0.0008,EXAC_AFR_AF,SIX5
418766,19:46270192:G>A,46270192,NM_175875.4,NM_175875.4:c.1025C>T,NP_787071.2:p.Pro342Leu,342,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.1,0.001,1KG_EUR_AF,SIX5
418767,19:46270193:G>A,46270193,NM_175875.4,NM_175875.4:c.1024C>T,NP_787071.2:p.Pro342Ser,342,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,1.446,\N,\N,SIX5
418768,19:46270194:G>A,46270194,NM_175875.4,NM_175875.4:c.1023C>T,NP_787071.2:p.Gly341=,341,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.574,\N,\N,SIX5
418769,19:46270194:G>GC,46270194,NM_175875.4,NM_175875.4:c.1022dup,NP_787071.2:p.Val343ArgfsTer62,341,2/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,25,\N,\N,SIX5
418770,19:46270194:G>T,46270194,NM_175875.4,NM_175875.4:c.1023C>A,NP_787071.2:p.Gly341=,341,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.095,\N,\N,SIX5
418771,19:46270199:C>G,46270199,NM_175875.4,NM_175875.4:c.1018G>C,NP_787071.2:p.Gly340Arg,340,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.9,0.000101937,EXAC_NFE_AF,SIX5
418772,19:46270200:G>A,46270200,NM_175875.4,NM_175875.4:c.1017C>T,NP_787071.2:p.Asn339=,339,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.97,0.0000983478,EXAC_NFE_AF,SIX5
418773,19:46270203:G>A,46270203,NM_175875.4,NM_175875.4:c.1014C>T,NP_787071.2:p.Leu338=,338,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.123,0.000612745,EXAC_AFR_AF,SIX5
418774,19:46270203:G>T,46270203,NM_175875.4,NM_175875.4:c.1014C>A,NP_787071.2:p.Leu338=,338,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.02,0.0029,1KG_AMR_AF,SIX5
418775,19:46270206:G>A,46270206,NM_175875.4,NM_175875.4:c.1011C>T,NP_787071.2:p.Leu337=,337,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.046,\N,\N,SIX5
418776,19:46270211:C>T,46270211,NM_175875.4,NM_175875.4:c.1006G>A,NP_787071.2:p.Val336Met,336,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,17.19,\N,\N,SIX5
418777,19:46270217:G>A,46270217,NM_175875.4,NM_175875.4:c.1000C>T,NP_787071.2:p.Pro334Ser,334,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,8.984,0.00192678,EXAC_AFR_AF,SIX5
418778,19:46270219:G>A,46270219,NM_175875.4,NM_175875.4:c.998C>T,NP_787071.2:p.Ser333Phe,333,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.9,0.0014,1KG_AMR_AF,SIX5
418779,19:46270223:C>T,46270223,NM_175875.4,NM_175875.4:c.994G>A,NP_787071.2:p.Gly332Ser,332,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,8.113,0.001,1KG_SAS_AF,SIX5
418780,19:46270224:G>A,46270224,NM_175875.4,NM_175875.4:c.993C>T,NP_787071.2:p.Ser331=,331,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.341,0.000424448,EXAC_AMR_AF,SIX5
418781,19:46270230:T>C,46270230,NM_175875.4,NM_175875.4:c.987A>G,NP_787071.2:p.Ala329=,329,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.031,\N,\N,SIX5
418782,19:46270238:A>T,46270238,NM_175875.4,NM_175875.4:c.979T>A,NP_787071.2:p.Phe327Ile,327,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,17.14,\N,\N,SIX5
418783,19:46270240:C>T,46270240,NM_175875.4,NM_175875.4:c.977G>A,NP_787071.2:p.Ser326Asn,326,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,13.38,0.0000977135,EXAC_SAS_AF,SIX5
418784,19:46270244:C>G,46270244,NM_175875.4,NM_175875.4:c.973G>C,NP_787071.2:p.Gly325Arg,325,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.8,0.0000952562,EXAC_SAS_AF,SIX5
418785,19:46270245:G>T,46270245,NM_175875.4,NM_175875.4:c.972C>A,NP_787071.2:p.Asn324Lys,324,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.3,\N,\N,SIX5
418786,19:46270254:G>A,46270254,NM_175875.4,NM_175875.4:c.963C>T,NP_787071.2:p.Ile321=,321,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.9,0.00023753,EXAC_AFR_AF,SIX5
418787,19:46270254:G>C,46270254,NM_175875.4,NM_175875.4:c.963C>G,NP_787071.2:p.Ile321Met,321,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.1,0.00023753,EXAC_AFR_AF,SIX5
418788,19:46270256:TGGA>T,46270256,NM_175875.4,NM_175875.4:c.958_960del,NP_787071.2:p.Ser320del,320,2/3,\N,Unknown significance,\N,inframe_deletion,MODERATE,\N,\N,18.79,\N,\N,SIX5
418789,19:46270261:G>A,46270261,NM_175875.4,NM_175875.4:c.956C>T,NP_787071.2:p.Ser319Phe,319,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.1,0.0000285698,EXAC_NFE_AF,SIX5
418790,19:46270264:G>A,46270264,NM_175875.4,NM_175875.4:c.953C>T,NP_787071.2:p.Ser318Phe,318,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.8,0.0000843313,EXAC_SAS_AF,SIX5
418791,19:46270266:A>C,46270266,NM_175875.4,NM_175875.4:c.951T>G,NP_787071.2:p.Ala317=,317,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.072,\N,\N,SIX5
418792,19:46270267:G>A,46270267,NM_175875.4,NM_175875.4:c.950C>T,NP_787071.2:p.Ala317Val,317,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,17.3,0.000333556,EXAC_SAS_AF,SIX5
418793,19:46270268:C>G,46270268,NM_175875.4,NM_175875.4:c.949G>C,NP_787071.2:p.Ala317Pro,317,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,22.3,0.00020016,EXAC_AFR_AF,SIX5
418794,19:46270268:C>T,46270268,NM_175875.4,NM_175875.4:c.949G>A,NP_787071.2:p.Ala317Thr,317,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,11.16,0.0000831532,EXAC_SAS_AF,SIX5
418795,19:46270270:G>A,46270270,NM_175875.4,NM_175875.4:c.947C>T,NP_787071.2:p.Pro316Leu,316,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,18.14,0.001,1KG_SAS_AF,SIX5
418796,19:46270270:G>C,46270270,NM_175875.4,NM_175875.4:c.947C>G,NP_787071.2:p.Pro316Arg,316,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,22.6,0.000389712,EXAC_EAS_AF,SIX5
418797,19:46270271:G>A,46270271,NM_175875.4,NM_175875.4:c.946C>T,NP_787071.2:p.Pro316Ser,316,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,1.17,0.000357143,EXAC_FIN_AF,SIX5
418798,19:46270277:G>A,46270277,NM_175875.4,NM_175875.4:c.940C>T,NP_787071.2:p.Pro314Ser,314,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.004,0.00011685,EVS_EA_AF,SIX5
418799,19:46270279:G>A,46270279,NM_175875.4,NM_175875.4:c.938C>T,NP_787071.2:p.Ala313Val,313,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,8.953,0.0000228154,EXAC_NFE_AF,SIX5
