id,variation,vep_hgvs_c,vep_hgvs_p,vep_exon,vep_intron,final_pathogenicity,final_disease,vep_consequence,vep_cadd_phred,overall_max_maf,overall_max_maf_source,gene
612747,4:6271599:G>T,NM_006005.3:c.-148G>T,\N,1/8,\N,Unknown significance,\N,5_prime_UTR_variant,5.918,0.0015,1KG_AFR_AF,WFS1
612748,4:6271606:A>G,NM_006005.3:c.-141A>G,\N,1/8,\N,Benign,\N,5_prime_UTR_variant,4.8,0.0125,OTO_JP_AF,WFS1
612749,4:6271617:C>T,NM_006005.3:c.-130C>T,\N,1/8,\N,Unknown significance,\N,5_prime_UTR_variant,9.043,0.004,1KG_EUR_AF,WFS1
612750,4:6271620:A>G,NM_006005.3:c.-127A>G,\N,1/8,\N,Unknown significance,\N,5_prime_UTR_variant,3.668,0.0038,1KG_AFR_AF,WFS1
612751,4:6271623:G>T,NM_006005.3:c.-124G>T,\N,1/8,\N,Benign,\N,5_prime_UTR_variant,4.153,0.0079,1KG_EAS_AF,WFS1
612752,4:6271627:C>T,NM_006005.3:c.-120C>T,\N,1/8,\N,Unknown significance,\N,5_prime_UTR_variant,8.865,\N,\N,WFS1
612753,4:6271662:C>G,NM_006005.3:c.-85C>G,\N,1/8,\N,Unknown significance,\N,5_prime_UTR_variant,7.244,\N,\N,WFS1
612754,4:6271665:C>T,NM_006005.3:c.-82C>T,\N,1/8,\N,Unknown significance,\N,5_prime_UTR_variant,8.346,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
612755,4:6271720:C>T,NM_006005.3:c.-27C>T,\N,1/8,\N,Unknown significance,\N,5_prime_UTR_variant,11.77,0.0008,1KG_AFR_AF,WFS1
612756,4:6271752:C>T,NM_006005.3:c.-6+11C>T,\N,\N,1/7,Benign,\N,intron_variant,7.537,0.0136,1KG_AFR_AF,WFS1
612757,4:6271766:T>C,NM_006005.3:c.-6+25T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,5.79,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
612758,4:6271767:G>GGCGCGGTGGCTGTGGGCA,NM_006005.3:c.-6+32_-6+49dup,\N,\N,1/7,Benign,\N,intron_variant,4.405,0.3752,1KG_AFR_AF,WFS1
612759,4:6271767:G>GGGCA,NM_006005.3:c.-6+27_-6+28insGCAG,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
612760,4:6271767:G>A,NM_006005.3:c.-6+26G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.526,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
612761,4:6271769:C>A,NM_006005.3:c.-6+28C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,10.76,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
612762,4:6271777:C>A,NM_006005.3:c.-6+36C>A,\N,\N,1/7,Benign,\N,intron_variant,10.72,0.0139,1KG_EAS_AF,WFS1
612763,4:6271826:T>C,NM_006005.3:c.-6+85T>C,\N,\N,1/7,Benign,\N,intron_variant,0.908,0.9067,1KG_EAS_AF,WFS1
612764,4:6271848:C>T,NM_006005.3:c.-6+107C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,8.584,\N,\N,WFS1
612765,4:6271893:A>G,NM_006005.3:c.-6+152A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,8.937,\N,\N,WFS1
612766,4:6271905:G>A,NM_006005.3:c.-6+164G>A,\N,\N,1/7,Benign,\N,intron_variant,8.364,0.0091,1KG_AFR_AF,WFS1
612767,4:6271917:C>T,NM_006005.3:c.-6+176C>T,\N,\N,1/7,Benign,\N,intron_variant,5.999,0.0164,1KG_SAS_AF,WFS1
612768,4:6271933:A>C,NM_006005.3:c.-6+192A>C,\N,\N,1/7,Unknown significance,\N,intron_variant,4.868,0.0008,1KG_AFR_AF,WFS1
612769,4:6271958:C>CA,NM_006005.3:c.-6+217_-6+218insA,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
612770,4:6271970:G>C,NM_006005.3:c.-6+229G>C,\N,\N,1/7,Benign,\N,intron_variant,4.991,0.006,1KG_EUR_AF,WFS1
612771,4:6271987:C>T,NM_006005.3:c.-6+246C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,9.584,0.003,1KG_AFR_AF,WFS1
612772,4:6272070:C>T,NM_006005.3:c.-6+329C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,8.51,0.0038,1KG_AFR_AF,WFS1
612773,4:6272071:G>A,NM_006005.3:c.-6+330G>A,\N,\N,1/7,Benign,\N,intron_variant,5.436,0.0356,1KG_AFR_AF,WFS1
612774,4:6272090:C>G,NM_006005.3:c.-6+349C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,6.05,0.004,1KG_EAS_AF,WFS1
612775,4:6272118:G>A,NM_006005.3:c.-6+377G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.135,0.001,1KG_EAS_AF,WFS1
612776,4:6272135:G>C,NM_006005.3:c.-6+394G>C,\N,\N,1/7,Benign,\N,intron_variant,1.369,0.0091,1KG_AFR_AF,WFS1
612777,4:6272142:C>T,NM_006005.3:c.-6+401C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,7.127,\N,\N,WFS1
612778,4:6272153:C>G,NM_006005.3:c.-6+412C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,5.554,\N,\N,WFS1
612779,4:6272155:CG>C,NM_006005.3:c.-6+416del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
612780,4:6272156:G>GGCC,NM_006005.3:c.-6+417_-6+419dup,\N,\N,1/7,Benign,\N,intron_variant,6.662,0.034,1KG_AFR_AF,WFS1
612781,4:6272159:C>T,NM_006005.3:c.-6+418C>T,\N,\N,1/7,Benign,\N,intron_variant,5.08,0.0389,1KG_SAS_AF,WFS1
612782,4:6272193:TG>T,NM_006005.3:c.-6+459del,\N,\N,1/7,Benign,\N,intron_variant,4.02,0.9038,1KG_EAS_AF,WFS1
612783,4:6272208:G>A,NM_006005.3:c.-6+467G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.21,0.0043,1KG_AMR_AF,WFS1
612784,4:6272216:C>A,NM_006005.3:c.-6+475C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,7.871,0.004,1KG_EAS_AF,WFS1
612785,4:6272222:G>A,NM_006005.3:c.-6+481G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.375,0.001,1KG_EAS_AF,WFS1
612786,4:6272229:C>T,NM_006005.3:c.-6+488C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,7.434,0.0014,1KG_AMR_AF,WFS1
612787,4:6272246:A>AC,NM_006005.3:c.-6+505_-6+506insC,\N,\N,1/7,Benign,\N,intron_variant,2.333,0.0219,1KG_AFR_AF,WFS1
612788,4:6272289:C>T,NM_006005.3:c.-6+548C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,6.062,\N,\N,WFS1
612789,4:6272295:C>T,NM_006005.3:c.-6+554C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,7.14,0.001,1KG_EAS_AF,WFS1
612790,4:6272306:T>C,NM_006005.3:c.-6+565T>C,\N,\N,1/7,Benign,\N,intron_variant,2.968,0.9048,1KG_EAS_AF,WFS1
612791,4:6272307:C>T,NM_006005.3:c.-6+566C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.406,0.0015,1KG_AFR_AF,WFS1
612792,4:6272309:C>G,NM_006005.3:c.-6+568C>G,\N,\N,1/7,Benign,\N,intron_variant,4.383,0.0225,1KG_SAS_AF,WFS1
612793,4:6272311:C>T,NM_006005.3:c.-6+570C>T,\N,\N,1/7,Benign,\N,intron_variant,6.306,0.047,1KG_SAS_AF,WFS1
612794,4:6272312:G>A,NM_006005.3:c.-6+571G>A,\N,\N,1/7,Benign,\N,intron_variant,0.054,0.047,1KG_SAS_AF,WFS1
612795,4:6272351:C>G,NM_006005.3:c.-6+610C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,7.164,\N,\N,WFS1
612796,4:6272387:G>A,NM_006005.3:c.-6+646G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.806,\N,\N,WFS1
612797,4:6272437:C>T,NM_006005.3:c.-6+696C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,7.369,0.0008,1KG_AFR_AF,WFS1
612798,4:6272449:A>G,NM_006005.3:c.-6+708A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,5.196,0.0015,1KG_AFR_AF,WFS1
612799,4:6272476:A>T,NM_006005.3:c.-6+735A>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.062,0.004,1KG_EAS_AF,WFS1
612800,4:6272498:T>C,NM_006005.3:c.-6+757T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,7.054,\N,\N,WFS1
612801,4:6272523:C>T,NM_006005.3:c.-6+782C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,6.876,0.001,1KG_EUR_AF,WFS1
612802,4:6272564:G>A,NM_006005.3:c.-6+823G>A,\N,\N,1/7,Benign,\N,intron_variant,5.997,0.0079,1KG_EAS_AF,WFS1
612803,4:6272564:G>T,NM_006005.3:c.-6+823G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.894,\N,\N,WFS1
612804,4:6272574:T>C,NM_006005.3:c.-6+833T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,5.934,0.0014,1KG_AMR_AF,WFS1
612805,4:6272584:T>C,NM_006005.3:c.-6+843T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,6.351,0.0008,1KG_AFR_AF,WFS1
612806,4:6272602:G>C,NM_006005.3:c.-6+861G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,4.282,\N,\N,WFS1
612807,4:6272606:C>A,NM_006005.3:c.-6+865C>A,\N,\N,1/7,Benign,\N,intron_variant,9.39,0.0363,1KG_AFR_AF,WFS1
612808,4:6272635:C>A,NM_006005.3:c.-6+894C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,8.545,0.0038,1KG_AFR_AF,WFS1
612809,4:6272637:C>A,NM_006005.3:c.-6+896C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.59,\N,\N,WFS1
612810,4:6272678:A>C,NM_006005.3:c.-6+937A>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.964,\N,\N,WFS1
612811,4:6272718:G>A,NM_006005.3:c.-6+977G>A,\N,\N,1/7,Benign,\N,intron_variant,14.98,0.9048,1KG_EAS_AF,WFS1
612812,4:6272721:A>G,NM_006005.3:c.-6+980A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,19.65,\N,\N,WFS1
612813,4:6272723:C>G,NM_006005.3:c.-6+982C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,18.75,0.003,1KG_EAS_AF,WFS1
612814,4:6272736:C>T,NM_006005.3:c.-6+995C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,20.9,\N,\N,WFS1
612815,4:6272737:C>G,NM_006005.3:c.-6+996C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,19.89,0.003,1KG_AFR_AF,WFS1
612816,4:6272748:C>T,NM_006005.3:c.-6+1007C>T,\N,\N,1/7,Benign,\N,intron_variant,14.5,0.0144,1KG_AFR_AF,WFS1
612817,4:6272789:C>T,NM_006005.3:c.-6+1048C>T,\N,\N,1/7,Benign,\N,intron_variant,8.289,0.0144,1KG_AFR_AF,WFS1
612818,4:6272803:C>G,NM_006005.3:c.-6+1062C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,6.493,0.001,1KG_EUR_AF,WFS1
612819,4:6272811:C>T,NM_006005.3:c.-6+1070C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,6.889,0.001,1KG_EUR_AF,WFS1
612820,4:6272813:C>A,NM_006005.3:c.-6+1072C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.363,0.001,1KG_EUR_AF,WFS1
612821,4:6272857:G>A,NM_006005.3:c.-6+1116G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.3,\N,\N,WFS1
612822,4:6272888:G>C,NM_006005.3:c.-6+1147G>C,\N,\N,1/7,Benign,\N,intron_variant,2.249,0.998,1KG_EAS_AF,WFS1
612823,4:6272922:A>T,NM_006005.3:c.-6+1181A>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.696,\N,\N,WFS1
612824,4:6272938:C>T,NM_006005.3:c.-6+1197C>T,\N,\N,1/7,Benign,\N,intron_variant,4.725,0.0628,1KG_AFR_AF,WFS1
612825,4:6272957:T>C,NM_006005.3:c.-6+1216T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,3.207,0.002,1KG_EUR_AF,WFS1
612826,4:6272974:C>T,NM_006005.3:c.-6+1233C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.941,\N,\N,WFS1
612827,4:6272986:CT>C,NM_006005.3:c.-6+1246del,\N,\N,1/7,Benign,\N,intron_variant,4.547,0.0295,1KG_AFR_AF,WFS1
612828,4:6272993:C>T,NM_006005.3:c.-6+1252C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,2.921,0.0008,1KG_AFR_AF,WFS1
612829,4:6273019:C>T,NM_006005.3:c.-6+1278C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.633,0.002,1KG_EAS_AF,WFS1
612830,4:6273032:A>G,NM_006005.3:c.-6+1291A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,8.993,0.001,1KG_SAS_AF,WFS1
612831,4:6273043:G>A,NM_006005.3:c.-6+1302G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,13.6,\N,\N,WFS1
612832,4:6273047:AC>A,NM_006005.3:c.-6+1310del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
612833,4:6273058:CCTT>C,NM_006005.3:c.-6+1321_-6+1323del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
612834,4:6273120:C>T,NM_006005.3:c.-6+1379C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,7.022,\N,\N,WFS1
612835,4:6273165:C>T,NM_006005.3:c.-6+1424C>T,\N,\N,1/7,Benign,\N,intron_variant,6.578,0.0144,1KG_AFR_AF,WFS1
612836,4:6273177:C>G,NM_006005.3:c.-6+1436C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,6.732,\N,\N,WFS1
612837,4:6273221:C>G,NM_006005.3:c.-6+1480C>G,\N,\N,1/7,Benign,\N,intron_variant,3.003,0.0598,1KG_AFR_AF,WFS1
612838,4:6273253:T>C,NM_006005.3:c.-6+1512T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,5.058,0.0015,1KG_AFR_AF,WFS1
612839,4:6273277:C>T,NM_006005.3:c.-6+1536C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,0.168,0.0015,1KG_AFR_AF,WFS1
612840,4:6273307:C>G,NM_006005.3:c.-6+1566C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.08,0.0008,1KG_AFR_AF,WFS1
612841,4:6273309:G>A,NM_006005.3:c.-6+1568G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.981,0.0029,1KG_AMR_AF,WFS1
612842,4:6273321:A>T,NM_006005.3:c.-6+1580A>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.717,0.001,1KG_EAS_AF,WFS1
612843,4:6273331:G>T,NM_006005.3:c.-6+1590G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,6.452,0.0043,1KG_AMR_AF,WFS1
612844,4:6273351:A>G,NM_006005.3:c.-6+1610A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,9.732,0.0029,1KG_AMR_AF,WFS1
612845,4:6273365:G>A,NM_006005.3:c.-6+1624G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.783,\N,\N,WFS1
612846,4:6273367:C>T,NM_006005.3:c.-6+1626C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.048,\N,\N,WFS1
612847,4:6273386:G>C,NM_006005.3:c.-6+1645G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.352,0.001,1KG_EAS_AF,WFS1
612848,4:6273418:G>A,NM_006005.3:c.-6+1677G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.623,\N,\N,WFS1
612849,4:6273432:G>A,NM_006005.3:c.-6+1691G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.28,0.0008,1KG_AFR_AF,WFS1
612850,4:6273458:C>T,NM_006005.3:c.-6+1717C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,0.385,\N,\N,WFS1
612851,4:6273483:C>G,NM_006005.3:c.-6+1742C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,7.132,\N,\N,WFS1
612852,4:6273483:C>T,NM_006005.3:c.-6+1742C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,8.286,\N,\N,WFS1
612853,4:6273488:C>T,NM_006005.3:c.-6+1747C>T,\N,\N,1/7,Benign,\N,intron_variant,3.489,0.0363,1KG_AFR_AF,WFS1
612854,4:6273489:G>A,NM_006005.3:c.-6+1748G>A,\N,\N,1/7,Benign,\N,intron_variant,0.555,0.0129,1KG_AFR_AF,WFS1
612855,4:6273499:G>A,NM_006005.3:c.-6+1758G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.615,0.001,1KG_EAS_AF,WFS1
612856,4:6273502:C>T,NM_006005.3:c.-6+1761C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.548,0.0023,1KG_AFR_AF,WFS1
612857,4:6273540:G>A,NM_006005.3:c.-6+1799G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.682,\N,\N,WFS1
612858,4:6273547:G>A,NM_006005.3:c.-6+1806G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,1.316,0.001,1KG_SAS_AF,WFS1
612859,4:6273565:G>C,NM_006005.3:c.-6+1824G>C,\N,\N,1/7,Benign,\N,intron_variant,0.482,0.0144,1KG_AFR_AF,WFS1
612860,4:6273568:C>T,NM_006005.3:c.-6+1827C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.994,0.003,1KG_AFR_AF,WFS1
612861,4:6273576:C>T,NM_006005.3:c.-6+1835C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.171,\N,\N,WFS1
612862,4:6273577:G>A,NM_006005.3:c.-6+1836G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,1.918,0.001,1KG_SAS_AF,WFS1
612863,4:6273588:G>A,NM_006005.3:c.-6+1847G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,1.042,0.001,1KG_SAS_AF,WFS1
612864,4:6273610:C>A,NM_006005.3:c.-6+1869C>A,\N,\N,1/7,Benign,\N,intron_variant,4.732,0.0719,1KG_AFR_AF,WFS1
612865,4:6273648:G>A,NM_006005.3:c.-6+1907G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.547,\N,\N,WFS1
612866,4:6273657:T>A,NM_006005.3:c.-6+1916T>A,\N,\N,1/7,Benign,\N,intron_variant,7.455,0.0184,1KG_SAS_AF,WFS1
612867,4:6273660:C>T,NM_006005.3:c.-6+1919C>T,\N,\N,1/7,Benign,\N,intron_variant,5.217,0.0719,1KG_AFR_AF,WFS1
612868,4:6273696:A>G,NM_006005.3:c.-6+1955A>G,\N,\N,1/7,Benign,\N,intron_variant,3.723,0.0061,1KG_SAS_AF,WFS1
612869,4:6273730:C>T,NM_006005.3:c.-6+1989C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.531,\N,\N,WFS1
612870,4:6273755:C>T,NM_006005.3:c.-6+2014C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.522,0.001,1KG_EAS_AF,WFS1
612871,4:6273775:C>G,NM_006005.3:c.-6+2034C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,13.63,0.0008,1KG_AFR_AF,WFS1
612872,4:6273802:T>G,NM_006005.3:c.-6+2061T>G,\N,\N,1/7,Benign,\N,intron_variant,6.354,0.9087,1KG_EAS_AF,WFS1
612873,4:6273812:G>C,NM_006005.3:c.-6+2071G>C,\N,\N,1/7,Benign,\N,intron_variant,2.563,0.0461,1KG_AMR_AF,WFS1
612874,4:6273843:G>A,NM_006005.3:c.-6+2102G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.391,\N,\N,WFS1
612875,4:6273864:G>A,NM_006005.3:c.-6+2123G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.679,0.001,1KG_EAS_AF,WFS1
612876,4:6273895:C>T,NM_006005.3:c.-6+2154C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5,0.0015,1KG_AFR_AF,WFS1
612877,4:6273901:A>G,NM_006005.3:c.-6+2160A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,1.217,0.001,1KG_EAS_AF,WFS1
612878,4:6273921:A>G,NM_006005.3:c.-6+2180A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,5.177,\N,\N,WFS1
612879,4:6273923:G>C,NM_006005.3:c.-6+2182G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.203,\N,\N,WFS1
612880,4:6273952:A>T,NM_006005.3:c.-6+2211A>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.664,0.001,1KG_SAS_AF,WFS1
612881,4:6274002:C>T,NM_006005.3:c.-6+2261C>T,\N,\N,1/7,Benign,\N,intron_variant,0.604,0.0174,1KG_AFR_AF,WFS1
612882,4:6274015:TCCAGGCCAGGCCTGGAGCAGGTGC>T,NM_006005.3:c.-6+2276_-6+2299del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
612883,4:6274023:A>G,NM_006005.3:c.-6+2282A>G,\N,\N,1/7,Benign,\N,intron_variant,5.671,0.1032,1KG_EAS_AF,WFS1
612884,4:6274045:G>GT,NM_006005.3:c.-6+2305dup,\N,\N,1/7,Benign,\N,intron_variant,8.94,0.007,1KG_EUR_AF,WFS1
612885,4:6274047:G>C,NM_006005.3:c.-6+2306G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,5.768,0.0008,1KG_AFR_AF,WFS1
612886,4:6274072:C>T,NM_006005.3:c.-6+2331C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.702,0.001,1KG_SAS_AF,WFS1
612887,4:6274073:G>A,NM_006005.3:c.-6+2332G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.458,0.003,1KG_AFR_AF,WFS1
612888,4:6274076:A>G,NM_006005.3:c.-6+2335A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.59,\N,\N,WFS1
612889,4:6274083:C>T,NM_006005.3:c.-6+2342C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.602,0.002,1KG_EAS_AF,WFS1
612890,4:6274106:A>G,NM_006005.3:c.-6+2365A>G,\N,\N,1/7,Benign,\N,intron_variant,1.05,0.0144,1KG_AFR_AF,WFS1
612891,4:6274115:G>C,NM_006005.3:c.-6+2374G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.997,\N,\N,WFS1
612892,4:6274133:C>T,NM_006005.3:c.-6+2392C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.549,\N,\N,WFS1
612893,4:6274154:T>A,NM_006005.3:c.-6+2413T>A,\N,\N,1/7,Benign,\N,intron_variant,18.73,0.0333,1KG_AFR_AF,WFS1
612894,4:6274167:C>T,NM_006005.3:c.-6+2426C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,17.37,0.001,1KG_SAS_AF,WFS1
612895,4:6274228:TGAG>T,NM_006005.3:c.-6+2491_-6+2493del,\N,\N,1/7,Unknown significance,\N,intron_variant,21.7,\N,\N,WFS1
612896,4:6274258:TCAGGC>T,NM_006005.3:c.-6+2526_-6+2530del,\N,\N,1/7,Unknown significance,\N,intron_variant,18.59,\N,\N,WFS1
612897,4:6274271:G>C,NM_006005.3:c.-6+2530G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,11.01,\N,\N,WFS1
612898,4:6274274:C>A,NM_006005.3:c.-6+2533C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,11.87,0.0008,1KG_AFR_AF,WFS1
612899,4:6274280:T>C,NM_006005.3:c.-6+2539T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,4.732,0.0014,1KG_AMR_AF,WFS1
612900,4:6274284:A>AG,NM_006005.3:c.-6+2546dup,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
612901,4:6274285:G>C,NM_006005.3:c.-6+2544G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,5.572,0.001,1KG_SAS_AF,WFS1
612902,4:6274299:T>C,NM_006005.3:c.-6+2558T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,5.099,\N,\N,WFS1
612903,4:6274305:T>G,NM_006005.3:c.-6+2564T>G,\N,\N,1/7,Benign,\N,intron_variant,3.846,0.0501,1KG_SAS_AF,WFS1
612904,4:6274318:C>G,NM_006005.3:c.-6+2577C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,5.896,0.0038,1KG_AFR_AF,WFS1
612905,4:6274355:A>C,NM_006005.3:c.-6+2614A>C,\N,\N,1/7,Unknown significance,\N,intron_variant,10.75,0.001,1KG_EAS_AF,WFS1
612906,4:6274357:T>G,NM_006005.3:c.-6+2616T>G,\N,\N,1/7,Benign,\N,intron_variant,12.13,0.0234,1KG_AFR_AF,WFS1
612907,4:6274360:C>G,NM_006005.3:c.-6+2619C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,11.73,0.0045,1KG_AFR_AF,WFS1
612908,4:6274377:C>G,NM_006005.3:c.-6+2636C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,1.866,\N,\N,WFS1
612909,4:6274397:A>T,NM_006005.3:c.-6+2656A>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.339,\N,\N,WFS1
612910,4:6274405:A>C,NM_006005.3:c.-6+2664A>C,\N,\N,1/7,Unknown significance,\N,intron_variant,3.439,\N,\N,WFS1
612911,4:6274427:G>A,NM_006005.3:c.-6+2686G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,1.966,0.0015,1KG_AFR_AF,WFS1
612912,4:6274429:G>A,NM_006005.3:c.-6+2688G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.334,0.001,1KG_EUR_AF,WFS1
612913,4:6274440:A>G,NM_006005.3:c.-6+2699A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.026,\N,\N,WFS1
612914,4:6274470:G>A,NM_006005.3:c.-6+2729G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.323,\N,\N,WFS1
612915,4:6274474:C>T,NM_006005.3:c.-6+2733C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.051,0.003,1KG_AFR_AF,WFS1
612916,4:6274475:G>A,NM_006005.3:c.-6+2734G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.999,0.001,1KG_SAS_AF,WFS1
612917,4:6274482:T>G,NM_006005.3:c.-6+2741T>G,\N,\N,1/7,Unknown significance,\N,intron_variant,3.269,\N,\N,WFS1
612918,4:6274484:C>T,NM_006005.3:c.-6+2743C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,2.348,\N,\N,WFS1
612919,4:6274485:G>A,NM_006005.3:c.-6+2744G>A,\N,\N,1/7,Benign,\N,intron_variant,1.588,0.0688,1KG_AFR_AF,WFS1
612920,4:6274486:T>C,NM_006005.3:c.-6+2745T>C,\N,\N,1/7,Benign,\N,intron_variant,3.142,0.006,1KG_EUR_AF,WFS1
612921,4:6274496:G>A,NM_006005.3:c.-6+2755G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.709,0.0008,1KG_AFR_AF,WFS1
612922,4:6274510:T>G,NM_006005.3:c.-6+2769T>G,\N,\N,1/7,Unknown significance,\N,intron_variant,10.45,\N,\N,WFS1
612923,4:6274517:A>T,NM_006005.3:c.-6+2776A>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.839,\N,\N,WFS1
612924,4:6274518:A>G,NM_006005.3:c.-6+2777A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,7.031,0.001,1KG_SAS_AF,WFS1
612925,4:6274528:G>A,NM_006005.3:c.-6+2787G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.807,0.001,1KG_EUR_AF,WFS1
612926,4:6274563:A>G,NM_006005.3:c.-6+2822A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.5,0.002,1KG_EAS_AF,WFS1
612927,4:6274574:C>G,NM_006005.3:c.-6+2833C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,1.616,\N,\N,WFS1
612928,4:6274607:C>T,NM_006005.3:c.-6+2866C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.628,\N,\N,WFS1
612929,4:6274624:G>C,NM_006005.3:c.-6+2883G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.702,0.001,1KG_SAS_AF,WFS1
612930,4:6274627:G>A,NM_006005.3:c.-6+2886G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.341,\N,\N,WFS1
612931,4:6274627:G>C,NM_006005.3:c.-6+2886G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.352,0.002,1KG_SAS_AF,WFS1
612932,4:6274629:A>G,NM_006005.3:c.-6+2888A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,0.776,0.003,1KG_AFR_AF,WFS1
612933,4:6274634:G>A,NM_006005.3:c.-6+2893G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.82,\N,\N,WFS1
612934,4:6274638:C>T,NM_006005.3:c.-6+2897C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,2.61,\N,\N,WFS1
612935,4:6274727:A>G,NM_006005.3:c.-6+2986A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,4.872,\N,\N,WFS1
612936,4:6274732:A>T,NM_006005.3:c.-6+2991A>T,\N,\N,1/7,Benign,\N,intron_variant,4.531,0.0582,1KG_AFR_AF,WFS1
612937,4:6274751:G>A,NM_006005.3:c.-6+3010G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.97,\N,\N,WFS1
612938,4:6274768:C>T,NM_006005.3:c.-6+3027C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,2.908,0.0023,1KG_AFR_AF,WFS1
612939,4:6274778:G>A,NM_006005.3:c.-6+3037G>A,\N,\N,1/7,Benign,\N,intron_variant,4.149,0.0153,1KG_SAS_AF,WFS1
612940,4:6274779:A>C,NM_006005.3:c.-6+3038A>C,\N,\N,1/7,Benign,\N,intron_variant,0.485,0.0153,1KG_SAS_AF,WFS1
612941,4:6274793:ACAT>A,NM_006005.3:c.-6+3057_-6+3059del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
612942,4:6274813:A>G,NM_006005.3:c.-6+3072A>G,\N,\N,1/7,Benign,\N,intron_variant,0.323,0.0688,1KG_AFR_AF,WFS1
612943,4:6274849:G>A,NM_006005.3:c.-6+3108G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.069,0.003,1KG_AFR_AF,WFS1
612944,4:6274852:GC>G,NM_006005.3:c.-6+3118del,\N,\N,1/7,Unknown significance,\N,intron_variant,2.454,0.0023,1KG_AFR_AF,WFS1
612945,4:6274859:C>A,NM_006005.3:c.-6+3118C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.575,0.001,1KG_EAS_AF,WFS1
612946,4:6274891:G>C,NM_006005.3:c.-6+3150G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,3.558,\N,\N,WFS1
612947,4:6274905:A>G,NM_006005.3:c.-6+3164A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,0.752,0.001,1KG_EUR_AF,WFS1
612948,4:6274937:C>T,NM_006005.3:c.-6+3196C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.34,0.001,1KG_EAS_AF,WFS1
612949,4:6274944:G>A,NM_006005.3:c.-6+3203G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.113,0.0045,1KG_AFR_AF,WFS1
612950,4:6274946:G>A,NM_006005.3:c.-6+3205G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.163,0.0023,1KG_AFR_AF,WFS1
612951,4:6274951:T>C,NM_006005.3:c.-6+3210T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.972,0.0014,1KG_AMR_AF,WFS1
612952,4:6274954:A>G,NM_006005.3:c.-6+3213A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,0.801,0.001,1KG_EAS_AF,WFS1
612953,4:6274958:T>C,NM_006005.3:c.-6+3217T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.735,0.0008,1KG_AFR_AF,WFS1
612954,4:6274965:A>C,NM_006005.3:c.-6+3224A>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.134,0.002,1KG_EAS_AF,WFS1
612955,4:6274978:T>A,NM_006005.3:c.-6+3237T>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.416,\N,\N,WFS1
612956,4:6275009:G>A,NM_006005.3:c.-6+3268G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.56,0.0014,1KG_AMR_AF,WFS1
612957,4:6275025:C>T,NM_006005.3:c.-6+3284C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,6.135,0.002,1KG_EAS_AF,WFS1
612958,4:6275026:G>A,NM_006005.3:c.-6+3285G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.838,0.0008,1KG_AFR_AF,WFS1
612959,4:6275026:G>C,NM_006005.3:c.-6+3285G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.622,\N,\N,WFS1
612960,4:6275038:T>C,NM_006005.3:c.-6+3297T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.996,\N,\N,WFS1
612961,4:6275053:G>A,NM_006005.3:c.-6+3312G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,8.435,\N,\N,WFS1
612962,4:6275077:G>T,NM_006005.3:c.-6+3336G>T,\N,\N,1/7,Benign,\N,intron_variant,0.85,0.0511,1KG_SAS_AF,WFS1
612963,4:6275138:T>C,NM_006005.3:c.-6+3397T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.061,\N,\N,WFS1
612964,4:6275154:A>G,NM_006005.3:c.-6+3413A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,6.176,\N,\N,WFS1
612965,4:6275156:C>A,NM_006005.3:c.-6+3415C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,7.551,\N,\N,WFS1
612966,4:6275157:G>A,NM_006005.3:c.-6+3416G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.788,0.0014,1KG_AMR_AF,WFS1
612967,4:6275162:G>T,NM_006005.3:c.-6+3421G>T,\N,\N,1/7,Benign,\N,intron_variant,0.724,0.0102,1KG_SAS_AF,WFS1
612968,4:6275164:T>C,NM_006005.3:c.-6+3423T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.263,\N,\N,WFS1
612969,4:6275171:C>G,NM_006005.3:c.-6+3430C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,3.049,0.0008,1KG_AFR_AF,WFS1
612970,4:6275177:G>T,NM_006005.3:c.-6+3436G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.206,0.0015,1KG_AFR_AF,WFS1
612971,4:6275185:T>C,NM_006005.3:c.-6+3444T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.976,\N,\N,WFS1
612972,4:6275269:C>T,NM_006005.3:c.-6+3528C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,6.169,0.001,1KG_EUR_AF,WFS1
612973,4:6275277:A>G,NM_006005.3:c.-6+3536A>G,\N,\N,1/7,Benign,\N,intron_variant,1.064,0.0287,1KG_AFR_AF,WFS1
612974,4:6275289:C>T,NM_006005.3:c.-6+3548C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,2.696,0.001,1KG_SAS_AF,WFS1
612975,4:6275294:G>GC,NM_006005.3:c.-6+3554dup,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
612976,4:6275294:GC>G,NM_006005.3:c.-6+3554del,\N,\N,1/7,Benign,\N,intron_variant,2.337,0.9038,1KG_EAS_AF,WFS1
612977,4:6275295:C>G,NM_006005.3:c.-6+3554C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,3.708,\N,\N,WFS1
612978,4:6275295:C>T,NM_006005.3:c.-6+3554C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.168,\N,\N,WFS1
612979,4:6275307:T>G,NM_006005.3:c.-6+3566T>G,\N,\N,1/7,Unknown significance,\N,intron_variant,3.074,0.0023,1KG_AFR_AF,WFS1
612980,4:6275319:T>C,NM_006005.3:c.-6+3578T>C,\N,\N,1/7,Benign,\N,intron_variant,1.065,0.0416,1KG_AFR_AF,WFS1
612981,4:6275324:G>A,NM_006005.3:c.-6+3583G>A,\N,\N,1/7,Benign,\N,intron_variant,1.21,0.0159,1KG_AFR_AF,WFS1
612982,4:6275341:G>GCCGGTCTT,NM_006005.3:c.-6+3604_-6+3611dup,\N,\N,1/7,Benign,\N,intron_variant,3.055,0.005,1KG_EAS_AF,WFS1
612983,4:6275343:C>CGGAAG,NM_006005.3:c.-6+3604_-6+3605insAAGGG,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
612984,4:6275351:C>T,NM_006005.3:c.-6+3610C>T,\N,\N,1/7,Benign,\N,intron_variant,3.645,0.025,1KG_AFR_AF,WFS1
612985,4:6275352:G>A,NM_006005.3:c.-6+3611G>A,\N,\N,1/7,Benign,\N,intron_variant,2.87,0.005,1KG_EUR_AF,WFS1
612986,4:6275352:G>C,NM_006005.3:c.-6+3611G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.783,\N,\N,WFS1
612987,4:6275375:C>T,NM_006005.3:c.-6+3634C>T,\N,\N,1/7,Benign,\N,intron_variant,8.019,0.0159,1KG_AFR_AF,WFS1
612988,4:6275404:A>C,NM_006005.3:c.-6+3663A>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.688,0.0023,1KG_AFR_AF,WFS1
612989,4:6275419:G>A,NM_006005.3:c.-6+3678G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,1.653,0.0014,1KG_AMR_AF,WFS1
612990,4:6275441:C>T,NM_006005.3:c.-6+3700C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.051,0.001,1KG_EAS_AF,WFS1
612991,4:6275448:C>T,NM_006005.3:c.-6+3707C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.128,\N,\N,WFS1
612992,4:6275475:C>A,NM_006005.3:c.-5-3703C>A,\N,\N,1/7,Benign,\N,intron_variant,7.097,0.0099,1KG_EUR_AF,WFS1
612993,4:6275488:C>T,NM_006005.3:c.-5-3690C>T,\N,\N,1/7,Benign,\N,intron_variant,3.03,0.0136,1KG_AFR_AF,WFS1
612994,4:6275522:A>T,NM_006005.3:c.-5-3656A>T,\N,\N,1/7,Unknown significance,\N,intron_variant,10.72,0.0008,1KG_AFR_AF,WFS1
612995,4:6275556:C>T,NM_006005.3:c.-5-3622C>T,\N,\N,1/7,Benign,\N,intron_variant,5.092,0.0416,1KG_AFR_AF,WFS1
612996,4:6275558:C>T,NM_006005.3:c.-5-3620C>T,\N,\N,1/7,Benign,\N,intron_variant,6.798,0.0883,1KG_EAS_AF,WFS1
612997,4:6275568:T>A,NM_006005.3:c.-5-3610T>A,\N,\N,1/7,Unknown significance,\N,intron_variant,9.527,0.0008,1KG_AFR_AF,WFS1
612998,4:6275598:C>A,NM_006005.3:c.-5-3580C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.638,\N,\N,WFS1
612999,4:6275602:C>G,NM_006005.3:c.-5-3576C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,8.799,0.0038,1KG_AFR_AF,WFS1
613000,4:6275624:A>T,NM_006005.3:c.-5-3554A>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.605,\N,\N,WFS1
613001,4:6275627:G>GT,NM_006005.3:c.-5-3542dup,\N,\N,1/7,Unknown significance,\N,intron_variant,1.695,\N,\N,WFS1
613002,4:6275654:C>T,NM_006005.3:c.-5-3524C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.337,0.002,1KG_EAS_AF,WFS1
613003,4:6275678:C>T,NM_006005.3:c.-5-3500C>T,\N,\N,1/7,Benign,\N,intron_variant,14.32,0.0086,1KG_AMR_AF,WFS1
613004,4:6275684:T>C,NM_006005.3:c.-5-3494T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,14.05,\N,\N,WFS1
613005,4:6275716:C>G,NM_006005.3:c.-5-3462C>G,\N,\N,1/7,Benign,\N,intron_variant,3.326,0.0098,1KG_AFR_AF,WFS1
613006,4:6275735:G>A,NM_006005.3:c.-5-3443G>A,\N,\N,1/7,Benign,\N,intron_variant,3.468,0.1849,1KG_EUR_AF,WFS1
613007,4:6275761:TTTC>T,NM_006005.3:c.-5-3414_-5-3412del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613008,4:6275763:T>C,NM_006005.3:c.-5-3415T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,4.556,0.004,1KG_EAS_AF,WFS1
613009,4:6275770:CTTTTTCT>C,NM_006005.3:c.-5-3395_-5-3389del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613010,4:6275777:T>C,NM_006005.3:c.-5-3401T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.956,\N,\N,WFS1
613011,4:6275781:TTC>T,NM_006005.3:c.-5-3395_-5-3394del,\N,\N,1/7,Unknown significance,\N,intron_variant,3.247,\N,\N,WFS1
613012,4:6275782:T>TC,NM_006005.3:c.-5-3395dup,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613013,4:6275782:T>TTC,NM_006005.3:c.-5-3396_-5-3395insTC,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613014,4:6275782:TC>T,NM_006005.3:c.-5-3395del,\N,\N,1/7,Benign,\N,intron_variant,3.418,0.9077,1KG_EAS_AF,WFS1
613015,4:6275783:C>T,NM_006005.3:c.-5-3395C>T,\N,\N,1/7,Benign,\N,intron_variant,2.836,0.5556,1KG_EAS_AF,WFS1
613016,4:6275805:G>A,NM_006005.3:c.-5-3373G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.884,\N,\N,WFS1
613017,4:6275855:G>T,NM_006005.3:c.-5-3323G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,2.103,0.0008,1KG_AFR_AF,WFS1
613018,4:6275874:C>G,NM_006005.3:c.-5-3304C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.634,\N,\N,WFS1
613019,4:6275896:C>A,NM_006005.3:c.-5-3282C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.523,\N,\N,WFS1
613020,4:6275918:C>T,NM_006005.3:c.-5-3260C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.56,\N,\N,WFS1
613021,4:6275923:G>A,NM_006005.3:c.-5-3255G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.078,\N,\N,WFS1
613022,4:6275931:G>A,NM_006005.3:c.-5-3247G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.11,0.003,1KG_EAS_AF,WFS1
613023,4:6275948:GTATTTTTAA>G,NM_006005.3:c.-5-3227_-5-3219del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613024,4:6275957:A>G,NM_006005.3:c.-5-3221A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,4.453,\N,\N,WFS1
613025,4:6275964:C>T,NM_006005.3:c.-5-3214C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,0.312,0.001,1KG_SAS_AF,WFS1
613026,4:6275975:T>C,NM_006005.3:c.-5-3203T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.564,0.002,1KG_EUR_AF,WFS1
613027,4:6275988:A>G,NM_006005.3:c.-5-3190A>G,\N,\N,1/7,Benign,\N,intron_variant,2.794,0.0058,1KG_AMR_AF,WFS1
613028,4:6275989:T>C,NM_006005.3:c.-5-3189T>C,\N,\N,1/7,Benign,\N,intron_variant,3.079,0.0144,1KG_AFR_AF,WFS1
613029,4:6275995:T>C,NM_006005.3:c.-5-3183T>C,\N,\N,1/7,Benign,\N,intron_variant,2.204,0.0091,1KG_AFR_AF,WFS1
613030,4:6276016:T>C,NM_006005.3:c.-5-3162T>C,\N,\N,1/7,Benign,\N,intron_variant,0.432,0.0144,1KG_AFR_AF,WFS1
613031,4:6276020:C>T,NM_006005.3:c.-5-3158C>T,\N,\N,1/7,Benign,\N,intron_variant,0.161,0.0136,1KG_AFR_AF,WFS1
613032,4:6276035:A>G,NM_006005.3:c.-5-3143A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,5.073,\N,\N,WFS1
613033,4:6276039:G>A,NM_006005.3:c.-5-3139G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.767,0.0029,1KG_AMR_AF,WFS1
613034,4:6276062:C>T,NM_006005.3:c.-5-3116C>T,\N,\N,1/7,Benign,\N,intron_variant,5.051,0.0082,1KG_SAS_AF,WFS1
613035,4:6276065:C>T,NM_006005.3:c.-5-3113C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.3,0.001,1KG_EUR_AF,WFS1
613036,4:6276066:G>A,NM_006005.3:c.-5-3112G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.281,\N,\N,WFS1
613037,4:6276073:C>A,NM_006005.3:c.-5-3105C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.109,0.0014,1KG_AMR_AF,WFS1
613038,4:6276081:T>G,NM_006005.3:c.-5-3097T>G,\N,\N,1/7,Benign,\N,intron_variant,0.324,0.0091,1KG_AFR_AF,WFS1
613039,4:6276109:T>C,NM_006005.3:c.-5-3069T>C,\N,\N,1/7,Benign,\N,intron_variant,6.13,0.005,1KG_EUR_AF,WFS1
613040,4:6276126:G>A,NM_006005.3:c.-5-3052G>A,\N,\N,1/7,Benign,\N,intron_variant,0.014,0.501,1KG_EAS_AF,WFS1
613041,4:6276176:T>C,NM_006005.3:c.-5-3002T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,2.546,0.001,1KG_SAS_AF,WFS1
613042,4:6276194:G>C,NM_006005.3:c.-5-2984G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.674,0.002,1KG_SAS_AF,WFS1
613043,4:6276196:G>A,NM_006005.3:c.-5-2982G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.87,\N,\N,WFS1
613044,4:6276197:G>A,NM_006005.3:c.-5-2981G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.133,\N,\N,WFS1
613045,4:6276236:C>G,NM_006005.3:c.-5-2942C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,3.102,0.0008,1KG_AFR_AF,WFS1
613046,4:6276281:G>A,NM_006005.3:c.-5-2897G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.837,\N,\N,WFS1
613047,4:6276291:T>C,NM_006005.3:c.-5-2887T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.171,0.0008,1KG_AFR_AF,WFS1
613048,4:6276292:C>T,NM_006005.3:c.-5-2886C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,0.485,0.0014,1KG_AMR_AF,WFS1
613049,4:6276293:G>A,NM_006005.3:c.-5-2885G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.084,0.001,1KG_SAS_AF,WFS1
613050,4:6276318:G>A,NM_006005.3:c.-5-2860G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.353,0.0015,1KG_AFR_AF,WFS1
613051,4:6276340:C>T,NM_006005.3:c.-5-2838C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.394,\N,\N,WFS1
613052,4:6276341:G>A,NM_006005.3:c.-5-2837G>A,\N,\N,1/7,Benign,\N,intron_variant,0.233,0.0212,1KG_AFR_AF,WFS1
613053,4:6276368:CA>C,NM_006005.3:c.-5-2807del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613054,4:6276378:A>G,NM_006005.3:c.-5-2800A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,3.518,\N,\N,WFS1
613055,4:6276406:CT>C,NM_006005.3:c.-5-2770del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613056,4:6276446:C>T,NM_006005.3:c.-5-2732C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.031,\N,\N,WFS1
613057,4:6276459:C>T,NM_006005.3:c.-5-2719C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,2.081,0.001,1KG_SAS_AF,WFS1
613058,4:6276533:G>A,NM_006005.3:c.-5-2645G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.122,\N,\N,WFS1
613059,4:6276538:C>G,NM_006005.3:c.-5-2640C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,0.037,\N,\N,WFS1
613060,4:6276539:G>A,NM_006005.3:c.-5-2639G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.207,\N,\N,WFS1
613061,4:6276554:G>GTGGCA,NM_006005.3:c.-5-2619_-5-2615dup,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613062,4:6276554:GTGGCA>G,NM_006005.3:c.-5-2619_-5-2615del,\N,\N,1/7,Benign,\N,intron_variant,3.714,0.5166,1KG_AFR_AF,WFS1
613063,4:6276559:A>AG,NM_006005.3:c.-5-2619_-5-2618insG,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613064,4:6276559:A>ATGGCG,NM_006005.3:c.-5-2618_-5-2614dup,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613065,4:6276559:ATGGCG>A,NM_006005.3:c.-5-2618_-5-2614del,\N,\N,1/7,Unknown significance,\N,intron_variant,3.464,\N,\N,WFS1
613066,4:6276560:T>G,NM_006005.3:c.-5-2618T>G,\N,\N,1/7,Unknown significance,\N,intron_variant,4.384,\N,\N,WFS1
613067,4:6276564:G>A,NM_006005.3:c.-5-2614G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.221,\N,\N,WFS1
613068,4:6276581:G>A,NM_006005.3:c.-5-2597G>A,\N,\N,1/7,Benign,\N,intron_variant,0.133,0.9067,1KG_EAS_AF,WFS1
613069,4:6276586:T>C,NM_006005.3:c.-5-2592T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,2.168,0.001,1KG_EUR_AF,WFS1
613070,4:6276609:C>T,NM_006005.3:c.-5-2569C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.606,\N,\N,WFS1
613071,4:6276617:T>C,NM_006005.3:c.-5-2561T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.194,0.0008,1KG_AFR_AF,WFS1
613072,4:6276630:G>C,NM_006005.3:c.-5-2548G>C,\N,\N,1/7,Benign,\N,intron_variant,0.968,0.2286,1KG_EUR_AF,WFS1
613073,4:6276670:T>C,NM_006005.3:c.-5-2508T>C,\N,\N,1/7,Benign,\N,intron_variant,4.215,0.0068,1KG_AFR_AF,WFS1
613074,4:6276681:C>T,NM_006005.3:c.-5-2497C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.095,0.0008,1KG_AFR_AF,WFS1
613075,4:6276688:C>T,NM_006005.3:c.-5-2490C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.056,\N,\N,WFS1
613076,4:6276713:A>C,NM_006005.3:c.-5-2465A>C,\N,\N,1/7,Benign,\N,intron_variant,1.961,0.0069,1KG_EAS_AF,WFS1
613077,4:6276720:G>A,NM_006005.3:c.-5-2458G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.157,\N,\N,WFS1
613078,4:6276732:G>A,NM_006005.3:c.-5-2446G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.118,0.0008,1KG_AFR_AF,WFS1
613079,4:6276752:A>G,NM_006005.3:c.-5-2426A>G,\N,\N,1/7,Benign,\N,intron_variant,1.754,0.0582,1KG_AFR_AF,WFS1
613080,4:6276792:T>C,NM_006005.3:c.-5-2386T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.905,\N,\N,WFS1
613081,4:6276805:C>T,NM_006005.3:c.-5-2373C>T,\N,\N,1/7,Benign,\N,intron_variant,0.541,0.1849,1KG_EUR_AF,WFS1
613082,4:6276811:T>C,NM_006005.3:c.-5-2367T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,4.877,\N,\N,WFS1
613083,4:6276817:C>G,NM_006005.3:c.-5-2361C>G,\N,\N,1/7,Benign,\N,intron_variant,4.546,0.0348,1KG_AFR_AF,WFS1
613084,4:6276835:C>T,NM_006005.3:c.-5-2343C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.598,\N,\N,WFS1
613085,4:6276836:G>A,NM_006005.3:c.-5-2342G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.656,0.001,1KG_EAS_AF,WFS1
613086,4:6276852:A>G,NM_006005.3:c.-5-2326A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.05,0.001,1KG_EUR_AF,WFS1
613087,4:6276876:G>A,NM_006005.3:c.-5-2302G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.376,0.001,1KG_SAS_AF,WFS1
613088,4:6276887:T>A,NM_006005.3:c.-5-2291T>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.73,0.0008,1KG_AFR_AF,WFS1
613089,4:6276888:G>T,NM_006005.3:c.-5-2290G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,2.665,0.0008,1KG_AFR_AF,WFS1
613090,4:6276905:G>A,NM_006005.3:c.-5-2273G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.872,\N,\N,WFS1
613091,4:6276920:G>A,NM_006005.3:c.-5-2258G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.474,0.0029,1KG_AMR_AF,WFS1
613092,4:6276973:T>C,NM_006005.3:c.-5-2205T>C,\N,\N,1/7,Benign,\N,intron_variant,2.195,0.0711,1KG_AFR_AF,WFS1
613093,4:6276984:G>A,NM_006005.3:c.-5-2194G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.038,\N,\N,WFS1
613094,4:6276990:A>G,NM_006005.3:c.-5-2188A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,1.105,0.001,1KG_SAS_AF,WFS1
613095,4:6277003:C>G,NM_006005.3:c.-5-2175C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.927,\N,\N,WFS1
613096,4:6277041:G>C,NM_006005.3:c.-5-2137G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,6.398,\N,\N,WFS1
613097,4:6277049:G>A,NM_006005.3:c.-5-2129G>A,\N,\N,1/7,Benign,\N,intron_variant,0.192,0.9067,1KG_EAS_AF,WFS1
613098,4:6277065:G>A,NM_006005.3:c.-5-2113G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.276,0.0015,1KG_AFR_AF,WFS1
613099,4:6277081:A>C,NM_006005.3:c.-5-2097A>C,\N,\N,1/7,Unknown significance,\N,intron_variant,3.786,0.001,1KG_SAS_AF,WFS1
613100,4:6277099:G>C,NM_006005.3:c.-5-2079G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.002,0.0008,1KG_AFR_AF,WFS1
613101,4:6277107:C>A,NM_006005.3:c.-5-2071C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.65,0.0008,1KG_AFR_AF,WFS1
613102,4:6277111:A>G,NM_006005.3:c.-5-2067A>G,\N,\N,1/7,Benign,\N,intron_variant,1.412,0.0091,1KG_AFR_AF,WFS1
613103,4:6277132:A>G,NM_006005.3:c.-5-2046A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.63,\N,\N,WFS1
613104,4:6277153:C>T,NM_006005.3:c.-5-2025C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,2.789,0.001,1KG_EUR_AF,WFS1
613105,4:6277154:G>A,NM_006005.3:c.-5-2024G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.555,\N,\N,WFS1
613106,4:6277166:G>A,NM_006005.3:c.-5-2012G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.896,\N,\N,WFS1
613107,4:6277176:G>C,NM_006005.3:c.-5-2002G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.292,0.0015,1KG_AFR_AF,WFS1
613108,4:6277177:T>C,NM_006005.3:c.-5-2001T>C,\N,\N,1/7,Benign,\N,intron_variant,1.26,0.0182,1KG_AFR_AF,WFS1
613109,4:6277199:G>T,NM_006005.3:c.-5-1979G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.827,\N,\N,WFS1
613110,4:6277200:C>G,NM_006005.3:c.-5-1978C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,4.062,\N,\N,WFS1
613111,4:6277216:A>C,NM_006005.3:c.-5-1962A>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.41,0.004,1KG_EAS_AF,WFS1
613112,4:6277253:T>C,NM_006005.3:c.-5-1925T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,2.226,0.0023,1KG_AFR_AF,WFS1
613113,4:6277272:C>G,NM_006005.3:c.-5-1906C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,0.242,0.0015,1KG_AFR_AF,WFS1
613114,4:6277274:G>A,NM_006005.3:c.-5-1904G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.102,0.0008,1KG_AFR_AF,WFS1
613115,4:6277276:G>C,NM_006005.3:c.-5-1902G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.468,0.0015,1KG_AFR_AF,WFS1
613116,4:6277281:C>T,NM_006005.3:c.-5-1897C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,0.881,\N,\N,WFS1
613117,4:6277326:TGGGG>T,NM_006005.3:c.-5-1843_-5-1840del,\N,\N,1/7,Benign,\N,intron_variant,0.66,1,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,WFS1
613118,4:6277326:TGGGGG>T,NM_006005.3:c.-5-1844_-5-1840del,\N,\N,1/7,Unknown significance,\N,intron_variant,0.54,\N,\N,WFS1
613119,4:6277330:G>T,NM_006005.3:c.-5-1848G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,0.645,\N,\N,WFS1
613120,4:6277335:GGGGT>G,NM_006005.3:c.-5-1841_-5-1838del,\N,\N,1/7,Unknown significance,\N,intron_variant,1.04,\N,\N,WFS1
613121,4:6277338:G>GC,NM_006005.3:c.-5-1840_-5-1839insC,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613122,4:6277338:GT>G,NM_006005.3:c.-5-1839del,\N,\N,1/7,Unknown significance,\N,intron_variant,1.155,\N,\N,WFS1
613123,4:6277339:T>G,NM_006005.3:c.-5-1839T>G,\N,\N,1/7,Unknown significance,\N,intron_variant,3.732,\N,\N,WFS1
613124,4:6277368:G>C,NM_006005.3:c.-5-1810G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.409,\N,\N,WFS1
613125,4:6277412:G>A,NM_006005.3:c.-5-1766G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.628,0.002,1KG_EAS_AF,WFS1
613126,4:6277483:G>A,NM_006005.3:c.-5-1695G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.947,\N,\N,WFS1
613127,4:6277492:AT>A,NM_006005.3:c.-5-1684del,\N,\N,1/7,Benign,\N,intron_variant,2.937,0.0855,1KG_AFR_AF,WFS1
613128,4:6277492:ATTG>A,NM_006005.3:c.-5-1681_-5-1679del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613129,4:6277545:C>G,NM_006005.3:c.-5-1633C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.063,\N,\N,WFS1
613130,4:6277547:C>G,NM_006005.3:c.-5-1631C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,0.541,\N,\N,WFS1
613131,4:6277557:C>A,NM_006005.3:c.-5-1621C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.539,0.003,1KG_EAS_AF,WFS1
613132,4:6277557:C>T,NM_006005.3:c.-5-1621C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.38,0.0014,1KG_AMR_AF,WFS1
613133,4:6277574:G>A,NM_006005.3:c.-5-1604G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.662,0.001,1KG_SAS_AF,WFS1
613134,4:6277597:G>A,NM_006005.3:c.-5-1581G>A,\N,\N,1/7,Benign,\N,intron_variant,0.858,0.9067,1KG_EAS_AF,WFS1
613135,4:6277599:TGG>T,NM_006005.3:c.-5-1577_-5-1576del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613136,4:6277603:T>A,NM_006005.3:c.-5-1575T>A,\N,\N,1/7,Benign,\N,intron_variant,3.535,0.0582,1KG_AFR_AF,WFS1
613137,4:6277616:C>A,NM_006005.3:c.-5-1562C>A,\N,\N,1/7,Benign,\N,intron_variant,5.436,0.0182,1KG_AFR_AF,WFS1
613138,4:6277658:G>A,NM_006005.3:c.-5-1520G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.813,\N,\N,WFS1
613139,4:6277676:G>A,NM_006005.3:c.-5-1502G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,1.947,0.001,1KG_SAS_AF,WFS1
613140,4:6277680:C>G,NM_006005.3:c.-5-1498C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,1.708,\N,\N,WFS1
613141,4:6277695:G>C,NM_006005.3:c.-5-1483G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.459,\N,\N,WFS1
613142,4:6277715:G>C,NM_006005.3:c.-5-1463G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.5,0.001,1KG_SAS_AF,WFS1
613143,4:6277725:G>A,NM_006005.3:c.-5-1453G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.596,\N,\N,WFS1
613144,4:6277731:G>A,NM_006005.3:c.-5-1447G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,8.011,0.0008,1KG_AFR_AF,WFS1
613145,4:6277737:A>C,NM_006005.3:c.-5-1441A>C,\N,\N,1/7,Unknown significance,\N,intron_variant,3.941,0.001,1KG_EAS_AF,WFS1
613146,4:6277745:T>C,NM_006005.3:c.-5-1433T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,1.382,0.001,1KG_SAS_AF,WFS1
613147,4:6277750:A>T,NM_006005.3:c.-5-1428A>T,\N,\N,1/7,Unknown significance,\N,intron_variant,0.549,\N,\N,WFS1
613148,4:6277755:G>A,NM_006005.3:c.-5-1423G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.211,0.002,1KG_EUR_AF,WFS1
613149,4:6277769:G>T,NM_006005.3:c.-5-1409G>T,\N,\N,1/7,Benign,\N,intron_variant,0.827,0.0136,1KG_AFR_AF,WFS1
613150,4:6277797:ACT>A,NM_006005.3:c.-5-1376_-5-1375del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613151,4:6277883:A>G,NM_006005.3:c.-5-1295A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,8.284,\N,\N,WFS1
613152,4:6277921:T>C,NM_006005.3:c.-5-1257T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,2.856,0.0015,1KG_AFR_AF,WFS1
613153,4:6277924:A>G,NM_006005.3:c.-5-1254A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.344,0.0031,1KG_SAS_AF,WFS1
613154,4:6277937:G>A,NM_006005.3:c.-5-1241G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,6.523,\N,\N,WFS1
613155,4:6277952:C>G,NM_006005.3:c.-5-1226C>G,\N,\N,1/7,Benign,\N,intron_variant,3.963,0.0545,1KG_AFR_AF,WFS1
613156,4:6277957:G>A,NM_006005.3:c.-5-1221G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.63,\N,\N,WFS1
613157,4:6277966:C>A,NM_006005.3:c.-5-1212C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.52,\N,\N,WFS1
613158,4:6277967:C>G,NM_006005.3:c.-5-1211C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,3.011,0.0014,1KG_AMR_AF,WFS1
613159,4:6277975:A>G,NM_006005.3:c.-5-1203A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,4.075,\N,\N,WFS1
613160,4:6277978:C>T,NM_006005.3:c.-5-1200C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,0.851,0.0008,1KG_AFR_AF,WFS1
613161,4:6277984:C>T,NM_006005.3:c.-5-1194C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.493,\N,\N,WFS1
613162,4:6277985:G>A,NM_006005.3:c.-5-1193G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.478,\N,\N,WFS1
613163,4:6277992:G>A,NM_006005.3:c.-5-1186G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.136,\N,\N,WFS1
613164,4:6277995:A>G,NM_006005.3:c.-5-1183A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,0.484,\N,\N,WFS1
613165,4:6278029:G>A,NM_006005.3:c.-5-1149G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.271,0.004,1KG_EAS_AF,WFS1
613166,4:6278029:G>C,NM_006005.3:c.-5-1149G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.055,0.002,1KG_EUR_AF,WFS1
613167,4:6278030:G>A,NM_006005.3:c.-5-1148G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.253,\N,\N,WFS1
613168,4:6278051:G>C,NM_006005.3:c.-5-1127G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.783,0.003,1KG_AFR_AF,WFS1
613169,4:6278052:ATGG>A,NM_006005.3:c.-5-1120_-5-1118del,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613170,4:6278062:T>C,NM_006005.3:c.-5-1116T>C,\N,\N,1/7,Benign,\N,intron_variant,6.288,0.0069,1KG_EAS_AF,WFS1
613171,4:6278067:C>T,NM_006005.3:c.-5-1111C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,10.35,0.0023,1KG_AFR_AF,WFS1
613172,4:6278097:G>A,NM_006005.3:c.-5-1081G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.245,0.001,1KG_EAS_AF,WFS1
613173,4:6278119:C>T,NM_006005.3:c.-5-1059C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,6.109,0.0014,1KG_AMR_AF,WFS1
613174,4:6278124:G>C,NM_006005.3:c.-5-1054G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.151,0.003,1KG_AFR_AF,WFS1
613175,4:6278132:C>T,NM_006005.3:c.-5-1046C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,6.538,0.0015,1KG_AFR_AF,WFS1
613176,4:6278139:C>T,NM_006005.3:c.-5-1039C>T,\N,\N,1/7,Benign,\N,intron_variant,1.907,0.0477,1KG_AFR_AF,WFS1
613177,4:6278140:G>A,NM_006005.3:c.-5-1038G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,1.047,0.0029,1KG_AMR_AF,WFS1
613178,4:6278159:G>C,NM_006005.3:c.-5-1019G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.703,0.001,1KG_SAS_AF,WFS1
613179,4:6278179:C>T,NM_006005.3:c.-5-999C>T,\N,\N,1/7,Benign,\N,intron_variant,5.368,0.0083,1KG_AFR_AF,WFS1
613180,4:6278209:C>T,NM_006005.3:c.-5-969C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,0.461,\N,\N,WFS1
613181,4:6278213:G>C,NM_006005.3:c.-5-965G>C,\N,\N,1/7,Unknown significance,\N,intron_variant,2.441,\N,\N,WFS1
613182,4:6278219:G>A,NM_006005.3:c.-5-959G>A,\N,\N,1/7,Benign,\N,intron_variant,3.286,0.9107,1KG_EAS_AF,WFS1
613183,4:6278229:C>T,NM_006005.3:c.-5-949C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.812,0.003,1KG_EUR_AF,WFS1
613184,4:6278237:C>T,NM_006005.3:c.-5-941C>T,\N,\N,1/7,Benign,\N,intron_variant,6.361,0.005,1KG_EAS_AF,WFS1
613185,4:6278239:C>T,NM_006005.3:c.-5-939C>T,\N,\N,1/7,Benign,\N,intron_variant,2.521,0.0454,1KG_AFR_AF,WFS1
613186,4:6278243:C>T,NM_006005.3:c.-5-935C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.739,0.001,1KG_SAS_AF,WFS1
613187,4:6278251:C>G,NM_006005.3:c.-5-927C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.39,\N,\N,WFS1
613188,4:6278251:C>T,NM_006005.3:c.-5-927C>T,\N,\N,1/7,Benign,\N,intron_variant,4.737,0.9067,1KG_EAS_AF,WFS1
613189,4:6278260:G>T,NM_006005.3:c.-5-918G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.361,\N,\N,WFS1
613190,4:6278293:T>G,NM_006005.3:c.-5-885T>G,\N,\N,1/7,Benign,\N,intron_variant,2.96,0.0106,1KG_AFR_AF,WFS1
613191,4:6278306:C>T,NM_006005.3:c.-5-872C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.601,0.001,1KG_SAS_AF,WFS1
613192,4:6278315:C>T,NM_006005.3:c.-5-863C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,4.785,0.0014,1KG_AMR_AF,WFS1
613193,4:6278325:C>T,NM_006005.3:c.-5-853C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.12,0.0014,1KG_AMR_AF,WFS1
613194,4:6278354:C>G,NM_006005.3:c.-5-824C>G,\N,\N,1/7,Benign,\N,intron_variant,3.449,0.0194,1KG_SAS_AF,WFS1
613195,4:6278355:C>A,NM_006005.3:c.-5-823C>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.883,0.0008,1KG_AFR_AF,WFS1
613196,4:6278367:C>T,NM_006005.3:c.-5-811C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.993,\N,\N,WFS1
613197,4:6278394:T>G,NM_006005.3:c.-5-784T>G,\N,\N,1/7,Unknown significance,\N,intron_variant,1.678,\N,\N,WFS1
613198,4:6278398:C>G,NM_006005.3:c.-5-780C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,1.105,\N,\N,WFS1
613199,4:6278404:C>T,NM_006005.3:c.-5-774C>T,\N,\N,1/7,Benign,\N,intron_variant,3.949,0.0091,1KG_AFR_AF,WFS1
613200,4:6278405:A>G,NM_006005.3:c.-5-773A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,0.602,\N,\N,WFS1
613201,4:6278406:GCG>ACA,NM_006005.3:c.-5-772_-5-770delinsACA,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613202,4:6278408:G>A,NM_006005.3:c.-5-770G>A,\N,\N,1/7,Benign,\N,intron_variant,3.361,0.0386,1KG_AFR_AF,WFS1
613203,4:6278430:G>A,NM_006005.3:c.-5-748G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,3.242,0,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,WFS1
613204,4:6278439:T>G,NM_006005.3:c.-5-739T>G,\N,\N,1/7,Benign,\N,intron_variant,3.475,0.0197,1KG_AFR_AF,WFS1
613205,4:6278466:C>G,NM_006005.3:c.-5-712C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,4.59,0.0008,1KG_AFR_AF,WFS1
613206,4:6278498:G>A,NM_006005.3:c.-5-680G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.519,0.003,1KG_AFR_AF,WFS1
613207,4:6278501:G>A,NM_006005.3:c.-5-677G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.538,0.001,1KG_EUR_AF,WFS1
613208,4:6278566:G>A,NM_006005.3:c.-5-612G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.091,0.0015,1KG_AFR_AF,WFS1
613209,4:6278574:C>G,NM_006005.3:c.-5-604C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,6.312,\N,\N,WFS1
613210,4:6278578:C>G,NM_006005.3:c.-5-600C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,3.27,\N,\N,WFS1
613211,4:6278603:C>G,NM_006005.3:c.-5-575C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,1.593,0.001,1KG_EUR_AF,WFS1
613212,4:6278625:C>T,NM_006005.3:c.-5-553C>T,\N,\N,1/7,Benign,\N,intron_variant,3.431,0.0749,1KG_AFR_AF,WFS1
613213,4:6278626:G>A,NM_006005.3:c.-5-552G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.204,0.001,1KG_EAS_AF,WFS1
613214,4:6278632:G>A,NM_006005.3:c.-5-546G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.237,0.001,1KG_EAS_AF,WFS1
613215,4:6278646:C>T,NM_006005.3:c.-5-532C>T,\N,\N,1/7,Benign,\N,intron_variant,1.927,0.0437,1KG_EUR_AF,WFS1
613216,4:6278646:CA>TG,NM_006005.3:c.-5-532_-5-531inv,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613217,4:6278647:A>G,NM_006005.3:c.-5-531A>G,\N,\N,1/7,Benign,\N,intron_variant,2.596,0.9107,1KG_EAS_AF,WFS1
613218,4:6278653:C>T,NM_006005.3:c.-5-525C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.836,\N,\N,WFS1
613219,4:6278660:T>TA,NM_006005.3:c.-5-517dup,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613220,4:6278719:C>T,NM_006005.3:c.-5-459C>T,\N,\N,1/7,Benign,\N,intron_variant,4.278,0.005,1KG_EUR_AF,WFS1
613221,4:6278734:C>G,NM_006005.3:c.-5-444C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,2.42,\N,\N,WFS1
613222,4:6278743:G>T,NM_006005.3:c.-5-435G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.214,0.0008,1KG_AFR_AF,WFS1
613223,4:6278758:G>A,NM_006005.3:c.-5-420G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.559,\N,\N,WFS1
613224,4:6278795:G>T,NM_006005.3:c.-5-383G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,6.414,\N,\N,WFS1
613225,4:6278809:C>T,NM_006005.3:c.-5-369C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,8.06,\N,\N,WFS1
613226,4:6278835:G>A,NM_006005.3:c.-5-343G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,1.233,0.0008,1KG_AFR_AF,WFS1
613227,4:6278850:A>G,NM_006005.3:c.-5-328A>G,\N,\N,1/7,Benign,\N,intron_variant,1.608,0.0089,1KG_EUR_AF,WFS1
613228,4:6278870:G>A,NM_006005.3:c.-5-308G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,1.2,\N,\N,WFS1
613229,4:6278883:C>T,NM_006005.3:c.-5-295C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.159,\N,\N,WFS1
613230,4:6278916:G>A,NM_006005.3:c.-5-262G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,4.916,0.001,1KG_SAS_AF,WFS1
613231,4:6278918:C>CT,NM_006005.3:c.-5-259dup,\N,\N,1/7,Benign,\N,intron_variant,5.604,0.0356,1KG_AFR_AF,WFS1
613232,4:6278923:G>C,NM_006005.3:c.-5-255G>C,\N,\N,1/7,Benign,\N,intron_variant,2.905,0.0673,1KG_AFR_AF,WFS1
613233,4:6278926:C>G,NM_006005.3:c.-5-252C>G,\N,\N,1/7,Unknown significance,\N,intron_variant,6.774,0.001,1KG_SAS_AF,WFS1
613234,4:6278948:T>C,NM_006005.3:c.-5-230T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.586,\N,\N,WFS1
613235,4:6278961:G>A,NM_006005.3:c.-5-217G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.995,\N,\N,WFS1
613236,4:6278969:T>C,NM_006005.3:c.-5-209T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,2.809,\N,\N,WFS1
613237,4:6278973:G>C,NM_006005.3:c.-5-205G>C,\N,\N,1/7,Benign,\N,intron_variant,1.402,0.0688,1KG_AFR_AF,WFS1
613238,4:6278977:C>T,NM_006005.3:c.-5-201C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,2.321,\N,\N,WFS1
613239,4:6278978:G>A,NM_006005.3:c.-5-200G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,1.031,\N,\N,WFS1
613240,4:6278993:C>T,NM_006005.3:c.-5-185C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,5.088,0.0008,1KG_AFR_AF,WFS1
613241,4:6278997:T>TG,NM_006005.3:c.-5-179dup,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613242,4:6279015:C>T,NM_006005.3:c.-5-163C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,3.209,\N,\N,WFS1
613243,4:6279016:G>A,NM_006005.3:c.-5-162G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.144,0.001,1KG_SAS_AF,WFS1
613244,4:6279019:G>T,NM_006005.3:c.-5-159G>T,\N,\N,1/7,Unknown significance,\N,intron_variant,1.795,0.001,1KG_SAS_AF,WFS1
613245,4:6279023:G>GC,NM_006005.3:c.-5-152dup,\N,\N,1/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613246,4:6279044:T>C,NM_006005.3:c.-5-134T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.693,0.001,1KG_EUR_AF,WFS1
613247,4:6279047:C>T,NM_006005.3:c.-5-131C>T,\N,\N,1/7,Benign,\N,intron_variant,0.719,0.9107,1KG_EAS_AF,WFS1
613248,4:6279059:G>A,NM_006005.3:c.-5-119G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,2.666,\N,\N,WFS1
613249,4:6279093:T>C,NM_006005.3:c.-5-85T>C,\N,\N,1/7,Unknown significance,\N,intron_variant,0.805,\N,\N,WFS1
613250,4:6279117:A>G,NM_006005.3:c.-5-61A>G,\N,\N,1/7,Unknown significance,\N,intron_variant,0.923,0.0014,1KG_AMR_AF,WFS1
613251,4:6279125:C>T,NM_006005.3:c.-5-53C>T,\N,\N,1/7,Unknown significance,\N,intron_variant,7.21,0.0008,1KG_AFR_AF,WFS1
613252,4:6279142:G>A,NM_006005.3:c.-5-36G>A,\N,\N,1/7,Unknown significance,\N,intron_variant,0.759,0.000129836,EXAC_SAS_AF,WFS1
613253,4:6279147:T>A,NM_006005.3:c.-5-31T>A,\N,\N,1/7,Unknown significance,\N,intron_variant,5.57,0.00384615,EXAC_EAS_AF,WFS1
613254,4:6279171:C>T,NM_006005.3:c.-5-7C>T,\N,\N,1/7,Unknown significance,\N,splice_region_variant&intron_variant,8.023,0.001,1KG_SAS_AF,WFS1
613255,4:6279179:C>T,NM_006005.3:c.-4C>T,\N,2/8,\N,Unknown significance,\N,splice_region_variant&5_prime_UTR_variant,8.329,0.000160617,EXAC_NFE_AF,WFS1
613256,4:6279191:C>T,NM_006005.3:c.9C>T,NP_005996.2:p.Ser3=,2/8,\N,Benign,\N,synonymous_variant,8.959,0.0684019,EXAC_AFR_AF,WFS1
613257,4:6279191:C>G,NM_006005.3:c.9C>G,NP_005996.2:p.Ser3=,2/8,\N,Unknown significance,\N,synonymous_variant,6.905,\N,\N,WFS1
613258,4:6279202:C>T,NM_006005.3:c.20C>T,NP_005996.2:p.Pro7Leu,2/8,\N,Unknown significance,\N,missense_variant,24,0.000574053,EXAC_AFR_AF,WFS1
613259,4:6279203:G>T,NM_006005.3:c.21G>T,NP_005996.2:p.Pro7=,2/8,\N,Benign,\N,synonymous_variant,6.289,0.0521,1KG_SAS_AF,WFS1
613260,4:6279206:G>A,NM_006005.3:c.24G>A,NP_005996.2:p.Leu8=,2/8,\N,Unknown significance,\N,synonymous_variant,6.339,\N,\N,WFS1
613261,4:6279208:G>C,NM_006005.3:c.26G>C,NP_005996.2:p.Gly9Ala,2/8,\N,Likely benign,\N,missense_variant,0.505,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
613262,4:6279209:C>A,NM_006005.3:c.27C>A,NP_005996.2:p.Gly9=,2/8,\N,Unknown significance,\N,synonymous_variant,12.84,0.00198413,EXAC_AMR_AF,WFS1
613263,4:6279210:C>T,NM_006005.3:c.28C>T,NP_005996.2:p.Pro10Ser,2/8,\N,Likely benign,\N,missense_variant,19.05,0.000678794,EXAC_NFE_AF,WFS1
613264,4:6279212:C>T,NM_006005.3:c.30C>T,NP_005996.2:p.Pro10=,2/8,\N,Unknown significance,\N,synonymous_variant,9.582,0.000525762,EXAC_AFR_AF,WFS1
613265,4:6279213:T>C,NM_006005.3:c.31T>C,NP_005996.2:p.Ser11Pro,2/8,\N,Unknown significance,\N,missense_variant,6.768,\N,\N,WFS1
613266,4:6279217:G>C,NM_006005.3:c.35G>C,NP_005996.2:p.Cys12Ser,2/8,\N,Likely benign,\N,missense_variant,0.001,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
613267,4:6279223:A>G,NM_006005.3:c.41A>G,NP_005996.2:p.Gln14Arg,2/8,\N,Benign,\N,missense_variant,0.283,0.0248227,EXAC_EAS_AF,WFS1
613268,4:6279224:G>C,NM_006005.3:c.42G>C,NP_005996.2:p.Gln14His,2/8,\N,Likely benign,\N,missense_variant,10.63,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
613269,4:6279225:C>A,NM_006005.3:c.43C>A,NP_005996.2:p.Pro15Thr,2/8,\N,Likely benign,\N,missense_variant,2.045,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
613270,4:6279227:C>T,NM_006005.3:c.45C>T,NP_005996.2:p.Pro15=,2/8,\N,Unknown significance,\N,synonymous_variant,11.77,0.000243843,EXAC_SAS_AF,WFS1