418800,19:46270281:G>A,46270281,NM_175875.4,NM_175875.4:c.936C>T,NP_787071.2:p.Pro312=,312,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,1.561,0.00121544,EXAC_SAS_AF,SIX5
418801,19:46270281:G>C,46270281,NM_175875.4,NM_175875.4:c.936C>G,NP_787071.2:p.Pro312=,312,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.189,0.000167056,EXAC_EAS_AF,SIX5
418802,19:46270283:G>T,46270283,NM_175875.4,NM_175875.4:c.934C>A,NP_787071.2:p.Pro312Thr,312,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.011,0.0000430608,EXAC_NFE_AF,SIX5
418803,19:46270285:G>A,46270285,NM_175875.4,NM_175875.4:c.932C>T,NP_787071.2:p.Pro311Leu,311,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,8.015,0.0000632031,EXAC_NFE_AF,SIX5
418804,19:46270286:G>A,46270286,NM_175875.4,NM_175875.4:c.931C>T,NP_787071.2:p.Pro311Ser,311,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.004,0.000220588,EXAC_SAS_AF,SIX5
418805,19:46270287:G>A,46270287,NM_175875.4,NM_175875.4:c.930C>T,NP_787071.2:p.Gly310=,310,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.331,\N,\N,SIX5
418806,19:46270289:C>T,46270289,NM_175875.4,NM_175875.4:c.928G>A,NP_787071.2:p.Gly310Ser,310,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.158,0.000151699,EXAC_EAS_AF,SIX5
418807,19:46270290:G>A,46270290,NM_175875.4,NM_175875.4:c.927C>T,NP_787071.2:p.Thr309=,309,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,6.762,0.000116768,EVS_EA_AF,SIX5
418808,19:46270298:C>T,46270298,NM_175875.4,NM_175875.4:c.919G>A,NP_787071.2:p.Ala307Thr,307,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,9.458,0.000129476,EXAC_NFE_AF,SIX5
418809,19:46270299:C>T,46270299,NM_175875.4,NM_175875.4:c.918G>A,NP_787071.2:p.Leu306=,306,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,6.244,0.0000678887,EXAC_SAS_AF,SIX5
418810,19:46270300:A>G,46270300,NM_175875.4,NM_175875.4:c.917T>C,NP_787071.2:p.Leu306Pro,306,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,22.2,0.0000182775,EXAC_NFE_AF,SIX5
418811,19:46270302:G>A,46270302,NM_175875.4,NM_175875.4:c.915C>T,NP_787071.2:p.Phe305=,305,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.459,0.000262123,EXAC_EAS_AF,SIX5
418812,19:46270308:G>A,46270308,NM_175875.4,NM_175875.4:c.909C>T,NP_787071.2:p.Ser303=,303,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,3.55,0.000017716,EXAC_NFE_AF,SIX5
418813,19:46270309:G>A,46270309,NM_175875.4,NM_175875.4:c.908C>T,NP_787071.2:p.Ser303Phe,303,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23,0.0000176616,EXAC_NFE_AF,SIX5
418814,19:46270313:C>A,46270313,NM_175875.4,NM_175875.4:c.904G>T,NP_787071.2:p.Gly302Cys,302,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,20.4,0.000130753,EXAC_SAS_AF,SIX5
418815,19:46270313:C>T,46270313,NM_175875.4,NM_175875.4:c.904G>A,NP_787071.2:p.Gly302Ser,302,2/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,0.072,0.0000653766,EXAC_SAS_AF,SIX5
418816,19:46270315:T>A,46270315,NM_175875.4,NM_175875.4:c.902A>T,NP_787071.2:p.Gln301Leu,301,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,6.19,0.0014,1KG_AMR_AF,SIX5
418817,19:46270317:G>C,46270317,NM_175875.4,NM_175875.4:c.900C>G,NP_787071.2:p.Ala300=,300,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.036,0.001,1KG_EUR_AF,SIX5
418818,19:46270329:G>T,46270329,NM_175875.4,NM_175875.4:c.888C>A,NP_787071.2:p.Ala296=,296,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,1.585,0.000121981,EXAC_EAS_AF,SIX5
418819,19:46270331:C>T,46270331,NM_175875.4,NM_175875.4:c.886G>A,NP_787071.2:p.Ala296Thr,296,2/3,\N,Pathogenic,Branchio-oto-renal syndrome,missense_variant,MODERATE,\N,\N,0.056,0.000116904,EVS_EA_AF,SIX5
418820,19:46270332:G>C,46270332,NM_175875.4,NM_175875.4:c.885C>G,NP_787071.2:p.Ser295=,295,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.626,\N,\N,SIX5
418821,19:46270362:C>T,46270362,NM_175875.4,NM_175875.4:c.855G>A,NP_787071.2:p.Glu285=,285,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.68,0.000180115,EXAC_AMR_AF,SIX5
418822,19:46270371:T>G,46270371,NM_175875.4,NM_175875.4:c.846A>C,NP_787071.2:p.Arg282=,282,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,6.836,0.0000165931,EXAC_NFE_AF,SIX5
418823,19:46270372:C>G,46270372,NM_175875.4,NM_175875.4:c.845G>C,NP_787071.2:p.Arg282Pro,282,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.3,0.0000627746,EXAC_SAS_AF,SIX5
418824,19:46270374:G>A,46270374,NM_175875.4,NM_175875.4:c.843C>T,NP_787071.2:p.Ser281=,281,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.65,0.000241196,EXAC_EAS_AF,SIX5
418825,19:46270374:G>GA,46270374,NM_175875.4,NM_175875.4:c.842_843insT,NP_787071.2:p.Arg282ProfsTer4,281,2/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,33,0.0000627904,EXAC_SAS_AF,SIX5
418826,19:46270378:G>C,46270378,NM_175875.4,NM_175875.4:c.839C>G,NP_787071.2:p.Ser280Cys,280,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,18,0.000241779,EXAC_EAS_AF,SIX5
418827,19:46270383:G>A,46270383,NM_175875.4,NM_175875.4:c.834C>T,NP_787071.2:p.Asp278=,278,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.37,0.000119617,EXAC_AFR_AF,SIX5
418828,19:46270383:G>T,46270383,NM_175875.4,NM_175875.4:c.834C>A,NP_787071.2:p.Asp278Glu,278,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.4,0.0015,1KG_AFR_AF,SIX5
418829,19:46270384:T>G,46270384,NM_175875.4,NM_175875.4:c.833A>C,NP_787071.2:p.Asp278Ala,278,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26.2,\N,\N,SIX5
418830,19:46270385:C>T,46270385,NM_175875.4,NM_175875.4:c.832G>A,NP_787071.2:p.Asp278Asn,278,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,31,0.001,1KG_EAS_AF,SIX5
418831,19:46270388:C>G,46270388,NM_175875.4,NM_175875.4:c.829G>C,NP_787071.2:p.Glu277Gln,277,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.7,0.0000167983,EXAC_NFE_AF,SIX5
418832,19:46270396:G>A,46270396,NM_175875.4,NM_175875.4:c.821C>T,NP_787071.2:p.Pro274Leu,274,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,22.2,0.00250986,EXAC_FIN_AF,SIX5
418833,19:46270402:C>T,46270402,NM_175875.4,NM_175875.4:c.815G>A,NP_787071.2:p.Gly272Glu,272,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,32,0.000328861,EXAC_SAS_AF,SIX5