613271,4:6279229:C>T,NM_006005.3:c.47C>T,NP_005996.2:p.Pro16Leu,2/8,\N,Likely benign,\N,missense_variant,22.7,0.00070028,EXAC_EAS_AF,WFS1
613272,4:6279230:G>A,NM_006005.3:c.48G>A,NP_005996.2:p.Pro16=,2/8,\N,Unknown significance,\N,synonymous_variant,7.293,0.00113122,EXAC_AMR_AF,WFS1
613273,4:6279232:C>T,NM_006005.3:c.50C>T,NP_005996.2:p.Pro17Leu,2/8,\N,Likely benign,\N,missense_variant,5.289,0.0000965997,EXAC_NFE_AF,WFS1
613274,4:6279232:C>A,NM_006005.3:c.50C>A,NP_005996.2:p.Pro17Gln,2/8,\N,Likely benign,\N,missense_variant,1.159,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
613275,4:6279236:A>C,NM_006005.3:c.54A>C,NP_005996.2:p.Ala18=,2/8,\N,Unknown significance,\N,synonymous_variant,0.017,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
613276,4:6279237:C>G,NM_006005.3:c.55C>G,NP_005996.2:p.Pro19Ala,2/8,\N,Likely benign,\N,missense_variant,10.65,0.0000909587,EXAC_NFE_AF,WFS1
613277,4:6279238:C>T,NM_006005.3:c.56C>T,NP_005996.2:p.Pro19Leu,2/8,\N,Likely benign,\N,missense_variant,22.6,0.000181028,EXAC_NFE_AF,WFS1
613278,4:6279243:C>A,NM_006005.3:c.61C>A,NP_005996.2:p.Pro21Thr,2/8,\N,Likely benign,\N,missense_variant,20.9,0.00011936,EXAC_SAS_AF,WFS1
613279,4:6279243:C>G,NM_006005.3:c.61C>G,NP_005996.2:p.Pro21Ala,2/8,\N,Likely benign,\N,missense_variant,14.69,0.000169005,EXAC_NFE_AF,WFS1
613280,4:6279251:G>A,NM_006005.3:c.69G>A,NP_005996.2:p.Ala23=,2/8,\N,Unknown significance,\N,synonymous_variant,7.429,0.000714286,EXAC_AFR_AF,WFS1
613281,4:6279252:C>T,NM_006005.3:c.70C>T,NP_005996.2:p.Arg24Cys,2/8,\N,Unknown significance,\N,missense_variant,27.6,0.000117841,EXAC_SAS_AF,WFS1
613282,4:6279253:G>A,NM_006005.3:c.71G>A,NP_005996.2:p.Arg24His,2/8,\N,Unknown significance,\N,missense_variant,25.3,0.00069979,EXAC_AFR_AF,WFS1
613283,4:6279258:C>T,NM_006005.3:c.76C>T,NP_005996.2:p.Arg26Ter,2/8,\N,Unknown significance,\N,stop_gained,35,\N,\N,WFS1
613284,4:6279259:G>A,NM_006005.3:c.77G>A,NP_005996.2:p.Arg26Gln,2/8,\N,Likely benign,\N,missense_variant,11.48,0.00211268,EXAC_AMR_AF,WFS1
613285,4:6279263:C>T,NM_006005.3:c.81C>T,NP_005996.2:p.Leu27=,2/8,\N,Unknown significance,\N,synonymous_variant,9.804,0.0000704225,EXAC_NFE_AF,WFS1
613286,4:6279265:A>G,NM_006005.3:c.83A>G,NP_005996.2:p.Asn28Ser,2/8,\N,Unknown significance,\N,missense_variant,22.4,\N,\N,WFS1
613287,4:6279267:G>C,NM_006005.3:c.85G>C,NP_005996.2:p.Ala29Pro,2/8,\N,Unknown significance,\N,missense_variant,23,\N,\N,WFS1
613288,4:6279273:G>A,NM_006005.3:c.91G>A,NP_005996.2:p.Ala31Thr,2/8,\N,Likely benign,\N,missense_variant,0.08,0.000114916,EXAC_SAS_AF,WFS1
613289,4:6279274:C>G,NM_006005.3:c.92C>G,NP_005996.2:p.Ala31Gly,2/8,\N,Likely benign,\N,missense_variant,13.48,0.0023,1KG_AFR_AF,WFS1
613290,4:6279277:C>T,NM_006005.3:c.95C>T,NP_005996.2:p.Ser32Leu,2/8,\N,Unknown significance,\N,missense_variant,23.5,\N,\N,WFS1
613291,4:6279278:G>A,NM_006005.3:c.96G>A,NP_005996.2:p.Ser32=,2/8,\N,Benign,\N,synonymous_variant,8.486,0.00711634,EXAC_AFR_AF,WFS1
613292,4:6279288:G>C,NM_006005.3:c.106G>C,NP_005996.2:p.Glu36Gln,2/8,\N,Likely benign,\N,missense_variant,10.61,0.0000673582,EXAC_NFE_AF,WFS1
613293,4:6279295:G>A,NM_006005.3:c.113G>A,NP_005996.2:p.Ser38Asn,2/8,\N,Likely benign,\N,missense_variant,1.082,0.000625,EXAC_AMR_AF,WFS1
613294,4:6279295:G>T,NM_006005.3:c.113G>T,NP_005996.2:p.Ser38Ile,2/8,\N,Likely benign,\N,missense_variant,7.813,0.0000684744,EXAC_NFE_AF,WFS1
613295,4:6279296:C>T,NM_006005.3:c.114C>T,NP_005996.2:p.Ser38=,2/8,\N,Unknown significance,\N,synonymous_variant,12.18,0.003141,EXAC_SAS_AF,WFS1
613296,4:6279297:G>T,NM_006005.3:c.115G>T,NP_005996.2:p.Glu39Ter,2/8,\N,Unknown significance,\N,stop_gained,35,0.00011636,EXAC_SAS_AF,WFS1
613297,4:6279300:A>G,NM_006005.3:c.118A>G,NP_005996.2:p.Arg40Gly,2/8,\N,Likely benign,\N,missense_variant,0.046,\N,\N,WFS1
613298,4:6279306:C>T,NM_006005.3:c.124C>T,NP_005996.2:p.Arg42Ter,2/8,\N,Unknown significance,\N,stop_gained,35,0.000367972,EXAC_NFE_AF,WFS1
613299,4:6279307:G>A,NM_006005.3:c.125G>A,NP_005996.2:p.Arg42Gln,2/8,\N,Benign,\N,missense_variant,7.738,0.01,OTO_TR_AF,WFS1
613300,4:6279310:C>T,NM_006005.3:c.128C>T,NP_005996.2:p.Ala43Val,2/8,\N,Likely benign,\N,missense_variant,9.851,\N,\N,WFS1
613301,4:6279311:A>T,NM_006005.3:c.129A>T,NP_005996.2:p.Ala43=,2/8,\N,Unknown significance,\N,synonymous_variant,0.008,0.000224753,EXAC_NFE_AF,WFS1
613302,4:6279311:A>C,NM_006005.3:c.129A>C,NP_005996.2:p.Ala43=,2/8,\N,Unknown significance,\N,synonymous_variant,0.01,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
613303,4:6279312:C>T,NM_006005.3:c.130C>T,NP_005996.2:p.Pro44Ser,2/8,\N,Likely benign,\N,missense_variant,0.217,\N,\N,WFS1
613304,4:6279314:C>A,NM_006005.3:c.132C>A,NP_005996.2:p.Pro44=,2/8,\N,Unknown significance,\N,synonymous_variant,15.13,0.000152835,EXAC_NFE_AF,WFS1
613305,4:6279314:C>T,NM_006005.3:c.132C>T,NP_005996.2:p.Pro44=,2/8,\N,Unknown significance,\N,synonymous_variant,12.23,0.00416667,EXAC_OTH_AF,WFS1
613306,4:6279316:G>T,NM_006005.3:c.134G>T,NP_005996.2:p.Gly45Val,2/8,\N,Unknown significance,\N,missense_variant,23.2,\N,\N,WFS1
613307,4:6279318:C>T,NM_006005.3:c.136C>T,NP_005996.2:p.Pro46Ser,2/8,\N,Likely benign,\N,missense_variant,0.11,\N,\N,WFS1
613308,4:6279322:A>G,NM_006005.3:c.140A>G,NP_005996.2:p.Gln47Arg,2/8,\N,Likely benign,\N,missense_variant,0.009,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
613309,4:6279325:C>T,NM_006005.3:c.143C>T,NP_005996.2:p.Ala48Val,2/8,\N,Likely benign,\N,missense_variant,3.898,\N,\N,WFS1
613310,4:6279325:C>A,NM_006005.3:c.143C>A,NP_005996.2:p.Ala48Asp,2/8,\N,Likely benign,\N,missense_variant,8.875,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
613311,4:6279336:C>A,NM_006005.3:c.154C>A,NP_005996.2:p.Pro52Thr,2/8,\N,Likely benign,\N,missense_variant,4.722,0.00186706,EXAC_AFR_AF,WFS1
613312,4:6279336:C>T,NM_006005.3:c.154C>T,NP_005996.2:p.Pro52Ser,2/8,\N,Likely benign,\N,missense_variant,3.825,0.00186706,EXAC_AFR_AF,WFS1
613313,4:6279341:T>G,NM_006005.3:c.159T>G,NP_005996.2:p.Gly53=,2/8,\N,Unknown significance,\N,synonymous_variant,2.863,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
613314,4:6279350:C>T,NM_006005.3:c.168C>T,NP_005996.2:p.Asp56=,2/8,\N,Unknown significance,\N,synonymous_variant,10.04,\N,\N,WFS1
613315,4:6279351:G>T,NM_006005.3:c.169G>T,NP_005996.2:p.Ala57Ser,2/8,\N,Likely benign,\N,missense_variant,0.003,0.000121007,EXAC_SAS_AF,WFS1
613316,4:6279351:G>A,NM_006005.3:c.169G>A,NP_005996.2:p.Ala57Thr,2/8,\N,Likely benign,\N,missense_variant,0.018,0.000404204,EXAC_AFR_AF,WFS1
613317,4:6279355:C>T,NM_006005.3:c.173C>T,NP_005996.2:p.Ala58Val,2/8,\N,Pathogenic,Wolfram syndrome,missense_variant,12.36,0.00485437,EXAC_OTH_AF,WFS1
613318,4:6279358:C>T,NM_006005.3:c.176C>T,NP_005996.2:p.Ala59Val,2/8,\N,Likely benign,\N,missense_variant,13.12,0.000101937,EXAC_NFE_AF,WFS1
613319,4:6279363:G>A,NM_006005.3:c.181G>A,NP_005996.2:p.Ala61Thr,2/8,\N,Likely benign,\N,missense_variant,8.43,0.000122579,EXAC_SAS_AF,WFS1
613320,4:6279363:G>T,NM_006005.3:c.181G>T,NP_005996.2:p.Ala61Ser,2/8,\N,Likely benign,\N,missense_variant,4.907,0,EXAC_ALL_AF|EXAC_AFR_AF|EXAC_AMR_AF|EXAC_EAS_AF|EXAC_FIN_AF|EXAC_NFE_AF|EXAC_OTH_AF|EXAC_SAS_AF,WFS1
613321,4:6279374:G>A,NM_006005.3:c.192G>A,NP_005996.2:p.Gln64=,2/8,\N,Unknown significance,\N,synonymous_variant,0.04,0.000123335,EXAC_SAS_AF,WFS1
613322,4:6279377:C>T,NM_006005.3:c.195C>T,NP_005996.2:p.Ala65=,2/8,\N,Unknown significance,\N,synonymous_variant,11.27,\N,\N,WFS1
613323,4:6279377:CCAGCATACCAGGAGCCGGGAAA>C,NM_006005.3:c.196_217del,NP_005996.2:p.Gln66GlufsTer70,2/8,\N,Unknown significance,\N,frameshift_variant,26.7,0.00121655,EXAC_AMR_AF,WFS1
613324,4:6279385:C>T,NM_006005.3:c.203C>T,NP_005996.2:p.Thr68Ile,2/8,\N,Likely benign,\N,missense_variant,11.11,\N,\N,WFS1
613325,4:6279393:C>T,NM_006005.3:c.211C>T,NP_005996.2:p.Arg71Trp,2/8,\N,Unknown significance,\N,missense_variant,24.5,0.0005,EXAC_AFR_AF,WFS1
613326,4:6279394:G>A,NM_006005.3:c.212G>A,NP_005996.2:p.Arg71Gln,2/8,\N,Likely benign,\N,missense_variant,8.41,\N,\N,WFS1
613327,4:6279402:G>A,NM_006005.3:c.220G>A,NP_005996.2:p.Ala74Thr,2/8,\N,Likely benign,\N,missense_variant,0.141,0.000124906,EXAC_SAS_AF,WFS1
613328,4:6279407:C>T,NM_006005.3:c.225C>T,NP_005996.2:p.Asp75=,2/8,\N,Benign,\N,synonymous_variant,11.61,0.0171306,EXAC_AFR_AF,WFS1
613329,4:6279408:G>A,NM_006005.3:c.226G>A,NP_005996.2:p.Gly76Ser,2/8,\N,Likely benign,\N,missense_variant,0.708,0.00123457,EXAC_EAS_AF,WFS1
613330,4:6279409:G>T,NM_006005.3:c.227G>T,NP_005996.2:p.Gly76Val,2/8,\N,Benign,\N,missense_variant,3.064,0.00826902,EXAC_AFR_AF,WFS1
613331,4:6279410:C>T,NM_006005.3:c.228C>T,NP_005996.2:p.Gly76=,2/8,\N,Unknown significance,\N,synonymous_variant,7.762,\N,\N,WFS1
613332,4:6279413:C>T,NM_006005.3:c.231C>T,NP_005996.2:p.Thr77=,2/8,\N,Unknown significance,\N,splice_region_variant&synonymous_variant,4.916,0.000563063,EXAC_AFR_AF,WFS1
613333,4:6279414:G>A,NM_006005.3:c.232G>A,NP_005996.2:p.Gly78Arg,2/8,\N,Unknown significance,\N,missense_variant&splice_region_variant,19.27,\N,\N,WFS1
613334,4:6279419:G>A,NM_006005.3:c.232+5G>A,\N,\N,2/7,Benign,\N,splice_region_variant&intron_variant,9.01,0.0111111,EXAC_FIN_AF,WFS1
613335,4:6279428:C>T,NM_006005.3:c.232+14C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.783,\N,\N,WFS1
613336,4:6279429:T>A,NM_006005.3:c.232+15T>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.094,0.000161655,EXAC_NFE_AF,WFS1
613337,4:6279433:A>G,NM_006005.3:c.232+19A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,5.957,0.0008,1KG_AFR_AF,WFS1
613338,4:6279459:T>C,NM_006005.3:c.232+45T>C,\N,\N,2/7,Benign,\N,intron_variant,0.431,0.0235,1KG_SAS_AF,WFS1
613339,4:6279462:C>T,NM_006005.3:c.232+48C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.554,0.00012655,EVS_EA_AF,WFS1
613340,4:6279465:G>A,NM_006005.3:c.232+51G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.03,\N,\N,WFS1
613341,4:6279504:G>A,NM_006005.3:c.232+90G>A,\N,\N,2/7,Benign,\N,intron_variant,0.049,0.9038,1KG_EAS_AF,WFS1
613342,4:6279517:C>T,NM_006005.3:c.232+103C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.948,0.004,1KG_EAS_AF,WFS1
613343,4:6279554:C>T,NM_006005.3:c.232+140C>T,\N,\N,2/7,Benign,\N,intron_variant,1.752,0.0166,1KG_AFR_AF,WFS1
613344,4:6279555:G>A,NM_006005.3:c.232+141G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.438,0.003,1KG_EAS_AF,WFS1
613345,4:6279564:G>A,NM_006005.3:c.232+150G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.97,\N,\N,WFS1
613346,4:6279591:T>C,NM_006005.3:c.232+177T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,3.479,0.001,1KG_EAS_AF,WFS1
613347,4:6279597:T>A,NM_006005.3:c.232+183T>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.609,\N,\N,WFS1
613348,4:6279619:C>T,NM_006005.3:c.232+205C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.379,0.001,1KG_SAS_AF,WFS1
613349,4:6279626:G>A,NM_006005.3:c.232+212G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.099,0.001,1KG_SAS_AF,WFS1
613350,4:6279639:C>A,NM_006005.3:c.232+225C>A,\N,\N,2/7,Benign,\N,intron_variant,1.827,0.0598,1KG_AFR_AF,WFS1
613351,4:6279640:A>G,NM_006005.3:c.232+226A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.079,\N,\N,WFS1
613352,4:6279644:C>A,NM_006005.3:c.232+230C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.004,0.002,1KG_EUR_AF,WFS1
613353,4:6279644:C>T,NM_006005.3:c.232+230C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.174,\N,\N,WFS1
613354,4:6279690:T>C,NM_006005.3:c.232+276T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,2.521,0.004,1KG_EAS_AF,WFS1
613355,4:6279694:T>A,NM_006005.3:c.232+280T>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.335,0.0008,1KG_AFR_AF,WFS1
613356,4:6279697:G>A,NM_006005.3:c.232+283G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.461,\N,\N,WFS1
613357,4:6279704:C>T,NM_006005.3:c.232+290C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.98,0.001,1KG_EUR_AF,WFS1
613358,4:6279706:T>C,NM_006005.3:c.232+292T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,4.287,0.0008,1KG_AFR_AF,WFS1
613359,4:6279742:A>G,NM_006005.3:c.232+328A>G,\N,\N,2/7,Benign,\N,intron_variant,0.578,0.0058,1KG_AMR_AF,WFS1
613360,4:6279746:AC>A,NM_006005.3:c.232+333del,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613361,4:6279753:T>G,NM_006005.3:c.232+339T>G,\N,\N,2/7,Unknown significance,\N,intron_variant,6.772,0.0045,1KG_AFR_AF,WFS1
613362,4:6279770:C>T,NM_006005.3:c.232+356C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.209,0.0008,1KG_AFR_AF,WFS1
613363,4:6279782:C>T,NM_006005.3:c.232+368C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.591,\N,\N,WFS1
613364,4:6279836:T>C,NM_006005.3:c.232+422T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.486,\N,\N,WFS1
613365,4:6279838:A>G,NM_006005.3:c.232+424A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,4.73,0.0041,1KG_SAS_AF,WFS1
613366,4:6279842:A>C,NM_006005.3:c.232+428A>C,\N,\N,2/7,Benign,\N,intron_variant,3.1,0.0061,1KG_AFR_AF,WFS1
613367,4:6279856:C>T,NM_006005.3:c.232+442C>T,\N,\N,2/7,Benign,\N,intron_variant,6.151,0.005,1KG_EUR_AF,WFS1
613368,4:6279860:C>T,NM_006005.3:c.232+446C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.626,0.0015,1KG_AFR_AF,WFS1
613369,4:6279920:G>A,NM_006005.3:c.232+506G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.589,\N,\N,WFS1
613370,4:6279922:C>A,NM_006005.3:c.232+508C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.683,0.001,1KG_SAS_AF,WFS1
613371,4:6279947:G>A,NM_006005.3:c.232+533G>A,\N,\N,2/7,Benign,\N,intron_variant,6.182,0.0091,1KG_AFR_AF,WFS1
613372,4:6279956:G>C,NM_006005.3:c.232+542G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.417,0.0008,1KG_AFR_AF,WFS1
613373,4:6279961:C>T,NM_006005.3:c.232+547C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.795,0.0031,1KG_SAS_AF,WFS1
613374,4:6279964:G>A,NM_006005.3:c.232+550G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.237,\N,\N,WFS1
613375,4:6280024:G>A,NM_006005.3:c.232+610G>A,\N,\N,2/7,Benign,\N,intron_variant,7.241,0.0112,1KG_SAS_AF,WFS1
613376,4:6280040:G>T,NM_006005.3:c.232+626G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.679,\N,\N,WFS1
613377,4:6280072:G>A,NM_006005.3:c.232+658G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.444,\N,\N,WFS1
613378,4:6280108:G>A,NM_006005.3:c.232+694G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.551,0.001,1KG_EUR_AF,WFS1
613379,4:6280120:C>G,NM_006005.3:c.232+706C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.906,\N,\N,WFS1
613380,4:6280136:C>T,NM_006005.3:c.232+722C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,7.815,0.003,1KG_EUR_AF,WFS1
613381,4:6280137:G>A,NM_006005.3:c.232+723G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.443,\N,\N,WFS1
613382,4:6280147:A>C,NM_006005.3:c.232+733A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.289,0.004,1KG_EAS_AF,WFS1
613383,4:6280170:GC>G,NM_006005.3:c.232+760del,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613384,4:6280184:T>G,NM_006005.3:c.232+770T>G,\N,\N,2/7,Unknown significance,\N,intron_variant,7.626,\N,\N,WFS1
613385,4:6280188:G>T,NM_006005.3:c.232+774G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,7.189,\N,\N,WFS1
613386,4:6280235:C>T,NM_006005.3:c.232+821C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.847,\N,\N,WFS1
613387,4:6280240:T>C,NM_006005.3:c.232+826T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.108,0.003,1KG_AFR_AF,WFS1
613388,4:6280320:G>A,NM_006005.3:c.232+906G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,3.446,0.002,1KG_EAS_AF,WFS1
613389,4:6280322:G>C,NM_006005.3:c.232+908G>C,\N,\N,2/7,Benign,\N,intron_variant,3.077,0.0521,1KG_SAS_AF,WFS1
613390,4:6280388:G>A,NM_006005.3:c.232+974G>A,\N,\N,2/7,Benign,\N,intron_variant,3.806,0.0091,1KG_AFR_AF,WFS1
613391,4:6280407:G>A,NM_006005.3:c.232+993G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.408,\N,\N,WFS1
613392,4:6280409:C>T,NM_006005.3:c.232+995C>T,\N,\N,2/7,Benign,\N,intron_variant,6.212,0.0562,1KG_SAS_AF,WFS1
613393,4:6280414:C>T,NM_006005.3:c.232+1000C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.038,\N,\N,WFS1
613394,4:6280415:G>A,NM_006005.3:c.232+1001G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.63,0.0023,1KG_AFR_AF,WFS1
613395,4:6280416:C>T,NM_006005.3:c.232+1002C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.772,\N,\N,WFS1
613396,4:6280434:C>T,NM_006005.3:c.232+1020C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,5.563,\N,\N,WFS1
613397,4:6280444:TG>T,NM_006005.3:c.232+1033del,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613398,4:6280449:G>A,NM_006005.3:c.232+1035G>A,\N,\N,2/7,Benign,\N,intron_variant,2.004,0.9038,1KG_EAS_AF,WFS1
613399,4:6280467:T>C,NM_006005.3:c.232+1053T>C,\N,\N,2/7,Benign,\N,intron_variant,1.857,0.2307,1KG_AFR_AF,WFS1
613400,4:6280547:C>A,NM_006005.3:c.232+1133C>A,\N,\N,2/7,Benign,\N,intron_variant,2.57,0.0091,1KG_AFR_AF,WFS1
613401,4:6280565:C>T,NM_006005.3:c.232+1151C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.417,\N,\N,WFS1
613402,4:6280585:A>G,NM_006005.3:c.232+1171A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.902,0.002,1KG_EAS_AF,WFS1
613403,4:6280586:C>G,NM_006005.3:c.232+1172C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.268,0.001,1KG_EUR_AF,WFS1
613404,4:6280599:A>G,NM_006005.3:c.232+1185A>G,\N,\N,2/7,Benign,\N,intron_variant,1.236,0.0545,1KG_AFR_AF,WFS1
613405,4:6280615:G>A,NM_006005.3:c.232+1201G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.669,0.0031,1KG_SAS_AF,WFS1
613406,4:6280646:C>G,NM_006005.3:c.232+1232C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.082,\N,\N,WFS1
613407,4:6280652:G>A,NM_006005.3:c.232+1238G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.036,0.0014,1KG_AMR_AF,WFS1
613408,4:6280701:A>G,NM_006005.3:c.232+1287A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,5.093,\N,\N,WFS1
613409,4:6280733:A>G,NM_006005.3:c.232+1319A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,0.474,0.001,1KG_EAS_AF,WFS1
613410,4:6280751:G>A,NM_006005.3:c.232+1337G>A,\N,\N,2/7,Benign,\N,intron_variant,5.292,0.0091,1KG_AFR_AF,WFS1
613411,4:6280797:T>C,NM_006005.3:c.232+1383T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,3.186,0.001,1KG_SAS_AF,WFS1
613412,4:6280806:GGG>CCC,NM_006005.3:c.232+1392_232+1394inv,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613413,4:6280822:G>A,NM_006005.3:c.232+1408G>A,\N,\N,2/7,Benign,\N,intron_variant,1.292,0.0461,1KG_AFR_AF,WFS1
613414,4:6280874:C>G,NM_006005.3:c.232+1460C>G,\N,\N,2/7,Benign,\N,intron_variant,3.729,0.0219,1KG_AFR_AF,WFS1
613415,4:6280883:C>T,NM_006005.3:c.232+1469C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.837,0.001,1KG_EAS_AF,WFS1
613416,4:6280897:G>T,NM_006005.3:c.232+1483G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.143,\N,\N,WFS1
613417,4:6280906:T>C,NM_006005.3:c.232+1492T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.576,\N,\N,WFS1
613418,4:6280907:C>T,NM_006005.3:c.232+1493C>T,\N,\N,2/7,Benign,\N,intron_variant,4.029,0.005,1KG_EAS_AF,WFS1
613419,4:6280936:T>C,NM_006005.3:c.232+1522T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.229,\N,\N,WFS1
613420,4:6280955:C>G,NM_006005.3:c.232+1541C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.684,\N,\N,WFS1
613421,4:6280969:T>A,NM_006005.3:c.232+1555T>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.612,0,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,WFS1
613422,4:6280983:T>C,NM_006005.3:c.232+1569T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.736,0.003,1KG_EUR_AF,WFS1
613423,4:6281009:G>T,NM_006005.3:c.232+1595G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.147,\N,\N,WFS1
613424,4:6281010:G>T,NM_006005.3:c.232+1596G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.346,0.001,1KG_SAS_AF,WFS1
613425,4:6281034:C>T,NM_006005.3:c.232+1620C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.602,\N,\N,WFS1
613426,4:6281035:G>A,NM_006005.3:c.232+1621G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.615,\N,\N,WFS1
613427,4:6281043:C>T,NM_006005.3:c.232+1629C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.158,0.001,1KG_SAS_AF,WFS1
613428,4:6281084:C>T,NM_006005.3:c.232+1670C>T,\N,\N,2/7,Benign,\N,intron_variant,1.358,0.0112,1KG_SAS_AF,WFS1
613429,4:6281129:C>T,NM_006005.3:c.232+1715C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.531,0.0014,1KG_AMR_AF,WFS1
613430,4:6281130:G>A,NM_006005.3:c.232+1716G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.135,0.002,1KG_SAS_AF,WFS1
613431,4:6281133:G>A,NM_006005.3:c.232+1719G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.856,\N,\N,WFS1
613432,4:6281162:G>A,NM_006005.3:c.232+1748G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.037,0.0008,1KG_AFR_AF,WFS1
613433,4:6281179:G>A,NM_006005.3:c.232+1765G>A,\N,\N,2/7,Benign,\N,intron_variant,6.019,0.0061,1KG_AFR_AF,WFS1
613434,4:6281181:G>A,NM_006005.3:c.232+1767G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.737,\N,\N,WFS1
613435,4:6281188:G>A,NM_006005.3:c.232+1774G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.539,\N,\N,WFS1
613436,4:6281199:C>T,NM_006005.3:c.232+1785C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,5.612,\N,\N,WFS1
613437,4:6281223:A>G,NM_006005.3:c.232+1809A>G,\N,\N,2/7,Benign,\N,intron_variant,1.048,0.0521,1KG_SAS_AF,WFS1
613438,4:6281234:G>A,NM_006005.3:c.232+1820G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.571,\N,\N,WFS1
613439,4:6281239:C>T,NM_006005.3:c.232+1825C>T,\N,\N,2/7,Benign,\N,intron_variant,3.57,0.0129,1KG_AFR_AF,WFS1
613440,4:6281243:G>A,NM_006005.3:c.232+1829G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.803,0.001,1KG_SAS_AF,WFS1
613441,4:6281278:G>A,NM_006005.3:c.232+1864G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.968,0.002,1KG_EUR_AF,WFS1
613442,4:6281293:G>A,NM_006005.3:c.232+1879G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.637,\N,\N,WFS1
613443,4:6281301:C>T,NM_006005.3:c.232+1887C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.751,0.0015,1KG_AFR_AF,WFS1
613444,4:6281321:G>A,NM_006005.3:c.232+1907G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.044,\N,\N,WFS1
613445,4:6281326:G>T,NM_006005.3:c.232+1912G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.262,\N,\N,WFS1
613446,4:6281407:C>A,NM_006005.3:c.232+1993C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.916,\N,\N,WFS1
613447,4:6281412:G>A,NM_006005.3:c.232+1998G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.419,\N,\N,WFS1
613448,4:6281413:C>T,NM_006005.3:c.232+1999C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.837,\N,\N,WFS1
613449,4:6281414:T>C,NM_006005.3:c.232+2000T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,3.27,\N,\N,WFS1
613450,4:6281419:T>A,NM_006005.3:c.232+2005T>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.35,\N,\N,WFS1
613451,4:6281423:G>T,NM_006005.3:c.232+2009G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.467,0.0014,1KG_AMR_AF,WFS1
613452,4:6281448:C>T,NM_006005.3:c.232+2034C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.757,0.0014,1KG_AMR_AF,WFS1
613453,4:6281448:CCCTAGGGGCA>C,NM_006005.3:c.232+2037_232+2046del,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613454,4:6281449:C>T,NM_006005.3:c.232+2035C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,5.462,\N,\N,WFS1
613455,4:6281457:CA>C,NM_006005.3:c.232+2044del,\N,\N,2/7,Benign,\N,intron_variant,6.158,0.0076,1KG_AFR_AF,WFS1
613456,4:6281458:A>C,NM_006005.3:c.232+2044A>C,\N,\N,2/7,Benign,\N,intron_variant,1.749,0.996,1KG_EAS_AF,WFS1
613457,4:6281461:C>T,NM_006005.3:c.232+2047C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.809,0.0008,1KG_AFR_AF,WFS1
613458,4:6281465:G>A,NM_006005.3:c.232+2051G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.171,0.003,1KG_AFR_AF,WFS1
613459,4:6281484:A>T,NM_006005.3:c.232+2070A>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.895,\N,\N,WFS1
613460,4:6281490:T>A,NM_006005.3:c.232+2076T>A,\N,\N,2/7,Unknown significance,\N,intron_variant,9.009,0.001,1KG_EAS_AF,WFS1
613461,4:6281496:A>G,NM_006005.3:c.232+2082A>G,\N,\N,2/7,Benign,\N,intron_variant,1.919,0.996,1KG_EAS_AF,WFS1
613462,4:6281525:C>G,NM_006005.3:c.232+2111C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.166,\N,\N,WFS1
613463,4:6281563:C>T,NM_006005.3:c.232+2149C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.121,\N,\N,WFS1
613464,4:6281619:C>T,NM_006005.3:c.232+2205C>T,\N,\N,2/7,Benign,\N,intron_variant,8.177,0.0123,1KG_SAS_AF,WFS1
613465,4:6281633:C>T,NM_006005.3:c.232+2219C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.461,0.0008,1KG_AFR_AF,WFS1
613466,4:6281671:C>T,NM_006005.3:c.232+2257C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.014,\N,\N,WFS1
613467,4:6281677:T>G,NM_006005.3:c.232+2263T>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.358,0.0008,1KG_AFR_AF,WFS1
613468,4:6281685:A>G,NM_006005.3:c.232+2271A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,5.449,0.001,1KG_EAS_AF,WFS1
613469,4:6281688:C>G,NM_006005.3:c.232+2274C>G,\N,\N,2/7,Benign,\N,intron_variant,4.733,0.005,1KG_EUR_AF,WFS1
613470,4:6281720:C>T,NM_006005.3:c.232+2306C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,19.71,0.0031,1KG_SAS_AF,WFS1
613471,4:6281728:G>C,NM_006005.3:c.232+2314G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,15.91,0.001,1KG_EAS_AF,WFS1
613472,4:6281740:C>T,NM_006005.3:c.232+2326C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.135,0.0014,1KG_AMR_AF,WFS1
613473,4:6281744:G>A,NM_006005.3:c.232+2330G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.105,0.002,1KG_SAS_AF,WFS1
613474,4:6281745:G>A,NM_006005.3:c.232+2331G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.871,\N,\N,WFS1
613475,4:6281756:A>G,NM_006005.3:c.232+2342A>G,\N,\N,2/7,Benign,\N,intron_variant,1.848,0.996,1KG_EAS_AF,WFS1
613476,4:6281764:G>A,NM_006005.3:c.232+2350G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.779,\N,\N,WFS1
613477,4:6281765:G>A,NM_006005.3:c.232+2351G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.768,\N,\N,WFS1
613478,4:6281767:G>C,NM_006005.3:c.232+2353G>C,\N,\N,2/7,Benign,\N,intron_variant,1.509,0.0166,1KG_AFR_AF,WFS1
613479,4:6281775:G>A,NM_006005.3:c.232+2361G>A,\N,\N,2/7,Benign,\N,intron_variant,2.447,0.9077,1KG_EAS_AF,WFS1
613480,4:6281775:GCT>ACC,NM_006005.3:c.232+2361_232+2363delinsACC,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613481,4:6281778:C>CAG,NM_006005.3:c.232+2365_232+2366dup,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613482,4:6281778:CAG>C,NM_006005.3:c.232+2365_232+2366del,\N,\N,2/7,Benign,\N,intron_variant,7.007,0.1084,1KG_SAS_AF,WFS1
613483,4:6281783:G>T,NM_006005.3:c.232+2369G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.159,0.0008,1KG_AFR_AF,WFS1
613484,4:6281817:C>T,NM_006005.3:c.232+2403C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,5.035,\N,\N,WFS1
613485,4:6281821:G>A,NM_006005.3:c.232+2407G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.599,0.0008,1KG_AFR_AF,WFS1
613486,4:6281871:C>T,NM_006005.3:c.232+2457C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.138,\N,\N,WFS1
613487,4:6281878:G>A,NM_006005.3:c.232+2464G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.088,0.001,1KG_EAS_AF,WFS1
613488,4:6281882:C>G,NM_006005.3:c.232+2468C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,4.882,\N,\N,WFS1
613489,4:6281895:C>A,NM_006005.3:c.232+2481C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,10.4,0.0008,1KG_AFR_AF,WFS1
613490,4:6281912:G>A,NM_006005.3:c.232+2498G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,8.301,0.001,1KG_EAS_AF,WFS1
613491,4:6281919:G>C,NM_006005.3:c.232+2505G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,3.561,\N,\N,WFS1
613492,4:6281927:C>T,NM_006005.3:c.232+2513C>T,\N,\N,2/7,Benign,\N,intron_variant,1.559,0.1906,1KG_AFR_AF,WFS1
613493,4:6281938:A>G,NM_006005.3:c.232+2524A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,0.682,\N,\N,WFS1
613494,4:6281955:G>T,NM_006005.3:c.232+2541G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.442,0.002,1KG_EAS_AF,WFS1
613495,4:6281961:C>T,NM_006005.3:c.232+2547C>T,\N,\N,2/7,Benign,\N,intron_variant,1.698,0.996,1KG_EAS_AF,WFS1
613496,4:6281975:G>C,NM_006005.3:c.232+2561G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,2.352,\N,\N,WFS1
613497,4:6281983:A>G,NM_006005.3:c.232+2569A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.437,0.001,1KG_EUR_AF,WFS1
613498,4:6282038:C>T,NM_006005.3:c.232+2624C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.994,\N,\N,WFS1
613499,4:6282049:G>A,NM_006005.3:c.232+2635G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.966,\N,\N,WFS1
613500,4:6282054:G>A,NM_006005.3:c.232+2640G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.218,0.0015,1KG_AFR_AF,WFS1
613501,4:6282054:G>T,NM_006005.3:c.232+2640G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.48,\N,\N,WFS1
613502,4:6282071:T>A,NM_006005.3:c.232+2657T>A,\N,\N,2/7,Benign,\N,intron_variant,10.05,0.0123,1KG_SAS_AF,WFS1
613503,4:6282112:T>TGG,NM_006005.3:c.232+2703_232+2704dup,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613504,4:6282138:A>G,NM_006005.3:c.232+2724A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,0.167,0.002,1KG_EAS_AF,WFS1
613505,4:6282157:T>C,NM_006005.3:c.232+2743T>C,\N,\N,2/7,Benign,\N,intron_variant,0.03,0.9077,1KG_EAS_AF,WFS1
613506,4:6282158:G>C,NM_006005.3:c.232+2744G>C,\N,\N,2/7,Benign,\N,intron_variant,0.01,0.0399,1KG_SAS_AF,WFS1
613507,4:6282173:A>G,NM_006005.3:c.232+2759A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.607,0.0014,1KG_AMR_AF,WFS1
613508,4:6282185:AG>A,NM_006005.3:c.232+2773del,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613509,4:6282189:A>T,NM_006005.3:c.232+2775A>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.561,0.0008,1KG_AFR_AF,WFS1
613510,4:6282228:C>T,NM_006005.3:c.232+2814C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.153,0.0014,1KG_AMR_AF,WFS1
613511,4:6282237:G>A,NM_006005.3:c.232+2823G>A,\N,\N,2/7,Benign,\N,intron_variant,2.899,0.0521,1KG_SAS_AF,WFS1
613512,4:6282243:C>T,NM_006005.3:c.232+2829C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.216,\N,\N,WFS1
613513,4:6282272:C>G,NM_006005.3:c.232+2858C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,8.799,\N,\N,WFS1
613514,4:6282276:G>T,NM_006005.3:c.232+2862G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,7.033,\N,\N,WFS1
613515,4:6282307:C>T,NM_006005.3:c.232+2893C>T,\N,\N,2/7,Benign,\N,intron_variant,5.557,0.1104,1KG_AFR_AF,WFS1
613516,4:6282313:C>G,NM_006005.3:c.232+2899C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.312,\N,\N,WFS1
613517,4:6282315:G>C,NM_006005.3:c.232+2901G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.841,\N,\N,WFS1
613518,4:6282337:G>A,NM_006005.3:c.232+2923G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.42,0.002,1KG_SAS_AF,WFS1
613519,4:6282340:C>T,NM_006005.3:c.232+2926C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.601,0.001,1KG_EAS_AF,WFS1
613520,4:6282341:A>G,NM_006005.3:c.232+2927A>G,\N,\N,2/7,Benign,\N,intron_variant,0.095,0.23,1KG_AFR_AF,WFS1
613521,4:6282390:G>T,NM_006005.3:c.232+2976G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.967,\N,\N,WFS1
613522,4:6282392:C>G,NM_006005.3:c.232+2978C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,0.716,\N,\N,WFS1
613523,4:6282393:A>G,NM_006005.3:c.232+2979A>G,\N,\N,2/7,Benign,\N,intron_variant,1.011,0.996,1KG_EAS_AF,WFS1
613524,4:6282411:G>A,NM_006005.3:c.232+2997G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.951,0.001,1KG_SAS_AF,WFS1
613525,4:6282418:C>CTGTGCTAAGTG,NM_006005.3:c.232+3014_232+3024dup,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613526,4:6282418:CTGTGCTAAGTG>C,NM_006005.3:c.232+3014_232+3024del,\N,\N,2/7,Benign,\N,intron_variant,6.966,0.1074,1KG_SAS_AF,WFS1
613527,4:6282420:G>T,NM_006005.3:c.232+3006G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.272,0.001,1KG_SAS_AF,WFS1
613528,4:6282428:T>C,NM_006005.3:c.232+3014T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.007,\N,\N,WFS1
613529,4:6282429:G>A,NM_006005.3:c.232+3015G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.704,\N,\N,WFS1
613530,4:6282450:G>C,NM_006005.3:c.232+3036G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.701,0.001,1KG_SAS_AF,WFS1
613531,4:6282455:G>C,NM_006005.3:c.232+3041G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.739,\N,\N,WFS1
613532,4:6282456:C>G,NM_006005.3:c.232+3042C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.721,0.001,1KG_EUR_AF,WFS1
613533,4:6282473:T>C,NM_006005.3:c.232+3059T>C,\N,\N,2/7,Benign,\N,intron_variant,0.371,0.9077,1KG_EAS_AF,WFS1
613534,4:6282481:G>A,NM_006005.3:c.232+3067G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.557,0.001,1KG_SAS_AF,WFS1
613535,4:6282515:C>A,NM_006005.3:c.232+3101C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.449,\N,\N,WFS1
613536,4:6282516:T>G,NM_006005.3:c.232+3102T>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.487,\N,\N,WFS1
613537,4:6282520:C>T,NM_006005.3:c.232+3106C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.55,0.0008,1KG_AFR_AF,WFS1
613538,4:6282529:C>G,NM_006005.3:c.232+3115C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,0.968,\N,\N,WFS1
613539,4:6282590:G>A,NM_006005.3:c.232+3176G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,3.871,\N,\N,WFS1
613540,4:6282596:C>T,NM_006005.3:c.232+3182C>T,\N,\N,2/7,Benign,\N,intron_variant,3.226,0.9038,1KG_EAS_AF,WFS1
613541,4:6282613:G>A,NM_006005.3:c.232+3199G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.148,0.001,1KG_SAS_AF,WFS1
613542,4:6282618:C>T,NM_006005.3:c.232+3204C>T,\N,\N,2/7,Benign,\N,intron_variant,0.495,0.0061,1KG_SAS_AF,WFS1
613543,4:6282681:C>T,NM_006005.3:c.232+3267C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.176,0.003,1KG_EUR_AF,WFS1
613544,4:6282682:G>A,NM_006005.3:c.232+3268G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.155,\N,\N,WFS1
613545,4:6282739:G>A,NM_006005.3:c.232+3325G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,11.33,0.002,1KG_EUR_AF,WFS1
613546,4:6282745:C>T,NM_006005.3:c.232+3331C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,11.92,0.0014,1KG_AMR_AF,WFS1
613547,4:6282752:C>T,NM_006005.3:c.232+3338C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,13.94,0.001,1KG_SAS_AF,WFS1
613548,4:6282757:C>T,NM_006005.3:c.232+3343C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,13.12,\N,\N,WFS1
613549,4:6282761:T>C,NM_006005.3:c.232+3347T>C,\N,\N,2/7,Benign,\N,intron_variant,11.43,0.0053,1KG_AFR_AF,WFS1
613550,4:6282767:C>T,NM_006005.3:c.232+3353C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,11,0.001,1KG_SAS_AF,WFS1
613551,4:6282778:C>A,NM_006005.3:c.232+3364C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.674,0.0023,1KG_AFR_AF,WFS1
613552,4:6282788:G>A,NM_006005.3:c.232+3374G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,3.502,0.0008,1KG_AFR_AF,WFS1
613553,4:6282818:T>C,NM_006005.3:c.232+3404T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,2.004,0.001,1KG_EUR_AF,WFS1
613554,4:6282824:G>A,NM_006005.3:c.232+3410G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.228,0.0008,1KG_AFR_AF,WFS1
613555,4:6282846:C>T,NM_006005.3:c.232+3432C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,10.91,0.002,1KG_EUR_AF,WFS1
613556,4:6282900:A>G,NM_006005.3:c.232+3486A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,5.567,0.001,1KG_EAS_AF,WFS1
613557,4:6282905:G>A,NM_006005.3:c.232+3491G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.569,0.0015,1KG_AFR_AF,WFS1
613558,4:6282911:C>T,NM_006005.3:c.232+3497C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.895,0.001,1KG_SAS_AF,WFS1
613559,4:6283004:G>T,NM_006005.3:c.232+3590G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.294,0.002,1KG_SAS_AF,WFS1
613560,4:6283068:G>A,NM_006005.3:c.232+3654G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,8.703,\N,\N,WFS1
613561,4:6283079:T>G,NM_006005.3:c.232+3665T>G,\N,\N,2/7,Unknown significance,\N,intron_variant,5,\N,\N,WFS1
613562,4:6283110:GC>G,NM_006005.3:c.232+3699del,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613563,4:6283121:C>A,NM_006005.3:c.232+3707C>A,\N,\N,2/7,Benign,\N,intron_variant,6.971,0.1053,1KG_SAS_AF,WFS1
613564,4:6283138:A>G,NM_006005.3:c.232+3724A>G,\N,\N,2/7,Benign,\N,intron_variant,0.259,0.1053,1KG_SAS_AF,WFS1
613565,4:6283142:TCGTG>T,NM_006005.3:c.232+3729_232+3732del,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613566,4:6283143:C>T,NM_006005.3:c.232+3729C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.2,0.0008,1KG_AFR_AF,WFS1
613567,4:6283143:CGTGA>C,NM_006005.3:c.232+3733_232+3736del,\N,\N,2/7,Benign,\N,intron_variant,3.538,0.0461,1KG_AFR_AF,WFS1
613568,4:6283144:GTGA>G,NM_006005.3:c.232+3731_232+3733del,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613569,4:6283148:G>T,NM_006005.3:c.232+3734G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.54,\N,\N,WFS1
613570,4:6283153:G>A,NM_006005.3:c.232+3739G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.411,0.001,1KG_EUR_AF,WFS1
613571,4:6283158:G>C,NM_006005.3:c.232+3744G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.244,\N,\N,WFS1
613572,4:6283199:C>T,NM_006005.3:c.232+3785C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.498,0.004,1KG_EUR_AF,WFS1
613573,4:6283200:G>A,NM_006005.3:c.232+3786G>A,\N,\N,2/7,Benign,\N,intron_variant,4.221,0.0613,1KG_AFR_AF,WFS1
613574,4:6283235:C>T,NM_006005.3:c.232+3821C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,9.693,\N,\N,WFS1
613575,4:6283237:G>C,NM_006005.3:c.232+3823G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,6.79,0.0014,1KG_AMR_AF,WFS1
613576,4:6283253:T>C,NM_006005.3:c.232+3839T>C,\N,\N,2/7,Benign,\N,intron_variant,4.417,0.996,1KG_EAS_AF,WFS1
613577,4:6283254:G>A,NM_006005.3:c.232+3840G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,8.069,0.0008,1KG_AFR_AF,WFS1
613578,4:6283266:G>A,NM_006005.3:c.232+3852G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,7.113,0.0008,1KG_AFR_AF,WFS1
613579,4:6283309:C>T,NM_006005.3:c.232+3895C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.825,0.0008,1KG_AFR_AF,WFS1
613580,4:6283319:A>ACAGCC,NM_006005.3:c.232+3906_232+3910dup,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613581,4:6283330:T>C,NM_006005.3:c.232+3916T>C,\N,\N,2/7,Benign,\N,intron_variant,5.283,0.0083,1KG_AFR_AF,WFS1
613582,4:6283337:C>T,NM_006005.3:c.232+3923C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.471,\N,\N,WFS1
613583,4:6283351:C>T,NM_006005.3:c.232+3937C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.161,0.001,1KG_EUR_AF,WFS1
613584,4:6283353:G>C,NM_006005.3:c.232+3939G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.609,\N,\N,WFS1
613585,4:6283354:C>T,NM_006005.3:c.232+3940C>T,\N,\N,2/7,Benign,\N,intron_variant,0.657,0.1043,1KG_SAS_AF,WFS1
613586,4:6283364:G>A,NM_006005.3:c.232+3950G>A,\N,\N,2/7,Benign,\N,intron_variant,4.447,0.056,1KG_AFR_AF,WFS1
613587,4:6283388:G>A,NM_006005.3:c.232+3974G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.792,\N,\N,WFS1
613588,4:6283391:C>G,NM_006005.3:c.232+3977C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.423,\N,\N,WFS1
613589,4:6283431:C>A,NM_006005.3:c.232+4017C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.082,0.001,1KG_SAS_AF,WFS1
613590,4:6283433:G>A,NM_006005.3:c.232+4019G>A,\N,\N,2/7,Benign,\N,intron_variant,1.322,0.1043,1KG_SAS_AF,WFS1
613591,4:6283460:C>T,NM_006005.3:c.232+4046C>T,\N,\N,2/7,Benign,\N,intron_variant,4.676,0.996,1KG_EAS_AF,WFS1
613592,4:6283468:G>GGT,NM_006005.3:c.232+4056_232+4057dup,\N,\N,2/7,Benign,\N,intron_variant,1.203,0.0083,1KG_AFR_AF,WFS1
613593,4:6283473:T>C,NM_006005.3:c.232+4059T>C,\N,\N,2/7,Benign,\N,intron_variant,2.258,0.1043,1KG_SAS_AF,WFS1
613594,4:6283487:A>G,NM_006005.3:c.232+4073A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,4.6,0.001,1KG_SAS_AF,WFS1
613595,4:6283545:C>G,NM_006005.3:c.232+4131C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,11.91,0.003,1KG_AFR_AF,WFS1
613596,4:6283561:T>C,NM_006005.3:c.232+4147T>C,\N,\N,2/7,Benign,\N,intron_variant,5.732,0.0265,1KG_AFR_AF,WFS1
613597,4:6283590:G>C,NM_006005.3:c.232+4176G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.452,\N,\N,WFS1
613598,4:6283615:T>G,NM_006005.3:c.232+4201T>G,\N,\N,2/7,Benign,\N,intron_variant,5.284,0.0521,1KG_SAS_AF,WFS1
613599,4:6283627:G>C,NM_006005.3:c.232+4213G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.714,\N,\N,WFS1
613600,4:6283657:G>A,NM_006005.3:c.232+4243G>A,\N,\N,2/7,Benign,\N,intron_variant,2.944,0.1043,1KG_SAS_AF,WFS1
613601,4:6283683:G>A,NM_006005.3:c.232+4269G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.704,0.001,1KG_EUR_AF,WFS1
613602,4:6283688:C>A,NM_006005.3:c.232+4274C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.714,\N,\N,WFS1
613603,4:6283691:C>T,NM_006005.3:c.232+4277C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.177,0.0014,1KG_AMR_AF,WFS1
613604,4:6283706:G>A,NM_006005.3:c.232+4292G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.168,\N,\N,WFS1
613605,4:6283720:A>G,NM_006005.3:c.232+4306A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.076,\N,\N,WFS1
613606,4:6283729:C>A,NM_006005.3:c.232+4315C>A,\N,\N,2/7,Benign,\N,intron_variant,5.81,0.0265,1KG_AFR_AF,WFS1
613607,4:6283759:G>A,NM_006005.3:c.232+4345G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,3.647,0.0023,1KG_AFR_AF,WFS1
613608,4:6283819:G>A,NM_006005.3:c.232+4405G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,8.07,0.0015,1KG_AFR_AF,WFS1
613609,4:6283820:G>T,NM_006005.3:c.232+4406G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.741,0.0031,1KG_SAS_AF,WFS1
613610,4:6283824:C>A,NM_006005.3:c.232+4410C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,8.267,\N,\N,WFS1
613611,4:6283824:C>T,NM_006005.3:c.232+4410C>T,\N,\N,2/7,Benign,\N,intron_variant,8.177,0.0613,1KG_AFR_AF,WFS1
613612,4:6283844:T>G,NM_006005.3:c.232+4430T>G,\N,\N,2/7,Benign,\N,intron_variant,11.96,0.0058,1KG_AMR_AF,WFS1
613613,4:6283854:G>T,NM_006005.3:c.232+4440G>T,\N,\N,2/7,Benign,\N,intron_variant,9.485,0.008,1KG_EUR_AF,WFS1
613614,4:6283860:G>GC,NM_006005.3:c.232+4448dup,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613615,4:6283867:G>A,NM_006005.3:c.232+4453G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,7.959,0.0023,1KG_AFR_AF,WFS1
613616,4:6283919:G>A,NM_006005.3:c.232+4505G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.026,\N,\N,WFS1
613617,4:6283928:C>G,NM_006005.3:c.232+4514C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,5.293,0.001,1KG_EUR_AF,WFS1
613618,4:6283949:G>A,NM_006005.3:c.232+4535G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.692,0.0015,1KG_AFR_AF,WFS1
613619,4:6283984:T>C,NM_006005.3:c.232+4570T>C,\N,\N,2/7,Benign,\N,intron_variant,5.839,0.056,1KG_AFR_AF,WFS1
613620,4:6284012:C>T,NM_006005.3:c.232+4598C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,7.42,0.001,1KG_SAS_AF,WFS1
613621,4:6284024:G>A,NM_006005.3:c.232+4610G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,8.515,\N,\N,WFS1
613622,4:6284028:C>T,NM_006005.3:c.232+4614C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.353,\N,\N,WFS1
613623,4:6284029:G>A,NM_006005.3:c.232+4615G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.045,0.0008,1KG_AFR_AF,WFS1
613624,4:6284031:C>T,NM_006005.3:c.232+4617C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.933,0.0029,1KG_AMR_AF,WFS1
613625,4:6284032:G>A,NM_006005.3:c.232+4618G>A,\N,\N,2/7,Benign,\N,intron_variant,1.635,0.0308,1KG_EAS_AF,WFS1
613626,4:6284126:C>T,NM_006005.3:c.233-4694C>T,\N,\N,2/7,Benign,\N,intron_variant,5.659,0.0082,1KG_SAS_AF,WFS1
613627,4:6284145:C>T,NM_006005.3:c.233-4675C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.258,0.001,1KG_EAS_AF,WFS1
613628,4:6284150:C>G,NM_006005.3:c.233-4670C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.393,\N,\N,WFS1
613629,4:6284150:C>T,NM_006005.3:c.233-4670C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.402,\N,\N,WFS1
613630,4:6284151:G>A,NM_006005.3:c.233-4669G>A,\N,\N,2/7,Benign,\N,intron_variant,5.289,0.0308,1KG_EUR_AF,WFS1
613631,4:6284152:A>G,NM_006005.3:c.233-4668A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.25,\N,\N,WFS1
613632,4:6284158:G>A,NM_006005.3:c.233-4662G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.254,\N,\N,WFS1
613633,4:6284158:G>T,NM_006005.3:c.233-4662G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.42,\N,\N,WFS1
613634,4:6284169:G>A,NM_006005.3:c.233-4651G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.629,0.001,1KG_SAS_AF,WFS1
613635,4:6284202:G>A,NM_006005.3:c.233-4618G>A,\N,\N,2/7,Benign,\N,intron_variant,7.86,0.056,1KG_AFR_AF,WFS1
613636,4:6284236:C>T,NM_006005.3:c.233-4584C>T,\N,\N,2/7,Benign,\N,intron_variant,4.573,0.1043,1KG_SAS_AF,WFS1
613637,4:6284243:A>T,NM_006005.3:c.233-4577A>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.079,0.0015,1KG_AFR_AF,WFS1
613638,4:6284252:T>C,NM_006005.3:c.233-4568T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.443,0.001,1KG_SAS_AF,WFS1
613639,4:6284266:A>G,NM_006005.3:c.233-4554A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.052,0.0015,1KG_AFR_AF,WFS1
613640,4:6284277:C>T,NM_006005.3:c.233-4543C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.19,0.001,1KG_EUR_AF|1KG_SAS_AF,WFS1
613641,4:6284278:G>A,NM_006005.3:c.233-4542G>A,\N,\N,2/7,Benign,\N,intron_variant,3.872,0.0109,1KG_EUR_AF,WFS1
613642,4:6284288:G>A,NM_006005.3:c.233-4532G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,3.485,0.002,1KG_EUR_AF,WFS1
613643,4:6284308:A>G,NM_006005.3:c.233-4512A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.9,0.001,1KG_EUR_AF,WFS1
613644,4:6284321:A>C,NM_006005.3:c.233-4499A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.101,0.001,1KG_SAS_AF,WFS1
613645,4:6284326:G>A,NM_006005.3:c.233-4494G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.152,0.002,1KG_EUR_AF,WFS1
613646,4:6284399:A>C,NM_006005.3:c.233-4421A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.236,\N,\N,WFS1
613647,4:6284449:T>C,NM_006005.3:c.233-4371T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.988,\N,\N,WFS1
613648,4:6284461:G>A,NM_006005.3:c.233-4359G>A,\N,\N,2/7,Benign,\N,intron_variant,2.352,0.059,1KG_AFR_AF,WFS1
613649,4:6284499:C>T,NM_006005.3:c.233-4321C>T,\N,\N,2/7,Benign,\N,intron_variant,4.09,0.006,1KG_EAS_AF,WFS1
613650,4:6284581:T>C,NM_006005.3:c.233-4239T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,2.212,\N,\N,WFS1
613651,4:6284623:T>C,NM_006005.3:c.233-4197T>C,\N,\N,2/7,Benign,\N,intron_variant,6.427,0.0119,1KG_EUR_AF,WFS1
613652,4:6284633:A>G,NM_006005.3:c.233-4187A>G,\N,\N,2/7,Benign,\N,intron_variant,5.68,0.996,1KG_EAS_AF,WFS1
613653,4:6284658:C>A,NM_006005.3:c.233-4162C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.146,\N,\N,WFS1
613654,4:6284687:G>A,NM_006005.3:c.233-4133G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.746,0.003,1KG_EAS_AF,WFS1
613655,4:6284689:C>T,NM_006005.3:c.233-4131C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.956,\N,\N,WFS1
613656,4:6284690:G>A,NM_006005.3:c.233-4130G>A,\N,\N,2/7,Benign,\N,intron_variant,3.452,0.0143,1KG_SAS_AF,WFS1
613657,4:6284707:C>T,NM_006005.3:c.233-4113C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.867,\N,\N,WFS1
613658,4:6284708:G>A,NM_006005.3:c.233-4112G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.022,\N,\N,WFS1
613659,4:6284726:G>A,NM_006005.3:c.233-4094G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.641,0.001,1KG_SAS_AF,WFS1
613660,4:6284728:A>G,NM_006005.3:c.233-4092A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.702,0.0014,1KG_AMR_AF,WFS1
613661,4:6284739:A>G,NM_006005.3:c.233-4081A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.799,\N,\N,WFS1
613662,4:6284754:C>T,NM_006005.3:c.233-4066C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,5.854,0.001,1KG_SAS_AF,WFS1
613663,4:6284778:G>A,NM_006005.3:c.233-4042G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.275,0.0015,1KG_AFR_AF,WFS1
613664,4:6284791:C>A,NM_006005.3:c.233-4029C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,3.907,\N,\N,WFS1
613665,4:6284791:C>G,NM_006005.3:c.233-4029C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.725,\N,\N,WFS1
613666,4:6284801:A>G,NM_006005.3:c.233-4019A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.295,\N,\N,WFS1
613667,4:6284802:T>C,NM_006005.3:c.233-4018T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,3.787,\N,\N,WFS1
613668,4:6284808:T>G,NM_006005.3:c.233-4012T>G,\N,\N,2/7,Unknown significance,\N,intron_variant,5.987,\N,\N,WFS1
613669,4:6284812:C>G,NM_006005.3:c.233-4008C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,5.291,\N,\N,WFS1
613670,4:6284818:C>T,NM_006005.3:c.233-4002C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.379,0.002,1KG_EAS_AF,WFS1
613671,4:6284819:G>A,NM_006005.3:c.233-4001G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,3.967,0.002,1KG_EAS_AF,WFS1
613672,4:6284888:C>T,NM_006005.3:c.233-3932C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.562,\N,\N,WFS1
613673,4:6284889:G>A,NM_006005.3:c.233-3931G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.817,0.002,1KG_SAS_AF,WFS1
613674,4:6284921:C>G,NM_006005.3:c.233-3899C>G,\N,\N,2/7,Benign,\N,intron_variant,2.094,0.0492,1KG_AFR_AF,WFS1
613675,4:6284924:G>A,NM_006005.3:c.233-3896G>A,\N,\N,2/7,Benign,\N,intron_variant,2.191,0.0514,1KG_AFR_AF,WFS1
613676,4:6284950:T>A,NM_006005.3:c.233-3870T>A,\N,\N,2/7,Benign,\N,intron_variant,3.872,0.0257,1KG_AFR_AF,WFS1
613677,4:6284962:C>T,NM_006005.3:c.233-3858C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,6.082,\N,\N,WFS1
613678,4:6284965:A>G,NM_006005.3:c.233-3855A>G,\N,\N,2/7,Benign,\N,intron_variant,2.517,0.996,1KG_EAS_AF,WFS1
613679,4:6284993:C>T,NM_006005.3:c.233-3827C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.14,\N,\N,WFS1
613680,4:6284994:C>T,NM_006005.3:c.233-3826C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.095,0.004,1KG_EAS_AF,WFS1
613681,4:6285043:C>T,NM_006005.3:c.233-3777C>T,\N,\N,2/7,Benign,\N,intron_variant,5.914,0.056,1KG_AFR_AF,WFS1
613682,4:6285056:A>G,NM_006005.3:c.233-3764A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,8.128,0.001,1KG_EAS_AF,WFS1
613683,4:6285057:G>A,NM_006005.3:c.233-3763G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.906,0.0038,1KG_AFR_AF,WFS1
613684,4:6285071:C>T,NM_006005.3:c.233-3749C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,9.765,0.001,1KG_EAS_AF,WFS1
613685,4:6285081:G>A,NM_006005.3:c.233-3739G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.22,\N,\N,WFS1
613686,4:6285101:A>G,NM_006005.3:c.233-3719A>G,\N,\N,2/7,Benign,\N,intron_variant,0.256,0.0257,1KG_AFR_AF,WFS1
613687,4:6285105:A>G,NM_006005.3:c.233-3715A>G,\N,\N,2/7,Benign,\N,intron_variant,0.27,0.0123,1KG_SAS_AF,WFS1
613688,4:6285124:G>C,NM_006005.3:c.233-3696G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.323,\N,\N,WFS1
613689,4:6285188:C>T,NM_006005.3:c.233-3632C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.365,0.001,1KG_EAS_AF,WFS1
613690,4:6285189:G>A,NM_006005.3:c.233-3631G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.86,0.0014,1KG_AMR_AF,WFS1
613691,4:6285196:T>C,NM_006005.3:c.233-3624T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,2.661,\N,\N,WFS1
613692,4:6285228:C>G,NM_006005.3:c.233-3592C>G,\N,\N,2/7,Benign,\N,intron_variant,1.562,0.9077,1KG_EAS_AF,WFS1
613693,4:6285231:C>G,NM_006005.3:c.233-3589C>G,\N,\N,2/7,Benign,\N,intron_variant,1.8,0.1043,1KG_SAS_AF,WFS1
613694,4:6285234:C>T,NM_006005.3:c.233-3586C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.368,0.003,1KG_AFR_AF,WFS1
613695,4:6285235:G>A,NM_006005.3:c.233-3585G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.777,\N,\N,WFS1
613696,4:6285268:G>A,NM_006005.3:c.233-3552G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.319,0.0015,1KG_AFR_AF,WFS1
613697,4:6285323:C>T,NM_006005.3:c.233-3497C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.97,0.001,1KG_SAS_AF,WFS1
613698,4:6285324:G>A,NM_006005.3:c.233-3496G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.491,\N,\N,WFS1
613699,4:6285380:C>T,NM_006005.3:c.233-3440C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.59,\N,\N,WFS1
613700,4:6285418:C>T,NM_006005.3:c.233-3402C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,7.603,0.0008,1KG_AFR_AF,WFS1
613701,4:6285441:G>A,NM_006005.3:c.233-3379G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.656,0.0023,1KG_AFR_AF,WFS1
613702,4:6285444:T>C,NM_006005.3:c.233-3376T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,4.963,\N,\N,WFS1
613703,4:6285460:C>T,NM_006005.3:c.233-3360C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.284,\N,\N,WFS1
613704,4:6285461:G>A,NM_006005.3:c.233-3359G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.078,0.0045,1KG_AFR_AF,WFS1
613705,4:6285465:C>T,NM_006005.3:c.233-3355C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.078,0.0008,1KG_AFR_AF,WFS1
613706,4:6285498:C>A,NM_006005.3:c.233-3322C>A,\N,\N,2/7,Benign,\N,intron_variant,2.044,0.0613,1KG_AFR_AF,WFS1
613707,4:6285506:A>G,NM_006005.3:c.233-3314A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,0.758,0.002,1KG_SAS_AF,WFS1
613708,4:6285523:C>CG,NM_006005.3:c.233-3293dup,\N,\N,2/7,Unknown significance,\N,intron_variant,1.676,\N,\N,WFS1
613709,4:6285566:A>T,NM_006005.3:c.233-3254A>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.953,\N,\N,WFS1
613710,4:6285575:C>T,NM_006005.3:c.233-3245C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.539,\N,\N,WFS1
613711,4:6285576:G>A,NM_006005.3:c.233-3244G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.273,\N,\N,WFS1
613712,4:6285582:C>T,NM_006005.3:c.233-3238C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.51,0.0015,1KG_AFR_AF,WFS1
613713,4:6285595:A>G,NM_006005.3:c.233-3225A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.365,0.003,1KG_AFR_AF,WFS1
613714,4:6285599:C>T,NM_006005.3:c.233-3221C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.089,\N,\N,WFS1
613715,4:6285600:G>A,NM_006005.3:c.233-3220G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,3.479,\N,\N,WFS1
613716,4:6285602:G>T,NM_006005.3:c.233-3218G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.29,\N,\N,WFS1
613717,4:6285612:G>T,NM_006005.3:c.233-3208G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.226,0.001,1KG_SAS_AF,WFS1
613718,4:6285639:C>G,NM_006005.3:c.233-3181C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.805,0.0008,1KG_AFR_AF,WFS1
613719,4:6285640:G>A,NM_006005.3:c.233-3180G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.892,\N,\N,WFS1
613720,4:6285642:C>T,NM_006005.3:c.233-3178C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.89,0.0014,1KG_AMR_AF,WFS1
613721,4:6285659:T>G,NM_006005.3:c.233-3161T>G,\N,\N,2/7,Benign,\N,intron_variant,3.079,0.0416,1KG_AFR_AF,WFS1
613722,4:6285679:A>C,NM_006005.3:c.233-3141A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.238,0.001,1KG_SAS_AF,WFS1
613723,4:6285705:G>A,NM_006005.3:c.233-3115G>A,\N,\N,2/7,Benign,\N,intron_variant,1.752,0.0136,1KG_AFR_AF,WFS1
613724,4:6285709:G>T,NM_006005.3:c.233-3111G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.905,0.0008,1KG_AFR_AF,WFS1
613725,4:6285715:A>G,NM_006005.3:c.233-3105A>G,\N,\N,2/7,Benign,\N,intron_variant,4.068,0.996,1KG_EAS_AF,WFS1
613726,4:6285734:C>T,NM_006005.3:c.233-3086C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.466,0.001,1KG_EUR_AF,WFS1
613727,4:6285738:T>C,NM_006005.3:c.233-3082T>C,\N,\N,2/7,Benign,\N,intron_variant,0.579,0.0058,1KG_AMR_AF,WFS1
613728,4:6285747:C>T,NM_006005.3:c.233-3073C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.067,0.0014,1KG_AMR_AF,WFS1
613729,4:6285748:G>A,NM_006005.3:c.233-3072G>A,\N,\N,2/7,Benign,\N,intron_variant,0.38,0.056,1KG_AFR_AF,WFS1
613730,4:6285755:C>A,NM_006005.3:c.233-3065C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.058,0.001,1KG_EUR_AF,WFS1
613731,4:6285762:C>T,NM_006005.3:c.233-3058C>T,\N,\N,2/7,Benign,\N,intron_variant,4.141,0.0389,1KG_AMR_AF,WFS1
613732,4:6285764:T>C,NM_006005.3:c.233-3056T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.007,0.001,1KG_EUR_AF,WFS1
613733,4:6285765:A>G,NM_006005.3:c.233-3055A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.51,\N,\N,WFS1
613734,4:6285789:G>A,NM_006005.3:c.233-3031G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.06,0.0015,1KG_AFR_AF,WFS1
613735,4:6285797:C>A,NM_006005.3:c.233-3023C>A,\N,\N,2/7,Benign,\N,intron_variant,0.93,0.9038,1KG_EAS_AF,WFS1
613736,4:6285855:T>A,NM_006005.3:c.233-2965T>A,\N,\N,2/7,Benign,\N,intron_variant,7.826,0.0091,1KG_AFR_AF,WFS1
613737,4:6285873:G>T,NM_006005.3:c.233-2947G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.612,\N,\N,WFS1
613738,4:6285878:C>T,NM_006005.3:c.233-2942C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.179,\N,\N,WFS1
613739,4:6285885:T>C,NM_006005.3:c.233-2935T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.446,\N,\N,WFS1
613740,4:6285895:G>A,NM_006005.3:c.233-2925G>A,\N,\N,2/7,Benign,\N,intron_variant,0.544,0.9077,1KG_EAS_AF,WFS1
613741,4:6285911:A>C,NM_006005.3:c.233-2909A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,4.767,\N,\N,WFS1
613742,4:6285948:A>C,NM_006005.3:c.233-2872A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.293,\N,\N,WFS1
613743,4:6285968:C>T,NM_006005.3:c.233-2852C>T,\N,\N,2/7,Benign,\N,intron_variant,0.331,0.0521,1KG_SAS_AF,WFS1
613744,4:6285972:C>T,NM_006005.3:c.233-2848C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.133,\N,\N,WFS1
613745,4:6285973:G>A,NM_006005.3:c.233-2847G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.638,\N,\N,WFS1
613746,4:6286033:G>A,NM_006005.3:c.233-2787G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.478,0.0008,1KG_AFR_AF,WFS1
613747,4:6286044:G>A,NM_006005.3:c.233-2776G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.075,0.001,1KG_EUR_AF,WFS1
613748,4:6286056:T>C,NM_006005.3:c.233-2764T>C,\N,\N,2/7,Benign,\N,intron_variant,0.316,0.0133,1KG_SAS_AF,WFS1
613749,4:6286078:C>T,NM_006005.3:c.233-2742C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.894,0.002,1KG_EUR_AF,WFS1
613750,4:6286087:T>C,NM_006005.3:c.233-2733T>C,\N,\N,2/7,Benign,\N,intron_variant,0.238,0.996,1KG_EAS_AF,WFS1
613751,4:6286088:G>A,NM_006005.3:c.233-2732G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.092,0.001,1KG_EUR_AF|1KG_SAS_AF,WFS1
613752,4:6286136:A>G,NM_006005.3:c.233-2684A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,0.622,0.003,1KG_AFR_AF,WFS1
613753,4:6286140:C>CG,NM_006005.3:c.233-2676dup,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613754,4:6286140:C>T,NM_006005.3:c.233-2680C>T,\N,\N,2/7,Benign,\N,intron_variant,1.709,0.1082,1KG_AFR_AF,WFS1
613755,4:6286158:T>C,NM_006005.3:c.233-2662T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,12.26,\N,\N,WFS1
613756,4:6286175:C>G,NM_006005.3:c.233-2645C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,9.706,\N,\N,WFS1
613757,4:6286212:T>C,NM_006005.3:c.233-2608T>C,\N,\N,2/7,Benign,\N,intron_variant,2.083,0.056,1KG_AFR_AF,WFS1
613758,4:6286222:C>A,NM_006005.3:c.233-2598C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.215,0.002,1KG_SAS_AF,WFS1
613759,4:6286236:C>A,NM_006005.3:c.233-2584C>A,\N,\N,2/7,Benign,\N,intron_variant,1.916,0.0143,1KG_SAS_AF,WFS1
613760,4:6286288:C>T,NM_006005.3:c.233-2532C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.348,\N,\N,WFS1
613761,4:6286299:T>C,NM_006005.3:c.233-2521T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.201,0.0008,1KG_AFR_AF,WFS1
613762,4:6286303:G>A,NM_006005.3:c.233-2517G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.79,\N,\N,WFS1
613763,4:6286317:C>A,NM_006005.3:c.233-2503C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.96,\N,\N,WFS1
613764,4:6286318:T>C,NM_006005.3:c.233-2502T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.871,0.0015,1KG_AFR_AF,WFS1
613765,4:6286388:A>G,NM_006005.3:c.233-2432A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.118,0.004,1KG_EAS_AF,WFS1
613766,4:6286410:C>T,NM_006005.3:c.233-2410C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.471,\N,\N,WFS1
613767,4:6286429:A>T,NM_006005.3:c.233-2391A>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.296,\N,\N,WFS1
613768,4:6286434:A>G,NM_006005.3:c.233-2386A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.099,\N,\N,WFS1
613769,4:6286449:A>G,NM_006005.3:c.233-2371A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,0.098,0.0043,1KG_AMR_AF,WFS1
613770,4:6286460:T>A,NM_006005.3:c.233-2360T>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.194,\N,\N,WFS1
613771,4:6286471:T>C,NM_006005.3:c.233-2349T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.237,0.001,1KG_EUR_AF,WFS1
613772,4:6286481:G>A,NM_006005.3:c.233-2339G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.795,\N,\N,WFS1
613773,4:6286485:A>G,NM_006005.3:c.233-2335A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.125,0.001,1KG_EUR_AF,WFS1
613774,4:6286501:G>A,NM_006005.3:c.233-2319G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.918,0.0008,1KG_AFR_AF,WFS1
613775,4:6286503:A>T,NM_006005.3:c.233-2317A>T,\N,\N,2/7,Benign,\N,intron_variant,1.412,0.0348,1KG_AFR_AF,WFS1
613776,4:6286528:C>T,NM_006005.3:c.233-2292C>T,\N,\N,2/7,Benign,\N,intron_variant,3.103,0.9038,1KG_EAS_AF,WFS1
613777,4:6286544:G>A,NM_006005.3:c.233-2276G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,3.598,\N,\N,WFS1
613778,4:6286566:C>T,NM_006005.3:c.233-2254C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.882,0.0023,1KG_AFR_AF,WFS1
613779,4:6286567:G>A,NM_006005.3:c.233-2253G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.996,\N,\N,WFS1
613780,4:6286569:C>G,NM_006005.3:c.233-2251C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.575,\N,\N,WFS1
613781,4:6286600:T>C,NM_006005.3:c.233-2220T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.063,\N,\N,WFS1
613782,4:6286620:C>G,NM_006005.3:c.233-2200C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.363,\N,\N,WFS1
613783,4:6286626:G>T,NM_006005.3:c.233-2194G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.117,0.0008,1KG_AFR_AF,WFS1
613784,4:6286667:C>T,NM_006005.3:c.233-2153C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,7.366,\N,\N,WFS1
613785,4:6286674:C>T,NM_006005.3:c.233-2146C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.975,0.0015,1KG_AFR_AF,WFS1
613786,4:6286690:G>A,NM_006005.3:c.233-2130G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.835,\N,\N,WFS1
613787,4:6286694:G>C,NM_006005.3:c.233-2126G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.358,0.003,1KG_AFR_AF,WFS1
613788,4:6286711:C>A,NM_006005.3:c.233-2109C>A,\N,\N,2/7,Benign,\N,intron_variant,2.667,0.9038,1KG_EAS_AF,WFS1
613789,4:6286711:C>G,NM_006005.3:c.233-2109C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.423,\N,\N,WFS1
613790,4:6286711:C>T,NM_006005.3:c.233-2109C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.707,\N,\N,WFS1
613791,4:6286757:A>C,NM_006005.3:c.233-2063A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,3.337,0.003,1KG_AFR_AF,WFS1
613792,4:6286779:G>A,NM_006005.3:c.233-2041G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.085,0.001,1KG_EAS_AF,WFS1
613793,4:6286805:C>T,NM_006005.3:c.233-2015C>T,\N,\N,2/7,Benign,\N,intron_variant,1.985,0.0102,1KG_SAS_AF,WFS1
613794,4:6286806:G>A,NM_006005.3:c.233-2014G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.237,\N,\N,WFS1
613795,4:6286818:C>T,NM_006005.3:c.233-2002C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,5.86,\N,\N,WFS1
613796,4:6286827:G>A,NM_006005.3:c.233-1993G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.091,\N,\N,WFS1
613797,4:6286831:C>T,NM_006005.3:c.233-1989C>T,\N,\N,2/7,Benign,\N,intron_variant,0.724,0.0068,1KG_AFR_AF,WFS1
613798,4:6286838:G>A,NM_006005.3:c.233-1982G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.371,\N,\N,WFS1
613799,4:6286846:C>T,NM_006005.3:c.233-1974C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.959,0.0008,1KG_AFR_AF,WFS1
613800,4:6286847:G>T,NM_006005.3:c.233-1973G>T,\N,\N,2/7,Benign,\N,intron_variant,0.118,0.9077,1KG_EAS_AF,WFS1
613801,4:6286884:G>A,NM_006005.3:c.233-1936G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,3.199,\N,\N,WFS1
613802,4:6286886:G>A,NM_006005.3:c.233-1934G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.292,\N,\N,WFS1
613803,4:6286886:GTCCAGGGAGAGTTACA>G,NM_006005.3:c.233-1918_233-1903del,\N,\N,2/7,Benign,\N,intron_variant,7.641,0.0736,1KG_SAS_AF,WFS1
613804,4:6286902:A>ATCCAGGGAGAGTTACG,NM_006005.3:c.233-1906_233-1891dup,\N,\N,2/7,Benign,\N,intron_variant,0.084,0.5119,1KG_EAS_AF,WFS1
613805,4:6286902:A>G,NM_006005.3:c.233-1918A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.089,\N,\N,WFS1
613806,4:6286903:T>TTCCAGGGAGAGTTACG,NM_006005.3:c.233-1917_233-1916insTCCAGGGAGAGTTACG,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613807,4:6286914:T>TTTACGTCCAGGGAGAG,NM_006005.3:c.233-1905_233-1904insTACGTCCAGGGAGAGT,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613808,4:6286917:C>G,NM_006005.3:c.233-1903C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.445,\N,\N,WFS1
613809,4:6286917:C>T,NM_006005.3:c.233-1903C>T,\N,\N,2/7,Benign,\N,intron_variant,2.878,0.0123,1KG_SAS_AF,WFS1
613810,4:6286929:G>GTTAC,NM_006005.3:c.233-1891_233-1890insTTAC,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613811,4:6286930:G>T,NM_006005.3:c.233-1890G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.746,\N,\N,WFS1
613812,4:6286931:G>T,NM_006005.3:c.233-1889G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.787,\N,\N,WFS1
613813,4:6286932:G>A,NM_006005.3:c.233-1888G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.777,\N,\N,WFS1
613814,4:6286933:C>T,NM_006005.3:c.233-1887C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.11,0.002,1KG_SAS_AF,WFS1
613815,4:6286941:A>G,NM_006005.3:c.233-1879A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.128,\N,\N,WFS1
613816,4:6286954:A>C,NM_006005.3:c.233-1866A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.904,\N,\N,WFS1
613817,4:6286954:A>G,NM_006005.3:c.233-1866A>G,\N,\N,2/7,Benign,\N,intron_variant,1.907,0.9038,1KG_EAS_AF,WFS1
613818,4:6286954:A>T,NM_006005.3:c.233-1866A>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.315,\N,\N,WFS1
613819,4:6286976:G>A,NM_006005.3:c.233-1844G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.473,0.0014,1KG_AMR_AF,WFS1
613820,4:6286991:GGGGACATCCAGGGAGA>G,NM_006005.3:c.233-1825_233-1810del,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,0.003,1KG_AFR_AF,WFS1
613821,4:6286993:G>C,NM_006005.3:c.233-1827G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.118,\N,\N,WFS1
613822,4:6287012:C>T,NM_006005.3:c.233-1808C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.573,0.0014,1KG_AMR_AF,WFS1
613823,4:6287020:G>C,NM_006005.3:c.233-1800G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.182,0.001,1KG_SAS_AF,WFS1
613824,4:6287033:A>C,NM_006005.3:c.233-1787A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.598,\N,\N,WFS1
613825,4:6287033:A>G,NM_006005.3:c.233-1787A>G,\N,\N,2/7,Benign,\N,intron_variant,2.791,0.3046,1KG_EAS_AF,WFS1
613826,4:6287033:A>T,NM_006005.3:c.233-1787A>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.208,\N,\N,WFS1
613827,4:6287035:G>A,NM_006005.3:c.233-1785G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.446,\N,\N,WFS1
613828,4:6287037:A>T,NM_006005.3:c.233-1783A>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.534,\N,\N,WFS1
613829,4:6287060:C>T,NM_006005.3:c.233-1760C>T,\N,\N,2/7,Benign,\N,intron_variant,3.595,0.0166,1KG_AFR_AF,WFS1
613830,4:6287069:A>T,NM_006005.3:c.233-1751A>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.136,\N,\N,WFS1
613831,4:6287084:G>A,NM_006005.3:c.233-1736G>A,\N,\N,2/7,Benign,\N,intron_variant,4.007,0.0119,1KG_EUR_AF,WFS1
613832,4:6287117:A>G,NM_006005.3:c.233-1703A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.817,0.0023,1KG_AFR_AF,WFS1
613833,4:6287161:G>T,NM_006005.3:c.233-1659G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.285,\N,\N,WFS1
613834,4:6287169:G>A,NM_006005.3:c.233-1651G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.392,\N,\N,WFS1
613835,4:6287173:T>C,NM_006005.3:c.233-1647T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,4.998,0.003,1KG_EAS_AF,WFS1
613836,4:6287197:G>C,NM_006005.3:c.233-1623G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.014,0.0015,1KG_AFR_AF,WFS1
613837,4:6287241:T>C,NM_006005.3:c.233-1579T>C,\N,\N,2/7,Benign,\N,intron_variant,1.892,0.9077,1KG_EAS_AF,WFS1
613838,4:6287244:T>A,NM_006005.3:c.233-1576T>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.747,\N,\N,WFS1
613839,4:6287305:G>A,NM_006005.3:c.233-1515G>A,\N,\N,2/7,Benign,\N,intron_variant,0.887,0.0098,1KG_AFR_AF,WFS1
613840,4:6287309:T>G,NM_006005.3:c.233-1511T>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.167,\N,\N,WFS1
613841,4:6287329:C>T,NM_006005.3:c.233-1491C>T,\N,\N,2/7,Benign,\N,intron_variant,6.188,0.9077,1KG_EAS_AF,WFS1
613842,4:6287336:C>T,NM_006005.3:c.233-1484C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.255,\N,\N,WFS1
613843,4:6287365:C>T,NM_006005.3:c.233-1455C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,5.222,0.0015,1KG_AFR_AF,WFS1
613844,4:6287415:C>A,NM_006005.3:c.233-1405C>A,\N,\N,2/7,Unknown significance,\N,intron_variant,7.135,\N,\N,WFS1
613845,4:6287415:C>G,NM_006005.3:c.233-1405C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,5.626,\N,\N,WFS1
613846,4:6287456:C>T,NM_006005.3:c.233-1364C>T,\N,\N,2/7,Benign,\N,intron_variant,2.168,0.996,1KG_EAS_AF,WFS1
613847,4:6287490:G>T,NM_006005.3:c.233-1330G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.581,0.0008,1KG_AFR_AF,WFS1
613848,4:6287539:C>T,NM_006005.3:c.233-1281C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,4.279,\N,\N,WFS1
613849,4:6287543:G>T,NM_006005.3:c.233-1277G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.325,0.001,1KG_EUR_AF,WFS1
613850,4:6287551:T>G,NM_006005.3:c.233-1269T>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.029,\N,\N,WFS1
613851,4:6287562:C>T,NM_006005.3:c.233-1258C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,5.425,\N,\N,WFS1
613852,4:6287579:TG>T,NM_006005.3:c.233-1240del,\N,\N,2/7,Unknown significance,\N,intron_variant,3.537,0.0023,1KG_AFR_AF,WFS1
613853,4:6287594:G>A,NM_006005.3:c.233-1226G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.578,\N,\N,WFS1
613854,4:6287595:G>A,NM_006005.3:c.233-1225G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.838,0.0014,1KG_AMR_AF,WFS1
613855,4:6287613:C>T,NM_006005.3:c.233-1207C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.935,\N,\N,WFS1
613856,4:6287642:C>T,NM_006005.3:c.233-1178C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.481,\N,\N,WFS1
613857,4:6287653:A>G,NM_006005.3:c.233-1167A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,0.57,\N,\N,WFS1
613858,4:6287676:A>C,NM_006005.3:c.233-1144A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.201,\N,\N,WFS1
613859,4:6287709:A>G,NM_006005.3:c.233-1111A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,3.667,0.0023,1KG_AFR_AF,WFS1
613860,4:6287713:C>G,NM_006005.3:c.233-1107C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.048,\N,\N,WFS1
613861,4:6287731:C>G,NM_006005.3:c.233-1089C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.184,\N,\N,WFS1
613862,4:6287736:C>T,NM_006005.3:c.233-1084C>T,\N,\N,2/7,Benign,\N,intron_variant,2.384,0.0545,1KG_AFR_AF,WFS1
613863,4:6287766:C>T,NM_006005.3:c.233-1054C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.258,\N,\N,WFS1
613864,4:6287767:G>A,NM_006005.3:c.233-1053G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.642,\N,\N,WFS1
613865,4:6287775:CAA>C,NM_006005.3:c.233-1044_233-1043del,\N,\N,2/7,Unknown significance,\N,intron_variant,6.953,0.003,1KG_EUR_AF,WFS1
613866,4:6287785:T>C,NM_006005.3:c.233-1035T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.025,0.001,1KG_SAS_AF,WFS1
613867,4:6287799:C>T,NM_006005.3:c.233-1021C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.232,0.003,1KG_AFR_AF,WFS1
613868,4:6287855:T>A,NM_006005.3:c.233-965T>A,\N,\N,2/7,Unknown significance,\N,intron_variant,6.071,\N,\N,WFS1
613869,4:6287890:G>A,NM_006005.3:c.233-930G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,2.097,0.001,1KG_SAS_AF,WFS1
613870,4:6287895:G>A,NM_006005.3:c.233-925G>A,\N,\N,2/7,Benign,\N,intron_variant,0.292,0.0091,1KG_AFR_AF,WFS1
613871,4:6287928:C>G,NM_006005.3:c.233-892C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,7.041,0.001,1KG_EUR_AF,WFS1
613872,4:6287965:G>A,NM_006005.3:c.233-855G>A,\N,\N,2/7,Benign,\N,intron_variant,1.718,0.9077,1KG_EAS_AF,WFS1
613873,4:6287976:C>G,NM_006005.3:c.233-844C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.606,\N,\N,WFS1
613874,4:6287985:G>A,NM_006005.3:c.233-835G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,7.689,0.0015,1KG_AFR_AF,WFS1
613875,4:6288003:C>T,NM_006005.3:c.233-817C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,10.02,0.001,1KG_EAS_AF,WFS1
613876,4:6288011:G>A,NM_006005.3:c.233-809G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,9.426,0,1KG_ALL_AF|1KG_AFR_AF|1KG_AMR_AF|1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,WFS1
613877,4:6288026:C>T,NM_006005.3:c.233-794C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.33,0.0014,1KG_AMR_AF,WFS1
613878,4:6288038:G>A,NM_006005.3:c.233-782G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.521,\N,\N,WFS1
613879,4:6288056:A>G,NM_006005.3:c.233-764A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,1.55,0.0014,1KG_AMR_AF,WFS1
613880,4:6288080:C>T,NM_006005.3:c.233-740C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.651,0.001,1KG_SAS_AF,WFS1
613881,4:6288145:A>G,NM_006005.3:c.233-675A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.247,\N,\N,WFS1
613882,4:6288148:C>T,NM_006005.3:c.233-672C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.594,0.001,1KG_SAS_AF,WFS1
613883,4:6288152:G>C,NM_006005.3:c.233-668G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.356,0.001,1KG_SAS_AF,WFS1
613884,4:6288179:C>T,NM_006005.3:c.233-641C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.921,\N,\N,WFS1
613885,4:6288192:T>A,NM_006005.3:c.233-628T>A,\N,\N,2/7,Unknown significance,\N,intron_variant,4.892,0.0014,1KG_AMR_AF,WFS1
613886,4:6288193:C>G,NM_006005.3:c.233-627C>G,\N,\N,2/7,Benign,\N,intron_variant,0.169,0.1036,1KG_AFR_AF,WFS1
613887,4:6288227:C>T,NM_006005.3:c.233-593C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,8.629,\N,\N,WFS1
613888,4:6288238:A>G,NM_006005.3:c.233-582A>G,\N,\N,2/7,Benign,\N,intron_variant,9.813,0.1012,1KG_SAS_AF,WFS1
613889,4:6288248:T>C,NM_006005.3:c.233-572T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,8.859,\N,\N,WFS1
613890,4:6288259:T>C,NM_006005.3:c.233-561T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,5.845,0.0008,1KG_AFR_AF,WFS1
613891,4:6288263:A>C,NM_006005.3:c.233-557A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,2.126,0.002,1KG_EAS_AF,WFS1
613892,4:6288268:G>A,NM_006005.3:c.233-552G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.217,\N,\N,WFS1
613893,4:6288293:A>G,NM_006005.3:c.233-527A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.701,0.001,1KG_EAS_AF,WFS1
613894,4:6288298:GA>G,NM_006005.3:c.233-518del,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613895,4:6288306:A>G,NM_006005.3:c.233-514A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,6.815,0.004,1KG_EAS_AF,WFS1
613896,4:6288317:G>A,NM_006005.3:c.233-503G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,9.587,0.0008,1KG_AFR_AF,WFS1
613897,4:6288333:TA>T,NM_006005.3:c.233-485del,\N,\N,2/7,Benign,\N,intron_variant,6.82,0.0159,1KG_AMR_AF,WFS1
613898,4:6288344:A>C,NM_006005.3:c.233-476A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.443,0.001,1KG_EUR_AF|1KG_SAS_AF,WFS1
613899,4:6288351:G>T,NM_006005.3:c.233-469G>T,\N,\N,2/7,Benign,\N,intron_variant,0.282,0.005,1KG_EUR_AF,WFS1
613900,4:6288360:G>A,NM_006005.3:c.233-460G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,0.966,0.002,1KG_EAS_AF,WFS1
613901,4:6288368:C>T,NM_006005.3:c.233-452C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.32,\N,\N,WFS1
613902,4:6288373:A>G,NM_006005.3:c.233-447A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.334,\N,\N,WFS1
613903,4:6288391:G>C,NM_006005.3:c.233-429G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.304,0.0008,1KG_AFR_AF,WFS1
613904,4:6288409:G>A,NM_006005.3:c.233-411G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.536,0.001,1KG_SAS_AF,WFS1
613905,4:6288410:G>C,NM_006005.3:c.233-410G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.535,\N,\N,WFS1
613906,4:6288435:G>C,NM_006005.3:c.233-385G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,0.492,\N,\N,WFS1
613907,4:6288448:A>C,NM_006005.3:c.233-372A>C,\N,\N,2/7,Unknown significance,\N,intron_variant,3.253,0.002,1KG_EAS_AF,WFS1
613908,4:6288497:G>A,NM_006005.3:c.233-323G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,5.038,\N,\N,WFS1
613909,4:6288514:T>C,NM_006005.3:c.233-306T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,8.002,0.002,1KG_SAS_AF,WFS1
613910,4:6288528:G>A,NM_006005.3:c.233-292G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,8.171,\N,\N,WFS1
613911,4:6288534:G>T,NM_006005.3:c.233-286G>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.414,0.0008,1KG_AFR_AF,WFS1
613912,4:6288562:C>T,NM_006005.3:c.233-258C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,1.01,0.0014,1KG_AMR_AF,WFS1
613913,4:6288563:G>A,NM_006005.3:c.233-257G>A,\N,\N,2/7,Benign,\N,intron_variant,0.668,0.0058,1KG_AMR_AF,WFS1
613914,4:6288564:C>G,NM_006005.3:c.233-256C>G,\N,\N,2/7,Unknown significance,\N,intron_variant,2.374,\N,\N,WFS1
613915,4:6288585:C>G,NM_006005.3:c.233-235C>G,\N,\N,2/7,Benign,\N,intron_variant,3.319,0.0082,1KG_SAS_AF,WFS1
613916,4:6288615:T>C,NM_006005.3:c.233-205T>C,\N,\N,2/7,Unknown significance,\N,intron_variant,1.856,0.001,1KG_EUR_AF,WFS1
613917,4:6288620:C>T,NM_006005.3:c.233-200C>T,\N,\N,2/7,Benign,\N,intron_variant,1.075,0.0208,1KG_EAS_AF,WFS1
613918,4:6288630:G>A,NM_006005.3:c.233-190G>A,\N,\N,2/7,Benign,\N,intron_variant,1.223,0.005,1KG_EAS_AF,WFS1
613919,4:6288681:G>GTC,NM_006005.3:c.233-133_233-132dup,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613920,4:6288691:A>G,NM_006005.3:c.233-129A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,6.126,0.004,1KG_EAS_AF,WFS1
613921,4:6288695:C>T,NM_006005.3:c.233-125C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,9.498,0.001,1KG_EAS_AF,WFS1
613922,4:6288720:C>CAG,NM_006005.3:c.233-99_233-98dup,\N,\N,2/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613923,4:6288725:G>A,NM_006005.3:c.233-95G>A,\N,\N,2/7,Unknown significance,\N,intron_variant,1.952,0.0015,1KG_AFR_AF,WFS1
613924,4:6288740:C>T,NM_006005.3:c.233-80C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,2.733,\N,\N,WFS1
613925,4:6288747:C>T,NM_006005.3:c.233-73C>T,\N,\N,2/7,Unknown significance,\N,intron_variant,3.432,0.0008,1KG_AFR_AF,WFS1
613926,4:6288759:A>T,NM_006005.3:c.233-61A>T,\N,\N,2/7,Unknown significance,\N,intron_variant,0.619,0.0008,1KG_AFR_AF,WFS1
613927,4:6288775:A>G,NM_006005.3:c.233-45A>G,\N,\N,2/7,Unknown significance,\N,intron_variant,0.751,\N,\N,WFS1
613928,4:6288787:G>C,NM_006005.3:c.233-33G>C,\N,\N,2/7,Unknown significance,\N,intron_variant,3.245,0.000235849,EVS_AA_AF,WFS1
613929,4:6288791:CAT>C,NM_006005.3:c.233-28_233-27del,\N,\N,2/7,Unknown significance,\N,intron_variant,8.932,\N,\N,WFS1
613930,4:6288800:T>G,NM_006005.3:c.233-20T>G,\N,\N,2/7,Unknown significance,\N,intron_variant,6.864,\N,\N,WFS1
613931,4:6288858:G>A,NM_006005.3:c.271G>A,NP_005996.2:p.Val91Ile,3/8,\N,Likely benign,\N,missense_variant,0.02,0.000503626,EXAC_NFE_AF,WFS1
613932,4:6288862:T>C,NM_006005.3:c.275T>C,NP_005996.2:p.Leu92Pro,3/8,\N,Unknown significance,\N,missense_variant,23.1,0.000117509,EVS_EA_AF,WFS1
613933,4:6288863:G>A,NM_006005.3:c.276G>A,NP_005996.2:p.Leu92=,3/8,\N,Unknown significance,\N,synonymous_variant,6.066,0.000323625,EXAC_AFR_AF,WFS1
613934,4:6288874:A>C,NM_006005.3:c.287A>C,NP_005996.2:p.Lys96Thr,3/8,\N,Unknown significance,\N,missense_variant,23.1,\N,\N,WFS1
613935,4:6288878:C>T,NM_006005.3:c.291C>T,NP_005996.2:p.Ala97=,3/8,\N,Unknown significance,\N,synonymous_variant,14.06,0.000619272,EXAC_SAS_AF,WFS1
613936,4:6288881:G>A,NM_006005.3:c.294G>A,NP_005996.2:p.Gly98=,3/8,\N,Unknown significance,\N,synonymous_variant,7.495,0.002,1KG_SAS_AF,WFS1
613937,4:6288881:G>C,NM_006005.3:c.294G>C,NP_005996.2:p.Gly98=,3/8,\N,Unknown significance,\N,synonymous_variant,3.624,0.0000993049,EXAC_NFE_AF,WFS1
613938,4:6288894:C>T,NM_006005.3:c.307C>T,NP_005996.2:p.Gln103Ter,3/8,\N,Pathogenic,Wolfram syndrome,stop_gained,37,\N,\N,WFS1
613939,4:6288909:A>G,NM_006005.3:c.315+7A>G,\N,\N,3/7,Unknown significance,\N,splice_region_variant&intron_variant,7.039,0.000103157,EXAC_NFE_AF,WFS1
613940,4:6288913:C>T,NM_006005.3:c.315+11C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,6.023,0.0046729,EXAC_AMR_AF,WFS1
613941,4:6288914:G>A,NM_006005.3:c.315+12G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,0.664,0.000340599,EXAC_AFR_AF,WFS1
613942,4:6288919:C>T,NM_006005.3:c.315+17C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,1.14,\N,\N,WFS1
613943,4:6288920:G>A,NM_006005.3:c.315+18G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,1.405,0.003,1KG_EAS_AF,WFS1
613944,4:6288931:C>G,NM_006005.3:c.315+29C>G,\N,\N,3/7,Unknown significance,\N,intron_variant,3.354,0.000762195,EXAC_AFR_AF,WFS1
613945,4:6288931:C>T,NM_006005.3:c.315+29C>T,\N,\N,3/7,Benign,\N,intron_variant,5.136,0.0123,1KG_SAS_AF,WFS1
613946,4:6288932:G>A,NM_006005.3:c.315+30G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,2.931,0.000483092,EVS_AA_AF,WFS1
613947,4:6288936:C>T,NM_006005.3:c.315+34C>T,\N,\N,3/7,Benign,\N,intron_variant,4.269,0.00985222,EXAC_AFR_AF,WFS1
613948,4:6288938:C>T,NM_006005.3:c.315+36C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,3.745,\N,\N,WFS1
613949,4:6288939:G>A,NM_006005.3:c.315+37G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,0.104,0.00165017,EXAC_EAS_AF,WFS1
613950,4:6288946:G>A,NM_006005.3:c.315+44G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,4.029,0.001,1KG_EUR_AF,WFS1
613951,4:6288947:G>T,NM_006005.3:c.315+45G>T,\N,\N,3/7,Unknown significance,\N,intron_variant,3.891,0.001,1KG_EAS_AF,WFS1
613952,4:6288953:C>G,NM_006005.3:c.315+51C>G,\N,\N,3/7,Unknown significance,\N,intron_variant,2.291,0.000127194,EXAC_SAS_AF,WFS1
613953,4:6288954:A>G,NM_006005.3:c.315+52A>G,\N,\N,3/7,Unknown significance,\N,intron_variant,0.985,\N,\N,WFS1
613954,4:6288965:C>T,NM_006005.3:c.315+63C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,1.089,\N,\N,WFS1
613955,4:6288966:G>A,NM_006005.3:c.315+64G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,1.794,0.0014,1KG_AMR_AF,WFS1
613956,4:6288981:C>T,NM_006005.3:c.315+79C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,4.593,0.0008,1KG_AFR_AF,WFS1
613957,4:6289006:G>A,NM_006005.3:c.315+104G>A,\N,\N,3/7,Benign,\N,intron_variant,1.187,0.0099,1KG_EUR_AF,WFS1
613958,4:6289037:C>G,NM_006005.3:c.315+135C>G,\N,\N,3/7,Unknown significance,\N,intron_variant,2.337,0.0038,1KG_AFR_AF,WFS1
613959,4:6289056:G>A,NM_006005.3:c.315+154G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,5.306,\N,\N,WFS1
613960,4:6289078:G>T,NM_006005.3:c.315+176G>T,\N,\N,3/7,Benign,\N,intron_variant,1.51,0.0151,1KG_AFR_AF,WFS1
613961,4:6289094:G>A,NM_006005.3:c.315+192G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,3.832,\N,\N,WFS1
613962,4:6289101:T>C,NM_006005.3:c.315+199T>C,\N,\N,3/7,Unknown significance,\N,intron_variant,2.896,0.001,1KG_EUR_AF,WFS1
613963,4:6289117:C>T,NM_006005.3:c.315+215C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,3.4,0.001,1KG_EAS_AF,WFS1
613964,4:6289138:A>T,NM_006005.3:c.315+236A>T,\N,\N,3/7,Benign,\N,intron_variant,3.842,0.0257,1KG_AFR_AF,WFS1
613965,4:6289150:G>C,NM_006005.3:c.315+248G>C,\N,\N,3/7,Unknown significance,\N,intron_variant,1.696,0.003,1KG_AFR_AF,WFS1
613966,4:6289167:G>C,NM_006005.3:c.315+265G>C,\N,\N,3/7,Unknown significance,\N,intron_variant,1.277,\N,\N,WFS1
613967,4:6289194:C>T,NM_006005.3:c.315+292C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,5.233,0.0008,1KG_AFR_AF,WFS1
613968,4:6289201:A>C,NM_006005.3:c.315+299A>C,\N,\N,3/7,Unknown significance,\N,intron_variant,0.013,\N,\N,WFS1
613969,4:6289238:C>T,NM_006005.3:c.315+336C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,2.467,\N,\N,WFS1
613970,4:6289273:TA>T,NM_006005.3:c.315+372del,\N,\N,3/7,Unknown significance,\N,intron_variant,6.406,\N,\N,WFS1
613971,4:6289275:G>GCTGTGTGC,NM_006005.3:c.315+374_315+381dup,\N,\N,3/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613972,4:6289299:C>T,NM_006005.3:c.315+397C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,6.671,\N,\N,WFS1
613973,4:6289300:G>A,NM_006005.3:c.315+398G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,1.997,0.001,1KG_EAS_AF,WFS1
613974,4:6289308:T>A,NM_006005.3:c.315+406T>A,\N,\N,3/7,Unknown significance,\N,intron_variant,5.78,\N,\N,WFS1
613975,4:6289324:C>G,NM_006005.3:c.315+422C>G,\N,\N,3/7,Unknown significance,\N,intron_variant,4.352,0.001,1KG_SAS_AF,WFS1
613976,4:6289368:C>T,NM_006005.3:c.315+466C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,0.865,0.0008,1KG_AFR_AF,WFS1
613977,4:6289370:C>T,NM_006005.3:c.315+468C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,0.552,0.002,1KG_EAS_AF,WFS1
613978,4:6289372:C>A,NM_006005.3:c.315+470C>A,\N,\N,3/7,Unknown significance,\N,intron_variant,5.004,\N,\N,WFS1
613979,4:6289373:T>C,NM_006005.3:c.315+471T>C,\N,\N,3/7,Unknown significance,\N,intron_variant,1.305,0.001,1KG_SAS_AF,WFS1
613980,4:6289426:A>C,NM_006005.3:c.315+524A>C,\N,\N,3/7,Unknown significance,\N,intron_variant,1.054,\N,\N,WFS1
613981,4:6289474:C>T,NM_006005.3:c.315+572C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,3.905,\N,\N,WFS1
613982,4:6289479:C>T,NM_006005.3:c.315+577C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,0.01,0.001,1KG_SAS_AF,WFS1
613983,4:6289480:G>A,NM_006005.3:c.315+578G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,1.368,0.004,1KG_EAS_AF,WFS1
613984,4:6289487:C>T,NM_006005.3:c.315+585C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,1.421,0.001,1KG_SAS_AF,WFS1
613985,4:6289488:G>A,NM_006005.3:c.315+586G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,0.085,\N,\N,WFS1
613986,4:6289512:C>T,NM_006005.3:c.315+610C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,5.221,\N,\N,WFS1
613987,4:6289530:C>T,NM_006005.3:c.315+628C>T,\N,\N,3/7,Benign,\N,intron_variant,4.499,0.0092,1KG_SAS_AF,WFS1
613988,4:6289532:C>T,NM_006005.3:c.315+630C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,0.906,0.0023,1KG_AFR_AF,WFS1
613989,4:6289566:A>G,NM_006005.3:c.315+664A>G,\N,\N,3/7,Unknown significance,\N,intron_variant,3.905,0.001,1KG_SAS_AF,WFS1
613990,4:6289606:T>C,NM_006005.3:c.315+704T>C,\N,\N,3/7,Benign,\N,intron_variant,0.119,0.0123,1KG_SAS_AF,WFS1
613991,4:6289637:G>A,NM_006005.3:c.315+735G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,2.04,0.001,1KG_SAS_AF,WFS1
613992,4:6289656:A>AT,NM_006005.3:c.315+757dup,\N,\N,3/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613993,4:6289665:T>TG,NM_006005.3:c.315+766dup,\N,\N,3/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
613994,4:6289671:C>T,NM_006005.3:c.315+769C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,0.242,0.001,1KG_SAS_AF,WFS1
613995,4:6289672:G>A,NM_006005.3:c.315+770G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,0.585,\N,\N,WFS1
613996,4:6289693:C>T,NM_006005.3:c.315+791C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,1.367,0.0008,1KG_AFR_AF,WFS1
613997,4:6289697:A>G,NM_006005.3:c.315+795A>G,\N,\N,3/7,Unknown significance,\N,intron_variant,2.014,\N,\N,WFS1
613998,4:6289714:C>T,NM_006005.3:c.315+812C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,1.189,0.001,1KG_SAS_AF,WFS1
613999,4:6289715:G>A,NM_006005.3:c.315+813G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,0.104,\N,\N,WFS1
614000,4:6289736:G>C,NM_006005.3:c.315+834G>C,\N,\N,3/7,Benign,\N,intron_variant,2.078,0.0092,1KG_SAS_AF,WFS1
614001,4:6289742:G>A,NM_006005.3:c.315+840G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,1.876,0.0008,1KG_AFR_AF,WFS1
614002,4:6289751:C>T,NM_006005.3:c.315+849C>T,\N,\N,3/7,Benign,\N,intron_variant,5.373,0.0514,1KG_AFR_AF,WFS1
614003,4:6289771:G>A,NM_006005.3:c.315+869G>A,\N,\N,3/7,Benign,\N,intron_variant,0.459,0.0151,1KG_AFR_AF,WFS1
614004,4:6289775:C>T,NM_006005.3:c.315+873C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,2.838,0.0008,1KG_AFR_AF,WFS1
614005,4:6289790:A>G,NM_006005.3:c.315+888A>G,\N,\N,3/7,Unknown significance,\N,intron_variant,1.023,0.001,1KG_EAS_AF,WFS1
614006,4:6289830:G>A,NM_006005.3:c.316-884G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,2.496,\N,\N,WFS1
614007,4:6289835:T>C,NM_006005.3:c.316-879T>C,\N,\N,3/7,Unknown significance,\N,intron_variant,1.568,0.003,1KG_EUR_AF,WFS1
614008,4:6289883:G>A,NM_006005.3:c.316-831G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,2.645,0.003,1KG_EAS_AF,WFS1
614009,4:6289900:C>T,NM_006005.3:c.316-814C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,2.184,\N,\N,WFS1
614010,4:6289909:G>A,NM_006005.3:c.316-805G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,0.122,0.0008,1KG_AFR_AF,WFS1
614011,4:6289926:A>G,NM_006005.3:c.316-788A>G,\N,\N,3/7,Benign,\N,intron_variant,1.04,0.0061,1KG_AFR_AF,WFS1
614012,4:6289943:C>CA,NM_006005.3:c.316-752dup,\N,\N,3/7,Benign,\N,intron_variant,2.15,0.5102,1KG_SAS_AF,WFS1
614013,4:6289943:C>CAA,NM_006005.3:c.316-753_316-752dup,\N,\N,3/7,Unknown significance,\N,intron_variant,2.014,\N,\N,WFS1
614014,4:6289945:A>C,NM_006005.3:c.316-769A>C,\N,\N,3/7,Unknown significance,\N,intron_variant,0.764,\N,\N,WFS1
614015,4:6289971:C>G,NM_006005.3:c.316-743C>G,\N,\N,3/7,Unknown significance,\N,intron_variant,0.671,0.003,1KG_AFR_AF,WFS1
614016,4:6289984:C>T,NM_006005.3:c.316-730C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,1.282,\N,\N,WFS1
614017,4:6289986:T>G,NM_006005.3:c.316-728T>G,\N,\N,3/7,Benign,\N,intron_variant,1.276,0.9038,1KG_EAS_AF,WFS1
614018,4:6290011:A>C,NM_006005.3:c.316-703A>C,\N,\N,3/7,Unknown significance,\N,intron_variant,0.816,0.001,1KG_EUR_AF,WFS1
614019,4:6290013:C>G,NM_006005.3:c.316-701C>G,\N,\N,3/7,Unknown significance,\N,intron_variant,2.763,\N,\N,WFS1
614020,4:6290019:G>C,NM_006005.3:c.316-695G>C,\N,\N,3/7,Benign,\N,intron_variant,0.431,0.0189,1KG_AFR_AF,WFS1
614021,4:6290024:G>T,NM_006005.3:c.316-690G>T,\N,\N,3/7,Unknown significance,\N,intron_variant,5.575,\N,\N,WFS1
614022,4:6290037:G>C,NM_006005.3:c.316-677G>C,\N,\N,3/7,Benign,\N,intron_variant,0.05,0.9077,1KG_EAS_AF,WFS1
614023,4:6290040:G>A,NM_006005.3:c.316-674G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,1.523,0.001,1KG_EAS_AF,WFS1
614024,4:6290046:A>T,NM_006005.3:c.316-668A>T,\N,\N,3/7,Unknown significance,\N,intron_variant,0.194,0.001,1KG_SAS_AF,WFS1
614025,4:6290053:G>A,NM_006005.3:c.316-661G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,3.677,0.001,1KG_EUR_AF,WFS1
614026,4:6290063:G>A,NM_006005.3:c.316-651G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,2.118,0.0008,1KG_AFR_AF,WFS1
614027,4:6290066:C>A,NM_006005.3:c.316-648C>A,\N,\N,3/7,Unknown significance,\N,intron_variant,2.75,0.001,1KG_SAS_AF,WFS1
614028,4:6290068:C>G,NM_006005.3:c.316-646C>G,\N,\N,3/7,Benign,\N,intron_variant,0.983,0.0098,1KG_AFR_AF,WFS1
614029,4:6290073:T>G,NM_006005.3:c.316-641T>G,\N,\N,3/7,Unknown significance,\N,intron_variant,3.318,0.0014,1KG_AMR_AF,WFS1
614030,4:6290076:C>A,NM_006005.3:c.316-638C>A,\N,\N,3/7,Unknown significance,\N,intron_variant,3.087,0.0015,1KG_AFR_AF,WFS1
614031,4:6290078:T>A,NM_006005.3:c.316-636T>A,\N,\N,3/7,Unknown significance,\N,intron_variant,6.904,\N,\N,WFS1
614032,4:6290079:G>A,NM_006005.3:c.316-635G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,5.564,\N,\N,WFS1
614033,4:6290081:G>T,NM_006005.3:c.316-633G>T,\N,\N,3/7,Unknown significance,\N,intron_variant,4.659,\N,\N,WFS1
614034,4:6290085:C>G,NM_006005.3:c.316-629C>G,\N,\N,3/7,Unknown significance,\N,intron_variant,5.95,\N,\N,WFS1
614035,4:6290102:G>A,NM_006005.3:c.316-612G>A,\N,\N,3/7,Benign,\N,intron_variant,1.738,0.0151,1KG_AFR_AF,WFS1
614036,4:6290144:A>C,NM_006005.3:c.316-570A>C,\N,\N,3/7,Unknown significance,\N,intron_variant,5.516,\N,\N,WFS1
614037,4:6290151:A>G,NM_006005.3:c.316-563A>G,\N,\N,3/7,Unknown significance,\N,intron_variant,2.862,\N,\N,WFS1
614038,4:6290173:T>C,NM_006005.3:c.316-541T>C,\N,\N,3/7,Unknown significance,\N,intron_variant,0.462,0.001,1KG_SAS_AF,WFS1
614039,4:6290175:C>T,NM_006005.3:c.316-539C>T,\N,\N,3/7,Benign,\N,intron_variant,0.419,0.0051,1KG_SAS_AF,WFS1
614040,4:6290188:G>A,NM_006005.3:c.316-526G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,4.121,\N,\N,WFS1
614041,4:6290190:G>A,NM_006005.3:c.316-524G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,4.08,0.001,1KG_EUR_AF,WFS1
614042,4:6290218:A>C,NM_006005.3:c.316-496A>C,\N,\N,3/7,Unknown significance,\N,intron_variant,2.283,\N,\N,WFS1
614043,4:6290293:T>C,NM_006005.3:c.316-421T>C,\N,\N,3/7,Unknown significance,\N,intron_variant,0.146,\N,\N,WFS1
614044,4:6290315:T>G,NM_006005.3:c.316-399T>G,\N,\N,3/7,Unknown significance,\N,intron_variant,5.582,0.003125,OTO_CO_AF,WFS1
614045,4:6290323:G>A,NM_006005.3:c.316-391G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,4.734,\N,\N,WFS1
614046,4:6290328:T>G,NM_006005.3:c.316-386T>G,\N,\N,3/7,Benign,\N,intron_variant,7.827,0.005,1KG_EAS_AF|OTO_JP_AF,WFS1
614047,4:6290351:C>A,NM_006005.3:c.316-363C>A,\N,\N,3/7,Unknown significance,\N,intron_variant,8.123,0.0014,1KG_AMR_AF,WFS1
614048,4:6290353:C>G,NM_006005.3:c.316-361C>G,\N,\N,3/7,Unknown significance,\N,intron_variant,6.752,0.0008,1KG_AFR_AF,WFS1
614049,4:6290357:C>T,NM_006005.3:c.316-357C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,7.971,0.00277778,OTO_ES_AF,WFS1
614050,4:6290419:T>C,NM_006005.3:c.316-295T>C,\N,\N,3/7,Unknown significance,\N,intron_variant,2.949,\N,\N,WFS1
614051,4:6290425:G>A,NM_006005.3:c.316-289G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,6.12,\N,\N,WFS1
614052,4:6290432:G>A,NM_006005.3:c.316-282G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,3.551,0.0045,1KG_AFR_AF,WFS1
614053,4:6290433:C>G,NM_006005.3:c.316-281C>G,\N,\N,3/7,Unknown significance,\N,intron_variant,4.363,0.001,1KG_SAS_AF,WFS1
614054,4:6290438:C>A,NM_006005.3:c.316-276C>A,\N,\N,3/7,Unknown significance,\N,intron_variant,3.022,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614055,4:6290457:C>T,NM_006005.3:c.316-257C>T,\N,\N,3/7,Benign,\N,intron_variant,3.543,0.00625,OTO_US_AF,WFS1
614056,4:6290468:G>A,NM_006005.3:c.316-246G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,4.011,\N,\N,WFS1
614057,4:6290473:C>T,NM_006005.3:c.316-241C>T,\N,\N,3/7,Benign,\N,intron_variant,6.136,0.0079,1KG_EAS_AF,WFS1
614058,4:6290474:C>T,NM_006005.3:c.316-240C>T,\N,\N,3/7,Benign,\N,intron_variant,2.273,0.0159,1KG_AFR_AF,WFS1
614059,4:6290479:C>G,NM_006005.3:c.316-235C>G,\N,\N,3/7,Benign,\N,intron_variant,2.783,0.115,OTO_AJ_AF,WFS1
614060,4:6290486:G>A,NM_006005.3:c.316-228G>A,\N,\N,3/7,Benign,\N,intron_variant,0.333,0.0091,1KG_AFR_AF,WFS1
614061,4:6290489:G>A,NM_006005.3:c.316-225G>A,\N,\N,3/7,Benign,\N,intron_variant,0.382,0.059,1KG_AFR_AF,WFS1
614062,4:6290500:G>A,NM_006005.3:c.316-214G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,7.618,\N,\N,WFS1
614063,4:6290501:T>G,NM_006005.3:c.316-213T>G,\N,\N,3/7,Unknown significance,\N,intron_variant,9.372,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614064,4:6290504:C>T,NM_006005.3:c.316-210C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,8.981,0.001,1KG_SAS_AF,WFS1
614065,4:6290508:A>C,NM_006005.3:c.316-206A>C,\N,\N,3/7,Unknown significance,\N,intron_variant,1.396,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614066,4:6290510:C>CT,NM_006005.3:c.316-202dup,\N,\N,3/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614067,4:6290519:C>T,NM_006005.3:c.316-195C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,1.089,\N,\N,WFS1
614068,4:6290520:G>A,NM_006005.3:c.316-194G>A,\N,\N,3/7,Benign,\N,intron_variant,0.092,0.0461,1KG_AFR_AF,WFS1
614069,4:6290533:C>T,NM_006005.3:c.316-181C>T,\N,\N,3/7,Unknown significance,\N,intron_variant,1.987,\N,\N,WFS1
614070,4:6290534:G>A,NM_006005.3:c.316-180G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,1.549,0.001,1KG_EUR_AF,WFS1
614071,4:6290537:T>G,NM_006005.3:c.316-177T>G,\N,\N,3/7,Unknown significance,\N,intron_variant,4.754,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614072,4:6290543:G>C,NM_006005.3:c.316-171G>C,\N,\N,3/7,Unknown significance,\N,intron_variant,5.184,0.0008,1KG_AFR_AF,WFS1
614073,4:6290550:A>G,NM_006005.3:c.316-164A>G,\N,\N,3/7,Benign,\N,intron_variant,8.138,0.1157,1KG_AFR_AF,WFS1
614074,4:6290556:G>T,NM_006005.3:c.316-158G>T,\N,\N,3/7,Unknown significance,\N,intron_variant,6.829,0.0038,1KG_AFR_AF,WFS1
614075,4:6290566:G>A,NM_006005.3:c.316-148G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,2.102,\N,\N,WFS1
614076,4:6290588:C>A,NM_006005.3:c.316-126C>A,\N,\N,3/7,Unknown significance,\N,intron_variant,5.094,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614077,4:6290594:T>C,NM_006005.3:c.316-120T>C,\N,\N,3/7,Benign,\N,intron_variant,1.321,0.9077,1KG_EAS_AF,WFS1
614078,4:6290628:A>G,NM_006005.3:c.316-86A>G,\N,\N,3/7,Unknown significance,\N,intron_variant,6.894,0.0014,1KG_AMR_AF,WFS1
614079,4:6290634:T>G,NM_006005.3:c.316-80T>G,\N,\N,3/7,Unknown significance,\N,intron_variant,12.06,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614080,4:6290644:T>G,NM_006005.3:c.316-70T>G,\N,\N,3/7,Unknown significance,\N,intron_variant,11.76,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614081,4:6290653:A>G,NM_006005.3:c.316-61A>G,\N,\N,3/7,Unknown significance,\N,intron_variant,3.561,0.0008,1KG_AFR_AF,WFS1
614082,4:6290663:G>T,NM_006005.3:c.316-51G>T,\N,\N,3/7,Unknown significance,\N,intron_variant,3.284,0.000153092,EXAC_AMR_AF,WFS1
614083,4:6290666:T>G,NM_006005.3:c.316-48T>G,\N,\N,3/7,Unknown significance,\N,intron_variant,5.74,0.003125,OTO_US_AF,WFS1
614084,4:6290674:G>C,NM_006005.3:c.316-40G>C,\N,\N,3/7,Unknown significance,\N,intron_variant,4.164,0.000116306,EVS_EA_AF,WFS1
614085,4:6290676:T>G,NM_006005.3:c.316-38T>G,\N,\N,3/7,Unknown significance,\N,intron_variant,4.682,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614086,4:6290677:C>A,NM_006005.3:c.316-37C>A,\N,\N,3/7,Unknown significance,\N,intron_variant,6.106,\N,\N,WFS1
614087,4:6290677:C>T,NM_006005.3:c.316-37C>T,\N,\N,3/7,Benign,\N,intron_variant,6.183,0.0148783,EXAC_SAS_AF,WFS1
614088,4:6290678:G>A,NM_006005.3:c.316-36G>A,\N,\N,3/7,Unknown significance,\N,intron_variant,2.637,0.002,1KG_EUR_AF,WFS1
614089,4:6290681:G>C,NM_006005.3:c.316-33G>C,\N,\N,3/7,Unknown significance,\N,intron_variant,2.18,0.000116306,EVS_EA_AF,WFS1
614090,4:6290686:T>C,NM_006005.3:c.316-28T>C,\N,\N,3/7,Unknown significance,\N,intron_variant,6.586,0.0000226224,EXAC_NFE_AF,WFS1
614091,4:6290690:G>T,NM_006005.3:c.316-24G>T,\N,\N,3/7,Unknown significance,\N,intron_variant,6.366,0.000227376,EVS_AA_AF,WFS1
614092,4:6290691:G>C,NM_006005.3:c.316-23G>C,\N,\N,3/7,Unknown significance,\N,intron_variant,3.091,0.0000225561,EXAC_NFE_AF,WFS1
614093,4:6290699:G>C,NM_006005.3:c.316-15G>C,\N,\N,3/7,Unknown significance,\N,intron_variant,0.322,\N,\N,WFS1
614094,4:6290700:T>G,NM_006005.3:c.316-14T>G,\N,\N,3/7,Unknown significance,\N,intron_variant,0.127,0.0000449035,EXAC_NFE_AF,WFS1
614095,4:6290707:C>A,NM_006005.3:c.316-7C>A,\N,\N,3/7,Unknown significance,\N,splice_region_variant&intron_variant,5.815,0.000163452,EXAC_EAS_AF,WFS1
614096,4:6290707:C>G,NM_006005.3:c.316-7C>G,\N,\N,3/7,Unknown significance,\N,splice_region_variant&intron_variant,3.294,0.0000865651,EXAC_SAS_AF,WFS1
614097,4:6290709:T>G,NM_006005.3:c.316-5T>G,\N,\N,3/7,Unknown significance,\N,splice_region_variant&intron_variant,6.866,0.000172921,EXAC_SAS_AF,WFS1
614098,4:6290715:T>TG,NM_006005.3:c.321dup,NP_005996.2:p.Lys108GlufsTer12,4/8,\N,Unknown significance,\N,frameshift_variant&splice_region_variant,\N,\N,\N,WFS1
614099,4:6290715:T>G,NM_006005.3:c.317T>G,NP_005996.2:p.Val106Gly,4/8,\N,Benign,\N,missense_variant&splice_region_variant,24.5,0.005,OTO_TR_AF,WFS1
614100,4:6290716:G>A,NM_006005.3:c.318G>A,NP_005996.2:p.Val106=,4/8,\N,Unknown significance,\N,splice_region_variant&synonymous_variant,14.16,0.0000864454,EXAC_SAS_AF,WFS1
614101,4:6290717:G>C,NM_006005.3:c.319G>C,NP_005996.2:p.Gly107Arg,4/8,\N,Pathogenic,Wolfram syndrome,missense_variant,26,\N,\N,WFS1
614102,4:6290718:G>A,NM_006005.3:c.320G>A,NP_005996.2:p.Gly107Glu,4/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.7,\N,\N,WFS1
614103,4:6290723:C>T,NM_006005.3:c.325C>T,NP_005996.2:p.His109Tyr,4/8,\N,Unknown significance,\N,missense_variant,12.58,0.0015,1KG_AFR_AF,WFS1
614104,4:6290724:A>G,NM_006005.3:c.326A>G,NP_005996.2:p.His109Arg,4/8,\N,Unknown significance,\N,missense_variant,11.16,0.0000221729,EXAC_NFE_AF,WFS1
614105,4:6290726:T>A,NM_006005.3:c.328T>A,NP_005996.2:p.Tyr110Asn,4/8,\N,Pathogenic,Wolfram syndrome,missense_variant,27.7,\N,\N,WFS1
614106,4:6290731:G>A,NM_006005.3:c.333G>A,NP_005996.2:p.Leu111=,4/8,\N,Unknown significance,\N,synonymous_variant,7.811,0.001,1KG_SAS_AF,WFS1
614107,4:6290740:C>T,NM_006005.3:c.342C>T,NP_005996.2:p.Ala114=,4/8,\N,Benign,\N,synonymous_variant,13.21,0.005,EXAC_AMR_AF,WFS1
614108,4:6290741:G>A,NM_006005.3:c.343G>A,NP_005996.2:p.Gly115Ser,4/8,\N,Likely benign,\N,missense_variant,0.007,0.000166945,EXAC_EAS_AF,WFS1
614109,4:6290743:C>T,NM_006005.3:c.345C>T,NP_005996.2:p.Gly115=,4/8,\N,Unknown significance,\N,synonymous_variant,12.37,0.001,1KG_EAS_AF,WFS1
614110,4:6290747:A>G,NM_006005.3:c.349A>G,NP_005996.2:p.Thr117Ala,4/8,\N,Likely benign,\N,missense_variant,0.002,0.0000884799,EXAC_SAS_AF,WFS1
614111,4:6290748:C>T,NM_006005.3:c.350C>T,NP_005996.2:p.Thr117Met,4/8,\N,Benign,\N,missense_variant,7.707,0.0102071,EXAC_AFR_AF,WFS1
614112,4:6290748:C>G,NM_006005.3:c.350C>G,NP_005996.2:p.Thr117Arg,4/8,\N,Likely benign,\N,missense_variant,0.098,0.0003663,EXAC_FIN_AF,WFS1
614113,4:6290749:G>A,NM_006005.3:c.351G>A,NP_005996.2:p.Thr117=,4/8,\N,Unknown significance,\N,synonymous_variant,8.172,\N,\N,WFS1
614114,4:6290749:G>T,NM_006005.3:c.351G>T,NP_005996.2:p.Thr117=,4/8,\N,Unknown significance,\N,synonymous_variant,2.232,0.0000235438,EXAC_NFE_AF,WFS1
614115,4:6290751:A>C,NM_006005.3:c.353A>C,NP_005996.2:p.Asp118Ala,4/8,\N,Benign,\N,missense_variant,24.5,0.0121,1KG_AFR_AF,WFS1
614116,4:6290754:A>C,NM_006005.3:c.356A>C,NP_005996.2:p.Glu119Ala,4/8,\N,Unknown significance,\N,missense_variant,22.7,0.0000890789,EXAC_SAS_AF,WFS1
614117,4:6290761:C>T,NM_006005.3:c.363C>T,NP_005996.2:p.Leu121=,4/8,\N,Unknown significance,\N,synonymous_variant,9.458,0.00295214,EXAC_AFR_AF,WFS1
614118,4:6290770:C>A,NM_006005.3:c.372C>A,NP_005996.2:p.Cys124Ter,4/8,\N,Unknown significance,\N,stop_gained,34,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614119,4:6290771:A>C,NM_006005.3:c.373A>C,NP_005996.2:p.Thr125Pro,4/8,\N,Unknown significance,\N,missense_variant,18.42,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614120,4:6290773:C>A,NM_006005.3:c.375C>A,NP_005996.2:p.Thr125=,4/8,\N,Unknown significance,\N,synonymous_variant,13.71,0.000193874,EXAC_EAS_AF,WFS1
614121,4:6290773:C>T,NM_006005.3:c.375C>T,NP_005996.2:p.Thr125=,4/8,\N,Unknown significance,\N,synonymous_variant,9.889,0.000387747,EXAC_EAS_AF,WFS1
614122,4:6290774:G>A,NM_006005.3:c.376G>A,NP_005996.2:p.Ala126Thr,4/8,\N,Pathogenic,Wolfram syndrome,missense_variant,26.7,0.000348837,EVS_EA_AF,WFS1
614123,4:6290780:G>T,NM_006005.3:c.382G>T,NP_005996.2:p.Asp128Tyr,4/8,\N,Unknown significance,\N,missense_variant,14.49,0.0000286779,EXAC_NFE_AF,WFS1
614124,4:6290785:G>A,NM_006005.3:c.387G>A,NP_005996.2:p.Trp129Ter,4/8,\N,Pathogenic,Wolfram syndrome,stop_gained,36,0.0000317058,EXAC_NFE_AF,WFS1
614125,4:6290790:T>G,NM_006005.3:c.392T>G,NP_005996.2:p.Val131Gly,4/8,\N,Benign,\N,missense_variant,14.99,0.128125,OTO_US_AF,WFS1
614126,4:6290791:C>T,NM_006005.3:c.393C>T,NP_005996.2:p.Val131=,4/8,\N,Unknown significance,\N,synonymous_variant,11.4,0.000205002,EXAC_AFR_AF,WFS1
614127,4:6290793:T>G,NM_006005.3:c.395T>G,NP_005996.2:p.Leu132Arg,4/8,\N,Unknown significance,\N,missense_variant,0.654,\N,\N,WFS1
614128,4:6290794:C>T,NM_006005.3:c.396C>T,NP_005996.2:p.Leu132=,4/8,\N,Unknown significance,\N,synonymous_variant,9.559,0.000454959,EVS_AA_AF,WFS1
614129,4:6290795:G>A,NM_006005.3:c.397G>A,NP_005996.2:p.Ala133Thr,4/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.7,0.000116387,EVS_EA_AF,WFS1
614130,4:6290797:C>T,NM_006005.3:c.399C>T,NP_005996.2:p.Ala133=,4/8,\N,Unknown significance,\N,synonymous_variant,14,0.0000381214,EXAC_NFE_AF,WFS1
614131,4:6290798:G>A,NM_006005.3:c.400G>A,NP_005996.2:p.Ala134Thr,4/8,\N,Unknown significance,\N,missense_variant,26.1,0.000395351,EXAC_NFE_AF,WFS1
614132,4:6290799:C>T,NM_006005.3:c.401C>T,NP_005996.2:p.Ala134Val,4/8,\N,Unknown significance,\N,missense_variant,22.4,0.0000392989,EXAC_NFE_AF,WFS1
614133,4:6290800:G>A,NM_006005.3:c.402G>A,NP_005996.2:p.Ala134=,4/8,\N,Benign,\N,synonymous_variant,5.584,0.0241148,EXAC_EAS_AF,WFS1
614134,4:6290802:A>G,NM_006005.3:c.404A>G,NP_005996.2:p.Lys135Arg,4/8,\N,Unknown significance,\N,missense_variant,25,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614135,4:6290804:C>T,NM_006005.3:c.406C>T,NP_005996.2:p.Gln136Ter,4/8,\N,Pathogenic,Wolfram syndrome,stop_gained,35,\N,\N,WFS1
614136,4:6290805:A>AGGGCCGTCGCGAGGCT,NM_006005.3:c.409_424dup,NP_005996.2:p.Val142GlyfsTer110,4/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,26.4,0.0000414766,EXAC_NFE_AF,WFS1
614137,4:6290805:A>T,NM_006005.3:c.407A>T,NP_005996.2:p.Gln136Leu,4/8,\N,Unknown significance,\N,missense_variant,25.1,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614138,4:6290810:C>T,NM_006005.3:c.412C>T,NP_005996.2:p.Arg138Cys,4/8,\N,Unknown significance,\N,missense_variant,33,0.0000446987,EXAC_NFE_AF,WFS1
614139,4:6290811:G>A,NM_006005.3:c.413G>A,NP_005996.2:p.Arg138His,4/8,\N,Unknown significance,\N,missense_variant,32,0.000109987,EXAC_SAS_AF,WFS1
614140,4:6290814:G>A,NM_006005.3:c.416G>A,NP_005996.2:p.Arg139His,4/8,\N,Unknown significance,\N,missense_variant,25.6,0.000465549,EVS_EA_AF,WFS1
614141,4:6290815:C>G,NM_006005.3:c.417C>G,NP_005996.2:p.Arg139=,4/8,\N,Unknown significance,\N,synonymous_variant,15.94,0.000379939,EXAC_EAS_AF,WFS1
614142,4:6290815:C>T,NM_006005.3:c.417C>T,NP_005996.2:p.Arg139=,4/8,\N,Unknown significance,\N,synonymous_variant,19.06,0.000856898,EXAC_AMR_AF,WFS1
614143,4:6290822:G>T,NM_006005.3:c.424G>T,NP_005996.2:p.Val142Leu,4/8,\N,Unknown significance,\N,missense_variant,22.1,0.000116387,EVS_EA_AF,WFS1
614144,4:6290830:G>A,NM_006005.3:c.432G>A,NP_005996.2:p.Leu144=,4/8,\N,Unknown significance,\N,synonymous_variant,10.57,\N,\N,WFS1
614145,4:6290835:G>A,NM_006005.3:c.437G>A,NP_005996.2:p.Arg146His,4/8,\N,Unknown significance,\N,missense_variant,33,0.000116442,EVS_EA_AF,WFS1
614146,4:6290835:G>T,NM_006005.3:c.437G>T,NP_005996.2:p.Arg146Leu,4/8,\N,Unknown significance,\N,missense_variant,23.6,\N,\N,WFS1
614147,4:6290835:GC>G,NM_006005.3:c.439del,NP_005996.2:p.Arg147GlyfsTer17,4/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,27.5,\N,\N,WFS1
614148,4:6290837:C>T,NM_006005.3:c.439C>T,NP_005996.2:p.Arg147Trp,4/8,\N,Unknown significance,\N,missense_variant,34,0.0000558971,EXAC_NFE_AF,WFS1
614149,4:6290847:C>T,NM_006005.3:c.449C>T,NP_005996.2:p.Ala150Val,4/8,\N,Benign,\N,missense_variant,26.3,0.01,OTO_JP_AF,WFS1
614150,4:6290848:G>A,NM_006005.3:c.450G>A,NP_005996.2:p.Ala150=,4/8,\N,Unknown significance,\N,synonymous_variant,14.48,0.000617284,EXAC_AMR_AF,WFS1
614151,4:6290852:A>G,NM_006005.3:c.454A>G,NP_005996.2:p.Arg152Gly,4/8,\N,Unknown significance,\N,missense_variant,23.5,0.001,1KG_EUR_AF,WFS1
614152,4:6290859:G>A,NM_006005.3:c.460+1G>A,\N,\N,4/7,Pathogenic,Wolfram syndrome,splice_donor_variant,23.4,\N,\N,WFS1
614153,4:6290860:T>G,NM_006005.3:c.460+2T>G,\N,\N,4/7,Unknown significance,\N,splice_donor_variant,22.9,0.00625,OTO_US_AF,WFS1
614154,4:6290862:G>A,NM_006005.3:c.460+4G>A,\N,\N,4/7,Unknown significance,\N,splice_region_variant&intron_variant,2.476,0.000118511,EXAC_SAS_AF,WFS1
614155,4:6290864:T>G,NM_006005.3:c.460+6T>G,\N,\N,4/7,Unknown significance,\N,splice_region_variant&intron_variant,1.877,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614156,4:6290869:G>A,NM_006005.3:c.460+11G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,0.027,0.000297796,EXAC_AFR_AF,WFS1
614157,4:6290871:G>A,NM_006005.3:c.460+13G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,6.246,0.0000695217,EXAC_NFE_AF,WFS1
614158,4:6290879:G>C,NM_006005.3:c.460+21G>C,\N,\N,4/7,Unknown significance,\N,intron_variant,1.193,0.0008,1KG_AFR_AF,WFS1
614159,4:6290881:A>C,NM_006005.3:c.460+23A>C,\N,\N,4/7,Unknown significance,\N,intron_variant,2.372,\N,\N,WFS1
614160,4:6290885:C>T,NM_006005.3:c.460+27C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,5.823,\N,\N,WFS1
614161,4:6290886:C>T,NM_006005.3:c.460+28C>T,\N,\N,4/7,Benign,\N,intron_variant,2.419,0.0356,1KG_AFR_AF,WFS1
614162,4:6290890:G>A,NM_006005.3:c.460+32G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,3.182,0.000375657,EXAC_SAS_AF,WFS1
614163,4:6290892:A>T,NM_006005.3:c.460+34A>T,\N,\N,4/7,Unknown significance,\N,intron_variant,3.535,0.000466744,EVS_EA_AF,WFS1
614164,4:6290898:G>C,NM_006005.3:c.460+40G>C,\N,\N,4/7,Unknown significance,\N,intron_variant,0.525,\N,\N,WFS1
614165,4:6290903:G>A,NM_006005.3:c.460+45G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,2.855,0.0008,1KG_AFR_AF,WFS1
614166,4:6290913:C>T,NM_006005.3:c.460+55C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,5.06,\N,\N,WFS1
614167,4:6290932:C>T,NM_006005.3:c.460+74C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,3.567,0.0015,1KG_AFR_AF,WFS1
614168,4:6290953:C>T,NM_006005.3:c.460+95C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,3.183,\N,\N,WFS1
614169,4:6290968:T>C,NM_006005.3:c.460+110T>C,\N,\N,4/7,Unknown significance,\N,intron_variant,6.151,\N,\N,WFS1
614170,4:6290980:G>T,NM_006005.3:c.460+122G>T,\N,\N,4/7,Unknown significance,\N,intron_variant,1.05,\N,\N,WFS1
614171,4:6290998:G>A,NM_006005.3:c.460+140G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,4.497,\N,\N,WFS1
614172,4:6290999:C>T,NM_006005.3:c.460+141C>T,\N,\N,4/7,Benign,\N,intron_variant,5.336,0.0139,1KG_EAS_AF,WFS1
614173,4:6291003:C>G,NM_006005.3:c.460+145C>G,\N,\N,4/7,Benign,\N,intron_variant,1.474,0.9077,1KG_EAS_AF,WFS1
614174,4:6291004:T>G,NM_006005.3:c.460+146T>G,\N,\N,4/7,Unknown significance,\N,intron_variant,3.969,\N,\N,WFS1
614175,4:6291037:G>T,NM_006005.3:c.460+179G>T,\N,\N,4/7,Unknown significance,\N,intron_variant,2.681,\N,\N,WFS1
614176,4:6291048:G>A,NM_006005.3:c.460+190G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,2.173,\N,\N,WFS1
614177,4:6291055:C>T,NM_006005.3:c.460+197C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,6.105,\N,\N,WFS1
614178,4:6291069:T>C,NM_006005.3:c.460+211T>C,\N,\N,4/7,Unknown significance,\N,intron_variant,3.916,\N,\N,WFS1
614179,4:6291111:G>C,NM_006005.3:c.460+253G>C,\N,\N,4/7,Unknown significance,\N,intron_variant,0.111,\N,\N,WFS1
614180,4:6291147:G>A,NM_006005.3:c.460+289G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,5.064,0.001,1KG_EUR_AF,WFS1
614181,4:6291171:G>A,NM_006005.3:c.460+313G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,1.467,0.001,1KG_SAS_AF,WFS1
614182,4:6291204:G>C,NM_006005.3:c.460+346G>C,\N,\N,4/7,Unknown significance,\N,intron_variant,1.071,\N,\N,WFS1
614183,4:6291214:C>A,NM_006005.3:c.460+356C>A,\N,\N,4/7,Unknown significance,\N,intron_variant,4.498,\N,\N,WFS1
614184,4:6291236:C>G,NM_006005.3:c.460+378C>G,\N,\N,4/7,Unknown significance,\N,intron_variant,2.46,0.0015,1KG_AFR_AF,WFS1
614185,4:6291239:A>T,NM_006005.3:c.460+381A>T,\N,\N,4/7,Unknown significance,\N,intron_variant,0.611,\N,\N,WFS1
614186,4:6291244:C>T,NM_006005.3:c.460+386C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,7.422,0.0008,1KG_AFR_AF,WFS1
614187,4:6291245:G>A,NM_006005.3:c.460+387G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,2.974,\N,\N,WFS1
614188,4:6291247:C>T,NM_006005.3:c.460+389C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,6.722,\N,\N,WFS1
614189,4:6291272:G>A,NM_006005.3:c.460+414G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,0.47,\N,\N,WFS1
614190,4:6291274:T>TGTGGGCCC,NM_006005.3:c.460+417_460+424dup,\N,\N,4/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614191,4:6291281:C>A,NM_006005.3:c.460+423C>A,\N,\N,4/7,Unknown significance,\N,intron_variant,2.123,\N,\N,WFS1
614192,4:6291323:G>A,NM_006005.3:c.460+465G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,2.517,0.0008,1KG_AFR_AF,WFS1
614193,4:6291329:C>A,NM_006005.3:c.460+471C>A,\N,\N,4/7,Unknown significance,\N,intron_variant,5.536,\N,\N,WFS1
614194,4:6291340:T>A,NM_006005.3:c.460+482T>A,\N,\N,4/7,Unknown significance,\N,intron_variant,3.486,\N,\N,WFS1
614195,4:6291378:C>T,NM_006005.3:c.460+520C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,6.268,0.001,1KG_EUR_AF,WFS1
614196,4:6291385:C>G,NM_006005.3:c.460+527C>G,\N,\N,4/7,Unknown significance,\N,intron_variant,1.623,0.001,1KG_EAS_AF,WFS1
614197,4:6291419:C>T,NM_006005.3:c.460+561C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,5.213,0.001,1KG_EUR_AF,WFS1
614198,4:6291426:G>A,NM_006005.3:c.460+568G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,4.705,0.0014,1KG_AMR_AF,WFS1
614199,4:6291431:G>A,NM_006005.3:c.460+573G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,2.777,0.0008,1KG_AFR_AF,WFS1
614200,4:6291436:T>G,NM_006005.3:c.460+578T>G,\N,\N,4/7,Unknown significance,\N,intron_variant,1.701,\N,\N,WFS1
614201,4:6291440:T>C,NM_006005.3:c.460+582T>C,\N,\N,4/7,Unknown significance,\N,intron_variant,1.021,0.001,1KG_EUR_AF,WFS1
614202,4:6291441:G>C,NM_006005.3:c.460+583G>C,\N,\N,4/7,Unknown significance,\N,intron_variant,1.239,0.003,1KG_EAS_AF,WFS1
614203,4:6291446:C>T,NM_006005.3:c.460+588C>T,\N,\N,4/7,Benign,\N,intron_variant,4.424,0.0151,1KG_AFR_AF,WFS1
614204,4:6291485:G>C,NM_006005.3:c.460+627G>C,\N,\N,4/7,Unknown significance,\N,intron_variant,1.507,0.0008,1KG_AFR_AF,WFS1
614205,4:6291504:C>T,NM_006005.3:c.460+646C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,3.199,\N,\N,WFS1
614206,4:6291540:A>G,NM_006005.3:c.460+682A>G,\N,\N,4/7,Unknown significance,\N,intron_variant,4.141,0.003,1KG_AFR_AF,WFS1
614207,4:6291549:G>A,NM_006005.3:c.460+691G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,1.695,0.0008,1KG_AFR_AF,WFS1
614208,4:6291622:A>G,NM_006005.3:c.460+764A>G,\N,\N,4/7,Unknown significance,\N,intron_variant,4.614,\N,\N,WFS1
614209,4:6291657:T>C,NM_006005.3:c.460+799T>C,\N,\N,4/7,Benign,\N,intron_variant,0.152,0.0189,1KG_AFR_AF,WFS1
614210,4:6291667:TTTG>T,NM_006005.3:c.460+821_460+823del,\N,\N,4/7,Benign,\N,intron_variant,3.115,0.005,1KG_EUR_AF,WFS1
614211,4:6291725:G>C,NM_006005.3:c.460+867G>C,\N,\N,4/7,Unknown significance,\N,intron_variant,0.389,\N,\N,WFS1
614212,4:6291728:C>T,NM_006005.3:c.460+870C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,0.065,\N,\N,WFS1
614213,4:6291737:G>C,NM_006005.3:c.460+879G>C,\N,\N,4/7,Benign,\N,intron_variant,0.371,0.9038,1KG_EAS_AF,WFS1
614214,4:6291757:C>A,NM_006005.3:c.460+899C>A,\N,\N,4/7,Unknown significance,\N,intron_variant,1.248,0.0023,1KG_AFR_AF,WFS1
614215,4:6291769:A>G,NM_006005.3:c.460+911A>G,\N,\N,4/7,Unknown significance,\N,intron_variant,4.26,\N,\N,WFS1
614216,4:6291782:C>T,NM_006005.3:c.460+924C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,0.959,\N,\N,WFS1
614217,4:6291793:GTAGC>G,NM_006005.3:c.460+937_460+940del,\N,\N,4/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614218,4:6291824:C>T,NM_006005.3:c.460+966C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,2.857,0.002,1KG_SAS_AF,WFS1
614219,4:6291826:TA>T,NM_006005.3:c.460+969del,\N,\N,4/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614220,4:6291865:C>T,NM_006005.3:c.460+1007C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,3.622,\N,\N,WFS1
614221,4:6291877:G>C,NM_006005.3:c.460+1019G>C,\N,\N,4/7,Unknown significance,\N,intron_variant,1.075,\N,\N,WFS1
614222,4:6291902:G>A,NM_006005.3:c.461-1022G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,4.024,0.001,1KG_SAS_AF,WFS1
614223,4:6291903:G>T,NM_006005.3:c.461-1021G>T,\N,\N,4/7,Benign,\N,intron_variant,1.472,0.9038,1KG_EAS_AF,WFS1
614224,4:6291915:C>T,NM_006005.3:c.461-1009C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,2.357,0.0008,1KG_AFR_AF,WFS1
614225,4:6291932:A>C,NM_006005.3:c.461-992A>C,\N,\N,4/7,Unknown significance,\N,intron_variant,0.245,\N,\N,WFS1
614226,4:6291935:A>G,NM_006005.3:c.461-989A>G,\N,\N,4/7,Unknown significance,\N,intron_variant,0.761,\N,\N,WFS1
614227,4:6291938:G>T,NM_006005.3:c.461-986G>T,\N,\N,4/7,Unknown significance,\N,intron_variant,0.119,\N,\N,WFS1
614228,4:6291946:G>A,NM_006005.3:c.461-978G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,1.385,0.0014,1KG_AMR_AF,WFS1
614229,4:6291955:C>T,NM_006005.3:c.461-969C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,0.171,0.001,1KG_EAS_AF,WFS1
614230,4:6291966:T>A,NM_006005.3:c.461-958T>A,\N,\N,4/7,Unknown significance,\N,intron_variant,4.982,0.003,1KG_AFR_AF,WFS1
614231,4:6291967:G>A,NM_006005.3:c.461-957G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,2.054,0.001,1KG_SAS_AF,WFS1
614232,4:6292019:T>G,NM_006005.3:c.461-905T>G,\N,\N,4/7,Unknown significance,\N,intron_variant,2.943,0.0008,1KG_AFR_AF,WFS1
614233,4:6292020:A>C,NM_006005.3:c.461-904A>C,\N,\N,4/7,Benign,\N,intron_variant,1.131,0.9077,1KG_EAS_AF,WFS1
614234,4:6292126:C>T,NM_006005.3:c.461-798C>T,\N,\N,4/7,Benign,\N,intron_variant,2.869,0.0051,1KG_SAS_AF,WFS1
614235,4:6292131:C>A,NM_006005.3:c.461-793C>A,\N,\N,4/7,Unknown significance,\N,intron_variant,3.173,\N,\N,WFS1
614236,4:6292136:G>A,NM_006005.3:c.461-788G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,0.353,0.0015,1KG_AFR_AF,WFS1
614237,4:6292163:C>T,NM_006005.3:c.461-761C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,6.245,0.0014,1KG_AMR_AF,WFS1
614238,4:6292181:G>A,NM_006005.3:c.461-743G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,1.987,0.0041,1KG_SAS_AF,WFS1
614239,4:6292198:G>GT,NM_006005.3:c.461-726_461-725insT,\N,\N,4/7,Benign,\N,intron_variant,3.324,0.008,1KG_EUR_AF,WFS1
614240,4:6292240:A>T,NM_006005.3:c.461-684A>T,\N,\N,4/7,Unknown significance,\N,intron_variant,0.938,0.001,1KG_EAS_AF,WFS1
614241,4:6292248:T>C,NM_006005.3:c.461-676T>C,\N,\N,4/7,Benign,\N,intron_variant,0.465,0.0545,1KG_AFR_AF,WFS1
614242,4:6292256:T>C,NM_006005.3:c.461-668T>C,\N,\N,4/7,Unknown significance,\N,intron_variant,7.12,0.001,1KG_EUR_AF,WFS1
614243,4:6292258:T>C,NM_006005.3:c.461-666T>C,\N,\N,4/7,Unknown significance,\N,intron_variant,8.613,0.0023,1KG_AFR_AF,WFS1
614244,4:6292272:A>G,NM_006005.3:c.461-652A>G,\N,\N,4/7,Unknown significance,\N,intron_variant,2.438,0.001,1KG_EAS_AF,WFS1
614245,4:6292281:CAT>C,NM_006005.3:c.461-642_461-641del,\N,\N,4/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614246,4:6292307:A>G,NM_006005.3:c.461-617A>G,\N,\N,4/7,Benign,\N,intron_variant,3.362,0.0545,1KG_AFR_AF,WFS1
614247,4:6292379:G>A,NM_006005.3:c.461-545G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,0.757,0.001,1KG_SAS_AF,WFS1
614248,4:6292383:G>C,NM_006005.3:c.461-541G>C,\N,\N,4/7,Unknown significance,\N,intron_variant,0.04,0.001,1KG_EUR_AF,WFS1
614249,4:6292388:A>G,NM_006005.3:c.461-536A>G,\N,\N,4/7,Unknown significance,\N,intron_variant,1.666,\N,\N,WFS1
614250,4:6292432:C>A,NM_006005.3:c.461-492C>A,\N,\N,4/7,Benign,\N,intron_variant,3.07,0.0151,1KG_AFR_AF,WFS1
614251,4:6292533:C>T,NM_006005.3:c.461-391C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,2.038,\N,\N,WFS1
614252,4:6292621:G>A,NM_006005.3:c.461-303G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,3.829,0.003,1KG_AFR_AF,WFS1
614253,4:6292629:G>C,NM_006005.3:c.461-295G>C,\N,\N,4/7,Unknown significance,\N,intron_variant,2.144,\N,\N,WFS1
614254,4:6292641:C>G,NM_006005.3:c.461-283C>G,\N,\N,4/7,Unknown significance,\N,intron_variant,1.497,\N,\N,WFS1
614255,4:6292643:G>C,NM_006005.3:c.461-281G>C,\N,\N,4/7,Benign,\N,intron_variant,0.281,0.9038,1KG_EAS_AF,WFS1
614256,4:6292680:C>T,NM_006005.3:c.461-244C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,2.516,0.003,1KG_EUR_AF,WFS1
614257,4:6292702:G>A,NM_006005.3:c.461-222G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,0.415,0.0015,1KG_AFR_AF,WFS1
614258,4:6292707:C>T,NM_006005.3:c.461-217C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,2.581,0.0008,1KG_AFR_AF,WFS1
614259,4:6292716:G>C,NM_006005.3:c.461-208G>C,\N,\N,4/7,Benign,\N,intron_variant,0.354,0.9038,1KG_EAS_AF,WFS1
614260,4:6292717:G>A,NM_006005.3:c.461-207G>A,\N,\N,4/7,Benign,\N,intron_variant,0.635,0.0072,1KG_AMR_AF,WFS1
614261,4:6292745:G>A,NM_006005.3:c.461-179G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,3.088,\N,\N,WFS1
614262,4:6292746:T>TGGGCGTGGCAG,NM_006005.3:c.461-169_461-168insAGGGGCGTGGC,\N,\N,4/7,Unknown significance,\N,intron_variant,1.79,\N,\N,WFS1
614263,4:6292750:C>CAT,NM_006005.3:c.461-174_461-173insAT,\N,\N,4/7,Unknown significance,\N,intron_variant,6.969,\N,\N,WFS1
614264,4:6292751:G>A,NM_006005.3:c.461-173G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,3.588,\N,\N,WFS1
614265,4:6292751:G>GTGGCAGGGGCA,NM_006005.3:c.461-169_461-168insAGGGGCATGGC,\N,\N,4/7,Unknown significance,\N,intron_variant,0.82,\N,\N,WFS1
614266,4:6292755:C>CAGGGGCATG,NM_006005.3:c.461-169_461-168insAGGGGCATG,\N,\N,4/7,Benign,\N,intron_variant,4.1,0.4534,1KG_EAS_AF,WFS1
614267,4:6292756:G>A,NM_006005.3:c.461-168G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,2.91,\N,\N,WFS1
614268,4:6292756:GCG>AGGGGCATGGCGCA,NM_006005.3:c.461-168_461-166delinsAGGGGCATGGCGCA,\N,\N,4/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614269,4:6292757:C>G,NM_006005.3:c.461-167C>G,\N,\N,4/7,Unknown significance,\N,intron_variant,0.601,\N,\N,WFS1
614270,4:6292758:G>A,NM_006005.3:c.461-166G>A,\N,\N,4/7,Benign,\N,intron_variant,3.494,0.4534,1KG_EAS_AF,WFS1
614271,4:6292758:G>GCA,NM_006005.3:c.461-166_461-165insCA,\N,\N,4/7,Benign,\N,intron_variant,3.182,0.4494,1KG_EAS_AF,WFS1
614272,4:6292758:G>GGCATGGCGCA,NM_006005.3:c.461-166_461-165insGCATGGCGCA,\N,\N,4/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614273,4:6292758:G>GGGCATGGCGCA,NM_006005.3:c.461-166_461-165insGGCATGGCGCA,\N,\N,4/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614274,4:6292758:G>T,NM_006005.3:c.461-166G>T,\N,\N,4/7,Unknown significance,\N,intron_variant,2.155,\N,\N,WFS1
614275,4:6292764:C>T,NM_006005.3:c.461-160C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,5.747,0.002,1KG_EUR_AF,WFS1
614276,4:6292792:C>T,NM_006005.3:c.461-132C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,6.916,0.002,1KG_EAS_AF,WFS1
614277,4:6292799:A>C,NM_006005.3:c.461-125A>C,\N,\N,4/7,Benign,\N,intron_variant,2.165,0.9077,1KG_EAS_AF,WFS1
614278,4:6292814:C>G,NM_006005.3:c.461-110C>G,\N,\N,4/7,Unknown significance,\N,intron_variant,3.957,0.001,1KG_EUR_AF,WFS1
614279,4:6292818:C>G,NM_006005.3:c.461-106C>G,\N,\N,4/7,Benign,\N,intron_variant,1.981,0.9077,1KG_EAS_AF,WFS1
614280,4:6292820:A>G,NM_006005.3:c.461-104A>G,\N,\N,4/7,Unknown significance,\N,intron_variant,4.076,\N,\N,WFS1
614281,4:6292832:C>T,NM_006005.3:c.461-92C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,5.791,0.0014,1KG_AMR_AF,WFS1
614282,4:6292833:G>A,NM_006005.3:c.461-91G>A,\N,\N,4/7,Benign,\N,intron_variant,1.868,0.0567,1KG_AFR_AF,WFS1
614283,4:6292842:C>G,NM_006005.3:c.461-82C>G,\N,\N,4/7,Unknown significance,\N,intron_variant,4.897,\N,\N,WFS1
614284,4:6292862:C>G,NM_006005.3:c.461-62C>G,\N,\N,4/7,Unknown significance,\N,intron_variant,3.762,\N,\N,WFS1
614285,4:6292874:G>A,NM_006005.3:c.461-50G>A,\N,\N,4/7,Unknown significance,\N,intron_variant,2.783,0.0000458323,EXAC_NFE_AF,WFS1
614286,4:6292890:C>T,NM_006005.3:c.461-34C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,4.912,0.001,1KG_EUR_AF,WFS1
614287,4:6292894:C>G,NM_006005.3:c.461-30C>G,\N,\N,4/7,Unknown significance,\N,intron_variant,4.294,0.0000152341,EXAC_NFE_AF,WFS1