418834,19:46270406:C>T,46270406,NM_175875.4,NM_175875.4:c.811G>A,NP_787071.2:p.Asp271Asn,271,2/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,24.8,0.00347133,EXAC_AFR_AF,SIX5
418835,19:46270410:C>T,46270410,NM_175875.4,NM_175875.4:c.807G>A,NP_787071.2:p.Glu269=,269,2/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.95,0.0000974659,EXAC_AMR_AF,SIX5
418836,19:46270413:G>C,46270413,NM_175875.4,NM_175875.4:c.804C>G,NP_787071.2:p.Ser268Arg,268,2/3,\N,Unknown significance,\N,missense_variant&splice_region_variant,MODERATE,\N,\N,19.55,0.0000183446,EXAC_NFE_AF,SIX5
418837,19:46270419:C>A,46270419,NM_175875.4,NM_175875.4:c.804-6G>T,\N,\N,\N,1/2,Unknown significance,\N,splice_region_variant&intron_variant,LOW,\N,\N,1.329,0.0000187441,EXAC_NFE_AF,SIX5
418838,19:46270420:G>A,46270420,NM_175875.4,NM_175875.4:c.804-7C>T,\N,\N,\N,1/2,Unknown significance,\N,splice_region_variant&intron_variant,LOW,\N,\N,1.24,0.002,1KG_EAS_AF,SIX5
418839,19:46270421:G>A,46270421,NM_175875.4,NM_175875.4:c.804-8C>T,\N,\N,\N,1/2,Unknown significance,\N,splice_region_variant&intron_variant,LOW,\N,\N,5.07,0.0000699007,EXAC_SAS_AF,SIX5
418840,19:46270423:G>A,46270423,NM_175875.4,NM_175875.4:c.804-10C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,7.654,0.000019138,EXAC_NFE_AF,SIX5
418841,19:46270427:T>C,46270427,NM_175875.4,NM_175875.4:c.804-14A>G,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,6.17,0.000322997,EXAC_AMR_AF,SIX5
418842,19:46270428:G>A,46270428,NM_175875.4,NM_175875.4:c.804-15C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,8.018,0.0000392388,EXAC_NFE_AF,SIX5
418843,19:46270430:C>T,46270430,NM_175875.4,NM_175875.4:c.804-17G>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,5.755,0.000214347,EXAC_SAS_AF,SIX5
418844,19:46270436:G>C,46270436,NM_175875.4,NM_175875.4:c.804-23C>G,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,4.293,0.0000205019,EXAC_NFE_AF,SIX5
418845,19:46270439:G>A,46270439,NM_175875.4,NM_175875.4:c.804-26C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,7.188,0.000236518,EXAC_FIN_AF,SIX5
418846,19:46270440:G>A,46270440,NM_175875.4,NM_175875.4:c.804-27C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,4.234,0.000021173,EXAC_NFE_AF,SIX5
418847,19:46270445:C>G,46270445,NM_175875.4,NM_175875.4:c.804-32G>C,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,6.571,0.00163399,EXAC_OTH_AF,SIX5
418848,19:46270450:G>T,46270450,NM_175875.4,NM_175875.4:c.804-37C>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,4.846,0.000120308,EVS_EA_AF,SIX5
418849,19:46270453:T>C,46270453,NM_175875.4,NM_175875.4:c.804-40A>G,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,3.074,0.0000233372,EXAC_NFE_AF,SIX5
418850,19:46270457:G>A,46270457,NM_175875.4,NM_175875.4:c.804-44C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,6.785,0.0000800256,EXAC_SAS_AF,SIX5
418851,19:46270465:C>T,46270465,NM_175875.4,NM_175875.4:c.804-52G>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,7.214,0.0000831532,EXAC_SAS_AF,SIX5
418852,19:46270476:C>A,46270476,NM_175875.4,NM_175875.4:c.804-63G>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,7.784,0.0008,1KG_AFR_AF,SIX5
418853,19:46270489:C>G,46270489,NM_175875.4,NM_175875.4:c.804-76G>C,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,6.225,0.001,1KG_EUR_AF,SIX5
418854,19:46270519:C>T,46270519,NM_175875.4,NM_175875.4:c.804-106G>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,7.176,\N,\N,SIX5
418855,19:46270528:G>A,46270528,NM_175875.4,NM_175875.4:c.804-115C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,3.365,0.001,1KG_EUR_AF,SIX5
418856,19:46270529:G>C,46270529,NM_175875.4,NM_175875.4:c.804-116C>G,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,4.723,0.0008,1KG_AFR_AF,SIX5
418857,19:46270563:A>G,46270563,NM_175875.4,NM_175875.4:c.804-150T>C,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,7.172,0.0008,1KG_AFR_AF,SIX5
418858,19:46270613:A>T,46270613,NM_175875.4,NM_175875.4:c.804-200T>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,9.01,\N,\N,SIX5
418859,19:46270628:G>A,46270628,NM_175875.4,NM_175875.4:c.804-215C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,8.105,\N,\N,SIX5
418860,19:46270637:C>G,46270637,NM_175875.4,NM_175875.4:c.804-224G>C,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,4.95,\N,\N,SIX5
418861,19:46270640:C>T,46270640,NM_175875.4,NM_175875.4:c.804-227G>A,\N,\N,\N,1/2,Benign,\N,intron_variant,MODIFIER,\N,\N,8,0.0915,1KG_AFR_AF,SIX5
418862,19:46270658:G>C,46270658,NM_175875.4,NM_175875.4:c.804-245C>G,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,4.358,0.001,1KG_EAS_AF,SIX5
418863,19:46270677:G>A,46270677,NM_175875.4,NM_175875.4:c.804-264C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,8.297,\N,\N,SIX5
418864,19:46270682:A>G,46270682,NM_175875.4,NM_175875.4:c.804-269T>C,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,3.877,\N,\N,SIX5
418865,19:46270721:G>A,46270721,NM_175875.4,NM_175875.4:c.804-308C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,5.815,\N,\N,SIX5
418866,19:46270724:G>A,46270724,NM_175875.4,NM_175875.4:c.804-311C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,8.198,\N,\N,SIX5
418867,19:46270749:A>G,46270749,NM_175875.4,NM_175875.4:c.804-336T>C,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,4.57,\N,\N,SIX5
418868,19:46270755:C>T,46270755,NM_175875.4,NM_175875.4:c.804-342G>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,11.48,\N,\N,SIX5
418869,19:46270770:G>A,46270770,NM_175875.4,NM_175875.4:c.804-357C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,13.36,0.002,1KG_EAS_AF,SIX5
418870,19:46270811:G>A,46270811,NM_175875.4,NM_175875.4:c.804-398C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,18.84,0.001,1KG_SAS_AF,SIX5
418871,19:46270813:G>A,46270813,NM_175875.4,NM_175875.4:c.804-400C>T,\N,\N,\N,1/2,Benign,\N,intron_variant,MODIFIER,\N,\N,19.42,0.0092,1KG_SAS_AF,SIX5
418872,19:46270817:G>A,46270817,NM_175875.4,NM_175875.4:c.804-404C>T,\N,\N,\N,1/2,Benign,\N,intron_variant,MODIFIER,\N,\N,20.7,0.0058,1KG_AMR_AF,SIX5