614288,4:6292899:C>A,NM_006005.3:c.461-25C>A,\N,\N,4/7,Unknown significance,\N,intron_variant,6.807,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614289,4:6292909:C>T,NM_006005.3:c.461-15C>T,\N,\N,4/7,Benign,\N,intron_variant,3.427,0.922719,EXAC_EAS_AF,WFS1
614290,4:6292912:C>T,NM_006005.3:c.461-12C>T,\N,\N,4/7,Unknown significance,\N,intron_variant,2.974,\N,\N,WFS1
614291,4:6292915:A>G,NM_006005.3:c.461-9A>G,\N,\N,4/7,Benign,\N,intron_variant,4.317,0.934767,EXAC_EAS_AF,WFS1
614292,4:6292921:C>G,NM_006005.3:c.461-3C>G,\N,\N,4/7,Unknown significance,\N,splice_region_variant&intron_variant,4.295,\N,\N,WFS1
614293,4:6292924:G>C,NM_006005.3:c.461G>C,NP_005996.2:p.Gly154Ala,5/8,\N,Unknown significance,\N,missense_variant&splice_region_variant,24,\N,\N,WFS1
614294,4:6292930:C>T,NM_006005.3:c.467C>T,NP_005996.2:p.Thr156Met,5/8,\N,Pathogenic,Wolfram syndrome,missense_variant,27.9,0.000151332,EXAC_FIN_AF,WFS1
614295,4:6292931:G>A,NM_006005.3:c.468G>A,NP_005996.2:p.Thr156=,5/8,\N,Unknown significance,\N,synonymous_variant,7.51,0.0000865801,EXAC_AMR_AF,WFS1
614296,4:6292931:G>T,NM_006005.3:c.468G>T,NP_005996.2:p.Thr156=,5/8,\N,Unknown significance,\N,synonymous_variant,1.459,0.0014,1KG_AMR_AF,WFS1
614297,4:6292934:C>G,NM_006005.3:c.471C>G,NP_005996.2:p.Ser157=,5/8,\N,Unknown significance,\N,synonymous_variant,8.587,0.000363504,EXAC_SAS_AF,WFS1
614298,4:6292934:C>T,NM_006005.3:c.471C>T,NP_005996.2:p.Ser157=,5/8,\N,Unknown significance,\N,synonymous_variant,10.86,0.000432975,EXAC_AMR_AF,WFS1
614299,4:6292935:G>A,NM_006005.3:c.472G>A,NP_005996.2:p.Glu158Lys,5/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.8,0.0014,1KG_AMR_AF,WFS1
614300,4:6292937:G>A,NM_006005.3:c.474G>A,NP_005996.2:p.Glu158=,5/8,\N,Unknown significance,\N,synonymous_variant,6.851,0.001,1KG_SAS_AF,WFS1
614301,4:6292939:A>G,NM_006005.3:c.476A>G,NP_005996.2:p.Asn159Ser,5/8,\N,Unknown significance,\N,missense_variant,23.6,0.0000302636,EXAC_NFE_AF,WFS1
614302,4:6292940:C>T,NM_006005.3:c.477C>T,NP_005996.2:p.Asn159=,5/8,\N,Unknown significance,\N,synonymous_variant,8.502,0.00043305,EXAC_AMR_AF,WFS1
614303,4:6292944:C>T,NM_006005.3:c.481C>T,NP_005996.2:p.Arg161Trp,5/8,\N,Unknown significance,\N,missense_variant,21.3,0.0000972952,EXAC_AFR_AF,WFS1
614304,4:6292945:G>A,NM_006005.3:c.482G>A,NP_005996.2:p.Arg161Gln,5/8,\N,Benign,\N,missense_variant,3.159,0.0159,1KG_AFR_AF,WFS1
614305,4:6292951:T>G,NM_006005.3:c.488T>G,NP_005996.2:p.Val163Gly,5/8,\N,Benign,\N,missense_variant,24.3,0.015,OTO_TR_AF,WFS1
614306,4:6292958:G>A,NM_006005.3:c.495G>A,NP_005996.2:p.Gln165=,5/8,\N,Unknown significance,\N,synonymous_variant,0.588,0.000151378,EXAC_FIN_AF,WFS1
614307,4:6292961:C>G,NM_006005.3:c.498C>G,NP_005996.2:p.Leu166=,5/8,\N,Unknown significance,\N,synonymous_variant,7.796,0.000194818,EXAC_AFR_AF,WFS1
614308,4:6292967:C>T,NM_006005.3:c.504C>T,NP_005996.2:p.Ser168=,5/8,\N,Unknown significance,\N,synonymous_variant,14.95,0.0008,1KG_AFR_AF,WFS1
614309,4:6292968:G>A,NM_006005.3:c.505G>A,NP_005996.2:p.Glu169Lys,5/8,\N,Unknown significance,\N,missense_variant,26.4,0.000232558,EVS_EA_AF,WFS1
614310,4:6292973:C>G,NM_006005.3:c.510C>G,NP_005996.2:p.Thr170=,5/8,\N,Benign,\N,synonymous_variant,12.31,0.0119,1KG_EAS_AF,WFS1
614311,4:6292973:C>T,NM_006005.3:c.510C>T,NP_005996.2:p.Thr170=,5/8,\N,Unknown significance,\N,synonymous_variant,14.79,0.000232558,EVS_EA_AF,WFS1
614312,4:6292974:G>A,NM_006005.3:c.511G>A,NP_005996.2:p.Asp171Asn,5/8,\N,Pathogenic,Sensorineural hearing loss| nonsyndromic,missense_variant,24.7,0.000757805,EXAC_FIN_AF,WFS1
614313,4:6292974:G>C,NM_006005.3:c.511G>C,NP_005996.2:p.Asp171His,5/8,\N,Unknown significance,\N,missense_variant,24.5,0.0000151291,EXAC_NFE_AF,WFS1
614314,4:6292977:C>T,NM_006005.3:c.514C>T,NP_005996.2:p.Leu172=,5/8,\N,Unknown significance,\N,synonymous_variant,13.66,0.000453926,EVS_AA_AF,WFS1
614315,4:6292988:C>T,NM_006005.3:c.525C>T,NP_005996.2:p.Ala175=,5/8,\N,Unknown significance,\N,synonymous_variant,20.3,0.000015135,EXAC_NFE_AF,WFS1
614316,4:6292989:G>A,NM_006005.3:c.526G>A,NP_005996.2:p.Val176Met,5/8,\N,Unknown significance,\N,missense_variant,32,0.0000606061,EXAC_SAS_AF,WFS1
614317,4:6292990:T>C,NM_006005.3:c.527T>C,NP_005996.2:p.Val176Ala,5/8,\N,Unknown significance,\N,missense_variant,14.68,0.0000151382,EXAC_NFE_AF,WFS1
614318,4:6292992:C>A,NM_006005.3:c.529C>A,NP_005996.2:p.Arg177Ser,5/8,\N,Unknown significance,\N,missense_variant,33,0.000115848,EXAC_EAS_AF,WFS1
614319,4:6292993:G>A,NM_006005.3:c.530G>A,NP_005996.2:p.Arg177His,5/8,\N,Unknown significance,\N,missense_variant,34,0.0000151396,EXAC_NFE_AF,WFS1
614320,4:6292993:G>C,NM_006005.3:c.530G>C,NP_005996.2:p.Arg177Pro,5/8,\N,Pathogenic,Wolfram syndrome,missense_variant,34,\N,\N,WFS1
614321,4:6292994:CAAGGCA>C,NM_006005.3:c.532_537del,NP_005996.2:p.Lys178_Ala179del,5/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,\N,\N,\N,WFS1
614322,4:6292995:AAGGCAG>A,NM_006005.3:c.533_538del,NP_005996.2:p.Lys178_Ala180delinsThr,5/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,22.3,\N,\N,WFS1
614323,4:6292998:G>A,NM_006005.3:c.535G>A,NP_005996.2:p.Ala179Thr,5/8,\N,Unknown significance,\N,missense_variant,28,0.000231696,EXAC_EAS_AF,WFS1
614324,4:6293004:C>T,NM_006005.3:c.541C>T,NP_005996.2:p.Leu181=,5/8,\N,Unknown significance,\N,synonymous_variant,15.84,0.0000151382,EXAC_NFE_AF,WFS1
614325,4:6293006:G>C,NM_006005.3:c.543G>C,NP_005996.2:p.Leu181=,5/8,\N,Unknown significance,\N,synonymous_variant,10.32,0.000116279,EVS_EA_AF,WFS1
614326,4:6293015:C>G,NM_006005.3:c.552C>G,NP_005996.2:p.Tyr184Ter,5/8,\N,Unknown significance,\N,stop_gained,36,0.0000867303,EXAC_AMR_AF,WFS1
614327,4:6293017:G>A,NM_006005.3:c.554G>A,NP_005996.2:p.Trp185Ter,5/8,\N,Unknown significance,\N,stop_gained,38,0.000115848,EXAC_EAS_AF,WFS1
614328,4:6293026:A>G,NM_006005.3:c.563A>G,NP_005996.2:p.Asn188Ser,5/8,\N,Pathogenic,Wolfram syndrome,missense_variant,18.5,\N,\N,WFS1
614329,4:6293030:C>CAAG,NM_006005.3:c.577_579dup,NP_005996.2:p.Lys193dup,5/8,\N,Unknown significance,\N,inframe_insertion,\N,0.000231589,EXAC_EAS_AF,WFS1
614330,4:6293030:CAAG>C,NM_006005.3:c.577_579del,NP_005996.2:p.Lys193del,5/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,21.1,0.0000606281,EXAC_SAS_AF,WFS1
614331,4:6293031:A>C,NM_006005.3:c.568A>C,NP_005996.2:p.Lys190Gln,5/8,\N,Unknown significance,\N,missense_variant,14.66,0.0000868056,EXAC_AMR_AF,WFS1
614332,4:6293031:A>G,NM_006005.3:c.568A>G,NP_005996.2:p.Lys190Glu,5/8,\N,Unknown significance,\N,missense_variant,14.19,0.001,1KG_EAS_AF,WFS1
614333,4:6293035:A>G,NM_006005.3:c.572A>G,NP_005996.2:p.Lys191Arg,5/8,\N,Likely benign,\N,missense_variant,11.77,0.000453926,EVS_AA_AF,WFS1
614334,4:6293036:G>A,NM_006005.3:c.573G>A,NP_005996.2:p.Lys191=,5/8,\N,Unknown significance,\N,synonymous_variant,14.28,0.0000606281,EXAC_SAS_AF,WFS1
614335,4:6293039:G>GA,NM_006005.3:c.578dup,NP_005996.2:p.Gln194AlafsTer53,5/8,\N,Unknown significance,\N,frameshift_variant,34,0.000098174,EXAC_AFR_AF,WFS1
614336,4:6293040:A>C,NM_006005.3:c.577A>C,NP_005996.2:p.Lys193Gln,5/8,\N,Benign,\N,missense_variant,17.83,0.015,OTO_AJ_AF,WFS1
614337,4:6293040:A>AAGG,NM_006005.3:c.579_580insGAG,NP_005996.2:p.Lys193_Gln194insGlu,5/8,\N,Unknown significance,\N,inframe_insertion,11.17,0.0000606575,EXAC_SAS_AF,WFS1
614338,4:6293043:C>T,NM_006005.3:c.580C>T,NP_005996.2:p.Gln194Ter,5/8,\N,Pathogenic,Wolfram syndrome,stop_gained,37,\N,\N,WFS1
614339,4:6293047:T>G,NM_006005.3:c.584T>G,NP_005996.2:p.Val195Gly,5/8,\N,Unknown significance,\N,missense_variant,27.1,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614340,4:6293051:C>T,NM_006005.3:c.588C>T,NP_005996.2:p.Ala196=,5/8,\N,Unknown significance,\N,synonymous_variant,17.57,0.001,1KG_SAS_AF,WFS1
614341,4:6293056:C>T,NM_006005.3:c.593C>T,NP_005996.2:p.Ala198Val,5/8,\N,Unknown significance,\N,missense_variant,24.3,0.000226963,EVS_AA_AF,WFS1
614342,4:6293057:G>A,NM_006005.3:c.594G>A,NP_005996.2:p.Ala198=,5/8,\N,Benign,\N,synonymous_variant,14.24,0.0061,1KG_SAS_AF,WFS1
614343,4:6293058:G>C,NM_006005.3:c.595G>C,NP_005996.2:p.Glu199Gln,5/8,\N,Unknown significance,\N,missense_variant,24.4,0.000115955,EXAC_EAS_AF,WFS1
614344,4:6293061:CT>C,NM_006005.3:c.599del,NP_005996.2:p.Leu200ArgfsTer87,5/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,34,\N,\N,WFS1
614345,4:6293062:T>C,NM_006005.3:c.599T>C,NP_005996.2:p.Leu200Pro,5/8,\N,Pathogenic,Wolfram syndrome,missense_variant,28,\N,\N,WFS1
614346,4:6293064:C>A,NM_006005.3:c.601C>A,NP_005996.2:p.Leu201Met,5/8,\N,Unknown significance,\N,missense_variant,26.2,0.0008,1KG_AFR_AF,WFS1
614347,4:6293067:G>A,NM_006005.3:c.604G>A,NP_005996.2:p.Glu202Lys,5/8,\N,Unknown significance,\N,missense_variant,26.3,0.000158078,EXAC_FIN_AF,WFS1
614348,4:6293068:A>G,NM_006005.3:c.605A>G,NP_005996.2:p.Glu202Gly,5/8,\N,Pathogenic,Wolfram syndrome,missense_variant,29.4,\N,\N,WFS1
614349,4:6293071:A>G,NM_006005.3:c.608A>G,NP_005996.2:p.Asn203Ser,5/8,\N,Unknown significance,\N,missense_variant,23,\N,\N,WFS1
614350,4:6293072:T>C,NM_006005.3:c.609T>C,NP_005996.2:p.Asn203=,5/8,\N,Unknown significance,\N,synonymous_variant,0.02,0.0000609236,EXAC_SAS_AF,WFS1
614351,4:6293075:C>T,NM_006005.3:c.612C>T,NP_005996.2:p.Val204=,5/8,\N,Unknown significance,\N,synonymous_variant,12.65,0.0008,1KG_AFR_AF,WFS1
614352,4:6293076:G>A,NM_006005.3:c.613G>A,NP_005996.2:p.Gly205Ser,5/8,\N,Unknown significance,\N,missense_variant,23.1,0.000348513,EXAC_EAS_AF,WFS1
614353,4:6293083:T>G,NM_006005.3:c.620T>G,NP_005996.2:p.Val207Gly,5/8,\N,Unknown significance,\N,missense_variant,24.8,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614354,4:6293086:A>C,NM_006005.3:c.623A>C,NP_005996.2:p.Asn208Thr,5/8,\N,Unknown significance,\N,missense_variant,22.4,0.0000309425,EXAC_NFE_AF,WFS1
614355,4:6293087:C>T,NM_006005.3:c.624C>T,NP_005996.2:p.Asn208=,5/8,\N,Unknown significance,\N,synonymous_variant,10.55,0.000615439,EXAC_AMR_AF,WFS1
614356,4:6293088:G>A,NM_006005.3:c.625G>A,NP_005996.2:p.Glu209Lys,5/8,\N,Unknown significance,\N,missense_variant,11.89,0.0000155145,EXAC_NFE_AF,WFS1
614357,4:6293093:C>T,NM_006005.3:c.630C>T,NP_005996.2:p.His210=,5/8,\N,Unknown significance,\N,splice_region_variant&synonymous_variant,0.161,0.000116279,EVS_EA_AF,WFS1
614358,4:6293094:G>A,NM_006005.3:c.631G>A,NP_005996.2:p.Asp211Asn,5/8,\N,Pathogenic,Wolfram syndrome,missense_variant&splice_region_variant,23.8,0.000116279,EVS_EA_AF,WFS1
614359,4:6293096:T>G,NM_006005.3:c.631+2T>G,\N,\N,5/7,Unknown significance,\N,splice_donor_variant,21.9,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614360,4:6293097:G>A,NM_006005.3:c.631+3G>A,\N,\N,5/7,Unknown significance,\N,splice_region_variant&intron_variant,3.152,0.0000889838,EXAC_AMR_AF,WFS1
614361,4:6293098:C>G,NM_006005.3:c.631+4C>G,\N,\N,5/7,Unknown significance,\N,splice_region_variant&intron_variant,2.23,0.000116279,EVS_EA_AF,WFS1
614362,4:6293098:C>T,NM_006005.3:c.631+4C>T,\N,\N,5/7,Unknown significance,\N,splice_region_variant&intron_variant,4.62,0.000310366,EXAC_AFR_AF,WFS1
614363,4:6293099:G>A,NM_006005.3:c.631+5G>A,\N,\N,5/7,Unknown significance,\N,splice_region_variant&intron_variant,6.867,\N,\N,WFS1
614364,4:6293102:G>C,NM_006005.3:c.631+8G>C,\N,\N,5/7,Unknown significance,\N,splice_region_variant&intron_variant,1.442,0.0000158273,EXAC_NFE_AF,WFS1
614365,4:6293105:T>C,NM_006005.3:c.631+11T>C,\N,\N,5/7,Unknown significance,\N,intron_variant,2.896,0.000104646,EXAC_AFR_AF,WFS1
614366,4:6293106:C>T,NM_006005.3:c.631+12C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,5.178,0.003,1KG_AFR_AF,WFS1
614367,4:6293107:A>C,NM_006005.3:c.631+13A>C,\N,\N,5/7,Benign,\N,intron_variant,1.288,0.02,OTO_TR_AF,WFS1
614368,4:6293108:C>CCA,NM_006005.3:c.631+15_631+16insAC,\N,\N,5/7,Unknown significance,\N,intron_variant,4.235,0.0000159852,EXAC_NFE_AF,WFS1
614369,4:6293111:T>TC,NM_006005.3:c.631+17_631+18insC,\N,\N,5/7,Unknown significance,\N,intron_variant,1.282,0.000016057,EXAC_NFE_AF,WFS1
614370,4:6293112:G>GCACCACGGTGCGAGGAA,NM_006005.3:c.631+18_631+19insCACCACGGTGCGAGGAA,\N,\N,5/7,Unknown significance,\N,intron_variant,5.524,\N,\N,WFS1
614371,4:6293116:A>G,NM_006005.3:c.631+22A>G,\N,\N,5/7,Unknown significance,\N,intron_variant,7.397,0.001,1KG_SAS_AF,WFS1
614372,4:6293116:ACCAGCCTTCCCTGGGCG>A,NM_006005.3:c.631+34_631+50del,\N,\N,5/7,Unknown significance,\N,intron_variant,7.455,0.000179856,EXAC_FIN_AF,WFS1
614373,4:6293117:C>T,NM_006005.3:c.631+23C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,7.406,0.000124285,EXAC_EAS_AF,WFS1
614374,4:6293118:C>T,NM_006005.3:c.631+24C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,6.601,0.0000162296,EXAC_NFE_AF,WFS1
614375,4:6293119:A>G,NM_006005.3:c.631+25A>G,\N,\N,5/7,Unknown significance,\N,intron_variant,6.752,\N,\N,WFS1
614376,4:6293124:T>C,NM_006005.3:c.631+30T>C,\N,\N,5/7,Unknown significance,\N,intron_variant,4.837,0.0000164409,EXAC_NFE_AF,WFS1
614377,4:6293125:C>G,NM_006005.3:c.631+31C>G,\N,\N,5/7,Unknown significance,\N,intron_variant,4.371,0.0000638651,EXAC_SAS_AF,WFS1
614378,4:6293132:C>T,NM_006005.3:c.631+38C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,0.367,0.000111682,EXAC_AFR_AF,WFS1
614379,4:6293133:G>A,NM_006005.3:c.631+39G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,3.987,0.0000339156,EXAC_NFE_AF,WFS1
614380,4:6293143:C>G,NM_006005.3:c.631+49C>G,\N,\N,5/7,Unknown significance,\N,intron_variant,3.743,0.000132926,EXAC_SAS_AF,WFS1
614381,4:6293145:A>G,NM_006005.3:c.631+51A>G,\N,\N,5/7,Unknown significance,\N,intron_variant,4.266,0.000017466,EXAC_NFE_AF,WFS1
614382,4:6293146:C>T,NM_006005.3:c.631+52C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,1.417,\N,\N,WFS1
614383,4:6293213:G>A,NM_006005.3:c.631+119G>A,\N,\N,5/7,Benign,\N,intron_variant,0.711,0.006,1KG_EAS_AF,WFS1
614384,4:6293215:G>A,NM_006005.3:c.631+121G>A,\N,\N,5/7,Benign,\N,intron_variant,5.784,0.006,1KG_EAS_AF,WFS1
614385,4:6293220:TC>T,NM_006005.3:c.631+129del,\N,\N,5/7,Unknown significance,\N,intron_variant,1.171,0.004,1KG_EAS_AF,WFS1
614386,4:6293231:A>G,NM_006005.3:c.631+137A>G,\N,\N,5/7,Benign,\N,intron_variant,2.104,0.0521,1KG_SAS_AF,WFS1
614387,4:6293232:CA>C,NM_006005.3:c.631+139del,\N,\N,5/7,Unknown significance,\N,intron_variant,3.892,\N,\N,WFS1
614388,4:6293233:A>C,NM_006005.3:c.631+139A>C,\N,\N,5/7,Benign,\N,intron_variant,0.246,0.005,1KG_EAS_AF,WFS1
614389,4:6293235:G>T,NM_006005.3:c.631+141G>T,\N,\N,5/7,Benign,\N,intron_variant,2.152,0.006,1KG_EAS_AF,WFS1
614390,4:6293237:C>G,NM_006005.3:c.631+143C>G,\N,\N,5/7,Benign,\N,intron_variant,0.607,0.8978,1KG_EAS_AF,WFS1
614391,4:6293238:C>T,NM_006005.3:c.631+144C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,3.712,0.001,1KG_EUR_AF,WFS1
614392,4:6293255:A>AG,NM_006005.3:c.631+165dup,\N,\N,5/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614393,4:6293258:G>C,NM_006005.3:c.631+164G>C,\N,\N,5/7,Benign,\N,intron_variant,3.905,0.0756,1KG_AFR_AF,WFS1
614394,4:6293272:C>T,NM_006005.3:c.631+178C>T,\N,\N,5/7,Benign,\N,intron_variant,10.65,0.0098,1KG_AFR_AF,WFS1
614395,4:6293274:G>C,NM_006005.3:c.631+180G>C,\N,\N,5/7,Unknown significance,\N,intron_variant,9.287,0.0015,1KG_AFR_AF,WFS1
614396,4:6293283:G>A,NM_006005.3:c.631+189G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,0.344,\N,\N,WFS1
614397,4:6293288:C>G,NM_006005.3:c.631+194C>G,\N,\N,5/7,Unknown significance,\N,intron_variant,2.11,\N,\N,WFS1
614398,4:6293294:G>A,NM_006005.3:c.631+200G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,2.304,0.001,1KG_EAS_AF,WFS1
614399,4:6293294:G>T,NM_006005.3:c.631+200G>T,\N,\N,5/7,Unknown significance,\N,intron_variant,1.167,\N,\N,WFS1
614400,4:6293309:G>A,NM_006005.3:c.631+215G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,2.556,\N,\N,WFS1
614401,4:6293327:G>T,NM_006005.3:c.631+233G>T,\N,\N,5/7,Unknown significance,\N,intron_variant,5.358,\N,\N,WFS1
614402,4:6293350:T>C,NM_006005.3:c.631+256T>C,\N,\N,5/7,Benign,\N,intron_variant,1.401,0.9038,1KG_EAS_AF,WFS1
614403,4:6293365:G>A,NM_006005.3:c.631+271G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,5.098,\N,\N,WFS1
614404,4:6293381:C>T,NM_006005.3:c.632-263C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,6.6,\N,\N,WFS1
614405,4:6293383:C>G,NM_006005.3:c.632-261C>G,\N,\N,5/7,Unknown significance,\N,intron_variant,5.376,\N,\N,WFS1
614406,4:6293399:C>A,NM_006005.3:c.632-245C>A,\N,\N,5/7,Unknown significance,\N,intron_variant,2.453,0.0015,1KG_AFR_AF,WFS1
614407,4:6293408:G>A,NM_006005.3:c.632-236G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,1.435,\N,\N,WFS1
614408,4:6293408:G>T,NM_006005.3:c.632-236G>T,\N,\N,5/7,Unknown significance,\N,intron_variant,0.293,\N,\N,WFS1
614409,4:6293409:G>T,NM_006005.3:c.632-235G>T,\N,\N,5/7,Unknown significance,\N,intron_variant,2.256,0.0008,1KG_AFR_AF,WFS1
614410,4:6293431:G>A,NM_006005.3:c.632-213G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,7.356,0.001,1KG_EUR_AF,WFS1
614411,4:6293433:G>A,NM_006005.3:c.632-211G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,5.098,0.001,1KG_EAS_AF,WFS1
614412,4:6293434:C>T,NM_006005.3:c.632-210C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,6.092,\N,\N,WFS1
614413,4:6293436:C>T,NM_006005.3:c.632-208C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,3.949,\N,\N,WFS1
614414,4:6293446:T>C,NM_006005.3:c.632-198T>C,\N,\N,5/7,Benign,\N,intron_variant,0.469,0.9038,1KG_EAS_AF,WFS1
614415,4:6293474:A>G,NM_006005.3:c.632-170A>G,\N,\N,5/7,Benign,\N,intron_variant,3.531,0.9028,1KG_EAS_AF,WFS1
614416,4:6293515:T>G,NM_006005.3:c.632-129T>G,\N,\N,5/7,Unknown significance,\N,intron_variant,2.942,0.0008,1KG_AFR_AF,WFS1
614417,4:6293518:TC>T,NM_006005.3:c.632-122del,\N,\N,5/7,Benign,\N,intron_variant,4.718,0.0545,1KG_AFR_AF,WFS1
614418,4:6293528:G>A,NM_006005.3:c.632-116G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,0.212,\N,\N,WFS1
614419,4:6293538:C>T,NM_006005.3:c.632-106C>T,\N,\N,5/7,Benign,\N,intron_variant,6.551,0.0399,1KG_SAS_AF,WFS1
614420,4:6293539:CT>C,NM_006005.3:c.632-104del,\N,\N,5/7,Unknown significance,\N,intron_variant,2.073,\N,\N,WFS1
614421,4:6293550:G>A,NM_006005.3:c.632-94G>A,\N,\N,5/7,Benign,\N,intron_variant,0.723,0.0635,1KG_AFR_AF,WFS1
614422,4:6293567:C>T,NM_006005.3:c.632-77C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,1.325,0.001,1KG_EAS_AF,WFS1
614423,4:6293594:C>T,NM_006005.3:c.632-50C>T,\N,\N,5/7,Unknown significance,\N,intron_variant,3.127,0.00114784,EVS_AA_AF,WFS1
614424,4:6293595:G>A,NM_006005.3:c.632-49G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,0.693,\N,\N,WFS1
614425,4:6293598:G>A,NM_006005.3:c.632-46G>A,\N,\N,5/7,Unknown significance,\N,intron_variant,4.449,0.000109409,EXAC_SAS_AF,WFS1
614426,4:6293600:G>T,NM_006005.3:c.632-44G>T,\N,\N,5/7,Unknown significance,\N,intron_variant,1.562,0.000116604,EVS_EA_AF,WFS1
614427,4:6293606:C>A,NM_006005.3:c.632-38C>A,\N,\N,5/7,Unknown significance,\N,intron_variant,5.308,0.000108108,EXAC_SAS_AF,WFS1
614428,4:6293613:TCTGA>T,NM_006005.3:c.632-27_632-24del,\N,\N,5/7,Benign,\N,intron_variant,5.676,0.017487,EXAC_EAS_AF,WFS1
614429,4:6293628:A>C,NM_006005.3:c.632-16A>C,\N,\N,5/7,Unknown significance,\N,intron_variant,4.138,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614430,4:6293630:CCT>C,NM_006005.3:c.632-13_632-12del,\N,\N,5/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614431,4:6293649:GGGGC>G,NM_006005.3:c.639_642del,NP_005996.2:p.Ala214SerfsTer72,6/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,24.5,\N,\N,WFS1
614432,4:6293650:G>A,NM_006005.3:c.638G>A,NP_005996.2:p.Gly213Glu,6/8,\N,Likely benign,\N,missense_variant,0.004,0.000771407,EXAC_AMR_AF,WFS1
614433,4:6293653:C>T,NM_006005.3:c.641C>T,NP_005996.2:p.Ala214Val,6/8,\N,Likely benign,\N,missense_variant,0.163,0.0000212621,EXAC_NFE_AF,WFS1
614434,4:6293654:G>A,NM_006005.3:c.642G>A,NP_005996.2:p.Ala214=,6/8,\N,Unknown significance,\N,synonymous_variant,7.295,0.000125313,EXAC_AMR_AF,WFS1
614435,4:6293655:C>T,NM_006005.3:c.643C>T,NP_005996.2:p.Gln215Ter,6/8,\N,Unknown significance,\N,stop_gained,36,0.00015024,EXAC_EAS_AF,WFS1
614436,4:6293659:C>G,NM_006005.3:c.647C>G,NP_005996.2:p.Pro216Arg,6/8,\N,Unknown significance,\N,missense_variant,16.4,0.00136488,EVS_AA_AF,WFS1
614437,4:6293664:C>G,NM_006005.3:c.652C>G,NP_005996.2:p.Pro218Ala,6/8,\N,Unknown significance,\N,missense_variant,17.3,0.003125,OTO_US_AF,WFS1
614438,4:6293666:C>T,NM_006005.3:c.654C>T,NP_005996.2:p.Pro218=,6/8,\N,Likely benign,\N,synonymous_variant,13.26,0.000323258,EXAC_SAS_AF,WFS1
614439,4:6293667:G>A,NM_006005.3:c.655G>A,NP_005996.2:p.Val219Met,6/8,\N,Likely benign,\N,missense_variant,20.3,0.000161108,EXAC_SAS_AF,WFS1
614440,4:6293668:T>C,NM_006005.3:c.656T>C,NP_005996.2:p.Val219Ala,6/8,\N,Likely benign,\N,missense_variant,19.13,0.000257069,EXAC_AFR_AF,WFS1
614441,4:6293672:C>T,NM_006005.3:c.660C>T,NP_005996.2:p.Pro220=,6/8,\N,Unknown significance,\N,synonymous_variant,9.82,0.0000793777,EXAC_SAS_AF,WFS1
614442,4:6293674:A>G,NM_006005.3:c.662A>G,NP_005996.2:p.Lys221Arg,6/8,\N,Likely benign,\N,missense_variant,10.53,0.000139082,EXAC_EAS_AF,WFS1
614443,4:6293678:C>T,NM_006005.3:c.666C>T,NP_005996.2:p.Ser222=,6/8,\N,Unknown significance,\N,synonymous_variant,15.57,0.0008,1KG_AFR_AF,WFS1
614444,4:6293682:C>T,NM_006005.3:c.670C>T,NP_005996.2:p.Gln224Ter,6/8,\N,Pathogenic,Wolfram syndrome,stop_gained,38,\N,\N,WFS1
614445,4:6293687:G>A,NM_006005.3:c.675G>A,NP_005996.2:p.Lys225=,6/8,\N,Unknown significance,\N,synonymous_variant,12.29,0.0000186393,EXAC_NFE_AF,WFS1
614446,4:6293688:C>T,NM_006005.3:c.676C>T,NP_005996.2:p.Gln226Ter,6/8,\N,Pathogenic,Wolfram syndrome,stop_gained,38,\N,\N,WFS1
614447,4:6293694:C>T,NM_006005.3:c.682C>T,NP_005996.2:p.Arg228Cys,6/8,\N,Unknown significance,\N,missense_variant,31,0.00010846,EXAC_AMR_AF,WFS1
614448,4:6293695:G>A,NM_006005.3:c.683G>A,NP_005996.2:p.Arg228His,6/8,\N,Pathogenic,Cerebellar ataxia,missense_variant,33,0.003125,OTO_US_AF,WFS1
614449,4:6293696:C>G,NM_006005.3:c.684C>G,NP_005996.2:p.Arg228=,6/8,\N,Benign,\N,synonymous_variant,12.77,0.936635,EXAC_EAS_AF,WFS1
614450,4:6293696:C>T,NM_006005.3:c.684C>T,NP_005996.2:p.Arg228=,6/8,\N,Unknown significance,\N,synonymous_variant,15.84,\N,\N,WFS1
614451,4:6293698:T>C,NM_006005.3:c.686T>C,NP_005996.2:p.Met229Thr,6/8,\N,Unknown significance,\N,missense_variant,12.19,0.00035014,EXAC_AMR_AF,WFS1
614452,4:6293703:G>A,NM_006005.3:c.691G>A,NP_005996.2:p.Glu231Lys,6/8,\N,Unknown significance,\N,missense_variant,27,0.00163399,EXAC_OTH_AF,WFS1
614453,4:6293704:A>G,NM_006005.3:c.692A>G,NP_005996.2:p.Glu231Gly,6/8,\N,Unknown significance,\N,missense_variant,30,0.000156887,EXAC_SAS_AF,WFS1
614454,4:6293705:G>A,NM_006005.3:c.693G>A,NP_005996.2:p.Glu231=,6/8,\N,Unknown significance,\N,synonymous_variant,10.48,0.000232666,EVS_EA_AF,WFS1
614455,4:6293706:C>T,NM_006005.3:c.694C>T,NP_005996.2:p.Arg232Cys,6/8,\N,Likely pathogenic,Cerebellar ataxia,missense_variant,25,\N,\N,WFS1
614456,4:6293707:G>A,NM_006005.3:c.695G>A,NP_005996.2:p.Arg232His,6/8,\N,Benign,\N,missense_variant,23.9,0.01,OTO_TR_AF,WFS1
614457,4:6293707:G>C,NM_006005.3:c.695G>C,NP_005996.2:p.Arg232Pro,6/8,\N,Pathogenic,Wolfram syndrome,missense_variant,26.6,\N,\N,WFS1
614458,4:6293708:C>T,NM_006005.3:c.696C>T,NP_005996.2:p.Arg232=,6/8,\N,Unknown significance,\N,synonymous_variant,16.88,0.000238284,EXAC_SAS_AF,WFS1
614459,4:6293714:C>T,NM_006005.3:c.702C>T,NP_005996.2:p.Val234=,6/8,\N,Unknown significance,\N,synonymous_variant,14.84,0.00008088,EXAC_SAS_AF,WFS1
614460,4:6293720:C>T,NM_006005.3:c.708C>T,NP_005996.2:p.Ser236=,6/8,\N,Unknown significance,\N,synonymous_variant,16.91,0.0000222549,EXAC_NFE_AF,WFS1
614461,4:6293721:G>A,NM_006005.3:c.709G>A,NP_005996.2:p.Glu237Lys,6/8,\N,Unknown significance,\N,missense_variant,32,0.0000828912,EXAC_SAS_AF,WFS1
614462,4:6293726:T>A,NM_006005.3:c.712+2T>A,\N,\N,6/7,Unknown significance,\N,splice_donor_variant,24.6,0.000179791,EXAC_EAS_AF,WFS1
614463,4:6293728:A>C,NM_006005.3:c.712+4A>C,\N,\N,6/7,Unknown significance,\N,splice_region_variant&intron_variant,12.51,0.0000238243,EXAC_NFE_AF,WFS1
614464,4:6293730:T>C,NM_006005.3:c.712+6T>C,\N,\N,6/7,Unknown significance,\N,splice_region_variant&intron_variant,13.07,0.0000877347,EXAC_SAS_AF,WFS1
614465,4:6293730:T>G,NM_006005.3:c.712+6T>G,\N,\N,6/7,Unknown significance,\N,splice_region_variant&intron_variant,14.13,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614466,4:6293732:C>T,NM_006005.3:c.712+8C>T,\N,\N,6/7,Unknown significance,\N,splice_region_variant&intron_variant,9.214,0.000642674,EXAC_AFR_AF,WFS1
614467,4:6293740:G>A,NM_006005.3:c.712+16G>A,\N,\N,6/7,Benign*,\N,intron_variant,5.328,0.00754717,EXAC_SAS_AF,WFS1
614468,4:6293742:C>G,NM_006005.3:c.712+18C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,3.904,0.0015,1KG_AFR_AF,WFS1
614469,4:6293743:C>T,NM_006005.3:c.712+19C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,4.952,0.000682749,EVS_AA_AF,WFS1
614470,4:6293744:C>T,NM_006005.3:c.712+20C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.327,0.000220653,EXAC_AMR_AF,WFS1
614471,4:6293745:G>A,NM_006005.3:c.712+21G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.166,0.000689022,EXAC_AMR_AF,WFS1
614472,4:6293762:C>A,NM_006005.3:c.712+38C>A,\N,\N,6/7,Unknown significance,\N,intron_variant,5.268,0.000491642,EXAC_AMR_AF,WFS1
614473,4:6293766:C>T,NM_006005.3:c.712+42C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,3.18,\N,\N,WFS1
614474,4:6293771:C>T,NM_006005.3:c.712+47C>T,\N,\N,6/7,Benign,\N,intron_variant,5.738,0.0074813,EXAC_EAS_AF,WFS1
614475,4:6293772:C>T,NM_006005.3:c.712+48C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.116,\N,\N,WFS1
614476,4:6293774:G>A,NM_006005.3:c.712+50G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,2.301,0.0000696476,EXAC_NFE_AF,WFS1
614477,4:6293774:G>T,NM_006005.3:c.712+50G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.063,0.000118568,EXAC_SAS_AF,WFS1
614478,4:6293780:C>T,NM_006005.3:c.712+56C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.687,\N,\N,WFS1
614479,4:6293802:T>C,NM_006005.3:c.712+78T>C,\N,\N,6/7,Benign,\N,intron_variant,3.069,0.23,1KG_AFR_AF,WFS1
614480,4:6293816:C>T,NM_006005.3:c.712+92C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,3.907,\N,\N,WFS1
614481,4:6293819:T>C,NM_006005.3:c.712+95T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,2.3,0.0015,1KG_AFR_AF,WFS1
614482,4:6293820:A>G,NM_006005.3:c.712+96A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,4.897,0.0015,1KG_AFR_AF,WFS1
614483,4:6293824:C>T,NM_006005.3:c.712+100C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,5.704,0.0008,1KG_AFR_AF,WFS1
614484,4:6293827:C>T,NM_006005.3:c.712+103C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,6.079,0.0014,1KG_AMR_AF,WFS1
614485,4:6293829:G>A,NM_006005.3:c.712+105G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,1.094,0.0023,1KG_AFR_AF,WFS1
614486,4:6293838:A>AG,NM_006005.3:c.712+115dup,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614487,4:6293838:A>G,NM_006005.3:c.712+114A>G,\N,\N,6/7,Benign,\N,intron_variant,4.797,0.9038,1KG_EAS_AF,WFS1
614488,4:6293845:G>A,NM_006005.3:c.712+121G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,2.088,0.003,1KG_AFR_AF,WFS1
614489,4:6293855:C>T,NM_006005.3:c.712+131C>T,\N,\N,6/7,Benign,\N,intron_variant,0.671,0.9038,1KG_EAS_AF,WFS1
614490,4:6293873:C>T,NM_006005.3:c.712+149C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.067,0.003,1KG_EAS_AF,WFS1
614491,4:6293887:C>A,NM_006005.3:c.712+163C>A,\N,\N,6/7,Unknown significance,\N,intron_variant,1.474,0.002,1KG_EAS_AF,WFS1
614492,4:6293888:C>T,NM_006005.3:c.712+164C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,6.1,0.001,1KG_SAS_AF,WFS1
614493,4:6293906:G>A,NM_006005.3:c.712+182G>A,\N,\N,6/7,Benign,\N,intron_variant,0.13,0.0598,1KG_AFR_AF,WFS1
614494,4:6293911:G>T,NM_006005.3:c.712+187G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.169,\N,\N,WFS1
614495,4:6293915:G>A,NM_006005.3:c.712+191G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.196,0.001,1KG_EUR_AF,WFS1
614496,4:6293916:G>A,NM_006005.3:c.712+192G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,4.649,\N,\N,WFS1
614497,4:6293919:C>G,NM_006005.3:c.712+195C>G,\N,\N,6/7,Benign,\N,intron_variant,5.147,0.9038,1KG_EAS_AF,WFS1
614498,4:6293933:C>T,NM_006005.3:c.712+209C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.543,0.001,1KG_EUR_AF,WFS1
614499,4:6293946:C>A,NM_006005.3:c.712+222C>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.967,\N,\N,WFS1
614500,4:6293962:C>T,NM_006005.3:c.712+238C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.731,0.0014,1KG_AMR_AF,WFS1
614501,4:6293966:C>T,NM_006005.3:c.712+242C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.396,\N,\N,WFS1
614502,4:6293967:G>A,NM_006005.3:c.712+243G>A,\N,\N,6/7,Benign,\N,intron_variant,0.752,0.9038,1KG_EAS_AF,WFS1
614503,4:6293989:A>G,NM_006005.3:c.712+265A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,1.883,0.0023,1KG_AFR_AF,WFS1
614504,4:6294000:C>T,NM_006005.3:c.712+276C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.773,\N,\N,WFS1
614505,4:6294001:A>G,NM_006005.3:c.712+277A>G,\N,\N,6/7,Benign,\N,intron_variant,2.538,0.9038,1KG_EAS_AF,WFS1
614506,4:6294015:C>A,NM_006005.3:c.712+291C>A,\N,\N,6/7,Unknown significance,\N,intron_variant,6.095,\N,\N,WFS1
614507,4:6294021:G>A,NM_006005.3:c.712+297G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.5,\N,\N,WFS1
614508,4:6294051:C>T,NM_006005.3:c.712+327C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.371,\N,\N,WFS1
614509,4:6294051:CG>C,NM_006005.3:c.712+334del,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614510,4:6294052:G>C,NM_006005.3:c.712+328G>C,\N,\N,6/7,Benign,\N,intron_variant,0.137,0.0091,1KG_AFR_AF,WFS1
614511,4:6294063:G>T,NM_006005.3:c.712+339G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.859,0.0008,1KG_AFR_AF,WFS1
614512,4:6294072:A>G,NM_006005.3:c.712+348A>G,\N,\N,6/7,Benign,\N,intron_variant,6.412,0.0098,1KG_AFR_AF,WFS1
614513,4:6294091:G>A,NM_006005.3:c.712+367G>A,\N,\N,6/7,Benign,\N,intron_variant,3.042,0.246,1KG_EAS_AF,WFS1
614514,4:6294095:A>G,NM_006005.3:c.712+371A>G,\N,\N,6/7,Benign,\N,intron_variant,4.141,0.9038,1KG_EAS_AF,WFS1
614515,4:6294106:G>A,NM_006005.3:c.712+382G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,2.999,\N,\N,WFS1
614516,4:6294124:G>T,NM_006005.3:c.712+400G>T,\N,\N,6/7,Benign,\N,intron_variant,1.766,0.9038,1KG_EAS_AF,WFS1
614517,4:6294125:C>G,NM_006005.3:c.712+401C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,1.701,0.0015,1KG_AFR_AF,WFS1
614518,4:6294134:A>C,NM_006005.3:c.712+410A>C,\N,\N,6/7,Benign,\N,intron_variant,1.122,0.0992,1KG_SAS_AF,WFS1
614519,4:6294139:A>AC,NM_006005.3:c.712+418dup,\N,\N,6/7,Benign,\N,intron_variant,0.32,0.0953,1KG_AFR_AF,WFS1
614520,4:6294139:A>C,NM_006005.3:c.712+415A>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.551,\N,\N,WFS1
614521,4:6294142:C>T,NM_006005.3:c.712+418C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.523,0.001,1KG_EAS_AF,WFS1
614522,4:6294173:G>A,NM_006005.3:c.712+449G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.507,0.0031,1KG_SAS_AF,WFS1
614523,4:6294181:T>A,NM_006005.3:c.712+457T>A,\N,\N,6/7,Unknown significance,\N,intron_variant,5.059,0.0015,1KG_AFR_AF,WFS1
614524,4:6294192:G>A,NM_006005.3:c.712+468G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.968,0.0031,1KG_SAS_AF,WFS1
614525,4:6294220:T>G,NM_006005.3:c.712+496T>G,\N,\N,6/7,Unknown significance,\N,intron_variant,0.779,0.0014,1KG_AMR_AF,WFS1
614526,4:6294226:GA>G,NM_006005.3:c.712+503del,\N,\N,6/7,Benign,\N,intron_variant,0.811,0.0408,1KG_AFR_AF,WFS1
614527,4:6294231:A>G,NM_006005.3:c.712+507A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,1.877,0.001,1KG_SAS_AF,WFS1
614528,4:6294251:C>T,NM_006005.3:c.712+527C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,8.735,\N,\N,WFS1
614529,4:6294266:G>C,NM_006005.3:c.712+542G>C,\N,\N,6/7,Unknown significance,\N,intron_variant,1.623,0.002,1KG_EUR_AF,WFS1
614530,4:6294267:G>A,NM_006005.3:c.712+543G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,5.683,0.001,1KG_EAS_AF,WFS1
614531,4:6294286:T>C,NM_006005.3:c.712+562T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,4.08,\N,\N,WFS1
614532,4:6294305:C>T,NM_006005.3:c.712+581C>T,\N,\N,6/7,Benign,\N,intron_variant,7.162,0.9038,1KG_EAS_AF,WFS1
614533,4:6294311:G>A,NM_006005.3:c.712+587G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,2.3,\N,\N,WFS1
614534,4:6294324:G>T,NM_006005.3:c.712+600G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.758,\N,\N,WFS1
614535,4:6294338:C>T,NM_006005.3:c.712+614C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,4.021,0.001,1KG_EAS_AF,WFS1
614536,4:6294345:G>A,NM_006005.3:c.712+621G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,1.575,\N,\N,WFS1
614537,4:6294384:G>T,NM_006005.3:c.712+660G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.693,0.001,1KG_SAS_AF,WFS1
614538,4:6294397:TAGAC>T,NM_006005.3:c.712+676_712+679del,\N,\N,6/7,Benign,\N,intron_variant,7.765,0.0265,1KG_AFR_AF,WFS1
614539,4:6294414:T>C,NM_006005.3:c.712+690T>C,\N,\N,6/7,Benign,\N,intron_variant,1.693,0.9038,1KG_EAS_AF,WFS1
614540,4:6294424:G>A,NM_006005.3:c.712+700G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,4.879,\N,\N,WFS1
614541,4:6294433:G>C,NM_006005.3:c.712+709G>C,\N,\N,6/7,Benign,\N,intron_variant,0.637,0.0307,1KG_SAS_AF,WFS1
614542,4:6294444:C>G,NM_006005.3:c.712+720C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,5.865,0.0015,1KG_AFR_AF,WFS1
614543,4:6294451:C>T,NM_006005.3:c.712+727C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,12.17,0.001,1KG_EAS_AF,WFS1
614544,4:6294473:T>C,NM_006005.3:c.712+749T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,14.19,\N,\N,WFS1
614545,4:6294479:A>G,NM_006005.3:c.712+755A>G,\N,\N,6/7,Benign,\N,intron_variant,3.432,0.0159,1KG_AFR_AF,WFS1
614546,4:6294484:C>T,NM_006005.3:c.712+760C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,6.556,0.002,1KG_EUR_AF,WFS1
614547,4:6294491:C>T,NM_006005.3:c.712+767C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.652,0.0008,1KG_AFR_AF,WFS1
614548,4:6294492:A>G,NM_006005.3:c.712+768A>G,\N,\N,6/7,Benign,\N,intron_variant,0.975,0.0159,1KG_AFR_AF,WFS1
614549,4:6294494:T>C,NM_006005.3:c.712+770T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,2.985,\N,\N,WFS1
614550,4:6294517:C>T,NM_006005.3:c.712+793C>T,\N,\N,6/7,Benign,\N,intron_variant,8.245,0.9038,1KG_EAS_AF,WFS1
614551,4:6294519:C>T,NM_006005.3:c.712+795C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,6.791,\N,\N,WFS1
614552,4:6294544:A>G,NM_006005.3:c.712+820A>G,\N,\N,6/7,Benign,\N,intron_variant,0.572,0.9038,1KG_EAS_AF,WFS1
614553,4:6294563:G>A,NM_006005.3:c.712+839G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.323,\N,\N,WFS1
614554,4:6294570:C>G,NM_006005.3:c.712+846C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,2.985,\N,\N,WFS1
614555,4:6294583:T>C,NM_006005.3:c.712+859T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,1.828,0.001,1KG_EUR_AF,WFS1
614556,4:6294607:G>A,NM_006005.3:c.712+883G>A,\N,\N,6/7,Benign,\N,intron_variant,1.755,0.9038,1KG_EAS_AF,WFS1
614557,4:6294630:A>G,NM_006005.3:c.712+906A>G,\N,\N,6/7,Benign,\N,intron_variant,0.986,0.9038,1KG_EAS_AF,WFS1
614558,4:6294650:G>A,NM_006005.3:c.712+926G>A,\N,\N,6/7,Benign,\N,intron_variant,2.108,0.0123,1KG_SAS_AF,WFS1
614559,4:6294650:G>T,NM_006005.3:c.712+926G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.062,0.002,1KG_SAS_AF,WFS1
614560,4:6294655:T>G,NM_006005.3:c.712+931T>G,\N,\N,6/7,Benign,\N,intron_variant,2.167,0.9038,1KG_EAS_AF,WFS1
614561,4:6294659:G>A,NM_006005.3:c.712+935G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.41,0.0008,1KG_AFR_AF,WFS1
614562,4:6294673:C>G,NM_006005.3:c.712+949C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,0.972,\N,\N,WFS1
614563,4:6294676:G>A,NM_006005.3:c.712+952G>A,\N,\N,6/7,Benign,\N,intron_variant,2.86,0.0756,1KG_AFR_AF,WFS1
614564,4:6294683:C>T,NM_006005.3:c.712+959C>T,\N,\N,6/7,Benign,\N,intron_variant,0.957,0.118,1KG_AFR_AF,WFS1
614565,4:6294684:G>A,NM_006005.3:c.712+960G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,5.207,\N,\N,WFS1
614566,4:6294705:C>T,NM_006005.3:c.712+981C>T,\N,\N,6/7,Benign,\N,intron_variant,1.347,0.0582,1KG_AFR_AF,WFS1
614567,4:6294717:C>T,NM_006005.3:c.712+993C>T,\N,\N,6/7,Benign,\N,intron_variant,10.92,0.005,1KG_EAS_AF,WFS1
614568,4:6294721:C>T,NM_006005.3:c.712+997C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,13.36,0.0045,1KG_AFR_AF,WFS1
614569,4:6294746:A>C,NM_006005.3:c.712+1022A>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.124,\N,\N,WFS1
614570,4:6294747:C>T,NM_006005.3:c.712+1023C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.009,\N,\N,WFS1
614571,4:6294751:A>T,NM_006005.3:c.712+1027A>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.571,\N,\N,WFS1
614572,4:6294756:G>A,NM_006005.3:c.712+1032G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,1.771,0.004,1KG_EUR_AF,WFS1
614573,4:6294759:G>A,NM_006005.3:c.712+1035G>A,\N,\N,6/7,Benign,\N,intron_variant,1.595,0.9038,1KG_EAS_AF,WFS1
614574,4:6294789:C>T,NM_006005.3:c.712+1065C>T,\N,\N,6/7,Benign,\N,intron_variant,1.081,0.0119,1KG_EUR_AF,WFS1
614575,4:6294790:G>A,NM_006005.3:c.712+1066G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.522,\N,\N,WFS1
614576,4:6294793:G>T,NM_006005.3:c.712+1069G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.621,\N,\N,WFS1
614577,4:6294801:A>C,NM_006005.3:c.712+1077A>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.372,0.0014,1KG_AMR_AF,WFS1
614578,4:6294802:G>T,NM_006005.3:c.712+1078G>T,\N,\N,6/7,Benign,\N,intron_variant,1.659,0.0197,1KG_AFR_AF,WFS1
614579,4:6294812:G>A,NM_006005.3:c.712+1088G>A,\N,\N,6/7,Benign,\N,intron_variant,1.772,0.0123,1KG_SAS_AF,WFS1
614580,4:6294824:C>T,NM_006005.3:c.712+1100C>T,\N,\N,6/7,Benign,\N,intron_variant,0.245,0.0174,1KG_SAS_AF,WFS1
614581,4:6294858:G>A,NM_006005.3:c.712+1134G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.254,\N,\N,WFS1
614582,4:6294870:A>G,NM_006005.3:c.712+1146A>G,\N,\N,6/7,Benign,\N,intron_variant,6.336,0.0151,1KG_AFR_AF,WFS1
614583,4:6294882:G>GCCTGGGTCTCCAT,NM_006005.3:c.712+1165_712+1177dup,\N,\N,6/7,Benign,\N,intron_variant,1.769,0.0091,1KG_AFR_AF,WFS1
614584,4:6294986:G>C,NM_006005.3:c.712+1262G>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.29,0.0008,1KG_AFR_AF,WFS1
614585,4:6295024:G>A,NM_006005.3:c.712+1300G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.196,0.0015,1KG_AFR_AF,WFS1
614586,4:6295046:C>T,NM_006005.3:c.712+1322C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.548,0.001,1KG_EUR_AF,WFS1
614587,4:6295063:C>T,NM_006005.3:c.712+1339C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.468,0.003,1KG_EAS_AF,WFS1
614588,4:6295064:A>G,NM_006005.3:c.712+1340A>G,\N,\N,6/7,Benign,\N,intron_variant,0.873,0.9921,1KG_EAS_AF,WFS1
614589,4:6295079:C>T,NM_006005.3:c.712+1355C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.946,\N,\N,WFS1
614590,4:6295087:T>A,NM_006005.3:c.712+1363T>A,\N,\N,6/7,Benign,\N,intron_variant,3.855,0.9038,1KG_EAS_AF,WFS1
614591,4:6295103:G>A,NM_006005.3:c.712+1379G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.272,0.0008,1KG_AFR_AF,WFS1
614592,4:6295155:A>G,NM_006005.3:c.712+1431A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,1.655,0.001,1KG_EAS_AF,WFS1
614593,4:6295164:C>T,NM_006005.3:c.712+1440C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.297,\N,\N,WFS1
614594,4:6295165:G>A,NM_006005.3:c.712+1441G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,1.117,0.001,1KG_EAS_AF,WFS1
614595,4:6295173:T>C,NM_006005.3:c.712+1449T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,2.488,0.0008,1KG_AFR_AF,WFS1
614596,4:6295177:C>G,NM_006005.3:c.712+1453C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,3.175,\N,\N,WFS1
614597,4:6295185:G>A,NM_006005.3:c.712+1461G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,1.144,0.0023,1KG_AFR_AF,WFS1
614598,4:6295191:C>T,NM_006005.3:c.712+1467C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.848,0.0015,1KG_AFR_AF,WFS1
614599,4:6295192:G>A,NM_006005.3:c.712+1468G>A,\N,\N,6/7,Benign,\N,intron_variant,0.017,0.0643,1KG_AFR_AF,WFS1
614600,4:6295208:C>G,NM_006005.3:c.712+1484C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,2.794,0.004,1KG_EAS_AF,WFS1
614601,4:6295208:C>T,NM_006005.3:c.712+1484C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,4.41,\N,\N,WFS1
614602,4:6295209:C>T,NM_006005.3:c.712+1485C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,3.394,\N,\N,WFS1
614603,4:6295217:T>C,NM_006005.3:c.712+1493T>C,\N,\N,6/7,Benign,\N,intron_variant,0.701,0.9038,1KG_EAS_AF,WFS1
614604,4:6295233:C>T,NM_006005.3:c.712+1509C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.316,\N,\N,WFS1
614605,4:6295238:C>T,NM_006005.3:c.712+1514C>T,\N,\N,6/7,Benign,\N,intron_variant,1.984,0.0227,1KG_AFR_AF,WFS1
614606,4:6295255:AC>A,NM_006005.3:c.713-1507del,\N,\N,6/7,Benign,\N,intron_variant,1.056,0.996,1KG_EAS_AF,WFS1
614607,4:6295261:C>T,NM_006005.3:c.713-1507C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.903,\N,\N,WFS1
614608,4:6295269:G>A,NM_006005.3:c.713-1499G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,1.703,0.003,1KG_EUR_AF,WFS1
614609,4:6295284:T>C,NM_006005.3:c.713-1484T>C,\N,\N,6/7,Benign,\N,intron_variant,1.051,0.0123,1KG_SAS_AF,WFS1
614610,4:6295317:G>A,NM_006005.3:c.713-1451G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.183,0.001,1KG_SAS_AF,WFS1
614611,4:6295319:T>C,NM_006005.3:c.713-1449T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.627,0.001,1KG_SAS_AF,WFS1
614612,4:6295320:G>T,NM_006005.3:c.713-1448G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.274,0.001,1KG_SAS_AF,WFS1
614613,4:6295322:C>G,NM_006005.3:c.713-1446C>G,\N,\N,6/7,Benign,\N,intron_variant,2.726,0.9048,1KG_EAS_AF,WFS1
614614,4:6295350:C>A,NM_006005.3:c.713-1418C>A,\N,\N,6/7,Benign,\N,intron_variant,0.014,0.0159,1KG_AFR_AF,WFS1
614615,4:6295360:G>A,NM_006005.3:c.713-1408G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.709,\N,\N,WFS1
614616,4:6295378:C>G,NM_006005.3:c.713-1390C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,1.714,0.002,1KG_EAS_AF,WFS1
614617,4:6295378:C>T,NM_006005.3:c.713-1390C>T,\N,\N,6/7,Benign,\N,intron_variant,2.554,0.0447,1KG_AMR_AF,WFS1
614618,4:6295390:T>C,NM_006005.3:c.713-1378T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.612,0.004,1KG_EAS_AF,WFS1
614619,4:6295392:T>C,NM_006005.3:c.713-1376T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,1.229,0.002,1KG_EUR_AF,WFS1
614620,4:6295408:G>A,NM_006005.3:c.713-1360G>A,\N,\N,6/7,Benign,\N,intron_variant,0.036,0.085,1KG_AMR_AF,WFS1
614621,4:6295425:G>A,NM_006005.3:c.713-1343G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.05,0.001,1KG_EAS_AF,WFS1
614622,4:6295427:C>G,NM_006005.3:c.713-1341C>G,\N,\N,6/7,Benign,\N,intron_variant,1.754,0.9038,1KG_EAS_AF,WFS1
614623,4:6295428:A>G,NM_006005.3:c.713-1340A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,0.6,\N,\N,WFS1
614624,4:6295441:CA>C,NM_006005.3:c.713-1325del,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614625,4:6295451:A>G,NM_006005.3:c.713-1317A>G,\N,\N,6/7,Benign,\N,intron_variant,0.777,0.9038,1KG_EAS_AF,WFS1
614626,4:6295457:A>G,NM_006005.3:c.713-1311A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,0.721,\N,\N,WFS1
614627,4:6295486:C>G,NM_006005.3:c.713-1282C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,3.319,\N,\N,WFS1
614628,4:6295517:A>G,NM_006005.3:c.713-1251A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,3.203,0.001,1KG_EAS_AF,WFS1
614629,4:6295525:G>C,NM_006005.3:c.713-1243G>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.424,0.001,1KG_EUR_AF,WFS1
614630,4:6295549:C>T,NM_006005.3:c.713-1219C>T,\N,\N,6/7,Benign,\N,intron_variant,2.896,0.0873,1KG_EAS_AF,WFS1
614631,4:6295551:C>CA,NM_006005.3:c.713-1217_713-1216insA,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614632,4:6295551:C>T,NM_006005.3:c.713-1217C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.315,0.0014,1KG_AMR_AF,WFS1
614633,4:6295562:C>T,NM_006005.3:c.713-1206C>T,\N,\N,6/7,Benign,\N,intron_variant,0.738,0.0242,1KG_AFR_AF,WFS1
614634,4:6295565:C>T,NM_006005.3:c.713-1203C>T,\N,\N,6/7,Benign,\N,intron_variant,1.681,0.8978,1KG_EAS_AF,WFS1
614635,4:6295577:G>A,NM_006005.3:c.713-1191G>A,\N,\N,6/7,Benign,\N,intron_variant,0.42,0.0053,1KG_AFR_AF,WFS1
614636,4:6295583:C>A,NM_006005.3:c.713-1185C>A,\N,\N,6/7,Benign,\N,intron_variant,0.093,0.9038,1KG_EAS_AF,WFS1
614637,4:6295591:C>T,NM_006005.3:c.713-1177C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.432,0.001,1KG_EAS_AF,WFS1
614638,4:6295598:G>A,NM_006005.3:c.713-1170G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,4.451,0.0015,1KG_AFR_AF,WFS1
614639,4:6295608:G>A,NM_006005.3:c.713-1160G>A,\N,\N,6/7,Benign,\N,intron_variant,2.411,0.006,1KG_EAS_AF,WFS1
614640,4:6295612:G>A,NM_006005.3:c.713-1156G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.734,\N,\N,WFS1
614641,4:6295693:C>G,NM_006005.3:c.713-1075C>G,\N,\N,6/7,Benign*,\N,intron_variant,3.055,0.9018,1KG_EAS_AF,WFS1
614642,4:6295695:A>C,NM_006005.3:c.713-1073A>C,\N,\N,6/7,Unknown significance,\N,intron_variant,4.233,\N,\N,WFS1
614643,4:6295697:C>A,NM_006005.3:c.713-1071C>A,\N,\N,6/7,Unknown significance,\N,intron_variant,4.998,\N,\N,WFS1
614644,4:6295709:T>C,NM_006005.3:c.713-1059T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.997,0.002,1KG_SAS_AF,WFS1
614645,4:6295717:C>A,NM_006005.3:c.713-1051C>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.837,\N,\N,WFS1
614646,4:6295719:C>G,NM_006005.3:c.713-1049C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,6.714,\N,\N,WFS1
614647,4:6295731:A>ATC,NM_006005.3:c.713-1033_713-1032dup,\N,\N,6/7,Benign,\N,intron_variant,6.168,0.2587,1KG_AFR_AF,WFS1
614648,4:6295736:T>TC,NM_006005.3:c.713-1032_713-1031insC,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614649,4:6295744:A>T,NM_006005.3:c.713-1024A>T,\N,\N,6/7,Benign,\N,intron_variant,0.009,0.2572,1KG_AFR_AF,WFS1
614650,4:6295750:A>G,NM_006005.3:c.713-1018A>G,\N,\N,6/7,Benign,\N,intron_variant,1.37,0.8204,1KG_EAS_AF,WFS1
614651,4:6295764:C>G,NM_006005.3:c.713-1004C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,0.72,0.002,1KG_SAS_AF,WFS1
614652,4:6295770:C>T,NM_006005.3:c.713-998C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,4.191,0.001,1KG_EAS_AF,WFS1
614653,4:6295775:C>T,NM_006005.3:c.713-993C>T,\N,\N,6/7,Benign,\N,intron_variant,0.671,0.2368,1KG_AFR_AF,WFS1
614654,4:6295808:C>G,NM_006005.3:c.713-960C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,2.63,\N,\N,WFS1
614655,4:6295816:G>A,NM_006005.3:c.713-952G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.856,0.0008,1KG_AFR_AF,WFS1
614656,4:6295823:A>G,NM_006005.3:c.713-945A>G,\N,\N,6/7,Benign,\N,intron_variant,2.895,0.1002,1KG_SAS_AF,WFS1
614657,4:6295846:A>T,NM_006005.3:c.713-922A>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.885,\N,\N,WFS1
614658,4:6295853:C>T,NM_006005.3:c.713-915C>T,\N,\N,6/7,Benign,\N,intron_variant,2.081,0.2542,1KG_AFR_AF,WFS1
614659,4:6295874:G>T,NM_006005.3:c.713-894G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,5.185,0.0014,1KG_AMR_AF,WFS1
614660,4:6295875:C>T,NM_006005.3:c.713-893C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,7.27,0.0014,1KG_AMR_AF,WFS1
614661,4:6295888:C>T,NM_006005.3:c.713-880C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.835,0.002,1KG_EUR_AF,WFS1
614662,4:6295925:C>T,NM_006005.3:c.713-843C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,2.778,\N,\N,WFS1
614663,4:6295935:C>G,NM_006005.3:c.713-833C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,0.284,0.002,1KG_EAS_AF,WFS1
614664,4:6295948:T>G,NM_006005.3:c.713-820T>G,\N,\N,6/7,Unknown significance,\N,intron_variant,1.57,0.0031,1KG_SAS_AF,WFS1
614665,4:6295962:C>G,NM_006005.3:c.713-806C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,1.257,\N,\N,WFS1
614666,4:6295966:G>A,NM_006005.3:c.713-802G>A,\N,\N,6/7,Benign,\N,intron_variant,2.512,0.0083,1KG_AFR_AF,WFS1
614667,4:6295971:C>G,NM_006005.3:c.713-797C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,2.227,\N,\N,WFS1
614668,4:6295982:C>T,NM_006005.3:c.713-786C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,6.099,0.003,1KG_AFR_AF,WFS1
614669,4:6295985:G>A,NM_006005.3:c.713-783G>A,\N,\N,6/7,Benign,\N,intron_variant,6.074,0.9663,1KG_EAS_AF,WFS1
614670,4:6296019:A>G,NM_006005.3:c.713-749A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,1.048,0.001,1KG_SAS_AF,WFS1
614671,4:6296024:G>C,NM_006005.3:c.713-744G>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.276,\N,\N,WFS1
614672,4:6296029:G>T,NM_006005.3:c.713-739G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.323,\N,\N,WFS1
614673,4:6296037:G>A,NM_006005.3:c.713-731G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.636,0.001,1KG_EAS_AF,WFS1
614674,4:6296054:C>T,NM_006005.3:c.713-714C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.306,0.0014,1KG_AMR_AF,WFS1
614675,4:6296103:G>A,NM_006005.3:c.713-665G>A,\N,\N,6/7,Benign,\N,intron_variant,6.514,0.0112,1KG_SAS_AF,WFS1
614676,4:6296110:G>A,NM_006005.3:c.713-658G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,7.258,0.001,1KG_SAS_AF,WFS1
614677,4:6296114:G>A,NM_006005.3:c.713-654G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,7.627,0.001,1KG_SAS_AF,WFS1
614678,4:6296116:G>A,NM_006005.3:c.713-652G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,6.568,0.003,1KG_EUR_AF,WFS1
614679,4:6296122:C>T,NM_006005.3:c.713-646C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,5.928,0.0014,1KG_AMR_AF,WFS1
614680,4:6296137:C>T,NM_006005.3:c.713-631C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.927,\N,\N,WFS1
614681,4:6296138:G>T,NM_006005.3:c.713-630G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.664,\N,\N,WFS1
614682,4:6296140:A>G,NM_006005.3:c.713-628A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,0.064,0.001,1KG_SAS_AF,WFS1
614683,4:6296151:A>G,NM_006005.3:c.713-617A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,3.493,0.0008,1KG_AFR_AF,WFS1
614684,4:6296162:G>A,NM_006005.3:c.713-606G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.549,\N,\N,WFS1
614685,4:6296174:G>A,NM_006005.3:c.713-594G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,4.07,\N,\N,WFS1
614686,4:6296202:G>A,NM_006005.3:c.713-566G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.906,0.001,1KG_EUR_AF,WFS1
614687,4:6296205:TC>T,NM_006005.3:c.713-562del,\N,\N,6/7,Unknown significance,\N,intron_variant,0.22,\N,\N,WFS1
614688,4:6296206:C>CA,NM_006005.3:c.713-561dup,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614689,4:6296206:C>T,NM_006005.3:c.713-562C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.656,\N,\N,WFS1
614690,4:6296206:CA>C,NM_006005.3:c.713-561del,\N,\N,6/7,Benign,\N,intron_variant,5.694,0.9038,1KG_EAS_AF,WFS1
614691,4:6296207:A>G,NM_006005.3:c.713-561A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,3.394,\N,\N,WFS1
614692,4:6296208:G>C,NM_006005.3:c.713-560G>C,\N,\N,6/7,Unknown significance,\N,intron_variant,1.176,\N,\N,WFS1
614693,4:6296216:AT>A,NM_006005.3:c.713-551del,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614694,4:6296216:ATAG>A,NM_006005.3:c.713-548_713-546del,\N,\N,6/7,Benign,\N,intron_variant,6.669,0.1312,1KG_EUR_AF,WFS1
614695,4:6296217:TA>T,NM_006005.3:c.713-550del,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614696,4:6296218:AG>A,NM_006005.3:c.713-549del,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614697,4:6296219:GTA>G,NM_006005.3:c.713-548_713-547del,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614698,4:6296229:G>A,NM_006005.3:c.713-539G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.441,\N,\N,WFS1
614699,4:6296244:A>C,NM_006005.3:c.713-524A>C,\N,\N,6/7,Unknown significance,\N,intron_variant,1.553,0.0015,1KG_AFR_AF,WFS1
614700,4:6296250:C>T,NM_006005.3:c.713-518C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,5.255,\N,\N,WFS1
614701,4:6296251:G>A,NM_006005.3:c.713-517G>A,\N,\N,6/7,Benign,\N,intron_variant,7.262,0.005,1KG_EAS_AF,WFS1
614702,4:6296271:G>A,NM_006005.3:c.713-497G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,10.58,0.0014,1KG_AMR_AF,WFS1
614703,4:6296287:C>T,NM_006005.3:c.713-481C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.653,\N,\N,WFS1
614704,4:6296288:G>A,NM_006005.3:c.713-480G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,2.078,\N,\N,WFS1
614705,4:6296293:A>C,NM_006005.3:c.713-475A>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.77,0.001,1KG_EAS_AF,WFS1
614706,4:6296299:G>A,NM_006005.3:c.713-469G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,10.81,0.001,1KG_EAS_AF,WFS1
614707,4:6296310:G>A,NM_006005.3:c.713-458G>A,\N,\N,6/7,Benign,\N,intron_variant,4.217,0.0123,1KG_SAS_AF,WFS1
614708,4:6296310:GCA>ACT,NM_006005.3:c.713-458_713-456delinsACT,\N,\N,6/7,Unknown significance,\N,intron_variant,5.651,\N,\N,WFS1
614709,4:6296312:A>T,NM_006005.3:c.713-456A>T,\N,\N,6/7,Benign,\N,intron_variant,6.574,0.0123,1KG_SAS_AF,WFS1
614710,4:6296321:TC>T,NM_006005.3:c.713-446del,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614711,4:6296325:T>C,NM_006005.3:c.713-443T>C,\N,\N,6/7,Benign,\N,intron_variant,4.277,0.0644,1KG_SAS_AF,WFS1
614712,4:6296330:C>T,NM_006005.3:c.713-438C>T,\N,\N,6/7,Benign,\N,intron_variant,0.136,0.005,1KG_EAS_AF,WFS1
614713,4:6296330:CG>C,NM_006005.3:c.713-436del,\N,\N,6/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614714,4:6296341:G>C,NM_006005.3:c.713-427G>C,\N,\N,6/7,Unknown significance,\N,intron_variant,0.337,0.001,1KG_EUR_AF,WFS1
614715,4:6296343:A>G,NM_006005.3:c.713-425A>G,\N,\N,6/7,Benign,\N,intron_variant,4.307,0.9038,1KG_EAS_AF,WFS1
614716,4:6296357:C>T,NM_006005.3:c.713-411C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,5.179,0.001,1KG_EAS_AF|1KG_EUR_AF,WFS1
614717,4:6296369:C>T,NM_006005.3:c.713-399C>T,\N,\N,6/7,Benign,\N,intron_variant,0.545,0.0537,1KG_AFR_AF,WFS1
614718,4:6296370:G>T,NM_006005.3:c.713-398G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.775,0.0008,1KG_AFR_AF,WFS1
614719,4:6296388:C>T,NM_006005.3:c.713-380C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.368,0.001,1KG_SAS_AF,WFS1
614720,4:6296389:G>A,NM_006005.3:c.713-379G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.136,\N,\N,WFS1
614721,4:6296398:AGAG>A,NM_006005.3:c.713-365_713-363del,\N,\N,6/7,Benign,\N,intron_variant,6.003,0.0136,1KG_AFR_AF,WFS1
614722,4:6296417:C>T,NM_006005.3:c.713-351C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.99,0.0008,1KG_AFR_AF,WFS1
614723,4:6296426:T>A,NM_006005.3:c.713-342T>A,\N,\N,6/7,Unknown significance,\N,intron_variant,6.229,\N,\N,WFS1
614724,4:6296432:T>G,NM_006005.3:c.713-336T>G,\N,\N,6/7,Unknown significance,\N,intron_variant,2.353,0.001,1KG_SAS_AF,WFS1
614725,4:6296442:T>C,NM_006005.3:c.713-326T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,1.83,0.0023,1KG_AFR_AF,WFS1
614726,4:6296447:G>T,NM_006005.3:c.713-321G>T,\N,\N,6/7,Benign,\N,intron_variant,1.615,0.1875,1KG_EAS_AF,WFS1
614727,4:6296454:T>C,NM_006005.3:c.713-314T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,3.207,0.001,1KG_EUR_AF,WFS1
614728,4:6296477:G>A,NM_006005.3:c.713-291G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,3.743,0.001,1KG_SAS_AF,WFS1
614729,4:6296490:G>T,NM_006005.3:c.713-278G>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.583,0.001,1KG_EAS_AF,WFS1
614730,4:6296516:G>C,NM_006005.3:c.713-252G>C,\N,\N,6/7,Unknown significance,\N,intron_variant,1.822,0.0008,1KG_AFR_AF,WFS1
614731,4:6296520:G>A,NM_006005.3:c.713-248G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,7.584,0.001,1KG_EUR_AF,WFS1
614732,4:6296537:G>A,NM_006005.3:c.713-231G>A,\N,\N,6/7,Benign,\N,intron_variant,3.882,0.0133,1KG_SAS_AF,WFS1
614733,4:6296541:C>T,NM_006005.3:c.713-227C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.992,0.001,1KG_EAS_AF,WFS1
614734,4:6296542:G>A,NM_006005.3:c.713-226G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,2.63,0.001,1KG_EAS_AF,WFS1
614735,4:6296570:G>A,NM_006005.3:c.713-198G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,4.658,0.0008,1KG_AFR_AF,WFS1
614736,4:6296620:C>T,NM_006005.3:c.713-148C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.454,0.002,1KG_EUR_AF,WFS1
614737,4:6296621:G>A,NM_006005.3:c.713-147G>A,\N,\N,6/7,Benign,\N,intron_variant,0.775,0.0456,1KG_EAS_AF,WFS1
614738,4:6296628:G>A,NM_006005.3:c.713-140G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,4.326,\N,\N,WFS1
614739,4:6296657:G>C,NM_006005.3:c.713-111G>C,\N,\N,6/7,Unknown significance,\N,intron_variant,4.382,0.0008,1KG_AFR_AF,WFS1
614740,4:6296660:CCTTT>C,NM_006005.3:c.713-104_713-101del,\N,\N,6/7,Benign,\N,intron_variant,7.406,0.0123,1KG_SAS_AF,WFS1
614741,4:6296670:C>T,NM_006005.3:c.713-98C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,4.109,\N,\N,WFS1
614742,4:6296681:G>A,NM_006005.3:c.713-87G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,1.415,0.004,1KG_EUR_AF,WFS1
614743,4:6296686:C>G,NM_006005.3:c.713-82C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,0.897,0.0000156676,EXAC_NFE_AF,WFS1
614744,4:6296686:C>T,NM_006005.3:c.713-82C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,1.729,0.001,1KG_EAS_AF,WFS1
614745,4:6296687:G>A,NM_006005.3:c.713-81G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.347,0.000215378,EXAC_AFR_AF,WFS1
614746,4:6296689:C>A,NM_006005.3:c.713-79C>A,\N,\N,6/7,Benign,\N,intron_variant,7.084,0.0079,1KG_EAS_AF,WFS1
614747,4:6296699:T>C,NM_006005.3:c.713-69T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,1.32,0.0000155885,EXAC_NFE_AF,WFS1
614748,4:6296701:G>A,NM_006005.3:c.713-67G>A,\N,\N,6/7,Benign,\N,intron_variant,1.039,0.0051609,EXAC_SAS_AF,WFS1
614749,4:6296702:C>T,NM_006005.3:c.713-66C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,3.061,0.00010553,EXAC_AFR_AF,WFS1
614750,4:6296706:G>GT,NM_006005.3:c.713-61dup,\N,\N,6/7,Unknown significance,\N,intron_variant,1.997,0.0000867453,EXAC_AMR_AF,WFS1
614751,4:6296710:G>A,NM_006005.3:c.713-58G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,0.306,0.0000867303,EXAC_AMR_AF,WFS1
614752,4:6296723:G>A,NM_006005.3:c.713-45G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,4.179,0.0000154112,EXAC_NFE_AF,WFS1
614753,4:6296723:G>C,NM_006005.3:c.713-45G>C,\N,\N,6/7,Unknown significance,\N,intron_variant,1.261,\N,\N,WFS1
614754,4:6296728:G>GC,NM_006005.3:c.713-39dup,\N,\N,6/7,Unknown significance,\N,intron_variant,2.543,0.0000606575,EXAC_SAS_AF,WFS1
614755,4:6296729:C>T,NM_006005.3:c.713-39C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,4.107,0.0000307352,EXAC_NFE_AF,WFS1
614756,4:6296739:C>G,NM_006005.3:c.713-29C>G,\N,\N,6/7,Unknown significance,\N,intron_variant,0.392,0.0000152695,EXAC_NFE_AF,WFS1
614757,4:6296739:C>T,NM_006005.3:c.713-29C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,0.894,0.0000152695,EXAC_NFE_AF,WFS1
614758,4:6296740:G>A,NM_006005.3:c.713-28G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,2.124,0.0000981932,EXAC_AFR_AF,WFS1
614759,4:6296742:C>T,NM_006005.3:c.713-26C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,7.465,0.000121227,EXAC_SAS_AF,WFS1
614760,4:6296743:C>T,NM_006005.3:c.713-25C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,8.041,0.000432676,EXAC_AMR_AF,WFS1
614761,4:6296744:A>G,NM_006005.3:c.713-24A>G,\N,\N,6/7,Unknown significance,\N,intron_variant,7.296,0.000116279,EVS_EA_AF,WFS1
614762,4:6296749:G>A,NM_006005.3:c.713-19G>A,\N,\N,6/7,Unknown significance,\N,intron_variant,7.312,0.0000865052,EXAC_AMR_AF,WFS1
614763,4:6296755:T>C,NM_006005.3:c.713-13T>C,\N,\N,6/7,Unknown significance,\N,intron_variant,11.64,0.000116036,EXAC_EAS_AF,WFS1
614764,4:6296758:C>T,NM_006005.3:c.713-10C>T,\N,\N,6/7,Unknown significance,\N,intron_variant,11.43,0.000097012,EXAC_AFR_AF,WFS1
614765,4:6296759:A>T,NM_006005.3:c.713-9A>T,\N,\N,6/7,Unknown significance,\N,intron_variant,10.2,0.002,1KG_SAS_AF,WFS1
614766,4:6296761:G>A,NM_006005.3:c.713-7G>A,\N,\N,6/7,Unknown significance,\N,splice_region_variant&intron_variant,9.896,\N,\N,WFS1
614767,4:6296771:A>G,NM_006005.3:c.716A>G,NP_005996.2:p.Lys239Arg,7/8,\N,Unknown significance,\N,missense_variant,23.2,\N,\N,WFS1
614768,4:6296778:C>T,NM_006005.3:c.723C>T,NP_005996.2:p.Tyr241=,7/8,\N,Unknown significance,\N,synonymous_variant,1.894,0.0000968429,EXAC_AFR_AF,WFS1
614769,4:6296779:A>G,NM_006005.3:c.724A>G,NP_005996.2:p.Ile242Val,7/8,\N,Likely benign,\N,missense_variant,0.005,\N,\N,WFS1
614770,4:6296781:C>T,NM_006005.3:c.726C>T,NP_005996.2:p.Ile242=,7/8,\N,Unknown significance,\N,synonymous_variant,11.96,0.000121153,EXAC_SAS_AF,WFS1
614771,4:6296782:G>A,NM_006005.3:c.727G>A,NP_005996.2:p.Ala243Thr,7/8,\N,Likely benign,\N,missense_variant,8.419,0.000015124,EXAC_NFE_AF,WFS1
614772,4:6296783:C>T,NM_006005.3:c.728C>T,NP_005996.2:p.Ala243Val,7/8,\N,Likely pathogenic,Cerebellar ataxia,missense_variant,23.2,0.00102993,EXAC_SAS_AF,WFS1
614773,4:6296784:G>A,NM_006005.3:c.729G>A,NP_005996.2:p.Ala243=,7/8,\N,Unknown significance,\N,synonymous_variant,4.663,0.000115955,EXAC_EAS_AF,WFS1
614774,4:6296787:G>A,NM_006005.3:c.732G>A,NP_005996.2:p.Leu244=,7/8,\N,Unknown significance,\N,synonymous_variant,2.963,\N,\N,WFS1
614775,4:6296790:T>C,NM_006005.3:c.735T>C,NP_005996.2:p.Asp245=,7/8,\N,Unknown significance,\N,synonymous_variant,0.025,0.0000302425,EXAC_NFE_AF,WFS1
614776,4:6296792:A>G,NM_006005.3:c.737A>G,NP_005996.2:p.Asp246Gly,7/8,\N,Unknown significance,\N,missense_variant,23.9,0.000115955,EXAC_EAS_AF,WFS1
614777,4:6296793:CT>C,NM_006005.3:c.741del,NP_005996.2:p.Phe247LeufsTer40,7/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,\N,\N,\N,WFS1
614778,4:6296793:CTT>C,NM_006005.3:c.740_741del,NP_005996.2:p.Phe247CysfsTer5,7/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,28.9,\N,\N,WFS1
614779,4:6296798:T>G,NM_006005.3:c.743T>G,NP_005996.2:p.Val248Gly,7/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.4,\N,\N,WFS1
614780,4:6296802:G>A,NM_006005.3:c.747G>A,NP_005996.2:p.Glu249=,7/8,\N,Unknown significance,\N,synonymous_variant,8.677,0.0000864454,EXAC_AMR_AF,WFS1
614781,4:6296806:A>C,NM_006005.3:c.751A>C,NP_005996.2:p.Thr251Pro,7/8,\N,Unknown significance,\N,missense_variant,24.6,0.0000302499,EXAC_NFE_AF,WFS1
614782,4:6296817:C>T,NM_006005.3:c.762C>T,NP_005996.2:p.Tyr254=,7/8,\N,Likely benign,\N,synonymous_variant,6.916,0.00136178,EVS_AA_AF,WFS1
614783,4:6296826:C>T,NM_006005.3:c.771C>T,NP_005996.2:p.Gly257=,7/8,\N,Unknown significance,\N,synonymous_variant,16.93,0.000060562,EXAC_SAS_AF,WFS1
614784,4:6296827:G>A,NM_006005.3:c.772G>A,NP_005996.2:p.Val258Ile,7/8,\N,Likely benign,\N,missense_variant,3.268,0.00173933,EXAC_EAS_AF,WFS1
614785,4:6296828:T>C,NM_006005.3:c.773T>C,NP_005996.2:p.Val258Ala,7/8,\N,Unknown significance,\N,missense_variant,14.66,0.0000967867,EXAC_AFR_AF,WFS1
614786,4:6296828:T>TC,NM_006005.3:c.774dup,NP_005996.2:p.Ile259HisfsTer13,7/8,\N,Unknown significance,\N,frameshift_variant,32,0.0000151382,EXAC_NFE_AF,WFS1
614787,4:6296835:C>T,NM_006005.3:c.780C>T,NP_005996.2:p.Pro260=,7/8,\N,Unknown significance,\N,synonymous_variant,12.87,0.0000151405,EXAC_NFE_AF,WFS1
614788,4:6296837:G>C,NM_006005.3:c.782G>C,NP_005996.2:p.Ser261Thr,7/8,\N,Likely benign,\N,missense_variant,0.045,0.000060562,EXAC_SAS_AF,WFS1
614789,4:6296838:C>A,NM_006005.3:c.783C>A,NP_005996.2:p.Ser261Arg,7/8,\N,Likely benign,\N,missense_variant,16.08,0.000060562,EXAC_SAS_AF,WFS1
614790,4:6296842:C>T,NM_006005.3:c.787C>T,NP_005996.2:p.Leu263=,7/8,\N,Unknown significance,\N,synonymous_variant,13.78,0.000345901,EXAC_AMR_AF,WFS1
614791,4:6296844:G>A,NM_006005.3:c.789G>A,NP_005996.2:p.Leu263=,7/8,\N,Unknown significance,\N,synonymous_variant,10.02,0.0000151529,EXAC_NFE_AF,WFS1
614792,4:6296846:T>C,NM_006005.3:c.791T>C,NP_005996.2:p.Phe264Ser,7/8,\N,Likely benign,\N,missense_variant,13.78,0.0000151538,EXAC_NFE_AF,WFS1
614793,4:6296847:C>G,NM_006005.3:c.792C>G,NP_005996.2:p.Phe264Leu,7/8,\N,Likely benign,\N,missense_variant,10.32,0.000453926,EVS_AA_AF,WFS1
614794,4:6296851:C>T,NM_006005.3:c.796C>T,NP_005996.2:p.Gln266Ter,7/8,\N,Pathogenic,Wolfram syndrome,stop_gained,36,\N,\N,WFS1
614795,4:6296852:A>G,NM_006005.3:c.797A>G,NP_005996.2:p.Gln266Arg,7/8,\N,Likely benign,\N,missense_variant,12.03,0.000116171,EXAC_EAS_AF,WFS1
614796,4:6296853:GGAC>G,NM_006005.3:c.804_806del,NP_005996.2:p.Asp268del,7/8,\N,Unknown significance,\N,inframe_deletion,15.73,0.000060562,EXAC_SAS_AF,WFS1
614797,4:6296854:G>A,NM_006005.3:c.799G>A,NP_005996.2:p.Asp267Asn,7/8,\N,Likely benign,\N,missense_variant,24.1,0.000697674,EVS_EA_AF,WFS1
614798,4:6296856:C>G,NM_006005.3:c.801C>G,NP_005996.2:p.Asp267Glu,7/8,\N,Likely benign,\N,missense_variant,0.312,0.0000605767,EXAC_SAS_AF,WFS1
614799,4:6296856:C>T,NM_006005.3:c.801C>T,NP_005996.2:p.Asp267=,7/8,\N,Unknown significance,\N,synonymous_variant,15.42,0.0015,1KG_AFR_AF,WFS1
614800,4:6296857:G>T,NM_006005.3:c.802G>T,NP_005996.2:p.Asp268Tyr,7/8,\N,Unknown significance,\N,missense_variant,27.7,0.0000864902,EXAC_AMR_AF,WFS1
614801,4:6296858:A>G,NM_006005.3:c.803A>G,NP_005996.2:p.Asp268Gly,7/8,\N,Unknown significance,\N,missense_variant,15.14,0.000015174,EXAC_NFE_AF,WFS1
614802,4:6296859:C>T,NM_006005.3:c.804C>T,NP_005996.2:p.Asp268=,7/8,\N,Unknown significance,\N,synonymous_variant,15.93,0.001,1KG_EAS_AF,WFS1
614803,4:6296860:G>A,NM_006005.3:c.805G>A,NP_005996.2:p.Glu269Lys,7/8,\N,Unknown significance,\N,missense_variant,16.7,0.000453926,EVS_AA_AF,WFS1
614804,4:6296862:A>T,NM_006005.3:c.807A>T,NP_005996.2:p.Glu269Asp,7/8,\N,Likely benign,\N,missense_variant,2.737,0.000015187,EXAC_NFE_AF,WFS1
614805,4:6296868:T>C,NM_006005.3:c.813T>C,NP_005996.2:p.Asp271=,7/8,\N,Unknown significance,\N,synonymous_variant,0.015,0.0000152073,EXAC_NFE_AF,WFS1
614806,4:6296871:C>T,NM_006005.3:c.816C>T,NP_005996.2:p.Asp272=,7/8,\N,Unknown significance,\N,synonymous_variant,17.27,0.000242307,EXAC_SAS_AF,WFS1
614807,4:6296872:G>A,NM_006005.3:c.817G>A,NP_005996.2:p.Glu273Lys,7/8,\N,Unknown significance,\N,missense_variant,34,0.00190443,EXAC_AMR_AF,WFS1
614808,4:6296872:G>T,NM_006005.3:c.817G>T,NP_005996.2:p.Glu273Ter,7/8,\N,Pathogenic,Wolfram syndrome,stop_gained,40,0.00001523,EXAC_NFE_AF,WFS1
614809,4:6296873:A>C,NM_006005.3:c.818A>C,NP_005996.2:p.Glu273Ala,7/8,\N,Unknown significance,\N,missense_variant,24.9,0.001,1KG_EAS_AF,WFS1
614810,4:6296879:C>G,NM_006005.3:c.824C>G,NP_005996.2:p.Ala275Gly,7/8,\N,Likely benign,\N,missense_variant,24.3,0.0000974849,EXAC_AFR_AF,WFS1
614811,4:6296879:C>T,NM_006005.3:c.824C>T,NP_005996.2:p.Ala275Val,7/8,\N,Likely benign,\N,missense_variant,22.5,0.0000305465,EXAC_NFE_AF,WFS1
614812,4:6296880:G>A,NM_006005.3:c.825G>A,NP_005996.2:p.Ala275=,7/8,\N,Likely benign,\N,synonymous_variant,14.14,0.0008,1KG_AFR_AF,WFS1
614813,4:6296883:G>A,NM_006005.3:c.828G>A,NP_005996.2:p.Gly276=,7/8,\N,Unknown significance,\N,synonymous_variant,11.27,0.0000305988,EXAC_NFE_AF,WFS1
614814,4:6296884:A>G,NM_006005.3:c.829A>G,NP_005996.2:p.Lys277Glu,7/8,\N,Unknown significance,\N,missense_variant,23.7,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614815,4:6296885:A>G,NM_006005.3:c.830A>G,NP_005996.2:p.Lys277Arg,7/8,\N,Likely benign,\N,missense_variant,15.89,0.0000306016,EXAC_NFE_AF,WFS1
614816,4:6296886:G>A,NM_006005.3:c.831G>A,NP_005996.2:p.Lys277=,7/8,\N,Unknown significance,\N,synonymous_variant,13.85,0.0041,1KG_SAS_AF,WFS1
614817,4:6296889:C>A,NM_006005.3:c.834C>A,NP_005996.2:p.Ser278Arg,7/8,\N,Likely benign,\N,missense_variant,22.8,0.000015361,EXAC_NFE_AF,WFS1
614818,4:6296891:C>T,NM_006005.3:c.836C>T,NP_005996.2:p.Pro279Leu,7/8,\N,Unknown significance,\N,missense_variant,24,\N,\N,WFS1
614819,4:6296891:C>A,NM_006005.3:c.836C>A,NP_005996.2:p.Pro279His,7/8,\N,Unknown significance,\N,missense_variant,24.4,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614820,4:6296892:T>G,NM_006005.3:c.837T>G,NP_005996.2:p.Pro279=,7/8,\N,Unknown significance,\N,synonymous_variant,9.477,0.000153092,EXAC_FIN_AF,WFS1
614821,4:6296893:G>T,NM_006005.3:c.838G>T,NP_005996.2:p.Glu280Ter,7/8,\N,Unknown significance,\N,stop_gained,39,\N,\N,WFS1
614822,4:6296894:A>G,NM_006005.3:c.839A>G,NP_005996.2:p.Glu280Gly,7/8,\N,Unknown significance,\N,missense_variant,29.2,\N,\N,WFS1
614823,4:6296896:G>A,NM_006005.3:c.841G>A,NP_005996.2:p.Asp281Asn,7/8,\N,Unknown significance,\N,missense_variant,24.4,\N,\N,WFS1
614824,4:6296896:G>C,NM_006005.3:c.841G>C,NP_005996.2:p.Asp281His,7/8,\N,Unknown significance,\N,missense_variant,27.2,\N,\N,WFS1
614825,4:6296897:A>C,NM_006005.3:c.842A>C,NP_005996.2:p.Asp281Ala,7/8,\N,Benign,\N,missense_variant,24.3,0.115,OTO_TR_AF,WFS1
614826,4:6296898:C>T,NM_006005.3:c.843C>T,NP_005996.2:p.Asp281=,7/8,\N,Unknown significance,\N,synonymous_variant,13.82,0.0000866401,EXAC_AMR_AF,WFS1
614827,4:6296899:C>T,NM_006005.3:c.844C>T,NP_005996.2:p.Leu282=,7/8,\N,Unknown significance,\N,synonymous_variant,12.01,0.000121168,EXAC_SAS_AF,WFS1
614828,4:6296906:T>C,NM_006005.3:c.851T>C,NP_005996.2:p.Leu284Pro,7/8,\N,Unknown significance,\N,missense_variant,26.5,0.0000153332,EXAC_NFE_AF,WFS1
614829,4:6296909:G>A,NM_006005.3:c.854G>A,NP_005996.2:p.Arg285His,7/8,\N,Benign,\N,missense_variant,21.4,0.0121,1KG_AFR_AF,WFS1
614830,4:6296912:T>C,NM_006005.3:c.857T>C,NP_005996.2:p.Leu286Pro,7/8,\N,Unknown significance,\N,missense_variant,15.43,0.000116279,EVS_EA_AF,WFS1
614831,4:6296913:G>C,NM_006005.3:c.858G>C,NP_005996.2:p.Leu286=,7/8,\N,Unknown significance,\N,synonymous_variant,6.353,0.0000153483,EXAC_NFE_AF,WFS1
614832,4:6296915:A>G,NM_006005.3:c.860A>G,NP_005996.2:p.Lys287Arg,7/8,\N,Likely benign,\N,missense_variant&splice_region_variant,0.162,0.0000153506,EXAC_NFE_AF,WFS1
614833,4:6296917:G>A,NM_006005.3:c.861+1G>A,\N,\N,7/7,Pathogenic,Wolfram syndrome,splice_donor_variant,24,\N,\N,WFS1
614834,4:6296918:T>G,NM_006005.3:c.861+2T>G,\N,\N,7/7,Unknown significance,\N,splice_donor_variant,23.4,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614835,4:6296922:T>G,NM_006005.3:c.861+6T>G,\N,\N,7/7,Unknown significance,\N,splice_region_variant&intron_variant,4.28,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
614836,4:6296926:C>G,NM_006005.3:c.861+10C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.399,0.0000307929,EXAC_NFE_AF,WFS1
614837,4:6296930:A>C,NM_006005.3:c.861+14A>C,\N,\N,7/7,Benign,\N,intron_variant,1.206,0.01,OTO_TR_AF,WFS1
614838,4:6296931:C>A,NM_006005.3:c.861+15C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.801,0.002,1KG_SAS_AF,WFS1
614839,4:6296932:C>T,NM_006005.3:c.861+16C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.666,0.0000868357,EXAC_AMR_AF,WFS1
614840,4:6296934:C>T,NM_006005.3:c.861+18C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.259,0.0000606208,EXAC_SAS_AF,WFS1
614841,4:6296935:G>A,NM_006005.3:c.861+19G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.351,0.000299103,EXAC_AFR_AF,WFS1
614842,4:6296935:G>T,NM_006005.3:c.861+19G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.116,0.000116877,EXAC_EAS_AF,WFS1
614843,4:6296942:C>A,NM_006005.3:c.861+26C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,4.791,0.000015466,EXAC_NFE_AF,WFS1
614844,4:6296943:C>A,NM_006005.3:c.861+27C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.76,0.001,1KG_SAS_AF,WFS1
614845,4:6296943:C>T,NM_006005.3:c.861+27C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.85,0.0000869263,EXAC_AMR_AF,WFS1
614846,4:6296944:G>A,NM_006005.3:c.861+28G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.169,0.00114155,EXAC_OTH_AF,WFS1
614847,4:6296948:C>G,NM_006005.3:c.861+32C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,5.574,0.0000154804,EXAC_NFE_AF,WFS1
614848,4:6296952:C>T,NM_006005.3:c.861+36C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,7.133,0.000181906,EXAC_SAS_AF,WFS1
614849,4:6296965:C>T,NM_006005.3:c.861+49C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.213,0.000015627,EXAC_NFE_AF,WFS1
614850,4:6296966:G>A,NM_006005.3:c.861+50G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.114,0.00030525,EXAC_AFR_AF,WFS1
614851,4:6296967:C>T,NM_006005.3:c.861+51C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.701,0.000116306,EVS_EA_AF,WFS1
614852,4:6296968:G>A,NM_006005.3:c.861+52G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.478,0.000060746,EXAC_SAS_AF,WFS1
614853,4:6296968:G>T,NM_006005.3:c.861+52G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.158,0.000060746,EXAC_SAS_AF,WFS1
614854,4:6296986:C>T,NM_006005.3:c.861+70C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.091,0.0008,1KG_AFR_AF,WFS1
614855,4:6296991:A>T,NM_006005.3:c.861+75A>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.714,0.0008,1KG_AFR_AF,WFS1
614856,4:6297008:G>A,NM_006005.3:c.861+92G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.96,0.001,1KG_SAS_AF,WFS1
614857,4:6297015:G>T,NM_006005.3:c.861+99G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.089,0.0015,1KG_AFR_AF,WFS1
614858,4:6297016:C>T,NM_006005.3:c.861+100C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.441,\N,\N,WFS1
614859,4:6297017:G>A,NM_006005.3:c.861+101G>A,\N,\N,7/7,Benign,\N,intron_variant,2.72,0.0681,1KG_AFR_AF,WFS1
614860,4:6297024:A>G,NM_006005.3:c.861+108A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.018,\N,\N,WFS1
614861,4:6297035:T>TA,NM_006005.3:c.861+120dup,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614862,4:6297040:C>T,NM_006005.3:c.861+124C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.972,0.0008,1KG_AFR_AF,WFS1
614863,4:6297042:G>A,NM_006005.3:c.861+126G>A,\N,\N,7/7,Benign,\N,intron_variant,1.63,0.0098,1KG_AFR_AF,WFS1
614864,4:6297045:C>T,NM_006005.3:c.861+129C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.791,0.002,1KG_EAS_AF,WFS1
614865,4:6297046:C>T,NM_006005.3:c.861+130C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.26,\N,\N,WFS1
614866,4:6297053:A>AGGG,NM_006005.3:c.861+137_861+138insGGG,\N,\N,7/7,Benign,\N,intron_variant,0.462,0.0605,1KG_AFR_AF,WFS1
614867,4:6297055:C>A,NM_006005.3:c.861+139C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.55,\N,\N,WFS1
614868,4:6297073:C>T,NM_006005.3:c.861+157C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.946,\N,\N,WFS1
614869,4:6297076:C>T,NM_006005.3:c.861+160C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.631,0.001,1KG_SAS_AF,WFS1
614870,4:6297092:C>T,NM_006005.3:c.861+176C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.831,\N,\N,WFS1
614871,4:6297093:G>A,NM_006005.3:c.861+177G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.606,0.0014,1KG_AMR_AF,WFS1
614872,4:6297101:G>A,NM_006005.3:c.861+185G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,4.422,\N,\N,WFS1
614873,4:6297103:CCTTT>C,NM_006005.3:c.861+192_861+195del,\N,\N,7/7,Benign,\N,intron_variant,6.278,0.059,1KG_AFR_AF,WFS1
614874,4:6297108:C>T,NM_006005.3:c.861+192C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.144,\N,\N,WFS1
614875,4:6297120:G>A,NM_006005.3:c.861+204G>A,\N,\N,7/7,Benign,\N,intron_variant,2.377,0.0613,1KG_AFR_AF,WFS1
614876,4:6297128:C>T,NM_006005.3:c.861+212C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.973,\N,\N,WFS1
614877,4:6297147:T>C,NM_006005.3:c.861+231T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,4.373,0.001,1KG_SAS_AF,WFS1
614878,4:6297154:G>C,NM_006005.3:c.861+238G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.609,\N,\N,WFS1
614879,4:6297182:C>T,NM_006005.3:c.861+266C>T,\N,\N,7/7,Benign,\N,intron_variant,3.508,0.0356,1KG_AFR_AF,WFS1
614880,4:6297183:T>G,NM_006005.3:c.861+267T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.868,0.003,1KG_AFR_AF,WFS1
614881,4:6297194:G>A,NM_006005.3:c.861+278G>A,\N,\N,7/7,Benign,\N,intron_variant,0.867,0.0506,1KG_EAS_AF,WFS1
614882,4:6297218:G>A,NM_006005.3:c.861+302G>A,\N,\N,7/7,Benign,\N,intron_variant,2.844,0.0166,1KG_AFR_AF,WFS1
614883,4:6297251:A>G,NM_006005.3:c.861+335A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,4.796,0.0015,1KG_AFR_AF,WFS1
614884,4:6297252:C>T,NM_006005.3:c.861+336C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.267,0.001,1KG_EAS_AF,WFS1
614885,4:6297283:T>A,NM_006005.3:c.861+367T>A,\N,\N,7/7,Benign,\N,intron_variant,8.185,0.0082,1KG_SAS_AF,WFS1
614886,4:6297298:T>C,NM_006005.3:c.861+382T>C,\N,\N,7/7,Benign,\N,intron_variant,1.183,0.0182,1KG_AFR_AF,WFS1
614887,4:6297313:C>T,NM_006005.3:c.861+397C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.271,\N,\N,WFS1
614888,4:6297314:G>A,NM_006005.3:c.861+398G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.969,\N,\N,WFS1
614889,4:6297326:C>G,NM_006005.3:c.861+410C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.423,\N,\N,WFS1
614890,4:6297327:C>T,NM_006005.3:c.861+411C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.54,0.0015,1KG_AFR_AF,WFS1
614891,4:6297328:G>T,NM_006005.3:c.861+412G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.232,0.0008,1KG_AFR_AF,WFS1
614892,4:6297334:G>A,NM_006005.3:c.861+418G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.293,0.0015,1KG_AFR_AF,WFS1
614893,4:6297349:A>G,NM_006005.3:c.861+433A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.237,\N,\N,WFS1
614894,4:6297383:A>G,NM_006005.3:c.861+467A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.583,\N,\N,WFS1
614895,4:6297401:C>G,NM_006005.3:c.861+485C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.463,0.0008,1KG_AFR_AF,WFS1
614896,4:6297432:G>T,NM_006005.3:c.861+516G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.055,0.001,1KG_EUR_AF,WFS1
614897,4:6297434:A>G,NM_006005.3:c.861+518A>G,\N,\N,7/7,Benign,\N,intron_variant,2.692,0.0598,1KG_AFR_AF,WFS1
614898,4:6297450:C>T,NM_006005.3:c.861+534C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.005,\N,\N,WFS1
614899,4:6297467:C>T,NM_006005.3:c.861+551C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.416,0.003,1KG_EAS_AF,WFS1
614900,4:6297476:C>T,NM_006005.3:c.861+560C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.286,0.0014,1KG_AMR_AF,WFS1
614901,4:6297477:G>A,NM_006005.3:c.861+561G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.694,\N,\N,WFS1
614902,4:6297483:AGGAAAGC>A,NM_006005.3:c.861+570_861+576del,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614903,4:6297487:A>AAGCGGGG,NM_006005.3:c.861+585_861+591dup,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
614904,4:6297487:AAGCGGGG>A,NM_006005.3:c.861+585_861+591del,\N,\N,7/7,Benign,\N,intron_variant,0.849,0.0123,1KG_SAS_AF,WFS1
614905,4:6297490:C>G,NM_006005.3:c.861+574C>G,\N,\N,7/7,Benign,\N,intron_variant,1.546,0.0287,1KG_AFR_AF,WFS1
614906,4:6297491:G>A,NM_006005.3:c.861+575G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.877,\N,\N,WFS1
614907,4:6297508:A>G,NM_006005.3:c.861+592A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.831,\N,\N,WFS1
614908,4:6297512:C>G,NM_006005.3:c.861+596C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.569,0.0008,1KG_AFR_AF,WFS1
614909,4:6297517:A>G,NM_006005.3:c.861+601A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.613,\N,\N,WFS1
614910,4:6297560:A>C,NM_006005.3:c.861+644A>C,\N,\N,7/7,Unknown significance,\N,intron_variant,8.999,\N,\N,WFS1
614911,4:6297574:CCT>C,NM_006005.3:c.861+662_861+663del,\N,\N,7/7,Benign,\N,intron_variant,7.371,0.0408,1KG_AFR_AF,WFS1
614912,4:6297581:C>T,NM_006005.3:c.861+665C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.984,0.0014,1KG_AMR_AF,WFS1
614913,4:6297603:C>T,NM_006005.3:c.861+687C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.465,0.003,1KG_AFR_AF,WFS1
614914,4:6297604:G>A,NM_006005.3:c.861+688G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.054,0.004,1KG_EAS_AF,WFS1
614915,4:6297606:A>G,NM_006005.3:c.861+690A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.633,0.0008,1KG_AFR_AF,WFS1
614916,4:6297629:G>T,NM_006005.3:c.861+713G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.094,\N,\N,WFS1
614917,4:6297646:A>C,NM_006005.3:c.861+730A>C,\N,\N,7/7,Benign,\N,intron_variant,0.041,0.9038,1KG_EAS_AF,WFS1
614918,4:6297647:C>T,NM_006005.3:c.861+731C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.345,0.001,1KG_EUR_AF,WFS1
614919,4:6297658:C>T,NM_006005.3:c.861+742C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.477,0.001,1KG_EUR_AF,WFS1
614920,4:6297664:G>A,NM_006005.3:c.861+748G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,4.822,0.001,1KG_SAS_AF,WFS1
614921,4:6297676:G>A,NM_006005.3:c.861+760G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.986,0.004,1KG_EAS_AF,WFS1
614922,4:6297699:C>T,NM_006005.3:c.861+783C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.976,\N,\N,WFS1
614923,4:6297705:C>T,NM_006005.3:c.861+789C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.869,0.002,1KG_EAS_AF,WFS1
614924,4:6297725:T>C,NM_006005.3:c.861+809T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.349,\N,\N,WFS1
614925,4:6297737:C>T,NM_006005.3:c.861+821C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.184,0.001,1KG_EUR_AF,WFS1
614926,4:6297741:G>A,NM_006005.3:c.861+825G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.912,0.001,1KG_EAS_AF,WFS1
614927,4:6297760:C>T,NM_006005.3:c.861+844C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.604,\N,\N,WFS1
614928,4:6297778:T>C,NM_006005.3:c.861+862T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.129,0.004,1KG_EAS_AF,WFS1
614929,4:6297779:G>A,NM_006005.3:c.861+863G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.87,\N,\N,WFS1
614930,4:6297805:G>A,NM_006005.3:c.861+889G>A,\N,\N,7/7,Benign,\N,intron_variant,1.879,0.0461,1KG_AFR_AF,WFS1
614931,4:6297828:G>A,NM_006005.3:c.861+912G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.96,\N,\N,WFS1
614932,4:6297830:G>A,NM_006005.3:c.861+914G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.163,0.001,1KG_SAS_AF,WFS1
614933,4:6297830:G>T,NM_006005.3:c.861+914G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.046,\N,\N,WFS1
614934,4:6297901:C>T,NM_006005.3:c.861+985C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.224,0.001,1KG_EUR_AF,WFS1
614935,4:6297907:C>G,NM_006005.3:c.861+991C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.062,0.0014,1KG_AMR_AF,WFS1
614936,4:6297907:C>T,NM_006005.3:c.861+991C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.149,\N,\N,WFS1
614937,4:6297908:G>A,NM_006005.3:c.861+992G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.615,0.0008,1KG_AFR_AF,WFS1
614938,4:6297942:C>T,NM_006005.3:c.861+1026C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.028,0.0008,1KG_AFR_AF,WFS1
614939,4:6297946:G>T,NM_006005.3:c.861+1030G>T,\N,\N,7/7,Benign,\N,intron_variant,1.661,0.0613,1KG_SAS_AF,WFS1
614940,4:6297947:G>T,NM_006005.3:c.861+1031G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.348,\N,\N,WFS1
614941,4:6297982:A>G,NM_006005.3:c.861+1066A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.271,\N,\N,WFS1
614942,4:6297989:G>C,NM_006005.3:c.861+1073G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.211,\N,\N,WFS1
614943,4:6298019:C>T,NM_006005.3:c.861+1103C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,5.218,0.001,1KG_EAS_AF,WFS1
614944,4:6298025:G>C,NM_006005.3:c.861+1109G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.521,\N,\N,WFS1
614945,4:6298062:G>A,NM_006005.3:c.861+1146G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.4,\N,\N,WFS1
614946,4:6298077:C>T,NM_006005.3:c.861+1161C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.192,0.001,1KG_SAS_AF,WFS1
614947,4:6298078:G>A,NM_006005.3:c.861+1162G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.507,0.0008,1KG_AFR_AF,WFS1
614948,4:6298104:G>T,NM_006005.3:c.861+1188G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.204,\N,\N,WFS1
614949,4:6298110:C>T,NM_006005.3:c.861+1194C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.849,0.0008,1KG_AFR_AF,WFS1
614950,4:6298152:C>T,NM_006005.3:c.861+1236C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.427,0.002,1KG_SAS_AF,WFS1
614951,4:6298178:A>G,NM_006005.3:c.861+1262A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.271,\N,\N,WFS1
614952,4:6298217:A>G,NM_006005.3:c.861+1301A>G,\N,\N,7/7,Benign,\N,intron_variant,0.293,0.0613,1KG_SAS_AF,WFS1
614953,4:6298221:T>C,NM_006005.3:c.861+1305T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,3.065,\N,\N,WFS1
614954,4:6298323:G>T,NM_006005.3:c.861+1407G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.922,0.002,1KG_EUR_AF,WFS1
614955,4:6298347:C>T,NM_006005.3:c.861+1431C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.842,0.003,1KG_AFR_AF,WFS1
614956,4:6298351:A>G,NM_006005.3:c.861+1435A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.467,0.0015,1KG_AFR_AF,WFS1
614957,4:6298361:G>A,NM_006005.3:c.861+1445G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,5.371,0.001,1KG_SAS_AF,WFS1
614958,4:6298363:G>A,NM_006005.3:c.861+1447G>A,\N,\N,7/7,Benign,\N,intron_variant,3.989,0.0219,1KG_EUR_AF,WFS1
614959,4:6298375:C>T,NM_006005.3:c.861+1459C>T,\N,\N,7/7,Benign,\N,intron_variant,6.793,0.9038,1KG_EAS_AF,WFS1
614960,4:6298412:A>G,NM_006005.3:c.861+1496A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.456,0.0014,1KG_AMR_AF,WFS1
614961,4:6298420:G>C,NM_006005.3:c.861+1504G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.34,0.0008,1KG_AFR_AF,WFS1
614962,4:6298421:G>A,NM_006005.3:c.861+1505G>A,\N,\N,7/7,Benign,\N,intron_variant,3.958,0.0083,1KG_AFR_AF,WFS1
614963,4:6298459:A>G,NM_006005.3:c.861+1543A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.462,\N,\N,WFS1
614964,4:6298466:C>T,NM_006005.3:c.861+1550C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.875,\N,\N,WFS1
614965,4:6298469:C>T,NM_006005.3:c.861+1553C>T,\N,\N,7/7,Benign,\N,intron_variant,1.941,0.007,1KG_EUR_AF,WFS1
614966,4:6298480:C>T,NM_006005.3:c.861+1564C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.294,\N,\N,WFS1
614967,4:6298489:C>G,NM_006005.3:c.861+1573C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.75,\N,\N,WFS1
614968,4:6298489:C>T,NM_006005.3:c.861+1573C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.742,\N,\N,WFS1
614969,4:6298490:G>A,NM_006005.3:c.861+1574G>A,\N,\N,7/7,Benign,\N,intron_variant,3.582,0.0079,1KG_EAS_AF,WFS1
614970,4:6298512:T>C,NM_006005.3:c.861+1596T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.625,0.0014,1KG_AMR_AF,WFS1
614971,4:6298582:C>T,NM_006005.3:c.861+1666C>T,\N,\N,7/7,Benign,\N,intron_variant,0.873,0.9038,1KG_EAS_AF,WFS1
614972,4:6298601:G>A,NM_006005.3:c.861+1685G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.378,0.004,1KG_EAS_AF,WFS1
614973,4:6298640:G>A,NM_006005.3:c.861+1724G>A,\N,\N,7/7,Benign,\N,intron_variant,0.941,0.0058,1KG_AMR_AF,WFS1
614974,4:6298641:T>A,NM_006005.3:c.861+1725T>A,\N,\N,7/7,Unknown significance,\N,intron_variant,6.015,\N,\N,WFS1
614975,4:6298642:G>A,NM_006005.3:c.861+1726G>A,\N,\N,7/7,Benign,\N,intron_variant,3.536,0.0821,1KG_AMR_AF,WFS1
614976,4:6298665:C>T,NM_006005.3:c.861+1749C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.665,\N,\N,WFS1
614977,4:6298679:A>T,NM_006005.3:c.861+1763A>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.061,0.001,1KG_EUR_AF,WFS1
614978,4:6298689:T>A,NM_006005.3:c.861+1773T>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.827,0.001,1KG_EUR_AF,WFS1
614979,4:6298705:C>A,NM_006005.3:c.861+1789C>A,\N,\N,7/7,Benign,\N,intron_variant,4.056,0.0825,1KG_AFR_AF,WFS1
614980,4:6298716:G>A,NM_006005.3:c.861+1800G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.542,\N,\N,WFS1
614981,4:6298724:T>C,NM_006005.3:c.861+1808T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.229,\N,\N,WFS1
614982,4:6298730:C>T,NM_006005.3:c.861+1814C>T,\N,\N,7/7,Benign,\N,intron_variant,0.647,0.0112,1KG_SAS_AF,WFS1
614983,4:6298740:C>T,NM_006005.3:c.861+1824C>T,\N,\N,7/7,Benign,\N,intron_variant,4.2,0.0231,1KG_AMR_AF,WFS1
614984,4:6298741:G>A,NM_006005.3:c.861+1825G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.91,0.0008,1KG_AFR_AF,WFS1
614985,4:6298745:G>A,NM_006005.3:c.861+1829G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,4.835,\N,\N,WFS1
614986,4:6298807:T>C,NM_006005.3:c.861+1891T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.462,0.001,1KG_EUR_AF,WFS1
614987,4:6298809:G>T,NM_006005.3:c.861+1893G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.224,0.001,1KG_EAS_AF,WFS1
614988,4:6298849:C>T,NM_006005.3:c.861+1933C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.144,0.0008,1KG_AFR_AF,WFS1
614989,4:6298892:T>G,NM_006005.3:c.861+1976T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.84,0.0014,1KG_AMR_AF,WFS1
614990,4:6298939:G>A,NM_006005.3:c.861+2023G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.257,\N,\N,WFS1
614991,4:6298951:C>T,NM_006005.3:c.861+2035C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.555,0.0014,1KG_AMR_AF,WFS1
614992,4:6298952:G>A,NM_006005.3:c.861+2036G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.669,\N,\N,WFS1
614993,4:6298958:T>C,NM_006005.3:c.861+2042T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.066,\N,\N,WFS1
614994,4:6298971:T>G,NM_006005.3:c.861+2055T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.321,\N,\N,WFS1
614995,4:6299006:G>T,NM_006005.3:c.861+2090G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.346,0.0045,1KG_AFR_AF,WFS1
614996,4:6299014:C>T,NM_006005.3:c.861+2098C>T,\N,\N,7/7,Benign,\N,intron_variant,2.896,0.0688,1KG_AFR_AF,WFS1
614997,4:6299015:G>A,NM_006005.3:c.861+2099G>A,\N,\N,7/7,Benign,\N,intron_variant,0.147,0.0061,1KG_SAS_AF,WFS1
614998,4:6299017:C>T,NM_006005.3:c.861+2101C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,5.486,\N,\N,WFS1
614999,4:6299072:G>A,NM_006005.3:c.861+2156G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,4.528,\N,\N,WFS1
615000,4:6299094:G>C,NM_006005.3:c.861+2178G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.143,0.001,1KG_EAS_AF,WFS1
615001,4:6299105:C>A,NM_006005.3:c.861+2189C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,5.349,0.0008,1KG_AFR_AF,WFS1
615002,4:6299106:T>C,NM_006005.3:c.861+2190T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.467,\N,\N,WFS1
615003,4:6299109:G>A,NM_006005.3:c.861+2193G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.548,0.002,1KG_EUR_AF,WFS1
615004,4:6299118:C>G,NM_006005.3:c.861+2202C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.034,\N,\N,WFS1
615005,4:6299136:T>C,NM_006005.3:c.861+2220T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.67,0.001,1KG_EUR_AF,WFS1
615006,4:6299141:C>T,NM_006005.3:c.861+2225C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.153,\N,\N,WFS1
615007,4:6299147:C>T,NM_006005.3:c.861+2231C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.626,0.001,1KG_SAS_AF,WFS1
615008,4:6299153:A>G,NM_006005.3:c.861+2237A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.399,\N,\N,WFS1
615009,4:6299204:C>T,NM_006005.3:c.861+2288C>T,\N,\N,7/7,Benign,\N,intron_variant,4.484,0.0174,1KG_AFR_AF,WFS1
615010,4:6299220:T>C,NM_006005.3:c.861+2304T>C,\N,\N,7/7,Benign,\N,intron_variant,1.86,0.0123,1KG_SAS_AF,WFS1
615011,4:6299230:T>G,NM_006005.3:c.861+2314T>G,\N,\N,7/7,Benign,\N,intron_variant,5.051,0.0194,1KG_SAS_AF,WFS1
615012,4:6299232:G>C,NM_006005.3:c.861+2316G>C,\N,\N,7/7,Benign,\N,intron_variant,0.413,0.0477,1KG_AFR_AF,WFS1
615013,4:6299245:C>T,NM_006005.3:c.861+2329C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.579,\N,\N,WFS1
615014,4:6299251:A>G,NM_006005.3:c.861+2335A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.748,0.0029,1KG_AMR_AF,WFS1
615015,4:6299266:G>A,NM_006005.3:c.861+2350G>A,\N,\N,7/7,Benign,\N,intron_variant,0.639,0.0119,1KG_EAS_AF,WFS1
615016,4:6299270:C>T,NM_006005.3:c.861+2354C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.131,0.0029,1KG_AMR_AF,WFS1
615017,4:6299271:G>A,NM_006005.3:c.861+2355G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.905,0.001,1KG_EAS_AF,WFS1
615018,4:6299275:A>G,NM_006005.3:c.861+2359A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.574,0.0008,1KG_AFR_AF,WFS1
615019,4:6299307:G>A,NM_006005.3:c.861+2391G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,4.559,0.0008,1KG_AFR_AF,WFS1
615020,4:6299311:C>T,NM_006005.3:c.861+2395C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.076,0.001,1KG_EAS_AF,WFS1
615021,4:6299332:C>T,NM_006005.3:c.861+2416C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.516,\N,\N,WFS1
615022,4:6299334:T>G,NM_006005.3:c.861+2418T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.916,0.003,1KG_EAS_AF,WFS1
615023,4:6299340:C>T,NM_006005.3:c.861+2424C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.09,0.0014,1KG_AMR_AF,WFS1
615024,4:6299341:G>A,NM_006005.3:c.861+2425G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.536,\N,\N,WFS1
615025,4:6299346:C>T,NM_006005.3:c.861+2430C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.829,0.002,1KG_SAS_AF,WFS1
615026,4:6299368:C>T,NM_006005.3:c.861+2452C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.324,\N,\N,WFS1
615027,4:6299379:G>C,NM_006005.3:c.861+2463G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.15,0.0008,1KG_AFR_AF,WFS1
615028,4:6299386:C>G,NM_006005.3:c.861+2470C>G,\N,\N,7/7,Benign,\N,intron_variant,1.128,0.0113,1KG_AFR_AF,WFS1
615029,4:6299387:G>A,NM_006005.3:c.861+2471G>A,\N,\N,7/7,Benign,\N,intron_variant,1.04,0.9038,1KG_EAS_AF,WFS1
615030,4:6299387:G>C,NM_006005.3:c.861+2471G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.176,\N,\N,WFS1
615031,4:6299394:C>G,NM_006005.3:c.861+2478C>G,\N,\N,7/7,Benign,\N,intron_variant,7.043,0.0121,1KG_AFR_AF,WFS1
615032,4:6299404:G>A,NM_006005.3:c.861+2488G>A,\N,\N,7/7,Benign,\N,intron_variant,1.547,0.0613,1KG_SAS_AF,WFS1
615033,4:6299418:C>G,NM_006005.3:c.861+2502C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.527,0.002,1KG_EAS_AF,WFS1
615034,4:6299493:C>T,NM_006005.3:c.861+2577C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.269,\N,\N,WFS1
615035,4:6299508:T>A,NM_006005.3:c.861+2592T>A,\N,\N,7/7,Unknown significance,\N,intron_variant,6.218,0.001,1KG_SAS_AF,WFS1
615036,4:6299509:G>A,NM_006005.3:c.861+2593G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.874,0.0023,1KG_AFR_AF,WFS1
615037,4:6299516:CCTT>C,NM_006005.3:c.861+2604_861+2606del,\N,\N,7/7,Benign,\N,intron_variant,3.478,0.0091,1KG_AFR_AF,WFS1
615038,4:6299541:A>C,NM_006005.3:c.861+2625A>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.465,\N,\N,WFS1
615039,4:6299603:C>T,NM_006005.3:c.861+2687C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.817,0.0008,1KG_AFR_AF,WFS1
615040,4:6299604:T>C,NM_006005.3:c.861+2688T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.382,\N,\N,WFS1
615041,4:6299618:C>A,NM_006005.3:c.861+2702C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.601,0.0008,1KG_AFR_AF,WFS1
615042,4:6299619:G>A,NM_006005.3:c.861+2703G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.689,\N,\N,WFS1
615043,4:6299621:TC>T,NM_006005.3:c.861+2708del,\N,\N,7/7,Unknown significance,\N,intron_variant,0.408,\N,\N,WFS1
615044,4:6299632:C>T,NM_006005.3:c.861+2716C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.083,0.0008,1KG_AFR_AF,WFS1
615045,4:6299641:G>A,NM_006005.3:c.861+2725G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.681,0.001,1KG_EAS_AF,WFS1
615046,4:6299649:C>G,NM_006005.3:c.861+2733C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.405,0.0023,1KG_AFR_AF,WFS1
615047,4:6299658:C>T,NM_006005.3:c.862-2726C>T,\N,\N,7/7,Benign,\N,intron_variant,4.326,0.0331,1KG_AMR_AF,WFS1
615048,4:6299683:C>T,NM_006005.3:c.862-2701C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.345,0.0008,1KG_AFR_AF,WFS1
615049,4:6299684:G>A,NM_006005.3:c.862-2700G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.293,0.0008,1KG_AFR_AF,WFS1
615050,4:6299691:A>G,NM_006005.3:c.862-2693A>G,\N,\N,7/7,Benign,\N,intron_variant,0.85,0.0688,1KG_AFR_AF,WFS1
615051,4:6299693:C>T,NM_006005.3:c.862-2691C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.891,\N,\N,WFS1
615052,4:6299711:T>TC,NM_006005.3:c.862-2671dup,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615053,4:6299736:A>G,NM_006005.3:c.862-2648A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,4.828,0.0015,1KG_AFR_AF,WFS1
615054,4:6299758:A>G,NM_006005.3:c.862-2626A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.15,\N,\N,WFS1
615055,4:6299769:T>C,NM_006005.3:c.862-2615T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.086,0.001,1KG_EAS_AF,WFS1
615056,4:6299774:A>G,NM_006005.3:c.862-2610A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.045,\N,\N,WFS1
615057,4:6299777:G>T,NM_006005.3:c.862-2607G>T,\N,\N,7/7,Benign,\N,intron_variant,0.214,0.0099,1KG_EAS_AF,WFS1
615058,4:6299786:A>G,NM_006005.3:c.862-2598A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.324,0.001,1KG_SAS_AF,WFS1
615059,4:6299842:C>T,NM_006005.3:c.862-2542C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.942,\N,\N,WFS1
615060,4:6299846:C>T,NM_006005.3:c.862-2538C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.05,0.0008,1KG_AFR_AF,WFS1
615061,4:6299847:G>A,NM_006005.3:c.862-2537G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.939,0.001,1KG_EAS_AF|1KG_EUR_AF|1KG_SAS_AF,WFS1
615062,4:6299882:C>T,NM_006005.3:c.862-2502C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.554,0.0008,1KG_AFR_AF,WFS1
615063,4:6299902:C>T,NM_006005.3:c.862-2482C>T,\N,\N,7/7,Benign,\N,intron_variant,7.573,0.0507,1KG_AFR_AF,WFS1
615064,4:6299903:G>C,NM_006005.3:c.862-2481G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,4.696,0.002,1KG_SAS_AF,WFS1
615065,4:6299908:G>GC,NM_006005.3:c.862-2471dup,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615066,4:6299913:C>T,NM_006005.3:c.862-2471C>T,\N,\N,7/7,Benign,\N,intron_variant,4.692,0.6875,1KG_EAS_AF,WFS1
615067,4:6299913:CA>TG,NM_006005.3:c.862-2471_862-2470inv,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615068,4:6299914:A>G,NM_006005.3:c.862-2470A>G,\N,\N,7/7,Benign,\N,intron_variant,3.621,0.9038,1KG_EAS_AF,WFS1
615069,4:6299914:A>TG,NM_006005.3:c.862-2470delinsTG,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615070,4:6299918:G>C,NM_006005.3:c.862-2466G>C,\N,\N,7/7,Benign,\N,intron_variant,2.091,0.007,1KG_EUR_AF,WFS1
615071,4:6299940:C>T,NM_006005.3:c.862-2444C>T,\N,\N,7/7,Benign,\N,intron_variant,0.482,0.8145,1KG_EAS_AF,WFS1
615072,4:6299947:C>T,NM_006005.3:c.862-2437C>T,\N,\N,7/7,Benign,\N,intron_variant,2.704,0.005,1KG_EAS_AF,WFS1
615073,4:6299962:G>A,NM_006005.3:c.862-2422G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.257,0.0038,1KG_AFR_AF,WFS1
615074,4:6299990:C>T,NM_006005.3:c.862-2394C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.685,0.002,1KG_SAS_AF,WFS1
615075,4:6299994:C>T,NM_006005.3:c.862-2390C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.81,\N,\N,WFS1
615076,4:6299995:G>A,NM_006005.3:c.862-2389G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.915,\N,\N,WFS1
615077,4:6300004:C>T,NM_006005.3:c.862-2380C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.008,\N,\N,WFS1
615078,4:6300008:G>A,NM_006005.3:c.862-2376G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.938,0.002,1KG_EUR_AF,WFS1
615079,4:6300019:A>G,NM_006005.3:c.862-2365A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.603,0.002,1KG_EAS_AF,WFS1
615080,4:6300048:A>G,NM_006005.3:c.862-2336A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.42,0.0008,1KG_AFR_AF,WFS1
615081,4:6300058:T>C,NM_006005.3:c.862-2326T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.695,\N,\N,WFS1
615082,4:6300072:G>C,NM_006005.3:c.862-2312G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,3.817,\N,\N,WFS1
615083,4:6300072:G>T,NM_006005.3:c.862-2312G>T,\N,\N,7/7,Benign,\N,intron_variant,4.981,0.0123,1KG_SAS_AF,WFS1
615084,4:6300097:T>A,NM_006005.3:c.862-2287T>A,\N,\N,7/7,Unknown significance,\N,intron_variant,9.628,0.0008,1KG_AFR_AF,WFS1
615085,4:6300114:T>G,NM_006005.3:c.862-2270T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,11.42,\N,\N,WFS1
615086,4:6300124:C>T,NM_006005.3:c.862-2260C>T,\N,\N,7/7,Benign,\N,intron_variant,10.44,0.0053,1KG_AFR_AF,WFS1
615087,4:6300134:G>C,NM_006005.3:c.862-2250G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.689,0.001,1KG_EAS_AF|1KG_SAS_AF,WFS1
615088,4:6300137:C>T,NM_006005.3:c.862-2247C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.088,0.0031,1KG_SAS_AF,WFS1
615089,4:6300138:G>A,NM_006005.3:c.862-2246G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.888,0.001,1KG_SAS_AF,WFS1
615090,4:6300177:A>C,NM_006005.3:c.862-2207A>C,\N,\N,7/7,Benign,\N,intron_variant,1.658,0.005,1KG_EAS_AF,WFS1
615091,4:6300192:TAGCTGCTTTAATCGTTTATTTGCTTGTTATAAAACAGAGATTAAGTGGACTGTCACAAATATACATG>T,NM_006005.3:c.862-2190_862-2124del,\N,\N,7/7,Benign,\N,intron_variant,\N,0.0089,1KG_EUR_AF,WFS1
615092,4:6300198:C>T,NM_006005.3:c.862-2186C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.436,\N,\N,WFS1
615093,4:6300205:CGTTTATTTGCT>C,NM_006005.3:c.862-2178_862-2168del,\N,\N,7/7,Benign,\N,intron_variant,\N,0.0169,1KG_EAS_AF,WFS1
615094,4:6300216:T>C,NM_006005.3:c.862-2168T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.856,\N,\N,WFS1
615095,4:6300221:A>G,NM_006005.3:c.862-2163A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.369,\N,\N,WFS1
615096,4:6300227:CAG>C,NM_006005.3:c.862-2153_862-2152del,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615097,4:6300273:G>A,NM_006005.3:c.862-2111G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.592,0.0043,1KG_AMR_AF,WFS1
615098,4:6300282:C>T,NM_006005.3:c.862-2102C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.873,\N,\N,WFS1
615099,4:6300285:G>A,NM_006005.3:c.862-2099G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.706,\N,\N,WFS1
615100,4:6300291:G>A,NM_006005.3:c.862-2093G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.857,0.0014,1KG_AMR_AF,WFS1
615101,4:6300293:G>C,NM_006005.3:c.862-2091G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.847,\N,\N,WFS1
615102,4:6300296:T>C,NM_006005.3:c.862-2088T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.819,\N,\N,WFS1
615103,4:6300305:TCCTAAACACTTC>T,NM_006005.3:c.862-2077_862-2066del,\N,\N,7/7,Benign,\N,intron_variant,3.623,0.0151,1KG_AFR_AF,WFS1
615104,4:6300307:C>A,NM_006005.3:c.862-2077C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.779,\N,\N,WFS1
615105,4:6300307:C>T,NM_006005.3:c.862-2077C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.042,\N,\N,WFS1
615106,4:6300308:TA>T,NM_006005.3:c.862-2073del,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615107,4:6300309:A>G,NM_006005.3:c.862-2075A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.48,0.0008,1KG_AFR_AF,WFS1
615108,4:6300313:A>G,NM_006005.3:c.862-2071A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.872,0.002,1KG_SAS_AF,WFS1
615109,4:6300314:C>T,NM_006005.3:c.862-2070C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.902,\N,\N,WFS1
615110,4:6300318:C>T,NM_006005.3:c.862-2066C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.494,\N,\N,WFS1
615111,4:6300324:T>C,NM_006005.3:c.862-2060T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.164,\N,\N,WFS1
615112,4:6300339:C>A,NM_006005.3:c.862-2045C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.803,\N,\N,WFS1
615113,4:6300353:A>G,NM_006005.3:c.862-2031A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.404,0.001,1KG_SAS_AF,WFS1
615114,4:6300359:C>T,NM_006005.3:c.862-2025C>T,\N,\N,7/7,Benign,\N,intron_variant,0.479,0.0113,1KG_AFR_AF,WFS1
615115,4:6300370:G>T,NM_006005.3:c.862-2014G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.668,\N,\N,WFS1
615116,4:6300379:GCACA>G,NM_006005.3:c.862-2001_862-1998del,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615117,4:6300383:A>ACACT,NM_006005.3:c.862-1998_862-1995dup,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615118,4:6300383:ACACT>A,NM_006005.3:c.862-1998_862-1995del,\N,\N,7/7,Benign,\N,intron_variant,7.156,0.119,1KG_EAS_AF,WFS1
615119,4:6300399:C>T,NM_006005.3:c.862-1985C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.053,\N,\N,WFS1
615120,4:6300410:T>G,NM_006005.3:c.862-1974T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,4.173,0.001,1KG_SAS_AF,WFS1
615121,4:6300419:CCCTCT>C,NM_006005.3:c.862-1958_862-1954del,\N,\N,7/7,Benign,\N,intron_variant,2.036,0.0101,1KG_AMR_AF,WFS1
615122,4:6300421:C>T,NM_006005.3:c.862-1963C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.432,0.0014,1KG_AMR_AF,WFS1
615123,4:6300448:T>C,NM_006005.3:c.862-1936T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.681,\N,\N,WFS1
615124,4:6300453:T>G,NM_006005.3:c.862-1931T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.789,0.0015,1KG_AFR_AF,WFS1
615125,4:6300463:C>T,NM_006005.3:c.862-1921C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.771,\N,\N,WFS1
615126,4:6300481:A>G,NM_006005.3:c.862-1903A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.186,\N,\N,WFS1
615127,4:6300493:C>T,NM_006005.3:c.862-1891C>T,\N,\N,7/7,Benign,\N,intron_variant,6.762,0.0318,1KG_AFR_AF,WFS1
615128,4:6300500:T>C,NM_006005.3:c.862-1884T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,7.673,\N,\N,WFS1
615129,4:6300524:G>C,NM_006005.3:c.862-1860G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,5.395,0.0008,1KG_AFR_AF,WFS1
615130,4:6300527:T>G,NM_006005.3:c.862-1857T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,4.869,0.001,1KG_EAS_AF,WFS1
615131,4:6300546:C>T,NM_006005.3:c.862-1838C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,6.753,0.001,1KG_EUR_AF,WFS1
615132,4:6300548:C>G,NM_006005.3:c.862-1836C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,5.682,\N,\N,WFS1
615133,4:6300570:C>T,NM_006005.3:c.862-1814C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,6.555,0.003,1KG_AFR_AF,WFS1
615134,4:6300571:T>C,NM_006005.3:c.862-1813T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.993,0.004,1KG_EAS_AF,WFS1
615135,4:6300577:G>T,NM_006005.3:c.862-1807G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.877,0.0029,1KG_AMR_AF,WFS1
615136,4:6300580:T>C,NM_006005.3:c.862-1804T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.543,0.001,1KG_EAS_AF,WFS1
615137,4:6300589:G>A,NM_006005.3:c.862-1795G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.169,\N,\N,WFS1
615138,4:6300606:T>G,NM_006005.3:c.862-1778T>G,\N,\N,7/7,Benign,\N,intron_variant,3.777,0.0862,1KG_AFR_AF,WFS1
615139,4:6300615:T>G,NM_006005.3:c.862-1769T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.134,\N,\N,WFS1
615140,4:6300617:T>C,NM_006005.3:c.862-1767T>C,\N,\N,7/7,Benign,\N,intron_variant,0.497,0.1838,1KG_AFR_AF,WFS1
615141,4:6300619:G>T,NM_006005.3:c.862-1765G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.525,0.0008,1KG_AFR_AF,WFS1
615142,4:6300628:C>A,NM_006005.3:c.862-1756C>A,\N,\N,7/7,Benign,\N,intron_variant,2.421,0.0605,1KG_AFR_AF,WFS1
615143,4:6300628:C>T,NM_006005.3:c.862-1756C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.586,0.0014,1KG_AMR_AF,WFS1
615144,4:6300644:T>TG,NM_006005.3:c.862-1734dup,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615145,4:6300648:G>T,NM_006005.3:c.862-1736G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.401,0.002,1KG_EAS_AF,WFS1
615146,4:6300654:C>G,NM_006005.3:c.862-1730C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.412,\N,\N,WFS1
615147,4:6300662:A>G,NM_006005.3:c.862-1722A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,5.043,0.0029,1KG_AMR_AF,WFS1
615148,4:6300672:T>G,NM_006005.3:c.862-1712T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,5.02,0.001,1KG_EUR_AF,WFS1
615149,4:6300699:A>T,NM_006005.3:c.862-1685A>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.778,0.001,1KG_EAS_AF,WFS1
615150,4:6300718:C>T,NM_006005.3:c.862-1666C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.894,0.0008,1KG_AFR_AF,WFS1
615151,4:6300736:A>G,NM_006005.3:c.862-1648A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.012,0.0008,1KG_AFR_AF,WFS1
615152,4:6300739:C>T,NM_006005.3:c.862-1645C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.327,0.002,1KG_EAS_AF,WFS1
615153,4:6300740:G>A,NM_006005.3:c.862-1644G>A,\N,\N,7/7,Benign,\N,intron_variant,4.486,0.0053,1KG_AFR_AF,WFS1
615154,4:6300742:CCACTTCCTGGTGTT>C,NM_006005.3:c.862-1641_862-1628del,\N,\N,7/7,Unknown significance,\N,intron_variant,4.628,0.0031,1KG_SAS_AF,WFS1
615155,4:6300785:G>A,NM_006005.3:c.862-1599G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.798,\N,\N,WFS1
615156,4:6300831:C>G,NM_006005.3:c.862-1553C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.478,0.001,1KG_SAS_AF,WFS1
615157,4:6300833:C>T,NM_006005.3:c.862-1551C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.532,0.0008,1KG_AFR_AF,WFS1
615158,4:6300835:A>G,NM_006005.3:c.862-1549A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.819,\N,\N,WFS1
615159,4:6300837:G>A,NM_006005.3:c.862-1547G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.299,0.0029,1KG_AMR_AF,WFS1
615160,4:6300856:C>T,NM_006005.3:c.862-1528C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,6.341,0.002,1KG_EUR_AF,WFS1
615161,4:6300862:A>C,NM_006005.3:c.862-1522A>C,\N,\N,7/7,Unknown significance,\N,intron_variant,4.071,\N,\N,WFS1
615162,4:6300876:G>A,NM_006005.3:c.862-1508G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.438,0.001,1KG_EAS_AF,WFS1
615163,4:6300882:C>T,NM_006005.3:c.862-1502C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,5.2,0.002,1KG_EAS_AF,WFS1
615164,4:6300885:T>C,NM_006005.3:c.862-1499T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,3.436,\N,\N,WFS1
615165,4:6300890:T>G,NM_006005.3:c.862-1494T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,7.151,\N,\N,WFS1
615166,4:6300893:C>T,NM_006005.3:c.862-1491C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,8.378,0.0023,1KG_AFR_AF,WFS1
615167,4:6300924:C>G,NM_006005.3:c.862-1460C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,7.534,\N,\N,WFS1
615168,4:6300936:G>A,NM_006005.3:c.862-1448G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.317,0.0014,1KG_AMR_AF,WFS1
615169,4:6300959:G>A,NM_006005.3:c.862-1425G>A,\N,\N,7/7,Benign,\N,intron_variant,0.824,0.0091,1KG_AFR_AF,WFS1
615170,4:6300974:C>T,NM_006005.3:c.862-1410C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.796,\N,\N,WFS1
615171,4:6300991:C>T,NM_006005.3:c.862-1393C>T,\N,\N,7/7,Benign,\N,intron_variant,5.028,0.025,1KG_AFR_AF,WFS1
615172,4:6300997:T>G,NM_006005.3:c.862-1387T>G,\N,\N,7/7,Benign,\N,intron_variant,1.9,0.0061,1KG_AFR_AF,WFS1
615173,4:6301020:G>A,NM_006005.3:c.862-1364G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.078,0.0008,1KG_AFR_AF,WFS1
615174,4:6301023:T>C,NM_006005.3:c.862-1361T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.093,\N,\N,WFS1
615175,4:6301034:C>G,NM_006005.3:c.862-1350C>G,\N,\N,7/7,Benign,\N,intron_variant,3.595,0.0675,1KG_SAS_AF,WFS1
615176,4:6301046:TCTGAC>T,NM_006005.3:c.862-1335_862-1331del,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615177,4:6301058:G>A,NM_006005.3:c.862-1326G>A,\N,\N,7/7,Benign,\N,intron_variant,0.103,0.9038,1KG_EAS_AF,WFS1
615178,4:6301071:C>T,NM_006005.3:c.862-1313C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.694,0.0008,1KG_AFR_AF,WFS1
615179,4:6301077:A>G,NM_006005.3:c.862-1307A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,3.718,\N,\N,WFS1
615180,4:6301079:C>T,NM_006005.3:c.862-1305C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.422,0.004,1KG_EUR_AF,WFS1
615181,4:6301083:A>C,NM_006005.3:c.862-1301A>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.877,\N,\N,WFS1
615182,4:6301083:A>T,NM_006005.3:c.862-1301A>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.449,\N,\N,WFS1
615183,4:6301096:G>A,NM_006005.3:c.862-1288G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,4.551,\N,\N,WFS1
615184,4:6301139:G>A,NM_006005.3:c.862-1245G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.133,0.001,1KG_EUR_AF,WFS1
615185,4:6301150:T>C,NM_006005.3:c.862-1234T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,6.891,0.0008,1KG_AFR_AF,WFS1
615186,4:6301152:T>C,NM_006005.3:c.862-1232T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,4.923,0.004,1KG_EAS_AF,WFS1
615187,4:6301161:A>G,NM_006005.3:c.862-1223A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.35,0.0008,1KG_AFR_AF,WFS1
615188,4:6301165:G>A,NM_006005.3:c.862-1219G>A,\N,\N,7/7,Benign,\N,intron_variant,3.286,0.0378,1KG_SAS_AF,WFS1
615189,4:6301169:A>G,NM_006005.3:c.862-1215A>G,\N,\N,7/7,Benign,\N,intron_variant,2.188,0.0098,1KG_AFR_AF,WFS1
615190,4:6301172:G>A,NM_006005.3:c.862-1212G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.761,0.004,1KG_EAS_AF,WFS1
615191,4:6301184:TGTGTGAGGGTGCAC>T,NM_006005.3:c.862-1194_862-1181del,\N,\N,7/7,Benign,\N,intron_variant,2.021,0.0151,1KG_AFR_AF,WFS1
615192,4:6301191:G>C,NM_006005.3:c.862-1193G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.108,\N,\N,WFS1
615193,4:6301192:GGTGCACGTGTGGGGGTGGGT>G,NM_006005.3:c.862-1180_862-1161del,\N,\N,7/7,Unknown significance,\N,intron_variant,1.216,\N,\N,WFS1
615194,4:6301194:T>G,NM_006005.3:c.862-1190T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.311,\N,\N,WFS1
615195,4:6301198:C>CGT,NM_006005.3:c.862-1182_862-1181dup,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615196,4:6301198:CGT>C,NM_006005.3:c.862-1182_862-1181del,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615197,4:6301199:G>C,NM_006005.3:c.862-1185G>C,\N,\N,7/7,Benign,\N,intron_variant,0.473,0.005,1KG_EAS_AF,WFS1
615198,4:6301203:G>GTGTA,NM_006005.3:c.862-1181_862-1180insTGTA,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615199,4:6301225:G>T,NM_006005.3:c.862-1159G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.766,0.0015,1KG_AFR_AF,WFS1
615200,4:6301232:T>G,NM_006005.3:c.862-1152T>G,\N,\N,7/7,Benign,\N,intron_variant,3.053,0.0058,1KG_AMR_AF,WFS1
615201,4:6301238:G>A,NM_006005.3:c.862-1146G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.144,\N,\N,WFS1
615202,4:6301246:G>C,NM_006005.3:c.862-1138G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.259,\N,\N,WFS1
615203,4:6301248:G>T,NM_006005.3:c.862-1136G>T,\N,\N,7/7,Benign,\N,intron_variant,0.32,0.0666,1KG_AFR_AF,WFS1
615204,4:6301250:A>ATG,NM_006005.3:c.862-1130_862-1129dup,\N,\N,7/7,Unknown significance,\N,intron_variant,0.151,\N,\N,WFS1
615205,4:6301258:AG>A,NM_006005.3:c.862-1122del,\N,\N,7/7,Benign,\N,intron_variant,0.532,0.0331,1KG_AMR_AF,WFS1
615206,4:6301275:A>ATG,NM_006005.3:c.862-1101_862-1100dup,\N,\N,7/7,Benign,\N,intron_variant,0.145,0.9911,1KG_EAS_AF,WFS1
615207,4:6301286:G>A,NM_006005.3:c.862-1098G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.25,\N,\N,WFS1
615208,4:6301289:GT>G,NM_006005.3:c.862-1094del,\N,\N,7/7,Benign,\N,intron_variant,2.353,0.0123,1KG_SAS_AF,WFS1
615209,4:6301298:G>A,NM_006005.3:c.862-1086G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.836,\N,\N,WFS1
615210,4:6301325:G>GGTT,NM_006005.3:c.862-1058_862-1056dup,\N,\N,7/7,Benign,\N,intron_variant,1.494,0.8899,1KG_EAS_AF,WFS1
615211,4:6301331:A>T,NM_006005.3:c.862-1053A>T,\N,\N,7/7,Benign,\N,intron_variant,2.348,0.0562,1KG_SAS_AF,WFS1
615212,4:6301332:A>T,NM_006005.3:c.862-1052A>T,\N,\N,7/7,Benign,\N,intron_variant,1.717,0.0562,1KG_SAS_AF,WFS1
615213,4:6301341:G>C,NM_006005.3:c.862-1043G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.257,\N,\N,WFS1
615214,4:6301346:C>CGT,NM_006005.3:c.862-1029_862-1028dup,\N,\N,7/7,Benign,\N,intron_variant,0.923,0.8829,1KG_EAS_AF,WFS1
615215,4:6301346:C>CGTGT,NM_006005.3:c.862-1031_862-1028dup,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615216,4:6301389:TA>T,NM_006005.3:c.862-994del,\N,\N,7/7,Benign,\N,intron_variant,4.645,0.0212,1KG_AFR_AF,WFS1
615217,4:6301395:T>G,NM_006005.3:c.862-989T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,4.699,\N,\N,WFS1
615218,4:6301397:GGTT>G,NM_006005.3:c.862-983_862-981del,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615219,4:6301407:G>A,NM_006005.3:c.862-977G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.544,0.001,1KG_SAS_AF,WFS1
615220,4:6301449:G>A,NM_006005.3:c.862-935G>A,\N,\N,7/7,Benign,\N,intron_variant,1.68,0.0377,1KG_EAS_AF,WFS1
615221,4:6301451:G>T,NM_006005.3:c.862-933G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.704,\N,\N,WFS1
615222,4:6301459:G>A,NM_006005.3:c.862-925G>A,\N,\N,7/7,Benign,\N,intron_variant,1.268,0.9028,1KG_EAS_AF,WFS1
615223,4:6301469:C>CGT,NM_006005.3:c.862-904_862-903dup,\N,\N,7/7,Benign,\N,intron_variant,0.189,0.006,1KG_EAS_AF,WFS1
615224,4:6301469:C>T,NM_006005.3:c.862-915C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.11,\N,\N,WFS1
615225,4:6301485:G>GGTGGGTTGCGT,NM_006005.3:c.862-895_862-885dup,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615226,4:6301485:GGTGGGTTGCGT>G,NM_006005.3:c.862-895_862-885del,\N,\N,7/7,Unknown significance,\N,intron_variant,1.431,\N,\N,WFS1
615227,4:6301522:GGTT>G,NM_006005.3:c.862-858_862-856del,\N,\N,7/7,Benign,\N,intron_variant,2.393,0.0265,1KG_AFR_AF,WFS1
615228,4:6301528:T>G,NM_006005.3:c.862-856T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.913,\N,\N,WFS1
615229,4:6301528:TTGAA>T,NM_006005.3:c.862-853_862-850del,\N,\N,7/7,Unknown significance,\N,intron_variant,2.074,\N,\N,WFS1
615230,4:6301536:G>A,NM_006005.3:c.862-848G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.207,\N,\N,WFS1
615231,4:6301547:G>A,NM_006005.3:c.862-837G>A,\N,\N,7/7,Benign,\N,intron_variant,2.121,0.0363,1KG_AFR_AF,WFS1
615232,4:6301554:T>A,NM_006005.3:c.862-830T>A,\N,\N,7/7,Benign,\N,intron_variant,5.241,0.0983,1KG_AFR_AF,WFS1
615233,4:6301557:A>ATGTG,NM_006005.3:c.862-825_862-822dup,\N,\N,7/7,Benign,\N,intron_variant,0.318,0.0166,1KG_AFR_AF,WFS1
615234,4:6301567:G>A,NM_006005.3:c.862-817G>A,\N,\N,7/7,Benign,\N,intron_variant,3.092,0.0613,1KG_SAS_AF,WFS1
615235,4:6301585:C>T,NM_006005.3:c.862-799C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.144,\N,\N,WFS1
615236,4:6301586:G>A,NM_006005.3:c.862-798G>A,\N,\N,7/7,Benign,\N,intron_variant,0.942,0.0098,1KG_AFR_AF,WFS1
615237,4:6301603:C>T,NM_006005.3:c.862-781C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.917,\N,\N,WFS1
615238,4:6301607:A>ATG,NM_006005.3:c.862-767_862-766dup,\N,\N,7/7,Unknown significance,\N,intron_variant,0.196,\N,\N,WFS1
615239,4:6301628:TTG>T,NM_006005.3:c.862-744_862-743del,\N,\N,7/7,Benign,\N,intron_variant,3.547,0.9834,1KG_AFR_AF,WFS1
615240,4:6301628:TTGTGTG>T,NM_006005.3:c.862-748_862-743del,\N,\N,7/7,Unknown significance,\N,intron_variant,3.628,\N,\N,WFS1
615241,4:6301645:G>C,NM_006005.3:c.862-739G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.806,0.0014,1KG_AMR_AF,WFS1
615242,4:6301655:G>A,NM_006005.3:c.862-729G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.953,0.001,1KG_EUR_AF,WFS1
615243,4:6301662:TGC>T,NM_006005.3:c.862-720_862-719del,\N,\N,7/7,Unknown significance,\N,intron_variant,2.84,\N,\N,WFS1
615244,4:6301665:G>A,NM_006005.3:c.862-719G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.887,0.004,1KG_EUR_AF,WFS1
615245,4:6301668:T>G,NM_006005.3:c.862-716T>G,\N,\N,7/7,Benign,\N,intron_variant,3.773,0.0061,1KG_AFR_AF,WFS1
615246,4:6301685:C>T,NM_006005.3:c.862-699C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.164,\N,\N,WFS1
615247,4:6301685:CGT>C,NM_006005.3:c.862-687_862-686del,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615248,4:6301685:CGTGT>C,NM_006005.3:c.862-689_862-686del,\N,\N,7/7,Unknown significance,\N,intron_variant,2.557,\N,\N,WFS1
615249,4:6301699:CACGTGTGTGT>C,NM_006005.3:c.862-681_862-672del,\N,\N,7/7,Benign,\N,intron_variant,2.591,0.0295,1KG_AFR_AF,WFS1
615250,4:6301702:G>A,NM_006005.3:c.862-682G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.056,0.001,1KG_SAS_AF,WFS1
615251,4:6301703:T>G,NM_006005.3:c.862-681T>G,\N,\N,7/7,Benign,\N,intron_variant,3.41,0.0613,1KG_SAS_AF,WFS1
615252,4:6301712:G>A,NM_006005.3:c.862-672G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.767,0.0038,1KG_AFR_AF,WFS1
615253,4:6301723:G>A,NM_006005.3:c.862-661G>A,\N,\N,7/7,Benign,\N,intron_variant,7.018,0.0242,1KG_AFR_AF,WFS1
615254,4:6301727:T>G,NM_006005.3:c.862-657T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,7.985,0.0008,1KG_AFR_AF,WFS1
615255,4:6301750:C>T,NM_006005.3:c.862-634C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.001,\N,\N,WFS1
615256,4:6301751:G>A,NM_006005.3:c.862-633G>A,\N,\N,7/7,Benign,\N,intron_variant,3.704,0.0227,1KG_AFR_AF,WFS1
615257,4:6301756:T>C,NM_006005.3:c.862-628T>C,\N,\N,7/7,Benign,\N,intron_variant,0.622,0.0318,1KG_AFR_AF,WFS1
615258,4:6301770:C>T,NM_006005.3:c.862-614C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,5.228,\N,\N,WFS1
615259,4:6301772:C>T,NM_006005.3:c.862-612C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.716,0.0014,1KG_AMR_AF,WFS1
615260,4:6301774:C>G,NM_006005.3:c.862-610C>G,\N,\N,7/7,Benign,\N,intron_variant,1.542,0.0129,1KG_EUR_AF,WFS1
615261,4:6301774:C>T,NM_006005.3:c.862-610C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.688,0.0029,1KG_AMR_AF,WFS1
615262,4:6301775:G>A,NM_006005.3:c.862-609G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.129,0.0008,1KG_AFR_AF,WFS1
615263,4:6301784:G>A,NM_006005.3:c.862-600G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.69,0.001,1KG_EAS_AF,WFS1
615264,4:6301789:G>C,NM_006005.3:c.862-595G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.541,0.0014,1KG_AMR_AF,WFS1
615265,4:6301804:T>G,NM_006005.3:c.862-580T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.906,\N,\N,WFS1
615266,4:6301810:G>C,NM_006005.3:c.862-574G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.368,\N,\N,WFS1
615267,4:6301827:C>G,NM_006005.3:c.862-557C>G,\N,\N,7/7,Benign,\N,intron_variant,1.492,0.0552,1KG_AFR_AF,WFS1
615268,4:6301833:C>T,NM_006005.3:c.862-551C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.483,0.001,1KG_EAS_AF,WFS1
615269,4:6301852:C>G,NM_006005.3:c.862-532C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.248,0.002,1KG_SAS_AF,WFS1
615270,4:6301864:G>A,NM_006005.3:c.862-520G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.417,0.001,1KG_SAS_AF,WFS1
615271,4:6301875:C>T,NM_006005.3:c.862-509C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.181,\N,\N,WFS1
615272,4:6301877:C>G,NM_006005.3:c.862-507C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.946,\N,\N,WFS1
615273,4:6301883:C>T,NM_006005.3:c.862-501C>T,\N,\N,7/7,Benign,\N,intron_variant,2.911,0.0318,1KG_AFR_AF,WFS1
615274,4:6301887:G>A,NM_006005.3:c.862-497G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,4.022,0.001,1KG_SAS_AF,WFS1
615275,4:6301896:C>T,NM_006005.3:c.862-488C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.277,\N,\N,WFS1
615276,4:6301897:G>A,NM_006005.3:c.862-487G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.875,0.0015,1KG_AFR_AF,WFS1
615277,4:6301902:C>T,NM_006005.3:c.862-482C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.162,0.002,1KG_EAS_AF,WFS1
615278,4:6301907:C>T,NM_006005.3:c.862-477C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.745,0.002,1KG_SAS_AF,WFS1
615279,4:6301910:C>G,NM_006005.3:c.862-474C>G,\N,\N,7/7,Benign,\N,intron_variant,0.108,0.1033,1KG_SAS_AF,WFS1
615280,4:6301913:A>G,NM_006005.3:c.862-471A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.642,\N,\N,WFS1
615281,4:6301927:C>A,NM_006005.3:c.862-457C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,5.465,\N,\N,WFS1
615282,4:6301949:G>A,NM_006005.3:c.862-435G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.597,\N,\N,WFS1
615283,4:6301974:C>A,NM_006005.3:c.862-410C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.672,\N,\N,WFS1
615284,4:6301988:C>T,NM_006005.3:c.862-396C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.678,0.0008,1KG_AFR_AF,WFS1
615285,4:6301995:C>T,NM_006005.3:c.862-389C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.425,\N,\N,WFS1
615286,4:6302022:C>G,NM_006005.3:c.862-362C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.714,\N,\N,WFS1
615287,4:6302043:A>C,NM_006005.3:c.862-341A>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.799,\N,\N,WFS1
615288,4:6302052:A>T,NM_006005.3:c.862-332A>T,\N,\N,7/7,Benign,\N,intron_variant,1.681,0.0696,1KG_AFR_AF,WFS1
615289,4:6302063:C>G,NM_006005.3:c.862-321C>G,\N,\N,7/7,Benign,\N,intron_variant,4.074,0.0143,1KG_SAS_AF,WFS1
615290,4:6302064:C>G,NM_006005.3:c.862-320C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.786,\N,\N,WFS1
615291,4:6302064:C>T,NM_006005.3:c.862-320C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,1.795,0.001,1KG_EAS_AF,WFS1
615292,4:6302065:G>A,NM_006005.3:c.862-319G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,1.243,0.001,1KG_SAS_AF,WFS1
615293,4:6302072:C>T,NM_006005.3:c.862-312C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,6.123,0.001,1KG_SAS_AF,WFS1
615294,4:6302081:C>T,NM_006005.3:c.862-303C>T,\N,\N,7/7,Benign,\N,intron_variant,7.561,0.0091,1KG_AFR_AF,WFS1