418873,19:46270830:G>A,46270830,NM_175875.4,NM_175875.4:c.804-417C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,18.81,0.001,1KG_SAS_AF,SIX5
418874,19:46270838:G>A,46270838,NM_175875.4,NM_175875.4:c.804-425C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,18.72,0.001,1KG_SAS_AF,SIX5
418875,19:46270895:GGCCC>G,46270895,NM_175875.4,NM_175875.4:c.803+401_803+404del,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,\N,\N,\N,SIX5
418876,19:46270959:G>A,46270959,NM_175875.4,NM_175875.4:c.803+341C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,2.914,0.0014,1KG_AMR_AF,SIX5
418877,19:46270965:C>T,46270965,NM_175875.4,NM_175875.4:c.803+335G>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,6.901,\N,\N,SIX5
418878,19:46270977:T>G,46270977,NM_175875.4,NM_175875.4:c.803+323A>C,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,6.895,0.0008,1KG_AFR_AF,SIX5
418879,19:46271069:T>C,46271069,NM_175875.4,NM_175875.4:c.803+231A>G,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,4.501,0.0008,1KG_AFR_AF,SIX5
418880,19:46271099:G>A,46271099,NM_175875.4,NM_175875.4:c.803+201C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,7.439,0.0014,1KG_AMR_AF,SIX5
418881,19:46271102:C>A,46271102,NM_175875.4,NM_175875.4:c.803+198G>T,\N,\N,\N,1/2,Benign,\N,intron_variant,MODIFIER,\N,\N,11.32,0.0076,1KG_AFR_AF,SIX5
418882,19:46271125:C>T,46271125,NM_175875.4,NM_175875.4:c.803+175G>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,6.015,\N,\N,SIX5
418883,19:46271138:C>T,46271138,NM_175875.4,NM_175875.4:c.803+162G>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,10.69,0.002,1KG_EUR_AF,SIX5
418884,19:46271156:C>A,46271156,NM_175875.4,NM_175875.4:c.803+144G>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,11.12,0.001,1KG_EAS_AF,SIX5
418885,19:46271177:G>T,46271177,NM_175875.4,NM_175875.4:c.803+123C>A,\N,\N,\N,1/2,Benign,\N,intron_variant,MODIFIER,\N,\N,8.556,0.647,1KG_AMR_AF,SIX5
418886,19:46271206:G>C,46271206,NM_175875.4,NM_175875.4:c.803+94C>G,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,4.297,0.001,1KG_SAS_AF,SIX5
418887,19:46271207:G>A,46271207,NM_175875.4,NM_175875.4:c.803+93C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,8.941,\N,\N,SIX5
418888,19:46271237:A>G,46271237,NM_175875.4,NM_175875.4:c.803+63T>C,\N,\N,\N,1/2,Benign,\N,intron_variant,MODIFIER,\N,\N,7.626,0.0159,1KG_EUR_AF,SIX5
418889,19:46271244:C>T,46271244,NM_175875.4,NM_175875.4:c.803+56G>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,8.984,0.0015,1KG_AFR_AF,SIX5
418890,19:46271253:G>T,46271253,NM_175875.4,NM_175875.4:c.803+47C>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,6.72,0.0000221946,EXAC_NFE_AF,SIX5
418891,19:46271255:G>T,46271255,NM_175875.4,NM_175875.4:c.803+45C>A,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,5.471,0.0000220673,EXAC_NFE_AF,SIX5
418892,19:46271264:G>A,46271264,NM_175875.4,NM_175875.4:c.803+36C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,5.189,0.000180963,EXAC_AFR_AF,SIX5
418893,19:46271266:G>A,46271266,NM_175875.4,NM_175875.4:c.803+34C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,6.997,0.000152952,EXAC_EAS_AF,SIX5
418894,19:46271270:G>A,46271270,NM_175875.4,NM_175875.4:c.803+30C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,7.487,0.000177873,EXAC_AFR_AF,SIX5
418895,19:46271272:T>C,46271272,NM_175875.4,NM_175875.4:c.803+28A>G,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,1.679,0.0000214445,EXAC_NFE_AF,SIX5
418896,19:46271273:G>A,46271273,NM_175875.4,NM_175875.4:c.803+27C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,7.46,0.0000214335,EXAC_NFE_AF,SIX5
418897,19:46271278:T>TG,46271278,NM_175875.4,NM_175875.4:c.803+21dup,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,0.837,0.000175685,EXAC_AFR_AF,SIX5
418898,19:46271279:G>A,46271279,NM_175875.4,NM_175875.4:c.803+21C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,2.647,0.001,1KG_EAS_AF,SIX5
418899,19:46271281:G>A,46271281,NM_175875.4,NM_175875.4:c.803+19C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,1.506,0.0000740302,EXAC_SAS_AF,SIX5
418900,19:46271284:G>A,46271284,NM_175875.4,NM_175875.4:c.803+16C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,2.446,0.001,1KG_EUR_AF,SIX5
418901,19:46271291:G>A,46271291,NM_175875.4,NM_175875.4:c.803+9C>T,\N,\N,\N,1/2,Unknown significance,\N,intron_variant,MODIFIER,\N,\N,8.859,0.0000203136,EXAC_NFE_AF,SIX5
418902,19:46271292:C>T,46271292,NM_175875.4,NM_175875.4:c.803+8G>A,\N,\N,\N,1/2,Unknown significance,\N,splice_region_variant&intron_variant,LOW,\N,\N,11.46,0.0000202077,EXAC_NFE_AF,SIX5
418903,19:46271293:C>T,46271293,NM_175875.4,NM_175875.4:c.803+7G>A,\N,\N,\N,1/2,Unknown significance,\N,splice_region_variant&intron_variant,LOW,\N,\N,13.02,0.000283447,EXAC_EAS_AF,SIX5
418904,19:46271308:G>A,46271308,NM_175875.4,NM_175875.4:c.795C>T,NP_787071.2:p.Pro265=,265,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.94,0.00013312,EXAC_EAS_AF,SIX5
418905,19:46271309:G>C,46271309,NM_175875.4,NM_175875.4:c.794C>G,NP_787071.2:p.Pro265Arg,265,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,16.97,0.000018728,EXAC_NFE_AF,SIX5
418906,19:46271323:G>A,46271323,NM_175875.4,NM_175875.4:c.780C>T,NP_787071.2:p.Ala260=,260,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.844,0.001,1KG_EAS_AF,SIX5
418907,19:46271325:C>G,46271325,NM_175875.4,NM_175875.4:c.778G>C,NP_787071.2:p.Ala260Pro,260,1/3,\N,Likely benign,\N,missense_variant,MODERATE,Homeobox domain,\N,19.86,\N,\N,SIX5
418908,19:46271329:G>A,46271329,NM_175875.4,NM_175875.4:c.774C>T,NP_787071.2:p.Thr258=,258,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,14.49,0.0000650787,EXAC_SAS_AF,SIX5
418909,19:46271338:G>GCGCTGT,46271338,NM_175875.4,NM_175875.4:c.759_764dup,NP_787071.2:p.Gln254_Arg255dup,255,1/3,\N,Unknown significance,\N,inframe_insertion,MODERATE,\N,\N,14.74,\N,\N,SIX5
418910,19:46271339:C>T,46271339,NM_175875.4,NM_175875.4:c.764G>A,NP_787071.2:p.Arg255His,255,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeobox| conserved site;Homeodomain-like,\N,33,0.0000172485,EXAC_NFE_AF,SIX5