615295,4:6302092:G>A,NM_006005.3:c.862-292G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,4.812,0.001,1KG_EUR_AF,WFS1
615296,4:6302105:C>T,NM_006005.3:c.862-279C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,8.634,\N,\N,WFS1
615297,4:6302119:G>C,NM_006005.3:c.862-265G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.497,\N,\N,WFS1
615298,4:6302120:T>C,NM_006005.3:c.862-264T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,4.691,\N,\N,WFS1
615299,4:6302123:C>T,NM_006005.3:c.862-261C>T,\N,\N,7/7,Benign,\N,intron_variant,4.997,0.0164,1KG_SAS_AF,WFS1
615300,4:6302149:A>AC,NM_006005.3:c.862-234dup,\N,\N,7/7,Benign,\N,intron_variant,2.486,0.0129,1KG_EUR_AF,WFS1
615301,4:6302150:C>T,NM_006005.3:c.862-234C>T,\N,\N,7/7,Benign,\N,intron_variant,2.917,0.0101,1KG_AMR_AF,WFS1
615302,4:6302160:G>C,NM_006005.3:c.862-224G>C,\N,\N,7/7,Benign,\N,intron_variant,0.06,0.0136,1KG_AFR_AF,WFS1
615303,4:6302164:G>A,NM_006005.3:c.862-220G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,6.355,0.001,1KG_SAS_AF,WFS1
615304,4:6302184:A>C,NM_006005.3:c.862-200A>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.492,0.0008,1KG_AFR_AF,WFS1
615305,4:6302192:CAG>C,NM_006005.3:c.862-191_862-190del,\N,\N,7/7,Unknown significance,\N,intron_variant,\N,\N,\N,WFS1
615306,4:6302199:C>T,NM_006005.3:c.862-185C>T,\N,\N,7/7,Benign,\N,intron_variant,0.478,0.9038,1KG_EAS_AF,WFS1
615307,4:6302200:G>A,NM_006005.3:c.862-184G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.059,0.0008,1KG_AFR_AF,WFS1
615308,4:6302202:G>A,NM_006005.3:c.862-182G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.657,\N,\N,WFS1
615309,4:6302210:G>T,NM_006005.3:c.862-174G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,8.875,0.001,1KG_EAS_AF,WFS1
615310,4:6302211:G>A,NM_006005.3:c.862-173G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,10.23,0.001,1KG_EAS_AF,WFS1
615311,4:6302213:G>A,NM_006005.3:c.862-171G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,10.56,0.001,1KG_EUR_AF,WFS1
615312,4:6302220:C>G,NM_006005.3:c.862-164C>G,\N,\N,7/7,Benign,\N,intron_variant,8.108,0.9038,1KG_EAS_AF,WFS1
615313,4:6302223:G>A,NM_006005.3:c.862-161G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,7.057,0.001,1KG_EAS_AF,WFS1
615314,4:6302228:G>A,NM_006005.3:c.862-156G>A,\N,\N,7/7,Benign,\N,intron_variant,6.294,0.0091,1KG_AFR_AF,WFS1
615315,4:6302229:G>A,NM_006005.3:c.862-155G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,6.103,\N,\N,WFS1
615316,4:6302229:G>C,NM_006005.3:c.862-155G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,2.132,0.0014,1KG_AMR_AF,WFS1
615317,4:6302229:G>T,NM_006005.3:c.862-155G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,3.229,\N,\N,WFS1
615318,4:6302258:G>C,NM_006005.3:c.862-126G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.191,\N,\N,WFS1
615319,4:6302266:G>A,NM_006005.3:c.862-118G>A,\N,\N,7/7,Benign,\N,intron_variant,4.203,0.0517,1KG_EUR_AF,WFS1
615320,4:6302269:A>G,NM_006005.3:c.862-115A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.852,\N,\N,WFS1
615321,4:6302279:T>C,NM_006005.3:c.862-105T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,4.258,0.0008,1KG_AFR_AF,WFS1
615322,4:6302282:G>A,NM_006005.3:c.862-102G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.533,\N,\N,WFS1
615323,4:6302288:C>A,NM_006005.3:c.862-96C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.963,0.0008,1KG_AFR_AF,WFS1
615324,4:6302303:A>G,NM_006005.3:c.862-81A>G,\N,\N,7/7,Unknown significance,\N,intron_variant,4.35,\N,\N,WFS1
615325,4:6302322:G>A,NM_006005.3:c.862-62G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.164,0.001,1KG_EUR_AF|1KG_SAS_AF,WFS1
615326,4:6302322:G>C,NM_006005.3:c.862-62G>C,\N,\N,7/7,Unknown significance,\N,intron_variant,0.027,0.003,1KG_EUR_AF,WFS1
615327,4:6302323:T>G,NM_006005.3:c.862-61T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,5.286,0.001,1KG_EAS_AF,WFS1
615328,4:6302333:G>A,NM_006005.3:c.862-51G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,5.988,0.0000153965,EXAC_NFE_AF,WFS1
615329,4:6302337:T>C,NM_006005.3:c.862-47T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,3.76,0.000453926,EVS_AA_AF,WFS1
615330,4:6302337:T>TG,NM_006005.3:c.862-42dup,\N,\N,7/7,Unknown significance,\N,intron_variant,4.488,0.000299222,EXAC_AFR_AF,WFS1
615331,4:6302338:G>A,NM_006005.3:c.862-46G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,6.444,0.001,1KG_EUR_AF,WFS1
615332,4:6302340:G>T,NM_006005.3:c.862-44G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.02,0.0000619425,EXAC_SAS_AF,WFS1
615333,4:6302341:G>T,NM_006005.3:c.862-43G>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.923,\N,\N,WFS1
615334,4:6302345:C>A,NM_006005.3:c.862-39C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.954,0.00011685,EXAC_EAS_AF,WFS1
615335,4:6302348:T>C,NM_006005.3:c.862-36T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.056,0.000116768,EXAC_EAS_AF,WFS1
615336,4:6302350:C>T,NM_006005.3:c.862-34C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,5.23,0.0000152812,EXAC_NFE_AF,WFS1
615337,4:6302351:C>T,NM_006005.3:c.862-33C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.468,0.0000989903,EXAC_AFR_AF,WFS1
615338,4:6302353:G>A,NM_006005.3:c.862-31G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,6.395,0.00151515,EXAC_EAS_AF,WFS1
615339,4:6302355:C>A,NM_006005.3:c.862-29C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,5.542,0.000156544,EXAC_FIN_AF,WFS1
615340,4:6302357:C>G,NM_006005.3:c.862-27C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,2.399,0.0000152096,EXAC_NFE_AF,WFS1
615341,4:6302357:C>T,NM_006005.3:c.862-27C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,4.223,0.0000884486,EXAC_AMR_AF,WFS1
615342,4:6302358:G>A,NM_006005.3:c.862-26G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,3.786,0.000369686,EXAC_SAS_AF,WFS1
615343,4:6302359:T>C,NM_006005.3:c.862-25T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,4.306,0.003,1KG_EAS_AF,WFS1
615344,4:6302365:C>T,NM_006005.3:c.862-19C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,0.993,0.00068089,EVS_AA_AF,WFS1
615345,4:6302366:G>A,NM_006005.3:c.862-18G>A,\N,\N,7/7,Unknown significance,\N,intron_variant,0.152,0.000061282,EXAC_SAS_AF,WFS1
615346,4:6302367:T>C,NM_006005.3:c.862-17T>C,\N,\N,7/7,Unknown significance,\N,intron_variant,1.345,0.0000612595,EXAC_SAS_AF,WFS1
615347,4:6302370:C>T,NM_006005.3:c.862-14C>T,\N,\N,7/7,Unknown significance,\N,intron_variant,2.383,0.0000150957,EXAC_NFE_AF,WFS1
615348,4:6302373:C>A,NM_006005.3:c.862-11C>A,\N,\N,7/7,Unknown significance,\N,intron_variant,2.141,0.000226963,EVS_AA_AF,WFS1
615349,4:6302373:C>G,NM_006005.3:c.862-11C>G,\N,\N,7/7,Unknown significance,\N,intron_variant,0.71,0.000015082,EXAC_NFE_AF,WFS1
615350,4:6302374:T>G,NM_006005.3:c.862-10T>G,\N,\N,7/7,Unknown significance,\N,intron_variant,1.313,0.000226963,EVS_AA_AF,WFS1
615351,4:6302378:C>T,NM_006005.3:c.862-6C>T,\N,\N,7/7,Unknown significance,\N,splice_region_variant&intron_variant,4.544,0.0000150553,EXAC_NFE_AF,WFS1
615352,4:6302379:C>T,NM_006005.3:c.862-5C>T,\N,\N,7/7,Unknown significance,\N,splice_region_variant&intron_variant,1.005,0.0000150521,EXAC_NFE_AF,WFS1
615353,4:6302381:C>G,NM_006005.3:c.862-3C>G,\N,\N,7/7,Unknown significance,\N,splice_region_variant&intron_variant,0.302,0.001,1KG_EUR_AF,WFS1
615354,4:6302384:G>A,NM_006005.3:c.862G>A,NP_005996.2:p.Val288Met,8/8,\N,Likely pathogenic,\N,missense_variant&splice_region_variant,0.229,\N,\N,WFS1
615355,4:6302385:T>G,NM_006005.3:c.863T>G,NP_005996.2:p.Val288Gly,8/8,\N,Unknown significance,\N,missense_variant&splice_region_variant,15.68,0.0000150353,EXAC_NFE_AF,WFS1
615356,4:6302387:G>T,NM_006005.3:c.865G>T,NP_005996.2:p.Val289Phe,8/8,\N,Benign,\N,missense_variant,4.916,0.005,OTO_TR_AF,WFS1
615357,4:6302394:A>AC,NM_006005.3:c.877dup,NP_005996.2:p.Leu293ProfsTer13,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,24.1,\N,\N,WFS1
615358,4:6302394:AC>A,NM_006005.3:c.877del,NP_005996.2:p.Leu293CysfsTer11,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,23,\N,\N,WFS1
615359,4:6302394:A>C,NM_006005.3:c.872A>C,NP_005996.2:p.Tyr291Ser,8/8,\N,Unknown significance,\N,missense_variant,22.3,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
615360,4:6302395:C>G,NM_006005.3:c.873C>G,NP_005996.2:p.Tyr291Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,34,\N,\N,WFS1
615361,4:6302395:C>T,NM_006005.3:c.873C>T,NP_005996.2:p.Tyr291=,8/8,\N,Unknown significance,\N,synonymous_variant,0.006,0.0000869263,EXAC_AMR_AF,WFS1
615362,4:6302395:C>A,NM_006005.3:c.873C>A,NP_005996.2:p.Tyr291Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,34,\N,\N,WFS1
615363,4:6302396:C>A,NM_006005.3:c.874C>A,NP_005996.2:p.Pro292Thr,8/8,\N,Unknown significance,\N,missense_variant,24.1,0.0000300237,EXAC_NFE_AF,WFS1
615364,4:6302396:C>T,NM_006005.3:c.874C>T,NP_005996.2:p.Pro292Ser,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.2,0.0000150119,EXAC_NFE_AF,WFS1
615365,4:6302403:A>T,NM_006005.3:c.881A>T,NP_005996.2:p.His294Leu,8/8,\N,Unknown significance,\N,missense_variant,15.25,\N,\N,WFS1
615366,4:6302404:C>A,NM_006005.3:c.882C>A,NP_005996.2:p.His294Gln,8/8,\N,Unknown significance,\N,missense_variant,16,0.0000962835,EXAC_AFR_AF,WFS1
615367,4:6302404:C>T,NM_006005.3:c.882C>T,NP_005996.2:p.His294=,8/8,\N,Unknown significance,\N,synonymous_variant,4.956,0.001,1KG_SAS_AF,WFS1
615368,4:6302405:G>A,NM_006005.3:c.883G>A,NP_005996.2:p.Ala295Thr,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.0000150033,EXAC_NFE_AF,WFS1
615369,4:6302407:C>T,NM_006005.3:c.885C>T,NP_005996.2:p.Ala295=,8/8,\N,Unknown significance,\N,synonymous_variant,4.981,0.001,1KG_EAS_AF,WFS1
615370,4:6302409:T>G,NM_006005.3:c.887T>G,NP_005996.2:p.Ile296Ser,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.9,\N,\N,WFS1
615371,4:6302410:C>A,NM_006005.3:c.888C>A,NP_005996.2:p.Ile296=,8/8,\N,Unknown significance,\N,synonymous_variant,12.04,0.000115607,EXAC_EAS_AF,WFS1
615372,4:6302412:T>A,NM_006005.3:c.890T>A,NP_005996.2:p.Met297Lys,8/8,\N,Unknown significance,\N,missense_variant,15.51,0.0000149939,EXAC_NFE_AF,WFS1
615373,4:6302414:G>C,NM_006005.3:c.892G>C,NP_005996.2:p.Glu298Gln,8/8,\N,Unknown significance,\N,missense_variant,22.7,0.0000605914,EXAC_SAS_AF,WFS1
615374,4:6302415:A>C,NM_006005.3:c.893A>C,NP_005996.2:p.Glu298Ala,8/8,\N,Unknown significance,\N,missense_variant,14.88,0.00011558,EXAC_EAS_AF,WFS1
615375,4:6302416:G>A,NM_006005.3:c.894G>A,NP_005996.2:p.Glu298=,8/8,\N,Unknown significance,\N,synonymous_variant,2.626,0.000226963,EVS_AA_AF,WFS1
615376,4:6302417:A>G,NM_006005.3:c.895A>G,NP_005996.2:p.Ile299Val,8/8,\N,Likely benign,\N,missense_variant,0.144,0.00017316,EXAC_AMR_AF,WFS1
615377,4:6302419:C>G,NM_006005.3:c.897C>G,NP_005996.2:p.Ile299Met,8/8,\N,Likely benign,\N,missense_variant,8.611,\N,\N,WFS1
615378,4:6302420:A>G,NM_006005.3:c.898A>G,NP_005996.2:p.Lys300Glu,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.000014993,EXAC_NFE_AF,WFS1
615379,4:6302428:C>T,NM_006005.3:c.906C>T,NP_005996.2:p.Tyr302=,8/8,\N,Unknown significance,\N,synonymous_variant,3.07,0.000121183,EXAC_SAS_AF,WFS1
615380,4:6302428:C>A,NM_006005.3:c.906C>A,NP_005996.2:p.Tyr302Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,35,\N,\N,WFS1
615381,4:6302429:C>CTGAT,NM_006005.3:c.911_914dup,NP_005996.2:p.Met306Ter,8/8,\N,Pathogenic,\N,frameshift_variant,\N,\N,\N,WFS1
615382,4:6302429:C>A,NM_006005.3:c.907C>A,NP_005996.2:p.Leu303Met,8/8,\N,Unknown significance,\N,missense_variant,23.4,0.0000149876,EXAC_NFE_AF,WFS1
615383,4:6302430:T>C,NM_006005.3:c.908T>C,NP_005996.2:p.Leu303Pro,8/8,\N,Pathogenic,Deafness,missense_variant,24.7,\N,\N,WFS1
615384,4:6302431:G>A,NM_006005.3:c.909G>A,NP_005996.2:p.Leu303=,8/8,\N,Unknown significance,\N,synonymous_variant,1.836,0.00007494,EXAC_NFE_AF,WFS1
615385,4:6302431:G>C,NM_006005.3:c.909G>C,NP_005996.2:p.Leu303=,8/8,\N,Unknown significance,\N,synonymous_variant,0.94,0.00007494,EXAC_NFE_AF,WFS1
615386,4:6302435:G>T,NM_006005.3:c.913G>T,NP_005996.2:p.Asp305Tyr,8/8,\N,Unknown significance,\N,missense_variant,22.9,0.0000605767,EXAC_SAS_AF,WFS1
615387,4:6302437:C>T,NM_006005.3:c.915C>T,NP_005996.2:p.Asp305=,8/8,\N,Unknown significance,\N,synonymous_variant,3.498,0.000192271,EXAC_AFR_AF,WFS1
615388,4:6302439:T>C,NM_006005.3:c.917T>C,NP_005996.2:p.Met306Thr,8/8,\N,Benign,\N,missense_variant,4.335,0.0144,1KG_AFR_AF,WFS1
615389,4:6302442:C>T,NM_006005.3:c.920C>T,NP_005996.2:p.Ala307Val,8/8,\N,Unknown significance,\N,missense_variant,23.7,0.000116279,EVS_EA_AF,WFS1
615390,4:6302443:C>T,NM_006005.3:c.921C>T,NP_005996.2:p.Ala307=,8/8,\N,Unknown significance,\N,synonymous_variant,10.01,0.0000149867,EXAC_NFE_AF,WFS1
615391,4:6302444:T>G,NM_006005.3:c.922T>G,NP_005996.2:p.Ser308Ala,8/8,\N,Unknown significance,\N,missense_variant,22.9,0.000172861,EXAC_AMR_AF,WFS1
615392,4:6302446:C>A,NM_006005.3:c.924C>A,NP_005996.2:p.Ser308=,8/8,\N,Unknown significance,\N,synonymous_variant,9.527,\N,\N,WFS1
615393,4:6302446:C>T,NM_006005.3:c.924C>T,NP_005996.2:p.Ser308=,8/8,\N,Unknown significance,\N,synonymous_variant,6.704,0.000151423,EXAC_FIN_AF,WFS1
615394,4:6302448:G>A,NM_006005.3:c.926G>A,NP_005996.2:p.Arg309Lys,8/8,\N,Likely benign,\N,missense_variant,6.417,0.001,1KG_SAS_AF,WFS1
615395,4:6302449:G>C,NM_006005.3:c.927G>C,NP_005996.2:p.Arg309Ser,8/8,\N,Likely benign,\N,missense_variant,15.5,0.0000149853,EXAC_NFE_AF,WFS1
615396,4:6302450:G>C,NM_006005.3:c.928G>C,NP_005996.2:p.Ala310Pro,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.0000149853,EXAC_NFE_AF,WFS1
615397,4:6302451:C>T,NM_006005.3:c.929C>T,NP_005996.2:p.Ala310Val,8/8,\N,Unknown significance,\N,missense_variant,24,0.000226963,EVS_AA_AF,WFS1
615398,4:6302452:A>G,NM_006005.3:c.930A>G,NP_005996.2:p.Ala310=,8/8,\N,Benign,\N,synonymous_variant,0.699,0.034,1KG_AFR_AF,WFS1
615399,4:6302455:C>T,NM_006005.3:c.933C>T,NP_005996.2:p.Gly311=,8/8,\N,Unknown significance,\N,synonymous_variant,8.103,0.0000960984,EXAC_AFR_AF,WFS1
615400,4:6302456:A>G,NM_006005.3:c.934A>G,NP_005996.2:p.Met312Val,8/8,\N,Unknown significance,\N,missense_variant,0.048,\N,\N,WFS1
615401,4:6302456:A>ATGCAC,NM_006005.3:c.937_941dup,NP_005996.2:p.Trp314CysfsTer47,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,27.5,\N,\N,WFS1
615402,4:6302457:T>G,NM_006005.3:c.935T>G,NP_005996.2:p.Met312Arg,8/8,\N,Unknown significance,\N,missense_variant,22.3,\N,\N,WFS1
615403,4:6302459:C>T,NM_006005.3:c.937C>T,NP_005996.2:p.His313Tyr,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23,\N,\N,WFS1
615404,4:6302461:C>G,NM_006005.3:c.939C>G,NP_005996.2:p.His313Gln,8/8,\N,Unknown significance,\N,missense_variant,14.3,0.000115554,EXAC_EAS_AF,WFS1
615405,4:6302462:T>C,NM_006005.3:c.940T>C,NP_005996.2:p.Trp314Arg,8/8,\N,Pathogenic,Diabetes,missense_variant,24.4,\N,\N,WFS1
615406,4:6302465:C>T,NM_006005.3:c.943C>T,NP_005996.2:p.Leu315=,8/8,\N,Unknown significance,\N,synonymous_variant,7.158,0.0000149849,EXAC_NFE_AF,WFS1
615407,4:6302468:TCCA>T,NM_006005.3:c.950_952del,NP_005996.2:p.Thr317del,8/8,\N,Unknown significance,\N,inframe_deletion,12.74,\N,\N,WFS1
615408,4:6302469:C>G,NM_006005.3:c.947C>G,NP_005996.2:p.Ser316Cys,8/8,\N,Unknown significance,\N,missense_variant,23.9,\N,\N,WFS1
615409,4:6302470:C>T,NM_006005.3:c.948C>T,NP_005996.2:p.Ser316=,8/8,\N,Unknown significance,\N,synonymous_variant,1.699,0.00011558,EXAC_EAS_AF,WFS1
615410,4:6302472:C>G,NM_006005.3:c.950C>G,NP_005996.2:p.Thr317Ser,8/8,\N,Likely benign,\N,missense_variant,6.136,0.000346741,EXAC_EAS_AF,WFS1
615411,4:6302473:C>A,NM_006005.3:c.951C>A,NP_005996.2:p.Thr317=,8/8,\N,Unknown significance,\N,synonymous_variant,9.873,0.000115554,EXAC_EAS_AF,WFS1
615412,4:6302473:C>T,NM_006005.3:c.951C>T,NP_005996.2:p.Thr317=,8/8,\N,Unknown significance,\N,synonymous_variant,2.965,0.00277778,OTO_ES_AF,WFS1
615413,4:6302482:C>T,NM_006005.3:c.960C>T,NP_005996.2:p.Pro320=,8/8,\N,Unknown significance,\N,synonymous_variant,6.13,0.000226963,EVS_AA_AF,WFS1
615414,4:6302484:C>T,NM_006005.3:c.962C>T,NP_005996.2:p.Thr321Met,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,28,0.0000149844,EXAC_NFE_AF,WFS1
615415,4:6302485:G>A,NM_006005.3:c.963G>A,NP_005996.2:p.Thr321=,8/8,\N,Unknown significance,\N,synonymous_variant,8.3,0.00110132,EXAC_OTH_AF,WFS1
615416,4:6302485:GCAC>G,NM_006005.3:c.967_969del,NP_005996.2:p.His323del,8/8,\N,Unknown significance,\N,inframe_deletion,17.67,0.000288295,EXAC_AFR_AF,WFS1
615417,4:6302488:C>G,NM_006005.3:c.966C>G,NP_005996.2:p.His322Gln,8/8,\N,Likely benign,\N,missense_variant,5.892,0.0000960984,EXAC_AFR_AF,WFS1
615418,4:6302488:C>T,NM_006005.3:c.966C>T,NP_005996.2:p.His322=,8/8,\N,Unknown significance,\N,synonymous_variant,6.752,0.003,1KG_AFR_AF,WFS1
615419,4:6302491:C>T,NM_006005.3:c.969C>T,NP_005996.2:p.His323=,8/8,\N,Unknown significance,\N,synonymous_variant,6.652,0.000014984,EXAC_NFE_AF,WFS1
615420,4:6302492:A>C,NM_006005.3:c.970A>C,NP_005996.2:p.Ile324Leu,8/8,\N,Unknown significance,\N,missense_variant,8.732,0.0008,1KG_AFR_AF,WFS1
615421,4:6302496:A>G,NM_006005.3:c.974A>G,NP_005996.2:p.Asn325Ser,8/8,\N,Unknown significance,\N,missense_variant,22.5,0.000115554,EXAC_EAS_AF,WFS1
615422,4:6302497:C>T,NM_006005.3:c.975C>T,NP_005996.2:p.Asn325=,8/8,\N,Unknown significance,\N,synonymous_variant,10.43,0.001,1KG_SAS_AF,WFS1
615423,4:6302498:G>A,NM_006005.3:c.976G>A,NP_005996.2:p.Ala326Thr,8/8,\N,Unknown significance,\N,missense_variant,23.7,0.000345543,EXAC_AMR_AF,WFS1
615424,4:6302498:G>T,NM_006005.3:c.976G>T,NP_005996.2:p.Ala326Ser,8/8,\N,Unknown significance,\N,missense_variant,23.4,0.001,1KG_EAS_AF,WFS1
615425,4:6302499:C>G,NM_006005.3:c.977C>G,NP_005996.2:p.Ala326Gly,8/8,\N,Unknown significance,\N,missense_variant,24.1,0.0000863856,EXAC_AMR_AF,WFS1
615426,4:6302499:C>T,NM_006005.3:c.977C>T,NP_005996.2:p.Ala326Val,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.000226963,EVS_AA_AF,WFS1
615427,4:6302500:G>A,NM_006005.3:c.978G>A,NP_005996.2:p.Ala326=,8/8,\N,Benign,\N,synonymous_variant,7.706,0.005,OTO_TR_AF,WFS1
615428,4:6302501:C>A,NM_006005.3:c.979C>A,NP_005996.2:p.Leu327Ile,8/8,\N,Unknown significance,\N,missense_variant,26.5,0.000116279,EVS_EA_AF,WFS1
615429,4:6302507:T>A,NM_006005.3:c.985T>A,NP_005996.2:p.Phe329Ile,8/8,\N,Unknown significance,\N,missense_variant,25.2,0.002,1KG_EAS_AF,WFS1
615430,4:6302509:C>T,NM_006005.3:c.987C>T,NP_005996.2:p.Phe329=,8/8,\N,Unknown significance,\N,synonymous_variant,9.687,\N,\N,WFS1
615431,4:6302513:T>A,NM_006005.3:c.991T>A,NP_005996.2:p.Phe331Ile,8/8,\N,Unknown significance,\N,missense_variant,18.64,0.000777336,EXAC_AMR_AF,WFS1
615432,4:6302515:C>T,NM_006005.3:c.993C>T,NP_005996.2:p.Phe331=,8/8,\N,Unknown significance,\N,synonymous_variant,8.164,0.0000149844,EXAC_NFE_AF,WFS1
615433,4:6302516:A>G,NM_006005.3:c.994A>G,NP_005996.2:p.Ile332Val,8/8,\N,Unknown significance,\N,missense_variant,8.965,0.0008,1KG_AFR_AF,WFS1
615434,4:6302517:T>C,NM_006005.3:c.995T>C,NP_005996.2:p.Ile332Thr,8/8,\N,Unknown significance,\N,missense_variant,24,0.0000149858,EXAC_NFE_AF,WFS1
615435,4:6302518:C>A,NM_006005.3:c.996C>A,NP_005996.2:p.Ile332=,8/8,\N,Unknown significance,\N,synonymous_variant,15.76,0.000226963,EVS_AA_AF,WFS1
615436,4:6302518:C>T,NM_006005.3:c.996C>T,NP_005996.2:p.Ile332=,8/8,\N,Unknown significance,\N,synonymous_variant,11.62,0.0008,1KG_AFR_AF,WFS1
615437,4:6302519:G>A,NM_006005.3:c.997G>A,NP_005996.2:p.Val333Ile,8/8,\N,Benign,\N,missense_variant,5.055,0.99792,EXAC_EAS_AF,WFS1
615438,4:6302519:G>T,NM_006005.3:c.997G>T,NP_005996.2:p.Val333Phe,8/8,\N,Benign,\N,missense_variant,16.52,\N,\N,WFS1
615439,4:6302523:G>A,NM_006005.3:c.1001G>A,NP_005996.2:p.Ser334Asn,8/8,\N,Unknown significance,\N,missense_variant,24.7,0.000060562,EXAC_SAS_AF,WFS1
615440,4:6302528:C>T,NM_006005.3:c.1006C>T,NP_005996.2:p.Leu336Phe,8/8,\N,Unknown significance,\N,missense_variant,23.9,\N,\N,WFS1
615441,4:6302530:C>G,NM_006005.3:c.1008C>G,NP_005996.2:p.Leu336=,8/8,\N,Unknown significance,\N,synonymous_variant,1.406,0.0000299679,EXAC_NFE_AF,WFS1
615442,4:6302531:A>C,NM_006005.3:c.1009A>C,NP_005996.2:p.Thr337Pro,8/8,\N,Benign,\N,missense_variant,24.2,0.01,OTO_TR_AF,WFS1
615443,4:6302534:A>G,NM_006005.3:c.1012A>G,NP_005996.2:p.Ile338Val,8/8,\N,Likely benign,\N,missense_variant,3.062,0.001,1KG_SAS_AF,WFS1
615444,4:6302536:C>G,NM_006005.3:c.1014C>G,NP_005996.2:p.Ile338Met,8/8,\N,Unknown significance,\N,missense_variant,23,0.000014984,EXAC_NFE_AF,WFS1
615445,4:6302537:G>A,NM_006005.3:c.1015G>A,NP_005996.2:p.Asp339Asn,8/8,\N,Likely benign,\N,missense_variant,28.1,0.0000149849,EXAC_NFE_AF,WFS1
615446,4:6302538:ACTT>A,NM_006005.3:c.1021_1023del,NP_005996.2:p.Phe341del,8/8,\N,Unknown significance,\N,inframe_deletion,13.93,0.0000149844,EXAC_NFE_AF,WFS1
615447,4:6302538:A>ACTTCTTCGC,NM_006005.3:c.1024_1032dup,NP_005996.2:p.Ala342_Phe344dup,8/8,\N,Pathogenic,Wolfram syndrome,inframe_insertion,9.858,\N,\N,WFS1
615448,4:6302545:C>T,NM_006005.3:c.1023C>T,NP_005996.2:p.Phe341=,8/8,\N,Benign,\N,synonymous_variant,11.97,0.145,OTO_AJ_AF,WFS1
615449,4:6302546:G>A,NM_006005.3:c.1024G>A,NP_005996.2:p.Ala342Thr,8/8,\N,Benign,\N,missense_variant,19.77,0.005,OTO_TR_AF,WFS1
615450,4:6302546:G>C,NM_006005.3:c.1024G>C,NP_005996.2:p.Ala342Pro,8/8,\N,Unknown significance,\N,missense_variant,24,0.0000961169,EXAC_AFR_AF,WFS1
615451,4:6302548:C>T,NM_006005.3:c.1026C>T,NP_005996.2:p.Ala342=,8/8,\N,Unknown significance,\N,synonymous_variant,11.08,0.0000149835,EXAC_NFE_AF,WFS1
615452,4:6302550:T>TC,NM_006005.3:c.1029dup,NP_005996.2:p.Phe344LeufsTer199,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,33,\N,\N,WFS1
615453,4:6302551:C>T,NM_006005.3:c.1029C>T,NP_005996.2:p.Phe343=,8/8,\N,Unknown significance,\N,synonymous_variant,9.624,0.000259112,EXAC_AMR_AF,WFS1
615454,4:6302554:C>T,NM_006005.3:c.1032C>T,NP_005996.2:p.Phe344=,8/8,\N,Unknown significance,\N,synonymous_variant,8.075,\N,\N,WFS1
615455,4:6302556:T>TC,NM_006005.3:c.1037dup,NP_005996.2:p.Leu347AlafsTer196,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,33,\N,\N,WFS1
615456,4:6302559:C>T,NM_006005.3:c.1037C>T,NP_005996.2:p.Pro346Leu,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.8,0.000151194,EXAC_FIN_AF,WFS1
615457,4:6302560:G>A,NM_006005.3:c.1038G>A,NP_005996.2:p.Pro346=,8/8,\N,Unknown significance,\N,synonymous_variant,7.621,0.0023,1KG_AFR_AF,WFS1
615458,4:6302563:G>A,NM_006005.3:c.1041G>A,NP_005996.2:p.Leu347=,8/8,\N,Unknown significance,\N,synonymous_variant,3.308,0.001,1KG_SAS_AF,WFS1
615459,4:6302566:C>G,NM_006005.3:c.1044C>G,NP_005996.2:p.Val348=,8/8,\N,Unknown significance,\N,synonymous_variant,1.815,0.00014984,EXAC_NFE_AF,WFS1
615460,4:6302567:ATCT>A,NM_006005.3:c.1049_1051del,NP_005996.2:p.Phe350del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,14.91,\N,\N,WFS1
615461,4:6302569:C>T,NM_006005.3:c.1047C>T,NP_005996.2:p.Ile349=,8/8,\N,Unknown significance,\N,synonymous_variant,10.78,0.0000961169,EXAC_AFR_AF,WFS1
615462,4:6302570:T>G,NM_006005.3:c.1048T>G,NP_005996.2:p.Phe350Val,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.5,\N,\N,WFS1
615463,4:6302571:TCTAC>T,NM_006005.3:c.1052_1055del,NP_005996.2:p.Tyr351CysfsTer7,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,33,\N,\N,WFS1
615464,4:6302572:C>G,NM_006005.3:c.1050C>G,NP_005996.2:p.Phe350Leu,8/8,\N,Unknown significance,\N,missense_variant,26.2,0.002,1KG_SAS_AF,WFS1
615465,4:6302574:A>G,NM_006005.3:c.1052A>G,NP_005996.2:p.Tyr351Cys,8/8,\N,Unknown significance,\N,missense_variant,25.4,0.001,1KG_EUR_AF,WFS1
615466,4:6302580:C>G,NM_006005.3:c.1058C>G,NP_005996.2:p.Ser353Cys,8/8,\N,Unknown significance,\N,missense_variant,25.4,0.000116279,EVS_EA_AF,WFS1
615467,4:6302580:CCTT>C,NM_006005.3:c.1060_1062del,NP_005996.2:p.Phe354del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,14.42,\N,\N,WFS1
615468,4:6302580:C>T,NM_006005.3:c.1058C>T,NP_005996.2:p.Ser353Phe,8/8,\N,Likely pathogenic,Cerebellar ataxia,missense_variant,27.2,\N,\N,WFS1
615469,4:6302581:C>T,NM_006005.3:c.1059C>T,NP_005996.2:p.Ser353=,8/8,\N,Unknown significance,\N,synonymous_variant,9.374,0.0000863856,EXAC_AMR_AF,WFS1
615470,4:6302586:T>G,NM_006005.3:c.1064T>G,NP_005996.2:p.Ile355Ser,8/8,\N,Unknown significance,\N,missense_variant,23.2,0.000060562,EXAC_SAS_AF,WFS1
615471,4:6302587:C>A,NM_006005.3:c.1065C>A,NP_005996.2:p.Ile355=,8/8,\N,Unknown significance,\N,synonymous_variant,14.46,0.0000863707,EXAC_AMR_AF,WFS1
615472,4:6302590:C>T,NM_006005.3:c.1068C>T,NP_005996.2:p.Ser356=,8/8,\N,Unknown significance,\N,synonymous_variant,9.276,0.000115554,EXAC_EAS_AF,WFS1
615473,4:6302601:G>A,NM_006005.3:c.1079G>A,NP_005996.2:p.Cys360Tyr,8/8,\N,Unknown significance,\N,missense_variant,25,0.000226963,EVS_AA_AF,WFS1
615474,4:6302602:C>T,NM_006005.3:c.1080C>T,NP_005996.2:p.Cys360=,8/8,\N,Unknown significance,\N,synonymous_variant,1.167,0.0000863707,EXAC_AMR_AF,WFS1
615475,4:6302604:C>T,NM_006005.3:c.1082C>T,NP_005996.2:p.Thr361Ile,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.9,0.000431854,EXAC_AMR_AF,WFS1
615476,4:6302606:C>G,NM_006005.3:c.1084C>G,NP_005996.2:p.Leu362Val,8/8,\N,Unknown significance,\N,missense_variant,22.7,0.0000149844,EXAC_NFE_AF,WFS1
615477,4:6302606:C>T,NM_006005.3:c.1084C>T,NP_005996.2:p.Leu362Phe,8/8,\N,Unknown significance,\N,missense_variant,22.8,0.0000149844,EXAC_NFE_AF,WFS1
615478,4:6302608:C>G,NM_006005.3:c.1086C>G,NP_005996.2:p.Leu362=,8/8,\N,Unknown significance,\N,synonymous_variant,0.187,0.000226963,EVS_AA_AF,WFS1
615479,4:6302615:T>G,NM_006005.3:c.1093T>G,NP_005996.2:p.Phe365Val,8/8,\N,Unknown significance,\N,missense_variant,24.3,\N,\N,WFS1
615480,4:6302618:C>T,NM_006005.3:c.1096C>T,NP_005996.2:p.Gln366Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,37,0.0000961169,EXAC_AFR_AF,WFS1
615481,4:6302622:A>G,NM_006005.3:c.1100A>G,NP_005996.2:p.Asp367Gly,8/8,\N,Unknown significance,\N,missense_variant,10.68,0.0000299679,EXAC_NFE_AF,WFS1
615482,4:6302624:A>AGCAAG,NM_006005.3:c.1105_1109dup,NP_005996.2:p.Trp371ArgfsTer73,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,27.1,\N,\N,WFS1
615483,4:6302625:G>A,NM_006005.3:c.1103G>A,NP_005996.2:p.Ser368Asn,8/8,\N,Unknown significance,\N,missense_variant,14.48,0.0000299679,EXAC_NFE_AF,WFS1
615484,4:6302626:C>G,NM_006005.3:c.1104C>G,NP_005996.2:p.Ser368Arg,8/8,\N,Unknown significance,\N,missense_variant,22.9,0.0000299679,EXAC_NFE_AF,WFS1
615485,4:6302628:A>C,NM_006005.3:c.1106A>C,NP_005996.2:p.Lys369Thr,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.0000863707,EXAC_AMR_AF,WFS1
615486,4:6302630:G>A,NM_006005.3:c.1108G>A,NP_005996.2:p.Ala370Thr,8/8,\N,Unknown significance,\N,missense_variant,24.2,0.000014984,EXAC_NFE_AF,WFS1
615487,4:6302634:G>A,NM_006005.3:c.1112G>A,NP_005996.2:p.Trp371Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,37,\N,\N,WFS1
615488,4:6302635:G>A,NM_006005.3:c.1113G>A,NP_005996.2:p.Trp371Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,37,\N,\N,WFS1
615489,4:6302640:A>G,NM_006005.3:c.1118A>G,NP_005996.2:p.Asn373Ser,8/8,\N,Likely benign,\N,missense_variant,8.476,0.0000299679,EXAC_NFE_AF,WFS1
615490,4:6302641:C>A,NM_006005.3:c.1119C>A,NP_005996.2:p.Asn373Lys,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.000014984,EXAC_NFE_AF,WFS1
615491,4:6302641:C>G,NM_006005.3:c.1119C>G,NP_005996.2:p.Asn373Lys,8/8,\N,Unknown significance,\N,missense_variant,23.1,0.000014984,EXAC_NFE_AF,WFS1
615492,4:6302645:C>T,NM_006005.3:c.1123C>T,NP_005996.2:p.Arg375Cys,8/8,\N,Likely pathogenic,\N,missense_variant,31,0.000480584,EXAC_AFR_AF,WFS1
615493,4:6302645:C>A,NM_006005.3:c.1123C>A,NP_005996.2:p.Arg375Ser,8/8,\N,Unknown significance,\N,missense_variant,27.2,0.0000961169,EXAC_AFR_AF,WFS1
615494,4:6302646:G>A,NM_006005.3:c.1124G>A,NP_005996.2:p.Arg375His,8/8,\N,Unknown significance,\N,missense_variant,26.3,0.000465116,EVS_EA_AF,WFS1
615495,4:6302647:C>T,NM_006005.3:c.1125C>T,NP_005996.2:p.Arg375=,8/8,\N,Unknown significance,\N,synonymous_variant,8.78,0.0000299679,EXAC_NFE_AF,WFS1
615496,4:6302648:A>C,NM_006005.3:c.1126A>C,NP_005996.2:p.Thr376Pro,8/8,\N,Benign,\N,missense_variant,19.32,0.02,OTO_TR_AF,WFS1
615497,4:6302649:C>T,NM_006005.3:c.1127C>T,NP_005996.2:p.Thr376Ile,8/8,\N,Unknown significance,\N,missense_variant,23,0.000060562,EXAC_SAS_AF,WFS1
615498,4:6302651:C>G,NM_006005.3:c.1129C>G,NP_005996.2:p.Leu377Val,8/8,\N,Unknown significance,\N,missense_variant,22.9,\N,\N,WFS1
615499,4:6302654:A>T,NM_006005.3:c.1132A>T,NP_005996.2:p.Thr378Ser,8/8,\N,Unknown significance,\N,missense_variant,16.26,0.000014984,EXAC_NFE_AF,WFS1
615500,4:6302656:C>A,NM_006005.3:c.1134C>A,NP_005996.2:p.Thr378=,8/8,\N,Benign,\N,synonymous_variant,12.53,0.0613,1KG_SAS_AF,WFS1
615501,4:6302656:C>G,NM_006005.3:c.1134C>G,NP_005996.2:p.Thr378=,8/8,\N,Unknown significance,\N,synonymous_variant,5.39,0.000434535,EXAC_NFE_AF,WFS1
615502,4:6302656:C>T,NM_006005.3:c.1134C>T,NP_005996.2:p.Thr378=,8/8,\N,Unknown significance,\N,synonymous_variant,9.258,0.0000961169,EXAC_AFR_AF,WFS1
615503,4:6302657:G>A,NM_006005.3:c.1135G>A,NP_005996.2:p.Asp379Asn,8/8,\N,Likely benign,\N,missense_variant,10.46,0.000242248,EXAC_SAS_AF,WFS1
615504,4:6302659:C>G,NM_006005.3:c.1137C>G,NP_005996.2:p.Asp379Glu,8/8,\N,Likely benign,\N,missense_variant,5.593,0.000060562,EXAC_SAS_AF,WFS1
615505,4:6302664:T>C,NM_006005.3:c.1142T>C,NP_005996.2:p.Leu381Pro,8/8,\N,Unknown significance,\N,missense_variant,25.3,\N,\N,WFS1
615506,4:6302665:G>A,NM_006005.3:c.1143G>A,NP_005996.2:p.Leu381=,8/8,\N,Unknown significance,\N,synonymous_variant,1.716,0.003,1KG_AFR_AF,WFS1
615507,4:6302666:C>T,NM_006005.3:c.1144C>T,NP_005996.2:p.Leu382=,8/8,\N,Unknown significance,\N,synonymous_variant,6.831,0.0043,1KG_AMR_AF,WFS1
615508,4:6302667:T>C,NM_006005.3:c.1145T>C,NP_005996.2:p.Leu382Pro,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.5,\N,\N,WFS1
615509,4:6302669:C>T,NM_006005.3:c.1147C>T,NP_005996.2:p.Arg383Cys,8/8,\N,Unknown significance,\N,missense_variant,27.1,0.003125,OTO_US_AF,WFS1
615510,4:6302670:G>A,NM_006005.3:c.1148G>A,NP_005996.2:p.Arg383His,8/8,\N,Unknown significance,\N,missense_variant,18,0.0041,1KG_SAS_AF,WFS1
615511,4:6302670:G>C,NM_006005.3:c.1148G>C,NP_005996.2:p.Arg383Pro,8/8,\N,Unknown significance,\N,missense_variant,24.4,0.000014984,EXAC_NFE_AF,WFS1
615512,4:6302670:G>T,NM_006005.3:c.1148G>T,NP_005996.2:p.Arg383Leu,8/8,\N,Unknown significance,\N,missense_variant,24.1,0.000014984,EXAC_NFE_AF,WFS1
615513,4:6302674:C>T,NM_006005.3:c.1152C>T,NP_005996.2:p.Phe384=,8/8,\N,Likely benign,\N,synonymous_variant,11.61,0.00207996,EXAC_EAS_AF,WFS1
615514,4:6302675:G>A,NM_006005.3:c.1153G>A,NP_005996.2:p.Glu385Lys,8/8,\N,Benign,\N,missense_variant,28.7,0.00555556,OTO_ES_AF,WFS1
615515,4:6302680:C>T,NM_006005.3:c.1158C>T,NP_005996.2:p.Pro386=,8/8,\N,Benign,\N,synonymous_variant,6.55,0.0106673,EVS_AA_AF,WFS1
615516,4:6302681:A>G,NM_006005.3:c.1159A>G,NP_005996.2:p.Asn387Asp,8/8,\N,Likely benign,\N,missense_variant,1.102,0.000014984,EXAC_NFE_AF,WFS1
615517,4:6302687:G>C,NM_006005.3:c.1165G>C,NP_005996.2:p.Asp389His,8/8,\N,Unknown significance,\N,missense_variant,24.8,\N,\N,WFS1
615518,4:6302688:A>C,NM_006005.3:c.1166A>C,NP_005996.2:p.Asp389Ala,8/8,\N,Unknown significance,\N,missense_variant,24.8,0.0000863707,EXAC_AMR_AF,WFS1
615519,4:6302689:T>G,NM_006005.3:c.1167T>G,NP_005996.2:p.Asp389Glu,8/8,\N,Unknown significance,\N,missense_variant,23.3,0.0014,1KG_AMR_AF,WFS1
615520,4:6302693:G>A,NM_006005.3:c.1171G>A,NP_005996.2:p.Glu391Lys,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.000116279,EVS_EA_AF,WFS1
615521,4:6302694:A>G,NM_006005.3:c.1172A>G,NP_005996.2:p.Glu391Gly,8/8,\N,Unknown significance,\N,missense_variant,25.9,0.000115554,EXAC_EAS_AF,WFS1
615522,4:6302695:G>A,NM_006005.3:c.1173G>A,NP_005996.2:p.Glu391=,8/8,\N,Unknown significance,\N,synonymous_variant,1.696,0.0032355,EXAC_EAS_AF,WFS1
615523,4:6302696:C>T,NM_006005.3:c.1174C>T,NP_005996.2:p.Gln392Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,37,\N,\N,WFS1
615524,4:6302701:C>T,NM_006005.3:c.1179C>T,NP_005996.2:p.Ala393=,8/8,\N,Unknown significance,\N,synonymous_variant,12.46,0.0000449506,EXAC_NFE_AF,WFS1
615525,4:6302702:G>A,NM_006005.3:c.1180G>A,NP_005996.2:p.Glu394Lys,8/8,\N,Unknown significance,\N,missense_variant,29.4,0.000116279,EVS_EA_AF,WFS1
615526,4:6302703:A>T,NM_006005.3:c.1181A>T,NP_005996.2:p.Glu394Val,8/8,\N,Unknown significance,\N,missense_variant,26.1,0.000209769,EXAC_NFE_AF,WFS1
615527,4:6302704:G>T,NM_006005.3:c.1182G>T,NP_005996.2:p.Glu394Asp,8/8,\N,Unknown significance,\N,missense_variant,23.9,0.0000149835,EXAC_NFE_AF,WFS1
615528,4:6302706:T>A,NM_006005.3:c.1184T>A,NP_005996.2:p.Val395Asp,8/8,\N,Likely benign,\N,missense_variant,21.2,0.0000149835,EXAC_NFE_AF,WFS1
615529,4:6302707:C>T,NM_006005.3:c.1185C>T,NP_005996.2:p.Val395=,8/8,\N,Benign,\N,synonymous_variant,7.842,0.935752,EXAC_EAS_AF,WFS1
615530,4:6302707:C>G,NM_006005.3:c.1185C>G,NP_005996.2:p.Val395=,8/8,\N,Unknown significance,\N,synonymous_variant,3.097,\N,\N,WFS1
615531,4:6302709:A>G,NM_006005.3:c.1187A>G,NP_005996.2:p.Asn396Ser,8/8,\N,Unknown significance,\N,missense_variant,22.5,0.0000149835,EXAC_NFE_AF,WFS1
615532,4:6302710:C>T,NM_006005.3:c.1188C>T,NP_005996.2:p.Asn396=,8/8,\N,Unknown significance,\N,synonymous_variant,5.9,\N,\N,WFS1
615533,4:6302713:C>G,NM_006005.3:c.1191C>G,NP_005996.2:p.Phe397Leu,8/8,\N,Unknown significance,\N,missense_variant,24.8,\N,\N,WFS1
615534,4:6302713:C>T,NM_006005.3:c.1191C>T,NP_005996.2:p.Phe397=,8/8,\N,Unknown significance,\N,synonymous_variant,11.25,0.001,1KG_SAS_AF,WFS1
615535,4:6302714:G>C,NM_006005.3:c.1192G>C,NP_005996.2:p.Gly398Arg,8/8,\N,Unknown significance,\N,missense_variant,24,\N,\N,WFS1
615536,4:6302716:C>A,NM_006005.3:c.1194C>A,NP_005996.2:p.Gly398=,8/8,\N,Unknown significance,\N,synonymous_variant,8.635,0.000226963,EVS_AA_AF,WFS1
615537,4:6302716:C>T,NM_006005.3:c.1194C>T,NP_005996.2:p.Gly398=,8/8,\N,Unknown significance,\N,synonymous_variant,7.933,0.001,1KG_SAS_AF,WFS1
615538,4:6302717:T>G,NM_006005.3:c.1195T>G,NP_005996.2:p.Trp399Gly,8/8,\N,Likely pathogenic,\N,missense_variant,23.6,0.0000960984,EXAC_AFR_AF,WFS1
615539,4:6302719:G>A,NM_006005.3:c.1197G>A,NP_005996.2:p.Trp399Ter,8/8,\N,Unknown significance,\N,stop_gained,37,0.000151194,EXAC_FIN_AF,WFS1
615540,4:6302721:A>G,NM_006005.3:c.1199A>G,NP_005996.2:p.Asn400Ser,8/8,\N,Unknown significance,\N,missense_variant,23.6,0.0000149835,EXAC_NFE_AF,WFS1
615541,4:6302726:C>T,NM_006005.3:c.1204C>T,NP_005996.2:p.Leu402=,8/8,\N,Unknown significance,\N,synonymous_variant,5.533,0.0000149835,EXAC_NFE_AF,WFS1
615542,4:6302727:T>C,NM_006005.3:c.1205T>C,NP_005996.2:p.Leu402Pro,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.2,0.0000149835,EXAC_NFE_AF,WFS1
615543,4:6302727:T>G,NM_006005.3:c.1205T>G,NP_005996.2:p.Leu402Arg,8/8,\N,Unknown significance,\N,missense_variant,25.8,0.000060562,EXAC_SAS_AF,WFS1
615544,4:6302731:G>A,NM_006005.3:c.1209G>A,NP_005996.2:p.Glu403=,8/8,\N,Unknown significance,\N,synonymous_variant,2.029,0.0000149835,EXAC_NFE_AF,WFS1
615545,4:6302731:G>T,NM_006005.3:c.1209G>T,NP_005996.2:p.Glu403Asp,8/8,\N,Unknown significance,\N,missense_variant,25.4,0.00220751,EXAC_OTH_AF,WFS1
615546,4:6302732:C>G,NM_006005.3:c.1210C>G,NP_005996.2:p.Pro404Ala,8/8,\N,Unknown significance,\N,missense_variant,24.2,0.0000149835,EXAC_NFE_AF,WFS1
615547,4:6302734:C>G,NM_006005.3:c.1212C>G,NP_005996.2:p.Pro404=,8/8,\N,Unknown significance,\N,synonymous_variant,4.475,0.000060562,EXAC_SAS_AF,WFS1
615548,4:6302734:C>T,NM_006005.3:c.1212C>T,NP_005996.2:p.Pro404=,8/8,\N,Unknown significance,\N,synonymous_variant,6.559,0.001,1KG_EUR_AF,WFS1
615549,4:6302736:A>G,NM_006005.3:c.1214A>G,NP_005996.2:p.Tyr405Cys,8/8,\N,Unknown significance,\N,missense_variant,22.6,0.0000149835,EXAC_NFE_AF,WFS1
615550,4:6302741:C>T,NM_006005.3:c.1219C>T,NP_005996.2:p.His407Tyr,8/8,\N,Unknown significance,\N,missense_variant,1.221,0.000453926,EVS_AA_AF,WFS1
615551,4:6302741:C>G,NM_006005.3:c.1219C>G,NP_005996.2:p.His407Asp,8/8,\N,Unknown significance,\N,missense_variant,22.8,0.0008,1KG_AFR_AF,WFS1
615552,4:6302742:A>G,NM_006005.3:c.1220A>G,NP_005996.2:p.His407Arg,8/8,\N,Unknown significance,\N,missense_variant,20.1,0.0015,1KG_AFR_AF,WFS1
615553,4:6302743:T>G,NM_006005.3:c.1221T>G,NP_005996.2:p.His407Gln,8/8,\N,Unknown significance,\N,missense_variant,18.84,0.0000149835,EXAC_NFE_AF,WFS1
615554,4:6302746:C>T,NM_006005.3:c.1224C>T,NP_005996.2:p.Phe408=,8/8,\N,Unknown significance,\N,synonymous_variant,6.249,0.000115554,EXAC_EAS_AF,WFS1
615555,4:6302747:C>T,NM_006005.3:c.1225C>T,NP_005996.2:p.Leu409=,8/8,\N,Unknown significance,\N,synonymous_variant,3.964,0.000115554,EXAC_EAS_AF,WFS1
615556,4:6302749:G>A,NM_006005.3:c.1227G>A,NP_005996.2:p.Leu409=,8/8,\N,Unknown significance,\N,synonymous_variant,0.018,0.000014984,EXAC_NFE_AF,WFS1
615557,4:6302749:GCTCT>G,NM_006005.3:c.1230_1233del,NP_005996.2:p.Val412SerfsTer29,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,27.5,0.000172741,EXAC_AMR_AF,WFS1
615558,4:6302749:GC>G,NM_006005.3:c.1228del,NP_005996.2:p.Leu410SerfsTer32,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,25.7,\N,\N,WFS1
615559,4:6302749:GCT>G,NM_006005.3:c.1232_1233del,NP_005996.2:p.Ser411CysfsTer131,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,27.4,\N,\N,WFS1
615560,4:6302750:C>T,NM_006005.3:c.1228C>T,NP_005996.2:p.Leu410Phe,8/8,\N,Unknown significance,\N,missense_variant,10.57,0.001,1KG_EAS_AF,WFS1
615561,4:6302752:CTCTG>C,NM_006005.3:c.1234_1237del,NP_005996.2:p.Val412SerfsTer29,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,26.8,0.0000149844,EXAC_NFE_AF,WFS1
615562,4:6302752:C>G,NM_006005.3:c.1230C>G,NP_005996.2:p.Leu410=,8/8,\N,Unknown significance,\N,synonymous_variant,0.034,0.0000149844,EXAC_NFE_AF,WFS1
615563,4:6302752:C>T,NM_006005.3:c.1230C>T,NP_005996.2:p.Leu410=,8/8,\N,Unknown significance,\N,synonymous_variant,0.152,0.000259112,EXAC_AMR_AF,WFS1
615564,4:6302755:T>G,NM_006005.3:c.1233T>G,NP_005996.2:p.Ser411=,8/8,\N,Unknown significance,\N,synonymous_variant,0.002,0.000666182,EXAC_SAS_AF,WFS1
615565,4:6302756:G>C,NM_006005.3:c.1234G>C,NP_005996.2:p.Val412Leu,8/8,\N,Benign,\N,missense_variant,11.24,0.0175,OTO_JP_AF,WFS1
615566,4:6302756:GTCT>G,NM_006005.3:c.1240_1242del,NP_005996.2:p.Phe414del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,3.368,\N,\N,WFS1
615567,4:6302756:G>A,NM_006005.3:c.1234G>A,NP_005996.2:p.Val412Ile,8/8,\N,Unknown significance,\N,missense_variant,18.12,0.0000299679,EXAC_NFE_AF,WFS1
615568,4:6302757:T>C,NM_006005.3:c.1235T>C,NP_005996.2:p.Val412Ala,8/8,\N,Benign*,\N,missense_variant,21.1,0.015,OTO_JP_AF,WFS1
615569,4:6302757:T>A,NM_006005.3:c.1235T>A,NP_005996.2:p.Val412Asp,8/8,\N,Unknown significance,\N,missense_variant,23.4,0.000181686,EXAC_SAS_AF,WFS1
615570,4:6302758:C>T,NM_006005.3:c.1236C>T,NP_005996.2:p.Val412=,8/8,\N,Unknown significance,\N,synonymous_variant,0.048,0.000181686,EXAC_SAS_AF,WFS1
615571,4:6302759:T>G,NM_006005.3:c.1237T>G,NP_005996.2:p.Phe413Val,8/8,\N,Likely benign,\N,missense_variant,0.001,0.0008,1KG_AFR_AF,WFS1
615572,4:6302762:TTCG>T,NM_006005.3:c.1243_1245del,NP_005996.2:p.Val415del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,6.756,0.0000960984,EXAC_AFR_AF,WFS1
615573,4:6302762:T>C,NM_006005.3:c.1240T>C,NP_005996.2:p.Phe414Leu,8/8,\N,Unknown significance,\N,missense_variant,14.65,0.000115554,EXAC_EAS_AF,WFS1
615574,4:6302764:C>T,NM_006005.3:c.1242C>T,NP_005996.2:p.Phe414=,8/8,\N,Unknown significance,\N,synonymous_variant,0.573,0.000346661,EXAC_EAS_AF,WFS1
615575,4:6302765:G>A,NM_006005.3:c.1243G>A,NP_005996.2:p.Val415Ile,8/8,\N,Unknown significance,\N,missense_variant,16.33,0.000346661,EXAC_EAS_AF,WFS1
615576,4:6302765:G>C,NM_006005.3:c.1243G>C,NP_005996.2:p.Val415Leu,8/8,\N,Unknown significance,\N,missense_variant,16.84,0.0000863707,EXAC_AMR_AF,WFS1
615577,4:6302768:ATCT>A,NM_006005.3:c.1250_1252del,NP_005996.2:p.Phe417del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,8.024,\N,\N,WFS1
615578,4:6302772:T>C,NM_006005.3:c.1250T>C,NP_005996.2:p.Phe417Ser,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.0000149835,EXAC_NFE_AF,WFS1
615579,4:6302773:C>T,NM_006005.3:c.1251C>T,NP_005996.2:p.Phe417=,8/8,\N,Unknown significance,\N,synonymous_variant,0.51,0.000423934,EXAC_SAS_AF,WFS1
615580,4:6302773:CT>G,NM_006005.3:c.1251_1252delinsG,NP_005996.2:p.Phe417LeufsTer25,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,\N,\N,\N,WFS1
615581,4:6302775:C>A,NM_006005.3:c.1253C>A,NP_005996.2:p.Ser418Tyr,8/8,\N,Unknown significance,\N,missense_variant,23.9,0.0000149835,EXAC_NFE_AF,WFS1
615582,4:6302775:C>CTCT,NM_006005.3:c.1253_1254insTCT,NP_005996.2:p.Ser418_Phe419insLeu,8/8,\N,Pathogenic,Wolfram syndrome,inframe_insertion,8.266,\N,\N,WFS1
615583,4:6302778:T>TC,NM_006005.3:c.1260dup,NP_005996.2:p.Ile421HisfsTer122,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,25.6,\N,\N,WFS1
615584,4:6302783:A>G,NM_006005.3:c.1261A>G,NP_005996.2:p.Ile421Val,8/8,\N,Likely benign,\N,missense_variant,0.001,\N,\N,WFS1
615585,4:6302783:A>C,NM_006005.3:c.1261A>C,NP_005996.2:p.Ile421Leu,8/8,\N,Likely benign,\N,missense_variant,0.001,0.0000149835,EXAC_NFE_AF,WFS1
615586,4:6302785:C>G,NM_006005.3:c.1263C>G,NP_005996.2:p.Ile421Met,8/8,\N,Likely benign,\N,missense_variant,0.402,0.000115554,EXAC_EAS_AF,WFS1
615587,4:6302785:C>T,NM_006005.3:c.1263C>T,NP_005996.2:p.Ile421=,8/8,\N,Unknown significance,\N,synonymous_variant,1.244,0.000060562,EXAC_SAS_AF,WFS1
615588,4:6302786:G>A,NM_006005.3:c.1264G>A,NP_005996.2:p.Ala422Thr,8/8,\N,Unknown significance,\N,missense_variant,4.713,0.000121124,EXAC_SAS_AF,WFS1
615589,4:6302786:G>T,NM_006005.3:c.1264G>T,NP_005996.2:p.Ala422Ser,8/8,\N,Unknown significance,\N,missense_variant,14.4,0.000346661,EXAC_EAS_AF,WFS1
615590,4:6302787:C>T,NM_006005.3:c.1265C>T,NP_005996.2:p.Ala422Val,8/8,\N,Unknown significance,\N,missense_variant,0.582,0.000465116,EVS_EA_AF,WFS1
615591,4:6302790:G>A,NM_006005.3:c.1268G>A,NP_005996.2:p.Ser423Asn,8/8,\N,Unknown significance,\N,missense_variant,3.111,0.0008,1KG_AFR_AF,WFS1
615592,4:6302791:C>G,NM_006005.3:c.1269C>G,NP_005996.2:p.Ser423Arg,8/8,\N,Unknown significance,\N,missense_variant,11.09,0.000116279,EVS_EA_AF,WFS1
615593,4:6302792:A>C,NM_006005.3:c.1270A>C,NP_005996.2:p.Lys424Gln,8/8,\N,Unknown significance,\N,missense_variant,9.629,0.001,1KG_EUR_AF,WFS1
615594,4:6302795:G>A,NM_006005.3:c.1273G>A,NP_005996.2:p.Asp425Asn,8/8,\N,Likely benign,\N,missense_variant,7.376,0.000116279,EVS_EA_AF,WFS1
615595,4:6302796:A>C,NM_006005.3:c.1274A>C,NP_005996.2:p.Asp425Ala,8/8,\N,Unknown significance,\N,missense_variant,11.86,0.000121124,EXAC_SAS_AF,WFS1
615596,4:6302799:G>A,NM_006005.3:c.1277G>A,NP_005996.2:p.Cys426Tyr,8/8,\N,Benign,\N,missense_variant,14.96,0.05,OTO_AJ_AF,WFS1
615597,4:6302799:G>C,NM_006005.3:c.1277G>C,NP_005996.2:p.Cys426Ser,8/8,\N,Unknown significance,\N,missense_variant,13.29,0.000115554,EXAC_EAS_AF,WFS1
615598,4:6302802:T>A,NM_006005.3:c.1280T>A,NP_005996.2:p.Ile427Asn,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.1,\N,\N,WFS1
615599,4:6302802:T>G,NM_006005.3:c.1280T>G,NP_005996.2:p.Ile427Ser,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.6,\N,\N,WFS1
615600,4:6302803:C>G,NM_006005.3:c.1281C>G,NP_005996.2:p.Ile427Met,8/8,\N,Likely benign,\N,missense_variant,3.941,0.000115554,EXAC_EAS_AF,WFS1
615601,4:6302805:C>T,NM_006005.3:c.1283C>T,NP_005996.2:p.Pro428Leu,8/8,\N,Unknown significance,\N,missense_variant,26.4,0.000115554,EXAC_EAS_AF,WFS1
615602,4:6302807:T>C,NM_006005.3:c.1285T>C,NP_005996.2:p.Cys429Arg,8/8,\N,Unknown significance,\N,missense_variant,14.36,0.000115554,EXAC_EAS_AF,WFS1
615603,4:6302809:C>T,NM_006005.3:c.1287C>T,NP_005996.2:p.Cys429=,8/8,\N,Unknown significance,\N,synonymous_variant,4.48,\N,\N,WFS1
615604,4:6302811:C>G,NM_006005.3:c.1289C>G,NP_005996.2:p.Ser430Trp,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,27.6,\N,\N,WFS1
615605,4:6302811:C>T,NM_006005.3:c.1289C>T,NP_005996.2:p.Ser430Leu,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,28.7,\N,\N,WFS1
615606,4:6302812:G>A,NM_006005.3:c.1290G>A,NP_005996.2:p.Ser430=,8/8,\N,Unknown significance,\N,synonymous_variant,7.628,0.0000299715,EXAC_NFE_AF,WFS1
615607,4:6302814:A>G,NM_006005.3:c.1292A>G,NP_005996.2:p.Glu431Gly,8/8,\N,Unknown significance,\N,missense_variant,26,0.0000149858,EXAC_NFE_AF,WFS1
615608,4:6302816:C>G,NM_006005.3:c.1294C>G,NP_005996.2:p.Leu432Val,8/8,\N,Benign,\N,missense_variant,23.7,0.04,OTO_AJ_AF,WFS1
615609,4:6302816:C>T,NM_006005.3:c.1294C>T,NP_005996.2:p.Leu432=,8/8,\N,Likely benign,\N,synonymous_variant,2.687,0.000254758,EXAC_NFE_AF,WFS1
615610,4:6302817:T>A,NM_006005.3:c.1295T>A,NP_005996.2:p.Leu432Gln,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.2,\N,\N,WFS1
615611,4:6302817:T>G,NM_006005.3:c.1295T>G,NP_005996.2:p.Leu432Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.3,\N,\N,WFS1
615612,4:6302818:G>A,NM_006005.3:c.1296G>A,NP_005996.2:p.Leu432=,8/8,\N,Unknown significance,\N,synonymous_variant,0.724,0.000116279,EVS_EA_AF,WFS1
615613,4:6302819:G>A,NM_006005.3:c.1297G>A,NP_005996.2:p.Ala433Thr,8/8,\N,Unknown significance,\N,missense_variant,20.7,0.000232558,EVS_EA_AF,WFS1
615614,4:6302821:TGTC>T,NM_006005.3:c.1300_1302del,NP_005996.2:p.Val434del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,4.988,\N,\N,WFS1
615615,4:6302822:G>C,NM_006005.3:c.1300G>C,NP_005996.2:p.Val434Leu,8/8,\N,Likely benign,\N,missense_variant,0.192,0.0000863707,EXAC_AMR_AF,WFS1
615616,4:6302824:C>T,NM_006005.3:c.1302C>T,NP_005996.2:p.Val434=,8/8,\N,Unknown significance,\N,synonymous_variant,1.955,0.00068089,EVS_AA_AF,WFS1
615617,4:6302827:C>T,NM_006005.3:c.1305C>T,NP_005996.2:p.Ile435=,8/8,\N,Unknown significance,\N,synonymous_variant,0.492,0.0008,1KG_AFR_AF,WFS1
615618,4:6302828:A>G,NM_006005.3:c.1306A>G,NP_005996.2:p.Thr436Ala,8/8,\N,Likely benign,\N,missense_variant,0.001,0.0014,1KG_AMR_AF,WFS1
615619,4:6302828:AC>A,NM_006005.3:c.1308del,NP_005996.2:p.Gly437AlafsTer5,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,\N,\N,\N,WFS1
615620,4:6302829:C>G,NM_006005.3:c.1307C>G,NP_005996.2:p.Thr436Ser,8/8,\N,Likely benign,\N,missense_variant,0.052,0.000060562,EXAC_SAS_AF,WFS1
615621,4:6302830:C>T,NM_006005.3:c.1308C>T,NP_005996.2:p.Thr436=,8/8,\N,Benign,\N,synonymous_variant,6.026,0.015625,OTO_US_AF,WFS1
615622,4:6302830:C>A,NM_006005.3:c.1308C>A,NP_005996.2:p.Thr436=,8/8,\N,Unknown significance,\N,synonymous_variant,10.89,0.000060562,EXAC_SAS_AF,WFS1
615623,4:6302831:G>A,NM_006005.3:c.1309G>A,NP_005996.2:p.Gly437Ser,8/8,\N,Benign,\N,missense_variant,8.649,0.00797319,EXAC_EAS_AF,WFS1
615624,4:6302831:G>C,NM_006005.3:c.1309G>C,NP_005996.2:p.Gly437Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,7.166,0.0000149907,EXAC_NFE_AF,WFS1
615625,4:6302831:G>T,NM_006005.3:c.1309G>T,NP_005996.2:p.Gly437Cys,8/8,\N,Likely benign,\N,missense_variant,8.702,0.000226963,EVS_AA_AF,WFS1
615626,4:6302836:C>G,NM_006005.3:c.1314C>G,NP_005996.2:p.Phe438Leu,8/8,\N,Unknown significance,\N,missense_variant,22.4,\N,\N,WFS1
615627,4:6302837:T>C,NM_006005.3:c.1315T>C,NP_005996.2:p.Phe439Leu,8/8,\N,Unknown significance,\N,missense_variant,16.75,0.0000149903,EXAC_NFE_AF,WFS1
615628,4:6302838:T>G,NM_006005.3:c.1316T>G,NP_005996.2:p.Phe439Cys,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23.8,0.000232558,EVS_EA_AF,WFS1
615629,4:6302841:C>T,NM_006005.3:c.1319C>T,NP_005996.2:p.Thr440Ile,8/8,\N,Unknown significance,\N,missense_variant,24.2,0.0000962279,EXAC_AFR_AF,WFS1
615630,4:6302842:C>T,NM_006005.3:c.1320C>T,NP_005996.2:p.Thr440=,8/8,\N,Unknown significance,\N,synonymous_variant,3.69,0.000604778,EXAC_FIN_AF,WFS1
615631,4:6302843:G>A,NM_006005.3:c.1321G>A,NP_005996.2:p.Val441Met,8/8,\N,Benign,\N,missense_variant,10.98,0.0053,1KG_AFR_AF,WFS1
615632,4:6302845:G>A,NM_006005.3:c.1323G>A,NP_005996.2:p.Val441=,8/8,\N,Unknown significance,\N,synonymous_variant,0.647,0.000226963,EVS_AA_AF,WFS1
615633,4:6302847:C>G,NM_006005.3:c.1325C>G,NP_005996.2:p.Thr442Ser,8/8,\N,Unknown significance,\N,missense_variant,12.28,\N,\N,WFS1
615634,4:6302848:C>T,NM_006005.3:c.1326C>T,NP_005996.2:p.Thr442=,8/8,\N,Unknown significance,\N,synonymous_variant,4.896,\N,\N,WFS1
615635,4:6302850:G>T,NM_006005.3:c.1328G>T,NP_005996.2:p.Ser443Ile,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.1,\N,\N,WFS1
615636,4:6302851:C>T,NM_006005.3:c.1329C>T,NP_005996.2:p.Ser443=,8/8,\N,Unknown significance,\N,synonymous_variant,4.57,0.000116279,EVS_EA_AF,WFS1
615637,4:6302851:C>G,NM_006005.3:c.1329C>G,NP_005996.2:p.Ser443Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23.6,\N,\N,WFS1
615638,4:6302853:ACCTGAG>A,NM_006005.3:c.1339_1344del,NP_005996.2:p.Leu447_Ser448del,8/8,\N,Unknown significance,\N,inframe_deletion,14.19,\N,\N,WFS1
615639,4:6302854:C>G,NM_006005.3:c.1332C>G,NP_005996.2:p.Tyr444Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,37,\N,\N,WFS1
615640,4:6302855:C>G,NM_006005.3:c.1333C>G,NP_005996.2:p.Leu445Val,8/8,\N,Likely benign,\N,missense_variant,4.765,0.0000864006,EXAC_AMR_AF,WFS1
615641,4:6302855:C>T,NM_006005.3:c.1333C>T,NP_005996.2:p.Leu445=,8/8,\N,Unknown significance,\N,synonymous_variant,5.095,0.000115607,EXAC_EAS_AF,WFS1
615642,4:6302864:A>G,NM_006005.3:c.1342A>G,NP_005996.2:p.Ser448Gly,8/8,\N,Unknown significance,\N,missense_variant,3.003,0.0000864006,EXAC_AMR_AF,WFS1
615643,4:6302868:C>G,NM_006005.3:c.1346C>G,NP_005996.2:p.Thr449Ser,8/8,\N,Likely benign,\N,missense_variant,2.633,0.00110375,EXAC_OTH_AF,WFS1
615644,4:6302868:C>T,NM_006005.3:c.1346C>T,NP_005996.2:p.Thr449Ile,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,9.951,0.0000605694,EXAC_SAS_AF,WFS1
615645,4:6302872:T>TGCAGAGCCCTACACGC,NM_006005.3:c.1355_1370dup,NP_005996.2:p.Ala460HisfsTer88,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,29.8,\N,\N,WFS1
615646,4:6302872:TGCAGAGCCCTACACGC>T,NM_006005.3:c.1355_1370del,NP_005996.2:p.Glu452GlyfsTer20,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
615647,4:6302875:A>G,NM_006005.3:c.1353A>G,NP_005996.2:p.Ala451=,8/8,\N,Unknown significance,\N,synonymous_variant,0.024,0.0025,OTO_JP_AF,WFS1
615648,4:6302878:GC>G,NM_006005.3:c.1359del,NP_005996.2:p.Tyr454ThrfsTer23,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,32,\N,\N,WFS1
615649,4:6302881:C>T,NM_006005.3:c.1359C>T,NP_005996.2:p.Pro453=,8/8,\N,Unknown significance,\N,synonymous_variant,7.309,0.0000300021,EXAC_NFE_AF,WFS1
615650,4:6302883:ACACGCGCAGGGCCCTG>A,NM_006005.3:c.1362_1377del,NP_005996.2:p.Tyr454Ter,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
615651,4:6302886:C>T,NM_006005.3:c.1364C>T,NP_005996.2:p.Thr455Met,8/8,\N,Likely pathogenic,Cerebellar ataxia,missense_variant,25,0.000453926,EVS_AA_AF,WFS1
615652,4:6302887:G>A,NM_006005.3:c.1365G>A,NP_005996.2:p.Thr455=,8/8,\N,Unknown significance,\N,synonymous_variant,6.745,0.000605767,EXAC_SAS_AF,WFS1
615653,4:6302887:G>C,NM_006005.3:c.1365G>C,NP_005996.2:p.Thr455=,8/8,\N,Unknown significance,\N,synonymous_variant,1.375,0.0000864155,EXAC_AMR_AF,WFS1
615654,4:6302887:GCGCAGGGCCCTGGCCA>G,NM_006005.3:c.1367_1382del,NP_005996.2:p.Arg456ProfsTer16,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
615655,4:6302888:C>T,NM_006005.3:c.1366C>T,NP_005996.2:p.Arg456Cys,8/8,\N,Likely pathogenic,Cerebellar ataxia,missense_variant,24.1,0.000385579,EXAC_AFR_AF,WFS1
615656,4:6302889:G>A,NM_006005.3:c.1367G>A,NP_005996.2:p.Arg456His,8/8,\N,Benign,\N,missense_variant,23.8,0.12,OTO_TR_AF,WFS1
615657,4:6302889:G>C,NM_006005.3:c.1367G>C,NP_005996.2:p.Arg456Pro,8/8,\N,Unknown significance,\N,missense_variant,24,\N,\N,WFS1
615658,4:6302889:G>T,NM_006005.3:c.1367G>T,NP_005996.2:p.Arg456Leu,8/8,\N,Unknown significance,\N,missense_variant,23.2,\N,\N,WFS1
615659,4:6302893:G>T,NM_006005.3:c.1371G>T,NP_005996.2:p.Arg457Ser,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,20.6,0.000585217,EXAC_NFE_AF,WFS1
615660,4:6302897:C>T,NM_006005.3:c.1375C>T,NP_005996.2:p.Leu459=,8/8,\N,Unknown significance,\N,synonymous_variant,7.837,\N,\N,WFS1
615661,4:6302899:G>A,NM_006005.3:c.1377G>A,NP_005996.2:p.Leu459=,8/8,\N,Unknown significance,\N,synonymous_variant,1.171,0.00113482,EVS_AA_AF,WFS1
615662,4:6302900:G>A,NM_006005.3:c.1378G>A,NP_005996.2:p.Ala460Thr,8/8,\N,Unknown significance,\N,missense_variant,12.98,0.0000150078,EXAC_NFE_AF,WFS1
615663,4:6302901:C>T,NM_006005.3:c.1379C>T,NP_005996.2:p.Ala460Val,8/8,\N,Likely benign,\N,missense_variant,7.884,0.000226963,EVS_AA_AF,WFS1
615664,4:6302901:CCACCGAGGT>C,NM_006005.3:c.1385_1393del,NP_005996.2:p.Glu462_Thr464del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,12.47,\N,\N,WFS1
615665,4:6302903:A>G,NM_006005.3:c.1381A>G,NP_005996.2:p.Thr461Ala,8/8,\N,Unknown significance,\N,missense_variant,8.947,0.000193013,EXAC_AFR_AF,WFS1
615666,4:6302903:A>C,NM_006005.3:c.1381A>C,NP_005996.2:p.Thr461Pro,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,21.9,\N,\N,WFS1
615667,4:6302904:C>G,NM_006005.3:c.1382C>G,NP_005996.2:p.Thr461Ser,8/8,\N,Likely pathogenic,Wolfram syndrome,missense_variant,12.99,\N,\N,WFS1
615668,4:6302905:C>T,NM_006005.3:c.1383C>T,NP_005996.2:p.Thr461=,8/8,\N,Unknown significance,\N,synonymous_variant,11.06,0.0000605987,EXAC_SAS_AF,WFS1
615669,4:6302907:A>G,NM_006005.3:c.1385A>G,NP_005996.2:p.Glu462Gly,8/8,\N,Pathogenic,Cataract| nuclear,missense_variant,23.3,\N,\N,WFS1
615670,4:6302907:A>AGGTCACCGC,NM_006005.3:c.1386_1394dup,NP_005996.2:p.Val463_Ala465dup,8/8,\N,Unknown significance,\N,inframe_insertion,5.304,\N,\N,WFS1
615671,4:6302908:G>A,NM_006005.3:c.1386G>A,NP_005996.2:p.Glu462=,8/8,\N,Unknown significance,\N,synonymous_variant,0.139,0.0025,OTO_JP_AF,WFS1
615672,4:6302913:C>G,NM_006005.3:c.1391C>G,NP_005996.2:p.Thr464Ser,8/8,\N,Likely benign,\N,missense_variant,0.05,0.000116279,EVS_EA_AF,WFS1
615673,4:6302914:C>T,NM_006005.3:c.1392C>T,NP_005996.2:p.Thr464=,8/8,\N,Likely benign,\N,synonymous_variant,1.797,0.000518672,EXAC_AMR_AF,WFS1
615674,4:6302915:G>A,NM_006005.3:c.1393G>A,NP_005996.2:p.Ala465Thr,8/8,\N,Unknown significance,\N,missense_variant,10.64,0.000105111,EXAC_NFE_AF,WFS1
615675,4:6302917:C>T,NM_006005.3:c.1395C>T,NP_005996.2:p.Ala465=,8/8,\N,Benign,\N,synonymous_variant,6.14,0.0072,1KG_SAS_AF,WFS1
615676,4:6302918:G>A,NM_006005.3:c.1396G>A,NP_005996.2:p.Gly466Ser,8/8,\N,Unknown significance,\N,missense_variant,11.18,\N,\N,WFS1
615677,4:6302920:C>A,NM_006005.3:c.1398C>A,NP_005996.2:p.Gly466=,8/8,\N,Unknown significance,\N,synonymous_variant,4.056,0.0008,1KG_AFR_AF,WFS1
615678,4:6302920:C>T,NM_006005.3:c.1398C>T,NP_005996.2:p.Gly466=,8/8,\N,Unknown significance,\N,synonymous_variant,1.653,0.000060584,EXAC_SAS_AF,WFS1
615679,4:6302920:CCTG>C,NM_006005.3:c.1401_1403del,NP_005996.2:p.Leu468del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,2.512,\N,\N,WFS1
615680,4:6302921:C>T,NM_006005.3:c.1399C>T,NP_005996.2:p.Leu467=,8/8,\N,Unknown significance,\N,synonymous_variant,1.174,0.001,1KG_EUR_AF,WFS1
615681,4:6302924:C>T,NM_006005.3:c.1402C>T,NP_005996.2:p.Leu468=,8/8,\N,Unknown significance,\N,synonymous_variant,0.139,\N,\N,WFS1
615682,4:6302926:A>G,NM_006005.3:c.1404A>G,NP_005996.2:p.Leu468=,8/8,\N,Unknown significance,\N,synonymous_variant,0.005,0.0000150128,EXAC_NFE_AF,WFS1
615683,4:6302928:C>T,NM_006005.3:c.1406C>T,NP_005996.2:p.Ser469Leu,8/8,\N,Unknown significance,\N,missense_variant,23.3,0.002,1KG_SAS_AF,WFS1
615684,4:6302929:G>T,NM_006005.3:c.1407G>T,NP_005996.2:p.Ser469=,8/8,\N,Unknown significance,\N,synonymous_variant,0.012,\N,\N,WFS1
615685,4:6302930:C>G,NM_006005.3:c.1408C>G,NP_005996.2:p.Leu470Val,8/8,\N,Unknown significance,\N,missense_variant,2.475,0.000115634,EXAC_EAS_AF,WFS1
615686,4:6302930:C>T,NM_006005.3:c.1408C>T,NP_005996.2:p.Leu470=,8/8,\N,Unknown significance,\N,synonymous_variant,0.439,0.0000300255,EXAC_NFE_AF,WFS1
615687,4:6302932:G>C,NM_006005.3:c.1410G>C,NP_005996.2:p.Leu470=,8/8,\N,Unknown significance,\N,synonymous_variant,0.004,0.0000300228,EXAC_NFE_AF,WFS1
615688,4:6302933:C>T,NM_006005.3:c.1411C>T,NP_005996.2:p.Leu471=,8/8,\N,Unknown significance,\N,synonymous_variant,0.768,0.0000864454,EXAC_AMR_AF,WFS1
615689,4:6302938:C>A,NM_006005.3:c.1416C>A,NP_005996.2:p.Pro472=,8/8,\N,Unknown significance,\N,synonymous_variant,2.823,0.00110619,EXAC_OTH_AF,WFS1
615690,4:6302940:C>A,NM_006005.3:c.1418C>A,NP_005996.2:p.Ser473Tyr,8/8,\N,Likely benign,\N,missense_variant,0.001,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
615691,4:6302941:C>T,NM_006005.3:c.1419C>T,NP_005996.2:p.Ser473=,8/8,\N,Unknown significance,\N,synonymous_variant,0.132,0.0014,1KG_AMR_AF,WFS1
615692,4:6302942:A>C,NM_006005.3:c.1420A>C,NP_005996.2:p.Met474Leu,8/8,\N,Likely benign,\N,missense_variant,0.001,0.0000965065,EXAC_AFR_AF,WFS1
615693,4:6302942:A>G,NM_006005.3:c.1420A>G,NP_005996.2:p.Met474Val,8/8,\N,Likely benign,\N,missense_variant,0.001,0.0000150123,EXAC_NFE_AF,WFS1
615694,4:6302946:C>T,NM_006005.3:c.1424C>T,NP_005996.2:p.Pro475Leu,8/8,\N,Unknown significance,\N,missense_variant,23.2,0.0000150101,EXAC_NFE_AF,WFS1
615695,4:6302947:C>T,NM_006005.3:c.1425C>T,NP_005996.2:p.Pro475=,8/8,\N,Unknown significance,\N,synonymous_variant,0.325,0.000116279,EVS_EA_AF,WFS1
615696,4:6302953:T>C,NM_006005.3:c.1431T>C,NP_005996.2:p.Asn477=,8/8,\N,Unknown significance,\N,synonymous_variant,0.001,0.0000150119,EXAC_NFE_AF,WFS1
615697,4:6302955:G>A,NM_006005.3:c.1433G>A,NP_005996.2:p.Trp478Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,35,0.000232558,EVS_EA_AF,WFS1
615698,4:6302959:C>G,NM_006005.3:c.1437C>G,NP_005996.2:p.Pro479=,8/8,\N,Unknown significance,\N,synonymous_variant,0.08,0.000226963,EVS_AA_AF,WFS1
615699,4:6302959:C>T,NM_006005.3:c.1437C>T,NP_005996.2:p.Pro479=,8/8,\N,Unknown significance,\N,synonymous_variant,0.265,0.001,1KG_EAS_AF,WFS1
615700,4:6302960:T>C,NM_006005.3:c.1438T>C,NP_005996.2:p.Tyr480His,8/8,\N,Likely benign,\N,missense_variant,0.002,0.000115634,EXAC_EAS_AF,WFS1
615701,4:6302961:A>G,NM_006005.3:c.1439A>G,NP_005996.2:p.Tyr480Cys,8/8,\N,Likely benign,\N,missense_variant,0.005,0.0000605694,EXAC_SAS_AF,WFS1
615702,4:6302962:C>CCTGAAGG,NM_006005.3:c.1441_1447dup,NP_005996.2:p.Val483AlafsTer62,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,24.3,\N,\N,WFS1
615703,4:6302962:C>T,NM_006005.3:c.1440C>T,NP_005996.2:p.Tyr480=,8/8,\N,Unknown significance,\N,synonymous_variant,0.012,0.0000605694,EXAC_SAS_AF,WFS1
615704,4:6302963:C>T,NM_006005.3:c.1441C>T,NP_005996.2:p.Leu481=,8/8,\N,Likely benign,\N,synonymous_variant,0.123,\N,\N,WFS1
615705,4:6302964:T>C,NM_006005.3:c.1442T>C,NP_005996.2:p.Leu481Pro,8/8,\N,Unknown significance,\N,missense_variant,23.1,0.000259291,EXAC_AMR_AF,WFS1
615706,4:6302965:G>A,NM_006005.3:c.1443G>A,NP_005996.2:p.Leu481=,8/8,\N,Unknown significance,\N,synonymous_variant,0.052,\N,\N,WFS1
615707,4:6302967:A>G,NM_006005.3:c.1445A>G,NP_005996.2:p.Lys482Arg,8/8,\N,Unknown significance,\N,missense_variant,0.005,\N,\N,WFS1
615708,4:6302968:G>A,NM_006005.3:c.1446G>A,NP_005996.2:p.Lys482=,8/8,\N,Unknown significance,\N,synonymous_variant,0.079,0.0000964506,EXAC_AFR_AF,WFS1
615709,4:6302968:G>T,NM_006005.3:c.1446G>T,NP_005996.2:p.Lys482Asn,8/8,\N,Likely benign,\N,missense_variant,0.008,0.000226963,EVS_AA_AF,WFS1
615710,4:6302973:T>C,NM_006005.3:c.1451T>C,NP_005996.2:p.Leu484Pro,8/8,\N,Unknown significance,\N,missense_variant,15.34,0.0000964506,EXAC_AFR_AF,WFS1
615711,4:6302974:T>G,NM_006005.3:c.1452T>G,NP_005996.2:p.Leu484=,8/8,\N,Unknown significance,\N,synonymous_variant,0.002,0.000482346,EXAC_AFR_AF,WFS1
615712,4:6302978:C>T,NM_006005.3:c.1456C>T,NP_005996.2:p.Gln486Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,36,\N,\N,WFS1
615713,4:6302980:G>A,NM_006005.3:c.1458G>A,NP_005996.2:p.Gln486=,8/8,\N,Unknown significance,\N,synonymous_variant,0.088,0.0014,1KG_AMR_AF,WFS1
615714,4:6302980:G>C,NM_006005.3:c.1458G>C,NP_005996.2:p.Gln486His,8/8,\N,Unknown significance,\N,missense_variant,18.54,0.0000300219,EXAC_NFE_AF,WFS1
615715,4:6302982:C>G,NM_006005.3:c.1460C>G,NP_005996.2:p.Thr487Ser,8/8,\N,Unknown significance,\N,missense_variant,16.94,0.000192976,EXAC_AFR_AF,WFS1
615716,4:6302982:C>T,NM_006005.3:c.1460C>T,NP_005996.2:p.Thr487Ile,8/8,\N,Unknown significance,\N,missense_variant,22.6,0.00015124,EXAC_FIN_AF,WFS1
615717,4:6302983:C>T,NM_006005.3:c.1461C>T,NP_005996.2:p.Thr487=,8/8,\N,Unknown significance,\N,synonymous_variant,4.034,0.0000864155,EXAC_AMR_AF,WFS1
615718,4:6302987:A>G,NM_006005.3:c.1465A>G,NP_005996.2:p.Ile489Val,8/8,\N,Likely benign,\N,missense_variant,0.001,0.0000605694,EXAC_SAS_AF,WFS1
615719,4:6302988:T>A,NM_006005.3:c.1466T>A,NP_005996.2:p.Ile489Asn,8/8,\N,Likely benign,\N,missense_variant,8.407,0.000015011,EXAC_NFE_AF,WFS1
615720,4:6302989:C>G,NM_006005.3:c.1467C>G,NP_005996.2:p.Ile489Met,8/8,\N,Likely benign,\N,missense_variant,0.956,0.000030021,EXAC_NFE_AF,WFS1
615721,4:6302990:A>C,NM_006005.3:c.1468A>C,NP_005996.2:p.Thr490Pro,8/8,\N,Unknown significance,\N,missense_variant,20.1,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
615722,4:6302992:C>T,NM_006005.3:c.1470C>T,NP_005996.2:p.Thr490=,8/8,\N,Likely benign,\N,synonymous_variant,4.029,0.0029,1KG_AMR_AF,WFS1
615723,4:6302993:G>A,NM_006005.3:c.1471G>A,NP_005996.2:p.Val491Met,8/8,\N,Unknown significance,\N,missense_variant,2.864,0.001,1KG_EUR_AF,WFS1
615724,4:6303000:T>C,NM_006005.3:c.1478T>C,NP_005996.2:p.Val493Ala,8/8,\N,Unknown significance,\N,missense_variant,15.25,0.000386026,EXAC_AFR_AF,WFS1
615725,4:6303001:C>T,NM_006005.3:c.1479C>T,NP_005996.2:p.Val493=,8/8,\N,Unknown significance,\N,synonymous_variant,10.36,0.000172861,EXAC_AMR_AF,WFS1
615726,4:6303002:G>A,NM_006005.3:c.1480G>A,NP_005996.2:p.Gly494Ser,8/8,\N,Unknown significance,\N,missense_variant,26.5,0.000346981,EXAC_EAS_AF,WFS1
615727,4:6303005:C>G,NM_006005.3:c.1483C>G,NP_005996.2:p.His495Asp,8/8,\N,Unknown significance,\N,missense_variant,8.016,0.000015011,EXAC_NFE_AF,WFS1
615728,4:6303005:C>T,NM_006005.3:c.1483C>T,NP_005996.2:p.His495Tyr,8/8,\N,Unknown significance,\N,missense_variant,23.8,0.000015011,EXAC_NFE_AF,WFS1
615729,4:6303007:C>T,NM_006005.3:c.1485C>T,NP_005996.2:p.His495=,8/8,\N,Unknown significance,\N,synonymous_variant,3.953,0.001,1KG_SAS_AF,WFS1
615730,4:6303008:C>A,NM_006005.3:c.1486C>A,NP_005996.2:p.Leu496Met,8/8,\N,Likely benign,\N,missense_variant,0.21,0.0000150096,EXAC_NFE_AF,WFS1