418911,19:46271362:G>A,46271362,NM_175875.4,NM_175875.4:c.741C>T,NP_787071.2:p.Asn247=,247,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,15.13,0.000125125,EXAC_SAS_AF,SIX5
418912,19:46271371:C>T,46271371,NM_175875.4,NM_175875.4:c.732G>A,NP_787071.2:p.Gln244=,244,1/3,\N,Benign,\N,synonymous_variant,LOW,\N,\N,15.39,0.00500466,EVS_EA_AF,SIX5
418913,19:46271381:G>A,46271381,NM_175875.4,NM_175875.4:c.722C>T,NP_787071.2:p.Ser241Leu,241,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeobox| conserved site;Homeodomain-like,\N,31,0.000116414,EVS_EA_AF,SIX5
418914,19:46271383:C>T,46271383,NM_175875.4,NM_175875.4:c.720G>A,NP_787071.2:p.Leu240=,240,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,14.69,0.0000165366,EXAC_NFE_AF,SIX5
418915,19:46271385:G>A,46271385,NM_175875.4,NM_175875.4:c.718C>T,NP_787071.2:p.Leu240=,240,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,15.43,0.0000165027,EXAC_NFE_AF,SIX5
418916,19:46271388:C>T,46271388,NM_175875.4,NM_175875.4:c.715G>A,NP_787071.2:p.Gly239Ser,239,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeobox| conserved site;Homeodomain-like,\N,33,\N,\N,SIX5
418917,19:46271389:G>C,46271389,NM_175875.4,NM_175875.4:c.714C>G,NP_787071.2:p.Thr238=,238,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.04,0.000234137,EXAC_AFR_AF,SIX5
418918,19:46271392:G>A,46271392,NM_175875.4,NM_175875.4:c.711C>T,NP_787071.2:p.Leu237=,237,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.5,0.000116387,EVS_EA_AF,SIX5
418919,19:46271393:AGT>A,46271393,NM_175875.4,NM_175875.4:c.708_709del,NP_787071.2:p.Leu237HisfsTer34,236-237,1/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,29.4,0.0000164712,EXAC_NFE_AF,SIX5
418920,19:46271395:T>C,46271395,NM_175875.4,NM_175875.4:c.708A>G,NP_787071.2:p.Thr236=,236,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.28,0.0000164614,EXAC_NFE_AF,SIX5
418921,19:46271397:T>C,46271397,NM_175875.4,NM_175875.4:c.706A>G,NP_787071.2:p.Thr236Ala,236,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeobox| conserved site;Homeodomain-like,\N,18.19,0.003,1KG_EAS_AF,SIX5
418922,19:46271405:C>T,46271405,NM_175875.4,NM_175875.4:c.698G>A,NP_787071.2:p.Arg233His,233,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,26.5,0.0000624766,EXAC_SAS_AF,SIX5
418923,19:46271406:G>A,46271406,NM_175875.4,NM_175875.4:c.697C>T,NP_787071.2:p.Arg233Cys,233,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,32,0.000016415,EXAC_NFE_AF,SIX5
418924,19:46271408:C>T,46271408,NM_175875.4,NM_175875.4:c.695G>A,NP_787071.2:p.Arg232His,232,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,33,0.0000912742,EXAC_AMR_AF,SIX5
418925,19:46271416:G>A,46271416,NM_175875.4,NM_175875.4:c.687C>T,NP_787071.2:p.Asp229=,229,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.994,0.0000163249,EXAC_NFE_AF,SIX5
418926,19:46271416:G>C,46271416,NM_175875.4,NM_175875.4:c.687C>G,NP_787071.2:p.Asp229Glu,229,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,22.9,0.00011343,EXAC_AFR_AF,SIX5
418927,19:46271416:G>T,46271416,NM_175875.4,NM_175875.4:c.687C>A,NP_787071.2:p.Asp229Glu,229,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,23,0.000232721,EVS_EA_AF,SIX5
418928,19:46271432:C>G,46271432,NM_175875.4,NM_175875.4:c.671G>C,NP_787071.2:p.Arg224Pro,224,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,26.9,0.000243368,EXAC_EAS_AF,SIX5
418929,19:46271435:T>C,46271435,NM_175875.4,NM_175875.4:c.668A>G,NP_787071.2:p.Asn223Ser,223,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,23.5,0.0000161765,EXAC_NFE_AF,SIX5
418930,19:46271452:C>G,46271452,NM_175875.4,NM_175875.4:c.651G>C,NP_787071.2:p.Lys217Asn,217,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,26.8,0.000125408,EXAC_SAS_AF,SIX5
418931,19:46271454:T>A,46271454,NM_175875.4,NM_175875.4:c.649A>T,NP_787071.2:p.Lys217Ter,217,1/3,\N,Unknown significance,\N,stop_gained,HIGH,Homeobox domain;Homeodomain-like,\N,36,0.0000161943,EXAC_NFE_AF,SIX5
418932,19:46271467:G>A,46271467,NM_175875.4,NM_175875.4:c.636C>T,NP_787071.2:p.Ser212=,212,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.976,0.000116306,EVS_EA_AF,SIX5
418933,19:46271468:G>C,46271468,NM_175875.4,NM_175875.4:c.635C>G,NP_787071.2:p.Ser212Cys,212,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,25.8,0.0000162745,EXAC_NFE_AF,SIX5
418934,19:46271475:C>T,46271475,NM_175875.4,NM_175875.4:c.628G>A,NP_787071.2:p.Glu210Lys,210,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,32,0.000188466,EXAC_AMR_AF,SIX5
418935,19:46271479:G>A,46271479,NM_175875.4,NM_175875.4:c.624C>T,NP_787071.2:p.Phe208=,208,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.05,0.00272356,EVS_AA_AF,SIX5
418936,19:46271482:G>T,46271482,NM_175875.4,NM_175875.4:c.621C>A,NP_787071.2:p.Cys207Ter,207,1/3,\N,Unknown significance,\N,stop_gained,HIGH,Homeobox domain;Homeodomain-like,\N,37,\N,\N,SIX5
418937,19:46271486:T>C,46271486,NM_175875.4,NM_175875.4:c.617A>G,NP_787071.2:p.Tyr206Cys,206,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,24.9,\N,\N,SIX5
418938,19:46271490:C>T,46271490,NM_175875.4,NM_175875.4:c.613G>A,NP_787071.2:p.Val205Ile,205,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,23.8,0.00068089,EVS_AA_AF,SIX5
418939,19:46271493:T>C,46271493,NM_175875.4,NM_175875.4:c.610A>G,NP_787071.2:p.Thr204Ala,204,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,Homeobox domain;Homeodomain-like,\N,22.3,0.000195925,EXAC_FIN_AF,SIX5
418940,19:46271494:C>T,46271494,NM_175875.4,NM_175875.4:c.609G>A,NP_787071.2:p.Glu203=,203,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.92,0.000129049,EXAC_SAS_AF,SIX5
418941,19:46271497:C>T,46271497,NM_175875.4,NM_175875.4:c.606G>A,NP_787071.2:p.Glu202=,202,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.1,0.000097144,EXAC_AMR_AF,SIX5
418942,19:46271500:G>A,46271500,NM_175875.4,NM_175875.4:c.603C>T,NP_787071.2:p.Gly201=,201,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.68,0.001,1KG_EAS_AF,SIX5
418943,19:46271503:G>A,46271503,NM_175875.4,NM_175875.4:c.600C>T,NP_787071.2:p.Asp200=,200,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.345,0.000116279,EVS_EA_AF,SIX5
418944,19:46271512:G>A,46271512,NM_175875.4,NM_175875.4:c.591C>T,NP_787071.2:p.Thr197=,197,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,9.935,0.000226963,EVS_AA_AF,SIX5
418945,19:46271515:C>T,46271515,NM_175875.4,NM_175875.4:c.588G>A,NP_787071.2:p.Lys196=,196,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.35,0.0000170085,EXAC_NFE_AF,SIX5
418946,19:46271517:T>G,46271517,NM_175875.4,NM_175875.4:c.586A>C,NP_787071.2:p.Lys196Gln,196,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25,0.00010004,EXAC_AMR_AF,SIX5
418947,19:46271518:G>A,46271518,NM_175875.4,NM_175875.4:c.585C>T,NP_787071.2:p.Pro195=,195,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.947,0.0000171004,EXAC_NFE_AF,SIX5
418948,19:46271518:G>C,46271518,NM_175875.4,NM_175875.4:c.585C>G,NP_787071.2:p.Pro195=,195,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,3.23,0.000115929,EXAC_AFR_AF,SIX5
418949,19:46271519:G>A,46271519,NM_175875.4,NM_175875.4:c.584C>T,NP_787071.2:p.Pro195Leu,195,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,27.5,0.0000656858,EXAC_SAS_AF,SIX5
418950,19:46271520:G>A,46271520,NM_175875.4,NM_175875.4:c.583C>T,NP_787071.2:p.Pro195Ser,195,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,26.1,\N,\N,SIX5
418951,19:46271523:G>A,46271523,NM_175875.4,NM_175875.4:c.580C>T,NP_787071.2:p.Leu194=,194,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.263,0.0000658241,EXAC_SAS_AF,SIX5
418952,19:46271525:G>A,46271525,NM_175875.4,NM_175875.4:c.578C>T,NP_787071.2:p.Pro193Leu,193,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,30,0.000423191,EXAC_FIN_AF,SIX5
418953,19:46271527:G>A,46271527,NM_175875.4,NM_175875.4:c.576C>T,NP_787071.2:p.Phe192=,192,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.505,0.0027248,EXAC_OTH_AF,SIX5
418954,19:46271531:T>C,46271531,NM_175875.4,NM_175875.4:c.572A>G,NP_787071.2:p.Lys191Arg,191,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.3,0.0000175809,EXAC_NFE_AF,SIX5
418955,19:46271533:C>T,46271533,NM_175875.4,NM_175875.4:c.570G>A,NP_787071.2:p.Lys190=,190,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.51,0.0000177387,EXAC_NFE_AF,SIX5
418956,19:46271536:G>C,46271536,NM_175875.4,NM_175875.4:c.567C>G,NP_787071.2:p.Arg189=,189,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,3.282,0.000226963,EVS_AA_AF,SIX5
418957,19:46271537:C>T,46271537,NM_175875.4,NM_175875.4:c.566G>A,NP_787071.2:p.Arg189His,189,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,33,\N,\N,SIX5
418958,19:46271545:A>G,46271545,NM_175875.4,NM_175875.4:c.558T>C,NP_787071.2:p.Tyr186=,186,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.058,0.000111334,EXAC_AMR_AF,SIX5
418959,19:46271554:C>T,46271554,NM_175875.4,NM_175875.4:c.549G>A,NP_787071.2:p.Val183=,183,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.48,0.00384106,EXAC_AFR_AF,SIX5
418960,19:46271560:G>T,46271560,NM_175875.4,NM_175875.4:c.543C>A,NP_787071.2:p.Gly181=,181,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.34,0.000843645,EXAC_AFR_AF,SIX5
418961,19:46271566:C>A,46271566,NM_175875.4,NM_175875.4:c.537G>T,NP_787071.2:p.Ala179=,179,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,21.7,\N,\N,SIX5
418962,19:46271567:G>T,46271567,NM_175875.4,NM_175875.4:c.536C>A,NP_787071.2:p.Ala179Glu,179,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,27.3,0.0000733676,EXAC_SAS_AF,SIX5
418963,19:46271568:C>G,46271568,NM_175875.4,NM_175875.4:c.535G>C,NP_787071.2:p.Ala179Pro,179,1/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,12.88,0.0000221661,EXAC_NFE_AF,SIX5
418964,19:46271572:G>A,46271572,NM_175875.4,NM_175875.4:c.531C>T,NP_787071.2:p.Gly177=,177,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.857,0.00098912,EXAC_EAS_AF,SIX5
418965,19:46271575:G>A,46271575,NM_175875.4,NM_175875.4:c.528C>T,NP_787071.2:p.Arg176=,176,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.74,0.0000469528,EXAC_NFE_AF,SIX5
418966,19:46271577:G>A,46271577,NM_175875.4,NM_175875.4:c.526C>T,NP_787071.2:p.Arg176Cys,176,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,34,0.000227894,EVS_AA_AF,SIX5
418967,19:46271581:C>T,46271581,NM_175875.4,NM_175875.4:c.522G>A,NP_787071.2:p.Arg174=,174,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,14.37,0.0000248583,EXAC_NFE_AF,SIX5
418968,19:46271593:A>T,46271593,NM_175875.4,NM_175875.4:c.510T>A,NP_787071.2:p.His170Gln,170,1/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,7.63,\N,\N,SIX5
418969,19:46271594:T>A,46271594,NM_175875.4,NM_175875.4:c.509A>T,NP_787071.2:p.His170Leu,170,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,15.82,0.00212766,EXAC_OTH_AF,SIX5
418970,19:46271595:G>A,46271595,NM_175875.4,NM_175875.4:c.508C>T,NP_787071.2:p.His170Tyr,170,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,12.58,0.000179469,EXAC_AMR_AF,SIX5
418971,19:46271598:AGC>A,46271598,NM_175875.4,NM_175875.4:c.503_504del,NP_787071.2:p.Arg168LeufsTer3,168,1/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,34,\N,\N,SIX5
418972,19:46271609:A>G,46271609,NM_175875.4,NM_175875.4:c.494T>C,NP_787071.2:p.Leu165Pro,165,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.6,0.0000314169,EXAC_NFE_AF,SIX5
418973,19:46271610:G>A,46271610,NM_175875.4,NM_175875.4:c.493C>T,NP_787071.2:p.Leu165=,165,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,6.716,0.0031,1KG_SAS_AF,SIX5
418974,19:46271610:G>C,46271610,NM_175875.4,NM_175875.4:c.493C>G,NP_787071.2:p.Leu165Val,165,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.7,0.0000853242,EXAC_SAS_AF,SIX5
418975,19:46271611:G>A,46271611,NM_175875.4,NM_175875.4:c.492C>T,NP_787071.2:p.Tyr164=,164,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,3.28,0.00097371,EXAC_AFR_AF,SIX5
418976,19:46271617:G>A,46271617,NM_175875.4,NM_175875.4:c.486C>T,NP_787071.2:p.Asp162=,162,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,5.842,0.000257865,EXAC_AFR_AF,SIX5