615731,4:6303011:G>C,NM_006005.3:c.1489G>C,NP_005996.2:p.Val497Leu,8/8,\N,Likely benign,\N,missense_variant,0.346,0.000226963,EVS_AA_AF,WFS1
615732,4:6303013:C>T,NM_006005.3:c.1491C>T,NP_005996.2:p.Val497=,8/8,\N,Benign,\N,synonymous_variant,8.632,0.0076,1KG_AFR_AF,WFS1
615733,4:6303014:G>A,NM_006005.3:c.1492G>A,NP_005996.2:p.Val498Ile,8/8,\N,Likely benign,\N,missense_variant,0.008,0.0008,1KG_AFR_AF,WFS1
615734,4:6303014:GTCC>G,NM_006005.3:c.1495_1497del,NP_005996.2:p.Leu499del,8/8,\N,Unknown significance,\N,inframe_deletion,3.626,0.0000150114,EXAC_NFE_AF,WFS1
615735,4:6303016:C>T,NM_006005.3:c.1494C>T,NP_005996.2:p.Val498=,8/8,\N,Unknown significance,\N,synonymous_variant,4.31,0.000289296,EXAC_AFR_AF,WFS1
615736,4:6303017:C>T,NM_006005.3:c.1495C>T,NP_005996.2:p.Leu499Phe,8/8,\N,Benign,\N,missense_variant,1.918,0.0287,1KG_AFR_AF,WFS1
615737,4:6303019:C>T,NM_006005.3:c.1497C>T,NP_005996.2:p.Leu499=,8/8,\N,Unknown significance,\N,synonymous_variant,0.068,0.0000605694,EXAC_SAS_AF,WFS1
615738,4:6303020:AACG>A,NM_006005.3:c.1499_1501del,NP_005996.2:p.Asn500_Val501delinsIle,8/8,\N,Unknown significance,\N,inframe_deletion,8.131,0.0000150114,EXAC_NFE_AF,WFS1
615739,4:6303021:A>T,NM_006005.3:c.1499A>T,NP_005996.2:p.Asn500Ile,8/8,\N,Unknown significance,\N,missense_variant,23.4,0.0000864006,EXAC_AMR_AF,WFS1
615740,4:6303022:C>T,NM_006005.3:c.1500C>T,NP_005996.2:p.Asn500=,8/8,\N,Benign,\N,synonymous_variant,0.924,0.944059,EXAC_EAS_AF,WFS1
615741,4:6303022:C>A,NM_006005.3:c.1500C>A,NP_005996.2:p.Asn500Lys,8/8,\N,Likely benign,\N,missense_variant,12.39,\N,\N,WFS1
615742,4:6303022:C>G,NM_006005.3:c.1500C>G,NP_005996.2:p.Asn500Lys,8/8,\N,Likely benign,\N,missense_variant,9.519,\N,\N,WFS1
615743,4:6303025:C>T,NM_006005.3:c.1503C>T,NP_005996.2:p.Val501=,8/8,\N,Unknown significance,\N,synonymous_variant,0.339,0.0000963391,EXAC_AFR_AF,WFS1
615744,4:6303026:AGCGTCCCGTGCCT>A,NM_006005.3:c.1507_1519del,NP_005996.2:p.Val503SerfsTer15,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,29.7,\N,\N,WFS1
615745,4:6303028:C>A,NM_006005.3:c.1506C>A,NP_005996.2:p.Ser502Arg,8/8,\N,Unknown significance,\N,missense_variant,24.3,0.0000605694,EXAC_SAS_AF,WFS1
615746,4:6303028:C>T,NM_006005.3:c.1506C>T,NP_005996.2:p.Ser502=,8/8,\N,Unknown significance,\N,synonymous_variant,6.922,0.000181708,EXAC_SAS_AF,WFS1
615747,4:6303029:G>A,NM_006005.3:c.1507G>A,NP_005996.2:p.Val503Ile,8/8,\N,Likely benign,\N,missense_variant,0.001,0.002,1KG_EAS_AF,WFS1
615748,4:6303030:T>G,NM_006005.3:c.1508T>G,NP_005996.2:p.Val503Gly,8/8,\N,Benign,\N,missense_variant,14.11,0.005,OTO_JP_AF,WFS1
615749,4:6303033:C>T,NM_006005.3:c.1511C>T,NP_005996.2:p.Pro504Leu,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23.5,0.000172861,EXAC_AMR_AF,WFS1
615750,4:6303033:C>G,NM_006005.3:c.1511C>G,NP_005996.2:p.Pro504Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,15.35,\N,\N,WFS1
615751,4:6303034:G>A,NM_006005.3:c.1512G>A,NP_005996.2:p.Pro504=,8/8,\N,Unknown significance,\N,synonymous_variant,0.281,0.00016524,EXAC_NFE_AF,WFS1
615752,4:6303036:GCCTGCTCTATGTCTA>G,NM_006005.3:c.1525_1539del,NP_005996.2:p.Val509_Tyr513del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,13.21,\N,\N,WFS1
615753,4:6303036:G>A,NM_006005.3:c.1514G>A,NP_005996.2:p.Cys505Tyr,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23.1,\N,\N,WFS1
615754,4:6303039:T>G,NM_006005.3:c.1517T>G,NP_005996.2:p.Leu506Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23.7,\N,\N,WFS1
615755,4:6303040:G>A,NM_006005.3:c.1518G>A,NP_005996.2:p.Leu506=,8/8,\N,Unknown significance,\N,synonymous_variant,0.006,0.001,1KG_EUR_AF,WFS1
615756,4:6303043:C>G,NM_006005.3:c.1521C>G,NP_005996.2:p.Leu507=,8/8,\N,Unknown significance,\N,synonymous_variant,0.005,0.0000605914,EXAC_SAS_AF,WFS1
615757,4:6303043:CTA>C,NM_006005.3:c.1523_1524del,NP_005996.2:p.Tyr508CysfsTer34,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,27.1,0.0000150186,EXAC_NFE_AF,WFS1
615758,4:6303045:ATGTCTACCTGCTC>A,NM_006005.3:c.1525_1537del,NP_005996.2:p.Val509IlefsTer9,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,34,\N,\N,WFS1
615759,4:6303047:GTCTACCTGCTCTATC>G,NM_006005.3:c.1529_1543del,NP_005996.2:p.Tyr510_Leu514del,8/8,\N,Unknown significance,\N,inframe_deletion,14.58,\N,\N,WFS1
615760,4:6303048:T>G,NM_006005.3:c.1526T>G,NP_005996.2:p.Val509Gly,8/8,\N,Likely pathogenic,Diabetes| MODY,missense_variant,9.191,0.000578168,EXAC_EAS_AF,WFS1
615761,4:6303049:C>G,NM_006005.3:c.1527C>G,NP_005996.2:p.Val509=,8/8,\N,Unknown significance,\N,synonymous_variant,3.226,0.0000605767,EXAC_SAS_AF,WFS1
615762,4:6303051:A>G,NM_006005.3:c.1529A>G,NP_005996.2:p.Tyr510Cys,8/8,\N,Unknown significance,\N,missense_variant,24.9,0.0000605694,EXAC_SAS_AF,WFS1
615763,4:6303052:C>T,NM_006005.3:c.1530C>T,NP_005996.2:p.Tyr510=,8/8,\N,Benign,\N,synonymous_variant,1.917,0.0106,1KG_AFR_AF,WFS1
615764,4:6303053:C>T,NM_006005.3:c.1531C>T,NP_005996.2:p.Leu511=,8/8,\N,Unknown significance,\N,synonymous_variant,4.963,0.0008,1KG_AFR_AF,WFS1
615765,4:6303054:T>C,NM_006005.3:c.1532T>C,NP_005996.2:p.Leu511Pro,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.1,\N,\N,WFS1
615766,4:6303058:C>G,NM_006005.3:c.1536C>G,NP_005996.2:p.Leu512=,8/8,\N,Unknown significance,\N,synonymous_variant,4.078,\N,\N,WFS1
615767,4:6303060:A>C,NM_006005.3:c.1538A>C,NP_005996.2:p.Tyr513Ser,8/8,\N,Unknown significance,\N,missense_variant,22.5,0.00110375,EXAC_OTH_AF,WFS1
615768,4:6303060:A>G,NM_006005.3:c.1538A>G,NP_005996.2:p.Tyr513Cys,8/8,\N,Unknown significance,\N,missense_variant,22.8,0.00110375,EXAC_OTH_AF,WFS1
615769,4:6303062:C>T,NM_006005.3:c.1540C>T,NP_005996.2:p.Leu514Phe,8/8,\N,Unknown significance,\N,missense_variant,24.6,0.0000150231,EXAC_NFE_AF,WFS1
615770,4:6303062:CTCT>C,NM_006005.3:c.1546_1548del,NP_005996.2:p.Phe516del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,13.3,0.0000150231,EXAC_NFE_AF,WFS1
615771,4:6303069:TC>T,NM_006005.3:c.1549del,NP_005996.2:p.Arg517AlafsTer5,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,32,\N,\N,WFS1
615772,4:6303071:C>T,NM_006005.3:c.1549C>T,NP_005996.2:p.Arg517Cys,8/8,\N,Unknown significance,\N,missense_variant,25.7,0.000226963,EVS_AA_AF,WFS1
615773,4:6303072:G>A,NM_006005.3:c.1550G>A,NP_005996.2:p.Arg517His,8/8,\N,Unknown significance,\N,missense_variant,28.9,0.001,1KG_EAS_AF,WFS1
615774,4:6303072:G>C,NM_006005.3:c.1550G>C,NP_005996.2:p.Arg517Pro,8/8,\N,Unknown significance,\N,missense_variant,28.4,0.000226963,EVS_AA_AF,WFS1
615775,4:6303074:A>G,NM_006005.3:c.1552A>G,NP_005996.2:p.Met518Val,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,19.14,0.0000300454,EXAC_NFE_AF,WFS1
615776,4:6303075:T>A,NM_006005.3:c.1553T>A,NP_005996.2:p.Met518Lys,8/8,\N,Unknown significance,\N,missense_variant,25.6,0.000181708,EXAC_SAS_AF,WFS1
615777,4:6303076:G>A,NM_006005.3:c.1554G>A,NP_005996.2:p.Met518Ile,8/8,\N,Benign,\N,missense_variant,19.24,0.00771675,EVS_AA_AF,WFS1
615778,4:6303078:C>T,NM_006005.3:c.1556C>T,NP_005996.2:p.Ala519Val,8/8,\N,Unknown significance,\N,missense_variant,27.6,0.0014,1KG_AMR_AF,WFS1
615779,4:6303080:C>G,NM_006005.3:c.1558C>G,NP_005996.2:p.Gln520Glu,8/8,\N,Likely benign,\N,missense_variant,9.113,0.00110375,EXAC_OTH_AF,WFS1
615780,4:6303080:C>T,NM_006005.3:c.1558C>T,NP_005996.2:p.Gln520Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,38,\N,\N,WFS1
615781,4:6303082:G>A,NM_006005.3:c.1560G>A,NP_005996.2:p.Gln520=,8/8,\N,Unknown significance,\N,synonymous_variant,0.334,0.00221239,EXAC_OTH_AF,WFS1
615782,4:6303083:C>G,NM_006005.3:c.1561C>G,NP_005996.2:p.Leu521Val,8/8,\N,Unknown significance,\N,missense_variant,21.6,0.0000300454,EXAC_NFE_AF,WFS1
615783,4:6303099:G>A,NM_006005.3:c.1577G>A,NP_005996.2:p.Gly526Asp,8/8,\N,Unknown significance,\N,missense_variant,25.8,0.0000150209,EXAC_NFE_AF,WFS1
615784,4:6303100:C>T,NM_006005.3:c.1578C>T,NP_005996.2:p.Gly526=,8/8,\N,Unknown significance,\N,synonymous_variant,6.569,0.000226963,EVS_AA_AF,WFS1
615785,4:6303101:A>AC,NM_006005.3:c.1581dup,NP_005996.2:p.Tyr528LeufsTer15,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,28.4,\N,\N,WFS1
615786,4:6303102:C>T,NM_006005.3:c.1580C>T,NP_005996.2:p.Thr527Ile,8/8,\N,Unknown significance,\N,missense_variant,15.14,0.000302389,EXAC_FIN_AF,WFS1
615787,4:6303103:C>G,NM_006005.3:c.1581C>G,NP_005996.2:p.Thr527=,8/8,\N,Unknown significance,\N,synonymous_variant,3.784,0.0000150182,EXAC_NFE_AF,WFS1
615788,4:6303103:C>T,NM_006005.3:c.1581C>T,NP_005996.2:p.Thr527=,8/8,\N,Unknown significance,\N,synonymous_variant,6.632,0.0000300363,EXAC_NFE_AF,WFS1
615789,4:6303104:T>C,NM_006005.3:c.1582T>C,NP_005996.2:p.Tyr528His,8/8,\N,Unknown significance,\N,missense_variant,24.4,0.0000150177,EXAC_NFE_AF,WFS1
615790,4:6303104:T>G,NM_006005.3:c.1582T>G,NP_005996.2:p.Tyr528Asp,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.6,\N,\N,WFS1
615791,4:6303106:C>G,NM_006005.3:c.1584C>G,NP_005996.2:p.Tyr528Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,36,0.0000150191,EXAC_NFE_AF,WFS1
615792,4:6303108:G>GCTAC,NM_006005.3:c.1589_1592dup,NP_005996.2:p.Val532ProfsTer12,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,32,\N,\N,WFS1
615793,4:6303109:C>G,NM_006005.3:c.1587C>G,NP_005996.2:p.Cys529Trp,8/8,\N,Unknown significance,\N,missense_variant,24.6,0.0000150168,EXAC_NFE_AF,WFS1
615794,4:6303112:C>T,NM_006005.3:c.1590C>T,NP_005996.2:p.Tyr530=,8/8,\N,Unknown significance,\N,synonymous_variant,2.903,0.0000150168,EXAC_NFE_AF,WFS1
615795,4:6303113:C>T,NM_006005.3:c.1591C>T,NP_005996.2:p.Leu531Phe,8/8,\N,Unknown significance,\N,missense_variant,25.4,0.0000605694,EXAC_SAS_AF,WFS1
615796,4:6303114:T>G,NM_006005.3:c.1592T>G,NP_005996.2:p.Leu531Arg,8/8,\N,Unknown significance,\N,missense_variant,25.7,0.0000864006,EXAC_AMR_AF,WFS1
615797,4:6303116:G>T,NM_006005.3:c.1594G>T,NP_005996.2:p.Val532Leu,8/8,\N,Unknown significance,\N,missense_variant,23.7,0.000115607,EXAC_EAS_AF,WFS1
615798,4:6303119:C>T,NM_006005.3:c.1597C>T,NP_005996.2:p.Pro533Ser,8/8,\N,Unknown significance,\N,missense_variant,26.2,0.003125,OTO_CO_AF,WFS1
615799,4:6303124:C>T,NM_006005.3:c.1602C>T,NP_005996.2:p.Tyr534=,8/8,\N,Unknown significance,\N,synonymous_variant,3.325,0.0000300273,EXAC_NFE_AF,WFS1
615800,4:6303124:C>G,NM_006005.3:c.1602C>G,NP_005996.2:p.Tyr534Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,38,\N,\N,WFS1
615801,4:6303125:CTGGTGTGCTTCATG>C,NM_006005.3:c.1611_1624del,NP_005996.2:p.Cys537Ter,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
615802,4:6303127:G>A,NM_006005.3:c.1605G>A,NP_005996.2:p.Leu535=,8/8,\N,Unknown significance,\N,synonymous_variant,2.535,\N,\N,WFS1
615803,4:6303130:G>C,NM_006005.3:c.1608G>C,NP_005996.2:p.Val536=,8/8,\N,Unknown significance,\N,synonymous_variant,0.851,0.0000605694,EXAC_SAS_AF,WFS1
615804,4:6303132:G>A,NM_006005.3:c.1610G>A,NP_005996.2:p.Cys537Tyr,8/8,\N,Likely pathogenic,\N,missense_variant,25.4,0.0023,1KG_AFR_AF,WFS1
615805,4:6303132:GC>G,NM_006005.3:c.1611del,NP_005996.2:p.Phe538SerfsTer87,8/8,\N,Unknown significance,\N,frameshift_variant,31,0.0000150119,EXAC_NFE_AF,WFS1
615806,4:6303133:C>T,NM_006005.3:c.1611C>T,NP_005996.2:p.Cys537=,8/8,\N,Unknown significance,\N,synonymous_variant,4.65,0.0000605694,EXAC_SAS_AF,WFS1
615807,4:6303138:TGTG>T,NM_006005.3:c.1620_1622del,NP_005996.2:p.Trp540del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,17.72,\N,\N,WFS1
615808,4:6303141:G>A,NM_006005.3:c.1619G>A,NP_005996.2:p.Trp540Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,38,\N,\N,WFS1
615809,4:6303145:T>G,NM_006005.3:c.1623T>G,NP_005996.2:p.Cys541Trp,8/8,\N,Unknown significance,\N,missense_variant,13.49,0.0000150078,EXAC_NFE_AF,WFS1
615810,4:6303150:T>G,NM_006005.3:c.1628T>G,NP_005996.2:p.Leu543Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.6,\N,\N,WFS1
615811,4:6303151:C>T,NM_006005.3:c.1629C>T,NP_005996.2:p.Leu543=,8/8,\N,Unknown significance,\N,synonymous_variant,7.105,0.00019253,EXAC_AFR_AF,WFS1
615812,4:6303153:C>T,NM_006005.3:c.1631C>T,NP_005996.2:p.Ser544Phe,8/8,\N,Likely benign,\N,missense_variant,24.5,0.000226963,EVS_AA_AF,WFS1
615813,4:6303153:C>G,NM_006005.3:c.1631C>G,NP_005996.2:p.Ser544Cys,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,20.7,\N,\N,WFS1
615814,4:6303154:C>T,NM_006005.3:c.1632C>T,NP_005996.2:p.Ser544=,8/8,\N,Likely benign,\N,synonymous_variant,8.804,0.002,1KG_EAS_AF,WFS1
615815,4:6303155:G>A,NM_006005.3:c.1633G>A,NP_005996.2:p.Val545Met,8/8,\N,Unknown significance,\N,missense_variant,25.7,0.000115634,EXAC_EAS_AF,WFS1
615816,4:6303158:G>C,NM_006005.3:c.1636G>C,NP_005996.2:p.Val546Leu,8/8,\N,Unknown significance,\N,missense_variant,18.89,0.000115607,EXAC_EAS_AF,WFS1
615817,4:6303159:T>A,NM_006005.3:c.1637T>A,NP_005996.2:p.Val546Asp,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,22.8,\N,\N,WFS1
615818,4:6303164:C>A,NM_006005.3:c.1642C>A,NP_005996.2:p.Leu548Met,8/8,\N,Unknown significance,\N,missense_variant,23.3,0.0000150065,EXAC_NFE_AF,WFS1
615819,4:6303166:G>A,NM_006005.3:c.1644G>A,NP_005996.2:p.Leu548=,8/8,\N,Unknown significance,\N,synonymous_variant,1.497,0.0000150065,EXAC_NFE_AF,WFS1
615820,4:6303166:G>C,NM_006005.3:c.1644G>C,NP_005996.2:p.Leu548=,8/8,\N,Unknown significance,\N,synonymous_variant,0.223,\N,\N,WFS1
615821,4:6303167:C>G,NM_006005.3:c.1645C>G,NP_005996.2:p.Leu549Val,8/8,\N,Unknown significance,\N,missense_variant,8.299,\N,\N,WFS1
615822,4:6303167:C>T,NM_006005.3:c.1645C>T,NP_005996.2:p.Leu549=,8/8,\N,Unknown significance,\N,synonymous_variant,6.404,\N,\N,WFS1
615823,4:6303168:T>C,NM_006005.3:c.1646T>C,NP_005996.2:p.Leu549Pro,8/8,\N,Unknown significance,\N,missense_variant,22.6,0.0000962464,EXAC_AFR_AF,WFS1
615824,4:6303171:A>C,NM_006005.3:c.1649A>C,NP_005996.2:p.Glu550Ala,8/8,\N,Unknown significance,\N,missense_variant,14.47,0.0000864006,EXAC_AMR_AF,WFS1
615825,4:6303175:C>T,NM_006005.3:c.1653C>T,NP_005996.2:p.Ser551=,8/8,\N,Unknown significance,\N,synonymous_variant,7.035,0.000060042,EXAC_NFE_AF,WFS1
615826,4:6303176:A>C,NM_006005.3:c.1654A>C,NP_005996.2:p.Thr552Pro,8/8,\N,Benign,\N,missense_variant,23.9,0.01,OTO_TR_AF,WFS1
615827,4:6303178:C>G,NM_006005.3:c.1656C>G,NP_005996.2:p.Thr552=,8/8,\N,Unknown significance,\N,synonymous_variant,7.633,0.000115607,EXAC_EAS_AF,WFS1
615828,4:6303178:C>T,NM_006005.3:c.1656C>T,NP_005996.2:p.Thr552=,8/8,\N,Unknown significance,\N,synonymous_variant,10.76,0.0008,1KG_AFR_AF,WFS1
615829,4:6303179:G>A,NM_006005.3:c.1657G>A,NP_005996.2:p.Gly553Ser,8/8,\N,Likely benign,\N,missense_variant,13.99,0.000302389,EXAC_FIN_AF,WFS1
615830,4:6303179:G>T,NM_006005.3:c.1657G>T,NP_005996.2:p.Gly553Cys,8/8,\N,Unknown significance,\N,missense_variant,17.15,0.0000450261,EXAC_NFE_AF,WFS1
615831,4:6303182:C>A,NM_006005.3:c.1660C>A,NP_005996.2:p.Leu554Met,8/8,\N,Unknown significance,\N,missense_variant,22.7,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
615832,4:6303184:G>A,NM_006005.3:c.1662G>A,NP_005996.2:p.Leu554=,8/8,\N,Unknown significance,\N,synonymous_variant,0.262,\N,\N,WFS1
615833,4:6303185:G>A,NM_006005.3:c.1663G>A,NP_005996.2:p.Gly555Arg,8/8,\N,Unknown significance,\N,missense_variant,25.5,0.0000150096,EXAC_NFE_AF,WFS1
615834,4:6303188:C>T,NM_006005.3:c.1666C>T,NP_005996.2:p.Leu556=,8/8,\N,Unknown significance,\N,synonymous_variant,6.056,0.0000864006,EXAC_AMR_AF,WFS1
615835,4:6303191:C>T,NM_006005.3:c.1669C>T,NP_005996.2:p.Leu557Phe,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,15.78,0.000192938,EXAC_AFR_AF,WFS1
615836,4:6303193:C>G,NM_006005.3:c.1671C>G,NP_005996.2:p.Leu557=,8/8,\N,Unknown significance,\N,synonymous_variant,1.551,0.000231214,EXAC_EAS_AF,WFS1
615837,4:6303193:C>T,NM_006005.3:c.1671C>T,NP_005996.2:p.Leu557=,8/8,\N,Unknown significance,\N,synonymous_variant,5.826,0.000121124,EXAC_SAS_AF,WFS1
615838,4:6303194:C>T,NM_006005.3:c.1672C>T,NP_005996.2:p.Arg558Cys,8/8,\N,Unknown significance,\N,missense_variant,30,0.0025,OTO_AJ_AF,WFS1
615839,4:6303194:C>A,NM_006005.3:c.1672C>A,NP_005996.2:p.Arg558Ser,8/8,\N,Unknown significance,\N,missense_variant,28,0.000151194,EXAC_FIN_AF,WFS1
615840,4:6303195:G>A,NM_006005.3:c.1673G>A,NP_005996.2:p.Arg558His,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,27.7,0.000115607,EXAC_EAS_AF,WFS1
615841,4:6303196:C>T,NM_006005.3:c.1674C>T,NP_005996.2:p.Arg558=,8/8,\N,Benign,\N,synonymous_variant,5.54,0.0106,1KG_AFR_AF,WFS1
615842,4:6303197:G>A,NM_006005.3:c.1675G>A,NP_005996.2:p.Ala559Thr,8/8,\N,Benign,\N,missense_variant,21.6,0.0125,OTO_US_AF,WFS1
615843,4:6303198:C>G,NM_006005.3:c.1676C>G,NP_005996.2:p.Ala559Gly,8/8,\N,Likely benign,\N,missense_variant,16.85,\N,\N,WFS1
615844,4:6303198:C>T,NM_006005.3:c.1676C>T,NP_005996.2:p.Ala559Val,8/8,\N,Unknown significance,\N,missense_variant,25.8,0.0000864006,EXAC_AMR_AF,WFS1
615845,4:6303198:C>A,NM_006005.3:c.1676C>A,NP_005996.2:p.Ala559Asp,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,26,\N,\N,WFS1
615846,4:6303202:C>G,NM_006005.3:c.1680C>G,NP_005996.2:p.Ser560=,8/8,\N,Unknown significance,\N,synonymous_variant,0.928,0.0000300327,EXAC_NFE_AF,WFS1
615847,4:6303203:A>G,NM_006005.3:c.1681A>G,NP_005996.2:p.Ile561Val,8/8,\N,Likely benign,\N,missense_variant,0.001,0.000346821,EXAC_EAS_AF,WFS1
615848,4:6303204:T>G,NM_006005.3:c.1682T>G,NP_005996.2:p.Ile561Ser,8/8,\N,Unknown significance,\N,missense_variant,22.5,0.00110375,EXAC_OTH_AF,WFS1
615849,4:6303205:C>T,NM_006005.3:c.1683C>T,NP_005996.2:p.Ile561=,8/8,\N,Benign,\N,synonymous_variant,10.52,0.0603,1KG_SAS_AF,WFS1
615850,4:6303205:C>G,NM_006005.3:c.1683C>G,NP_005996.2:p.Ile561Met,8/8,\N,Likely benign,\N,missense_variant,0.957,0.000115607,EXAC_EAS_AF,WFS1
615851,4:6303206:G>C,NM_006005.3:c.1684G>C,NP_005996.2:p.Gly562Arg,8/8,\N,Likely pathogenic,\N,missense_variant,26.5,\N,\N,WFS1
615852,4:6303206:G>A,NM_006005.3:c.1684G>A,NP_005996.2:p.Gly562Ser,8/8,\N,Unknown significance,\N,missense_variant,24.8,0.000193125,EXAC_AFR_AF,WFS1
615853,4:6303210:ACTTCCT>A,NM_006005.3:c.1698_1703del,NP_005996.2:p.Leu567_Phe568del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,15,0.000060562,EXAC_SAS_AF,WFS1
615854,4:6303214:C>G,NM_006005.3:c.1692C>G,NP_005996.2:p.Phe564Leu,8/8,\N,Likely benign,\N,missense_variant,10.17,0.000453926,EVS_AA_AF,WFS1
615855,4:6303214:C>T,NM_006005.3:c.1692C>T,NP_005996.2:p.Phe564=,8/8,\N,Unknown significance,\N,synonymous_variant,9.197,0.0000150164,EXAC_NFE_AF,WFS1
615856,4:6303215:C>G,NM_006005.3:c.1693C>G,NP_005996.2:p.Leu565Val,8/8,\N,Unknown significance,\N,missense_variant,23.3,0.0043,1KG_AMR_AF,WFS1
615857,4:6303217:C>T,NM_006005.3:c.1695C>T,NP_005996.2:p.Leu565=,8/8,\N,Unknown significance,\N,synonymous_variant,7.893,0.000240262,EXAC_NFE_AF,WFS1
615858,4:6303220:CCTCTTT>C,NM_006005.3:c.1699_1704del,NP_005996.2:p.Leu567_Phe568del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,14.55,0.0000605694,EXAC_SAS_AF,WFS1
615859,4:6303220:C>T,NM_006005.3:c.1698C>T,NP_005996.2:p.Phe566=,8/8,\N,Unknown significance,\N,synonymous_variant,9.352,0.000172801,EXAC_AMR_AF,WFS1
615860,4:6303220:C>A,NM_006005.3:c.1698C>A,NP_005996.2:p.Phe566Leu,8/8,\N,Unknown significance,\N,missense_variant,22.1,0.0000150092,EXAC_NFE_AF,WFS1
615861,4:6303224:T>TTTGCCCTCCC,NM_006005.3:c.1703_1712dup,NP_005996.2:p.Ile572CysfsTer37,8/8,\N,Unknown significance,\N,frameshift_variant,33,\N,\N,WFS1
615862,4:6303225:T>C,NM_006005.3:c.1703T>C,NP_005996.2:p.Phe568Ser,8/8,\N,Unknown significance,\N,missense_variant,23.9,\N,\N,WFS1
615863,4:6303227:GC>AG,NM_006005.3:c.1705_1706delinsAG,NP_005996.2:p.Ala569Ser,8/8,\N,Likely pathogenic,Cerebellar ataxia,missense_variant,12.7,\N,\N,WFS1
615864,4:6303228:C>T,NM_006005.3:c.1706C>T,NP_005996.2:p.Ala569Val,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,22.1,0.00183824,EXAC_AFR_AF,WFS1
615865,4:6303235:C>G,NM_006005.3:c.1713C>G,NP_005996.2:p.Pro571=,8/8,\N,Unknown significance,\N,synonymous_variant,1.75,\N,\N,WFS1
615866,4:6303239:C>G,NM_006005.3:c.1717C>G,NP_005996.2:p.Leu573Val,8/8,\N,Unknown significance,\N,missense_variant,9.233,0.0000600402,EXAC_NFE_AF,WFS1
615867,4:6303244:G>A,NM_006005.3:c.1722G>A,NP_005996.2:p.Val574=,8/8,\N,Unknown significance,\N,synonymous_variant,2.309,0.0000864006,EXAC_AMR_AF,WFS1
615868,4:6303246:C>G,NM_006005.3:c.1724C>G,NP_005996.2:p.Ala575Gly,8/8,\N,Unknown significance,\N,missense_variant,22.3,0.0022468,EXAC_AMR_AF,WFS1
615869,4:6303247:C>T,NM_006005.3:c.1725C>T,NP_005996.2:p.Ala575=,8/8,\N,Benign,\N,synonymous_variant,14.08,0.1275,OTO_AJ_AF,WFS1
615870,4:6303247:C>G,NM_006005.3:c.1725C>G,NP_005996.2:p.Ala575=,8/8,\N,Unknown significance,\N,synonymous_variant,10.84,0.000096768,EXAC_AFR_AF,WFS1
615871,4:6303248:G>A,NM_006005.3:c.1726G>A,NP_005996.2:p.Gly576Ser,8/8,\N,Benign,\N,missense_variant,27.3,0.1175,OTO_JP_AF,WFS1
615872,4:6303248:G>T,NM_006005.3:c.1726G>T,NP_005996.2:p.Gly576Cys,8/8,\N,Unknown significance,\N,missense_variant,28.6,0.0000300201,EXAC_NFE_AF,WFS1
615873,4:6303250:C>A,NM_006005.3:c.1728C>A,NP_005996.2:p.Gly576=,8/8,\N,Unknown significance,\N,synonymous_variant,10.72,0.000116279,EVS_EA_AF,WFS1
615874,4:6303250:C>G,NM_006005.3:c.1728C>G,NP_005996.2:p.Gly576=,8/8,\N,Unknown significance,\N,synonymous_variant,4.657,0.000015006,EXAC_NFE_AF,WFS1
615875,4:6303253:G>A,NM_006005.3:c.1731G>A,NP_005996.2:p.Leu577=,8/8,\N,Unknown significance,\N,synonymous_variant,0.801,0.0000150083,EXAC_NFE_AF,WFS1
615876,4:6303258:T>C,NM_006005.3:c.1736T>C,NP_005996.2:p.Leu579Pro,8/8,\N,Unknown significance,\N,missense_variant,22,0.0014,1KG_AMR_AF,WFS1
615877,4:6303259:G>A,NM_006005.3:c.1737G>A,NP_005996.2:p.Leu579=,8/8,\N,Unknown significance,\N,synonymous_variant,0.015,0.0015,1KG_AFR_AF,WFS1
615878,4:6303261:T>A,NM_006005.3:c.1739T>A,NP_005996.2:p.Val580Glu,8/8,\N,Unknown significance,\N,missense_variant,21.3,0.000348837,EVS_EA_AF,WFS1
615879,4:6303261:T>G,NM_006005.3:c.1739T>G,NP_005996.2:p.Val580Gly,8/8,\N,Unknown significance,\N,missense_variant,15.87,0.0000150029,EXAC_NFE_AF,WFS1
615880,4:6303262:G>A,NM_006005.3:c.1740G>A,NP_005996.2:p.Val580=,8/8,\N,Unknown significance,\N,synonymous_variant,0.448,0.000259246,EXAC_AMR_AF,WFS1
615881,4:6303262:G>T,NM_006005.3:c.1740G>T,NP_005996.2:p.Val580=,8/8,\N,Unknown significance,\N,synonymous_variant,0.126,0.0000965065,EXAC_AFR_AF,WFS1
615882,4:6303263:G>T,NM_006005.3:c.1741G>T,NP_005996.2:p.Gly581Cys,8/8,\N,Unknown significance,\N,missense_variant,9.36,\N,\N,WFS1
615883,4:6303264:G>C,NM_006005.3:c.1742G>C,NP_005996.2:p.Gly581Ala,8/8,\N,Likely benign,\N,missense_variant,0.002,0.0000605694,EXAC_SAS_AF,WFS1
615884,4:6303265:C>T,NM_006005.3:c.1743C>T,NP_005996.2:p.Gly581=,8/8,\N,Likely benign,\N,synonymous_variant,7.714,0.00110375,EXAC_OTH_AF,WFS1
615885,4:6303266:G>A,NM_006005.3:c.1744G>A,NP_005996.2:p.Val582Met,8/8,\N,Likely benign,\N,missense_variant,3.029,0.000226963,EVS_AA_AF,WFS1
615886,4:6303266:G>T,NM_006005.3:c.1744G>T,NP_005996.2:p.Val582Leu,8/8,\N,Likely benign,\N,missense_variant,0.011,0.0000964134,EXAC_AFR_AF,WFS1
615887,4:6303274:G>A,NM_006005.3:c.1752G>A,NP_005996.2:p.Gln584=,8/8,\N,Unknown significance,\N,synonymous_variant,0.029,0.000226963,EVS_AA_AF,WFS1
615888,4:6303274:G>C,NM_006005.3:c.1752G>C,NP_005996.2:p.Gln584His,8/8,\N,Unknown significance,\N,missense_variant,9.589,0.0008,1KG_AFR_AF,WFS1
615889,4:6303277:C>T,NM_006005.3:c.1755C>T,NP_005996.2:p.Phe585=,8/8,\N,Unknown significance,\N,synonymous_variant,3.44,0.0015,1KG_AFR_AF,WFS1
615890,4:6303278:G>A,NM_006005.3:c.1756G>A,NP_005996.2:p.Ala586Thr,8/8,\N,Likely benign,\N,missense_variant,7.197,0.001,1KG_EAS_AF,WFS1
615891,4:6303278:G>T,NM_006005.3:c.1756G>T,NP_005996.2:p.Ala586Ser,8/8,\N,Likely benign,\N,missense_variant,5.746,0.000453926,EVS_AA_AF,WFS1
615892,4:6303279:C>G,NM_006005.3:c.1757C>G,NP_005996.2:p.Ala586Gly,8/8,\N,Likely benign,\N,missense_variant,13.69,0.0000605694,EXAC_SAS_AF,WFS1
615893,4:6303280:C>T,NM_006005.3:c.1758C>T,NP_005996.2:p.Ala586=,8/8,\N,Likely benign,\N,synonymous_variant,7.568,0.00110375,EXAC_OTH_AF,WFS1
615894,4:6303281:C>T,NM_006005.3:c.1759C>T,NP_005996.2:p.Arg587Trp,8/8,\N,Unknown significance,\N,missense_variant,25.3,0.002,1KG_SAS_AF,WFS1
615895,4:6303282:G>A,NM_006005.3:c.1760G>A,NP_005996.2:p.Arg587Gln,8/8,\N,Likely benign,\N,missense_variant,9.532,0.00198721,EXAC_AMR_AF,WFS1
615896,4:6303283:G>C,NM_006005.3:c.1761G>C,NP_005996.2:p.Arg587=,8/8,\N,Unknown significance,\N,synonymous_variant,0.512,0.0000962279,EXAC_AFR_AF,WFS1
615897,4:6303285:G>A,NM_006005.3:c.1763G>A,NP_005996.2:p.Trp588Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,37,\N,\N,WFS1
615898,4:6303286:G>A,NM_006005.3:c.1764G>A,NP_005996.2:p.Trp588Ter,8/8,\N,Unknown significance,\N,stop_gained,38,0.0000605694,EXAC_SAS_AF,WFS1
615899,4:6303286:G>T,NM_006005.3:c.1764G>T,NP_005996.2:p.Trp588Cys,8/8,\N,Unknown significance,\N,missense_variant,26.2,0.000172801,EXAC_AMR_AF,WFS1
615900,4:6303289:C>T,NM_006005.3:c.1767C>T,NP_005996.2:p.Phe589=,8/8,\N,Unknown significance,\N,synonymous_variant,1.77,0.0000864006,EXAC_AMR_AF,WFS1
615901,4:6303291:C>T,NM_006005.3:c.1769C>T,NP_005996.2:p.Thr590Met,8/8,\N,Likely benign,\N,missense_variant,14.08,0.000060562,EXAC_SAS_AF,WFS1
615902,4:6303292:G>A,NM_006005.3:c.1770G>A,NP_005996.2:p.Thr590=,8/8,\N,Unknown significance,\N,synonymous_variant,8.279,0.0008,1KG_AFR_AF,WFS1
615903,4:6303294:C>G,NM_006005.3:c.1772C>G,NP_005996.2:p.Ser591Cys,8/8,\N,Unknown significance,\N,missense_variant,23.9,\N,\N,WFS1
615904,4:6303294:C>T,NM_006005.3:c.1772C>T,NP_005996.2:p.Ser591Phe,8/8,\N,Unknown significance,\N,missense_variant,24.6,0.000060562,EXAC_SAS_AF,WFS1
615905,4:6303296:C>G,NM_006005.3:c.1774C>G,NP_005996.2:p.Leu592Val,8/8,\N,Unknown significance,\N,missense_variant,17.45,0.00110375,EXAC_OTH_AF,WFS1
615906,4:6303296:C>CTGGA,NM_006005.3:c.1775_1778dup,NP_005996.2:p.Glu593AspfsTer14,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,33,\N,\N,WFS1
615907,4:6303296:CTG>C,NM_006005.3:c.1775_1776del,NP_005996.2:p.Leu592ArgfsTer13,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,34,\N,\N,WFS1
615908,4:6303299:G>A,NM_006005.3:c.1777G>A,NP_005996.2:p.Glu593Lys,8/8,\N,Unknown significance,\N,missense_variant,22.3,\N,\N,WFS1
615909,4:6303299:G>C,NM_006005.3:c.1777G>C,NP_005996.2:p.Glu593Gln,8/8,\N,Unknown significance,\N,missense_variant,22.9,0.0000864006,EXAC_AMR_AF,WFS1
615910,4:6303300:A>G,NM_006005.3:c.1778A>G,NP_005996.2:p.Glu593Gly,8/8,\N,Unknown significance,\N,missense_variant,17.21,0.000226963,EVS_AA_AF,WFS1
615911,4:6303301:G>C,NM_006005.3:c.1779G>C,NP_005996.2:p.Glu593Asp,8/8,\N,Likely benign,\N,missense_variant,8.549,0.003,1KG_AFR_AF,WFS1
615912,4:6303303:T>G,NM_006005.3:c.1781T>G,NP_005996.2:p.Leu594Arg,8/8,\N,Unknown significance,\N,missense_variant,25.5,\N,\N,WFS1
615913,4:6303306:C>G,NM_006005.3:c.1784C>G,NP_005996.2:p.Thr595Ser,8/8,\N,Unknown significance,\N,missense_variant,15.36,0.000115554,EXAC_EAS_AF,WFS1
615914,4:6303306:C>T,NM_006005.3:c.1784C>T,NP_005996.2:p.Thr595Ile,8/8,\N,Unknown significance,\N,missense_variant,17.31,0.000226963,EVS_AA_AF,WFS1
615915,4:6303307:C>T,NM_006005.3:c.1785C>T,NP_005996.2:p.Thr595=,8/8,\N,Unknown significance,\N,synonymous_variant,5.052,0.0000149952,EXAC_NFE_AF,WFS1
615916,4:6303308:A>C,NM_006005.3:c.1786A>C,NP_005996.2:p.Lys596Gln,8/8,\N,Unknown significance,\N,missense_variant,24.5,0.000423934,EXAC_SAS_AF,WFS1
615917,4:6303310:G>C,NM_006005.3:c.1788G>C,NP_005996.2:p.Lys596Asn,8/8,\N,Unknown significance,\N,missense_variant,24.7,\N,\N,WFS1
615918,4:6303313:C>G,NM_006005.3:c.1791C>G,NP_005996.2:p.Ile597Met,8/8,\N,Likely benign,\N,missense_variant,2.883,0.000302389,EXAC_FIN_AF,WFS1
615919,4:6303313:C>T,NM_006005.3:c.1791C>T,NP_005996.2:p.Ile597=,8/8,\N,Unknown significance,\N,synonymous_variant,7.731,0.000453926,EVS_AA_AF,WFS1
615920,4:6303314:G>A,NM_006005.3:c.1792G>A,NP_005996.2:p.Ala598Thr,8/8,\N,Benign,\N,missense_variant,6.422,0.0068,1KG_AFR_AF,WFS1
615921,4:6303315:C>G,NM_006005.3:c.1793C>G,NP_005996.2:p.Ala598Gly,8/8,\N,Likely benign,\N,missense_variant,0.491,0.0000961169,EXAC_AFR_AF,WFS1
615922,4:6303315:C>T,NM_006005.3:c.1793C>T,NP_005996.2:p.Ala598Val,8/8,\N,Likely benign,\N,missense_variant,0.004,0.000014993,EXAC_NFE_AF,WFS1
615923,4:6303318:T>G,NM_006005.3:c.1796T>G,NP_005996.2:p.Val599Gly,8/8,\N,Unknown significance,\N,missense_variant,13.23,0.0000149934,EXAC_NFE_AF,WFS1
615924,4:6303319:C>A,NM_006005.3:c.1797C>A,NP_005996.2:p.Val599=,8/8,\N,Benign,\N,synonymous_variant,1.709,0.0378,1KG_AFR_AF,WFS1
615925,4:6303319:C>T,NM_006005.3:c.1797C>T,NP_005996.2:p.Val599=,8/8,\N,Unknown significance,\N,synonymous_variant,0.767,0.0000961169,EXAC_AFR_AF,WFS1
615926,4:6303322:C>T,NM_006005.3:c.1800C>T,NP_005996.2:p.Thr600=,8/8,\N,Benign,\N,synonymous_variant,6.643,0.0378,1KG_AFR_AF,WFS1
615927,4:6303322:C>A,NM_006005.3:c.1800C>A,NP_005996.2:p.Thr600=,8/8,\N,Unknown significance,\N,synonymous_variant,11.51,0.0000149921,EXAC_NFE_AF,WFS1
615928,4:6303323:G>A,NM_006005.3:c.1801G>A,NP_005996.2:p.Val601Met,8/8,\N,Likely benign,\N,missense_variant,0.002,0.000226963,EVS_AA_AF,WFS1
615929,4:6303323:G>T,NM_006005.3:c.1801G>T,NP_005996.2:p.Val601Leu,8/8,\N,Likely benign,\N,missense_variant,0.001,0.0000149916,EXAC_NFE_AF,WFS1
615930,4:6303327:C>T,NM_006005.3:c.1805C>T,NP_005996.2:p.Ala602Val,8/8,\N,Benign,\N,missense_variant,0.001,0.1082,1KG_AFR_AF,WFS1
615931,4:6303327:C>A,NM_006005.3:c.1805C>A,NP_005996.2:p.Ala602Glu,8/8,\N,Likely benign,\N,missense_variant,0.474,\N,\N,WFS1
615932,4:6303327:C>G,NM_006005.3:c.1805C>G,NP_005996.2:p.Ala602Gly,8/8,\N,Likely benign,\N,missense_variant,0.009,\N,\N,WFS1
615933,4:6303328:G>A,NM_006005.3:c.1806G>A,NP_005996.2:p.Ala602=,8/8,\N,Unknown significance,\N,synonymous_variant,0.041,0.002,1KG_SAS_AF,WFS1
615934,4:6303328:G>C,NM_006005.3:c.1806G>C,NP_005996.2:p.Ala602=,8/8,\N,Unknown significance,\N,synonymous_variant,0.008,0.0000299823,EXAC_NFE_AF,WFS1
615935,4:6303328:G>T,NM_006005.3:c.1806G>T,NP_005996.2:p.Ala602=,8/8,\N,Unknown significance,\N,synonymous_variant,0.015,0.000115554,EXAC_EAS_AF,WFS1
615936,4:6303329:G>A,NM_006005.3:c.1807G>A,NP_005996.2:p.Val603Ile,8/8,\N,Likely benign,\N,missense_variant,0.001,0.0008,1KG_AFR_AF,WFS1
615937,4:6303331:C>T,NM_006005.3:c.1809C>T,NP_005996.2:p.Val603=,8/8,\N,Unknown significance,\N,synonymous_variant,0.059,\N,\N,WFS1
615938,4:6303334:T>TA,NM_006005.3:c.1813dup,NP_005996.2:p.Ser605LysfsTer107,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,24.6,\N,\N,WFS1
615939,4:6303335:A>G,NM_006005.3:c.1813A>G,NP_005996.2:p.Ser605Gly,8/8,\N,Likely benign,\N,missense_variant,0.001,0.0000449694,EXAC_NFE_AF,WFS1
615940,4:6303336:G>A,NM_006005.3:c.1814G>A,NP_005996.2:p.Ser605Asn,8/8,\N,Benign,\N,missense_variant,0.011,0.005,OTO_TR_AF,WFS1
615941,4:6303338:G>A,NM_006005.3:c.1816G>A,NP_005996.2:p.Val606Met,8/8,\N,Unknown significance,\N,missense_variant,0.001,0.0000149912,EXAC_NFE_AF,WFS1
615942,4:6303338:G>C,NM_006005.3:c.1816G>C,NP_005996.2:p.Val606Leu,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,0.001,\N,\N,WFS1
615943,4:6303339:T>G,NM_006005.3:c.1817T>G,NP_005996.2:p.Val606Gly,8/8,\N,Unknown significance,\N,missense_variant,19.12,0.00220751,EXAC_OTH_AF,WFS1
615944,4:6303341:C>G,NM_006005.3:c.1819C>G,NP_005996.2:p.Pro607Ala,8/8,\N,Unknown significance,\N,missense_variant,17.48,0.000181686,EXAC_SAS_AF,WFS1
615945,4:6303341:C>T,NM_006005.3:c.1819C>T,NP_005996.2:p.Pro607Ser,8/8,\N,Unknown significance,\N,missense_variant,23.6,0.0000149903,EXAC_NFE_AF,WFS1
615946,4:6303342:C>T,NM_006005.3:c.1820C>T,NP_005996.2:p.Pro607Leu,8/8,\N,Likely benign,\N,missense_variant,24.6,0.000577768,EXAC_EAS_AF,WFS1
615947,4:6303342:C>G,NM_006005.3:c.1820C>G,NP_005996.2:p.Pro607Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23.5,\N,\N,WFS1
615948,4:6303343:C>T,NM_006005.3:c.1821C>T,NP_005996.2:p.Pro607=,8/8,\N,Unknown significance,\N,synonymous_variant,0.426,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
615949,4:6303344:C>T,NM_006005.3:c.1822C>T,NP_005996.2:p.Leu608=,8/8,\N,Unknown significance,\N,synonymous_variant,0.152,0.0000149889,EXAC_NFE_AF,WFS1
615950,4:6303347:C>T,NM_006005.3:c.1825C>T,NP_005996.2:p.Leu609=,8/8,\N,Unknown significance,\N,synonymous_variant,0.141,0.000116279,EVS_EA_AF,WFS1
615951,4:6303353:CG>TA,NM_006005.3:c.1831_1832delinsTA,NP_005996.2:p.Arg611Tyr,8/8,\N,Likely pathogenic,\N,missense_variant,\N,\N,\N,WFS1
615952,4:6303353:C>G,NM_006005.3:c.1831C>G,NP_005996.2:p.Arg611Gly,8/8,\N,Unknown significance,\N,missense_variant,15.15,0.000060562,EXAC_SAS_AF,WFS1
615953,4:6303353:C>T,NM_006005.3:c.1831C>T,NP_005996.2:p.Arg611Cys,8/8,\N,Unknown significance,\N,missense_variant,23.7,0.000348837,EVS_EA_AF,WFS1
615954,4:6303354:G>A,NM_006005.3:c.1832G>A,NP_005996.2:p.Arg611His,8/8,\N,Benign,\N,missense_variant,11.69,0.836343,EXAC_EAS_AF,WFS1
615955,4:6303355:C>T,NM_006005.3:c.1833C>T,NP_005996.2:p.Arg611=,8/8,\N,Unknown significance,\N,synonymous_variant,0.253,0.00011558,EXAC_EAS_AF,WFS1
615956,4:6303358:G>C,NM_006005.3:c.1836G>C,NP_005996.2:p.Trp612Cys,8/8,\N,Unknown significance,\N,missense_variant,8.641,0.000359723,EXAC_NFE_AF,WFS1
615957,4:6303360:G>A,NM_006005.3:c.1838G>A,NP_005996.2:p.Trp613Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,36,0.000121124,EXAC_SAS_AF,WFS1
615958,4:6303361:G>A,NM_006005.3:c.1839G>A,NP_005996.2:p.Trp613Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,36,0.000116279,EVS_EA_AF,WFS1
615959,4:6303363:C>G,NM_006005.3:c.1841C>G,NP_005996.2:p.Thr614Ser,8/8,\N,Likely benign,\N,missense_variant,0.094,0.0000149889,EXAC_NFE_AF,WFS1
615960,4:6303364:C>T,NM_006005.3:c.1842C>T,NP_005996.2:p.Thr614=,8/8,\N,Unknown significance,\N,synonymous_variant,0.602,0.0000149903,EXAC_NFE_AF,WFS1
615961,4:6303368:G>T,NM_006005.3:c.1846G>T,NP_005996.2:p.Ala616Ser,8/8,\N,Pathogenic,Sensorineural hearing loss| nonsyndromic,missense_variant,0.151,0.001,1KG_EAS_AF,WFS1
615962,4:6303370:C>T,NM_006005.3:c.1848C>T,NP_005996.2:p.Ala616=,8/8,\N,Unknown significance,\N,synonymous_variant,1.37,0.0000299787,EXAC_NFE_AF,WFS1
615963,4:6303379:T>C,NM_006005.3:c.1857T>C,NP_005996.2:p.Ser619=,8/8,\N,Unknown significance,\N,synonymous_variant,0.001,0.000226963,EVS_AA_AF,WFS1
615964,4:6303380:G>C,NM_006005.3:c.1858G>C,NP_005996.2:p.Val620Leu,8/8,\N,Likely benign,\N,missense_variant,0.04,0.00110132,EXAC_OTH_AF,WFS1
615965,4:6303381:T>C,NM_006005.3:c.1859T>C,NP_005996.2:p.Val620Ala,8/8,\N,Likely benign,\N,missense_variant,0.026,0.000060562,EXAC_SAS_AF,WFS1
615966,4:6303381:T>G,NM_006005.3:c.1859T>G,NP_005996.2:p.Val620Gly,8/8,\N,Likely benign,\N,missense_variant,2.916,0.0000863856,EXAC_AMR_AF,WFS1
615967,4:6303385:G>C,NM_006005.3:c.1863G>C,NP_005996.2:p.Val621=,8/8,\N,Unknown significance,\N,synonymous_variant,0.14,0.0000863856,EXAC_AMR_AF,WFS1
615968,4:6303387:G>T,NM_006005.3:c.1865G>T,NP_005996.2:p.Gly622Val,8/8,\N,Likely benign,\N,missense_variant,0.054,0.000096302,EXAC_AFR_AF,WFS1
615969,4:6303388:G>A,NM_006005.3:c.1866G>A,NP_005996.2:p.Gly622=,8/8,\N,Unknown significance,\N,synonymous_variant,0.51,\N,\N,WFS1
615970,4:6303390:T>C,NM_006005.3:c.1868T>C,NP_005996.2:p.Met623Thr,8/8,\N,Likely benign,\N,missense_variant,3.473,0.0000863856,EXAC_AMR_AF,WFS1
615971,4:6303391:G>A,NM_006005.3:c.1869G>A,NP_005996.2:p.Met623Ile,8/8,\N,Likely benign,\N,missense_variant,7.011,0.0000149898,EXAC_NFE_AF,WFS1
615972,4:6303393:T>C,NM_006005.3:c.1871T>C,NP_005996.2:p.Val624Ala,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,13.13,0.000288906,EXAC_AFR_AF,WFS1
615973,4:6303393:T>G,NM_006005.3:c.1871T>G,NP_005996.2:p.Val624Gly,8/8,\N,Benign,\N,missense_variant,16.16,0.005,OTO_TR_AF,WFS1
615974,4:6303399:C>T,NM_006005.3:c.1877C>T,NP_005996.2:p.Ser626Phe,8/8,\N,Unknown significance,\N,missense_variant,27,0.000060562,EXAC_SAS_AF,WFS1
615975,4:6303401:C>G,NM_006005.3:c.1879C>G,NP_005996.2:p.Leu627Val,8/8,\N,Unknown significance,\N,missense_variant,24.3,0.0000864006,EXAC_AMR_AF,WFS1
615976,4:6303405:C>G,NM_006005.3:c.1883C>G,NP_005996.2:p.Thr628Arg,8/8,\N,Unknown significance,\N,missense_variant,21.5,0.0000149912,EXAC_NFE_AF,WFS1
615977,4:6303405:C>T,NM_006005.3:c.1883C>T,NP_005996.2:p.Thr628Met,8/8,\N,Unknown significance,\N,missense_variant,25.1,0.000116279,EVS_EA_AF,WFS1
615978,4:6303406:G>A,NM_006005.3:c.1884G>A,NP_005996.2:p.Thr628=,8/8,\N,Unknown significance,\N,synonymous_variant,8.497,0.002,1KG_SAS_AF,WFS1
615979,4:6303406:G>T,NM_006005.3:c.1884G>T,NP_005996.2:p.Thr628=,8/8,\N,Unknown significance,\N,synonymous_variant,3.492,\N,\N,WFS1
615980,4:6303407:C>T,NM_006005.3:c.1885C>T,NP_005996.2:p.Arg629Trp,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.2,0.0014,1KG_AMR_AF,WFS1
615981,4:6303408:G>A,NM_006005.3:c.1886G>A,NP_005996.2:p.Arg629Gln,8/8,\N,Likely pathogenic,WFS1-Related Disorders; Deafness| autosomal dominant 6/14/38,missense_variant,20.6,0.001,1KG_EAS_AF,WFS1
615982,4:6303415:C>T,NM_006005.3:c.1893C>T,NP_005996.2:p.Ser631=,8/8,\N,Unknown significance,\N,synonymous_variant,7.82,0.000453583,EXAC_FIN_AF,WFS1
615983,4:6303421:C>T,NM_006005.3:c.1899C>T,NP_005996.2:p.Val633=,8/8,\N,Unknown significance,\N,synonymous_variant,8.218,0.000226963,EVS_AA_AF,WFS1
615984,4:6303422:A>C,NM_006005.3:c.1900A>C,NP_005996.2:p.Lys634Gln,8/8,\N,Unknown significance,\N,missense_variant,23.3,0.000226963,EVS_AA_AF,WFS1
615985,4:6303423:A>C,NM_006005.3:c.1901A>C,NP_005996.2:p.Lys634Thr,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,23.4,\N,\N,WFS1
615986,4:6303423:A>G,NM_006005.3:c.1901A>G,NP_005996.2:p.Lys634Arg,8/8,\N,Unknown significance,\N,missense_variant,23.7,0.000115607,EXAC_EAS_AF,WFS1
615987,4:6303424:G>T,NM_006005.3:c.1902G>T,NP_005996.2:p.Lys634Asn,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.000115607,EXAC_EAS_AF,WFS1
615988,4:6303425:C>G,NM_006005.3:c.1903C>G,NP_005996.2:p.Leu635Val,8/8,\N,Unknown significance,\N,missense_variant,23.1,0.00030281,EXAC_SAS_AF,WFS1
615989,4:6303430:C>G,NM_006005.3:c.1908C>G,NP_005996.2:p.Ile636Met,8/8,\N,Unknown significance,\N,missense_variant,24.1,0.000060562,EXAC_SAS_AF,WFS1
615990,4:6303430:C>T,NM_006005.3:c.1908C>T,NP_005996.2:p.Ile636=,8/8,\N,Unknown significance,\N,synonymous_variant,10.01,0.0000449748,EXAC_NFE_AF,WFS1
615991,4:6303437:T>G,NM_006005.3:c.1915T>G,NP_005996.2:p.Trp639Gly,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23.2,\N,\N,WFS1
615992,4:6303439:GCTCACGGCCAT>G,NM_006005.3:c.1919_1929del,NP_005996.2:p.Leu640ArgfsTer68,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
615993,4:6303440:C>G,NM_006005.3:c.1918C>G,NP_005996.2:p.Leu640Val,8/8,\N,Likely benign,\N,missense_variant,3.426,\N,\N,WFS1
615994,4:6303442:C>G,NM_006005.3:c.1920C>G,NP_005996.2:p.Leu640=,8/8,\N,Unknown significance,\N,synonymous_variant,1.515,0.000014993,EXAC_NFE_AF,WFS1
615995,4:6303443:A>C,NM_006005.3:c.1921A>C,NP_005996.2:p.Thr641Pro,8/8,\N,Likely benign,\N,missense_variant,9.771,0.0000864006,EXAC_AMR_AF,WFS1
615996,4:6303444:C>A,NM_006005.3:c.1922C>A,NP_005996.2:p.Thr641Lys,8/8,\N,Unknown significance,\N,missense_variant,25,\N,\N,WFS1
615997,4:6303444:C>T,NM_006005.3:c.1922C>T,NP_005996.2:p.Thr641Met,8/8,\N,Unknown significance,\N,missense_variant,27,0.000481788,EXAC_AFR_AF,WFS1
615998,4:6303445:G>A,NM_006005.3:c.1923G>A,NP_005996.2:p.Thr641=,8/8,\N,Unknown significance,\N,synonymous_variant,9.424,0.0008,1KG_AFR_AF,WFS1
615999,4:6303448:C>T,NM_006005.3:c.1926C>T,NP_005996.2:p.Ala642=,8/8,\N,Unknown significance,\N,synonymous_variant,9.848,0.0000864006,EXAC_AMR_AF,WFS1
616000,4:6303451:C>G,NM_006005.3:c.1929C>G,NP_005996.2:p.Ile643Met,8/8,\N,Unknown significance,\N,missense_variant,18.41,0.001,1KG_SAS_AF,WFS1
616001,4:6303451:C>T,NM_006005.3:c.1929C>T,NP_005996.2:p.Ile643=,8/8,\N,Unknown significance,\N,synonymous_variant,11.34,0.000231214,EXAC_EAS_AF,WFS1
616002,4:6303452:G>T,NM_006005.3:c.1930G>T,NP_005996.2:p.Val644Leu,8/8,\N,Likely benign,\N,missense_variant,13.93,0.0000149961,EXAC_NFE_AF,WFS1
616003,4:6303452:G>A,NM_006005.3:c.1930G>A,NP_005996.2:p.Val644Met,8/8,\N,Likely benign,\N,missense_variant,15.43,0.000226963,EVS_AA_AF,WFS1
616004,4:6303452:GTGCTGTTC>G,NM_006005.3:c.1936_1943del,NP_005996.2:p.Phe646ValfsTer63,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
616005,4:6303457:G>T,NM_006005.3:c.1935G>T,NP_005996.2:p.Leu645=,8/8,\N,Likely benign,\N,synonymous_variant,0.482,\N,\N,WFS1
616006,4:6303463:C>A,NM_006005.3:c.1941C>A,NP_005996.2:p.Cys647Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,38,\N,\N,WFS1
616007,4:6303464:T>C,NM_006005.3:c.1942T>C,NP_005996.2:p.Trp648Arg,8/8,\N,Unknown significance,\N,missense_variant,23.4,0.0000149975,EXAC_NFE_AF,WFS1
616008,4:6303465:G>T,NM_006005.3:c.1943G>T,NP_005996.2:p.Trp648Leu,8/8,\N,Unknown significance,\N,missense_variant,23.4,0.0000149975,EXAC_NFE_AF,WFS1
616009,4:6303465:G>A,NM_006005.3:c.1943G>A,NP_005996.2:p.Trp648Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,40,0.0000299949,EXAC_NFE_AF,WFS1
616010,4:6303466:G>A,NM_006005.3:c.1944G>A,NP_005996.2:p.Trp648Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,39,\N,\N,WFS1
616011,4:6303466:G>C,NM_006005.3:c.1944G>C,NP_005996.2:p.Trp648Cys,8/8,\N,Unknown significance,\N,missense_variant,24.6,0.001,1KG_SAS_AF,WFS1
616012,4:6303469:CTA>C,NM_006005.3:c.1949_1950del,NP_005996.2:p.Tyr650CysfsTer61,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
616013,4:6303470:T>G,NM_006005.3:c.1948T>G,NP_005996.2:p.Tyr650Asp,8/8,\N,Unknown significance,\N,missense_variant,26.1,0.000121124,EXAC_SAS_AF,WFS1
616014,4:6303471:A>G,NM_006005.3:c.1949A>G,NP_005996.2:p.Tyr650Cys,8/8,\N,Unknown significance,\N,missense_variant,25.6,0.0000962835,EXAC_AFR_AF,WFS1
616015,4:6303478:C>T,NM_006005.3:c.1956C>T,NP_005996.2:p.Tyr652=,8/8,\N,Unknown significance,\N,synonymous_variant,4.211,0.0000149997,EXAC_NFE_AF,WFS1
616016,4:6303478:C>A,NM_006005.3:c.1956C>A,NP_005996.2:p.Tyr652Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,38,\N,\N,WFS1
616017,4:6303479:C>T,NM_006005.3:c.1957C>T,NP_005996.2:p.Arg653Cys,8/8,\N,Benign,\N,missense_variant,33,0.005,OTO_AJ_AF,WFS1
616018,4:6303479:C>G,NM_006005.3:c.1957C>G,NP_005996.2:p.Arg653Gly,8/8,\N,Unknown significance,\N,missense_variant,28.3,\N,\N,WFS1
616019,4:6303480:G>A,NM_006005.3:c.1958G>A,NP_005996.2:p.Arg653His,8/8,\N,Unknown significance,\N,missense_variant,25.1,0.0000864006,EXAC_AMR_AF,WFS1
616020,4:6303485:G>A,NM_006005.3:c.1963G>A,NP_005996.2:p.Glu655Lys,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,29.3,\N,\N,WFS1
616021,4:6303486:A>G,NM_006005.3:c.1964A>G,NP_005996.2:p.Glu655Gly,8/8,\N,Unknown significance,\N,missense_variant,26.9,\N,\N,WFS1
616022,4:6303488:G>A,NM_006005.3:c.1966G>A,NP_005996.2:p.Gly656Ser,8/8,\N,Unknown significance,\N,missense_variant,24.4,0.0000864006,EXAC_AMR_AF,WFS1
616023,4:6303490:C>T,NM_006005.3:c.1968C>T,NP_005996.2:p.Gly656=,8/8,\N,Unknown significance,\N,synonymous_variant,9.648,0.0014,1KG_AMR_AF,WFS1
616024,4:6303491:A>G,NM_006005.3:c.1969A>G,NP_005996.2:p.Met657Val,8/8,\N,Likely benign,\N,missense_variant,6.38,0.000121124,EXAC_SAS_AF,WFS1
616025,4:6303491:A>T,NM_006005.3:c.1969A>T,NP_005996.2:p.Met657Leu,8/8,\N,Unknown significance,\N,missense_variant,8.078,0.000346901,EXAC_EAS_AF,WFS1
616026,4:6303492:T>C,NM_006005.3:c.1970T>C,NP_005996.2:p.Met657Thr,8/8,\N,Unknown significance,\N,missense_variant,11.58,0.0000150042,EXAC_NFE_AF,WFS1
616027,4:6303493:G>A,NM_006005.3:c.1971G>A,NP_005996.2:p.Met657Ile,8/8,\N,Unknown significance,\N,missense_variant,14.76,0.0000150056,EXAC_NFE_AF,WFS1
616028,4:6303493:GA>G,NM_006005.3:c.1973del,NP_005996.2:p.Lys658ArgfsTer7,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,34,\N,\N,WFS1
616029,4:6303499:C>A,NM_006005.3:c.1977C>A,NP_005996.2:p.Val659=,8/8,\N,Unknown significance,\N,synonymous_variant,10.39,\N,\N,WFS1
616030,4:6303502:C>T,NM_006005.3:c.1980C>T,NP_005996.2:p.Tyr660=,8/8,\N,Unknown significance,\N,synonymous_variant,1.714,0.00277778,OTO_ES_AF,WFS1
616031,4:6303502:C>G,NM_006005.3:c.1980C>G,NP_005996.2:p.Tyr660Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,39,\N,\N,WFS1
616032,4:6303506:T>C,NM_006005.3:c.1984T>C,NP_005996.2:p.Ser662Pro,8/8,\N,Unknown significance,\N,missense_variant,25.9,0.000453926,EVS_AA_AF,WFS1
616033,4:6303507:C>T,NM_006005.3:c.1985C>T,NP_005996.2:p.Ser662Phe,8/8,\N,Unknown significance,\N,missense_variant,28.1,0.0000150128,EXAC_NFE_AF,WFS1
616034,4:6303513:T>G,NM_006005.3:c.1991T>G,NP_005996.2:p.Leu664Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,26.6,\N,\N,WFS1
616035,4:6303515:A>C,NM_006005.3:c.1993A>C,NP_005996.2:p.Thr665Pro,8/8,\N,Unknown significance,\N,missense_variant,24.5,0.00110375,EXAC_OTH_AF,WFS1
616036,4:6303516:C>A,NM_006005.3:c.1994C>A,NP_005996.2:p.Thr665Asn,8/8,\N,Unknown significance,\N,missense_variant,24,\N,\N,WFS1
616037,4:6303516:C>G,NM_006005.3:c.1994C>G,NP_005996.2:p.Thr665Ser,8/8,\N,Likely benign,\N,missense_variant,11.29,0.000060562,EXAC_SAS_AF,WFS1
616038,4:6303516:C>T,NM_006005.3:c.1994C>T,NP_005996.2:p.Thr665Ile,8/8,\N,Unknown significance,\N,missense_variant,25,0.000226963,EVS_AA_AF,WFS1
616039,4:6303519:G>A,NM_006005.3:c.1997G>A,NP_005996.2:p.Trp666Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,39,\N,\N,WFS1
616040,4:6303521:C>T,NM_006005.3:c.1999C>T,NP_005996.2:p.Gln667Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,38,0.000463177,EXAC_EAS_AF,WFS1
616041,4:6303522:A>G,NM_006005.3:c.2000A>G,NP_005996.2:p.Gln667Arg,8/8,\N,Likely benign,\N,missense_variant,0.022,0.0000150218,EXAC_NFE_AF,WFS1
616042,4:6303523:G>A,NM_006005.3:c.2001G>A,NP_005996.2:p.Gln667=,8/8,\N,Unknown significance,\N,synonymous_variant,0.017,0.000121124,EXAC_SAS_AF,WFS1
616043,4:6303524:C>T,NM_006005.3:c.2002C>T,NP_005996.2:p.Gln668Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,38,\N,\N,WFS1
616044,4:6303524:C>A,NM_006005.3:c.2002C>A,NP_005996.2:p.Gln668Lys,8/8,\N,Unknown significance,\N,missense_variant,25,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616045,4:6303527:T>C,NM_006005.3:c.2005T>C,NP_005996.2:p.Tyr669His,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,24,\N,\N,WFS1
616046,4:6303528:A>G,NM_006005.3:c.2006A>G,NP_005996.2:p.Tyr669Cys,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.1,\N,\N,WFS1
616047,4:6303529:T>G,NM_006005.3:c.2007T>G,NP_005996.2:p.Tyr669Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,35,\N,\N,WFS1
616048,4:6303531:G>A,NM_006005.3:c.2009G>A,NP_005996.2:p.Gly670Asp,8/8,\N,Unknown significance,\N,missense_variant,5.843,0.0000150299,EXAC_NFE_AF,WFS1
616049,4:6303531:G>GT,NM_006005.3:c.2010dup,NP_005996.2:p.Ala671CysfsTer41,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,27.1,\N,\N,WFS1
616050,4:6303533:G>T,NM_006005.3:c.2011G>T,NP_005996.2:p.Ala671Ser,8/8,\N,Likely benign,\N,missense_variant,0.001,0.000060562,EXAC_SAS_AF,WFS1
616051,4:6303534:C>T,NM_006005.3:c.2012C>T,NP_005996.2:p.Ala671Val,8/8,\N,Benign,\N,missense_variant,0.015,0.0603,1KG_SAS_AF,WFS1
616052,4:6303535:G>A,NM_006005.3:c.2013G>A,NP_005996.2:p.Ala671=,8/8,\N,Likely benign,\N,synonymous_variant,0.126,0.001,1KG_EUR_AF,WFS1
616053,4:6303536:C>T,NM_006005.3:c.2014C>T,NP_005996.2:p.Leu672=,8/8,\N,Unknown significance,\N,synonymous_variant,0.437,0.000116279,EVS_EA_AF,WFS1
616054,4:6303537:T>C,NM_006005.3:c.2015T>C,NP_005996.2:p.Leu672Pro,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23.6,\N,\N,WFS1
616055,4:6303541:C>T,NM_006005.3:c.2019C>T,NP_005996.2:p.Cys673=,8/8,\N,Benign,\N,synonymous_variant,4.274,0.0546981,EVS_AA_AF,WFS1
616056,4:6303542:G>A,NM_006005.3:c.2020G>A,NP_005996.2:p.Gly674Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.4,0.00136075,EXAC_FIN_AF,WFS1
616057,4:6303542:G>C,NM_006005.3:c.2020G>C,NP_005996.2:p.Gly674Arg,8/8,\N,Unknown significance,\N,missense_variant,24.1,0.000060562,EXAC_SAS_AF,WFS1
616058,4:6303543:G>A,NM_006005.3:c.2021G>A,NP_005996.2:p.Gly674Glu,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,23.3,\N,\N,WFS1
616059,4:6303543:G>T,NM_006005.3:c.2021G>T,NP_005996.2:p.Gly674Val,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,24.7,\N,\N,WFS1
616060,4:6303548:C>G,NM_006005.3:c.2026C>G,NP_005996.2:p.Arg676Gly,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.000060562,EXAC_SAS_AF,WFS1
616061,4:6303548:C>T,NM_006005.3:c.2026C>T,NP_005996.2:p.Arg676Cys,8/8,\N,Unknown significance,\N,missense_variant,27.7,0.000232558,EVS_EA_AF,WFS1
616062,4:6303549:G>A,NM_006005.3:c.2027G>A,NP_005996.2:p.Arg676His,8/8,\N,Unknown significance,\N,missense_variant,23.9,0.001,1KG_EUR_AF,WFS1
616063,4:6303549:G>C,NM_006005.3:c.2027G>C,NP_005996.2:p.Arg676Pro,8/8,\N,Unknown significance,\N,missense_variant,23,0.000116279,EVS_EA_AF,WFS1
616064,4:6303550:C>T,NM_006005.3:c.2028C>T,NP_005996.2:p.Arg676=,8/8,\N,Unknown significance,\N,synonymous_variant,8.939,0.0015,1KG_AFR_AF,WFS1
616065,4:6303551:G>A,NM_006005.3:c.2029G>A,NP_005996.2:p.Ala677Thr,8/8,\N,Unknown significance,\N,missense_variant,23.5,0.000115929,EXAC_EAS_AF,WFS1
616066,4:6303555:G>T,NM_006005.3:c.2033G>T,NP_005996.2:p.Trp678Leu,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,27.6,\N,\N,WFS1
616067,4:6303557:A>C,NM_006005.3:c.2035A>C,NP_005996.2:p.Lys679Gln,8/8,\N,Unknown significance,\N,missense_variant,13.15,0.000386026,EXAC_AFR_AF,WFS1
616068,4:6303557:AAGG>A,NM_006005.3:c.2038_2040del,NP_005996.2:p.Glu680del,8/8,\N,Pathogenic,Hearing loss,inframe_deletion,\N,\N,\N,WFS1
616069,4:6303561:A>C,NM_006005.3:c.2039A>C,NP_005996.2:p.Glu680Ala,8/8,\N,Unknown significance,\N,missense_variant,23.3,0.0045,1KG_AFR_AF,WFS1
616070,4:6303562:G>A,NM_006005.3:c.2040G>A,NP_005996.2:p.Glu680=,8/8,\N,Benign,\N,synonymous_variant,4.086,0.00372037,EXAC_AMR_AF,WFS1
616071,4:6303565:C>T,NM_006005.3:c.2043C>T,NP_005996.2:p.Thr681=,8/8,\N,Unknown significance,\N,synonymous_variant,7.462,\N,\N,WFS1
616072,4:6303569:A>G,NM_006005.3:c.2047A>G,NP_005996.2:p.Met683Val,8/8,\N,Unknown significance,\N,missense_variant,11.94,\N,\N,WFS1
616073,4:6303570:T>G,NM_006005.3:c.2048T>G,NP_005996.2:p.Met683Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23.9,\N,\N,WFS1
616074,4:6303571:G>A,NM_006005.3:c.2049G>A,NP_005996.2:p.Met683Ile,8/8,\N,Unknown significance,\N,missense_variant,17.95,\N,\N,WFS1
616075,4:6303572:G>A,NM_006005.3:c.2050G>A,NP_005996.2:p.Ala684Thr,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,28,\N,\N,WFS1
616076,4:6303573:C>T,NM_006005.3:c.2051C>T,NP_005996.2:p.Ala684Val,8/8,\N,Pathogenic,DFNA6/14/38 and optic atrophy,missense_variant,32,\N,\N,WFS1
616077,4:6303573:C>G,NM_006005.3:c.2051C>G,NP_005996.2:p.Ala684Gly,8/8,\N,Likely pathogenic,Wolfram syndrome,missense_variant,28.7,\N,\N,WFS1
616078,4:6303574:G>A,NM_006005.3:c.2052G>A,NP_005996.2:p.Ala684=,8/8,\N,Benign,\N,synonymous_variant,1.701,0.0058,1KG_AMR_AF,WFS1
616079,4:6303575:C>T,NM_006005.3:c.2053C>T,NP_005996.2:p.Arg685Cys,8/8,\N,Unknown significance,\N,missense_variant,34,0.0025,OTO_JP_AF,WFS1
616080,4:6303576:G>A,NM_006005.3:c.2054G>A,NP_005996.2:p.Arg685His,8/8,\N,Unknown significance,\N,missense_variant,24.7,0.000232558,EVS_EA_AF,WFS1
616081,4:6303576:G>C,NM_006005.3:c.2054G>C,NP_005996.2:p.Arg685Pro,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,24.7,\N,\N,WFS1
616082,4:6303579:C>A,NM_006005.3:c.2057C>A,NP_005996.2:p.Thr686Asn,8/8,\N,Unknown significance,\N,missense_variant,26.2,0.0000151199,EXAC_NFE_AF,WFS1
616083,4:6303579:C>T,NM_006005.3:c.2057C>T,NP_005996.2:p.Thr686Ile,8/8,\N,Unknown significance,\N,missense_variant,24.2,0.0000302398,EXAC_NFE_AF,WFS1
616084,4:6303581:C>T,NM_006005.3:c.2059C>T,NP_005996.2:p.Gln687Ter,8/8,\N,Unknown significance,\N,stop_gained,41,0.0000151258,EXAC_NFE_AF,WFS1
616085,4:6303583:G>C,NM_006005.3:c.2061G>C,NP_005996.2:p.Gln687His,8/8,\N,Unknown significance,\N,missense_variant,26.2,0.0000866251,EXAC_AMR_AF,WFS1
616086,4:6303587:C>G,NM_006005.3:c.2065C>G,NP_005996.2:p.Leu689Val,8/8,\N,Unknown significance,\N,missense_variant,11.64,0.0000866701,EXAC_AMR_AF,WFS1
616087,4:6303590:T>C,NM_006005.3:c.2068T>C,NP_005996.2:p.Cys690Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.1,0.0000303131,EXAC_NFE_AF,WFS1
616088,4:6303590:T>G,NM_006005.3:c.2068T>G,NP_005996.2:p.Cys690Gly,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.8,\N,\N,WFS1
616089,4:6303597:A>C,NM_006005.3:c.2075A>C,NP_005996.2:p.His692Pro,8/8,\N,Unknown significance,\N,missense_variant,25.2,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616090,4:6303601:G>A,NM_006005.3:c.2079G>A,NP_005996.2:p.Leu693=,8/8,\N,Unknown significance,\N,synonymous_variant,3.427,0.0000151883,EXAC_NFE_AF,WFS1
616091,4:6303602:G>C,NM_006005.3:c.2080G>C,NP_005996.2:p.Glu694Gln,8/8,\N,Unknown significance,\N,missense_variant,14.88,\N,\N,WFS1
616092,4:6303602:G>T,NM_006005.3:c.2080G>T,NP_005996.2:p.Glu694Ter,8/8,\N,Unknown significance,\N,stop_gained,42,0.0000151888,EXAC_NFE_AF,WFS1
616093,4:6303604:G>C,NM_006005.3:c.2082G>C,NP_005996.2:p.Glu694Asp,8/8,\N,Unknown significance,\N,missense_variant,14.6,0.0000151953,EXAC_NFE_AF,WFS1
616094,4:6303606:G>T,NM_006005.3:c.2084G>T,NP_005996.2:p.Gly695Val,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,26.9,\N,\N,WFS1
616095,4:6303606:G>A,NM_006005.3:c.2084G>A,NP_005996.2:p.Gly695Asp,8/8,\N,Unknown significance,\N,missense_variant,26.7,0.000304971,EXAC_FIN_AF,WFS1
616096,4:6303607:C>T,NM_006005.3:c.2085C>T,NP_005996.2:p.Gly695=,8/8,\N,Unknown significance,\N,synonymous_variant,9.686,0.00204267,EVS_AA_AF,WFS1
616097,4:6303608:C>T,NM_006005.3:c.2086C>T,NP_005996.2:p.His696Tyr,8/8,\N,Pathogenic,Sensorineural hearing loss| nonsyndromic,missense_variant,22.8,\N,\N,WFS1
616098,4:6303613:G>C,NM_006005.3:c.2091G>C,NP_005996.2:p.Arg697Ser,8/8,\N,Unknown significance,\N,missense_variant,23.1,0.0008,1KG_AFR_AF,WFS1
616099,4:6303616:C>A,NM_006005.3:c.2094C>A,NP_005996.2:p.Val698=,8/8,\N,Unknown significance,\N,synonymous_variant,11.68,0.001,1KG_EUR_AF,WFS1
616100,4:6303618:C>T,NM_006005.3:c.2096C>T,NP_005996.2:p.Thr699Met,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,32,\N,\N,WFS1
616101,4:6303619:G>A,NM_006005.3:c.2097G>A,NP_005996.2:p.Thr699=,8/8,\N,Unknown significance,\N,synonymous_variant,10.46,0.0000606649,EXAC_SAS_AF,WFS1
616102,4:6303621:G>A,NM_006005.3:c.2099G>A,NP_005996.2:p.Trp700Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,42,0.000116279,EVS_EA_AF,WFS1
616103,4:6303622:G>T,NM_006005.3:c.2100G>T,NP_005996.2:p.Trp700Cys,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,27.1,\N,\N,WFS1
616104,4:6303623:A>C,NM_006005.3:c.2101A>C,NP_005996.2:p.Thr701Pro,8/8,\N,Unknown significance,\N,missense_variant,23,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616105,4:6303624:C>G,NM_006005.3:c.2102C>G,NP_005996.2:p.Thr701Ser,8/8,\N,Unknown significance,\N,missense_variant,16.86,\N,\N,WFS1
616106,4:6303624:C>T,NM_006005.3:c.2102C>T,NP_005996.2:p.Thr701Ile,8/8,\N,Unknown significance,\N,missense_variant,25.8,\N,\N,WFS1
616107,4:6303625:C>T,NM_006005.3:c.2103C>T,NP_005996.2:p.Thr701=,8/8,\N,Likely benign,\N,synonymous_variant,9.568,0.000107102,EXAC_NFE_AF,WFS1
616108,4:6303625:C>G,NM_006005.3:c.2103C>G,NP_005996.2:p.Thr701=,8/8,\N,Unknown significance,\N,synonymous_variant,6.325,\N,\N,WFS1
616109,4:6303626:G>A,NM_006005.3:c.2104G>A,NP_005996.2:p.Gly702Ser,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,29.2,0.000182083,EXAC_SAS_AF,WFS1
616110,4:6303627:G>A,NM_006005.3:c.2105G>A,NP_005996.2:p.Gly702Asp,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.6,\N,\N,WFS1
616111,4:6303629:C>T,NM_006005.3:c.2107C>T,NP_005996.2:p.Arg703Cys,8/8,\N,Unknown significance,\N,missense_variant,32,0.000121389,EXAC_SAS_AF,WFS1
616112,4:6303630:G>A,NM_006005.3:c.2108G>A,NP_005996.2:p.Arg703His,8/8,\N,Pathogenic,Sensorineural hearing loss| nonsyndromic,missense_variant,25,\N,\N,WFS1
616113,4:6303631:C>T,NM_006005.3:c.2109C>T,NP_005996.2:p.Arg703=,8/8,\N,Unknown significance,\N,synonymous_variant,4.681,0.0000607091,EXAC_SAS_AF,WFS1
616114,4:6303637:G>C,NM_006005.3:c.2115G>C,NP_005996.2:p.Lys705Asn,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,20.9,\N,\N,WFS1
616115,4:6303640:C>T,NM_006005.3:c.2118C>T,NP_005996.2:p.Tyr706=,8/8,\N,Unknown significance,\N,synonymous_variant,2.53,0.000232612,EVS_EA_AF,WFS1
616116,4:6303641:G>A,NM_006005.3:c.2119G>A,NP_005996.2:p.Val707Ile,8/8,\N,Unknown significance,\N,missense_variant,23,0.000453926,EVS_AA_AF,WFS1
616117,4:6303641:G>T,NM_006005.3:c.2119G>T,NP_005996.2:p.Val707Phe,8/8,\N,Pathogenic,Diabetes mellitus AND insipidus with optic atrophy AND deafness; WOLFRAM SYNDROME 1,missense_variant,25.5,\N,\N,WFS1
616118,4:6303644:C>T,NM_006005.3:c.2122C>T,NP_005996.2:p.Arg708Cys,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,27.5,0.000234302,EXAC_EAS_AF,WFS1
616119,4:6303645:G>A,NM_006005.3:c.2123G>A,NP_005996.2:p.Arg708His,8/8,\N,Unknown significance,\N,missense_variant,25.9,0.000117069,EXAC_EAS_AF,WFS1
616120,4:6303646:C>T,NM_006005.3:c.2124C>T,NP_005996.2:p.Arg708=,8/8,\N,Benign,\N,synonymous_variant,6.119,0.015,OTO_TR_AF,WFS1
616121,4:6303647:G>A,NM_006005.3:c.2125G>A,NP_005996.2:p.Val709Met,8/8,\N,Unknown significance,\N,missense_variant,24.5,0.000182571,EXAC_SAS_AF,WFS1
616122,4:6303649:G>C,NM_006005.3:c.2127G>C,NP_005996.2:p.Val709=,8/8,\N,Unknown significance,\N,synonymous_variant,0.008,0.0008,1KG_AFR_AF,WFS1
616123,4:6303651:C>G,NM_006005.3:c.2129C>G,NP_005996.2:p.Thr710Ser,8/8,\N,Unknown significance,\N,missense_variant,19.14,0.0014,1KG_AMR_AF,WFS1
616124,4:6303653:G>A,NM_006005.3:c.2131G>A,NP_005996.2:p.Asp711Asn,8/8,\N,Unknown significance,\N,missense_variant,20.4,0.0010357,EXAC_SAS_AF,WFS1
616125,4:6303656:A>G,NM_006005.3:c.2134A>G,NP_005996.2:p.Ile712Val,8/8,\N,Unknown significance,\N,missense_variant,8.578,0.0014,1KG_AMR_AF,WFS1
616126,4:6303658:C>A,NM_006005.3:c.2136C>A,NP_005996.2:p.Ile712=,8/8,\N,Unknown significance,\N,synonymous_variant,14.11,0.0000155058,EXAC_NFE_AF,WFS1
616127,4:6303658:C>T,NM_006005.3:c.2136C>T,NP_005996.2:p.Ile712=,8/8,\N,Unknown significance,\N,synonymous_variant,11.02,0.0000610128,EXAC_SAS_AF,WFS1
616128,4:6303659:GACAACAGCGCCGAGTCTGCCATCA>G,NM_006005.3:c.2141_2164del,NP_005996.2:p.Asn714_Asn721del,8/8,\N,Unknown significance,\N,inframe_deletion,17.81,\N,\N,WFS1
616129,4:6303660:A>G,NM_006005.3:c.2138A>G,NP_005996.2:p.Asp713Gly,8/8,\N,Unknown significance,\N,missense_variant,24.8,0.001,1KG_EUR_AF,WFS1
616130,4:6303663:A>C,NM_006005.3:c.2141A>C,NP_005996.2:p.Asn714Thr,8/8,\N,Pathogenic,WFS1-Related Disorders; Deafness| autosomal dominant 6/14/38,missense_variant,24.3,\N,\N,WFS1
616131,4:6303665:A>G,NM_006005.3:c.2143A>G,NP_005996.2:p.Ser715Gly,8/8,\N,Unknown significance,\N,missense_variant,13.99,0.000352361,EXAC_EAS_AF,WFS1
616132,4:6303666:G>T,NM_006005.3:c.2144G>T,NP_005996.2:p.Ser715Ile,8/8,\N,Unknown significance,\N,missense_variant,25,0.000234907,EXAC_EAS_AF,WFS1
616133,4:6303667:C>G,NM_006005.3:c.2145C>G,NP_005996.2:p.Ser715Arg,8/8,\N,Unknown significance,\N,missense_variant,22.7,0.0000155531,EXAC_NFE_AF,WFS1
616134,4:6303667:C>T,NM_006005.3:c.2145C>T,NP_005996.2:p.Ser715=,8/8,\N,Unknown significance,\N,synonymous_variant,10.6,0.000101071,EXAC_AFR_AF,WFS1
616135,4:6303668:G>A,NM_006005.3:c.2146G>A,NP_005996.2:p.Ala716Thr,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,23.5,0.0000155681,EXAC_NFE_AF,WFS1
616136,4:6303670:C>T,NM_006005.3:c.2148C>T,NP_005996.2:p.Ala716=,8/8,\N,Unknown significance,\N,synonymous_variant,9.78,0.000305736,EXAC_SAS_AF,WFS1
616137,4:6303671:G>A,NM_006005.3:c.2149G>A,NP_005996.2:p.Glu717Lys,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.7,0.000117702,EXAC_EAS_AF,WFS1
616138,4:6303673:G>A,NM_006005.3:c.2151G>A,NP_005996.2:p.Glu717=,8/8,\N,Unknown significance,\N,synonymous_variant,1.239,0.0000155681,EXAC_NFE_AF,WFS1
616139,4:6303676:T>C,NM_006005.3:c.2154T>C,NP_005996.2:p.Ser718=,8/8,\N,Unknown significance,\N,synonymous_variant,0.024,0.0000467392,EXAC_NFE_AF,WFS1
616140,4:6303678:C>T,NM_006005.3:c.2156C>T,NP_005996.2:p.Ala719Val,8/8,\N,Unknown significance,\N,missense_variant,22.8,0.0000311993,EXAC_NFE_AF,WFS1
616141,4:6303679:C>G,NM_006005.3:c.2157C>G,NP_005996.2:p.Ala719=,8/8,\N,Unknown significance,\N,synonymous_variant,5.996,0.000061192,EXAC_SAS_AF,WFS1
616142,4:6303680:A>G,NM_006005.3:c.2158A>G,NP_005996.2:p.Ile720Val,8/8,\N,Benign,\N,missense_variant,8.367,0.075,OTO_JP_AF,WFS1
616143,4:6303680:A>C,NM_006005.3:c.2158A>C,NP_005996.2:p.Ile720Leu,8/8,\N,Unknown significance,\N,missense_variant,11.86,0.000779788,EXAC_FIN_AF,WFS1
616144,4:6303682:C>T,NM_006005.3:c.2160C>T,NP_005996.2:p.Ile720=,8/8,\N,Unknown significance,\N,synonymous_variant,8.131,0.000087858,EXAC_AMR_AF,WFS1
616145,4:6303684:A>G,NM_006005.3:c.2162A>G,NP_005996.2:p.Asn721Ser,8/8,\N,Unknown significance,\N,missense_variant,19.96,0.000312305,EXAC_FIN_AF,WFS1
616146,4:6303684:A>T,NM_006005.3:c.2162A>T,NP_005996.2:p.Asn721Ile,8/8,\N,Unknown significance,\N,missense_variant,25.1,0.0000612745,EXAC_SAS_AF,WFS1
616147,4:6303686:A>G,NM_006005.3:c.2164A>G,NP_005996.2:p.Met722Val,8/8,\N,Likely benign,\N,missense_variant,8.118,0.00011773,EXAC_EAS_AF,WFS1
616148,4:6303686:A>C,NM_006005.3:c.2164A>C,NP_005996.2:p.Met722Leu,8/8,\N,Unknown significance,\N,missense_variant,4.854,0.000102145,EXAC_AFR_AF,WFS1
616149,4:6303688:G>A,NM_006005.3:c.2166G>A,NP_005996.2:p.Met722Ile,8/8,\N,Unknown significance,\N,missense_variant,19.5,0.000117841,EXAC_EAS_AF,WFS1
616150,4:6303690:T>C,NM_006005.3:c.2168T>C,NP_005996.2:p.Leu723Pro,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.5,\N,\N,WFS1
616151,4:6303692:C>T,NM_006005.3:c.2170C>T,NP_005996.2:p.Pro724Ser,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.3,0.000117841,EXAC_EAS_AF,WFS1
616152,4:6303693:C>T,NM_006005.3:c.2171C>T,NP_005996.2:p.Pro724Leu,8/8,\N,Unknown significance,\N,missense_variant,31,0.005,OTO_JP_AF,WFS1
616153,4:6303694:G>T,NM_006005.3:c.2172G>T,NP_005996.2:p.Pro724=,8/8,\N,Unknown significance,\N,synonymous_variant,4.734,0.000226963,EVS_AA_AF,WFS1
616154,4:6303695:T>TTCTTC,NM_006005.3:c.2174_2178dup,NP_005996.2:p.Ile727SerfsTer137,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,26.6,\N,\N,WFS1
616155,4:6303697:C>G,NM_006005.3:c.2175C>G,NP_005996.2:p.Phe725Leu,8/8,\N,Likely benign,\N,missense_variant,10.25,0.000226963,EVS_AA_AF,WFS1
616156,4:6303703:C>T,NM_006005.3:c.2181C>T,NP_005996.2:p.Ile727=,8/8,\N,Unknown significance,\N,synonymous_variant,10.86,0.00116279,EXAC_OTH_AF,WFS1
616157,4:6303704:G>A,NM_006005.3:c.2182G>A,NP_005996.2:p.Gly728Ser,8/8,\N,Unknown significance,\N,missense_variant,24.1,0.001,1KG_EAS_AF,WFS1