418977,19:46271618:TC>T,46271618,NM_175875.4,NM_175875.4:c.484del,NP_787071.2:p.Asp162ThrfsTer162,162,1/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,26.9,0.0000333868,EXAC_NFE_AF,SIX5
418978,19:46271626:G>A,46271626,NM_175875.4,NM_175875.4:c.477C>T,NP_787071.2:p.Phe159=,159,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,7.901,0.001,1KG_EAS_AF,SIX5
418979,19:46271631:C>T,46271631,NM_175875.4,NM_175875.4:c.472G>A,NP_787071.2:p.Ala158Thr,158,1/3,\N,Pathogenic,Branchio-oto-renal syndrome,missense_variant,MODERATE,\N,\N,22.4,0.00036452,EVS_EA_AF,SIX5
418980,19:46271632:G>A,46271632,NM_175875.4,NM_175875.4:c.471C>T,NP_787071.2:p.His157=,157,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,8.888,0.000038838,EXAC_NFE_AF,SIX5
418981,19:46271639:G>C,46271639,NM_175875.4,NM_175875.4:c.464C>G,NP_787071.2:p.Ala155Gly,155,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.2,\N,\N,SIX5
418982,19:46271646:G>A,46271646,NM_175875.4,NM_175875.4:c.457C>T,NP_787071.2:p.Pro153Ser,153,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,12.9,\N,\N,SIX5
418983,19:46271650:G>A,46271650,NM_175875.4,NM_175875.4:c.453C>T,NP_787071.2:p.Pro151=,151,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.81,0.0000506534,EXAC_NFE_AF,SIX5
418984,19:46271650:G>C,46271650,NM_175875.4,NM_175875.4:c.453C>G,NP_787071.2:p.Pro151=,151,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.27,0,EXAC_ALL_AF|EXAC_AFR_AF|EXAC_AMR_AF|EXAC_EAS_AF|EXAC_FIN_AF|EXAC_NFE_AF|EXAC_OTH_AF|EXAC_SAS_AF,SIX5
418985,19:46271659:C>G,46271659,NM_175875.4,NM_175875.4:c.444G>C,NP_787071.2:p.Glu148Asp,148,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.8,0.000108249,EXAC_SAS_AF,SIX5
418986,19:46271661:CG>C,46271661,NM_175875.4,NM_175875.4:c.441del,NP_787071.2:p.Glu148ArgfsTer176,147,1/3,\N,Unknown significance,\N,frameshift_variant,HIGH,\N,\N,23.4,\N,\N,SIX5
418987,19:46271662:G>A,46271662,NM_175875.4,NM_175875.4:c.441C>T,NP_787071.2:p.Leu147=,147,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.38,0.001,1KG_EAS_AF|1KG_SAS_AF,SIX5
418988,19:46271662:G>T,46271662,NM_175875.4,NM_175875.4:c.441C>A,NP_787071.2:p.Leu147=,147,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.69,0.0000701459,EXAC_NFE_AF,SIX5
418989,19:46271664:G>T,46271664,NM_175875.4,NM_175875.4:c.439C>A,NP_787071.2:p.Leu147Ile,147,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23,\N,\N,SIX5
418990,19:46271667:G>A,46271667,NM_175875.4,NM_175875.4:c.436C>T,NP_787071.2:p.Leu146=,146,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,14.02,0.000681199,EXAC_AMR_AF,SIX5
418991,19:46271670:G>C,46271670,NM_175875.4,NM_175875.4:c.433C>G,NP_787071.2:p.Arg145Gly,145,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,22,0.000877193,EXAC_AMR_AF,SIX5
418992,19:46271674:G>A,46271674,NM_175875.4,NM_175875.4:c.429C>T,NP_787071.2:p.Leu143=,143,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,14.21,0.000104362,EXAC_NFE_AF,SIX5
418993,19:46271680:G>C,46271680,NM_175875.4,NM_175875.4:c.423C>G,NP_787071.2:p.Ala141=,141,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.36,0.000138581,EXAC_NFE_AF,SIX5
418994,19:46271682:C>T,46271682,NM_175875.4,NM_175875.4:c.421G>A,NP_787071.2:p.Ala141Thr,141,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25,0.000154655,EXAC_NFE_AF,SIX5
418995,19:46271683:G>A,46271683,NM_175875.4,NM_175875.4:c.420C>T,NP_787071.2:p.Tyr140=,140,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,13.64,0.000126454,EXAC_SAS_AF,SIX5
418996,19:46271685:A>G,46271685,NM_175875.4,NM_175875.4:c.418T>C,NP_787071.2:p.Tyr140His,140,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.3,\N,\N,SIX5
418997,19:46271704:C>A,46271704,NM_175875.4,NM_175875.4:c.399G>T,NP_787071.2:p.Val133=,133,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,14.72,\N,\N,SIX5
418998,19:46271713:C>T,46271713,NM_175875.4,NM_175875.4:c.390G>A,NP_787071.2:p.Arg130=,130,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,16.12,\N,\N,SIX5
418999,19:46271716:C>G,46271716,NM_175875.4,NM_175875.4:c.387G>C,NP_787071.2:p.Ala129=,129,1/3,\N,Benign,\N,synonymous_variant,LOW,\N,\N,14.4,0.00561798,EXAC_EAS_AF,SIX5
419000,19:46271728:C>G,46271728,NM_175875.4,NM_175875.4:c.375G>C,NP_787071.2:p.Pro125=,125,1/3,\N,Benign,\N,synonymous_variant,LOW,\N,\N,13.79,0.029703,EXAC_AFR_AF,SIX5
419001,19:46271737:G>A,46271737,NM_175875.4,NM_175875.4:c.366C>T,NP_787071.2:p.Gly122=,122,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.23,\N,\N,SIX5
419002,19:46271758:G>A,46271758,NM_175875.4,NM_175875.4:c.345C>T,NP_787071.2:p.Pro115=,115,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,0.705,0.0008,1KG_AFR_AF,SIX5
419003,19:46271803:C>T,46271803,NM_175875.4,NM_175875.4:c.300G>A,NP_787071.2:p.Gln100=,100,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,4.304,\N,\N,SIX5
419004,19:46271849:C>A,46271849,NM_175875.4,NM_175875.4:c.254G>T,NP_787071.2:p.Arg85Leu,85,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,25.9,0.001,1KG_EAS_AF,SIX5
419005,19:46271890:C>A,46271890,NM_175875.4,NM_175875.4:c.213G>T,NP_787071.2:p.Gly71=,71,1/3,\N,Benign,\N,synonymous_variant,LOW,\N,\N,12.52,0.0204,1KG_AFR_AF,SIX5
419006,19:46271928:C>G,46271928,NM_175875.4,NM_175875.4:c.175G>C,NP_787071.2:p.Ala59Pro,59,1/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,13.91,\N,\N,SIX5
419007,19:46271941:C>CGCCCCG,46271941,NM_175875.4,NM_175875.4:c.156_161dup,NP_787071.2:p.Gly55_Ala56dup,54,1/3,\N,Unknown significance,\N,inframe_insertion,MODERATE,\N,\N,15.42,0.0023,1KG_AFR_AF,SIX5
419008,19:46271953:GGCC>G,46271953,NM_175875.4,NM_175875.4:c.147_149del,NP_787071.2:p.Ala50del,49-50,1/3,\N,Unknown significance,\N,inframe_deletion,MODERATE,\N,\N,13.94,\N,\N,SIX5
419009,19:46271995:C>T,46271995,NM_175875.4,NM_175875.4:c.108G>A,NP_787071.2:p.Leu36=,36,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,10.03,0.0029,1KG_AMR_AF,SIX5
419010,19:46272030:T>TCGC,46272030,NM_175875.4,NM_175875.4:c.70_72dup,NP_787071.2:p.Ala24dup,24-25,1/3,\N,Unknown significance,\N,inframe_insertion,MODERATE,\N,\N,\N,\N,\N,SIX5
419011,19:46272030:TCGC>T,46272030,NM_175875.4,NM_175875.4:c.70_72del,NP_787071.2:p.Ala24del,24,1/3,\N,Unknown significance,\N,inframe_deletion,MODERATE,\N,\N,15.87,\N,\N,SIX5
419012,19:46272030:TCGCCGCCGC>T,46272030,NM_175875.4,NM_175875.4:c.64_72del,NP_787071.2:p.Ala22_Ala24del,22-24,1/3,\N,Unknown significance,\N,inframe_deletion,MODERATE,\N,\N,15.26,\N,\N,SIX5
419013,19:46272047:A>G,46272047,NM_175875.4,NM_175875.4:c.56T>C,NP_787071.2:p.Val19Ala,19,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,12.84,0.000393701,EXAC_NFE_AF,SIX5
419014,19:46272050:G>T,46272050,NM_175875.4,NM_175875.4:c.53C>A,NP_787071.2:p.Ala18Glu,18,1/3,\N,Likely benign,\N,missense_variant,MODERATE,\N,\N,10.08,0.000136463,EXAC_SAS_AF,SIX5
419015,19:46272058:C>A,46272058,NM_175875.4,NM_175875.4:c.45G>T,NP_787071.2:p.Gly15=,15,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,12.11,0.0014,1KG_AMR_AF,SIX5
419016,19:46272058:C>T,46272058,NM_175875.4,NM_175875.4:c.45G>A,NP_787071.2:p.Gly15=,15,1/3,\N,Unknown significance,\N,synonymous_variant,LOW,\N,\N,11.99,0.00040783,EXAC_SAS_AF,SIX5
419017,19:46272059:C>A,46272059,NM_175875.4,NM_175875.4:c.44G>T,NP_787071.2:p.Gly15Val,15,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,14.65,0.001,1KG_SAS_AF,SIX5
419018,19:46272071:CCCGCGCTCGGCT>C,46272071,NM_175875.4,NM_175875.4:c.20_31del,NP_787071.2:p.Glu7_Ala10del,7-11,1/3,\N,Unknown significance,\N,inframe_deletion,MODERATE,\N,\N,13.27,\N,\N,SIX5
419019,19:46272089:G>A,46272089,NM_175875.4,NM_175875.4:c.14C>T,NP_787071.2:p.Pro5Leu,5,1/3,\N,Unknown significance,\N,missense_variant,MODERATE,\N,\N,23.2,0.00013369,EXAC_SAS_AF,SIX5
419020,19:46272109:C>T,46272109,NM_175875.4,NM_175875.4:c.-7G>A,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,13.19,0.0015,1KG_AFR_AF,SIX5
419021,19:46272123:TCCTCCCTC>T,46272123,NM_175875.4,NM_175875.4:c.-29_-22del,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,\N,\N,\N,SIX5
419022,19:46272124:C>T,46272124,NM_175875.4,NM_175875.4:c.-22G>A,\N,\N,1/3,\N,Benign,\N,5_prime_UTR_variant,MODIFIER,\N,\N,13.8,0.0058,1KG_AMR_AF,SIX5
419023,19:46272128:C>A,46272128,NM_175875.4,NM_175875.4:c.-26G>T,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,15.12,0.000369276,EXAC_NFE_AF,SIX5
419024,19:46272128:C>T,46272128,NM_175875.4,NM_175875.4:c.-26G>A,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,14.72,0.000369276,EXAC_NFE_AF,SIX5
419025,19:46272132:C>T,46272132,NM_175875.4,NM_175875.4:c.-30G>A,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,13.71,\N,\N,SIX5
419026,19:46272144:C>T,46272144,NM_175875.4,NM_175875.4:c.-42G>A,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,14.36,0.000133726,EXAC_SAS_AF,SIX5
419027,19:46272145:C>T,46272145,NM_175875.4,NM_175875.4:c.-43G>A,\N,\N,1/3,\N,Benign,\N,5_prime_UTR_variant,MODIFIER,\N,\N,13.81,0.00520833,EXAC_AFR_AF,SIX5
419028,19:46272147:C>T,46272147,NM_175875.4,NM_175875.4:c.-45G>A,\N,\N,1/3,\N,Benign,\N,5_prime_UTR_variant,MODIFIER,\N,\N,11.1,0.0166,1KG_AFR_AF,SIX5
419029,19:46272161:C>T,46272161,NM_175875.4,NM_175875.4:c.-59G>A,\N,\N,1/3,\N,Benign,\N,5_prime_UTR_variant,MODIFIER,\N,\N,12.59,0.0174,1KG_AFR_AF,SIX5
419030,19:46272162:C>T,46272162,NM_175875.4,NM_175875.4:c.-60G>A,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,13.31,0.0008,1KG_AFR_AF,SIX5
419031,19:46272177:T>TC,46272177,NM_175875.4,NM_175875.4:c.-76dup,\N,\N,1/3,\N,Benign,\N,5_prime_UTR_variant,MODIFIER,\N,\N,9.518,0.1195,1KG_AFR_AF,SIX5
419032,19:46272210:C>A,46272210,NM_175875.4,NM_175875.4:c.-108G>T,\N,\N,1/3,\N,Benign,\N,5_prime_UTR_variant,MODIFIER,\N,\N,1.729,0.0159,1KG_AFR_AF,SIX5
419033,19:46272230:C>G,46272230,NM_175875.4,NM_175875.4:c.-128G>C,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,0.083,0.001,1KG_EUR_AF,SIX5
419034,19:46272244:C>A,46272244,NM_175875.4,NM_175875.4:c.-142G>T,\N,\N,1/3,\N,Benign,\N,5_prime_UTR_variant,MODIFIER,\N,\N,2.272,0.0098,1KG_AFR_AF,SIX5
419035,19:46272250:G>A,46272250,NM_175875.4,NM_175875.4:c.-148C>T,\N,\N,1/3,\N,Benign,\N,5_prime_UTR_variant,MODIFIER,\N,\N,0.138,0.1415,1KG_AFR_AF,SIX5
419036,19:46272265:T>C,46272265,NM_175875.4,NM_175875.4:c.-163A>G,\N,\N,1/3,\N,Benign,\N,5_prime_UTR_variant,MODIFIER,\N,\N,6.218,0.0469,1KG_AFR_AF,SIX5
419037,19:46272269:C>T,46272269,NM_175875.4,NM_175875.4:c.-167G>A,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,7.888,\N,\N,SIX5
419038,19:46272283:C>T,46272283,NM_175875.4,NM_175875.4:c.-181G>A,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,12.11,0.0008,1KG_AFR_AF,SIX5
419039,19:46272301:C>A,46272301,NM_175875.4,NM_175875.4:c.-199G>T,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,10.39,0.002,1KG_SAS_AF,SIX5
419040,19:46272308:C>T,46272308,NM_175875.4,NM_175875.4:c.-206G>A,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,10.04,\N,\N,SIX5
419041,19:46272313:G>A,46272313,NM_175875.4,NM_175875.4:c.-211C>T,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,12.42,0.001,1KG_SAS_AF,SIX5
419042,19:46272366:C>T,46272366,NM_175875.4,NM_175875.4:c.-264G>A,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,15.2,0.001,1KG_EAS_AF,SIX5
419043,19:46272398:G>A,46272398,NM_175875.4,NM_175875.4:c.-296C>T,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,13.2,\N,\N,SIX5
419044,19:46272403:C>T,46272403,NM_175875.4,NM_175875.4:c.-301G>A,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,15.29,0.001,1KG_EAS_AF,SIX5
419045,19:46272407:T>A,46272407,NM_175875.4,NM_175875.4:c.-305A>T,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,14.48,0.001,1KG_SAS_AF,SIX5
419046,19:46272408:C>G,46272408,NM_175875.4,NM_175875.4:c.-306G>C,\N,\N,1/3,\N,Benign,\N,5_prime_UTR_variant,MODIFIER,\N,\N,13.78,0.0082,1KG_SAS_AF,SIX5
419047,19:46272436:C>A,46272436,NM_175875.4,NM_175875.4:c.-334G>T,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,14.42,0.0015,1KG_AFR_AF,SIX5
419048,19:46272463:C>G,46272463,NM_175875.4,NM_175875.4:c.-361G>C,\N,\N,1/3,\N,Unknown significance,\N,5_prime_UTR_variant,MODIFIER,\N,\N,6.266,\N,\N,SIX