616158,4:6303706:C>T,NM_006005.3:c.2184C>T,NP_005996.2:p.Gly728=,8/8,\N,Benign,\N,synonymous_variant,13.68,0.0603,1KG_SAS_AF,WFS1
616159,4:6303707:G>A,NM_006005.3:c.2185G>A,NP_005996.2:p.Asp729Asn,8/8,\N,Pathogenic,Diabetes| type 1| and sensorineural hearing loss,missense_variant,16.61,0.002,1KG_SAS_AF,WFS1
616160,4:6303709:C>T,NM_006005.3:c.2187C>T,NP_005996.2:p.Asp729=,8/8,\N,Unknown significance,\N,synonymous_variant,7.442,0.000116333,EVS_EA_AF,WFS1
616161,4:6303710:T>G,NM_006005.3:c.2188T>G,NP_005996.2:p.Trp730Gly,8/8,\N,Unknown significance,\N,missense_variant,24,0.000118092,EXAC_EAS_AF,WFS1
616162,4:6303711:G>A,NM_006005.3:c.2189G>A,NP_005996.2:p.Trp730Ter,8/8,\N,Unknown significance,\N,stop_gained,41,0.000176336,EXAC_AMR_AF,WFS1
616163,4:6303712:G>T,NM_006005.3:c.2190G>T,NP_005996.2:p.Trp730Cys,8/8,\N,Unknown significance,\N,missense_variant,25,0.0000882457,EXAC_AMR_AF,WFS1
616164,4:6303712:G>C,NM_006005.3:c.2190G>C,NP_005996.2:p.Trp730Cys,8/8,\N,Benign,\N,missense_variant,24.8,0.00625,OTO_US_AF,WFS1
616165,4:6303713:A>C,NM_006005.3:c.2191A>C,NP_005996.2:p.Met731Leu,8/8,\N,Likely benign,\N,missense_variant,0.058,0.000227169,EVS_AA_AF,WFS1
616166,4:6303713:A>G,NM_006005.3:c.2191A>G,NP_005996.2:p.Met731Val,8/8,\N,Unknown significance,\N,missense_variant,2.283,0.0000159134,EXAC_NFE_AF,WFS1
616167,4:6303714:T>C,NM_006005.3:c.2192T>C,NP_005996.2:p.Met731Thr,8/8,\N,Unknown significance,\N,missense_variant,21.7,0.000227169,EVS_AA_AF,WFS1
616168,4:6303716:C>T,NM_006005.3:c.2194C>T,NP_005996.2:p.Arg732Cys,8/8,\N,Likely pathogenic,\N,missense_variant,32,0.000116469,EVS_EA_AF,WFS1
616169,4:6303717:G>A,NM_006005.3:c.2195G>A,NP_005996.2:p.Arg732His,8/8,\N,Benign*,\N,missense_variant,32,0.0053,1KG_AFR_AF,WFS1
616170,4:6303718:C>A,NM_006005.3:c.2196C>A,NP_005996.2:p.Arg732=,8/8,\N,Unknown significance,\N,synonymous_variant,10.61,\N,\N,WFS1
616171,4:6303720:G>A,NM_006005.3:c.2198G>A,NP_005996.2:p.Cys733Tyr,8/8,\N,Unknown significance,\N,missense_variant,26.1,\N,\N,WFS1
616172,4:6303721:C>T,NM_006005.3:c.2199C>T,NP_005996.2:p.Cys733=,8/8,\N,Unknown significance,\N,synonymous_variant,8.068,0.000227376,EVS_AA_AF,WFS1
616173,4:6303722:C>T,NM_006005.3:c.2200C>T,NP_005996.2:p.Leu734Phe,8/8,\N,Unknown significance,\N,missense_variant,23.7,0.000118343,EXAC_EAS_AF,WFS1
616174,4:6303724:C>T,NM_006005.3:c.2202C>T,NP_005996.2:p.Leu734=,8/8,\N,Likely benign,\N,synonymous_variant,6.489,0.0015,1KG_AFR_AF,WFS1
616175,4:6303727:C>T,NM_006005.3:c.2205C>T,NP_005996.2:p.Tyr735=,8/8,\N,Benign,\N,synonymous_variant,9.544,0.0166,1KG_AFR_AF,WFS1
616176,4:6303727:C>A,NM_006005.3:c.2205C>A,NP_005996.2:p.Tyr735Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,37,\N,\N,WFS1
616177,4:6303728:G>A,NM_006005.3:c.2206G>A,NP_005996.2:p.Gly736Ser,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,32,0.000118483,EXAC_EAS_AF,WFS1
616178,4:6303728:G>C,NM_006005.3:c.2206G>C,NP_005996.2:p.Gly736Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,29.4,\N,\N,WFS1
616179,4:6303729:G>A,NM_006005.3:c.2207G>A,NP_005996.2:p.Gly736Asp,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,26.7,\N,\N,WFS1
616180,4:6303730:C>T,NM_006005.3:c.2208C>T,NP_005996.2:p.Gly736=,8/8,\N,Benign,\N,synonymous_variant,13.67,0.005,OTO_TR_AF,WFS1
616181,4:6303731:G>A,NM_006005.3:c.2209G>A,NP_005996.2:p.Glu737Lys,8/8,\N,Benign*,\N,missense_variant,25.5,0.045,OTO_JP_AF,WFS1
616182,4:6303734:G>A,NM_006005.3:c.2212G>A,NP_005996.2:p.Ala738Thr,8/8,\N,Unknown significance,\N,missense_variant,12.31,0.0000160488,EXAC_NFE_AF,WFS1
616183,4:6303735:C>A,NM_006005.3:c.2213C>A,NP_005996.2:p.Ala738Asp,8/8,\N,Unknown significance,\N,missense_variant,21.9,0.0000481247,EXAC_NFE_AF,WFS1
616184,4:6303737:T>G,NM_006005.3:c.2215T>G,NP_005996.2:p.Tyr739Asp,8/8,\N,Unknown significance,\N,missense_variant,26.2,0.000116795,EVS_EA_AF,WFS1
616185,4:6303738:A>C,NM_006005.3:c.2216A>C,NP_005996.2:p.Tyr739Ser,8/8,\N,Unknown significance,\N,missense_variant,26.5,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616186,4:6303740:C>T,NM_006005.3:c.2218C>T,NP_005996.2:p.Pro740Ser,8/8,\N,Unknown significance,\N,missense_variant,23.9,0.000493279,EXAC_SAS_AF,WFS1
616187,4:6303741:C>A,NM_006005.3:c.2219C>A,NP_005996.2:p.Pro740His,8/8,\N,Unknown significance,\N,missense_variant,23.8,0.0000160092,EXAC_NFE_AF,WFS1
616188,4:6303741:C>T,NM_006005.3:c.2219C>T,NP_005996.2:p.Pro740Leu,8/8,\N,Unknown significance,\N,missense_variant,24,0.0000882613,EXAC_AMR_AF,WFS1
616189,4:6303744:C>T,NM_006005.3:c.2222C>T,NP_005996.2:p.Ala741Val,8/8,\N,Unknown significance,\N,missense_variant,4.682,0.0000883392,EXAC_AMR_AF,WFS1
616190,4:6303744:C>G,NM_006005.3:c.2222C>G,NP_005996.2:p.Ala741Gly,8/8,\N,Likely benign,\N,missense_variant,0.379,0.0000616523,EXAC_SAS_AF,WFS1
616191,4:6303745:C>A,NM_006005.3:c.2223C>A,NP_005996.2:p.Ala741=,8/8,\N,Unknown significance,\N,synonymous_variant,4.418,0.000112036,EXAC_NFE_AF,WFS1
616192,4:6303745:C>T,NM_006005.3:c.2223C>T,NP_005996.2:p.Ala741=,8/8,\N,Unknown significance,\N,synonymous_variant,3.723,0.0000160051,EXAC_NFE_AF,WFS1
616193,4:6303745:C>CT,NM_006005.3:c.2224dup,NP_005996.2:p.Cys742LeufsTer17,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,32,\N,\N,WFS1
616194,4:6303746:T>C,NM_006005.3:c.2224T>C,NP_005996.2:p.Cys742Arg,8/8,\N,Unknown significance,\N,missense_variant,23.6,\N,\N,WFS1
616195,4:6303746:T>G,NM_006005.3:c.2224T>G,NP_005996.2:p.Cys742Gly,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,21.1,\N,\N,WFS1
616196,4:6303747:G>A,NM_006005.3:c.2225G>A,NP_005996.2:p.Cys742Tyr,8/8,\N,Unknown significance,\N,missense_variant,24.1,0.0000320277,EXAC_NFE_AF,WFS1
616197,4:6303748:C>G,NM_006005.3:c.2226C>G,NP_005996.2:p.Cys742Trp,8/8,\N,Unknown significance,\N,missense_variant,23.3,\N,\N,WFS1
616198,4:6303751:C>T,NM_006005.3:c.2229C>T,NP_005996.2:p.Ser743=,8/8,\N,Unknown significance,\N,synonymous_variant,0.132,0.000118287,EXAC_EAS_AF,WFS1
616199,4:6303754:T>G,NM_006005.3:c.2232T>G,NP_005996.2:p.Pro744=,8/8,\N,Unknown significance,\N,synonymous_variant,0.002,0.000116577,EVS_EA_AF,WFS1
616200,4:6303755:G>A,NM_006005.3:c.2233G>A,NP_005996.2:p.Gly745Ser,8/8,\N,Likely benign,\N,missense_variant,0.032,0.003,1KG_AFR_AF,WFS1
616201,4:6303757:C>T,NM_006005.3:c.2235C>T,NP_005996.2:p.Gly745=,8/8,\N,Unknown significance,\N,synonymous_variant,0.281,0.0000616523,EXAC_SAS_AF,WFS1
616202,4:6303761:A>C,NM_006005.3:c.2239A>C,NP_005996.2:p.Thr747Pro,8/8,\N,Benign,\N,missense_variant,0.001,0.009375,OTO_US_AF,WFS1
616203,4:6303768:C>G,NM_006005.3:c.2246C>G,NP_005996.2:p.Thr749Arg,8/8,\N,Likely benign,\N,missense_variant,15.45,0.001,1KG_EAS_AF,WFS1
616204,4:6303768:C>T,NM_006005.3:c.2246C>T,NP_005996.2:p.Thr749Met,8/8,\N,Likely benign,\N,missense_variant,12.46,0.000116768,EVS_EA_AF,WFS1
616205,4:6303769:G>A,NM_006005.3:c.2247G>A,NP_005996.2:p.Thr749=,8/8,\N,Benign,\N,synonymous_variant,1.044,0.0171882,EXAC_AFR_AF,WFS1
616206,4:6303770:G>A,NM_006005.3:c.2248G>A,NP_005996.2:p.Ala750Thr,8/8,\N,Unknown significance,\N,missense_variant,17.64,0.0029,1KG_AMR_AF,WFS1
616207,4:6303772:C>G,NM_006005.3:c.2250C>G,NP_005996.2:p.Ala750=,8/8,\N,Unknown significance,\N,synonymous_variant,3.144,0.000118064,EXAC_EAS_AF,WFS1
616208,4:6303772:C>T,NM_006005.3:c.2250C>T,NP_005996.2:p.Ala750=,8/8,\N,Unknown significance,\N,synonymous_variant,8.881,0.000592474,EXAC_NFE_AF,WFS1
616209,4:6303773:G>A,NM_006005.3:c.2251G>A,NP_005996.2:p.Glu751Lys,8/8,\N,Unknown significance,\N,missense_variant,21,0.0000615385,EXAC_SAS_AF,WFS1
616210,4:6303773:G>C,NM_006005.3:c.2251G>C,NP_005996.2:p.Glu751Gln,8/8,\N,Unknown significance,\N,missense_variant,13.66,0.0008,1KG_AFR_AF,WFS1
616211,4:6303776:G>T,NM_006005.3:c.2254G>T,NP_005996.2:p.Glu752Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,38,0.000116632,EVS_EA_AF,WFS1
616212,4:6303776:G>A,NM_006005.3:c.2254G>A,NP_005996.2:p.Glu752Lys,8/8,\N,Likely pathogenic,Wolfram syndrome,missense_variant,16.61,\N,\N,WFS1
616213,4:6303781:GCT>G,NM_006005.3:c.2262_2263del,NP_005996.2:p.Cys755SerfsTer3,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
616214,4:6303785:T>C,NM_006005.3:c.2263T>C,NP_005996.2:p.Cys755Arg,8/8,\N,Likely pathogenic,Diabetes mellitus AND insipidus with optic atrophy AND deafness,missense_variant,23.2,\N,\N,WFS1
616215,4:6303788:C>T,NM_006005.3:c.2266C>T,NP_005996.2:p.Arg756Cys,8/8,\N,Unknown significance,\N,missense_variant,33,0.00232054,EXAC_FIN_AF,WFS1
616216,4:6303791:C>A,NM_006005.3:c.2269C>A,NP_005996.2:p.Leu757Ile,8/8,\N,Pathogenic,Diabetes| type 1| and sensorineural hearing loss,missense_variant,23.2,0.0000159688,EXAC_NFE_AF,WFS1
616217,4:6303797:C>G,NM_006005.3:c.2275C>G,NP_005996.2:p.Leu759Val,8/8,\N,Likely benign,\N,missense_variant,5.069,0.000175747,EXAC_AMR_AF,WFS1
616218,4:6303798:T>A,NM_006005.3:c.2276T>A,NP_005996.2:p.Leu759Gln,8/8,\N,Likely benign,\N,missense_variant,1.323,0.0000159469,EXAC_NFE_AF,WFS1
616219,4:6303802:G>A,NM_006005.3:c.2280G>A,NP_005996.2:p.Leu760=,8/8,\N,Unknown significance,\N,synonymous_variant,2.89,0.000245399,EXAC_SAS_AF,WFS1
616220,4:6303804:C>T,NM_006005.3:c.2282C>T,NP_005996.2:p.Ala761Val,8/8,\N,Unknown significance,\N,missense_variant,24.7,\N,\N,WFS1
616221,4:6303805:C>T,NM_006005.3:c.2283C>T,NP_005996.2:p.Ala761=,8/8,\N,Unknown significance,\N,synonymous_variant,9.853,0.0000613497,EXAC_SAS_AF,WFS1
616222,4:6303806:A>G,NM_006005.3:c.2284A>G,NP_005996.2:p.Lys762Glu,8/8,\N,Unknown significance,\N,missense_variant,25.7,0.0000613346,EXAC_SAS_AF,WFS1
616223,4:6303808:G>A,NM_006005.3:c.2286G>A,NP_005996.2:p.Lys762=,8/8,\N,Unknown significance,\N,synonymous_variant,6.797,0.003125,OTO_US_AF,WFS1
616224,4:6303809:C>T,NM_006005.3:c.2287C>T,NP_005996.2:p.His763Tyr,8/8,\N,Unknown significance,\N,missense_variant,19.49,0.0000613422,EXAC_SAS_AF,WFS1
616225,4:6303810:A>C,NM_006005.3:c.2288A>C,NP_005996.2:p.His763Pro,8/8,\N,Benign,\N,missense_variant,24.3,0.14375,OTO_US_AF,WFS1
616226,4:6303811:C>A,NM_006005.3:c.2289C>A,NP_005996.2:p.His763Gln,8/8,\N,Unknown significance,\N,missense_variant,23.9,0.000122444,EXAC_SAS_AF,WFS1
616227,4:6303812:C>G,NM_006005.3:c.2290C>G,NP_005996.2:p.Pro764Ala,8/8,\N,Likely benign,\N,missense_variant,5.604,0.000457457,EVS_AA_AF,WFS1
616228,4:6303812:C>T,NM_006005.3:c.2290C>T,NP_005996.2:p.Pro764Ser,8/8,\N,Likely benign,\N,missense_variant,10.97,0.0008,1KG_AFR_AF,WFS1
616229,4:6303815:T>C,NM_006005.3:c.2293T>C,NP_005996.2:p.Cys765Arg,8/8,\N,Unknown significance,\N,missense_variant,25.3,\N,\N,WFS1
616230,4:6303816:G>A,NM_006005.3:c.2294G>A,NP_005996.2:p.Cys765Tyr,8/8,\N,Unknown significance,\N,missense_variant,26.1,0.000061192,EXAC_SAS_AF,WFS1
616231,4:6303819:ACAT>A,NM_006005.3:c.2300_2302del,NP_005996.2:p.Ile767del,8/8,\N,Pathogenic,Sensorineural hearing loss,inframe_deletion,17.94,\N,\N,WFS1
616232,4:6303820:C>T,NM_006005.3:c.2298C>T,NP_005996.2:p.His766=,8/8,\N,Unknown significance,\N,synonymous_variant,7.051,0.0025,OTO_JP_AF,WFS1
616233,4:6303821:A>C,NM_006005.3:c.2299A>C,NP_005996.2:p.Ile767Leu,8/8,\N,Unknown significance,\N,missense_variant,12.23,0.0000316236,EXAC_NFE_AF,WFS1
616234,4:6303823:C>T,NM_006005.3:c.2301C>T,NP_005996.2:p.Ile767=,8/8,\N,Unknown significance,\N,synonymous_variant,8.008,\N,\N,WFS1
616235,4:6303832:C>T,NM_006005.3:c.2310C>T,NP_005996.2:p.Phe770=,8/8,\N,Unknown significance,\N,synonymous_variant,10.13,0.000107852,EXAC_AFR_AF,WFS1
616236,4:6303833:G>A,NM_006005.3:c.2311G>A,NP_005996.2:p.Asp771Asn,8/8,\N,Unknown significance,\N,missense_variant,22.8,0.001,1KG_EAS_AF,WFS1
616237,4:6303833:G>C,NM_006005.3:c.2311G>C,NP_005996.2:p.Asp771His,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,27.3,\N,\N,WFS1
616238,4:6303834:A>G,NM_006005.3:c.2312A>G,NP_005996.2:p.Asp771Gly,8/8,\N,Unknown significance,\N,missense_variant,23.9,\N,\N,WFS1
616239,4:6303836:C>T,NM_006005.3:c.2314C>T,NP_005996.2:p.Arg772Cys,8/8,\N,Benign,\N,missense_variant,32,0.0075,OTO_AJ_AF,WFS1
616240,4:6303836:C>CT,NM_006005.3:c.2314_2315insT,NP_005996.2:p.Arg772LeufsTer5,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
616241,4:6303837:G>A,NM_006005.3:c.2315G>A,NP_005996.2:p.Arg772His,8/8,\N,Unknown significance,\N,missense_variant,25.8,0.0000611098,EXAC_SAS_AF,WFS1
616242,4:6303837:G>T,NM_006005.3:c.2315G>T,NP_005996.2:p.Arg772Leu,8/8,\N,Unknown significance,\N,missense_variant,29.5,0.0000157818,EXAC_NFE_AF,WFS1
616243,4:6303838:C>T,NM_006005.3:c.2316C>T,NP_005996.2:p.Arg772=,8/8,\N,Unknown significance,\N,synonymous_variant,7.707,\N,\N,WFS1
616244,4:6303843:A>C,NM_006005.3:c.2321A>C,NP_005996.2:p.Lys774Thr,8/8,\N,Unknown significance,\N,missense_variant,23.1,0.000107021,EXAC_AFR_AF,WFS1
616245,4:6303843:A>T,NM_006005.3:c.2321A>T,NP_005996.2:p.Lys774Met,8/8,\N,Unknown significance,\N,missense_variant,25.9,0.0000157575,EXAC_NFE_AF,WFS1
616246,4:6303844:G>A,NM_006005.3:c.2322G>A,NP_005996.2:p.Lys774=,8/8,\N,Benign,\N,synonymous_variant,6.175,0.1275,OTO_AJ_AF,WFS1
616247,4:6303845:T>G,NM_006005.3:c.2323T>G,NP_005996.2:p.Phe775Val,8/8,\N,Unknown significance,\N,missense_variant,26.5,\N,\N,WFS1
616248,4:6303846:T>G,NM_006005.3:c.2324T>G,NP_005996.2:p.Phe775Cys,8/8,\N,Unknown significance,\N,missense_variant,25.6,\N,\N,WFS1
616249,4:6303849:A>T,NM_006005.3:c.2327A>T,NP_005996.2:p.Glu776Val,8/8,\N,Benign*,\N,missense_variant,27.3,0.0115326,EXAC_FIN_AF,WFS1
616250,4:6303855:C>T,NM_006005.3:c.2333C>T,NP_005996.2:p.Thr778Ile,8/8,\N,Unknown significance,\N,missense_variant,26.7,0.0000610203,EXAC_SAS_AF,WFS1
616251,4:6303856:C>T,NM_006005.3:c.2334C>T,NP_005996.2:p.Thr778=,8/8,\N,Unknown significance,\N,synonymous_variant,12.22,0.00122036,EXAC_AMR_AF,WFS1
616252,4:6303857:G>A,NM_006005.3:c.2335G>A,NP_005996.2:p.Val779Met,8/8,\N,Benign,\N,missense_variant,24,0.0235929,EXAC_AFR_AF,WFS1
616253,4:6303858:T>G,NM_006005.3:c.2336T>G,NP_005996.2:p.Val779Gly,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,25.7,\N,\N,WFS1
616254,4:6303860:G>A,NM_006005.3:c.2338G>A,NP_005996.2:p.Gly780Ser,8/8,\N,Pathogenic,Optic atrophy & sensorineural hearing loss,missense_variant,26.6,\N,\N,WFS1
616255,4:6303860:G>C,NM_006005.3:c.2338G>C,NP_005996.2:p.Gly780Arg,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,26,\N,\N,WFS1
616256,4:6303861:G>C,NM_006005.3:c.2339G>C,NP_005996.2:p.Gly780Ala,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,23.3,\N,\N,WFS1
616257,4:6303863:A>G,NM_006005.3:c.2341A>G,NP_005996.2:p.Met781Val,8/8,\N,Unknown significance,\N,missense_variant,9.093,0.001,1KG_SAS_AF,WFS1
616258,4:6303864:TG>T,NM_006005.3:c.2343del,NP_005996.2:p.Met781IlefsTer81,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,\N,\N,\N,WFS1
616259,4:6303865:G>A,NM_006005.3:c.2343G>A,NP_005996.2:p.Met781Ile,8/8,\N,Unknown significance,\N,missense_variant,18.46,0.000316589,EXAC_AFR_AF,WFS1
616260,4:6303868:A>C,NM_006005.3:c.2346A>C,NP_005996.2:p.Pro782=,8/8,\N,Unknown significance,\N,synonymous_variant,0.001,\N,\N,WFS1
616261,4:6303869:T>C,NM_006005.3:c.2347T>C,NP_005996.2:p.Phe783Leu,8/8,\N,Likely benign,\N,missense_variant,0.002,0.000703235,EXAC_EAS_AF,WFS1
616262,4:6303869:T>G,NM_006005.3:c.2347T>G,NP_005996.2:p.Phe783Val,8/8,\N,Likely benign,\N,missense_variant,2.6,0.0025,OTO_JP_AF,WFS1
616263,4:6303870:TCAG>T,NM_006005.3:c.2353_2355del,NP_005996.2:p.Ser785del,8/8,\N,Unknown significance,\N,inframe_deletion,6.607,0.0000783748,EXAC_NFE_AF,WFS1
616264,4:6303871:C>T,NM_006005.3:c.2349C>T,NP_005996.2:p.Phe783=,8/8,\N,Unknown significance,\N,synonymous_variant,0.289,0.000125388,EXAC_NFE_AF,WFS1
616265,4:6303874:C>T,NM_006005.3:c.2352C>T,NP_005996.2:p.Ser784=,8/8,\N,Unknown significance,\N,synonymous_variant,0.599,0.000457666,EVS_AA_AF,WFS1
616266,4:6303876:G>T,NM_006005.3:c.2354G>T,NP_005996.2:p.Ser785Ile,8/8,\N,Likely benign,\N,missense_variant,11.61,\N,\N,WFS1
616267,4:6303877:C>T,NM_006005.3:c.2355C>T,NP_005996.2:p.Ser785=,8/8,\N,Unknown significance,\N,synonymous_variant,5.168,0.001,1KG_EAS_AF,WFS1
616268,4:6303878:G>A,NM_006005.3:c.2356G>A,NP_005996.2:p.Gly786Ser,8/8,\N,Benign,\N,missense_variant,0.926,0.0113,1KG_AFR_AF,WFS1
616269,4:6303879:G>C,NM_006005.3:c.2357G>C,NP_005996.2:p.Gly786Ala,8/8,\N,Likely benign,\N,missense_variant,0.002,0.0000608569,EXAC_SAS_AF,WFS1
616270,4:6303880:C>T,NM_006005.3:c.2358C>T,NP_005996.2:p.Gly786=,8/8,\N,Unknown significance,\N,synonymous_variant,3.529,0.000229043,EVS_AA_AF,WFS1
616271,4:6303881:GC>AA,NM_006005.3:c.2359_2360delinsAA,NP_005996.2:p.Ala787Asn,8/8,\N,Unknown significance,\N,missense_variant,\N,\N,\N,WFS1
616272,4:6303881:G>A,NM_006005.3:c.2359G>A,NP_005996.2:p.Ala787Thr,8/8,\N,Likely benign,\N,missense_variant,0.004,0.001,1KG_EAS_AF,WFS1
616273,4:6303881:G>C,NM_006005.3:c.2359G>C,NP_005996.2:p.Ala787Pro,8/8,\N,Likely benign,\N,missense_variant,0.021,0.0000156627,EXAC_NFE_AF,WFS1
616274,4:6303882:C>A,NM_006005.3:c.2360C>A,NP_005996.2:p.Ala787Asp,8/8,\N,Likely benign,\N,missense_variant,0.028,0.0000949427,EXAC_NFE_AF,WFS1
616275,4:6303883:T>C,NM_006005.3:c.2361T>C,NP_005996.2:p.Ala787=,8/8,\N,Unknown significance,\N,synonymous_variant,0.002,0.0000158308,EXAC_NFE_AF,WFS1
616276,4:6303886:C>T,NM_006005.3:c.2364C>T,NP_005996.2:p.Asp788=,8/8,\N,Unknown significance,\N,synonymous_variant,0.55,0.003,1KG_AFR_AF,WFS1
616277,4:6303887:G>A,NM_006005.3:c.2365G>A,NP_005996.2:p.Gly789Ser,8/8,\N,Likely benign,\N,missense_variant,0.06,0.0008,1KG_AFR_AF,WFS1
616278,4:6303887:G>T,NM_006005.3:c.2365G>T,NP_005996.2:p.Gly789Cys,8/8,\N,Likely benign,\N,missense_variant,17.39,0.000117869,EXAC_EAS_AF,WFS1
616279,4:6303888:G>C,NM_006005.3:c.2366G>C,NP_005996.2:p.Gly789Ala,8/8,\N,Unknown significance,\N,missense_variant,0.007,0.000110302,EXAC_AFR_AF,WFS1
616280,4:6303891:C>A,NM_006005.3:c.2369C>A,NP_005996.2:p.Ser790Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,28.4,\N,\N,WFS1
616281,4:6303891:C>G,NM_006005.3:c.2369C>G,NP_005996.2:p.Ser790Trp,8/8,\N,Likely benign,\N,missense_variant,11.81,0.000931099,EVS_AA_AF,WFS1
616282,4:6303891:C>T,NM_006005.3:c.2369C>T,NP_005996.2:p.Ser790Leu,8/8,\N,Likely benign,\N,missense_variant,0.374,0.00106207,EXAC_EAS_AF,WFS1
616283,4:6303892:G>A,NM_006005.3:c.2370G>A,NP_005996.2:p.Ser790=,8/8,\N,Benign,\N,synonymous_variant,0.079,0.0129,1KG_AFR_AF,WFS1
616284,4:6303892:G>C,NM_006005.3:c.2370G>C,NP_005996.2:p.Ser790=,8/8,\N,Benign,\N,synonymous_variant,0.007,0.005,OTO_TR_AF,WFS1
616285,4:6303893:C>T,NM_006005.3:c.2371C>T,NP_005996.2:p.Arg791Cys,8/8,\N,Unknown significance,\N,missense_variant,25,0.001,1KG_EAS_AF,WFS1
616286,4:6303894:G>C,NM_006005.3:c.2372G>C,NP_005996.2:p.Arg791Pro,8/8,\N,Unknown significance,\N,missense_variant,22.6,0.0000318532,EXAC_NFE_AF,WFS1
616287,4:6303899:C>T,NM_006005.3:c.2377C>T,NP_005996.2:p.Arg793Cys,8/8,\N,Likely benign,\N,missense_variant,16.06,\N,\N,WFS1
616288,4:6303899:CGC>GAG,NM_006005.3:c.2377_2379delinsGAG,NP_005996.2:p.Arg793Glu,8/8,\N,Unknown significance,\N,missense_variant,\N,\N,\N,WFS1
616289,4:6303900:G>A,NM_006005.3:c.2378G>A,NP_005996.2:p.Arg793His,8/8,\N,Likely benign,\N,missense_variant,2.624,0.00011798,EXAC_EAS_AF,WFS1
616290,4:6303900:G>C,NM_006005.3:c.2378G>C,NP_005996.2:p.Arg793Pro,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,6.518,\N,\N,WFS1
616291,4:6303901:C>T,NM_006005.3:c.2379C>T,NP_005996.2:p.Arg793=,8/8,\N,Unknown significance,\N,synonymous_variant,4.993,0.001,1KG_SAS_AF,WFS1
616292,4:6303901:CGAG>C,NM_006005.3:c.2385_2387del,NP_005996.2:p.Glu795del,8/8,\N,Unknown significance,\N,inframe_deletion,10.18,0.0000613422,EXAC_SAS_AF,WFS1
616293,4:6303902:G>A,NM_006005.3:c.2380G>A,NP_005996.2:p.Glu794Lys,8/8,\N,Benign,\N,missense_variant,23.6,0.0051,1KG_SAS_AF,WFS1
616294,4:6303903:A>G,NM_006005.3:c.2381A>G,NP_005996.2:p.Glu794Gly,8/8,\N,Unknown significance,\N,missense_variant,21.7,0.0000158433,EXAC_NFE_AF,WFS1
616295,4:6303905:G>A,NM_006005.3:c.2383G>A,NP_005996.2:p.Glu795Lys,8/8,\N,Unknown significance,\N,missense_variant,13.04,0.0000613874,EXAC_SAS_AF,WFS1
616296,4:6303907:G>C,NM_006005.3:c.2385G>C,NP_005996.2:p.Glu795Asp,8/8,\N,Unknown significance,\N,missense_variant,0.016,0.000262789,EXAC_AMR_AF,WFS1
616297,4:6303907:G>GGAC,NM_006005.3:c.2390_2392dup,NP_005996.2:p.Asp797dup,8/8,\N,Benign,\N,inframe_insertion,7.819,0.0076111,EXAC_SAS_AF,WFS1
616298,4:6303907:GGAC>G,NM_006005.3:c.2390_2392del,NP_005996.2:p.Asp797del,8/8,\N,Unknown significance,\N,inframe_deletion,8.927,0.000106633,EXAC_AFR_AF,WFS1
616299,4:6303907:G>A,NM_006005.3:c.2385G>A,NP_005996.2:p.Glu795=,8/8,\N,Unknown significance,\N,synonymous_variant,0.015,0.000106633,EXAC_AFR_AF,WFS1
616300,4:6303910:C>T,NM_006005.3:c.2388C>T,NP_005996.2:p.Asp796=,8/8,\N,Unknown significance,\N,synonymous_variant,5.381,0.0000631333,EXAC_NFE_AF,WFS1
616301,4:6303911:G>A,NM_006005.3:c.2389G>A,NP_005996.2:p.Asp797Asn,8/8,\N,Pathogenic,Hearing loss| non-syndromic progressive sensorineural| autosomal dominant,missense_variant,24.1,\N,\N,WFS1
616302,4:6303911:G>T,NM_006005.3:c.2389G>T,NP_005996.2:p.Asp797Tyr,8/8,\N,Pathogenic,Optic atrophy & sensorineural hearing loss,missense_variant,25.5,\N,\N,WFS1
616303,4:6303912:A>T,NM_006005.3:c.2390A>T,NP_005996.2:p.Asp797Val,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24,\N,\N,WFS1
616304,4:6303913:C>T,NM_006005.3:c.2391C>T,NP_005996.2:p.Asp797=,8/8,\N,Benign,\N,synonymous_variant,7.055,0.0072,1KG_SAS_AF,WFS1
616305,4:6303914:G>A,NM_006005.3:c.2392G>A,NP_005996.2:p.Val798Ile,8/8,\N,Likely benign,\N,missense_variant,8.546,0.00115473,EXAC_OTH_AF,WFS1
616306,4:6303914:G>C,NM_006005.3:c.2392G>C,NP_005996.2:p.Val798Leu,8/8,\N,Likely benign,\N,missense_variant,9.65,0.0000157109,EXAC_NFE_AF,WFS1
616307,4:6303914:G>GGAC,NM_006005.3:c.2392_2393insGAC,NP_005996.2:p.Val798delinsGlyLeu,8/8,\N,Pathogenic,Wolfram syndrome,protein_altering_variant,7.492,\N,\N,WFS1
616308,4:6303919:C>G,NM_006005.3:c.2397C>G,NP_005996.2:p.Thr799=,8/8,\N,Unknown significance,\N,synonymous_variant,1.817,0.0000156843,EXAC_NFE_AF,WFS1
616309,4:6303920:A>G,NM_006005.3:c.2398A>G,NP_005996.2:p.Lys800Glu,8/8,\N,Unknown significance,\N,missense_variant,23.3,0.000156755,EXAC_NFE_AF,WFS1
616310,4:6303923:G>T,NM_006005.3:c.2401G>T,NP_005996.2:p.Asp801Tyr,8/8,\N,Unknown significance,\N,missense_variant,26.7,0.00006141,EXAC_SAS_AF,WFS1
616311,4:6303926:A>G,NM_006005.3:c.2404A>G,NP_005996.2:p.Ile802Val,8/8,\N,Unknown significance,\N,missense_variant,10.78,0.0000156426,EXAC_NFE_AF,WFS1
616312,4:6303928:C>T,NM_006005.3:c.2406C>T,NP_005996.2:p.Ile802=,8/8,\N,Likely benign,\N,synonymous_variant,13.2,0.0043,1KG_AMR_AF,WFS1
616313,4:6303928:C>G,NM_006005.3:c.2406C>G,NP_005996.2:p.Ile802Met,8/8,\N,Unknown significance,\N,missense_variant,24,0.000788229,EXAC_AMR_AF,WFS1
616314,4:6303929:G>A,NM_006005.3:c.2407G>A,NP_005996.2:p.Val803Met,8/8,\N,Unknown significance,\N,missense_variant,26.7,0.000031252,EXAC_NFE_AF,WFS1
616315,4:6303929:G>C,NM_006005.3:c.2407G>C,NP_005996.2:p.Val803Leu,8/8,\N,Unknown significance,\N,missense_variant,23.7,0,EXAC_ALL_AF|EXAC_AFR_AF|EXAC_AMR_AF|EXAC_EAS_AF|EXAC_FIN_AF|EXAC_NFE_AF|EXAC_OTH_AF|EXAC_SAS_AF,WFS1
616316,4:6303932:C>T,NM_006005.3:c.2410C>T,NP_005996.2:p.Leu804=,8/8,\N,Unknown significance,\N,synonymous_variant,8.311,0.0000312266,EXAC_NFE_AF,WFS1
616317,4:6303933:T>C,NM_006005.3:c.2411T>C,NP_005996.2:p.Leu804Pro,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,26.2,\N,\N,WFS1
616318,4:6303935:C>T,NM_006005.3:c.2413C>T,NP_005996.2:p.Arg805Trp,8/8,\N,Unknown significance,\N,missense_variant,33,0.000118008,EXAC_EAS_AF,WFS1
616319,4:6303936:G>A,NM_006005.3:c.2414G>A,NP_005996.2:p.Arg805Gln,8/8,\N,Unknown significance,\N,missense_variant,24.8,0.000226963,EVS_AA_AF,WFS1
616320,4:6303937:G>T,NM_006005.3:c.2415G>T,NP_005996.2:p.Arg805=,8/8,\N,Unknown significance,\N,synonymous_variant,0.812,0.000123229,EXAC_SAS_AF,WFS1
616321,4:6303938:G>C,NM_006005.3:c.2416G>C,NP_005996.2:p.Ala806Pro,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,27,0.0000874585,EXAC_AMR_AF,WFS1
616322,4:6303941:A>C,NM_006005.3:c.2419A>C,NP_005996.2:p.Ser807Arg,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,24.8,\N,\N,WFS1
616323,4:6303942:G>C,NM_006005.3:c.2420G>C,NP_005996.2:p.Ser807Thr,8/8,\N,Unknown significance,\N,missense_variant,23.3,0.0000616447,EXAC_SAS_AF,WFS1
616324,4:6303942:G>T,NM_006005.3:c.2420G>T,NP_005996.2:p.Ser807Ile,8/8,\N,Unknown significance,\N,missense_variant,26.4,0.0000616447,EXAC_SAS_AF,WFS1
616325,4:6303945:G>A,NM_006005.3:c.2423G>A,NP_005996.2:p.Ser808Asn,8/8,\N,Likely benign,\N,missense_variant,2.394,0.0000155477,EXAC_NFE_AF,WFS1
616326,4:6303946:C>T,NM_006005.3:c.2424C>T,NP_005996.2:p.Ser808=,8/8,\N,Unknown significance,\N,synonymous_variant,13.61,0.00114416,EXAC_OTH_AF,WFS1
616327,4:6303947:G>A,NM_006005.3:c.2425G>A,NP_005996.2:p.Glu809Lys,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,27,\N,\N,WFS1
616328,4:6303954:A>G,NM_006005.3:c.2432A>G,NP_005996.2:p.Lys811Arg,8/8,\N,Likely benign,\N,missense_variant,1.133,0.000873668,EXAC_AMR_AF,WFS1
616329,4:6303955:G>A,NM_006005.3:c.2433G>A,NP_005996.2:p.Lys811=,8/8,\N,Benign,\N,synonymous_variant,4.992,0.936362,EXAC_EAS_AF,WFS1
616330,4:6303955:G>C,NM_006005.3:c.2433G>C,NP_005996.2:p.Lys811Asn,8/8,\N,Unknown significance,\N,missense_variant,23.3,0.0000153186,EXAC_NFE_AF,WFS1
616331,4:6303958:C>T,NM_006005.3:c.2436C>T,NP_005996.2:p.Ser812=,8/8,\N,Unknown significance,\N,synonymous_variant,11.3,0.00181571,EVS_AA_AF,WFS1
616332,4:6303959:G>A,NM_006005.3:c.2437G>A,NP_005996.2:p.Val813Met,8/8,\N,Unknown significance,\N,missense_variant,24.2,0.0000870322,EXAC_AMR_AF,WFS1
616333,4:6303967:C>A,NM_006005.3:c.2445C>A,NP_005996.2:p.Leu815=,8/8,\N,Unknown significance,\N,synonymous_variant,8.762,0.000151469,EXAC_FIN_AF,WFS1
616334,4:6303967:C>G,NM_006005.3:c.2445C>G,NP_005996.2:p.Leu815=,8/8,\N,Unknown significance,\N,synonymous_variant,1.26,0.0008,1KG_AFR_AF,WFS1
616335,4:6303967:C>T,NM_006005.3:c.2445C>T,NP_005996.2:p.Leu815=,8/8,\N,Unknown significance,\N,synonymous_variant,5.801,0.000174186,EXAC_AMR_AF,WFS1
616336,4:6303968:A>C,NM_006005.3:c.2446A>C,NP_005996.2:p.Ser816Arg,8/8,\N,Likely benign,\N,missense_variant,0.099,\N,\N,WFS1
616337,4:6303968:A>G,NM_006005.3:c.2446A>G,NP_005996.2:p.Ser816Gly,8/8,\N,Likely benign,\N,missense_variant,0.012,\N,\N,WFS1
616338,4:6303971:C>A,NM_006005.3:c.2449C>A,NP_005996.2:p.Leu817Met,8/8,\N,Unknown significance,\N,missense_variant,25.5,0.000116822,EXAC_EAS_AF,WFS1
616339,4:6303971:C>T,NM_006005.3:c.2449C>T,NP_005996.2:p.Leu817=,8/8,\N,Unknown significance,\N,synonymous_variant,9.228,0.0000987362,EXAC_AFR_AF,WFS1
616340,4:6303974:C>T,NM_006005.3:c.2452C>T,NP_005996.2:p.Arg818Cys,8/8,\N,Benign,\N,missense_variant,32,0.04,OTO_AJ_AF|OTO_TR_AF,WFS1
616341,4:6303975:G>A,NM_006005.3:c.2453G>A,NP_005996.2:p.Arg818His,8/8,\N,Unknown significance,\N,missense_variant,22.8,0.002,1KG_SAS_AF,WFS1
616342,4:6303976:C>T,NM_006005.3:c.2454C>T,NP_005996.2:p.Arg818=,8/8,\N,Likely benign,\N,synonymous_variant,9.847,0.000116279,EVS_EA_AF,WFS1
616343,4:6303977:C>T,NM_006005.3:c.2455C>T,NP_005996.2:p.Gln819Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,41,\N,\N,WFS1
616344,4:6303980:G>C,NM_006005.3:c.2458G>C,NP_005996.2:p.Gly820Arg,8/8,\N,Unknown significance,\N,missense_variant,26.8,0.0000153341,EXAC_NFE_AF,WFS1
616345,4:6303981:G>A,NM_006005.3:c.2459G>A,NP_005996.2:p.Gly820Asp,8/8,\N,Unknown significance,\N,missense_variant,26.4,0.0000985416,EXAC_AFR_AF,WFS1
616346,4:6303981:G>T,NM_006005.3:c.2459G>T,NP_005996.2:p.Gly820Val,8/8,\N,Unknown significance,\N,missense_variant,26.7,0.00015337,EXAC_NFE_AF,WFS1
616347,4:6303986:CTCA>C,NM_006005.3:c.2467_2469del,NP_005996.2:p.Ile823del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,14.69,\N,\N,WFS1
616348,4:6303988:C>A,NM_006005.3:c.2466C>A,NP_005996.2:p.Leu822=,8/8,\N,Unknown significance,\N,synonymous_variant,10.2,0.0008,1KG_AFR_AF,WFS1
616349,4:6303988:C>T,NM_006005.3:c.2466C>T,NP_005996.2:p.Leu822=,8/8,\N,Unknown significance,\N,synonymous_variant,7.5,0.000174125,EXAC_AMR_AF,WFS1
616350,4:6303991:C>T,NM_006005.3:c.2469C>T,NP_005996.2:p.Ile823=,8/8,\N,Benign,\N,synonymous_variant,13.2,0.0508398,EVS_AA_AF,WFS1
616351,4:6303991:C>A,NM_006005.3:c.2469C>A,NP_005996.2:p.Ile823=,8/8,\N,Unknown significance,\N,synonymous_variant,16.61,\N,\N,WFS1
616352,4:6303991:C>G,NM_006005.3:c.2469C>G,NP_005996.2:p.Ile823Met,8/8,\N,Unknown significance,\N,missense_variant,20.7,0.0000627353,EXAC_SAS_AF,WFS1
616353,4:6303992:G>A,NM_006005.3:c.2470G>A,NP_005996.2:p.Glu824Lys,8/8,\N,Unknown significance,\N,missense_variant,26,0.000116279,EVS_EA_AF,WFS1
616354,4:6303994:G>A,NM_006005.3:c.2472G>A,NP_005996.2:p.Glu824=,8/8,\N,Unknown significance,\N,synonymous_variant,2.504,0.0000153257,EXAC_NFE_AF,WFS1
616355,4:6304001:A>C,NM_006005.3:c.2479A>C,NP_005996.2:p.Thr827Pro,8/8,\N,Unknown significance,\N,missense_variant,23.1,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616356,4:6304003:C>A,NM_006005.3:c.2481C>A,NP_005996.2:p.Thr827=,8/8,\N,Unknown significance,\N,synonymous_variant,11.98,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616357,4:6304004:A>G,NM_006005.3:c.2482A>G,NP_005996.2:p.Ile828Val,8/8,\N,Likely benign,\N,missense_variant,0.055,0.0000153355,EXAC_NFE_AF,WFS1
616358,4:6304005:T>TGA,NM_006005.3:c.2483_2484insGA,NP_005996.2:p.Ile828MetfsTer35,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
616359,4:6304006:C>A,NM_006005.3:c.2484C>A,NP_005996.2:p.Ile828=,8/8,\N,Unknown significance,\N,synonymous_variant,13.68,0.000197668,EXAC_AFR_AF,WFS1
616360,4:6304006:CCTGGAGGGCCG>C,NM_006005.3:c.2486_2496del,NP_005996.2:p.Leu829ProfsTer107,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
616361,4:6304008:T>C,NM_006005.3:c.2486T>C,NP_005996.2:p.Leu829Pro,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,25.7,\N,\N,WFS1
616362,4:6304011:A>C,NM_006005.3:c.2489A>C,NP_005996.2:p.Glu830Ala,8/8,\N,Pathogenic,Diabetes| neonatal,missense_variant,25.6,\N,\N,WFS1
616363,4:6304013:G>A,NM_006005.3:c.2491G>A,NP_005996.2:p.Gly831Ser,8/8,\N,Pathogenic,Hearing impairment,missense_variant,23.6,\N,\N,WFS1
616364,4:6304014:G>A,NM_006005.3:c.2492G>A,NP_005996.2:p.Gly831Asp,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,26.2,0.000116279,EVS_EA_AF,WFS1
616365,4:6304014:G>C,NM_006005.3:c.2492G>C,NP_005996.2:p.Gly831Ala,8/8,\N,Pathogenic,\N,missense_variant,24.8,\N,\N,WFS1
616366,4:6304016:C>G,NM_006005.3:c.2494C>G,NP_005996.2:p.Arg832Gly,8/8,\N,Unknown significance,\N,missense_variant,24.6,0.0000990491,EXAC_AFR_AF,WFS1
616367,4:6304016:C>T,NM_006005.3:c.2494C>T,NP_005996.2:p.Arg832Cys,8/8,\N,Unknown significance,\N,missense_variant,33,0.000465116,EVS_EA_AF,WFS1
616368,4:6304017:G>A,NM_006005.3:c.2495G>A,NP_005996.2:p.Arg832His,8/8,\N,Unknown significance,\N,missense_variant,25.4,0.000116279,EVS_EA_AF,WFS1
616369,4:6304019:C>T,NM_006005.3:c.2497C>T,NP_005996.2:p.Leu833=,8/8,\N,Unknown significance,\N,synonymous_variant,8.596,0.000087108,EXAC_AMR_AF,WFS1
616370,4:6304022:G>A,NM_006005.3:c.2500G>A,NP_005996.2:p.Gly834Ser,8/8,\N,Unknown significance,\N,missense_variant,27.1,\N,\N,WFS1
616371,4:6304026:G>GC,NM_006005.3:c.2505dup,NP_005996.2:p.Lys836GlnfsTer104,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
616372,4:6304029:A>C,NM_006005.3:c.2507A>C,NP_005996.2:p.Lys836Thr,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,22.9,\N,\N,WFS1
616373,4:6304030:G>C,NM_006005.3:c.2508G>C,NP_005996.2:p.Lys836Asn,8/8,\N,Pathogenic,Optic atrophy| autosomal dominant| with hearing impairment,missense_variant,23.7,\N,\N,WFS1
616374,4:6304032:G>A,NM_006005.3:c.2510G>A,NP_005996.2:p.Trp837Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,40,\N,\N,WFS1
616375,4:6304035:C>T,NM_006005.3:c.2513C>T,NP_005996.2:p.Pro838Leu,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,24.8,0.000226963,EVS_AA_AF,WFS1
616376,4:6304036:T>C,NM_006005.3:c.2514T>C,NP_005996.2:p.Pro838=,8/8,\N,Unknown significance,\N,synonymous_variant,0.03,0.0011236,EXAC_OTH_AF,WFS1
616377,4:6304038:T>C,NM_006005.3:c.2516T>C,NP_005996.2:p.Val839Ala,8/8,\N,Unknown significance,\N,missense_variant,5.645,0.000116932,EXAC_EAS_AF,WFS1
616378,4:6304038:T>G,NM_006005.3:c.2516T>G,NP_005996.2:p.Val839Gly,8/8,\N,Unknown significance,\N,missense_variant,22.7,0.0000153728,EXAC_NFE_AF,WFS1
616379,4:6304042:C>T,NM_006005.3:c.2520C>T,NP_005996.2:p.Phe840=,8/8,\N,Unknown significance,\N,synonymous_variant,11.77,0.000396432,EXAC_AFR_AF,WFS1
616380,4:6304043:G>T,NM_006005.3:c.2521G>T,NP_005996.2:p.Glu841Ter,8/8,\N,Unknown significance,\N,stop_gained,49,0.0000870777,EXAC_AMR_AF,WFS1
616381,4:6304046:C>T,NM_006005.3:c.2524C>T,NP_005996.2:p.Leu842Phe,8/8,\N,Likely pathogenic,Wolfram syndrome,missense_variant,25.8,\N,\N,WFS1
616382,4:6304050:A>G,NM_006005.3:c.2528A>G,NP_005996.2:p.Lys843Arg,8/8,\N,Unknown significance,\N,missense_variant,21.3,0.0000870777,EXAC_AMR_AF,WFS1
616383,4:6304052:G>A,NM_006005.3:c.2530G>A,NP_005996.2:p.Ala844Thr,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,25.1,\N,\N,WFS1
616384,4:6304053:C>G,NM_006005.3:c.2531C>G,NP_005996.2:p.Ala844Gly,8/8,\N,Unknown significance,\N,missense_variant,24.3,0.0000153775,EXAC_NFE_AF,WFS1
616385,4:6304053:C>T,NM_006005.3:c.2531C>T,NP_005996.2:p.Ala844Val,8/8,\N,Unknown significance,\N,missense_variant,25.5,0.000226963,EVS_AA_AF,WFS1
616386,4:6304054:C>T,NM_006005.3:c.2532C>T,NP_005996.2:p.Ala844=,8/8,\N,Unknown significance,\N,synonymous_variant,10.1,0.000181973,EXAC_SAS_AF,WFS1
616387,4:6304055:A>G,NM_006005.3:c.2533A>G,NP_005996.2:p.Ile845Val,8/8,\N,Unknown significance,\N,missense_variant,11.63,0.0000606502,EXAC_SAS_AF,WFS1
616388,4:6304056:T>G,NM_006005.3:c.2534T>G,NP_005996.2:p.Ile845Ser,8/8,\N,Unknown significance,\N,missense_variant,26.1,0.000233809,EXAC_EAS_AF,WFS1
616389,4:6304057:C>T,NM_006005.3:c.2535C>T,NP_005996.2:p.Ile845=,8/8,\N,Unknown significance,\N,synonymous_variant,8.137,0.000116279,EVS_EA_AF,WFS1
616390,4:6304058:A>G,NM_006005.3:c.2536A>G,NP_005996.2:p.Ser846Gly,8/8,\N,Likely benign,\N,missense_variant,0.65,0.001,1KG_EAS_AF,WFS1
616391,4:6304059:G>T,NM_006005.3:c.2537G>T,NP_005996.2:p.Ser846Ile,8/8,\N,Unknown significance,\N,missense_variant,23.4,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616392,4:6304060:C>T,NM_006005.3:c.2538C>T,NP_005996.2:p.Ser846=,8/8,\N,Unknown significance,\N,synonymous_variant,4.872,0.000116795,EXAC_EAS_AF,WFS1
616393,4:6304066:C>T,NM_006005.3:c.2544C>T,NP_005996.2:p.Leu848=,8/8,\N,Unknown significance,\N,synonymous_variant,6.276,\N,\N,WFS1
616394,4:6304067:A>C,NM_006005.3:c.2545A>C,NP_005996.2:p.Asn849His,8/8,\N,Unknown significance,\N,missense_variant,23.8,0.000098561,EXAC_AFR_AF,WFS1
616395,4:6304068:A>G,NM_006005.3:c.2546A>G,NP_005996.2:p.Asn849Ser,8/8,\N,Unknown significance,\N,missense_variant,18.57,0.000116713,EXAC_EAS_AF,WFS1
616396,4:6304069:C>A,NM_006005.3:c.2547C>A,NP_005996.2:p.Asn849Lys,8/8,\N,Unknown significance,\N,missense_variant,23.9,\N,\N,WFS1
616397,4:6304071:G>A,NM_006005.3:c.2549G>A,NP_005996.2:p.Cys850Tyr,8/8,\N,Unknown significance,\N,missense_variant,25.8,0.0000606281,EXAC_SAS_AF,WFS1
616398,4:6304073:A>ATG,NM_006005.3:c.2552_2553dup,NP_005996.2:p.Ala852TrpfsTer11,8/8,\N,Unknown significance,\N,frameshift_variant,29.7,\N,\N,WFS1
616399,4:6304074:T>G,NM_006005.3:c.2552T>G,NP_005996.2:p.Met851Arg,8/8,\N,Unknown significance,\N,missense_variant,9.626,0.0000870019,EXAC_AMR_AF,WFS1
616400,4:6304076:G>GCCCAGC,NM_006005.3:c.2555_2560dup,NP_005996.2:p.Gln853_Leu854insProGln,8/8,\N,Unknown significance,\N,inframe_insertion,11.4,\N,\N,WFS1
616401,4:6304077:C>T,NM_006005.3:c.2555C>T,NP_005996.2:p.Ala852Val,8/8,\N,Unknown significance,\N,missense_variant,24.1,\N,\N,WFS1
616402,4:6304078:C>G,NM_006005.3:c.2556C>G,NP_005996.2:p.Ala852=,8/8,\N,Unknown significance,\N,synonymous_variant,4.909,0.0000606134,EXAC_SAS_AF,WFS1
616403,4:6304082:C>T,NM_006005.3:c.2560C>T,NP_005996.2:p.Leu854Phe,8/8,\N,Unknown significance,\N,missense_variant,22.3,0.000303214,EXAC_FIN_AF,WFS1
616404,4:6304083:T>C,NM_006005.3:c.2561T>C,NP_005996.2:p.Leu854Pro,8/8,\N,Unknown significance,\N,missense_variant,4.504,0.0000870019,EXAC_AMR_AF,WFS1
616405,4:6304085:T>C,NM_006005.3:c.2563T>C,NP_005996.2:p.Ser855Pro,8/8,\N,Likely benign,\N,missense_variant,0.003,0.0031,1KG_SAS_AF,WFS1
616406,4:6304086:C>T,NM_006005.3:c.2564C>T,NP_005996.2:p.Ser855Leu,8/8,\N,Likely benign,\N,missense_variant,0.01,0.001,1KG_SAS_AF,WFS1
616407,4:6304087:A>G,NM_006005.3:c.2565A>G,NP_005996.2:p.Ser855=,8/8,\N,Benign,\N,synonymous_variant,0.002,0.936831,EXAC_EAS_AF,WFS1
616408,4:6304087:A>C,NM_006005.3:c.2565A>C,NP_005996.2:p.Ser855=,8/8,\N,Unknown significance,\N,synonymous_variant,0.001,\N,\N,WFS1
616409,4:6304087:A>T,NM_006005.3:c.2565A>T,NP_005996.2:p.Ser855=,8/8,\N,Unknown significance,\N,synonymous_variant,0.001,0.000349,EXAC_EAS_AF,WFS1
616410,4:6304089:C>T,NM_006005.3:c.2567C>T,NP_005996.2:p.Pro856Leu,8/8,\N,Unknown significance,\N,missense_variant,23.9,\N,\N,WFS1
616411,4:6304092:C>T,NM_006005.3:c.2570C>T,NP_005996.2:p.Thr857Ile,8/8,\N,Likely benign,\N,missense_variant,2.037,0.001,1KG_SAS_AF,WFS1
616412,4:6304095:G>A,NM_006005.3:c.2573G>A,NP_005996.2:p.Arg858Lys,8/8,\N,Likely benign,\N,missense_variant,0.001,\N,\N,WFS1
616413,4:6304097:C>T,NM_006005.3:c.2575C>T,NP_005996.2:p.Arg859Trp,8/8,\N,Unknown significance,\N,missense_variant,22.8,0.00018184,EXAC_SAS_AF,WFS1
616414,4:6304098:G>A,NM_006005.3:c.2576G>A,NP_005996.2:p.Arg859Gln,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,25.5,0.000116279,EVS_EA_AF,WFS1
616415,4:6304098:G>C,NM_006005.3:c.2576G>C,NP_005996.2:p.Arg859Pro,8/8,\N,Pathogenic,Sensorineural hearing loss,missense_variant,25.2,\N,\N,WFS1
616416,4:6304100:C>G,NM_006005.3:c.2578C>G,NP_005996.2:p.His860Asp,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,21.4,\N,\N,WFS1
616417,4:6304102:C>A,NM_006005.3:c.2580C>A,NP_005996.2:p.His860Gln,8/8,\N,Unknown significance,\N,missense_variant,0.487,0.000030581,EXAC_NFE_AF,WFS1
616418,4:6304102:C>T,NM_006005.3:c.2580C>T,NP_005996.2:p.His860=,8/8,\N,Unknown significance,\N,synonymous_variant,3.285,0.000030581,EXAC_NFE_AF,WFS1
616419,4:6304103:G>A,NM_006005.3:c.2581G>A,NP_005996.2:p.Val861Met,8/8,\N,Unknown significance,\N,missense_variant,24.4,0.0000152915,EXAC_NFE_AF,WFS1
616420,4:6304104:T>G,NM_006005.3:c.2582T>G,NP_005996.2:p.Val861Gly,8/8,\N,Likely pathogenic,\N,missense_variant,23.7,\N,\N,WFS1
616421,4:6304105:G>A,NM_006005.3:c.2583G>A,NP_005996.2:p.Val861=,8/8,\N,Unknown significance,\N,synonymous_variant,0.224,0.0000606208,EXAC_SAS_AF,WFS1
616422,4:6304106:A>T,NM_006005.3:c.2584A>T,NP_005996.2:p.Lys862Ter,8/8,\N,Unknown significance,\N,stop_gained,40,0.0000152929,EXAC_NFE_AF,WFS1
616423,4:6304108:G>A,NM_006005.3:c.2586G>A,NP_005996.2:p.Lys862=,8/8,\N,Unknown significance,\N,synonymous_variant,2.408,0.000116279,EVS_EA_AF,WFS1
616424,4:6304111:C>A,NM_006005.3:c.2589C>A,NP_005996.2:p.Ile863=,8/8,\N,Unknown significance,\N,synonymous_variant,13.32,0.0000152957,EXAC_NFE_AF,WFS1
616425,4:6304111:C>G,NM_006005.3:c.2589C>G,NP_005996.2:p.Ile863Met,8/8,\N,Unknown significance,\N,missense_variant,21.4,0.000173792,EXAC_AMR_AF,WFS1
616426,4:6304111:C>T,NM_006005.3:c.2589C>T,NP_005996.2:p.Ile863=,8/8,\N,Unknown significance,\N,synonymous_variant,10.03,0.000232558,EVS_EA_AF,WFS1
616427,4:6304112:G>A,NM_006005.3:c.2590G>A,NP_005996.2:p.Glu864Lys,8/8,\N,Pathogenic,Optic atrophy| autosomal dominant| with hearing impairment,missense_variant,28.6,\N,\N,WFS1
616428,4:6304112:G>T,NM_006005.3:c.2590G>T,NP_005996.2:p.Glu864Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,46,\N,\N,WFS1
616429,4:6304115:C>A,NM_006005.3:c.2593C>A,NP_005996.2:p.His865Asn,8/8,\N,Likely benign,\N,missense_variant,18.25,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616430,4:6304117:C>A,NM_006005.3:c.2595C>A,NP_005996.2:p.His865Gln,8/8,\N,Likely benign,\N,missense_variant,11.79,0.0000306035,EXAC_NFE_AF,WFS1
616431,4:6304117:C>T,NM_006005.3:c.2595C>T,NP_005996.2:p.His865=,8/8,\N,Unknown significance,\N,synonymous_variant,11.31,0.002,1KG_EAS_AF,WFS1
616432,4:6304118:G>A,NM_006005.3:c.2596G>A,NP_005996.2:p.Asp866Asn,8/8,\N,Benign,\N,missense_variant,25,0.0278,1KG_EAS_AF,WFS1
616433,4:6304118:G>T,NM_006005.3:c.2596G>T,NP_005996.2:p.Asp866Tyr,8/8,\N,Unknown significance,\N,missense_variant,27.5,0.000868961,EXAC_AMR_AF,WFS1
616434,4:6304120:C>G,NM_006005.3:c.2598C>G,NP_005996.2:p.Asp866Glu,8/8,\N,Unknown significance,\N,missense_variant,27.4,0.0000153013,EXAC_NFE_AF,WFS1
616435,4:6304123:G>A,NM_006005.3:c.2601G>A,NP_005996.2:p.Trp867Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,43,\N,\N,WFS1
616436,4:6304124:C>T,NM_006005.3:c.2602C>T,NP_005996.2:p.Arg868Cys,8/8,\N,Unknown significance,\N,missense_variant,32,0.001,1KG_SAS_AF,WFS1
616437,4:6304125:G>A,NM_006005.3:c.2603G>A,NP_005996.2:p.Arg868His,8/8,\N,Likely benign,\N,missense_variant,31,0.000303324,EXAC_SAS_AF,WFS1
616438,4:6304125:G>C,NM_006005.3:c.2603G>C,NP_005996.2:p.Arg868Pro,8/8,\N,Benign,\N,missense_variant,29.8,0.005,OTO_TR_AF,WFS1
616439,4:6304126:C>T,NM_006005.3:c.2604C>T,NP_005996.2:p.Arg868=,8/8,\N,Unknown significance,\N,synonymous_variant,10.36,0.000015305,EXAC_NFE_AF,WFS1
616440,4:6304128:G>A,NM_006005.3:c.2606G>A,NP_005996.2:p.Ser869Asn,8/8,\N,Unknown significance,\N,missense_variant,12.84,\N,\N,WFS1
616441,4:6304130:A>C,NM_006005.3:c.2608A>C,NP_005996.2:p.Thr870Pro,8/8,\N,Unknown significance,\N,missense_variant,19.02,0.0000606722,EXAC_SAS_AF,WFS1
616442,4:6304132:C>T,NM_006005.3:c.2610C>T,NP_005996.2:p.Thr870=,8/8,\N,Likely benign,\N,synonymous_variant,11.96,0.00113122,EXAC_OTH_AF,WFS1
616443,4:6304132:C>A,NM_006005.3:c.2610C>A,NP_005996.2:p.Thr870=,8/8,\N,Unknown significance,\N,synonymous_variant,16.17,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616444,4:6304133:G>A,NM_006005.3:c.2611G>A,NP_005996.2:p.Val871Met,8/8,\N,Benign,\N,missense_variant,21.5,0.0126486,EXAC_FIN_AF,WFS1
616445,4:6304134:T>G,NM_006005.3:c.2612T>G,NP_005996.2:p.Val871Gly,8/8,\N,Unknown significance,\N,missense_variant,24.2,0.000667476,EXAC_SAS_AF,WFS1
616446,4:6304137:A>G,NM_006005.3:c.2615A>G,NP_005996.2:p.His872Arg,8/8,\N,Unknown significance,\N,missense_variant,18.45,0.0000153186,EXAC_NFE_AF,WFS1
616447,4:6304141:C>T,NM_006005.3:c.2619C>T,NP_005996.2:p.Gly873=,8/8,\N,Unknown significance,\N,synonymous_variant,12.99,0.000453926,EVS_AA_AF,WFS1
616448,4:6304142:G>A,NM_006005.3:c.2620G>A,NP_005996.2:p.Ala874Thr,8/8,\N,Unknown significance,\N,missense_variant,29.9,0.001,1KG_EAS_AF,WFS1
616449,4:6304143:C>G,NM_006005.3:c.2621C>G,NP_005996.2:p.Ala874Gly,8/8,\N,Unknown significance,\N,missense_variant,24.1,0.000116279,EVS_EA_AF,WFS1
616450,4:6304144:C>T,NM_006005.3:c.2622C>T,NP_005996.2:p.Ala874=,8/8,\N,Unknown significance,\N,synonymous_variant,14.52,0.00317749,EVS_AA_AF,WFS1
616451,4:6304145:G>A,NM_006005.3:c.2623G>A,NP_005996.2:p.Val875Met,8/8,\N,Likely benign,\N,missense_variant,11.18,0.001,1KG_SAS_AF,WFS1
616452,4:6304149:A>C,NM_006005.3:c.2627A>C,NP_005996.2:p.Lys876Thr,8/8,\N,Unknown significance,\N,missense_variant,25.6,0.00272356,EVS_AA_AF,WFS1
616453,4:6304149:A>G,NM_006005.3:c.2627A>G,NP_005996.2:p.Lys876Arg,8/8,\N,Unknown significance,\N,missense_variant,18.49,0.000196889,EXAC_AFR_AF,WFS1
616454,4:6304153:C>T,NM_006005.3:c.2631C>T,NP_005996.2:p.Phe877=,8/8,\N,Unknown significance,\N,synonymous_variant,13.14,0.000226963,EVS_AA_AF,WFS1
616455,4:6304154:G>A,NM_006005.3:c.2632G>A,NP_005996.2:p.Ala878Thr,8/8,\N,Unknown significance,\N,missense_variant,23.3,0.002,1KG_EUR_AF,WFS1
616456,4:6304155:CCTTCGA>C,NM_006005.3:c.2638_2643del,NP_005996.2:p.Asp880_Phe881del,8/8,\N,Pathogenic,Wolfram syndrome,inframe_deletion,14.91,\N,\N,WFS1
616457,4:6304159:C>T,NM_006005.3:c.2637C>T,NP_005996.2:p.Phe879=,8/8,\N,Unknown significance,\N,synonymous_variant,13.56,0.000116904,EXAC_EAS_AF,WFS1
616458,4:6304160:G>A,NM_006005.3:c.2638G>A,NP_005996.2:p.Asp880Asn,8/8,\N,Benign,\N,missense_variant,14.07,0.005,OTO_TR_AF,WFS1
616459,4:6304160:G>C,NM_006005.3:c.2638G>C,NP_005996.2:p.Asp880His,8/8,\N,Unknown significance,\N,missense_variant,25.7,0.0000153728,EXAC_NFE_AF,WFS1
616460,4:6304161:ACTT>A,NM_006005.3:c.2643_2645del,NP_005996.2:p.Phe884del,8/8,\N,Unknown significance,\N,inframe_deletion,14.41,\N,\N,WFS1
616461,4:6304162:C>T,NM_006005.3:c.2640C>T,NP_005996.2:p.Asp880=,8/8,\N,Unknown significance,\N,synonymous_variant,7.824,0.0008,1KG_AFR_AF,WFS1
616462,4:6304162:CTTCT>C,NM_006005.3:c.2643_2646del,NP_005996.2:p.Phe882SerfsTer69,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
616463,4:6304163:TTC>T,NM_006005.3:c.2643_2644del,NP_005996.2:p.Phe883LeufsTer56,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,0.000182504,EXAC_SAS_AF,WFS1
616464,4:6304165:CTT>C,NM_006005.3:c.2647_2648del,NP_005996.2:p.Phe883LeufsTer56,8/8,\N,Unknown significance,\N,frameshift_variant,35,0.0000870928,EXAC_AMR_AF,WFS1
616465,4:6304167:TTTTC>T,NM_006005.3:c.2648_2651del,NP_005996.2:p.Phe883SerfsTer68,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,0.000107798,EXAC_NFE_AF,WFS1
616466,4:6304167:T>G,NM_006005.3:c.2645T>G,NP_005996.2:p.Phe882Cys,8/8,\N,Unknown significance,\N,missense_variant,26.5,0.000233863,EXAC_EAS_AF,WFS1
616467,4:6304170:TC>T,NM_006005.3:c.2649del,NP_005996.2:p.Phe884SerfsTer68,8/8,\N,Pathogenic,Wolfram syndrome,frameshift_variant,35,\N,\N,WFS1
616468,4:6304172:T>G,NM_006005.3:c.2650T>G,NP_005996.2:p.Phe884Val,8/8,\N,Likely benign,\N,missense_variant,13.94,0.0000154526,EXAC_NFE_AF,WFS1
616469,4:6304173:T>A,NM_006005.3:c.2651T>A,NP_005996.2:p.Phe884Tyr,8/8,\N,Unknown significance,\N,missense_variant,6.596,\N,\N,WFS1
616470,4:6304176:C>T,NM_006005.3:c.2654C>T,NP_005996.2:p.Pro885Leu,8/8,\N,Pathogenic,Wolfram syndrome,missense_variant,28.6,0.000116279,EVS_EA_AF,WFS1
616471,4:6304180:C>T,NM_006005.3:c.2658C>T,NP_005996.2:p.Phe886=,8/8,\N,Unknown significance,\N,synonymous_variant,10.87,0.001,1KG_EUR_AF,WFS1
616472,4:6304185:C>T,NM_006005.3:c.2663C>T,NP_005996.2:p.Ser888Leu,8/8,\N,Unknown significance,\N,missense_variant,28.6,0.000234742,EXAC_EAS_AF,WFS1
616473,4:6304185:C>A,NM_006005.3:c.2663C>A,NP_005996.2:p.Ser888Ter,8/8,\N,Pathogenic,Wolfram syndrome,stop_gained,40,\N,\N,WFS1
616474,4:6304186:G>A,NM_006005.3:c.2664G>A,NP_005996.2:p.Ser888=,8/8,\N,Unknown significance,\N,synonymous_variant,6.27,0.0000469425,EXAC_NFE_AF,WFS1
616475,4:6304186:G>C,NM_006005.3:c.2664G>C,NP_005996.2:p.Ser888=,8/8,\N,Unknown significance,\N,synonymous_variant,1.086,0.000117426,EXAC_EAS_AF,WFS1
616476,4:6304186:G>T,NM_006005.3:c.2664G>T,NP_005996.2:p.Ser888=,8/8,\N,Unknown significance,\N,synonymous_variant,1.368,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616477,4:6304188:C>T,NM_006005.3:c.2666C>T,NP_005996.2:p.Ala889Val,8/8,\N,Likely benign,\N,missense_variant,23.5,0.000227273,EVS_AA_AF,WFS1
616478,4:6304189:G>A,NM_006005.3:c.2667G>A,NP_005996.2:p.Ala889=,8/8,\N,Benign,\N,synonymous_variant,0.427,0.005,OTO_TR_AF,WFS1
616479,4:6304191:C>T,NM_006005.3:c.2669C>T,NP_005996.2:p.Ala890Val,8/8,\N,Likely benign,\N,missense_variant,9.881,0.0000156681,EXAC_NFE_AF,WFS1
616480,4:6304195:A>C,NM_006005.3:c.2673A>C,NP_005996.2:p.Ter891CysextTer14,8/8,\N,Unknown significance,\N,stop_lost,5.824,0.0000157401,EXAC_NFE_AF,WFS1
616481,4:6304196:G>C,NM_006005.3:c.*1G>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.031,0.0000157351,EXAC_NFE_AF,WFS1
616482,4:6304196:G>T,NM_006005.3:c.*1G>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.063,0.0000314703,EXAC_NFE_AF,WFS1
616483,4:6304199:T>G,NM_006005.3:c.*4T>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.324,0.0000611247,EXAC_SAS_AF,WFS1
616484,4:6304201:GT>G,NM_006005.3:c.*7del,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.382,\N,\N,WFS1
616485,4:6304203:C>T,NM_006005.3:c.*8C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,7.387,0.0000611995,EXAC_SAS_AF,WFS1
616486,4:6304204:C>G,NM_006005.3:c.*9C>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,2.205,\N,\N,WFS1
616487,4:6304204:C>T,NM_006005.3:c.*9C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.975,0.0014,1KG_AMR_AF,WFS1
616488,4:6304205:G>A,NM_006005.3:c.*10G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.174,0.0000316196,EXAC_NFE_AF,WFS1
616489,4:6304209:C>T,NM_006005.3:c.*14C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.432,0.000117592,EXAC_EAS_AF,WFS1
616490,4:6304210:G>A,NM_006005.3:c.*15G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.038,0.00017507,EXAC_AMR_AF,WFS1
616491,4:6304211:A>C,NM_006005.3:c.*16A>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,2.716,0.0000157759,EXAC_NFE_AF,WFS1
616492,4:6304211:A>G,NM_006005.3:c.*16A>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.145,0.0000875657,EXAC_AMR_AF,WFS1
616493,4:6304213:G>A,NM_006005.3:c.*18G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.523,0.000156152,EXAC_FIN_AF,WFS1
616494,4:6304214:A>C,NM_006005.3:c.*19A>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.182,0.0000612745,EXAC_SAS_AF,WFS1
616495,4:6304222:G>A,NM_006005.3:c.*27G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.379,0.000228102,EVS_AA_AF,WFS1
616496,4:6304222:G>C,NM_006005.3:c.*27G>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.969,0.000104515,EXAC_AFR_AF,WFS1
616497,4:6304223:T>G,NM_006005.3:c.*28T>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.905,0.000104362,EXAC_AFR_AF,WFS1
616498,4:6304225:C>T,NM_006005.3:c.*30C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.321,0.0000315338,EXAC_NFE_AF,WFS1
616499,4:6304226:A>C,NM_006005.3:c.*31A>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.324,0.0000157604,EXAC_NFE_AF,WFS1
616500,4:6304227:T>G,NM_006005.3:c.*32T>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.788,0.0000157599,EXAC_NFE_AF,WFS1
616501,4:6304229:T>G,NM_006005.3:c.*34T>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.165,0.0000157614,EXAC_NFE_AF,WFS1
616502,4:6304236:G>A,NM_006005.3:c.*41G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.864,0.000439059,EXAC_AMR_AF,WFS1
616503,4:6304242:T>C,NM_006005.3:c.*47T>C,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,5.044,0.945854,EXAC_EAS_AF,WFS1
616504,4:6304243:T>G,NM_006005.3:c.*48T>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.318,0.0015,1KG_AFR_AF,WFS1
616505,4:6304246:C>T,NM_006005.3:c.*51C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.89,0.0000315696,EXAC_NFE_AF,WFS1
616506,4:6304249:A>G,NM_006005.3:c.*54A>G,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,6.579,0.0703,1KG_AFR_AF,WFS1
616507,4:6304250:G>A,NM_006005.3:c.*55G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.134,0.0015,1KG_AFR_AF,WFS1
616508,4:6304258:C>T,NM_006005.3:c.*63C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,8.244,\N,\N,WFS1
616509,4:6304264:C>T,NM_006005.3:c.*69C>T,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,5.894,0.0159,1KG_AFR_AF,WFS1
616510,4:6304265:G>A,NM_006005.3:c.*70G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.702,0.001,1KG_EUR_AF,WFS1
616511,4:6304265:G>T,NM_006005.3:c.*70G>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.047,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616512,4:6304273:T>C,NM_006005.3:c.*78T>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.905,0.0014,1KG_AMR_AF,WFS1
616513,4:6304275:C>T,NM_006005.3:c.*80C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.694,0.0023,1KG_AFR_AF,WFS1
616514,4:6304278:C>T,NM_006005.3:c.*83C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.089,0.0014,1KG_AMR_AF,WFS1
616515,4:6304284:C>T,NM_006005.3:c.*89C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.027,0.0008,1KG_AFR_AF,WFS1
616516,4:6304285:G>A,NM_006005.3:c.*90G>A,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,3.226,0.14,OTO_TR_AF,WFS1
616517,4:6304285:GC>AT,NM_006005.3:c.*90_*91delinsAT,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,\N,\N,\N,WFS1
616518,4:6304286:C>T,NM_006005.3:c.*91C>T,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,6.627,0.995,1KG_EAS_AF,WFS1
616519,4:6304288:TGTGCCCACGTGTGCAGA>T,NM_006005.3:c.*94_*110del,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,8.426,0.0038,1KG_AFR_AF,WFS1
616520,4:6304291:GC>G,NM_006005.3:c.*99del,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,3.308,0.0166,1KG_AFR_AF,WFS1
616521,4:6304293:CCA>C,NM_006005.3:c.*100_*101del,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,\N,\N,\N,WFS1
616522,4:6304294:C>A,NM_006005.3:c.*99C>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.803,0.0025,OTO_JP_AF,WFS1
616523,4:6304297:G>A,NM_006005.3:c.*102G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,9.103,\N,\N,WFS1
616524,4:6304309:T>C,NM_006005.3:c.*114T>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.488,\N,\N,WFS1
616525,4:6304318:A>C,NM_006005.3:c.*123A>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.966,0.0014,1KG_AMR_AF,WFS1
616526,4:6304326:C>G,NM_006005.3:c.*131C>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.449,\N,\N,WFS1
616527,4:6304326:C>T,NM_006005.3:c.*131C>T,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,2.635,0.03125,OTO_US_AF,WFS1
616528,4:6304327:G>A,NM_006005.3:c.*132G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.723,0.0025,OTO_JP_AF,WFS1
616529,4:6304328:AC>A,NM_006005.3:c.*135del,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,\N,\N,\N,WFS1
616530,4:6304332:T>C,NM_006005.3:c.*137T>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.59,\N,\N,WFS1
616531,4:6304342:G>A,NM_006005.3:c.*147G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.703,\N,\N,WFS1
616532,4:6304343:C>G,NM_006005.3:c.*148C>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.684,\N,\N,WFS1
616533,4:6304343:C>T,NM_006005.3:c.*148C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,7.213,0.001,1KG_EUR_AF,WFS1
616534,4:6304344:G>A,NM_006005.3:c.*149G>A,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,3.362,0.8661,1KG_EAS_AF,WFS1
616535,4:6304352:C>A,NM_006005.3:c.*157C>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.417,0.0008,1KG_AFR_AF,WFS1
616536,4:6304353:G>A,NM_006005.3:c.*158G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,2.104,0.0014,1KG_AMR_AF,WFS1
616537,4:6304413:G>A,NM_006005.3:c.*218G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,11.44,\N,\N,WFS1
616538,4:6304420:A>G,NM_006005.3:c.*225A>G,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,6.17,0.005,OTO_TR_AF,WFS1
616539,4:6304436:T>C,NM_006005.3:c.*241T>C,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,2.998,0.1785,1KG_AFR_AF,WFS1
616540,4:6304437:G>C,NM_006005.3:c.*242G>C,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,2.123,0.0189,1KG_AFR_AF,WFS1
616541,4:6304448:G>A,NM_006005.3:c.*253G>A,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,6.133,0.21,OTO_TR_AF,WFS1
616542,4:6304455:G>C,NM_006005.3:c.*260G>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.197,\N,\N,WFS1
616543,4:6304458:T>G,NM_006005.3:c.*263T>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,7.853,0.0043,1KG_AMR_AF,WFS1
616544,4:6304469:A>G,NM_006005.3:c.*274A>G,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,7.053,0.190625,OTO_CO_AF,WFS1
616545,4:6304474:A>G,NM_006005.3:c.*279A>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.04,0.001,1KG_SAS_AF,WFS1
616546,4:6304483:C>T,NM_006005.3:c.*288C>T,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,5.144,0.009375,OTO_US_AF,WFS1
616547,4:6304484:G>A,NM_006005.3:c.*289G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.51,0.0025,OTO_JP_AF,WFS1
616548,4:6304485:G>C,NM_006005.3:c.*290G>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.946,0.0008,1KG_AFR_AF,WFS1
616549,4:6304492:G>T,NM_006005.3:c.*297G>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.569,0.001,1KG_EAS_AF,WFS1
616550,4:6304495:A>G,NM_006005.3:c.*300A>G,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,11.1,0.005,OTO_AJ_AF,WFS1
616551,4:6304498:C>T,NM_006005.3:c.*303C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,12.53,\N,\N,WFS1
616552,4:6304512:G>C,NM_006005.3:c.*317G>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.888,0.0025,OTO_JP_AF,WFS1
616553,4:6304521:T>G,NM_006005.3:c.*326T>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,7.107,0.0025,OTO_JP_AF,WFS1
616554,4:6304527:C>G,NM_006005.3:c.*332C>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.573,0.001,1KG_EAS_AF,WFS1
616555,4:6304528:C>A,NM_006005.3:c.*333C>A,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,8.015,0.0635,1KG_AFR_AF,WFS1
616556,4:6304550:C>CTT,NM_006005.3:c.*356_*357insTT,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.678,0.0023,1KG_AFR_AF,WFS1
616557,4:6304550:CTCTT>C,NM_006005.3:c.*365_*368del,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.29,\N,\N,WFS1
616558,4:6304553:T>C,NM_006005.3:c.*358T>C,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,0.314,0.0182,1KG_AFR_AF,WFS1
616559,4:6304554:TTC>T,NM_006005.3:c.*361_*362del,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.563,\N,\N,WFS1
616560,4:6304557:TTTC>T,NM_006005.3:c.*365_*367del,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.085,\N,\N,WFS1
616561,4:6304560:CTTTT>C,NM_006005.3:c.*366_*369del,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.319,\N,\N,WFS1
616562,4:6304567:G>A,NM_006005.3:c.*372G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.12,0.0008,1KG_AFR_AF,WFS1
616563,4:6304589:A>C,NM_006005.3:c.*394A>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.13,0.001,1KG_EAS_AF,WFS1
616564,4:6304614:T>C,NM_006005.3:c.*419T>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.829,\N,\N,WFS1
616565,4:6304622:C>A,NM_006005.3:c.*427C>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,7.508,0.001,1KG_EAS_AF,WFS1
616566,4:6304623:T>G,NM_006005.3:c.*428T>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.74,0.001,1KG_SAS_AF,WFS1
616567,4:6304643:A>T,NM_006005.3:c.*448A>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.248,0.0041,1KG_SAS_AF,WFS1
616568,4:6304646:C>T,NM_006005.3:c.*451C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.33,\N,\N,WFS1
616569,4:6304648:T>G,NM_006005.3:c.*453T>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.105,0.0025,OTO_JP_AF,WFS1
616570,4:6304650:A>G,NM_006005.3:c.*455A>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.395,\N,\N,WFS1
616571,4:6304663:C>T,NM_006005.3:c.*468C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.606,0.001,1KG_EAS_AF,WFS1
616572,4:6304683:G>A,NM_006005.3:c.*488G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.481,0.003,1KG_AFR_AF,WFS1
616573,4:6304691:G>C,NM_006005.3:c.*496G>C,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,1.416,0.0204,1KG_AFR_AF,WFS1
616574,4:6304707:C>T,NM_006005.3:c.*512C>T,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,5.7,0.0605,1KG_AFR_AF,WFS1
616575,4:6304710:G>A,NM_006005.3:c.*515G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.755,0.0008,1KG_AFR_AF,WFS1
616576,4:6304715:G>A,NM_006005.3:c.*520G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.186,0.003125,OTO_CO_AF,WFS1
616577,4:6304718:C>G,NM_006005.3:c.*523C>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.881,0.0008,1KG_AFR_AF,WFS1
616578,4:6304736:A>G,NM_006005.3:c.*541A>G,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,5.512,0.02,OTO_TR_AF,WFS1
616579,4:6304737:G>A,NM_006005.3:c.*542G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,4.703,0.0008,1KG_AFR_AF,WFS1
616580,4:6304762:C>G,NM_006005.3:c.*567C>G,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,3.649,0.0375,OTO_CO_AF,WFS1
616581,4:6304774:C>T,NM_006005.3:c.*579C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.868,0.0008,1KG_AFR_AF,WFS1
616582,4:6304799:G>C,NM_006005.3:c.*604G>C,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,1.842,0.9028,1KG_EAS_AF,WFS1
616583,4:6304816:T>C,NM_006005.3:c.*621T>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,0.917,\N,\N,WFS1
616584,4:6304816:T>G,NM_006005.3:c.*621T>G,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,2.21,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616585,4:6304832:T>C,NM_006005.3:c.*637T>C,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,1.591,0.0598,1KG_AFR_AF,WFS1
616586,4:6304851:C>T,NM_006005.3:c.*656C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.966,\N,\N,WFS1
616587,4:6304856:G>A,NM_006005.3:c.*661G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,5.512,0.002,1KG_SAS_AF,WFS1
616588,4:6304866:A>C,NM_006005.3:c.*671A>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.446,0,OTO_ALL_AF|OTO_AJ_AF|OTO_CO_AF|OTO_US_AF|OTO_JP_AF|OTO_ES_AF|OTO_TR_AF,WFS1
616589,4:6304869:C>T,NM_006005.3:c.*674C>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.48,\N,\N,WFS1
616590,4:6304871:G>T,NM_006005.3:c.*676G>T,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,2.03,0.005,OTO_TR_AF,WFS1
616591,4:6304875:G>GGGT,NM_006005.3:c.*682_*683insTGG,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,2.048,0.0431,1KG_AFR_AF,WFS1
616592,4:6304878:C>A,NM_006005.3:c.*683C>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.189,\N,\N,WFS1
616593,4:6304878:C>CTGTGGGGGA,NM_006005.3:c.*683_*684insTGTGGGGGA,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,2.691,0.0431,1KG_AFR_AF,WFS1
616594,4:6304878:C>T,NM_006005.3:c.*683C>T,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,1.277,0.9038,1KG_EAS_AF,WFS1
616595,4:6304879:G>A,NM_006005.3:c.*684G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.38,0.003125,OTO_US_AF,WFS1
616596,4:6304885:G>C,NM_006005.3:c.*690G>C,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.058,\N,\N,WFS1
616597,4:6304885:G>A,NM_006005.3:c.*690G>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.542,0.0025,OTO_JP_AF,WFS1
616598,4:6304888:G>A,NM_006005.3:c.*693G>A,\N,8/8,\N,Benign,\N,3_prime_UTR_variant,3.472,0.0092,1KG_SAS_AF,WFS1
616599,4:6304888:G>T,NM_006005.3:c.*693G>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.839,\N,\N,WFS1
616600,4:6304895:C>A,NM_006005.3:c.*700C>A,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,6.386,0.001,1KG_EUR_AF,WFS1
616601,4:6304904:G>T,NM_006005.3:c.*709G>T,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,1.922,0.0015,1KG_AFR_AF,WFS1
616602,4:6304915:CCTGA>C,NM_006005.3:c.*724_*727del,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,3.918,\N,\N,WFS1
616603,4:6304949:A>AG,NM_006005.3:c.*757dup,\N,8/8,\N,Unknown significance,\N,3_prime_UTR_variant,\N,\N,\N,WFS